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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of CCNK in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
CCNK
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: CCNK (cyclin K)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, cell division, host-mediated suppression of viral genome replication, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of cell cycle, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of signal transduction, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein binding, protein kinase binding; CC: cyclin K-CDK12 complex, cyclin K-CDK13 complex, cyclin-dependent protein kinase holoenzyme complex, cyclin/CDK positive transcription elongation factor complex, nucleoplasm, nucleus
Pathways: Direct p53 effectors, Male infertility
UniProt: O75909
Entrez ID: 8812
|
Does Knockout of TANGO6 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
TANGO6
|
cell proliferation
|
Bladder Carcinoma
|
Gene: TANGO6 (transport and golgi organization 6 homolog)
Type: protein-coding
Summary: Predicted to be involved in protein secretion. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q9C0B7
Entrez ID: 79613
|
Does Knockout of COPS6 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
COPS6
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: COPS6 (COP9 signalosome subunit 6)
Type: protein-coding
Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: protein deneddylation, protein neddylation, regulation of protein neddylation; MF: metal-dependent deubiquitinase activity, peptidase activity, protein binding; CC: COP9 signalosome, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Cargo recognition for clathrin-mediated endocytosis, Ciliary landscape, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Nucleotide-binding Oligomerization Domain (NOD) pathway, Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q7L5N1
Entrez ID: 10980
|
Does Knockout of SASS6 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
SASS6
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: SASS6 (SAS-6 centriolar assembly protein)
Type: protein-coding
Summary: The protein encoded by this gene is a central component of centrioles and is necessary for their duplication and function. Centrioles adopt a cartwheel-shaped structure, with the encoded protein forming the hub and spokes inside a microtubule cylinder. Defects in this gene are a cause of autosomal recessive primary microcephaly. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: centriole replication, centrosome duplication, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of centriole replication, positive regulation of spindle assembly, regulation of mitotic spindle organization, spermatogenesis; CC: centriole, centrosome, cytoplasm, cytoskeleton, deuterosome, procentriole replication complex
Pathways: Genes related to primary cilium development (based on CRISPR)
UniProt: Q6UVJ0
Entrez ID: 163786
|
Does Knockout of SYT14 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
SYT14
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: SYT14 (synaptotagmin 14)
Type: protein-coding
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011].
Gene Ontology: MF: identical protein binding, phospholipid binding
Pathways:
UniProt: Q8NB59
Entrez ID: 255928
|
Does Knockout of ASCL3 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
ASCL3
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: ASCL3 (achaete-scute family bHLH transcription factor 3)
Type: protein-coding
Summary: Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: animal organ development, epithelium development, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, salivary gland development, sensory epithelium regeneration, tissue homeostasis; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity; CC: RNA polymerase II transcription regulator complex, chromatin, nucleus, transcription regulator complex
Pathways:
UniProt: Q9NQ33
Entrez ID: 56676
|
Does Knockout of RHBDL1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
RHBDL1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RHBDL1 (rhomboid like 1)
Type: protein-coding
Summary: This gene encodes a protein similar to Rhomboid in Drosophila which is involved in signalling in the Spitz/epidermal growth factor receptor/mitogen-activated protein kinase pathway. The Rhomboid family of proteins consists of intramembrane serine proteases containing several transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: proteolysis, signal transduction; MF: hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: membrane, plasma membrane
Pathways:
UniProt: O75783
Entrez ID: 9028
|
Does Knockout of PPP1R13L in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
PPP1R13L
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PPP1R13L (protein phosphatase 1 regulatory subunit 13 like)
Type: protein-coding
Summary: IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008].
Gene Ontology: BP: apoptotic process, cardiac muscle contraction, cardiac right ventricle morphogenesis, embryonic camera-type eye development, hair cycle, multicellular organism growth, multicellular organismal-level homeostasis, negative regulation of inflammatory response, negative regulation of transcription by RNA polymerase II, positive regulation of cell differentiation, post-embryonic development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, ventricular cardiac muscle tissue development; MF: cadherin binding, identical protein binding, protein binding, transcription corepressor activity; CC: cell junction, cytoplasm, cytosol, intercellular bridge, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, IL-18 signaling pathway, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Association with Co-factors, TNFalpha, Transcriptional Regulation by TP53, p53 pathway
UniProt: Q8WUF5
Entrez ID: 10848
|
Does Knockout of BCR in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
BCR
|
cell proliferation
|
Cancer Cell Line
|
Gene: BCR (BCR activator of RhoGEF and GTPase)
Type: protein-coding
Summary: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020].
Gene Ontology: BP: actin cytoskeleton organization, activation of GTPase activity, brain development, cell migration, cellular response to lipopolysaccharide, definitive hemopoiesis, establishment of localization in cell, focal adhesion assembly, homeostasis of number of cells, inner ear morphogenesis, intracellular protein transmembrane transport, intracellular signal transduction, keratinocyte differentiation, macrophage migration, modulation of chemical synaptic transmission, negative regulation of blood vessel remodeling, negative regulation of cellular extravasation, negative regulation of inflammatory response, negative regulation of macrophage migration, negative regulation of neutrophil degranulation, negative regulation of reactive oxygen species metabolic process, negative regulation of respiratory burst, neuromuscular process controlling balance, neutrophil degranulation, phagocytosis, positive regulation of phagocytosis, protein phosphorylation, regulation of Rho protein signal transduction, regulation of cell cycle, regulation of small GTPase mediated signal transduction, regulation of vascular permeability, renal system process, response to lipopolysaccharide, signal transduction, small GTPase-mediated signal transduction; MF: ATP binding, GTPase activator activity, guanyl-nucleotide exchange factor activity, kinase activity, nucleotide binding, protein binding, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity; CC: Schaffer collateral - CA1 synapse, axon, cell projection, cytosol, dendritic spine, extracellular exosome, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, protein-containing complex, synapse
Pathways: Chronic myeloid leukemia - Homo sapiens (human), Imatinib and Chronic Myeloid Leukemia, Pathways in cancer - Homo sapiens (human), Regulation of RAC1 activity, Regulation of RhoA activity, bcr signaling pathway, ctcf: first multivalent nuclear factor, inhibition of cellular proliferation by gleevec, integrin signaling pathway
UniProt: P11274
Entrez ID: 613
|
Does Knockout of PNLIP in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
PNLIP
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PNLIP (pancreatic lipase)
Type: protein-coding
Summary: This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: cholesterol homeostasis, fatty acid biosynthetic process, high-density lipoprotein particle remodeling, intestinal cholesterol absorption, lipid catabolic process, lipid metabolic process, positive regulation of triglyceride lipase activity, retinoid metabolic process, retinol metabolic process, triglyceride catabolic process; MF: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity, carboxylic ester hydrolase activity, hydrolase activity, lipase activity, lipoprotein lipase activity, metal ion binding, phospholipase A1 activity, retinyl-palmitate esterase activity, triacylglycerol lipase activity; CC: extracellular region, extracellular space
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Pancreatic Acinar Cells, Digestion, Digestion and absorption, Digestion of dietary lipid, Fat digestion and absorption - Homo sapiens (human), Glycerolipid metabolism - Homo sapiens (human), Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Pancreatic secretion - Homo sapiens (human), Retinoid metabolism and transport, Sensory Perception, Visual phototransduction, Vitamin digestion and absorption - Homo sapiens (human), retinol biosynthesis, triacylglycerol degradation
UniProt: P16233
Entrez ID: 5406
|
Does Knockout of SLITRK6 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
SLITRK6
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: SLITRK6 (SLIT and NTRK like family member 6)
Type: protein-coding
Summary: This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: adult locomotory behavior, auditory behavior, auditory receptor cell morphogenesis, axonogenesis, camera-type eye development, cochlea development, inner ear morphogenesis, innervation, lens development in camera-type eye, linear vestibuloocular reflex, multicellular organism growth, neuron projection morphogenesis, positive regulation of synapse assembly, sensory perception of sound, startle response, synapse assembly, vestibular reflex, vestibulocochlear nerve development, visual perception; CC: cell periphery, cell surface, membrane, plasma membrane
Pathways: EGFR1, Neuronal System, Protein-protein interactions at synapses, Receptor-type tyrosine-protein phosphatases
UniProt: Q9H5Y7
Entrez ID: 84189
|
Does Knockout of RPS13 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
RPS13
|
cell proliferation
|
T-lymphoma cell line
|
Gene: RPS13 (ribosomal protein S13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, negative regulation of RNA splicing, ribosomal small subunit biogenesis, translation; MF: RNA binding, mRNA 5'-UTR binding, mRNA binding, protein binding, small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome, small-subunit processome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, TNFalpha, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62277
Entrez ID: 6207
|
Does Knockout of SF1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
SF1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SF1 (splicing factor 1)
Type: protein-coding
Summary: This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: RNA splicing, mRNA 3'-splice site recognition, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, negative regulation of DNA-templated transcription, negative regulation of smooth muscle cell proliferation, regulation of primary metabolic process, spliceosomal complex assembly; MF: RNA binding, identical protein binding, mRNA binding, metal ion binding, nucleic acid binding, protein binding, transcription corepressor activity, zinc ion binding; CC: U2AF complex, nucleoplasm, nucleus, ribosome, spliceosomal complex
Pathways: AndrogenReceptor
UniProt: Q15637
Entrez ID: 7536
|
Does Knockout of SEC23B in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
SEC23B
|
cell proliferation
|
Cancer Cell Line
|
Gene: SEC23B (SEC23 homolog B, COPII component)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010].
