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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of BTN2A1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
BTN2A1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: BTN2A1 (butyrophilin subfamily 2 member A1)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6. A pseudogene of this gene has been identified in this cluster. The encoded protein is an integral plasma membrane protein involved in lipid, fatty-acid, and sterol metabolism. Alterations in this gene may be associated with several disease states including metabolic syndrome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: T cell receptor signaling pathway, lipid metabolic process, regulation of cytokine production; MF: protein binding, signaling receptor binding; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q7KYR7
Entrez ID: 11120
|
Does Knockout of EIF5A in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
EIF5A
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: EIF5A (eukaryotic translation initiation factor 5A)
Type: protein-coding
Summary: Enables U6 snRNA binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to virus, positive regulation of apoptotic process, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of transcription by RNA polymerase II, positive regulation of translational elongation, positive regulation of translational termination, translation, translational elongation, tumor necrosis factor-mediated signaling pathway; MF: RNA binding, U6 snRNA binding, protein binding, ribosome binding, translation elongation factor activity; CC: annulate lamellae, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear pore, nucleus, synapse
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification, Translation Factors, eIF5A regulation in response to inhibition of the nuclear export system
UniProt: P63241
Entrez ID: 1984
|
Does Knockout of RPAP1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
RPAP1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPAP1 (RNA polymerase II associated protein 1)
Type: protein-coding
Summary: This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012].
Gene Ontology: MF: DNA binding, nucleotidyltransferase activity, protein binding, transferase activity; CC: DNA-directed RNA polymerase complex, nucleus
Pathways:
UniProt: Q9BWH6
Entrez ID: 26015
|
Does Knockout of CYP27B1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
CYP27B1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CYP27B1 (cytochrome P450 family 27 subfamily B member 1)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G1 to G0 transition, alcohol metabolic process, bone mineralization, calcitriol biosynthetic process from calciol, calcium ion homeostasis, calcium ion transport, cellular response to vitamin D, decidualization, lipid biosynthetic process, lipid metabolic process, negative regulation of cell growth, negative regulation of cell population proliferation, positive regulation of keratinocyte differentiation, positive regulation of vitamin D receptor signaling pathway, regulation of bone mineralization, response to estrogen, response to lipopolysaccharide, response to type II interferon, response to vitamin D, small molecule biosynthetic process, vitamin D biosynthetic process, vitamin D catabolic process, vitamin D metabolic process, vitamin metabolic process; MF: calcidiol 1-monooxygenase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, secalciferol 1-monooxygenase activity; CC: cytoplasm, membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion
Pathways: 1,25-dihydroxyvitamin D<sub>3</sub> biosynthesis, Biological oxidations, Cytochrome P450 - arranged by substrate type, Defective CYP27B1 causes VDDR1A, Disease, Diseases of metabolism, FGF23 signaling in hypophosphatemic rickets and related disorders, Metabolic disorders of biological oxidation enzymes, Metabolism, Metabolism of lipids, Metabolism of steroids, Metapathway biotransformation Phase I and II, Non-genomic actions of 1,25 dihydroxyvitamin D3, Nuclear Receptors in Lipid Metabolism and Toxicity, Oxidation by Cytochrome P450, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Phase I - Functionalization of compounds, Steroid biosynthesis - Homo sapiens (human), Tuberculosis - Homo sapiens (human), Vitamin D (calciferol) metabolism, Vitamin D Metabolism, Vitamin D Receptor Pathway, Vitamin D-sensitive calcium signaling in depression, Vitamins
UniProt: O15528
Entrez ID: 1594
|
Does Knockout of SYNPO2L in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
SYNPO2L
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: SYNPO2L (synaptopodin 2 like)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Predicted to be involved in several processes, including positive regulation of Rho protein signal transduction; positive regulation of stress fiber assembly; and sarcomere organization. Located in cell junction; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: heart morphogenesis, positive regulation of Rho protein signal transduction, positive regulation of actin filament bundle assembly, positive regulation of stress fiber assembly, sarcomere organization; MF: actin binding, protein binding; CC: Z disc, actin cytoskeleton, cytoplasm, cytoskeleton, nucleus, organelle
Pathways:
UniProt: Q9H987
Entrez ID: 79933
|
Does Knockout of BUB1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
BUB1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: BUB1 (BUB1 mitotic checkpoint serine/threonine kinase)
Type: protein-coding
Summary: This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: apoptotic process, cell division, chromatin remodeling, chromosome segregation, intracellular signal transduction, meiotic sister chromatid cohesion, centromeric, mitotic spindle assembly checkpoint signaling, positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric, regulation of chromosome segregation, regulation of sister chromatid cohesion; MF: ATP binding, histone H2A kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, membrane, nucleoplasm, nucleus, outer kinetochore
Pathways: ATM Signaling Network in Development and Disease, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Aurora B signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), PLK1 signaling events, Progesterone-mediated oocyte maturation - Homo sapiens (human), RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of sister chromatid separation at the metaphase-anaphase transition, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p73 transcription factor network
UniProt: O43683
Entrez ID: 699
|
Does Knockout of RYR1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
RYR1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: RYR1 (ryanodine receptor 1)
Type: protein-coding
Summary: This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, cellular response to caffeine, cellular response to calcium ion, intracellular calcium ion homeostasis, monoatomic ion transmembrane transport, monoatomic ion transport, muscle contraction, ossification involved in bone maturation, outflow tract morphogenesis, protein homotetramerization, regulation of cytosolic calcium ion concentration, release of sequestered calcium ion into cytosol, release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, response to caffeine, response to hypoxia, skeletal muscle fiber development, skin development, striated muscle contraction, transmembrane transport; MF: ATP binding, calcium channel activity, calcium ion binding, calcium-induced calcium release activity, calmodulin binding, intracellularly gated calcium channel activity, metal ion binding, monoatomic ion channel activity, nucleotide binding, ryanodine-sensitive calcium-release channel activity, voltage-gated calcium channel activity; CC: I band, Z disc, calcium channel complex, cell cortex, cytoplasm, extracellular exosome, junctional sarcoplasmic reticulum membrane, membrane, organelle membrane, plasma membrane, ryanodine receptor complex, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum membrane, smooth endoplasmic reticulum, terminal cisterna
Pathways: Airway smooth muscle cell contraction, Apelin signaling pathway - Homo sapiens (human), Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Cardiac conduction, Cell-type Dependent Selectivity of CCK2R Signaling, Circadian entrainment - Homo sapiens (human), Ion channel transport, Ion homeostasis, Long-term depression - Homo sapiens (human), Muscle contraction, Myometrial relaxation and contraction pathways, Oxytocin signaling pathway - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Spinocerebellar ataxia - Homo sapiens (human), Stimuli-sensing channels, Transport of small molecules
UniProt: P21817
Entrez ID: 6261
|
Does Knockout of PKDREJ in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
PKDREJ
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: PKDREJ (polycystin family receptor for egg jelly)
Type: protein-coding
Summary: This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: acrosome reaction, calcium ion transmembrane transport, detection of mechanical stimulus, regulation of acrosome reaction; MF: calcium channel activity, calcium ion binding; CC: acrosomal membrane, cytoplasmic vesicle, membrane, nucleus, plasma membrane, sperm plasma membrane
Pathways:
UniProt: Q9NTG1
Entrez ID: 10343
|
Does Knockout of RAD21 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
RAD21
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RAD21 (RAD21 cohesin complex component)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, apoptotic process, cell division, chromatin looping, chromosome segregation, double-strand break repair, establishment of meiotic sister chromatid cohesion, establishment of mitotic sister chromatid cohesion, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of gene expression, negative regulation of glial cell apoptotic process, negative regulation of interleukin-1 beta production, negative regulation of mitotic metaphase/anaphase transition, negative regulation of neuron apoptotic process, negative regulation of tumor necrosis factor production, positive regulation of gene expression, positive regulation of interleukin-10 production, positive regulation of sister chromatid cohesion, protein localization to chromatin, reciprocal meiotic recombination, regulation of transcription by RNA polymerase II, replication-born double-strand break repair via sister chromatid exchange, response to hypoxia, sister chromatid cohesion; MF: DNA binding, DNA-binding transcription factor binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, lncRNA binding, protein binding; CC: chromatin, chromosome, chromosome, centromeric region, cohesin complex, condensed nuclear chromosome, cytoplasm, cytoskeleton, cytosol, meiotic cohesin complex, membrane, midbody, mitotic cohesin complex, nuclear matrix, nucleoplasm, nucleus, spindle pole
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cohesin Loading onto Chromatin, ESR-mediated signaling, Establishment of Sister Chromatid Cohesion, Estrogen-dependent gene expression, M Phase, Meiosis, Meiotic synapsis, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Telophase/Cytokinesis, Post-translational protein modification, Prion disease pathway, Regulation of sister chromatid separation at the metaphase-anaphase transition, Reproduction, Resolution of Sister Chromatid Cohesion, S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Nuclear Receptors
UniProt: O60216
Entrez ID: 5885
|
Does Inhibition of NDUFB2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
NDUFB2
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NDUFB2 (NADH:ubiquinone oxidoreductase subunit B2)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human)
UniProt: O95178
Entrez ID: 4708
|
Does Activation of BET1 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
BET1
|
protein/peptide accumulation
|
T cell
|
Gene: BET1 (Bet1 golgi vesicular membrane trafficking protein)
Type: protein-coding
Summary: This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, protein binding; CC: Golgi apparatus, Golgi membrane, SNARE complex, cis-Golgi network, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O15155
Entrez ID: 10282
|
Does Knockout of BRWD3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
BRWD3
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: BRWD3 (bromodomain and WD repeat domain containing 3)
Type: protein-coding
Summary: The protein encoded by this gene contains a bromodomain and several WD repeats. It is thought to have a chromatin-modifying function, and may thus play a role in transcription. Mutations in this gene are associated with a spectrum of cognitive disabilities and X-linked macrocephaly. This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: cytoskeleton organization, regulation of cell shape, regulation of transcription by RNA polymerase II
Pathways:
UniProt: Q6RI45
Entrez ID: 254065
|
Does Knockout of UBE2Q2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
UBE2Q2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: UBE2Q2 (ubiquitin conjugating enzyme E2 Q2)
Type: protein-coding
Summary: Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein K48-linked ubiquitination, protein ubiquitination; MF: ATP binding, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q8WVN8
Entrez ID: 92912
|
Does Knockout of METTL2A in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
METTL2A
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: METTL2A (methyltransferase 2A, tRNA N3-cytidine)
Type: protein-coding
