prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of BTN2A1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | BTN2A1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: BTN2A1 (butyrophilin subfamily 2 member A1)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6. A pseudogene of... |
Does Knockout of EIF5A in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | EIF5A | cell proliferation | Gastric Cancer Cell Line | Gene: EIF5A (eukaryotic translation initiation factor 5A)
Type: protein-coding
Summary: Enables U6 snRNA binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 clas... |
Does Knockout of RPAP1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | RPAP1 | cell proliferation | Colonic Cancer Cell Line | Gene: RPAP1 (RNA polymerase II associated protein 1)
Type: protein-coding
Summary: This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012].
Gene Ontology: MF: DN... |
Does Knockout of CYP27B1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | CYP27B1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: CYP27B1 (cytochrome P450 family 27 subfamily B member 1)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, s... |
Does Knockout of SYNPO2L in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | SYNPO2L | cell proliferation | Breast Cancer Cell Line | Gene: SYNPO2L (synaptopodin 2 like)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Predicted to be involved in several processes, including positive regulation of Rho protein signal transduction; positive regulation of stress fiber assembly; and sarcomere organization. Located... |
Does Knockout of BUB1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | BUB1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: BUB1 (BUB1 mitotic checkpoint serine/threonine kinase)
Type: protein-coding
Summary: This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindl... |
Does Knockout of RYR1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | RYR1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: RYR1 (ryanodine receptor 1)
Type: protein-coding
Summary: This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations... |
Does Knockout of PKDREJ in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | PKDREJ | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: PKDREJ (polycystin family receptor for egg jelly)
Type: protein-coding
Summary: This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) ... |
Does Knockout of RAD21 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | RAD21 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: RAD21 (RAD21 cohesin complex component)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein ... |
Does Inhibition of NDUFB2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,184 | Inhibition | NDUFB2 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: NDUFB2 (NADH:ubiquinone oxidoreductase subunit B2)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and ... |
Does Activation of BET1 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | BET1 | protein/peptide accumulation | T cell | Gene: BET1 (Bet1 golgi vesicular membrane trafficking protein)
Type: protein-coding
Summary: This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide... |
Does Knockout of BRWD3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | BRWD3 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: BRWD3 (bromodomain and WD repeat domain containing 3)
Type: protein-coding
Summary: The protein encoded by this gene contains a bromodomain and several WD repeats. It is thought to have a chromatin-modifying function, and may thus play a role in transcription. Mutations in this gene are associated... |
Does Knockout of UBE2Q2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | UBE2Q2 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: UBE2Q2 (ubiquitin conjugating enzyme E2 Q2)
Type: protein-coding
Summary: Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of METTL2A in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | METTL2A | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: METTL2A (methyltransferase 2A, tRNA N3-cytidine)
Type: protein-coding
Summary: Enables tRNA (cytosine-3-)-methyltransferase activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: methylation, tRNA metabolic process, tRNA methylation... |
Does Knockout of GPX2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | GPX2 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: GPX2 (glutathione peroxidase 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative da... |
Does Knockout of POP4 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | POP4 | cell proliferation | Glioblastoma Cell Line | Gene: POP4 (POP4 ribonuclease P/MRP subunit)
Type: protein-coding
Summary: This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to t... |
Does Knockout of ZAP70 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | ZAP70 | response to chemicals | Glioblastoma Cell Line | Gene: ZAP70 (zeta chain of T cell receptor associated protein kinase 70)
Type: protein-coding
Summary: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residu... |
Does Knockout of C4BPB in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | C4BPB | cell proliferation | Breast Cancer Cell Line | Gene: C4BPB (complement component 4 binding protein beta)
Type: protein-coding
Summary: This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles w... |
Does Knockout of SAE1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | SAE1 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: SAE1 (SUMO1 activating enzyme subunit 1)
Type: protein-coding
Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterod... |
Does Knockout of SAE1 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | SAE1 | cell proliferation | Cancer Cell Line | Gene: SAE1 (SUMO1 activating enzyme subunit 1)
Type: protein-coding
Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterod... |
Does Knockout of RPL7 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | RPL7 | response to chemicals | Monocytic Leukemia Cell Line | Gene: RPL7 (ribosomal protein L7)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ... |
Does Knockout of YPEL5 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,631 | Knockout | YPEL5 | response to chemicals | Non-Small Cell Lung Adenocarcinoma Cell Line | Gene: YPEL5 (yippee like 5)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in cell population proliferation. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, prote... |
Does Knockout of GPATCH2L in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | GPATCH2L | cell proliferation | Monocytic Leukemia Cell Line | Gene: GPATCH2L (G-patch domain containing 2 like)
Type: protein-coding
Summary: Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q9NWQ4
Entrez ID: 55668 |
Does Knockout of CEMIP in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | CEMIP | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: CEMIP (cell migration inducing hyaluronidase 1)
Type: protein-coding
Summary: Enables several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process;... |
Does Knockout of GPR173 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | GPR173 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: GPR173 (G protein-coupled receptor 173)
Type: protein-coding
Summary: This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009].