Gene Ontology: BP: COPII-coated vesicle budding, COPII-coated vesicle cargo loading, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein transport, vesicle-mediated transport; MF: GTPase activator activity, metal ion binding, protein binding, zinc ion binding; CC: COPII vesicle coat, ER to Golgi transport vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, membrane, perinuclear region of cytoplasm
Pathways: Protein processing in endoplasmic reticulum - Homo sapiens (human), Sterol regulatory element-binding proteins (SREBP) signaling
UniProt: Q15437
Entrez ID: 10483
|
Does Knockout of TCF20 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
TCF20
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: TCF20 (transcription factor 20)
Type: protein-coding
Summary: This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, RNA binding, metal ion binding, protein binding, zinc ion binding; CC: nuclear body, nucleoplasm, nucleus
Pathways: Matrix Metalloproteinases
UniProt: Q9UGU0
Entrez ID: 6942
|
Does Activation of CBX4 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
CBX4
|
protein/peptide accumulation
|
T cell
|
Gene: CBX4 (chromobox 4)
Type: protein-coding
Summary: Enables SUMO binding activity; SUMO ligase activity; and enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, protein sumoylation; MF: SUMO binding, SUMO ligase activity, SUMO transferase activity, chromatin binding, enzyme binding, phosphoprotein binding, protein binding, single-stranded RNA binding, transcription cis-regulatory region binding, transcription corepressor activity, transferase activity; CC: PRC1 complex, PcG protein complex, nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways: C-MYB transcription factor network, Regulation of retinoblastoma protein, the prc2 complex sets long-term gene silencing through modification of histone tails
UniProt: O00257
Entrez ID: 8535
|
Does Knockout of AURKB in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
AURKB
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: AURKB (aurora kinase B)
Type: protein-coding
Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, cGAS/STING signaling pathway, cell cycle G2/M phase transition, cell division, cellular response to UV, cleavage furrow formation, midbody abscission, mitotic cell cycle, mitotic cytokinesis, mitotic cytokinesis checkpoint signaling, mitotic sister chromatid biorientation, mitotic spindle assembly, mitotic spindle midzone assembly, mitotic spindle organization, negative regulation of B cell apoptotic process, negative regulation of cGAS/STING signaling pathway, negative regulation of cytokinesis, negative regulation of innate immune response, negative regulation of transcription by RNA polymerase II, positive regulation of attachment of mitotic spindle microtubules to kinetochore, positive regulation of cell cycle process, positive regulation of cytokinesis, positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore, positive regulation of microtubule depolymerization, positive regulation of mitotic cell cycle spindle assembly checkpoint, positive regulation of mitotic cytokinesis, positive regulation of mitotic sister chromatid segregation, positive regulation of mitotic sister chromatid separation, positive regulation of telomere maintenance, post-translational protein modification, protein localization to kinetochore, regulation of chromosome segregation, regulation of cytokinesis, regulation of microtubule-based process, regulation of signal transduction by p53 class mediator, repair of mitotic kinetochore microtubule attachment defect, spindle organization; MF: ATP binding, kinase activity, kinase binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, transferase activity; CC: centrosome, chromocenter, chromosome, chromosome passenger complex, chromosome, centromeric region, condensed chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, microtubule cytoskeleton, midbody, mitotic spindle midzone, mitotic spindle pole, nucleoplasm, nucleus, spindle, spindle microtubule, spindle midzone, spindle pole
Pathways: APC/C-mediated degradation of cell cycle proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, ATM Signaling Network in Development and Disease, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Aurora A signaling, Aurora B signaling, Aurora C signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, FOXM1 transcription factor network, Gene expression (Transcription), Generic Transcription Pathway, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, Regulation of MECP2 expression and activity, Regulation of Microtubule Cytoskeleton, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of mitotic cell cycle, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional Regulation by MECP2, Transcriptional Regulation by TP53
UniProt: Q96GD4
Entrez ID: 9212
|
Does Knockout of NUFIP1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
NUFIP1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: NUFIP1 (nuclear FMR1 interacting protein 1)
Type: protein-coding
Summary: This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: RNA processing, box C/D snoRNP assembly, positive regulation of transcription by RNA polymerase II; MF: ATPase binding, DNA binding, RNA binding, identical protein binding, metal ion binding, protein binding, protein-macromolecule adaptor activity, snoRNA binding, zinc ion binding; CC: fibrillar center, nuclear matrix, nucleolus, nucleoplasm, nucleus, perichromatin fibrils, pre-snoRNP complex, presynaptic active zone, protein-containing complex, synapse, transcription elongation factor complex
Pathways:
UniProt: Q9UHK0
Entrez ID: 26747
|
Does Knockout of OVGP1 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
OVGP1
|
response to virus
|
Lung Cancer Cell Line
|
Gene: OVGP1 (oviductal glycoprotein 1)
Type: protein-coding
Summary: This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate metabolic process, chitin catabolic process, female pregnancy, negative regulation of binding of sperm to zona pellucida, single fertilization; MF: chitin binding, chitinase activity; CC: cytoplasmic vesicle, cytosol, egg coat, extracellular region, microtubule cytoskeleton, perivitelline space, transport vesicle
Pathways: Fertilization, Interaction With Cumulus Cells And The Zona Pellucida, Reproduction
UniProt: Q12889
Entrez ID: 5016
|
Does Knockout of CXCR6 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
CXCR6
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: CXCR6 (C-X-C motif chemokine receptor 6)
Type: protein-coding
Summary: The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium-mediated signaling, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, immune response, inflammatory response, positive regulation of cytosolic calcium ion concentration, signal transduction, viral genome replication; MF: C-C chemokine binding, C-C chemokine receptor activity, C-X-C chemokine receptor activity, G protein-coupled receptor activity, chemokine receptor activity, coreceptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Homo sapiens (human), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide GPCRs, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: O00574
Entrez ID: 10663
|
Does Knockout of DKC1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
DKC1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: DKC1 (dyskerin pseudouridine synthase 1)
Type: protein-coding
Summary: This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: RNA modification, RNA processing, box H/ACA sno(s)RNA 3'-end processing, box H/ACA sno(s)RNA metabolic process, enzyme-directed rRNA pseudouridine synthesis, mRNA pseudouridine synthesis, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein localization to Cajal body, pseudouridine synthesis, rRNA processing, rRNA pseudouridine synthesis, regulation of telomerase RNA localization to Cajal body, ribosome biogenesis, scaRNA localization to Cajal body, snRNA pseudouridine synthesis, telomerase RNA stabilization, telomerase holoenzyme complex assembly, telomere maintenance via telomerase; MF: RNA binding, box H/ACA snoRNA binding, isomerase activity, protein binding, pseudouridine synthase activity, telomerase RNA binding, telomerase activity; CC: Cajal body, box H/ACA scaRNP complex, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, cytoplasm, fibrillar center, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Metabolism of RNA, Regulation of Telomerase, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Telomere Extension By Telomerase, Telomere Maintenance, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O60832
Entrez ID: 1736
|
Does Knockout of HCRTR1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
HCRTR1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: HCRTR1 (hypocretin receptor 1)
Type: protein-coding
Summary: The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to hormone stimulus, chemical synaptic transmission, feeding behavior, neuropeptide signaling pathway, positive regulation of ERK1 and ERK2 cascade, regulation of cytosolic calcium ion concentration, signal transduction; MF: G protein-coupled receptor activity, orexin receptor activity, peptide hormone binding, protein binding; CC: membrane, plasma membrane, synapse
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Neuroactive ligand-receptor interaction - Homo sapiens (human), Orexin and neuropeptides FF and QRFP bind to their respective receptors, Peptide GPCRs, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: O43613
Entrez ID: 3061
|
Does Knockout of MCAT in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
MCAT
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: MCAT (malonyl-CoA-acyl carrier protein transacylase)
Type: protein-coding
Summary: The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: fatty acid beta-oxidation, fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, mitochondrial small ribosomal subunit assembly, monocarboxylic acid metabolic process; MF: RNA binding, [acyl-carrier-protein] S-malonyltransferase activity, transferase activity; CC: mitochondrial matrix, mitochondrion
Pathways: Fatty acid biosynthesis - Homo sapiens (human), Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, Mitochondrial fatty acid synthesis pathway, fatty acid biosynthesis initiation
UniProt: Q8IVS2
Entrez ID: 27349
|
Does Activation of AP5Z1 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
AP5Z1
|
protein/peptide accumulation
|
T cell
|
Gene: AP5Z1 (adaptor related protein complex 5 subunit zeta 1)
Type: protein-coding
Summary: This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011].
Gene Ontology: BP: DNA damage response, DNA repair, Golgi organization, autophagosome assembly, autophagy, axon development, double-strand break repair via homologous recombination, endosomal transport, gene expression, intracellular protein transport, late endosome to Golgi transport, lysosomal protein catabolic process, lysosome organization, protein transport, vesicle-mediated transport; CC: AP-5 adaptor complex, AP-type membrane coat adaptor complex, cytoplasm, late endosome, lysosome, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: O43299
Entrez ID: 9907
|
Does Knockout of UBA1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
UBA1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: UBA1 (ubiquitin like modifier activating enzyme 1)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, RNA binding, ligase activity, nucleotide binding, protein binding, ubiquitin activating enzyme activity, ubiquitin-like modifier activating enzyme activity; CC: cytoplasm, cytosol, desmosome, endosome membrane, extracellular exosome, heterochromatin, lysosomal membrane, mitochondrion, nucleoplasm, nucleus, rough endoplasmic reticulum membrane
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Parkinson,s disease pathway, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Proteasome Degradation, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Homo sapiens (human), fibrinolysis pathway, gamma-aminobutyric acid receptor life cycle pathway, proteasome complex, sumoylation as a mechanism to modulate ctbp-dependent gene responses
UniProt: P22314
Entrez ID: 7317
|
Does Knockout of ATP6AP2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
ATP6AP2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ATP6AP2 (ATPase H+ transporting accessory protein 2)
Type: protein-coding
Summary: This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi lumen acidification, angiotensin maturation, central nervous system maturation, endosomal lumen acidification, eye pigmentation, head morphogenesis, intracellular pH reduction, lysosomal lumen acidification, positive regulation of Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of transforming growth factor beta1 production, proton transmembrane transport, regulation of MAPK cascade, rostrocaudal neural tube patterning, synaptic vesicle lumen acidification, vacuolar acidification; MF: protein binding, signaling receptor activity; CC: Golgi membrane, autophagosome membrane, axon, bounding membrane of organelle, cell projection, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, dendritic spine membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, external side of plasma membrane, extracellular exosome, ficolin-1-rich granule membrane, lysosomal membrane, lysosome, membrane, plasma membrane, postsynaptic membrane, proton-transporting V-type ATPase complex, synapse, synaptic vesicle membrane, tertiary granule membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: ACE Inhibitor Pathway, Immune System, Innate Immune System, Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, Neutrophil degranulation, Oxidative phosphorylation, Peptide hormone metabolism, Renin-angiotensin system - Homo sapiens (human), Wnt signaling network
UniProt: O75787
Entrez ID: 10159
|
Does Knockout of SEC61A1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