Summary: Enables tRNA (cytosine-3-)-methyltransferase activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: methylation, tRNA metabolic process, tRNA methylation, tRNA modification, tRNA processing; MF: RNA methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, protein binding, tRNA (cytidine-3-)-methyltransferase activity, transferase activity; CC: cytoplasm
Pathways:
UniProt: Q96IZ6
Entrez ID: 339175
|
Does Knockout of GPX2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
GPX2
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: GPX2 (glutathione peroxidase 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: cellular oxidant detoxification, response to oxidative stress; MF: electron transfer activity, glutathione peroxidase activity, oxidoreductase activity, peroxidase activity, phospholipid-hydroperoxide glutathione peroxidase activity; CC: cytoplasm, cytosol, intercellular bridge, mitotic spindle
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Arachidonate metabolism, Arachidonic acid metabolism - Homo sapiens (human), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Fatty acid metabolism, Folate Metabolism, Gene expression (Transcription), Generic Transcription Pathway, Glutathione metabolism, Glutathione metabolism - Homo sapiens (human), Huntington disease - Homo sapiens (human), Metabolism, Metabolism of lipids, Metapathway biotransformation Phase I and II, NRF2 pathway, Nuclear Receptors Meta-Pathway, One-carbon metabolism and related pathways, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), RNA Polymerase II Transcription, Selenium Micronutrient Network, Synthesis of 12-eicosatetraenoic acid derivatives, Synthesis of 15-eicosatetraenoic acid derivatives, Synthesis of 5-eicosatetraenoic acids, TP53 Regulates Metabolic Genes, Thyroid hormone synthesis - Homo sapiens (human), Transcriptional Regulation by TP53, Validated transcriptional targets of TAp63 isoforms, Validated transcriptional targets of deltaNp63 isoforms, glutathione redox reactions I, superoxide radicals degradation
UniProt: P18283
Entrez ID: 2877
|
Does Knockout of POP4 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
POP4
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: POP4 (POP4 ribonuclease P/MRP subunit)
Type: protein-coding
Summary: This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: RNA processing, rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: RNA binding, protein binding, ribonuclease P RNA binding, ribonuclease P activity; CC: multimeric ribonuclease P complex, nucleolus, nucleoplasm, nucleus, ribonuclease MRP complex, ribonuclease P complex
Pathways: Metabolism of RNA, RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), tRNA processing, tRNA processing in the nucleus
UniProt: O95707
Entrez ID: 10775
|
Does Knockout of ZAP70 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
ZAP70
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: ZAP70 (zeta chain of T cell receptor associated protein kinase 70)
Type: protein-coding
Summary: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell activation, T cell activation, T cell aggregation, T cell differentiation, T cell migration, T cell receptor signaling pathway, adaptive immune response, alpha-beta T cell differentiation, beta selection, calcium-mediated signaling, immune response, immune system process, intracellular signal transduction, leukocyte cell-cell adhesion, leukocyte migration, negative thymic T cell selection, peptidyl-tyrosine phosphorylation, positive regulation of MAPK cascade, positive regulation of T cell differentiation, positive regulation of alpha-beta T cell differentiation, positive regulation of alpha-beta T cell proliferation, positive regulation of calcium-mediated signaling, positive thymic T cell selection, protein phosphorylation, thymic T cell selection; MF: ATP binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, phosphotyrosine residue binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity; CC: T cell receptor complex, cell-cell junction, cytoplasm, cytosol, immunological synapse, membrane, membrane raft, plasma membrane
Pathways: Adaptive Immune System, BCR, Cancer immunotherapy by PD-1 blockade, Class I PI3K signaling events, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Generation of second messenger molecules, Immune System, Inflammatory Response Pathway, Interferon type I signaling pathways, MicroRNA network associated with chronic lymphocytic leukemia, Modulators of TCR signaling and T cell activation, NF-kappa B signaling pathway - Homo sapiens (human), Natural killer cell mediated cytotoxicity - Homo sapiens (human), Nuclear events stimulated by ALK signaling in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), Pathogenesis of SARS-CoV-2 Mediated by nsp9-nsp10 Complex, Primary immunodeficiency - Homo sapiens (human), Prolactin, Prolactin Signaling Pathway, RHO GTPase cycle, RHOH GTPase cycle, Ras signaling, Ras signaling pathway - Homo sapiens (human), Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, T cell receptor signaling pathway - Homo sapiens (human), T-Cell Receptor and Co-stimulatory Signaling, T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, T-cell receptor (TCR) signaling pathway, TCR, TCR signaling, TCR signaling in naïve CD4+ T cells, TCR signaling in naïve CD8+ T cells, Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Translocation of ZAP-70 to Immunological synapse, Yersinia infection - Homo sapiens (human), activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor, lck and fyn tyrosine kinases in initiation of tcr activation, role of mef2d in t-cell apoptosis, t cell receptor signaling pathway
UniProt: P43403
Entrez ID: 7535
|
Does Knockout of C4BPB in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
C4BPB
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: C4BPB (complement component 4 binding protein beta)
Type: protein-coding
Summary: This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: blood coagulation, complement activation, classical pathway, immune system process, innate immune response, negative regulation of complement activation, classical pathway, positive regulation of protein catabolic process, regulation of opsonization, response to symbiotic bacterium; CC: extracellular region, extracellular space, plasma membrane
Pathways: Complement and coagulation cascades - Homo sapiens (human), Complement cascade, FOXA1 transcription factor network, Immune System, Innate Immune System, Pertussis - Homo sapiens (human), Regulation of Complement cascade
UniProt: P20851
Entrez ID: 725
|
Does Knockout of SAE1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
SAE1
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: SAE1 (SUMO1 activating enzyme subunit 1)
Type: protein-coding
Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010].
Gene Ontology: BP: positive regulation of protein sumoylation, positive regulation of protein targeting to mitochondrion, protein sumoylation, protein ubiquitination; MF: ATP-dependent protein binding, SUMO activating enzyme activity, enzyme activator activity, ligase activity, protein binding, protein heterodimerization activity, small protein activating enzyme binding, ubiquitin activating enzyme activity, ubiquitin-like modifier activating enzyme activity; CC: SUMO activating enzyme complex, cytoplasm, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, SUMO is conjugated to E1 (UBA2:SAE1), SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, Ubiquitin mediated proteolysis - Homo sapiens (human), basic mechanisms of sumoylation, er associated degradation (erad) pathway
UniProt: Q9UBE0
Entrez ID: 10055
|
Does Knockout of SAE1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
SAE1
|
cell proliferation
|
Cancer Cell Line
|
Gene: SAE1 (SUMO1 activating enzyme subunit 1)
Type: protein-coding
Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010].
Gene Ontology: BP: positive regulation of protein sumoylation, positive regulation of protein targeting to mitochondrion, protein sumoylation, protein ubiquitination; MF: ATP-dependent protein binding, SUMO activating enzyme activity, enzyme activator activity, ligase activity, protein binding, protein heterodimerization activity, small protein activating enzyme binding, ubiquitin activating enzyme activity, ubiquitin-like modifier activating enzyme activity; CC: SUMO activating enzyme complex, cytoplasm, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, SUMO is conjugated to E1 (UBA2:SAE1), SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, Ubiquitin mediated proteolysis - Homo sapiens (human), basic mechanisms of sumoylation, er associated degradation (erad) pathway
UniProt: Q9UBE0
Entrez ID: 10055
|
Does Knockout of RPL7 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
RPL7
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: RPL7 (ribosomal protein L7)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal large subunit biogenesis, translation; MF: DNA binding, RNA binding, identical protein binding, mRNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, focal adhesion, membrane, nucleolus, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, VEGFA-VEGFR2 Signaling Pathway, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P18124
Entrez ID: 6129
|
Does Knockout of YPEL5 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,631
|
Knockout
|
YPEL5
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: YPEL5 (yippee like 5)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in cell population proliferation. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding; CC: centrosome, cytoplasm, cytoskeleton, extracellular region, ficolin-1-rich granule lumen, midbody, mitotic spindle pole, nucleus, spindle pole, tertiary granule lumen, ubiquitin ligase complex
Pathways: Ciliary landscape, Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P62699
Entrez ID: 51646
|
Does Knockout of GPATCH2L in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
GPATCH2L
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GPATCH2L (G-patch domain containing 2 like)
Type: protein-coding
Summary: Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q9NWQ4
Entrez ID: 55668
|
Does Knockout of CEMIP in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
CEMIP
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: CEMIP (cell migration inducing hyaluronidase 1)
Type: protein-coding
Summary: Enables several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of protein phosphorylation; and positive regulation of transport. Located in clathrin-coated endocytic vesicle; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: hyaluronan biosynthetic process, hyaluronan catabolic process, hyaluronan metabolic process, positive regulation of cell migration, positive regulation of peptidyl-threonine phosphorylation, positive regulation of protein kinase C activity, positive regulation of protein targeting to membrane, positive regulation of release of sequestered calcium ion into cytosol, sensory perception of sound; MF: ER retention sequence binding, carbohydrate binding, clathrin heavy chain binding, hyaluronic acid binding, hyalurononglucosaminidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, protein binding; CC: clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle membrane, cytoplasm, endoplasmic reticulum, extracellular region, fibrillar center, membrane, nuclear membrane, nucleus, plasma membrane
Pathways: Glycosaminoglycan metabolism, Hyaluronan degradation, Hyaluronan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q8WUJ3
Entrez ID: 57214
|
Does Knockout of GPR173 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
GPR173
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: GPR173 (G protein-coupled receptor 173)
Type: protein-coding
Summary: This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to gonadotropin-releasing hormone, negative regulation of neuron migration, signal transduction; MF: G protein-coupled receptor activity, gonadotropin-releasing hormone receptor activity, protein binding; CC: membrane, plasma membrane
Pathways: GPCRs, Class A Rhodopsin-like
UniProt: Q9NS66
Entrez ID: 54328
|
Does Knockout of MRGPRX1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
MRGPRX1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MRGPRX1 (MAS related GPR family member X1)
Type: protein-coding
Summary: Enables transmembrane signaling receptor activity. Involved in cell surface receptor signaling pathway and response to chloroquine. Predicted to be located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, acute-phase response, cell surface receptor signaling pathway, response to chloroquine, signal transduction; MF: G protein-coupled receptor activity, transmembrane signaling receptor activity; CC: cell surface, membrane, plasma membrane
Pathways:
UniProt: Q96LB2
Entrez ID: 259249
|
Does Knockout of KANK4 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
KANK4
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: KANK4 (KN motif and ankyrin repeat domains 4)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of actin filament polymerization. Located in cytosol and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of actin filament polymerization; CC: cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton
Pathways:
UniProt: Q5T7N3
Entrez ID: 163782
|
Does Knockout of MT3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
MT3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MT3 (metallothionein 3)
Type: protein-coding
Summary: This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017].