Gene Ontology: BP: G protein-coupled ... |
Does Knockout of MRGPRX1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | MRGPRX1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: MRGPRX1 (MAS related GPR family member X1)
Type: protein-coding
Summary: Enables transmembrane signaling receptor activity. Involved in cell surface receptor signaling pathway and response to chloroquine. Predicted to be located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]... |
Does Knockout of KANK4 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | KANK4 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: KANK4 (KN motif and ankyrin repeat domains 4)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of actin filament polymerization. Located in cytosol and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative r... |
Does Knockout of MT3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | MT3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: MT3 (metallothionein 3)
Type: protein-coding
Summary: This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tiss... |
Does Knockout of KLHL11 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | KLHL11 | cell proliferation | Glioblastoma Cell Line | Gene: KLHL11 (kelch like family member 11)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, cytopla... |
Does Knockout of GRB2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | GRB2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: GRB2 (growth factor receptor bound protein 2)
Type: protein-coding
Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its... |
Does Knockout of KCNH1 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | KCNH1 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: KCNH1 (potassium voltage-gated channel subfamily H member 1)
Type: protein-coding
Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitt... |
Does Knockout of CACNA1S in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | CACNA1S | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: CACNA1S (calcium voltage-gated channel subunit alpha1 S)
Type: protein-coding
Summary: This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic para... |
Does Knockout of KRI1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | KRI1 | cell proliferation | Bladder Carcinoma | Gene: KRI1 (KRI1 homolog)
Type: protein-coding
Summary: This gene overlaps with the gene for cysteine endopeptidase AUT-like 4 in a head-to-tail orientation. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: 90S preribosome, nucleolus
Pathways:
UniProt: Q8N9T8
Entrez... |
Does Knockout of UBE2N in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | UBE2N | cell proliferation | Monocytic Leukemia Cell Line | Gene: UBE2N (ubiquitin conjugating enzyme E2 N)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enz... |
Does Knockout of RPS19BP1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | RPS19BP1 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: RPS19BP1 (ribosomal protein S19 binding protein 1)
Type: protein-coding
Summary: Enables enzyme binding activity. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, enzyme binding, protein binding; CC: cytos... |
Does Knockout of DCK in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | DCK | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: DCK (deoxycytidine kinase)
Type: protein-coding
Summary: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, in... |
Does Knockout of NSUN4 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | NSUN4 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: NSUN4 (NOP2/Sun RNA methyltransferase 4)
Type: protein-coding
Summary: Enables rRNA (cytosine-C5-)-methyltransferase activity. Involved in rRNA methylation. Part of mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA methylati... |
Does Knockout of FEN1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | FEN1 | cell proliferation | Gastric Cancer Cell Line | Gene: FEN1 (flap structure-specific endonuclease 1)
Type: protein-coding
Summary: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclea... |
Does Knockout of PIP4K2A in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | PIP4K2A | cell proliferation | Gastric Cancer Cell Line | Gene: PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha)
Type: protein-coding
Summary: Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferatio... |
Does Knockout of SARS2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | SARS2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: SARS2 (seryl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis o... |
Does Knockout of TRIM49C in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | TRIM49C | cell proliferation | Breast Cancer Cell Line | Gene: TRIM49C (tripartite motif containing 49C)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance o... |
Does Knockout of KPNA7 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | KPNA7 | cell proliferation | Endometrial Cancer Cell Line | Gene: KPNA7 (karyopherin subunit alpha 7)
Type: protein-coding
Summary: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore b... |
Does Knockout of LBX1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | LBX1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: LBX1 (ladybird homeobox 1)
Type: protein-coding