SEC61A1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SEC61A1 (SEC61 translocon subunit alpha 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, translocation, calcium ion transmembrane transport, cotranslational protein targeting to membrane, endoplasmic reticulum organization, post-translational protein targeting to endoplasmic reticulum membrane, post-translational protein targeting to membrane, translocation, pronephric nephron development, protein insertion into ER membrane, protein targeting to ER, protein transport, response to type II interferon; MF: calcium channel activity, protein binding, protein transmembrane transporter activity, ribosome binding, signal sequence binding; CC: Sec61 translocon complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, ER-Phagosome pathway, Immune System, Metabolism of proteins, Phagosome - Homo sapiens (human), Protein export - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), SRP-dependent cotranslational protein targeting to membrane, Translation, Vibrio cholerae infection - Homo sapiens (human), er associated degradation (erad) pathway
UniProt: P61619
Entrez ID: 29927
|
Does Knockout of ACTL9 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
ACTL9
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: ACTL9 (actin like 9)
Type: protein-coding
Summary: Predicted to be located in cytoplasm. Predicted to be part of dynactin complex. Implicated in spermatogenic failure 53. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: acrosome assembly, fertilization, single fertilization; CC: acrosomal vesicle, actin cytoskeleton, cytoplasm, cytoplasmic vesicle, cytoskeleton, perinuclear theca, sperm head
Pathways:
UniProt: Q8TC94
Entrez ID: 284382
|
Does Knockout of CXCL12 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
CXCL12
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: CXCL12 (C-X-C motif chemokine ligand 12)
Type: protein-coding
Summary: This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: CXCL12-activated CXCR4 signaling pathway, G protein-coupled receptor signaling pathway, T cell chemotaxis, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adult locomotory behavior, animal organ regeneration, antimicrobial humoral immune response mediated by antimicrobial peptide, axon guidance, blood circulation, cell adhesion, cell chemotaxis, cellular response to chemokine, chemokine (C-X-C motif) ligand 12 signaling pathway, chemokine-mediated signaling pathway, chemotaxis, defense response, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, immune response, induction of positive chemotaxis, integrin activation, intracellular calcium ion homeostasis, killing of cells of another organism, negative regulation of dendritic cell apoptotic process, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of leukocyte tethering or rolling, neuron migration, positive regulation of T cell migration, positive regulation of axon extension involved in axon guidance, positive regulation of calcium ion import, positive regulation of cell adhesion, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of chemotaxis, positive regulation of dopamine secretion, positive regulation of endothelial cell proliferation, positive regulation of monocyte chemotaxis, positive regulation of neuron differentiation, positive regulation of vasculature development, regulation of actin polymerization or depolymerization, regulation of calcium ion transport, response to hypoxia, response to mechanical stimulus, response to peptide hormone, response to ultrasound, response to virus, signal transduction, telencephalon cell migration; MF: CXCR chemokine receptor binding, chemokine activity, chemokine receptor binding, cytokine activity, growth factor activity, integrin binding, protein binding, signaling receptor binding; CC: external side of plasma membrane, extracellular exosome, extracellular matrix, extracellular region, extracellular space
Pathways: -arrestins in gpcr desensitization, Allograft Rejection, Axon guidance, Axon guidance - Homo sapiens (human), CXCR4-mediated signaling events, Chemokine receptors bind chemokines, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Homo sapiens (human), Developmental Biology, ESR-mediated signaling, EV release from cardiac cells and their functional effects, Estrogen-dependent gene expression, G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Genes controlling nephrogenesis, HIF-1-alpha transcription factor network, Human cytomegalovirus infection - Homo sapiens (human), Intestinal immune network for IgA production - Homo sapiens (human), Leukocyte transendothelial migration - Homo sapiens (human), NF-kappa B signaling pathway - Homo sapiens (human), Neovascularisation processes, Nervous system development, Novel intracellular components of RIG-I-like receptor (RLR) pathway, Nuclear signaling by ERBB4, Pathways in cancer - Homo sapiens (human), Peptide ligand-binding receptors, Regulation of actin cytoskeleton - Homo sapiens (human), Rheumatoid arthritis - Homo sapiens (human), SARS-CoV-2 innate immunity evasion and cell-specific immune response, Signal Transduction, Signaling by ERBB4, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Syndecan-4-mediated signaling events, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human), activation of camp-dependent protein kinase pka, activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor, activation of pkc through g-protein coupled receptors, chrebp regulation by carbohydrates and camp, corticosteroids and cardioprotection, cxcr4 signaling pathway, cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway, g-protein signaling through tubby proteins, ion channels and their functional role in vascular endothelium, pertussis toxin-insensitive ccr5 signaling in macrophage, role of -arrestins in the activation and targeting of map kinases, roles of arrestin dependent recruitment of src kinases in gpcr signaling
UniProt: P48061
Entrez ID: 6387
|
Does Knockout of DDX19B in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
DDX19B
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: DDX19B (DEAD-box helicase 19B)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mRNA export from nucleus, poly(A)+ mRNA export from nucleus; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding; CC: cytoplasm, cytoplasmic stress granule, extracellular exosome, membrane, nuclear envelope, nuclear pore, nucleoplasm, nucleus
Pathways: RNA transport - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9UMR2
Entrez ID: 11269
|
Does Activation of KIAA1210 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
KIAA1210
|
protein/peptide accumulation
|
T cell
|
Gene: KIAA1210 (KIAA1210)
Type: protein-coding
Summary: Predicted to be located in acrosomal vesicle. Predicted to colocalize with basal ectoplasmic specialization. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: acrosomal vesicle, basal ectoplasmic specialization, cytoplasmic vesicle
Pathways:
UniProt: Q9ULL0
Entrez ID: 57481
|
Does Knockout of CDK12 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
CDK12
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: CDK12 (cyclin dependent kinase 12)
Type: protein-coding
Summary: Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, cellular response to estrogen stimulus, mRNA processing, negative regulation of MAPK cascade, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of stem cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of MAP kinase activity, regulation of cell cycle, transcription by RNA polymerase II; MF: ATP binding, RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cyclin K-CDK12 complex, cyclin-dependent protein kinase holoenzyme complex, cyclin/CDK positive transcription elongation factor complex, nuclear cyclin-dependent protein kinase holoenzyme complex, nuclear speck, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q9NYV4
Entrez ID: 51755
|
Does Knockout of FXR1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
FXR1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: FXR1 (FMR1 autosomal homolog 1)
Type: protein-coding
Summary: The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: animal organ development, apoptotic process, cell differentiation, cytoplasmic translational initiation, dentate gyrus development, mRNA destabilization, mRNA transport, membraneless organelle assembly, muscle organ development, muscle structure development, negative regulation of inflammatory response, negative regulation of long-term synaptic potentiation, negative regulation of mRNA catabolic process, negative regulation of translation, negative regulation of tumor necrosis factor production, nuclear pore complex assembly, nuclear pore localization, positive regulation of Rho protein signal transduction, positive regulation of long-term neuronal synaptic plasticity, positive regulation of miRNA-mediated gene silencing, positive regulation of translation, post-transcriptional regulation of gene expression, regulation of circadian sleep/wake cycle, sleep, regulation of mRNA stability, regulation of neurogenesis, regulation of synaptic transmission, glutamatergic, regulation of translation, regulation of translation at presynapse, modulating synaptic transmission, skeletal muscle organ development, spermatid development, spermatogenesis; MF: RNA binding, RNA strand annealing activity, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, mRNA binding, molecular condensate scaffold activity, nucleic acid binding, protein binding, protein heterodimerization activity, protein homodimerization activity, ribonucleoprotein complex binding, translation regulator activity; CC: axon, cell projection, costamere, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, dendrite, dendritic spine, glutamatergic synapse, intracellular membraneless organelle, membrane, neuron projection, nuclear envelope, nucleolus, nucleus, perinuclear region of cytoplasm, postsynapse, presynapse, ribonucleoprotein granule, ribosome, synapse
Pathways: Bile acids synthesis and enterohepatic circulation, RNA transport - Homo sapiens (human)
UniProt: P51114
Entrez ID: 8087
|
Does Knockout of ATP6V1B2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
ATP6V1B2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ATP6V1B2 (ATPase H+ transporting V1 subunit B2)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ATP metabolic process, monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification, vacuolar acidification; MF: ATP binding, nucleotide binding, protein binding, proton transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, extrinsic component of synaptic vesicle membrane, lysosomal membrane, melanosome, membrane, microvillus, plasma membrane, proton-transporting V-type ATPase, V1 domain, ruffle, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, mTOR signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: P21281
Entrez ID: 526
|
Does Knockout of CLEC18C in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
CLEC18C
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CLEC18C (C-type lectin domain family 18 member C)
Type: protein-coding
Summary: Enables polysaccharide binding activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and endosome. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: carbohydrate binding, polysaccharide binding; CC: Golgi apparatus, endoplasmic reticulum, endosome, extracellular region, extracellular space
Pathways:
UniProt: Q8NCF0
Entrez ID: 283971
|
Does Knockout of STX18 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
STX18
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: STX18 (syntaxin 18)
Type: protein-coding
Summary: This gene encodes a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) which is part of a membrane tethering complex that includes other SNAREs and several peripheral membrane proteins, and is involved in vesicular transport between the endoplasmic reticulum (ER) and the Golgi complex. The encoded protein is important for the organization of the smooth, rough, and exit site ER subdomains. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: endoplasmic reticulum membrane organization, intracellular protein transport, membrane fusion, positive regulation of ER to Golgi vesicle-mediated transport, positive regulation of organelle assembly, protein transport, regulation of Golgi organization, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: SNAP receptor activity, protein binding, protein domain specific binding; CC: Golgi apparatus, Golgi membrane, SNARE complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Phagosome - Homo sapiens (human), SNARE interactions in vesicular transport - Homo sapiens (human), Vesicle-mediated transport
UniProt: Q9P2W9
Entrez ID: 53407
|
Does Knockout of PCDH1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
PCDH1
|
cell proliferation
|
Cancer Cell Line
|
Gene: PCDH1 (protocadherin 1)
Type: protein-coding
Summary: This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, cell-cell signaling, homophilic cell adhesion via plasma membrane adhesion molecules, nervous system development; MF: calcium ion binding, cell adhesion molecule binding; CC: anchoring junction, cell junction, cell-cell junction, membrane, nucleolus, nucleoplasm, plasma membrane
Pathways:
UniProt: Q08174
Entrez ID: 5097
|
Does Knockout of GOLGA6C in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
GOLGA6C
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: GOLGA6C (golgin A6 family member C)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Golgi apparatus, Golgi cis cisterna, Golgi cisterna membrane, cis-Golgi network
Pathways:
UniProt: A6NDK9
Entrez ID: 653641
|
Does Knockout of KCNN4 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
KCNN4
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: KCNN4 (potassium calcium-activated channel subfamily N member 4)
Type: protein-coding