Gene Ontology: BP: activation of protein kinase B activity, cellular detoxification, cellular response to cadmium ion, cellular response to copper ion, cellular response to hypoxia, cellular response to oxidative stress, cellular response to reactive oxygen species, cellular response to zinc ion, detoxification of cadmium ion, detoxification of copper ion, energy reserve metabolic process, intracellular monoatomic cation homeostasis, intracellular zinc ion homeostasis, leptin-mediated signaling pathway, negative regulation of apoptotic process, negative regulation of axon extension, negative regulation of cell growth, negative regulation of hydrogen peroxide catabolic process, negative regulation of neurogenesis, negative regulation of neuron apoptotic process, negative regulation of neuron projection development, negative regulation of oxidoreductase activity, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of gene expression, positive regulation of oxygen metabolic process, positive regulation of protein phosphorylation, positive regulation of vascular endothelial growth factor receptor signaling pathway, protein stabilization, regulation of response to food, removal of superoxide radicals, response to hypoxia, response to oxidative stress, zinc ion transport; MF: antioxidant activity, cadmium ion binding, copper ion binding, metal ion binding, metal ion sequestering activity, protein binding, protein kinase activator activity, zinc ion binding; CC: astrocyte end-foot, astrocyte projection, axon, cytoplasm, cytosol, dendritic spine, extracellular space, inclusion body, microtubule, mitochondrial outer membrane, nucleus, perinuclear region of cytoplasm, ribosome, synaptic vesicle
Pathways: Cellular responses to stimuli, Copper homeostasis, Metallothioneins bind metals, Response to metal ions, Zinc homeostasis
UniProt: P25713
Entrez ID: 4504
|
Does Knockout of KLHL11 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
KLHL11
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: KLHL11 (kelch like family member 11)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, cytosol
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9NVR0
Entrez ID: 55175
|
Does Knockout of GRB2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
GRB2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GRB2 (growth factor receptor bound protein 2)
Type: protein-coding
Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell receptor signaling pathway, Ras protein signal transduction, Schwann cell development, T cell activation, T cell costimulation, actin cytoskeleton organization, anatomical structure formation involved in morphogenesis, branching involved in labyrinthine layer morphogenesis, cellular response to ionizing radiation, endodermal cell differentiation, epidermal growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, myelination, natural killer cell mediated cytotoxicity, negative regulation of natural killer cell mediated cytotoxicity, positive regulation of actin filament polymerization, positive regulation of reactive oxygen species metabolic process, receptor internalization, regulation of MAPK cascade, signal transduction, signal transduction in response to DNA damage; MF: RNA binding, SH3 domain binding, ephrin receptor binding, epidermal growth factor receptor binding, guanyl-nucleotide exchange factor adaptor activity, identical protein binding, insulin receptor substrate binding, neurotrophin TRKA receptor binding, phosphotyrosine residue binding, protein binding, protein domain specific binding, protein kinase binding, protein phosphatase binding, protein-macromolecule adaptor activity, transmembrane receptor protein tyrosine kinase adaptor activity; CC: COP9 signalosome, Golgi apparatus, Grb2-EGFR complex, cell cortex, cell-cell junction, centrosome, cytoplasm, cytosol, endosome, extracellular exosome, membrane, nucleoplasm, nucleus, plasma membrane, vesicle membrane
Pathways: 16p11.2 distal deletion syndrome, Activated NTRK2 signals through FRS2 and FRS3, Activated NTRK2 signals through PI3K, Activated NTRK2 signals through RAS, Activated NTRK3 signals through RAS, Acute myeloid leukemia - Homo sapiens (human), Adaptive Immune System, Alcoholism - Homo sapiens (human), Alpha 6 Beta 4 signaling pathway, Alpha6Beta4Integrin, Angiopoietin receptor Tie2-mediated signaling, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Axon guidance, B Cell Receptor Signaling Pathway, B cell receptor signaling pathway - Homo sapiens (human), BCR, BCR signaling pathway, BDNF, BDNF-TrkB Signaling, Bacterial Infection Pathways, Brain-derived neurotrophic factor (BDNF) signaling pathway, Breast cancer - Homo sapiens (human), Breast cancer pathway, CD28 dependent Vav1 pathway, Cargo recognition for clathrin-mediated endocytosis, Cell surface interactions at the vascular wall, Cell-Cell communication, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Choline metabolism in cancer - Homo sapiens (human), Chronic myeloid leukemia - Homo sapiens (human), Clathrin-mediated endocytosis, Co-inhibition by BTLA, Co-stimulation by CD28, Colorectal cancer - Homo sapiens (human), Constitutive Signaling by Aberrant PI3K in Cancer, Constitutive Signaling by EGFRvIII, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Constitutive Signaling by Overexpressed ERBB2, Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, DNA damage response (only ATM dependent), Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downstream signal transduction, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, EGF-EGFR signaling pathway, EGFR Transactivation by Gastrin, EGFR Tyrosine Kinase Inhibitor Resistance, EGFR downregulation, EGFR-dependent Endothelin signaling events, EGFR1, EPHA2 forward signaling, EPHB forward signaling, EPO Receptor Signaling, EPO signaling pathway, ESC Pluripotency Pathways, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Envelope proteins and their potential roles in EDMD physiopathology, Epithelial to mesenchymal transition in colorectal cancer, ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), ErbB1 downstream signaling, ErbB2/ErbB3 signaling events, ErbB4 signaling events, Erythropoietin activates RAS, Estrogen signaling pathway - Homo sapiens (human), FCERI mediated Ca+2 mobilization, FCERI mediated MAPK activation, FCGR3A-mediated phagocytosis, FGF signaling pathway, FGFR1 mutant receptor activation, FLT3 Signaling, FLT3 signaling in disease, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), Fc epsilon receptor (FCERI) signaling, Fc-epsilon receptor I signaling in mast cells, Fcgamma receptor (FCGR) dependent phagocytosis, Fibroblast growth factor-1, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), FoxO signaling pathway - Homo sapiens (human), Fragile X Syndrome, G alpha (q) signalling events, GAB1 signalosome, GMCSF-mediated signaling events, GPCR downstream signalling, GRB2 events in EGFR signaling, GRB2 events in ERBB2 signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , Gap junction - Homo sapiens (human), Gastric cancer - Homo sapiens (human), Gastrin, Gastrin signaling pathway, Gastrin-CREB signalling pathway via PKC and MAPK, Ghrelin, Glioblastoma signaling pathways, Glioma - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hemostasis, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Hepatitis C and Hepatocellular Carcinoma, Hepatocellular carcinoma - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IGF1 pathway, IGF1R signaling cascade, IL-2 signaling pathway, IL-3 signaling pathway, IL-4 signaling pathway, IL-5 signaling pathway, IL-6 signaling pathway, IL-9 signaling pathway, IL2, IL2 signaling events mediated by PI3K, IL2 signaling events mediated by STAT5, IL2-mediated signaling events, IL3, IL3-mediated signaling events, IL4, IL4-mediated signaling events, IL5, IL5-mediated signaling events, IL6, IL6-mediated signaling events, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Infectious disease, InlB-mediated entry of Listeria monocytogenes into host cell, Innate Immune System, Insulin Pathway, Insulin Signaling, Insulin Signalling, Insulin receptor signalling cascade, Insulin signaling pathway - Homo sapiens (human), Integrin signaling, Integrin-mediated Cell Adhesion, Interleukin receptor SHC signaling, Interleukin-11 Signaling Pathway, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Internalization of ErbB1, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Homo sapiens (human), Kallmann,s Syndrome, Kit receptor signaling pathway, KitReceptor, Leishmania infection, Leishmania phagocytosis, Leptin, Leptin signaling pathway, Listeria monocytogenes entry into host cells, MAPK Cascade, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, MET activates PI3K/AKT signaling, MET activates PTPN11, MET activates RAP1 and RAC1, MET activates RAS signaling, MET promotes cell motility, MET receptor recycling, Melanoma, Membrane Trafficking, MicroRNAs in cancer - Homo sapiens (human), Modulators of TCR signaling and T cell activation, NCAM signaling for neurite out-growth, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of MET activity, Negative regulation of the PI3K/AKT network, Nephrin/Neph1 signaling in the kidney podocyte, Nervous system development, Neurotrophic factor-mediated Trk receptor signaling, Neurotrophin signaling pathway - Homo sapiens (human), Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Oncostatin M Signaling Pathway, Oncostatin_M, Osteoclast differentiation - Homo sapiens (human), PDGFR-alpha signaling pathway, PDGFR-beta signaling pathway, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K events in ERBB2 signaling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Parasite infection, Parasitic Infection Pathways, Pathways in cancer - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Pilocytic astrocytoma, Plasma membrane estrogen receptor signaling, Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Potential therapeutics for SARS, Prolactin, Prolactin Signaling Pathway, Prolactin signaling pathway - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, RAF/MAP kinase cascade, RET signaling, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, RHOU GTPase cycle, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of KIT signaling, Regulation of Ras family activation, Regulation of T cell activation by CD28 family, Regulation of actin dynamics for phagocytic cup formation, Regulation of signaling by CBL, Relaxin signaling pathway - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), Role of LAT2/NTAL/LAB on calcium mobilization, SARS-CoV Infections, SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, SHC-related events triggered by IGF1R, SHC1 events in EGFR signaling, SHC1 events in ERBB2 signaling, SHC1 events in ERBB4 signaling, SHP2 signaling, SOS-mediated signalling, STAT5 Activation, Signal Transduction, Signal attenuation, Signal regulatory protein family interactions, Signaling by CSF1 (M-CSF) in myeloid cells, Signaling by EGFR, Signaling by EGFR in Cancer, Signaling by EGFRvIII in Cancer, Signaling by ERBB2, Signaling by ERBB2 ECD mutants, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 TMD/JMD mutants, Signaling by ERBB2 in Cancer, Signaling by ERBB4, Signaling by Erythropoietin, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR1, Signaling by FGFR1 in disease, Signaling by FGFR2, Signaling by FGFR2 in disease, Signaling by FGFR3, Signaling by FGFR3 in disease, Signaling by FGFR4, Signaling by FGFR4 in disease, Signaling by FLT3 fusion proteins, Signaling by GPCR, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by KIT in disease, Signaling by Ligand-Responsive EGFR Variants in Cancer, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRK2 (TRKB), Signaling by NTRK3 (TRKC), Signaling by NTRKs, Signaling by PDGF, Signaling by PDGFR in disease, Signaling by PDGFRA extracellular domain mutants, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by cytosolic FGFR1 fusion mutants, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants, Signaling by the B Cell Receptor (BCR), Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by PTP1B, Signaling events mediated by Stem cell factor receptor (c-Kit), Signaling events mediated by TCPTP, Signaling events mediated by VEGFR1 and VEGFR2, Signaling events mediated by focal adhesion kinase, Signaling events regulated by Ret tyrosine kinase, Signaling of Hepatocyte Growth Factor Receptor, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Signalling to ERKs, Signalling to RAS, Spry regulation of FGF signaling, T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, T-cell receptor (TCR) signaling pathway, TCR, TCR signaling in naïve CD4+ T cells, TCR signaling in naïve CD8+ T cells, TGF-beta Signaling Pathway, TGF-beta receptor signaling, TNF-alpha signaling pathway, TNFalpha, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, Tie2 Signaling, Trk receptor signaling mediated by PI3K and PLC-gamma, VEGFA-VEGFR2 Signaling Pathway, VEGFR3 signaling in lymphatic endothelium, Vesicle-mediated transport, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), a6b1 and a6b4 Integrin signaling, angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling, bcr signaling pathway, bioactive peptide induced signaling pathway, calcium signaling by hbx of hepatitis b virus, cbl mediated ligand-induced downregulation of egf receptors pathway, egf signaling pathway, epo signaling pathway, erk1/erk2 mapk signaling pathway, fc epsilon receptor i signaling in mast cells, growth hormone signaling pathway, igf-1 signaling pathway, il 2 signaling pathway, il 3 signaling pathway, il 4 signaling pathway, il 6 signaling pathway, il-2 receptor beta chain in t cell activation, inhibition of cellular proliferation by gleevec, insulin signaling pathway, integrin signaling pathway, keratinocyte differentiation, links between pyk2 and map kinases, mTOR signaling pathway - Homo sapiens (human), map kinase inactivation of smrt corepressor, mcalpain and friends in cell motility, multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation, nerve growth factor pathway (ngf), nfat and hypertrophy of the heart , p38 MAPK Signaling Pathway, pdgf signaling pathway, phospholipids as signalling intermediaries, phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway, pten dependent cell cycle arrest and apoptosis, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, role of erbb2 in signal transduction and oncology, role of erk5 in neuronal survival pathway, sprouty regulation of tyrosine kinase signals, t cell receptor signaling pathway, the co-stimulatory signal during t-cell activation, the igf-1 receptor and longevity, tpo signaling pathway, transcription factor creb and its extracellular signals, trefoil factors initiate mucosal healing, trka receptor signaling pathway, vegf hypoxia and angiogenesis