Summary: This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisitio... |
Does Knockout of CDC26 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | CDC26 | cell proliferation | Multiple Myeloma Cell Line | Gene: CDC26 (cell division cycle 26)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regul... |
Does Knockout of BBS9 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | BBS9 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: BBS9 (Bardet-Biedl syndrome 9)
Type: protein-coding
Summary: This gene is downregulated by parathyroid hormone in osteoblastic cells, and therefore is thought to be involved in parathyroid hormone action in bones. The exact function of this gene has not yet been determined. Alternatively spliced t... |
Does Knockout of OR2A1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | OR2A1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: OR2A1 (olfactory receptor family 2 subfamily A member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of WDR3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | WDR3 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: WDR3 (WD repeat domain 3)
Type: protein-coding
Summary: This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD... |
Does Knockout of PICALM in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | PICALM | cell proliferation | Endometrial Cancer Cell Line | Gene: PICALM (phosphatidylinositol binding clathrin assembly protein)
Type: protein-coding
Summary: This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may... |
Does Knockout of OR13F1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | OR13F1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: OR13F1 (olfactory receptor family 13 subfamily F member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of SIPA1L2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | SIPA1L2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: SIPA1L2 (signal induced proliferation associated 1 like 2)
Type: protein-coding
Summary: This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leuci... |
Does Knockout of PACS2 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | PACS2 | response to chemicals | Glioblastoma Cell Line | Gene: PACS2 (phosphofurin acidic cluster sorting protein 2)
Type: protein-coding
Summary: Predicted to enable transmembrane transporter binding activity. Involved in endoplasmic reticulum calcium ion homeostasis; mitochondrion-endoplasmic reticulum membrane tethering; and protein localization to plasma ... |
Does Knockout of REXO4 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | REXO4 | cell proliferation | Breast Cancer Cell Line | Gene: REXO4 (REX4 homolog, 3'-5' exonuclease)
Type: protein-coding
Summary: Enables DNA binding activity and nuclease activity. Involved in DNA catabolic process, endonucleolytic; DNA catabolic process, exonucleolytic; and DNA repair. Located in nuclear speck and nucleolus. [provided by Alliance of Geno... |
Does Knockout of FOXD4L1 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | FOXD4L1 | response to virus | Huh-7 Cell | Gene: FOXD4L1 (forkhead box D4 like 1)
Type: protein-coding
Summary: This gene is a member of the forkhead/winged-helix (FOX) family of transcription factors with highly conserved FOX DNA-binding domains. Members of the FOX family of transcription factors are regulators of embryogenesis and may play a r... |
Does Knockout of DNLZ in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | DNLZ | cell proliferation | Astrocytoma Cell Line | Gene: DNLZ (DNL-type zinc finger)
Type: protein-coding
Summary: Predicted to enable chaperone binding activity. Predicted to be involved in protein folding; protein import into mitochondrial matrix; and protein stabilization. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Reso... |
Does Knockout of MMP20 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | MMP20 | response to virus | Hepatoma Cell Line | Gene: MMP20 (matrix metallopeptidase 20)
Type: protein-coding
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease ... |
Does Knockout of SMARCE1 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | SMARCE1 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: SMARCE1 (SWI/SNF related BAF chromatin remodeling complex subunit E1)
Type: protein-coding
Summary: The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. T... |
Does Knockout of LMAN1L in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | LMAN1L | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: LMAN1L (lectin, mannose binding 1 like)
Type: protein-coding
Summary: This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This le... |
Does Knockout of SBNO1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | SBNO1 | cell proliferation | Endometrial Cancer Cell Line | Gene: SBNO1 (strawberry notch homolog 1)
Type: protein-coding
Summary: Predicted to enable chromatin DNA binding activity and histone binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Ap... |
Does Knockout of TEX14 in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | TEX14 | cell proliferation | Prostate Cancer Cell Line | Gene: TEX14 (testis expressed 14, intercellular bridge forming factor)
Type: protein-coding
Summary: The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for th... |