Summary: The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion transport, cell volume homeostasis, defense response, establishment of localization in cell, immune system process, macropinocytosis, monoatomic ion transmembrane transport, monoatomic ion transport, phospholipid translocation, positive regulation of T cell receptor signaling pathway, positive regulation of potassium ion transmembrane transport, positive regulation of protein secretion, potassium ion transmembrane transport, potassium ion transport, protein homotetramerization, regulation of biological quality, regulation of calcium ion import across plasma membrane, regulation of transport, saliva secretion, stabilization of membrane potential; MF: calcium-activated potassium channel activity, calmodulin binding, intermediate conductance calcium-activated potassium channel activity, potassium channel activity, protein binding, protein homodimerization activity, protein phosphatase binding, small conductance calcium-activated potassium channel activity; CC: cell projection, cytosol, membrane, neuron projection, neuronal cell body, plasma membrane, ruffle membrane, vesicle, voltage-gated potassium channel complex
Pathways: Ca2+ activated K+ channels, GnRH secretion - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Neuronal System, Potassium Channels, Protein digestion and absorption - Homo sapiens (human), Salivary secretion - Homo sapiens (human)
UniProt: O15554
Entrez ID: 3783
|
Does Knockout of EPC2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
EPC2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: EPC2 (enhancer of polycomb 2)
Type: protein-coding
Summary: Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of Piccolo NuA4 histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, regulation of transcription by RNA polymerase II; CC: NuA4 histone acetyltransferase complex, nucleosome, nucleus, piccolo histone acetyltransferase complex
Pathways:
UniProt: Q52LR7
Entrez ID: 26122
|
Does Knockout of DYNLRB1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
DYNLRB1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: DYNLRB1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: microtubule-based movement, positive regulation of intracellular transport, visual behavior; MF: dynein intermediate chain binding, identical protein binding, microtubule motor activity, protein binding; CC: centrosome, ciliary tip, cilium, cytoplasm, cytoplasmic dynein complex, cytoskeleton, dynein complex, membrane, microtubule
Pathways: 3q29 copy number variation syndrome, Ciliary landscape, Cilium Assembly, Intraflagellar transport, Intraflagellar transport proteins binding to dynein, Organelle biogenesis and maintenance, Salmonella infection - Homo sapiens (human), TGF-beta receptor signaling, TGF_beta_Receptor
UniProt: Q9NP97
Entrez ID: 83658
|
Does Knockout of NPR2 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
NPR2
|
response to virus
|
Lung Cancer Cell Line
|
Gene: NPR2 (natriuretic peptide receptor 2)
Type: protein-coding
Summary: This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, activation of meiosis involved in egg activation, axonogenesis, axonogenesis involved in innervation, blood circulation, blood vessel development, blood vessel remodeling, bone development, bone growth, c-di-GMP signaling, cGMP biosynthetic process, cGMP metabolic process, cartilage development, cellular response to cGMP, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to peptide, chemical synaptic transmission, chondrocyte differentiation, chondrocyte proliferation, chromosome organization, collateral sprouting, cumulus cell differentiation, cyclic nucleotide biosynthetic process, digestive tract development, digestive tract morphogenesis, endochondral ossification, epidermal growth factor receptor signaling pathway, execution phase of apoptosis, female genitalia development, gastric emptying, genitalia morphogenesis, germ cell development, growth plate cartilage development, intracellular signal transduction, limb development, limb morphogenesis, lymph vessel development, meiotic cell cycle, meiotic cell cycle process involved in oocyte maturation, multicellular organism growth, negative regulation of meiotic cell cycle, negative regulation of oocyte maturation, nerve development, neuron apoptotic process, neuronal action potential, oocyte development, ossification, ovarian follicle development, post-anal tail morphogenesis, receptor guanylyl cyclase signaling pathway, regulation of blood pressure, response to fibroblast growth factor, response to hormone, response to luteinizing hormone, response to salt, response to wounding, sensory perception of sound, single fertilization, smooth muscle tissue development, spermatogenesis, startle response, vacuole organization, vascular wound healing, vasculogenesis, vestibulocochlear nerve development, vestibulocochlear nerve maturation, white fat cell differentiation; MF: ATP binding, GTP binding, guanylate cyclase activity, hormone binding, identical protein binding, lyase activity, natriuretic peptide receptor activity, nucleotide binding, peptide hormone binding, phosphorus-oxygen lyase activity, protein binding, protein kinase activity; CC: cilium, cytoplasm, membrane, neuron projection, nucleus, plasma membrane, synapse
Pathways: Cardiac conduction, FGFR3 signaling in chondrocyte proliferation and terminal differentiation, Muscle contraction, Oxytocin signaling pathway - Homo sapiens (human), Physiological factors, Purine metabolism - Homo sapiens (human), Vascular smooth muscle contraction - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P20594
Entrez ID: 4882
|
Does Knockout of MRPS17 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
MRPS17
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: MRPS17 (mitochondrial ribosomal protein S17)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9Y2R5
Entrez ID: 51373
|
Does Knockout of ILDR1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
ILDR1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: ILDR1 (immunoglobulin like domain containing receptor 1)
Type: protein-coding
Summary: This gene encodes a protein that contains an immunoglobulin-like domain. The encoded protein may function as a multimeric receptor at the cell surface. The expression of this gene may be a diagnostic marker for cancer progression. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, epithelial structure maintenance, establishment of localization in cell, peptide hormone secretion, positive regulation of peptide hormone secretion, protein localization to tricellular tight junction, regulation of RNA splicing, response to fatty acid, tricellular tight junction assembly, vesicle-mediated transport; MF: high-density lipoprotein particle receptor activity, identical protein binding, protein binding; CC: anchoring junction, bicellular tight junction, cytoplasm, cytosol, membrane, plasma membrane, protein-containing complex, tight junction, tricellular tight junction
Pathways:
UniProt: Q86SU0
Entrez ID: 286676
|
Does Knockout of IDUA in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
IDUA
|
response to virus
|
Hepatoma Cell Line
|
Gene: IDUA (alpha-L-iduronidase)
Type: protein-coding
Summary: This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate metabolic process, dermatan sulfate proteoglycan catabolic process, disaccharide metabolic process, glycosaminoglycan catabolic process, heparan sulfate proteoglycan catabolic process, heparin proteoglycan catabolic process; MF: L-iduronidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, signaling receptor binding; CC: extracellular exosome, lysosomal lumen, lysosome
Pathways: CS/DS degradation, Chondroitin sulfate/dermatan sulfate metabolism, Disease, Diseases of carbohydrate metabolism, Diseases of metabolism, Glycosaminoglycan degradation, Glycosaminoglycan degradation - Homo sapiens (human), Glycosaminoglycan metabolism, HS-GAG degradation, Heparan sulfate/heparin (HS-GAG) metabolism, Lysosome - Homo sapiens (human), MPS I - Hurler syndrome (CS/DS degradation), MPS I - Hurler syndrome (HS-GAG degradation), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Mucopolysaccharidoses, dermatan sulfate degradation (metazoa)
UniProt: P35475
Entrez ID: 3425
|
Does Knockout of CKLF in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
CKLF
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: CKLF (chemokine like factor)
Type: protein-coding
Summary: The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011].
Gene Ontology: BP: chemotaxis, leukocyte chemotaxis, lymphocyte chemotaxis, macrophage chemotaxis, neutrophil chemotaxis, secretion by cell, signal transduction; MF: chemokine activity, cytokine activity, protein binding; CC: extracellular region, extracellular space, membrane
Pathways:
UniProt: Q9UBR5
Entrez ID: 51192
|
Does Knockout of HRNR in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
HRNR
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: HRNR (hornerin)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity and transition metal ion binding activity. Involved in cell envelope organization and establishment of skin barrier. Located in cornified envelope; keratohyalin granule; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell envelope organization, establishment of skin barrier, keratinization; MF: calcium ion binding, metal ion binding, transition metal ion binding; CC: azurophil granule lumen, cornified envelope, cytoplasm, extracellular exosome, extracellular matrix, extracellular region, keratohyalin granule, nucleus, perinuclear region of cytoplasm
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q86YZ3
Entrez ID: 388697
|
Does Knockout of EIF2B4 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
EIF2B4
|
cell proliferation
|
Bladder Carcinoma
|
Gene: EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)
Type: protein-coding
Summary: Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell receptor signaling pathway, animal organ development, central nervous system development, cytoplasmic translational initiation, myelination, oligodendrocyte development, ovarian follicle development, regulation of translation, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, protein binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Translation, Translation Factors
UniProt: Q9UI10
Entrez ID: 8890
|
Does Knockout of TUBGCP3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
TUBGCP3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: TUBGCP3 (tubulin gamma complex component 3)
Type: protein-coding
Summary: Enables gamma-tubulin binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Located in cytoplasm and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, single fertilization, spindle assembly; MF: gamma-tubulin binding, microtubule minus-end binding, protein binding, structural constituent of cytoskeleton, structural molecule activity; CC: centriole, centrosome, cytoplasm, cytoskeleton, cytosol, gamma-tubulin complex, membrane, microtubule, microtubule organizing center, polar microtubule, spindle, spindle pole
Pathways: 15q11.2 copy number variation syndrome, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes
UniProt: Q96CW5
Entrez ID: 10426
|
Does Knockout of PRKACA in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
PRKACA
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PRKACA (protein kinase cAMP-activated catalytic subunit alpha)
Type: protein-coding
Summary: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: TORC1 signaling, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cAMP/PKA signal transduction, cell communication by electrical coupling involved in cardiac conduction, cellular response to cold, cellular response to epinephrine stimulus, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to heat, cellular response to nutrient levels, cellular response to parathyroid hormone stimulus, cytokine-mediated signaling pathway, high-density lipoprotein particle assembly, interleukin-2-mediated signaling pathway, intracellular potassium ion homeostasis, mRNA processing, mesoderm formation, mitochondrial protein catabolic process, modulation of chemical synaptic transmission, negative regulation of TORC1 signaling, negative regulation of glycolytic process through fructose-6-phosphate, negative regulation of interleukin-2 production, negative regulation of smoothened signaling pathway, neural tube closure, peptidyl-serine phosphorylation, positive regulation of calcium-mediated signaling, positive regulation of cholesterol biosynthetic process, positive regulation of gluconeogenesis, positive regulation of insulin secretion, positive regulation of phagocytosis, positive regulation of protein export from nucleus, postsynaptic modulation of chemical synaptic transmission, proteasome-mediated ubiquitin-dependent protein catabolic process, protein export from nucleus, protein localization to lipid droplet, protein phosphorylation, regulation of bicellular tight junction assembly, regulation of cardiac conduction, regulation of cardiac muscle contraction, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of cell cycle, regulation of heart rate, regulation of macroautophagy, regulation of osteoblast differentiation, regulation of proteasomal protein catabolic process, regulation of protein processing, renal water homeostasis, sperm capacitation, vascular endothelial cell response to laminar fluid shear stress; MF: ATP binding, cAMP-dependent protein kinase activity, channel activator activity, kinase activity, magnesium ion binding, manganese ion binding, nucleotide binding, protein binding, protein domain specific binding, protein kinase A regulatory subunit binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, transferase activity, ubiquitin protein ligase binding; CC: acrosomal vesicle, axoneme, cAMP-dependent protein kinase complex, calcium channel complex, cell projection, centrosome, ciliary base, cilium, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, glutamatergic synapse, membrane, mitochondrial matrix, mitochondrion, motile cilium, neuromuscular junction, nuclear speck, nucleoplasm, nucleotide-activated protein kinase complex, nucleus, perinuclear region of cytoplasm, plasma membrane, plasma membrane raft, postsynapse, sperm flagellum, sperm midpiece