UniProt: P62993
Entrez ID: 2885
|
Does Knockout of KCNH1 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
KCNH1
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: KCNH1 (potassium voltage-gated channel subfamily H member 1)
Type: protein-coding
Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to calcium ion, monoatomic ion transmembrane transport, monoatomic ion transport, myoblast fusion, potassium ion transmembrane transport, potassium ion transport, regulation of cell population proliferation, regulation of membrane potential, transmembrane transport; MF: calmodulin binding, cyclic nucleotide binding, delayed rectifier potassium channel activity, lipid binding, monoatomic ion channel activity, phosphatidylinositol bisphosphate binding, potassium channel activity, protein binding, voltage-gated potassium channel activity; CC: axon, cell projection, dendrite, early endosome membrane, endosome, membrane, monoatomic ion channel complex, nuclear inner membrane, nucleus, perikaryon, plasma membrane, postsynaptic density membrane, postsynaptic membrane, presynaptic membrane, synapse, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: O95259
Entrez ID: 3756
|
Does Knockout of CACNA1S in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
CACNA1S
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CACNA1S (calcium voltage-gated channel subunit alpha1 S)
Type: protein-coding
Summary: This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, cellular response to caffeine, endoplasmic reticulum organization, extraocular skeletal muscle development, monoatomic ion transmembrane transport, monoatomic ion transport, muscle cell development, muscle contraction, myoblast fusion, neuromuscular junction development, positive regulation of muscle contraction, release of sequestered calcium ion into cytosol, skeletal muscle adaptation, skeletal muscle fiber development, skeletal muscle tissue development, skeletal system development, striated muscle contraction, transmembrane transport; MF: calcium channel activity, calmodulin binding, high voltage-gated calcium channel activity, metal ion binding, molecular function activator activity, monoatomic ion channel activity, protein binding, small molecule binding, voltage-gated calcium channel activity; CC: I band, L-type voltage-gated calcium channel complex, T-tubule, cytoplasm, membrane, monoatomic ion channel complex, plasma membrane, sarcoplasmic reticulum, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Axon guidance, Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Developmental Biology, Dilated cardiomyopathy - Homo sapiens (human), GABAergic synapse - Homo sapiens (human), GnRH secretion - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Insulin secretion - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Oxytocin signaling pathway - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Renin secretion - Homo sapiens (human), Retrograde endocannabinoid signaling - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Vascular smooth muscle contraction - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: Q13698
Entrez ID: 779
|
Does Knockout of KRI1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
KRI1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: KRI1 (KRI1 homolog)
Type: protein-coding
Summary: This gene overlaps with the gene for cysteine endopeptidase AUT-like 4 in a head-to-tail orientation. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: 90S preribosome, nucleolus
Pathways:
UniProt: Q8N9T8
Entrez ID: 65095
|
Does Knockout of UBE2N in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
UBE2N
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: UBE2N (ubiquitin conjugating enzyme E2 N)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA repair, T cell receptor signaling pathway, TORC1 signaling, antiviral innate immune response, cellular response to nutrient levels, double-strand break repair via homologous recombination, negative regulation of TORC1 signaling, positive regulation of DNA repair, positive regulation of NF-kappaB transcription factor activity, positive regulation of canonical NF-kappaB signal transduction, positive regulation of double-strand break repair, positive regulation of intracellular signal transduction, positive regulation of protein K63-linked ubiquitination, postreplication repair, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked ubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of DNA repair, ubiquitin-dependent protein catabolic process; MF: ATP binding, RNA binding, nucleotide binding, protein binding, transferase activity, ubiquitin binding, ubiquitin conjugating enzyme activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activator activity, ubiquitin-protein transferase activity; CC: UBC13-MMS2 complex, cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, protein-containing complex, ubiquitin conjugating enzyme complex, ubiquitin ligase complex
Pathways: 3q29 copy number variation syndrome, ATM pathway, Adaptive Immune System, Aggrephagy, Antigen processing: Ubiquitination & Proteasome degradation, Antiviral mechanism by IFN-stimulated genes, Autophagy, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cell Cycle, Cell Cycle Checkpoints, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Disease, Downstream TCR signaling, E3 ubiquitin ligases ubiquitinate target proteins, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of Incision Complex in GG-NER, G2/M Checkpoints, G2/M DNA damage checkpoint, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, IKK complex recruitment mediated by RIP1, IL-1 signaling pathway, IL1, IL1-mediated signaling events, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, ISG15 antiviral mechanism, Immune System, Infectious disease, Innate Immune System, Interferon Signaling, Interleukin-1 Induced Activation of NF-kappa-B, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, MAP kinase activation, Macroautophagy, Metabolism of proteins, Mitophagy, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NOD1/2 Signaling Pathway, Nonhomologous End-Joining (NHEJ), Nucleotide Excision Repair, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, PINK1-PRKN Mediated Mitophagy, Post-translational protein modification, Processing of DNA double-strand break ends, Protein ubiquitination, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Selective autophagy, Shigellosis - Homo sapiens (human), Signaling by Interleukins, Simplified Depiction of MYD88 Distinct Input-Output Pathway, TAK1-dependent IKK and NF-kappa-B activation , TCR signaling, TICAM1, RIP1-mediated IKK complex recruitment, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ubiquitin mediated proteolysis - Homo sapiens (human), Viral Infection Pathways, activated TAK1 mediates p38 MAPK activation
UniProt: P61088
Entrez ID: 7334
|
Does Knockout of RPS19BP1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
RPS19BP1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: RPS19BP1 (ribosomal protein S19 binding protein 1)
Type: protein-coding
Summary: Enables enzyme binding activity. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, enzyme binding, protein binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: Q86WX3
Entrez ID: 91582
|
Does Knockout of DCK in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
DCK
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: DCK (deoxycytidine kinase)
Type: protein-coding
Summary: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: CMP biosynthetic process, carbohydrate derivative metabolic process, dAMP salvage, nucleobase-containing compound metabolic process, nucleoside phosphate biosynthetic process, pyrimidine nucleotide metabolic process; MF: ATP binding, cytidine kinase activity, deoxyadenosine kinase activity, deoxycytidine kinase activity, deoxyguanosine kinase activity, deoxynucleoside kinase activity, kinase activity, nucleotide binding, protein binding, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Gemcitabine Action Pathway, Gemcitabine Metabolism Pathway, Lamivudine Metabolism Pathway, Metabolism, Metabolism of nucleotides, Nucleotide salvage, Purine metabolism - Homo sapiens (human), Purine salvage, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), Pyrimidine salvage, Retinoblastoma gene in cancer, purine deoxyribonucleosides salvage, pyrimidine deoxyribonucleosides salvage, superpathway of pyrimidine deoxyribonucleoside salvage
UniProt: P27707
Entrez ID: 1633
|
Does Knockout of NSUN4 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
NSUN4
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: NSUN4 (NOP2/Sun RNA methyltransferase 4)
Type: protein-coding
Summary: Enables rRNA (cytosine-C5-)-methyltransferase activity. Involved in rRNA methylation. Part of mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA methylation, RNA processing, methylation, mitochondrial RNA catabolic process, mitochondrial RNA modification, rRNA methylation, rRNA processing, ribosome biogenesis; MF: RNA binding, RNA methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, mRNA (cytidine-5-)-methyltransferase activity, methyltransferase activity, protein binding, rRNA (cytosine-C5-)-methyltransferase activity, rRNA binding, rRNA methyltransferase activity, transferase activity; CC: mitochondrial large ribosomal subunit, mitochondrial matrix, mitochondrion
Pathways: Metabolism of RNA, rRNA modification in the mitochondrion, rRNA processing, rRNA processing in the mitochondrion
UniProt: Q96CB9
Entrez ID: 387338
|
Does Knockout of FEN1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
FEN1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: FEN1 (flap structure-specific endonuclease 1)
Type: protein-coding
Summary: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA replication, DNA replication, removal of RNA primer, UV protection, base-excision repair, base-excision repair, gap-filling, double-strand break repair, double-strand break repair via homologous recombination, memory, positive regulation of sister chromatid cohesion, telomere maintenance via semi-conservative replication; MF: 5'-3' exonuclease activity, 5'-flap endonuclease activity, DNA binding, DNA endonuclease activity, RNA-DNA hybrid ribonuclease activity, catalytic activity, damaged DNA binding, double-stranded DNA binding, double-stranded DNA exodeoxyribonuclease activity, endonuclease activity, exonuclease activity, flap endonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds, magnesium ion binding, manganese ion binding, metal ion binding, nuclease activity, protein binding; CC: chromosome, telomeric region, membrane, mitochondrion, nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways: Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Disease, Early Phase of HIV Life Cycle, Extension of Telomeres, HDR through MMEJ (alt-NHEJ), HIV Infection, HIV Life Cycle, Homology Directed Repair, Infectious disease, Lagging Strand Synthesis, Non-homologous end-joining - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, POLB-Dependent Long Patch Base Excision Repair, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Viral Infection Pathways
UniProt: P39748
Entrez ID: 2237
|
Does Knockout of PIP4K2A in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
PIP4K2A
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha)
Type: protein-coding
Summary: Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process, autophagosome-lysosome fusion, lipid metabolic process, megakaryocyte development, negative regulation of insulin receptor signaling pathway, phosphatidylinositol metabolic process, phosphatidylinositol phosphate biosynthetic process, positive regulation of autophagosome assembly, regulation of autophagy, vesicle-mediated cholesterol transport; MF: 1-phosphatidylinositol-4-phosphate 5-kinase activity, 1-phosphatidylinositol-5-phosphate 4-kinase activity, ATP binding, kinase activity, nucleotide binding, phosphatidylinositol kinase activity, protein binding, protein homodimerization activity, transferase activity; CC: autophagosome, cell projection, cytoplasm, cytosol, lysosome, membrane, nucleoplasm, nucleus, photoreceptor inner segment, photoreceptor outer segment, plasma membrane
Pathways: BCR, D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, D-<i>myo</i>-inositol-5-phosphate metabolism, G13 Signaling Pathway, Gene expression (Transcription), Generic Transcription Pathway, Inositol phosphate metabolism - Homo sapiens (human), Intracellular signaling by second messengers, Joubert syndrome, Metabolism, Metabolism of lipids, Negative regulation of the PI3K/AKT network, PI Metabolism, PI5P Regulates TP53 Acetylation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Phosphatidylinositol Phosphate Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipid metabolism, RNA Polymerase II Transcription, Regulation of Actin Cytoskeleton, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of actin cytoskeleton - Homo sapiens (human), Signal Transduction, Synthesis of PIPs at the plasma membrane, Synthesis of PIPs in the nucleus, Transcriptional Regulation by TP53, superpathway of inositol phosphate compounds
UniProt: P48426
Entrez ID: 5305
|
Does Knockout of SARS2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