Does Knockout of POLA2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | POLA2 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: POLA2 (DNA polymerase alpha 2, accessory subunit)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Involved in DNA replication, synthesis of RNA primer. Located in cytosol and nucleoplasm. Part of alpha DNA polymerase:primase complex. [provided by Alliance of Genome Resource... |
Does Knockout of CRYGA in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | CRYGA | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: CRYGA (crystallin gamma A)
Type: protein-coding
Summary: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central... |
Does Knockout of FTSJ1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | FTSJ1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1)
Type: protein-coding
Summary: This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations... |
Does Knockout of WDR5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | WDR5 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: WDR5 (WD repeat domain 5)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or mul... |
Does Knockout of YBX2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | YBX2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: YBX2 (Y-box binding protein 2)
Type: protein-coding
Summary: This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for... |
Does Knockout of NKIRAS1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | NKIRAS1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: NKIRAS1 (NFKB inhibitor interacting Ras like 1)
Type: protein-coding
Summary: Predicted to enable GTPase activating protein binding activity. Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within several processes, including Ral protein signal tran... |
Does Activation of CDX4 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | CDX4 | response to virus | Hepatoma Cell Line | Gene: CDX4 (caudal type homeobox 4)
Type: protein-coding
Summary: This gene encodes a member of a small subfamily of homeobox containing transcription factors. The encoded protein may regulate homeobox gene expression during anteroposterior patterning and hematopoiesis. [provided by RefSeq, Aug 2012].
... |
Does Knockout of GLRX5 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | GLRX5 | cell proliferation | Endometrial Cancer Cell Line | Gene: GLRX5 (glutaredoxin 5)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessiv... |
Does Knockout of RPL17 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | RPL17 | cell proliferation | Gastric Cancer Cell Line | Gene: RPL17 (ribosomal protein L17)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of ZNF599 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | ZNF599 | response to chemicals | Melanoma Cell Line | Gene: ZNF599 (zinc finger protein 599)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation ... |
Does Knockout of RAN in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | RAN | cell proliferation | Astrocytoma Cell Line | Gene: RAN (RAN, member RAS oncogene family)
Type: protein-coding
Summary: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in co... |
Does Knockout of FNBP1L in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | FNBP1L | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: FNBP1L (formin binding protein 1 like)
Type: protein-coding
Summary: The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signa... |
Does Knockout of UPK1A in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | UPK1A | cell proliferation | Gastric Cancer Cell Line | Gene: UPK1A (uroplakin 1A)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins... |
Does Knockout of ZNF573 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | ZNF573 | response to chemicals | Colorectal Cancer Cell Line | Gene: ZNF573 (zinc finger protein 573)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of ZC2HC1A in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | ZC2HC1A | response to virus | Lung Cancer Cell Line | Gene: ZC2HC1A (zinc finger C2HC-type containing 1A)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: Q9... |
Does Knockout of SYT11 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | SYT11 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: SYT11 (synaptotagmin 11)
Type: protein-coding
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded ... |
Does Knockout of MIS18BP1 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | MIS18BP1 | cell proliferation | Breast Cancer Cell Line | Gene: MIS18BP1 (MIS18 binding protein 1)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be involved in cell division. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CENP-A containing chromatin... |
Does Knockout of ZNF75A in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | ZNF75A | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: ZNF75A (zinc finger protein 75A)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2... |
Does Knockout of VMA21 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | VMA21 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: VMA21 (vacuolar ATPase assembly factor VMA21)
Type: protein-coding
Summary: This gene encodes a chaperone for assembly of lysosomal vacuolar ATPase.[provided by RefSeq, Jul 2012].