Pathways: ADORA2B mediated anti-inflammatory cytokines production, AURKA Activation by TPX2, Acebutolol Action Pathway, Activation of NMDA receptors and postsynaptic events, Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alcoholism - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Alpha4 beta1 integrin signaling events, Alprenolol Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Amoebiasis - Homo sapiens (human), Amphetamine addiction - Homo sapiens (human), Anchoring of the basal body to the plasma membrane, Anti-inflammatory response favouring Leishmania parasite infection, Apelin signaling pathway - Homo sapiens (human), Aquaporin-mediated transport, Arbutamine Action Pathway, Atenolol Action Pathway, Aurora A signaling, Autophagy - animal - Homo sapiens (human), Axon guidance, Betaxolol Action Pathway, Bevantolol Action Pathway, Bile secretion - Homo sapiens (human), Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupranolol Action Pathway, C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, CREB1 phosphorylation through the activation of Adenylate Cyclase, Ca-dependent events, CaM pathway, Calcium Regulation in the Cardiac Cell, Calcium signaling in the CD4+ TCR pathway, Calcium signaling pathway - Homo sapiens (human), Calmodulin induced events, Cannabinoid receptor signaling, Cardiac conduction, Carteolol Action Pathway, Carvedilol Action Pathway, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Centrosome maturation, Chemokine signaling pathway - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Cilium Assembly, Circadian entrainment - Homo sapiens (human), Class I PI3K signaling events mediated by Akt, Cocaine addiction - Homo sapiens (human), Common Pathways Underlying Drug Addiction, Complement system, Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Cytokine Signaling in Immune system, DAG and IP3 signaling, DARPP-32 events, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Developmental Biology, Dilated cardiomyopathy - Homo sapiens (human), Diltiazem Action Pathway, Disease, Disopyramide Action Pathway, Disorders of Developmental Biology, Disorders of Nervous System Development, Dobutamine Action Pathway, Dopamine metabolism, Dopaminergic synapse - Homo sapiens (human), Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), Epinephrine Action Pathway, ErbB2/ErbB3 signaling events, Esmolol Action Pathway, Estrogen signaling pathway, Estrogen signaling pathway - Homo sapiens (human), FCGR3A-mediated IL10 synthesis, Factors involved in megakaryocyte development and platelet production, Felodipine Action Pathway, Flecainide Action Pathway, Follicle Stimulating Hormone (FSH) signaling pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, Fragile X Syndrome, G Protein Signaling Pathways, G alpha (i) signalling events, G alpha (s) signalling events, G-protein mediated events, G2/M Transition, GABAergic synapse - Homo sapiens (human), GLI3 is processed to GLI3R by the proteasome, GMCSF-mediated signaling events, GPCR downstream signalling, GPER1 signaling, Gap junction - Homo sapiens (human), Gastric acid secretion - Homo sapiens (human), Gastrin signaling pathway, Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling in metabolic regulation, Glucagon signaling pathway - Homo sapiens (human), Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucocorticoid receptor regulatory network, Glucose metabolism, Glutamatergic synapse - Homo sapiens (human), Glycolysis, GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), HDL assembly, Hedgehog, Hedgehog 'off' state, Hedgehog Signaling Pathway, Hedgehog signaling events mediated by Gli proteins, Hedgehog signaling pathway - Homo sapiens (human), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Hippo-Merlin Signaling Dysregulation, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IL-3 signaling pathway, IL3, IL3-mediated signaling events, Ibutilide Action Pathway, Immune System, Infectious disease, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Innate Immune System, Insulin secretion - Homo sapiens (human), Insulin signaling pathway - Homo sapiens (human), Integration of energy metabolism, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, Ion homeostasis, Isoprenaline Action Pathway, Isradipine Action Pathway, LKB1 signaling events, LPA4-mediated signaling events, Labetalol Action Pathway, Leishmania infection, Leishmania parasite growth and survival, Levobunolol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, Lipid Metabolism Pathway, Long-term potentiation - Homo sapiens (human), Longevity regulating pathway - Homo sapiens (human), Longevity regulating pathway - multiple species - Homo sapiens (human), Loss of Nlp from mitotic centrosomes, Loss of function of MECP2 in Rett syndrome, Loss of phosphorylation of MECP2 at T308, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK6/MAPK4 signaling, Melanogenesis - Homo sapiens (human), Mesodermal commitment pathway, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of lipids, Metabolism of proteins, Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Mitochondrial protein degradation, Mitotic G2-G2/M phases, Mitotic Prometaphase, Morphine addiction - Homo sapiens (human), Muscle contraction, Muscle/Heart Contraction, Myometrial relaxation and contraction pathways, Nadolol Action Pathway, Nebivolol Action Pathway, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine Activity on Dopaminergic Neurons, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Olfactory transduction - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Opioid Signalling, Organelle biogenesis and maintenance, Ovarian steroidogenesis - Homo sapiens (human), Oxprenolol Action Pathway, Oxytocin signaling pathway - Homo sapiens (human), PKA activation, PKA activation in glucagon signalling, PKA-mediated phosphorylation of CREB, PKA-mediated phosphorylation of key metabolic factors, PLC beta mediated events, Parasitic Infection Pathways, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways Regulating Hippo Signaling, Pathways in cancer - Homo sapiens (human), Penbutolol Action Pathway, Pervasive developmental disorders, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Platelet activation - Homo sapiens (human), Post NMDA receptor activation events, Practolol Action Pathway, Prion disease - Homo sapiens (human), Procainamide (Antiarrhythmic) Action Pathway, Progesterone-mediated oocyte maturation - Homo sapiens (human), Propranolol Action Pathway, Proteoglycans in cancer - Homo sapiens (human), Quinidine Action Pathway, RET signaling, RNA Polymerase II Transcription, ROBO receptors bind AKAP5, Rap1 signalling, Ras signaling, Ras signaling pathway - Homo sapiens (human), Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of MECP2 expression and activity, Regulation of Microtubule Cytoskeleton, Regulation of PLK1 Activity at G2/M Transition, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism, Regulation of insulin secretion, Regulation of lipolysis in adipocytes - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Renin secretion - Homo sapiens (human), Response of endothelial cells to shear stress, Retinoic acid receptors-mediated signaling, Retrograde endocannabinoid signaling - Homo sapiens (human), Role of Calcineurin-dependent NFAT signaling in lymphocytes, SHP2 signaling, Salivary secretion - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Signaling by Hedgehog, Signaling by Interleukins, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Signaling events mediated by HDAC Class I, Signaling events mediated by VEGFR1 and VEGFR2, Signaling events regulated by Ret tyrosine kinase, Sotalol Action Pathway, Sterol regulatory element-binding proteins (SREBP) signaling, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Syndecan-1-mediated signaling events, Syndecan-2-mediated signaling events, Taste transduction - Homo sapiens (human), Thermogenesis, Thermogenesis - Homo sapiens (human), Thromboxane A2 receptor signaling, Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid hormone synthesis - Homo sapiens (human), Tight junction - Homo sapiens (human), Timolol Action Pathway, Tocainide Action Pathway, Transcriptional Regulation by MECP2, Translation inhibitors in chronically activated PDGFRA cells, Transmission across Chemical Synapses, Transport of small molecules, Triglyceride catabolism, Triglyceride metabolism, VEGFA-VEGFR2 Pathway, VEGFR1 specific signals, Vascular smooth muscle contraction - Homo sapiens (human), Vasopressin regulates renal water homeostasis via Aquaporins, Vasopressin-regulated water reabsorption - Homo sapiens (human), Verapamil Action Pathway, Vibrio cholerae infection - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), Wnt signaling pathway - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human)
UniProt: P17612
Entrez ID: 5566
|
Does Knockout of DDX23 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
DDX23
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DDX23 (DEAD-box helicase 23)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: R-loop processing, RNA splicing, RNA splicing, via transesterification reactions, cis assembly of pre-catalytic spliceosome, mRNA processing, mRNA splicing, via spliceosome; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding; CC: U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, chromatin, chromosome, extracellular exosome, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q9BUQ8
Entrez ID: 9416
|
Does Inhibition of CHAF1A in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
CHAF1A
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CHAF1A (chromatin assembly factor 1 subunit A)
Type: protein-coding
Summary: Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin assembly, chromatin organization, nucleosome assembly; MF: chromatin binding, chromo shadow domain binding, identical protein binding, protein binding, unfolded protein binding; CC: CAF-1 complex, chromatin, nucleus, protein-containing complex
Pathways: Nanoparticle triggered autophagic cell death, btg family proteins and cell cycle regulation
UniProt: Q13111
Entrez ID: 10036
|
Does Knockout of LHB in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
LHB
|
cell proliferation
|
Cancer Cell Line
|
Gene: LHB (luteinizing hormone subunit beta)
Type: protein-coding
Summary: This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell-cell signaling, hormone-mediated signaling pathway, male gonad development, progesterone biosynthetic process, signal transduction; MF: hormone activity, protein binding, signaling receptor binding; CC: Golgi lumen, cytoplasm, extracellular region, extracellular space, pituitary gonadotropin complex
Pathways: Androgen biosynthesis, Asparagine N-linked glycosylation, Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Glycoprotein hormones, GnRH secretion - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Hormone ligand-binding receptors, Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroid hormones, Metabolism of steroids, Mineralocorticoid biosynthesis, N-glycan antennae elongation in the medial/trans-Golgi, Neuroactive ligand-receptor interaction - Homo sapiens (human), Ovarian steroidogenesis - Homo sapiens (human), Peptide hormone biosynthesis, Peptide hormone metabolism, Post-translational protein modification, Prolactin signaling pathway - Homo sapiens (human), Reactions specific to the complex N-glycan synthesis pathway, Signal Transduction, Signaling by GPCR, Transport to the Golgi and subsequent modification, cAMP signaling pathway - Homo sapiens (human)
UniProt: P01229
Entrez ID: 3972
|
Does Knockout of ZNF710 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
ZNF710
|
cell proliferation
|
Cancer Cell Line
|
Gene: ZNF710 (zinc finger protein 710)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q8N1W2
Entrez ID: 374655
|
Does Knockout of DCUN1D5 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
DCUN1D5
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DCUN1D5 (defective in cullin neddylation 1 domain containing 5)
Type: protein-coding
Summary: Enables cullin family protein binding activity. Involved in cellular response to DNA damage stimulus; positive regulation of protein neddylation; and regulation of cell growth. Located in nucleus and spindle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, positive regulation of protein neddylation, protein neddylation, regulation of cell growth, regulation of protein neddylation; MF: cullin family protein binding, protein binding, ubiquitin conjugating enzyme binding, ubiquitin-like protein binding; CC: cytoplasm, cytoskeleton, nucleus, spindle, ubiquitin ligase complex
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9BTE7
Entrez ID: 84259
|
Does Knockout of RPL9 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
RPL9
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RPL9 (ribosomal protein L9)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, focal adhesion, membrane, nucleus, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P32969
Entrez ID: 6133
|
Does Knockout of RAB18 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
RAB18
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: RAB18 (RAB18, member RAS oncogene family)
Type: protein-coding
Summary: The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: brain development, endoplasmic reticulum tubular network organization, eye development, intracellular protein transport, lipid droplet organization, protein transport, small GTPase-mediated signal transduction; MF: GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding; CC: Golgi apparatus, apical plasma membrane, cis-Golgi network membrane, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, lipid droplet, membrane, plasma membrane, secretory granule membrane
Pathways: COPI-independent Golgi-to-ER retrograde traffic, Golgi-to-ER retrograde transport, Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q9NP72
Entrez ID: 22931
|
Does Knockout of NLRP4 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
NLRP4
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: NLRP4 (NLR family pyrin domain containing 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016].