SARS2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: SARS2 (seryl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: mitochondrial seryl-tRNA aminoacylation, seryl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, RNA binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, protein binding, serine-tRNA ligase activity, tRNA binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Metabolism of proteins, Mitochondrial tRNA aminoacylation, Translation, selenocysteine biosynthesis, tRNA Aminoacylation, tRNA charging
UniProt: Q9NP81
Entrez ID: 54938
|
Does Knockout of TRIM49C in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
TRIM49C
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: TRIM49C (tripartite motif containing 49C)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: innate immune response, regulation of gene expression; MF: metal ion binding, protein binding, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: P0CI26
Entrez ID: 642612
|
Does Knockout of KPNA7 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
KPNA7
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: KPNA7 (karyopherin subunit alpha 7)
Type: protein-coding
Summary: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import, but exhibits different nuclear localization signal binding specificity compared to other members of the family. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: NLS-bearing protein import into nucleus, blastocyst development, epigenetic regulation of gene expression, negative regulation of gene expression, positive regulation of gene expression, protein import into nucleus, protein transport; MF: nuclear import signal receptor activity, nuclear localization sequence binding, protein binding; CC: NLS-dependent protein nuclear import complex, cytoplasm, cytosol, female germ cell nucleus, nucleoplasm, nucleus, spindle
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Disease, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza A - Homo sapiens (human), Influenza Infection, Interferon Signaling, NS1 Mediated Effects on Host Pathways, Viral Infection Pathways
UniProt: A9QM74
Entrez ID: 402569
|
Does Knockout of LBX1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
LBX1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: LBX1 (ladybird homeobox 1)
Type: protein-coding
Summary: This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, cell population proliferation, glutamatergic neuron differentiation, heart looping, muscle organ development, negative regulation of cell population proliferation, negative regulation of glutamatergic neuron differentiation, nervous system development, neuron fate commitment, neuron fate determination, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spinal cord motor neuron differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus, transcription regulator complex
Pathways:
UniProt: P52954
Entrez ID: 10660
|
Does Knockout of CDC26 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
CDC26
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: CDC26 (cell division cycle 26)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; CC: anaphase-promoting complex, cytosol, nucleoplasm, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q8NHZ8
Entrez ID: 246184
|
Does Knockout of BBS9 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
BBS9
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: BBS9 (Bardet-Biedl syndrome 9)
Type: protein-coding
Summary: This gene is downregulated by parathyroid hormone in osteoblastic cells, and therefore is thought to be involved in parathyroid hormone action in bones. The exact function of this gene has not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: cell projection organization, cilium assembly, fat cell differentiation, protein localization to cilium, protein transport, visual perception; MF: molecular_function, protein binding; CC: BBSome, cell projection, centriolar satellite, centrosome, ciliary basal body, ciliary membrane, ciliary transition zone, cilium, cytoplasm, cytoskeleton, cytosol, membrane, nucleoplasm, pericentriolar material, plasma membrane
Pathways: BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Ciliary landscape, Ciliopathies, Cilium Assembly, Genes related to primary cilium development (based on CRISPR), Joubert Syndrome, Organelle biogenesis and maintenance
UniProt: Q3SYG4
Entrez ID: 27241
|
Does Knockout of OR2A1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
OR2A1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: OR2A1 (olfactory receptor family 2 subfamily A member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGT9
Entrez ID: 346528
|
Does Knockout of WDR3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
WDR3
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: WDR3 (WD repeat domain 3)
Type: protein-coding
Summary: This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: maturation of SSU-rRNA, ribosomal small subunit biogenesis; MF: RNA binding, snoRNA binding; CC: Pwp2p-containing subcomplex of 90S preribosome, nuclear membrane, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9UNX4
Entrez ID: 10885
|
Does Knockout of PICALM in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
PICALM
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PICALM (phosphatidylinositol binding clathrin assembly protein)
Type: protein-coding
Summary: This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
Gene Ontology: BP: amyloid-beta clearance by transcytosis, axonogenesis, clathrin coat assembly, clathrin-dependent endocytosis, dendrite morphogenesis, endocytosis, endosomal transport, hemopoiesis, intracellular iron ion homeostasis, learning or memory, membrane bending, multicellular organismal-level iron ion homeostasis, negative regulation of gene expression, negative regulation of protein localization to cell surface, negative regulation of protein localization to plasma membrane, negative regulation of receptor-mediated endocytosis, positive regulation of DNA-templated transcription, positive regulation of Ras protein signal transduction, positive regulation of amyloid precursor protein catabolic process, positive regulation of amyloid-beta formation, protein-containing complex assembly, receptor internalization, receptor-mediated endocytosis, regulation of amyloid precursor protein catabolic process, regulation of amyloid-beta formation, regulation of endocytosis, regulation of protein localization, regulation of receptor-mediated endocytosis, regulation of vesicle size, synaptic vesicle maturation, vesicle budding from membrane, vesicle cargo loading, vesicle-mediated transport; MF: 1-phosphatidylinositol binding, SNARE binding, amyloid-beta binding, cadherin binding, clathrin binding, clathrin heavy chain binding, low-density lipoprotein particle receptor binding, phosphatidylinositol-4,5-bisphosphate binding, phospholipid binding, protein binding, small GTPase binding, tau protein binding; CC: Golgi apparatus, cell surface, clathrin coat of coated pit, clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle, cytoplasmic vesicle, cytosol, early endosome, endomembrane system, endosome to plasma membrane transport vesicle, extrinsic component of presynaptic endocytic zone membrane, membrane, neurofibrillary tangle, neuronal cell body, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynaptic membrane, presynaptic membrane, synaptic vesicle, vesicle
Pathways: endocytotic role of ndk phosphins and dynamin
UniProt: Q13492
Entrez ID: 8301
|
Does Knockout of OR13F1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
OR13F1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: OR13F1 (olfactory receptor family 13 subfamily F member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGS4
Entrez ID: 138805
|
Does Knockout of SIPA1L2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
SIPA1L2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: SIPA1L2 (signal induced proliferation associated 1 like 2)
Type: protein-coding
Summary: This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: biological_process, presynaptic signal transduction, regulation of small GTPase mediated signal transduction; MF: GTPase activator activity, protein binding; CC: cellular_component, cytoplasm, glutamatergic synapse
Pathways: Rap1 signaling pathway - Homo sapiens (human)
UniProt: Q9P2F8
Entrez ID: 57568
|
Does Knockout of PACS2 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
PACS2
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: PACS2 (phosphofurin acidic cluster sorting protein 2)
Type: protein-coding
Summary: Predicted to enable transmembrane transporter binding activity. Involved in endoplasmic reticulum calcium ion homeostasis; mitochondrion-endoplasmic reticulum membrane tethering; and protein localization to plasma membrane. Acts upstream of or within protein localization to phagophore assembly site. Located in endoplasmic reticulum and mitochondrion. Implicated in developmental and epileptic encephalopathy 66. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, autophagosome assembly, endoplasmic reticulum calcium ion homeostasis, mitochondrion-endoplasmic reticulum membrane tethering, protein localization to phagophore assembly site, protein localization to plasma membrane; MF: protein binding, transmembrane transporter binding; CC: endoplasmic reticulum, mitochondrion
Pathways:
UniProt: Q86VP3
Entrez ID: 23241
|
Does Knockout of REXO4 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
REXO4
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: REXO4 (REX4 homolog, 3'-5' exonuclease)
Type: protein-coding
Summary: Enables DNA binding activity and nuclease activity. Involved in DNA catabolic process, endonucleolytic; DNA catabolic process, exonucleolytic; and DNA repair. Located in nuclear speck and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA catabolic process, DNA metabolic process, DNA repair, RNA processing, rRNA processing, regulation of DNA-templated transcription; MF: 3'-5' exonuclease activity, RNA binding, double-stranded DNA binding, endonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, protein binding, single-stranded DNA binding; CC: nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9GZR2
Entrez ID: 57109
|
Does Knockout of FOXD4L1 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
FOXD4L1
|
response to virus
|
Huh-7 Cell
|
Gene: FOXD4L1 (forkhead box D4 like 1)
Type: protein-coding
Summary: This gene is a member of the forkhead/winged-helix (FOX) family of transcription factors with highly conserved FOX DNA-binding domains. Members of the FOX family of transcription factors are regulators of embryogenesis and may play a role in human cancer. This gene lies in a region of chromosome 2 that surrounds the site where two ancestral chromosomes fused to form human chromosome 2. This region is duplicated elsewhere in the human genome, primarily in subtelomeric and pericentromeric locations, thus mutiple copies of this gene have been found. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: Q9NU39
Entrez ID: 200350
|
Does Knockout of DNLZ in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
DNLZ
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: DNLZ (DNL-type zinc finger)
Type: protein-coding
Summary: Predicted to enable chaperone binding activity. Predicted to be involved in protein folding; protein import into mitochondrial matrix; and protein stabilization. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chaperone-mediated protein complex assembly, protein folding, protein import into mitochondrial matrix, protein stabilization; MF: metal ion binding, protein folding chaperone, protein-folding chaperone binding, zinc ion binding; CC: cytosol, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q5SXM8
Entrez ID: 728489
|
Does Knockout of MMP20 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
MMP20
|
response to virus
|
Hepatoma Cell Line
|
Gene: MMP20 (matrix metallopeptidase 20)
Type: protein-coding
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: amelogenesis, collagen catabolic process, extracellular matrix disassembly, extracellular matrix organization, protein catabolic process, proteolysis, regulation of enamel mineralization; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein binding, zinc ion binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Extracellular matrix organization, Matrix Metalloproteinases
UniProt: O60882
Entrez ID: 9313
|
Does Knockout of SMARCE1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
SMARCE1
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: SMARCE1 (SWI/SNF related BAF chromatin remodeling complex subunit E1)
Type: protein-coding
Summary: The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, nervous system development, neurogenesis, nucleosome disassembly, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: DNA binding, N-acetyltransferase activity, RNA binding, chromatin binding, nuclear receptor binding, nucleosomal DNA binding, protein binding, transcription coactivator activity; CC: RSC-type complex, SWI/SNF complex, bBAF complex, brahma complex, chromatin, kinetochore, nBAF complex, npBAF complex, nuclear chromosome, nuclear matrix, nucleoplasm, nucleus, protein-containing complex
Pathways: Androgen receptor signaling pathway, AndrogenReceptor, Hepatocellular carcinoma - Homo sapiens (human), Pathways affected in adenoid cystic carcinoma, Regulation of Androgen receptor activity, TNFalpha, Thermogenesis, Thermogenesis - Homo sapiens (human), Tumor suppressor activity of SMARCB1, Validated nuclear estrogen receptor beta network, chromatin remodeling by hswi/snf atp-dependent complexes, the information processing pathway at the ifn beta enhancer
UniProt: Q969G3
Entrez ID: 6605
|
Does Knockout of LMAN1L in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
LMAN1L
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: LMAN1L (lectin, mannose binding 1 like)
Type: protein-coding
Summary: This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. [provided by RefSeq, Jan 2017].