Gene Ontology: BP: lysosomal lumen acidification, vacuolar proton-transporting V-type ATPase complex assembly... |
Does Knockout of VPS13D in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | VPS13D | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: VPS13D (vacuolar protein sorting 13 homolog D)
Type: protein-coding
Summary: This gene encodes a protein belonging to the vacuolar-protein-sorting-13 gene family. In yeast, vacuolar-protein-sorting-13 proteins are involved in trafficking of membrane proteins between the trans-Golgi network and the... |
Does Knockout of KDM5C in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | KDM5C | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: KDM5C (lysine demethylase 5C)
Type: protein-coding
Summary: This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of tran... |
Does Knockout of EAF1 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | EAF1 | response to virus | Hepatoma Cell Line | Gene: EAF1 (ELL associated factor 1)
Type: protein-coding
Summary: Enables transcription elongation regulator activity. Involved in regulation of transcription elongation from RNA polymerase II promoter. Located in intercellular bridge and nuclear body. Part of transcription elongation factor complex. [... |
Does Knockout of RFWD3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | RFWD3 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: RFWD3 (ring finger and WD repeat domain 3)
Type: protein-coding
Summary: Enables MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and re... |
Does Knockout of FXYD6-FXYD2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | FXYD6-FXYD2 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: FXYD6-FXYD2 (FXYD6-FXYD2 readthrough)
Type: protein-coding
Summary: This locus represents naturally occurring read-through transcription between the neighboring FXYD domain-containing ion transport regulator 6 (GeneID 53826) and sodium/potassium-transporting ATPase subunit gamma (GeneID 486) genes... |
Does Knockout of PPP3R2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | PPP3R2 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: PPP3R2 (protein phosphatase 3 regulatory subunit B, beta)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity and calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be involved in regulation of catalytic activity. Predicted to act ups... |
Does Knockout of PTPMT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | PTPMT1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: PTPMT1 (protein tyrosine phosphatase mitochondrial 1)
Type: protein-coding
Summary: Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in regulation of intrinsic apoptotic signaling pathway. Located in mitochondrio... |
Does Knockout of OLFML1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | OLFML1 | cell proliferation | Medulloblastoma Cell Line | Gene: OLFML1 (olfactomedin like 1)
Type: protein-coding
Summary: Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q6UWY5
Entrez ID: 283... |
Does Knockout of CHD4 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | CHD4 | cell proliferation | Melanoma Cell Line | Gene: CHD4 (chromodomain helicase DNA binding protein 4)
Type: protein-coding
Summary: The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repre... |
Does Knockout of STN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | STN1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: STN1 (STN1 subunit of CST complex)
Type: protein-coding
Summary: OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19... |
Does Knockout of MANF in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | MANF | cell proliferation | Bladder Carcinoma | Gene: MANF (mesencephalic astrocyte derived neurotrophic factor)
Type: protein-coding
Summary: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results... |
Does Knockout of SS18L2 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | SS18L2 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: SS18L2 (SS18 like 2)
Type: protein-coding
Summary: Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused i... |
Does Knockout of CTCFL in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | CTCFL | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: CTCFL (CCCTC-binding factor like)
Type: protein-coding
Summary: CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. ... |
Does Knockout of CAMSAP1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | CAMSAP1 | cell proliferation | Medulloblastoma Cell Line | Gene: CAMSAP1 (calmodulin regulated spectrin associated protein 1)
Type: protein-coding
Summary: Enables microtubule minus-end binding activity and spectrin binding activity. Involved in several processes, including neuron projection development; regulation of cell morphogenesis; and regulation of micro... |
Does Knockout of SNRPG in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | SNRPG | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: SNRPG (small nuclear ribonucleoprotein polypeptide G)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear rib... |
Does Knockout of RRP12 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | RRP12 | cell proliferation | Colonic Cancer Cell Line | Gene: RRP12 (ribosomal RNA processing 12 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in cytosol; nucleolus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding; CC:... |
Does Knockout of GYG2 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | GYG2 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: GYG2 (glycogenin 2)
Type: protein-coding
Summary: This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes t... |
Does Knockout of ERBB4 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | ERBB4 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ERBB4 (erb-b2 receptor tyrosine kinase 4)
Type: protein-coding
Summary: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosin... |
Does Knockout of ZNF564 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | ZNF564 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: ZNF564 (zinc finger protein 564)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted t... |
Does Knockout of GTSCR1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | GTSCR1 | cell proliferation | Glioblastoma Cell Line | Gene: GTSCR1 (Gilles de la Tourette syndrome chromosome region, candidate 1)
Type: ncRNA
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 220158 |
Does Knockout of ATP6V1D in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | ATP6V1D | cell proliferation | Medulloblastoma Cell Line | Gene: ATP6V1D (ATPase H+ transporting V1 subunit D)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intrac... |
Does Knockout of EXOSC3 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | EXOSC3 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: EXOSC3 (exosome component 3)
Type: protein-coding
Summary: This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromoso... |
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