Gene Ontology: BP: antiviral innate immune response, inflammatory response, negative regulation of innate immune response, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K33-linked deubiquitination, protein K48-linked ubiquitination, regulation of inflammatory response; MF: ATP binding, molecular adaptor activity, nucleotide binding; CC: cytoplasm, cytosol
Pathways: Cytosolic sensors of pathogen-associated DNA , IRF3 mediated activation of type 1 IFN, IRF3-mediated induction of type I IFN, Immune System, Innate Immune System, Nucleotide-binding Oligomerization Domain (NOD) pathway, Pathogenic Escherichia coli infection - Homo sapiens (human), Regulation of innate immune responses to cytosolic DNA, STING mediated induction of host immune responses, TNFalpha, ZBP1(DAI) mediated induction of type I IFNs
UniProt: Q96MN2
Entrez ID: 147945
|
Does Knockout of RGS7BP in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
RGS7BP
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RGS7BP (regulator of G protein signaling 7 binding protein)
Type: protein-coding
Summary: This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, negative regulation of signal transduction, regulation of postsynaptic membrane potential; CC: axon, cytoplasm, dendritic shaft, dendritic spine head, glutamatergic synapse, membrane, neuron projection, nucleus, perikaryon, plasma membrane, postsynapse, postsynaptic density membrane, presynapse, presynaptic membrane
Pathways:
UniProt: Q6MZT1
Entrez ID: 401190
|
Does Knockout of ISCU in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
ISCU
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ISCU (iron-sulfur cluster assembly enzyme)
Type: protein-coding
Summary: This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: [2Fe-2S] cluster assembly, [4Fe-4S] cluster assembly, intracellular iron ion homeostasis, iron-sulfur cluster assembly, negative regulation of iron ion import across plasma membrane, positive regulation of mitochondrial electron transport, NADH to ubiquinone; MF: 2 iron, 2 sulfur cluster binding, ferrous iron binding, iron ion binding, iron-sulfur cluster binding, iron-sulfur cluster chaperone activity, metal ion binding, molecular adaptor activity, protein binding, protein homodimerization activity, zinc ion binding; CC: cytoplasm, cytosol, iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrial matrix, mitochondrion, nucleus
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Complex III assembly, Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Respiratory electron transport
UniProt: Q9H1K1
Entrez ID: 23479
|
Does Knockout of TRMT5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
TRMT5
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: TRMT5 (tRNA methyltransferase 5)
Type: protein-coding
Summary: tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: methylation, mitochondrial tRNA methylation, tRNA N1-guanine methylation, tRNA methylation, tRNA processing; MF: methyltransferase activity, tRNA (guanine(37)-N1)-methyltransferase activity, tRNA methyltransferase activity, transferase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion, nucleus
Pathways: Metabolism of RNA, Synthesis of wybutosine at G37 of tRNA(Phe), tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q32P41
Entrez ID: 57570
|
Does Knockout of MIR587 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
MIR587
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: MIR587 (microRNA 587)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 693172
|
Does Knockout of HEY2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
HEY2
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: HEY2 (hes related family bHLH transcription factor with YRPW motif 2)
Type: protein-coding
Summary: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Notch signaling pathway, anatomical structure morphogenesis, anterior/posterior axis specification, anterior/posterior pattern specification, aortic valve morphogenesis, arterial endothelial cell differentiation, artery development, ascending aorta morphogenesis, atrial septum morphogenesis, atrioventricular valve development, blood vessel development, blood vessel endothelial cell differentiation, cardiac conduction system development, cardiac epithelial to mesenchymal transition, cardiac left ventricle morphogenesis, cardiac muscle cell apoptotic process, cardiac muscle cell proliferation, cardiac muscle hypertrophy, cardiac muscle hypertrophy in response to stress, cardiac right ventricle morphogenesis, cardiac septum morphogenesis, cardiac vascular smooth muscle cell development, cardiac ventricle morphogenesis, cell fate commitment, circulatory system development, cochlea development, coronary vasculature morphogenesis, dorsal aorta morphogenesis, endocardial cushion to mesenchymal transition involved in heart valve formation, epithelial to mesenchymal transition involved in endocardial cushion formation, heart development, heart trabecula formation, labyrinthine layer blood vessel development, mesenchymal cell development, muscular septum morphogenesis, negative regulation of DNA-templated transcription, negative regulation of Notch signaling pathway, negative regulation of biomineral tissue development, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cardiac vascular smooth muscle cell differentiation, negative regulation of gene expression, negative regulation of smooth muscle cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription initiation by RNA polymerase II, outflow tract morphogenesis, pattern specification process, positive regulation of cardiac muscle cell proliferation, positive regulation of heart rate, positive regulation of transcription by RNA polymerase II, protein-DNA complex assembly, pulmonary artery morphogenesis, pulmonary valve morphogenesis, regulation of DNA-templated transcription, regulation of gene expression, regulation of inner ear auditory receptor cell differentiation, regulation of neurogenesis, regulation of transcription by RNA polymerase II, regulation of vasculogenesis, smooth muscle cell differentiation, tricuspid valve formation, tricuspid valve morphogenesis, umbilical cord morphogenesis, vascular associated smooth muscle cell development, vasculogenesis, ventricular cardiac muscle cell development, ventricular septum morphogenesis, ventricular trabecula myocardium morphogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cis-regulatory region sequence-specific DNA binding, histone deacetylase binding, identical protein binding, protein binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus, transcription repressor complex
Pathways: Breast cancer - Homo sapiens (human), Breast cancer pathway, Cardiogenesis, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Gene expression (Transcription), Generic Transcription Pathway, Heart Development, Human papillomavirus infection - Homo sapiens (human), NOTCH1 Intracellular Domain Regulates Transcription, NOTCH3 Intracellular Domain Regulates Transcription, NOTCH4 Intracellular Domain Regulates Transcription, Neural Crest Differentiation, Notch Signaling Pathway Netpath, Notch signaling pathway - Homo sapiens (human), Notch-mediated HES/HEY network, Osteoblast differentiation, Pathways in cancer - Homo sapiens (human), RNA Polymerase II Transcription, RUNX2 regulates bone development, RUNX2 regulates osteoblast differentiation, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH3, Signaling by NOTCH4, Transcriptional regulation by RUNX2, p73 transcription factor network, segmentation clock
UniProt: Q9UBP5
Entrez ID: 23493
|
Does Knockout of MTERF4 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
MTERF4
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: MTERF4 (mitochondrial transcription termination factor 4)
Type: protein-coding
Summary: Enables rRNA binding activity. Predicted to be involved in rRNA processing and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including mitochondrial transcription; protein targeting to mitochondrion; and ribosome assembly. Located in cytosol and mitochondrion. Part of mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: camera-type eye development, heart development, mitochondrial ribosome assembly, mitochondrial transcription, protein targeting to mitochondrion, rRNA processing, regulation of mitochondrial transcription, ribosome assembly; MF: RNA binding, nucleic acid binding, protein binding, rRNA binding; CC: cytosol, mitochondrial matrix, mitochondrion
Pathways: Metabolism of RNA, rRNA modification in the mitochondrion, rRNA processing, rRNA processing in the mitochondrion
UniProt: Q7Z6M4
Entrez ID: 130916
|
Does Knockout of PRKRIP1 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
PRKRIP1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: PRKRIP1 (PRKR interacting protein 1)
Type: protein-coding
Summary: Predicted to enable double-stranded RNA binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Involved in renal system process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, renal system process; MF: double-stranded RNA binding, protein binding, protein kinase binding, protein kinase inhibitor activity; CC: extracellular exosome, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9H875
Entrez ID: 79706
|
Does Knockout of CPE in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
CPE
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CPE (carboxypeptidase E)
Type: protein-coding
Summary: This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: Wnt signaling pathway, cardiac left ventricle morphogenesis, cell communication, insulin processing, intracellular protein localization, neuropeptide signaling pathway, peptide hormone secretion, peptide metabolic process, protein localization to membrane, protein localization to secretory granule, protein modification process, protein processing, proteolysis, signaling; MF: carboxypeptidase activity, cell adhesion molecule binding, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, neurexin family protein binding, peptidase activity, protein binding, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytoplasmic vesicle, endomembrane system, extracellular exosome, extracellular region, extracellular space, membrane, plasma membrane, secretory granule, secretory granule membrane, transport vesicle, transport vesicle membrane
Pathways: Arf6 trafficking events, Insulin processing, Metabolism of proteins, Peptide hormone metabolism, Type I diabetes mellitus - Homo sapiens (human)
UniProt: P16870
Entrez ID: 1363
|
Does Knockout of PAQR8 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
PAQR8
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: PAQR8 (progestin and adipoQ receptor family member 8)
Type: protein-coding
Summary: Predicted to enable steroid binding activity and steroid hormone receptor activity. Predicted to be involved in response to steroid hormone. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, nuclear receptor-mediated steroid hormone signaling pathway, oogenesis, response to steroid hormone; MF: lipid binding, nuclear steroid receptor activity, protein binding, steroid binding; CC: Golgi apparatus, membrane, plasma membrane
Pathways:
UniProt: Q8TEZ7
Entrez ID: 85315
|
Does Knockout of NDUFAF5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
NDUFAF5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: NDUFAF5 (NADH:ubiquinone oxidoreductase complex assembly factor 5)
Type: protein-coding