Gene Ontology: MF: D-mannose binding, carbohydrate binding; CC: COPII-coated ER to Golgi transport vesicle, Golgi membrane, endomembrane system, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular matrix, membrane
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9HAT1
Entrez ID: 79748
|
Does Knockout of SBNO1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
SBNO1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: SBNO1 (strawberry notch homolog 1)
Type: protein-coding
Summary: Predicted to enable chromatin DNA binding activity and histone binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Wnt signaling pathway, inflammatory response, negative regulation of MAPK cascade, negative regulation of canonical NF-kappaB signal transduction, negative regulation of neuroinflammatory response, positive regulation of canonical Wnt signaling pathway, positive regulation of neural precursor cell proliferation, positive regulation of signal transduction, regulation of DNA-templated transcription; MF: chromatin DNA binding, histone binding; CC: nucleus
Pathways:
UniProt: A3KN83
Entrez ID: 55206
|
Does Knockout of TEX14 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
TEX14
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: TEX14 (testis expressed 14, intercellular bridge forming factor)
Type: protein-coding
Summary: The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011].
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, cellular response to leukemia inhibitory factor, intercellular bridge organization, male meiotic nuclear division, mitotic sister chromatid separation, mitotic spindle assembly checkpoint signaling, negative regulation of cytokinesis; MF: ATP binding, nucleotide binding, protein binding, protein kinase activity, protein kinase binding; CC: chromosome, chromosome, centromeric region, cytoplasm, extracellular exosome, intercellular bridge, kinetochore, midbody
Pathways:
UniProt: Q8IWB6
Entrez ID: 56155
|
Does Knockout of POLA2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
POLA2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: POLA2 (DNA polymerase alpha 2, accessory subunit)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Involved in DNA replication, synthesis of RNA primer. Located in cytosol and nucleoplasm. Part of alpha DNA polymerase:primase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA replication, DNA replication initiation, DNA replication, synthesis of primer, protein import into nucleus; MF: DNA binding, protein binding; CC: alpha DNA polymerase:primase complex, ciliary basal body, cytosol, nucleoplasm, nucleus
Pathways: Activation of the pre-replicative complex, Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA replication initiation, DNA strand elongation, Defective pyroptosis, Disease, Diseases of programmed cell death, E2F mediated regulation of DNA replication, Extension of Telomeres, G1 to S cell cycle control, G1/S Transition, Inhibition of replication initiation of damaged DNA by RB1/E2F1, Lagging Strand Synthesis, Leading Strand Synthesis, Mitotic G1 phase and G1/S transition, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the lagging strand, Pyrimidine metabolism, Removal of the Flap Intermediate, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: Q14181
Entrez ID: 23649
|
Does Knockout of CRYGA in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
CRYGA
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: CRYGA (crystallin gamma A)
Type: protein-coding
Summary: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: eye development, lens development in camera-type eye, visual perception; MF: structural constituent of eye lens
Pathways:
UniProt: P11844
Entrez ID: 1418
|
Does Knockout of FTSJ1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
FTSJ1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1)
Type: protein-coding
Summary: This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: RNA methylation, cytoplasmic translation, methylation, neurogenesis, tRNA methylation, tRNA modification, tRNA nucleoside ribose methylation, tRNA processing, wobble position ribose methylation; MF: S-adenosyl-L-methionine binding, methyltransferase activity, protein binding, tRNA (guanine) methyltransferase activity, tRNA (guanosine(34)-2'-O)-methyltransferase activity, tRNA 2'-O-methyltransferase activity, tRNA methyltransferase activity, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Metabolism of RNA, tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q9UET6
Entrez ID: 24140
|
Does Knockout of WDR5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
WDR5
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: WDR5 (WD repeat domain 5)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin organization, gluconeogenesis, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gluconeogenesis, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II, skeletal system development, transcription initiation-coupled chromatin remodeling; MF: histone H3K4 methyltransferase activity, histone H3K4me1 reader activity, histone H3Q5ser reader activity, histone binding, protein binding; CC: ATAC complex, MLL1 complex, MLL1/2 complex, MLL3/4 complex, NSL complex, Set1C/COMPASS complex, histone acetyltransferase complex, histone methyltransferase complex, mitotic spindle, nucleoplasm, nucleus
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Adaptive Immune System, Cardiogenesis, Chromatin modifying enzymes, Chromatin organization, Circadian rhythm pathway, Co-inhibition by PD-1, Cushing syndrome - Homo sapiens (human), Developmental Biology, Disease, Disorders of Developmental Biology, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, Immune System, Loss of Function of KMT2D in Kabuki Syndrome, Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism of proteins, Neddylation, PKMTs methylate histone lysines, Post-translational protein modification, RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Transcriptional regulation by RUNX1
UniProt: P61964
Entrez ID: 11091
|
Does Knockout of YBX2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
YBX2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: YBX2 (Y-box binding protein 2)
Type: protein-coding
Summary: This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: oocyte development, positive regulation of cold-induced thermogenesis, regulation of gene expression, spermatogenesis, transcription by RNA polymerase II, translational attenuation; MF: DNA binding, RNA binding, nucleic acid binding; CC: cytoplasm, nucleus
Pathways: Male infertility
UniProt: Q9Y2T7
Entrez ID: 51087
|
Does Knockout of NKIRAS1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
NKIRAS1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NKIRAS1 (NFKB inhibitor interacting Ras like 1)
Type: protein-coding
Summary: Predicted to enable GTPase activating protein binding activity. Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within several processes, including Ral protein signal transduction; lung alveolus development; and surfactant homeostasis. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Ral protein signal transduction, lung alveolus development, negative regulation of canonical NF-kappaB signal transduction, regulation of tumor necrosis factor-mediated signaling pathway, surfactant homeostasis; MF: GTP binding, GTPase activating protein binding, GTPase activity, nucleotide binding; CC: cytoplasm, cytosol, endoplasmic reticulum
Pathways: Cytokine Signaling in Immune system, Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, RIP-mediated NFkB activation via ZBP1, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TNFalpha, TRAF6 mediated NF-kB activation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, ZBP1(DAI) mediated induction of type I IFNs
UniProt: Q9NYS0
Entrez ID: 28512
|
Does Activation of CDX4 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
CDX4
|
response to virus
|
Hepatoma Cell Line
|
Gene: CDX4 (caudal type homeobox 4)
Type: protein-coding
Summary: This gene encodes a member of a small subfamily of homeobox containing transcription factors. The encoded protein may regulate homeobox gene expression during anteroposterior patterning and hematopoiesis. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: anterior/posterior axis specification, anterior/posterior pattern specification, blood vessel development, cell differentiation, digestive tract development, embryonic pattern specification, labyrinthine layer development, negative regulation of transcription by RNA polymerase II, placenta development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways: Regulation of nuclear beta catenin signaling and target gene transcription
UniProt: O14627
Entrez ID: 1046
|
Does Knockout of GLRX5 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
GLRX5
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: GLRX5 (glutaredoxin 5)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010].
Gene Ontology: BP: [2Fe-2S] cluster assembly, cell redox homeostasis, hemopoiesis, intracellular iron ion homeostasis, iron-sulfur cluster assembly, protein maturation; MF: 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding, protein binding; CC: dendrite, iron-sulfur cluster assembly complex, mitochondrial matrix, mitochondrion, neuronal cell body
Pathways: Metabolism, Mitochondrial iron-sulfur cluster biogenesis
UniProt: Q86SX6
Entrez ID: 51218
|
Does Knockout of RPL17 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
RPL17
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: RPL17 (ribosomal protein L17)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, nucleus, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P18621
Entrez ID: 6139
|
Does Knockout of ZNF599 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
ZNF599
|
response to chemicals
|
Melanoma Cell Line
|
Gene: ZNF599 (zinc finger protein 599)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q96NL3
Entrez ID: 148103
|
Does Knockout of RAN in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
RAN
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: RAN (RAN, member RAS oncogene family)
Type: protein-coding
Summary: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA metabolic process, GTP metabolic process, actin cytoskeleton organization, cell division, cellular response to mineralocorticoid stimulus, glycolytic process, hippocampus development, intracellular protein localization, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle organization, nucleocytoplasmic transport, positive regulation of protein import into nucleus, pre-miRNA export from nucleus, protein export from nucleus, protein import into nucleus, protein localization to nucleolus, protein transport, protein-containing complex localization, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus, ribosomal subunit export from nucleus, snRNA import into nucleus, spermatid development, viral process; MF: G protein activity, GDP binding, GTP binding, GTPase activity, RNA binding, cadherin binding, chromatin binding, dynein intermediate chain binding, hydrolase activity, importin-alpha family protein binding, magnesium ion binding, metal ion binding, nuclear export signal receptor activity, nucleotide binding, pre-miRNA binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein-containing complex binding; CC: Flemming body, RNA nuclear export complex, centriole, chromatin, cytoplasm, cytosol, extracellular exosome, male germ cell nucleus, manchette, melanosome, membrane, midbody, nuclear envelope, nuclear pore, nucleolus, nucleoplasm, nucleus, protein-containing complex, recycling endosome, sperm flagellum
Pathways: 22q11.2 copy number variation syndrome, Androgen receptor signaling pathway, AndrogenReceptor, Aurora A signaling, Canonical NF-kappaB pathway, Cell Cycle, Cell Cycle, Mitotic, Disease, Export of Viral Ribonucleoproteins from Nucleus, Fibroblast growth factor-1, FoxO family signaling, Gene Silencing by RNA, Gene expression (Transcription), HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Infectious disease, Influenza Infection, Interactions of Rev with host cellular proteins, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of lipids, Metabolism of steroids, MicroRNA (miRNA) biogenesis, Mitotic Anaphase, Mitotic Metaphase and Anaphase, NEP/NS2 Interacts with the Cellular Export Machinery, Nuclear Envelope (NE) Reassembly, Nuclear import of Rev protein, Postmitotic nuclear pore complex (NPC) reformation, RNA transport - Homo sapiens (human), Regulation of cholesterol biosynthesis by SREBP (SREBF), Rev-mediated nuclear export of HIV RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Role of Calcineurin-dependent NFAT signaling in lymphocytes, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TCR, Transcriptional regulation by small RNAs, Viral Infection Pathways, cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, miRNA Biogenesis, role of ran in mitotic spindle regulation, sumoylation by ranbp2 regulates transcriptional repression, tRNA processing, tRNA processing in the nucleus
UniProt: P62826
Entrez ID: 5901
|
Does Knockout of FNBP1L in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
FNBP1L
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: FNBP1L (formin binding protein 1 like)
Type: protein-coding
Summary: The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: autophagy, cilium assembly, clathrin-dependent endocytosis, endocytosis, membrane invagination, plasma membrane tubulation, positive regulation of filopodium assembly, signal transduction, vesicle budding from membrane, vesicle organization, vesicle transport along actin filament; MF: GTPase binding, cadherin binding, lipid binding, protein binding; CC: cell cortex, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, membrane, plasma membrane
Pathways: CDC42 GTPase cycle, Clathrin-mediated endocytosis, Membrane Trafficking, RHO GTPase cycle, RHOJ GTPase cycle, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q5T0N5
Entrez ID: 54874
|
Does Knockout of UPK1A in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
UPK1A
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: UPK1A (uroplakin 1A)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
Gene Ontology: CC: apical plasma membrane, apical plasma membrane urothelial plaque, cell surface, endoplasmic reticulum, extracellular exosome, membrane, plasma membrane, protein-containing complex
Pathways: Attachment of bacteria to epithelial cells, Bacterial Infection Pathways, Biofilm formation, Disease, Infection with Enterobacteria, Infectious disease
UniProt: O00322
Entrez ID: 11045
|
Does Knockout of ZNF573 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
ZNF573
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: ZNF573 (zinc finger protein 573)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of macromolecule metabolic process, regulation of primary metabolic process, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q86YE8
Entrez ID: 126231
|
Does Knockout of ZC2HC1A in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
ZC2HC1A
|
response to virus
|
Lung Cancer Cell Line
|
Gene: ZC2HC1A (zinc finger C2HC-type containing 1A)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: Q96GY0
Entrez ID: 51101
|
Does Knockout of SYT11 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
SYT11
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: SYT11 (synaptotagmin 11)
Type: protein-coding
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010].
Gene Ontology: BP: autophagy, calcium ion regulated lysosome exocytosis, calcium-dependent activation of synaptic vesicle fusion, establishment of vesicle localization, learning, memory, negative regulation of cytokine production, negative regulation of dopamine secretion, negative regulation of endocytosis, negative regulation of interleukin-6 production, negative regulation of microglial cell activation, negative regulation of neurotransmitter secretion, negative regulation of phagocytosis, negative regulation of secretion by cell, negative regulation of tumor necrosis factor production, plasma membrane repair, positive regulation of protein localization to phagocytic vesicle, regulation of calcium ion-dependent exocytosis, regulation of defense response to bacterium, regulation of phagosome maturation, regulation of synaptic vesicle endocytosis, response to wounding, vesicle fusion, vesicle-mediated transport; MF: SNARE binding, beta-tubulin binding, calcium ion binding, calcium ion sensor activity, calcium-dependent phospholipid binding, identical protein binding, metal ion binding, protein binding, translation initiation factor binding, ubiquitin protein ligase binding; CC: Golgi apparatus, axon, cell projection, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendrite, dendritic spine, dopaminergic synapse, early phagosome, endosome, excitatory synapse, exocytic vesicle, inhibitory synapse, lysosomal membrane, lysosome, membrane, neuron projection, perikaryon, phagocytic cup, phagocytic vesicle, plasma membrane, postsynaptic density, presynapse, presynaptic active zone membrane, recycling endosome, recycling endosome membrane, synapse, synaptic vesicle, trans-Golgi network, vesicle
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Parkinson,s disease pathway, Vesicle-mediated transport
UniProt: Q9BT88
Entrez ID: 23208
|
Does Knockout of MIS18BP1 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
MIS18BP1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: MIS18BP1 (MIS18 binding protein 1)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be involved in cell division. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CENP-A containing chromatin assembly, cell division, pericentric heterochromatin organization; MF: DNA binding, protein binding; CC: CENP-A recruiting complex, chromosome, chromosome, centromeric region, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, Cyclin A/B1/B2 associated events during G2/M transition, Deposition of new CENPA-containing nucleosomes at the centromere, G2/M Transition, Mitotic G2-G2/M phases, Nucleosome assembly
UniProt: Q6P0N0
Entrez ID: 55320
|
Does Knockout of ZNF75A in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
ZNF75A
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: ZNF75A (zinc finger protein 75A)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q96N20
Entrez ID: 7627
|
Does Knockout of VMA21 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
VMA21
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: VMA21 (vacuolar ATPase assembly factor VMA21)
Type: protein-coding
Summary: This gene encodes a chaperone for assembly of lysosomal vacuolar ATPase.[provided by RefSeq, Jul 2012].
Gene Ontology: BP: lysosomal lumen acidification, vacuolar proton-transporting V-type ATPase complex assembly; CC: ER to Golgi transport vesicle membrane, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, lysosome, membrane
Pathways:
UniProt: Q3ZAQ7
Entrez ID: 203547
|
Does Knockout of VPS13D in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
VPS13D
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: VPS13D (vacuolar protein sorting 13 homolog D)
Type: protein-coding
Summary: This gene encodes a protein belonging to the vacuolar-protein-sorting-13 gene family. In yeast, vacuolar-protein-sorting-13 proteins are involved in trafficking of membrane proteins between the trans-Golgi network and the prevacuolar compartment. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode distinct isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: lipid transport, mitochondrion organization, positive regulation of mitophagy, protein retention in Golgi apparatus, protein targeting to vacuole; CC: extracellular exosome, mitochondrion
Pathways:
UniProt: Q5THJ4
Entrez ID: 55187
|
Does Knockout of KDM5C in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
KDM5C
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: KDM5C (lysine demethylase 5C)
Type: protein-coding
Summary: This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].
Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, rhythmic process; MF: DNA binding, dioxygenase activity, histone H3K4 demethylase activity, histone H3K4me/H3K4me2/H3K4me3 demethylase activity, histone demethylase activity, metal ion binding, oxidoreductase activity, protein binding, zinc ion binding; CC: chromatin, cytosol, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, Pathways in clear cell renal cell carcinoma
UniProt: P41229
Entrez ID: 8242
|
Does Knockout of EAF1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
EAF1
|
response to virus
|
Hepatoma Cell Line
|
Gene: EAF1 (ELL associated factor 1)
Type: protein-coding
Summary: Enables transcription elongation regulator activity. Involved in regulation of transcription elongation from RNA polymerase II promoter. Located in intercellular bridge and nuclear body. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of transcription elongation by RNA polymerase II, transcription elongation by RNA polymerase II; MF: protein binding, transcription elongation factor activity; CC: Cajal body, intercellular bridge, nuclear body, nuclear speck, nucleoplasm, nucleus, super elongation complex, transcription elongation factor complex
Pathways: Formation of RNA Pol II elongation complex , Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q96JC9
Entrez ID: 85403
|
Does Knockout of RFWD3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
RFWD3
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: RFWD3 (ring finger and WD repeat domain 3)
Type: protein-coding
Summary: Enables MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Located in nucleoplasm and site of DNA damage. Colocalizes with site of double-strand break. Implicated in Fanconi anemia. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via homologous recombination, interstrand cross-link repair, mitotic G1 DNA damage checkpoint signaling, protein ubiquitination, regulation of DNA damage checkpoint, replication fork processing, response to ionizing radiation; MF: MDM2/MDM4 family protein binding, metal ion binding, p53 binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: PML body, cytoplasm, nucleoplasm, nucleus, site of DNA damage, site of double-strand break
Pathways:
UniProt: Q6PCD5
Entrez ID: 55159
|
Does Knockout of FXYD6-FXYD2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
FXYD6-FXYD2
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: FXYD6-FXYD2 (FXYD6-FXYD2 readthrough)
Type: protein-coding
Summary: This locus represents naturally occurring read-through transcription between the neighboring FXYD domain-containing ion transport regulator 6 (GeneID 53826) and sodium/potassium-transporting ATPase subunit gamma (GeneID 486) genes on chromosome 11. One read-through transcript produces a fusion protein that shares sequence identity with each individual gene product, while another read-through transcript encodes a protein that has a distinct C-terminus and only shares sequence identity with the upstream locus (GeneID 53826). [provided by RefSeq, Aug 2011].
Gene Ontology:
Pathways:
UniProt: A0A0A6YYL5, A0A087WZ82
Entrez ID: 100533181
|
Does Knockout of PPP3R2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
PPP3R2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: PPP3R2 (protein phosphatase 3 regulatory subunit B, beta)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity and calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within penetration of zona pellucida. Predicted to be located in sperm mitochondrial sheath. Predicted to be part of calcineurin complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: calcineurin-mediated signaling, negative regulation of calcium ion import across plasma membrane, penetration of zona pellucida, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of calcium ion import across plasma membrane; MF: calcium ion binding, calcium-dependent protein serine/threonine phosphatase regulator activity, metal ion binding, phosphatase binding, protein binding; CC: calcineurin complex, cytosol, mitochondrion, protein serine/threonine phosphatase complex, sperm flagellum, sperm midpiece, sperm mitochondrial sheath
Pathways: Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amphetamine addiction - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Axon guidance - Homo sapiens (human), B cell receptor signaling pathway - Homo sapiens (human), C-type lectin receptor signaling pathway - Homo sapiens (human), Calcium signaling pathway - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Energy Metabolism, Glucagon signaling pathway - Homo sapiens (human), Glutamatergic synapse - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Initiation of transcription and translation elongation at the HIV-1 LTR, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Natural killer cell mediated cytotoxicity - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Osteoclast differentiation - Homo sapiens (human), Oxytocin signaling pathway - Homo sapiens (human), PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Renin secretion - Homo sapiens (human), T cell receptor signaling pathway - Homo sapiens (human), Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Tuberculosis - Homo sapiens (human), VEGF signaling pathway - Homo sapiens (human), Wnt signaling, Wnt signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: Q96LZ3
Entrez ID: 5535
|
Does Knockout of PTPMT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
PTPMT1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: PTPMT1 (protein tyrosine phosphatase mitochondrial 1)
Type: protein-coding
Summary: Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in regulation of intrinsic apoptotic signaling pathway. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cardiolipin biosynthetic process, lipid metabolic process, phosphatidylglycerol biosynthetic process, phospholipid biosynthetic process, regulation of intrinsic apoptotic signaling pathway; MF: hydrolase activity, phosphatidylglycerophosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity; CC: cytoplasm, membrane, mitochondrial inner membrane, mitochondrion, nucleus
Pathways: Glycerophospholipid biosynthesis, Inositol Metabolism, Metabolism, Metabolism of lipids, Phospholipid Biosynthesis, Phospholipid metabolism, Synthesis of PG, cardiolipin biosynthesis
UniProt: Q8WUK0
Entrez ID: 114971
|
Does Knockout of OLFML1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
OLFML1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: OLFML1 (olfactomedin like 1)
Type: protein-coding
Summary: Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q6UWY5
Entrez ID: 283298
|
Does Knockout of CHD4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
CHD4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: CHD4 (chromodomain helicase DNA binding protein 4)
Type: protein-coding
Summary: The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: chromatin organization, chromatin remodeling, double-strand break repair via homologous recombination, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, oxygen transport, positive regulation of DNA-templated transcription, regulation of cell fate specification, regulation of stem cell differentiation, regulation of synapse assembly, terminal button organization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent chromatin remodeler activity, DNA binding, DNA-binding transcription factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, histone binding, histone deacetylase binding, hydrolase activity, metal ion binding, nucleosomal DNA binding, nucleotide binding, protein binding, transcription coregulator binding, transcription corepressor activity, zinc ion binding; CC: NuRD complex, RNA polymerase II transcription regulator complex, centrosome, cerebellar granule cell to Purkinje cell synapse, chromatin, chromosome, telomeric region, cytoplasm, cytoskeleton, membrane, nucleoplasm, nucleus, protein-containing complex, site of DNA damage
Pathways: Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome, Human papillomavirus infection - Homo sapiens (human), Rett syndrome causing genes, Signaling events mediated by HDAC Class I, Viral carcinogenesis - Homo sapiens (human)
UniProt: Q14839
Entrez ID: 1108
|
Does Knockout of STN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
STN1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: STN1 (STN1 subunit of CST complex)
Type: protein-coding
Summary: OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009].