Summary: The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes a mitochondrial protein that is associated with the matrix face of the mitochondrial inner membrane and is required for complex I assembly. A mutation in this gene results in mitochondrial complex I deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: methylation, mitochondrial respiratory chain complex I assembly; MF: S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, monooxygenase activity, oxidoreductase activity, protein binding, transferase activity; CC: matrix side of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: Q5TEU4
Entrez ID: 79133
|
Does Knockout of ELOA in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
ELOA
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ELOA (elongin A)
Type: protein-coding
Summary: This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter; CC: elongin complex, extracellular space, nucleoplasm, nucleus, site of DNA damage
Pathways: Disease, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV elongation arrest and recovery, Infectious disease, Late Phase of HIV Life Cycle, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcriptional Regulation by TP53, VEGFA-VEGFR2 Signaling Pathway, Viral Infection Pathways
UniProt: Q14241
Entrez ID: 6924
|
Does Knockout of GRM2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
GRM2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: GRM2 (glutamate metabotropic receptor 2)
Type: protein-coding
Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: G protein-coupled glutamate receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, behavioral response to nicotine, cellular response to stress, chemical synaptic transmission, gene expression, glutamate receptor signaling pathway, glutamate secretion, intracellular glutamate homeostasis, long-term synaptic depression, negative regulation of adenylate cyclase activity, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, presynaptic modulation of chemical synaptic transmission, regulation of dopamine secretion, regulation of glutamate secretion, regulation of response to drug, regulation of synaptic transmission, glutamatergic, response to cocaine, signal transduction; MF: G protein-coupled receptor activity, calcium channel regulator activity, glutamate receptor activity, group II metabotropic glutamate receptor activity, protein binding, scaffold protein binding; CC: astrocyte projection, axon, cell projection, dendrite, glutamatergic synapse, membrane, neuron projection, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), Cocaine addiction - Homo sapiens (human), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class C Metabotropic glutamate, pheromone, Glutamatergic synapse - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q14416
Entrez ID: 2912
|
Does Knockout of CDC20 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
CDC20
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CDC20 (cell division cycle 20)
Type: protein-coding
Summary: CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, anaphase-promoting complex-dependent catabolic process, cell differentiation, cell division, metaphase/anaphase transition of cell cycle, metaphase/anaphase transition of meiosis I, mitotic sister chromatid cohesion, mitotic spindle assembly, mitotic spindle assembly checkpoint signaling, nervous system development, positive regulation of anaphase-promoting complex-dependent catabolic process, positive regulation of cell population proliferation, positive regulation of mitotic metaphase/anaphase transition, positive regulation of synapse maturation, positive regulation of synaptic plasticity, positive regulation of ubiquitin protein ligase activity, protein deubiquitination, protein ubiquitination, regulation of dendrite development, regulation of meiotic cell cycle, regulation of meiotic nuclear division, regulation of mitotic cell cycle; MF: anaphase-promoting complex binding, histone deacetylase binding, protein binding, ubiquitin ligase activator activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activator activity; CC: anaphase-promoting complex, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, mitotic checkpoint complex, nucleoplasm, perinuclear region of cytoplasm, protein-containing complex, spindle, spindle pole
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Antigen processing: Ubiquitination & Proteasome degradation, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Deubiquitination, EML4 and NUDC in mitotic spindle formation, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), PLK1 signaling events, Phosphorylation of Emi1, Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, Regulation of sister chromatid separation at the metaphase-anaphase transition, Resolution of Sister Chromatid Cohesion, SCF-beta-TrCP mediated degradation of Emi1, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human)
UniProt: Q12834
Entrez ID: 991
|
Does Knockout of VCPKMT in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
VCPKMT
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: VCPKMT (valosin containing protein lysine methyltransferase)
Type: protein-coding
Summary: Enables ATPase binding activity and protein-lysine N-methyltransferase activity. Involved in negative regulation of ATPase activity and peptidyl-lysine trimethylation. Located in cytosol. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: methylation, negative regulation of ATP-dependent activity, peptidyl-lysine methylation, peptidyl-lysine trimethylation; MF: ATPase binding, methyltransferase activity, protein binding, protein methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Protein methylation
UniProt: Q9H867
Entrez ID: 79609
|
Does Knockout of MRPS10 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
MRPS10
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MRPS10 (mitochondrial ribosomal protein S10)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: P82664
Entrez ID: 55173
|
Does Activation of SEC14L6 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
SEC14L6
|
response to virus
|
Hepatoma Cell Line
|
Gene: SEC14L6 (SEC14 like lipid binding 6)
Type: protein-coding
Summary: Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: B5MCN3
Entrez ID: 730005
|
Does Knockout of INTS4 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
INTS4
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: INTS4 (integrator complex subunit 4)
Type: protein-coding
Summary: INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, regulation of transcription elongation by RNA polymerase II, snRNA processing; MF: protein binding, protein-macromolecule adaptor activity; CC: INTAC complex, cytoplasm, integrator complex, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q96HW7
Entrez ID: 92105
|
Does Knockout of ATP6V0D2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
ATP6V0D2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ATP6V0D2 (ATPase H+ transporting V0 subunit d2)
Type: protein-coding
Summary: Predicted to enable proton transmembrane transporter activity. Predicted to be involved in vacuolar acidification and vacuolar transport. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, vacuolar acidification, vacuolar transport; MF: protein binding, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, early endosome, endosome, endosome membrane, extracellular exosome, lysosomal membrane, membrane, phagocytic vesicle membrane, plasma membrane proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V0 domain, vacuolar proton-transporting V-type ATPase complex
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Homo sapiens (human), Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Homo sapiens (human), Vibrio cholerae infection - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human)
UniProt: Q8N8Y2
Entrez ID: 245972
|
Does Knockout of GPATCH3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
GPATCH3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GPATCH3 (G-patch domain containing 3)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and positive regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, positive regulation of DNA-templated transcription; MF: nucleic acid binding, protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q96I76
Entrez ID: 63906
|
Does Knockout of GGCX in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
GGCX
|
response to chemicals
|
Melanoma Cell Line
|
Gene: GGCX (gamma-glutamyl carboxylase)
Type: protein-coding
Summary: This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: blood coagulation, negative regulation of bone development, negative regulation of neurotransmitter secretion, negative regulation of testosterone biosynthetic process, protein maturation, protein modification process, vitamin K metabolic process; MF: gamma-glutamyl carboxylase activity, lyase activity, vitamin binding; CC: endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, membrane
Pathways: Acenocoumarol Action Pathway, Alteplase Action Pathway, Aminocaproic Acid Action Pathway, Anistreplase Action Pathway, Aprotinin Action Pathway, Ardeparin Action Pathway, Argatroban Action Pathway, Bivalirudin Action Pathway, Coagulation , Defective factor IX causes hemophilia B, Defective gamma-carboxylation of F9, Defects of contact activation system (CAS) and kallikrein/kinin system (KKS), Dicoumarol Action Pathway, Dicumarol Action Pathway, Disease, Diseases of hemostasis, Enoxaparin Action Pathway, Fondaparinux Action Pathway, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Gamma-carboxylation of protein precursors, Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Heparin Action Pathway, Lepirudin Action Pathway, Metabolism of proteins, Phenindione Action Pathway, Phenprocoumon Action Pathway, Post-translational protein modification, Reteplase Action Pathway, Streptokinase Action Pathway, Tenecteplase Action Pathway, Tranexamic Acid Action Pathway, Ubiquinone and other terpenoid-quinone biosynthesis - Homo sapiens (human), Urokinase Action Pathway, Vitamin K Metabolism, Warfarin Action Pathway, Ximelagatran Action Pathway
UniProt: P38435
Entrez ID: 2677
|
Does Knockout of TM7SF3 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
TM7SF3
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: TM7SF3 (transmembrane 7 superfamily member 3)
Type: protein-coding
Summary: Involved in cellular response to unfolded protein; negative regulation of programmed cell death; and positive regulation of insulin secretion. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to unfolded protein, negative regulation of programmed cell death, positive regulation of insulin secretion; CC: extracellular exosome, membrane, plasma membrane
Pathways: Genotoxicity pathway
UniProt: Q9NS93
Entrez ID: 51768
|
Does Knockout of RMND1 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
RMND1
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: RMND1 (required for meiotic nuclear division 1 homolog)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the evolutionary conserved sif2 family of proteins that share the DUF155 domain in common. This protein is thought to be localized in the mitochondria and involved in mitochondrial translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-11. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: positive regulation of mitochondrial translation, translation; CC: mitochondrion
Pathways:
UniProt: Q9NWS8
Entrez ID: 55005
|
Does Knockout of DHPS in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
DHPS
|
response to virus
|
Hepatoma Cell Line
|
Gene: DHPS (deoxyhypusine synthase)
Type: protein-coding
Summary: This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011].