Gene Ontology: BP: negative regulation of telomere maintenance via telomerase, positive regulation of DNA replication, regulation of DNA metabolic process, telomere capping, telomere maintenance, telomere maintenance via telomere lengthening; MF: DNA binding, nucleic acid binding, protein binding, single-stranded DNA binding, single-stranded telomeric DNA binding, telomeric DNA binding; CC: CST complex, chromosome, chromosome, telomeric region, fibrillar center, intermediate filament cytoskeleton, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Lung fibrosis, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: Q9H668
Entrez ID: 79991
|
Does Knockout of MANF in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
MANF
|
cell proliferation
|
Bladder Carcinoma
|
Gene: MANF (mesencephalic astrocyte derived neurotrophic factor)
Type: protein-coding
Summary: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: ATF6-mediated unfolded protein response, dopaminergic neuron differentiation, neuron projection development, regulation of response to endoplasmic reticulum stress, response to unfolded protein, vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure; MF: RNA binding, growth factor activity, lipid binding, protein binding, sulfatide binding; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum lumen, extracellular region, extracellular space, nucleus, sarcoplasmic reticulum, sarcoplasmic reticulum lumen
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: P55145
Entrez ID: 7873
|
Does Knockout of SS18L2 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
SS18L2
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: SS18L2 (SS18 like 2)
Type: protein-coding
Summary: Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to SS18.[supplied by OMIM, Jul 2002].
Gene Ontology:
Pathways:
UniProt: Q9UHA2
Entrez ID: 51188
|
Does Knockout of CTCFL in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
CTCFL
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CTCFL (CCCTC-binding factor like)
Type: protein-coding
Summary: CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: chromatin organization, epigenetic regulation of gene expression, establishment of protein localization to chromatin, genomic imprinting, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, protein localization to chromosome, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription initiation-coupled chromatin remodeling; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin insulator sequence binding, histone binding, metal ion binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: chromosome, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Male infertility
UniProt: Q8NI51
Entrez ID: 140690
|
Does Knockout of CAMSAP1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
CAMSAP1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: CAMSAP1 (calmodulin regulated spectrin associated protein 1)
Type: protein-coding
Summary: Enables microtubule minus-end binding activity and spectrin binding activity. Involved in several processes, including neuron projection development; regulation of cell morphogenesis; and regulation of microtubule polymerization. Located in microtubule. Colocalizes with microtubule minus-end. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoskeleton organization, microtubule cytoskeleton organization, neuron projection development, regulation of cell morphogenesis, regulation of microtubule polymerization; MF: calmodulin binding, microtubule binding, microtubule minus-end binding, protein binding, spectrin binding; CC: cytoplasm, cytoskeleton, microtubule, microtubule minus-end
Pathways:
UniProt: Q5T5Y3
Entrez ID: 157922
|
Does Knockout of SNRPG in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
SNRPG
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: SNRPG (small nuclear ribonucleoprotein polypeptide G)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: 7-methylguanosine cap hypermethylation, RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, spliceosomal complex assembly, spliceosomal snRNP assembly; MF: RNA binding, protein binding; CC: P granule, SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type prespliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, precatalytic spliceosome, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Disease, Gene expression (Transcription), Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Homo sapiens (human), Viral Infection Pathways, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62308
Entrez ID: 6637
|
Does Knockout of RRP12 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
RRP12
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RRP12 (ribosomal RNA processing 12 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in cytosol; nucleolus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding; CC: cytosol, membrane, nuclear membrane, nucleolus, nucleus, plasma membrane
Pathways:
UniProt: Q5JTH9
Entrez ID: 23223
|
Does Knockout of GYG2 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
GYG2
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: GYG2 (glycogenin 2)
Type: protein-coding
Summary: This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010].
Gene Ontology: BP: glycogen biosynthetic process; MF: glycogenin glucosyltransferase activity, glycosyltransferase activity, metal ion binding, protein binding, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Disease, Diseases of carbohydrate metabolism, Diseases of metabolism, Glycogen Synthesis and Degradation, Glycogen breakdown (glycogenolysis), Glycogen metabolism, Glycogen storage disease type 0 (liver GYS2), Glycogen storage disease type IV (GBE1), Glycogen storage diseases, Glycogen synthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Starch and sucrose metabolism - Homo sapiens (human), glycogen biosynthesis
UniProt: O15488
Entrez ID: 8908
|
Does Knockout of ERBB4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
ERBB4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ERBB4 (erb-b2 receptor tyrosine kinase 4)
Type: protein-coding
Summary: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ERBB2-ERBB4 signaling pathway, ERBB4 signaling pathway, ERBB4-ERBB4 signaling pathway, apoptotic process, cardiac muscle tissue regeneration, cell fate commitment, cell migration, cell surface receptor protein tyrosine kinase signaling pathway, cell surface receptor signaling pathway, cell surface receptor signaling pathway via JAK-STAT, cellular response to epidermal growth factor stimulus, central nervous system morphogenesis, embryonic pattern specification, epidermal growth factor receptor signaling pathway, establishment of planar polarity involved in nephron morphogenesis, heart development, lactation, mammary gland alveolus development, mammary gland development, mammary gland epithelial cell differentiation, mitochondrial fragmentation involved in apoptotic process, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of neuron migration, nervous system development, neural crest cell migration, neuron differentiation, neurotransmitter receptor localization to postsynaptic specialization membrane, olfactory bulb interneuron differentiation, peptidyl-tyrosine phosphorylation, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of biosynthetic process, positive regulation of cardiac muscle cell proliferation, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, positive regulation of phosphate metabolic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to cell surface, positive regulation of protein phosphorylation, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of tyrosine phosphorylation of STAT protein, protein autophosphorylation, regulation of biological quality, regulation of cell migration, signal transduction, synapse assembly; MF: ATP binding, GABA receptor binding, epidermal growth factor receptor activity, epidermal growth factor receptor binding, kinase activity, neuregulin receptor activity, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein tyrosine kinase activity, transcription cis-regulatory region binding, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: GABA-ergic synapse, basal plasma membrane, basolateral plasma membrane, cytosol, extracellular region, glutamatergic synapse, membrane, mitochondrial matrix, mitochondrion, neuromuscular junction, nucleoplasm, nucleus, organelle, plasma membrane, postsynaptic density membrane, postsynaptic membrane, presynaptic membrane, receptor complex
Pathways: Activation of NMDA receptors and postsynaptic events, Amyotrophic lateral sclerosis - Homo sapiens (human), Association Between Physico-Chemical Features and Toxicity Associated Pathways, Calcium signaling pathway - Homo sapiens (human), Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downregulation of ERBB2 signaling, Downregulation of ERBB4 signaling, ERBB2 Activates PTK6 Signaling, ERBB2 Regulates Cell Motility, ESR-mediated signaling, EV release from cardiac cells and their functional effects, ErbB receptor signaling network, ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), ErbB4 signaling events, Estrogen-dependent gene expression, GRB2 events in ERBB2 signaling, Long-term potentiation, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, Mammary gland development pathway - Embryonic development (Stage 1 of 4), Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4), Melanoma, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nuclear signaling by ERBB4, PI3K-Akt signaling pathway - Homo sapiens (human), Post NMDA receptor activation events, Prolactin, Proteoglycans in cancer - Homo sapiens (human), RAF/MAP kinase cascade, SHC1 events in ERBB2 signaling, SHC1 events in ERBB4 signaling, Signal Transduction, Signaling by ERBB2, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 TMD/JMD mutants, Signaling by ERBB2 in Cancer, Signaling by ERBB4, Signaling by Non-Receptor Tyrosine Kinases, Signaling by Nuclear Receptors, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Transmission across Chemical Synapses, g-secretase mediated erbb4 signaling pathway, role of erbb2 in signal transduction and oncology
UniProt: Q15303
Entrez ID: 2066
|
Does Knockout of ZNF564 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
ZNF564
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: ZNF564 (zinc finger protein 564)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q8TBZ8
Entrez ID: 163050
|
Does Knockout of GTSCR1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
GTSCR1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: GTSCR1 (Gilles de la Tourette syndrome chromosome region, candidate 1)
Type: ncRNA
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 220158
|
Does Knockout of ATP6V1D in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
ATP6V1D
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ATP6V1D (ATPase H+ transporting V1 subunit D)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi lumen acidification, cell projection organization, cilium assembly, endosomal lumen acidification, intracellular pH reduction, lysosomal lumen acidification, monoatomic ion transport, protein localization to cilium, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification, vacuolar acidification; MF: protein binding, proton-transporting ATPase activity, rotational mechanism; CC: Golgi membrane, cell projection, centrosome, cilium, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endosome membrane, extracellular exosome, extrinsic component of synaptic vesicle membrane, lysosomal membrane, membrane, nucleoplasm, plasma membrane, proton-transporting V-type ATPase complex, specific granule membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Neutrophil degranulation, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, mTOR signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: Q9Y5K8
Entrez ID: 51382
|
Does Knockout of EXOSC3 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
EXOSC3
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: EXOSC3 (exosome component 3)
Type: protein-coding
Summary: This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: CUT catabolic process, DNA deamination, DNA metabolic process, RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, U4 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), gene expression, isotype switching, mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear-transcribed mRNA catabolic process, poly(A)-dependent snoRNA 3'-end processing, positive regulation of isotype switching, rRNA processing, regulation of gene expression; MF: 3'-5'-RNA exonuclease activity, RNA binding, RNA exonuclease activity, protein binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, euchromatin, exosome (RNase complex), nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Cellular responses to stimuli, Cellular responses to stress, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, PERK regulates gene expression, RNA degradation - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, Unfolded Protein Response (UPR), mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NQT5
Entrez ID: 51010
|
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