Gene Ontology: BP: glucose homeostasis, positive regulation of T cell proliferation, positive regulation of cell population proliferation, protein maturation, spermidine catabolic process, spermidine metabolic process, translation; MF: deoxyhypusine synthase activity, identical protein binding, protein binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification, hypusine biosynthesis
UniProt: P49366
Entrez ID: 1725
|
Does Knockout of ASGR2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
ASGR2
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: ASGR2 (asialoglycoprotein receptor 2)
Type: protein-coding
Summary: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: cell surface receptor signaling pathway, endocytosis, immune response; MF: D-mannose binding, asialoglycoprotein receptor activity, carbohydrate binding, fucose binding, pattern recognition receptor activity, protein binding; CC: endoplasmic reticulum quality control compartment, external side of plasma membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Thyroid hormone synthesis - Homo sapiens (human)
UniProt: P07307
Entrez ID: 433
|
Does Knockout of NOP53 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
NOP53
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: NOP53 (NOP53 ribosome biogenesis factor)
Type: protein-coding
Summary: Enables 5S rRNA binding activity; identical protein binding activity; and p53 binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; regulation of cellular protein metabolic process; and regulation of intracellular signal transduction. Located in cytosol; fibrillar center; and nucleoplasm. Colocalizes with rDNA heterochromatin. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to hypoxia, mitotic G2 DNA damage checkpoint signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein-containing complex assembly, negative regulation of signal transduction by p53 class mediator, negative regulation of transcription by RNA polymerase II, negative regulation of transcription of nucleolar large rRNA by RNA polymerase I, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K63-linked deubiquitination, protein localization to nucleolus, protein localization to nucleoplasm, protein stabilization, rRNA processing, regulation of RIG-I signaling pathway, regulation of aerobic respiration, regulation of apoptotic process, regulation of cell cycle, regulation of protein phosphorylation, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosome biogenesis; MF: 5S rRNA binding, RNA binding, identical protein binding, p53 binding, protein binding; CC: cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus, rDNA heterochromatin
Pathways:
UniProt: Q9NZM5
Entrez ID: 29997
|
Does Knockout of NOP16 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
NOP16
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: NOP16 (NOP16 nucleolar protein)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9Y3C1
Entrez ID: 51491
|
Does Knockout of ESPNL in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
ESPNL
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: ESPNL (espin like)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly and sensory perception of sound. Predicted to be located in stereocilium tip. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin filament bundle assembly, sensory perception of sound; MF: actin binding, actin filament binding, protein binding; CC: cell projection, cytoplasm, stereocilium, stereocilium tip
Pathways: Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea
UniProt: Q6ZVH7
Entrez ID: 339768
|
Does Knockout of HAUS3 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
HAUS3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: HAUS3 (HAUS augmin like complex subunit 3)
Type: protein-coding
Summary: This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: cell division, centrosome cycle, microtubule organizing center organization, regulation of microtubule nucleation, spindle assembly; CC: HAUS complex, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, intercellular bridge, microtubule, microtubule cytoskeleton, microtubule organizing center, mitochondrion, mitotic spindle, mitotic spindle microtubule, nucleoplasm, spindle
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q68CZ6
Entrez ID: 79441
|
Does Knockout of CA5A in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
CA5A
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CA5A (carbonic anhydrase 5A)
Type: protein-coding
Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: carbonate dehydratase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Metabolism, Nitrogen metabolism - Homo sapiens (human), Reversible hydration of carbon dioxide
UniProt: P35218
Entrez ID: 763
|
Does Knockout of FNDC9 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
FNDC9
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: FNDC9 (fibronectin type III domain containing 9)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8TBE3
Entrez ID: 408263
|
Does Knockout of AZIN2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
AZIN2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: AZIN2 (antizyme inhibitor 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: agmatine biosynthetic process, negative regulation of protein catabolic process, ornithine metabolic process, polyamine biosynthetic process, positive regulation of catalytic activity, positive regulation of polyamine transmembrane transport, putrescine biosynthetic process from arginine, via ornithine, spermatogenesis, trans-Golgi network membrane organization; MF: arginine decarboxylase activity, carboxy-lyase activity, catalytic activity, ornithine decarboxylase activator activity, ornithine decarboxylase activity, protein binding; CC: Golgi apparatus, axon, cell projection, cis-Golgi network, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, granular vesicle, membrane, mitochondrion, nucleus, perikaryon, perinuclear region of cytoplasm, trans-Golgi network, transport vesicle
Pathways: Agmatine biosynthesis, Arginine and proline metabolism - Homo sapiens (human), Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, putrescine biosynthesis II
UniProt: Q96A70
Entrez ID: 113451
|
Does Knockout of DHCR24 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
DHCR24
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: DHCR24 (24-dehydrocholesterol reductase)
Type: protein-coding
Summary: This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Ras protein signal transduction, amyloid precursor protein catabolic process, cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, intracellular protein localization, lipid metabolic process, male genitalia development, membrane organization, negative regulation of cell population proliferation, plasminogen activation, response to hormone, skin development, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, sterol metabolic process, tissue development; MF: Delta24(24-1) sterol reductase activity, Delta24-sterol reductase activity, FAD binding, enzyme binding, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor, peptide antigen binding, protein binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Alendronate Action Pathway, Atorvastatin Action Pathway, CHILD Syndrome, Cerivastatin Action Pathway, Cholesterol Biosynthesis with Skeletal Dysplasias, Cholesterol biosynthesis, Cholesterol biosynthesis via desmosterol, Cholesterol biosynthesis via lathosterol, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Cholesteryl ester storage disease, Chondrodysplasia Punctata II, X Linked Dominant (CDPX2), Desmosterolosis, Fluvastatin Action Pathway, Hyper-IgD syndrome, Hypercholesterolemia, Ibandronate Action Pathway, Lovastatin Action Pathway, Lysosomal Acid Lipase Deficiency (Wolman Disease), Metabolism, Metabolism of lipids, Metabolism of steroids, Mevalonic aciduria, Pamidronate Action Pathway, Pravastatin Action Pathway, Risedronate Action Pathway, Rosuvastatin Action Pathway, Simvastatin Action Pathway, Smith-Lemli-Opitz Syndrome (SLOS), Steroid Biosynthesis, Steroid biosynthesis - Homo sapiens (human), Tryptophan metabolism, Wolman disease, Zoledronate Action Pathway, cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), superpathway of cholesterol biosynthesis
UniProt: Q15392
Entrez ID: 1718
|
Does Knockout of ZCCHC7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
ZCCHC7
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: ZCCHC7 (zinc finger CCHC-type containing 7)
Type: protein-coding
Summary: Enables RNA binding activity. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: TRAMP-dependent tRNA surveillance pathway, nuclear mRNA surveillance of mRNA 3'-end processing, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent snRNA catabolic process, nuclear polyadenylation-dependent snoRNA catabolic process; MF: RNA binding, metal ion binding, nucleic acid binding, protein binding, zinc ion binding; CC: TRAMP complex, cytosol, nucleolus, nucleus
Pathways: Metabolism of RNA, Nuclear RNA decay, RNA degradation - Homo sapiens (human)
UniProt: Q8N3Z6
Entrez ID: 84186
|
Does Knockout of DMRTA1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
DMRTA1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DMRTA1 (DMRT like family A1)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in germ cell development; regulation of transcription by RNA polymerase II; and sex differentiation. Predicted to act upstream of or within male mating behavior and ovarian follicle development. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: male mating behavior, ovarian follicle development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, sex differentiation; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: Q5VZB9
Entrez ID: 63951
|
Does Knockout of SNRNP35 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
SNRNP35
|
response to virus
|
Huh-7 Cell
|
Gene: SNRNP35 (small nuclear ribonucleoprotein U11/U12 subunit 35)
Type: protein-coding
Summary: The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding, snRNA binding; CC: U12-type spliceosomal complex, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways:
UniProt: Q16560
Entrez ID: 11066
|
Does Knockout of HASPIN in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
HASPIN
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: HASPIN (histone H3 associated protein kinase)
Type: protein-coding
Summary: Enables ATP binding activity and histone kinase activity (H3-T3 specific). Involved in histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore; intracellular signal transduction; and mitotic sister chromatid cohesion. Located in centrosome; nucleoplasm; and spindle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, chromatin remodeling, chromosome organization, intracellular signal transduction, mitotic cell cycle, mitotic sister chromatid cohesion, mitotic spindle assembly checkpoint signaling, negative regulation of mitotic cell cycle phase transition, protein localization to chromosome, centromeric region, protein phosphorylation; MF: ATP binding, histone H3T3 kinase activity, histone kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, chromosome, cytoplasm, cytoskeleton, nucleoplasm, nucleus, spindle
Pathways:
UniProt: Q8TF76
Entrez ID: 83903
|
Does Knockout of PRPF4 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
PRPF4
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: PRPF4 (pre-mRNA splicing tri-snRNP complex factor PRPF4)
Type: protein-coding
Summary: The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016].
Gene Ontology: BP: RNA processing, RNA splicing, RNA splicing, via transesterification reactions, mRNA processing, mRNA splicing, via spliceosome; MF: U4 snRNA binding, U6 snRNA binding, protein binding; CC: Cajal body, U2-type precatalytic spliceosome, U4/U6 snRNP, U4/U6 x U5 tri-snRNP complex, nuclear speck, nucleoplasm, nucleus, spliceosomal complex, spliceosomal snRNP complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O43172
Entrez ID: 9128
|
Does Knockout of RETREG3 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
RETREG3
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: RETREG3 (reticulophagy regulator family member 3)
Type: protein-coding
Summary: Involved in positive regulation of neuron projection development. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagy, collagen catabolic process, endoplasmic reticulum organization, endoplasmic reticulum tubular network organization, positive regulation of neuron projection development, reticulophagy, substrate localization to autophagosome; MF: endoplasmic reticulum-autophagosome adaptor activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, membrane, protein-containing complex
Pathways:
UniProt: Q86VR2
Entrez ID: 162427
|
Does Knockout of HHAT in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
HHAT
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: HHAT (hedgehog acyltransferase)
Type: protein-coding
Summary: 'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002].
Gene Ontology: BP: N-terminal peptidyl-L-cysteine N-palmitoylation, protein modification process, smoothened signaling pathway; MF: GTP binding, O-acyltransferase activity, acyltransferase activity, nucleotide binding, palmitoyltransferase activity, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Disease, Diseases of signal transduction by growth factor receptors and second messengers, HHAT G278V doesn't palmitoylate Hh-Np, Hedgehog ligand biogenesis, Hedgehog signaling pathway - Homo sapiens (human), Hh mutants abrogate ligand secretion, Signal Transduction, Signaling by Hedgehog, Signaling events mediated by the Hedgehog family
UniProt: Q5VTY9
Entrez ID: 55733
|
Does Knockout of INPP5B in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
INPP5B
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: INPP5B (inositol polyphosphate-5-phosphatase B)
Type: protein-coding
Summary: This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: flagellated sperm motility, in utero embryonic development, inositol phosphate metabolic process, lipid metabolic process, phosphatidylinositol dephosphorylation, regulation of protein processing, signal transduction, spermatogenesis; MF: hydrolase activity, inositol phosphate phosphatase activity, inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity, metal ion binding, phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, protein binding; CC: Golgi apparatus, cytoplasm, cytoplasmic vesicle, cytosol, early endosome membrane, endoplasmic reticulum-Golgi intermediate compartment, endosome, membrane, neuron projection, phagocytic vesicle membrane, plasma membrane
Pathways: 1D-<i>myo</i>-inositol hexakisphosphate biosynthesis II (mammalian), 3-phosphoinositide degradation, D-<i>myo</i>-inositol (1,3,4)-trisphosphate biosynthesis, D-<i>myo</i>-inositol (1,4,5)-trisphosphate degradation, Inositol phosphate metabolism, Inositol phosphate metabolism - Homo sapiens (human), Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Synthesis of IP2, IP, and Ins in the cytosol, Synthesis of IP3 and IP4 in the cytosol, superpathway of D-<i>myo</i>-inositol (1,4,5)-trisphosphate metabolism, superpathway of inositol phosphate compounds
UniProt: P32019
Entrez ID: 3633
|
Does Knockout of CACYBP in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
CACYBP
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: CACYBP (calcyclin binding protein)
Type: protein-coding
Summary: The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cardiac muscle cell differentiation, cellular response to calcium ion, cellular response to leukemia inhibitory factor, heart development, positive regulation of DNA replication, response to growth hormone; MF: S100 protein binding, protein binding, protein domain specific binding, protein homodimerization activity, tubulin binding, ubiquitin protein ligase binding; CC: SCF ubiquitin ligase complex, beta-catenin destruction complex, cell body, cytoplasm, cytosol, extracellular exosome, nuclear envelope lumen, nucleoplasm, nucleus
Pathways: Gastric Cancer Network 2, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q9HB71
Entrez ID: 27101
|
Does Knockout of SMOC1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
SMOC1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: SMOC1 (SPARC related modular calcium binding 1)
Type: protein-coding
Summary: This gene encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Mutations in this gene are associated with microphthalmia and limb anomalies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].
Gene Ontology: BP: cell differentiation, extracellular matrix organization, eye development, limb development, regulation of osteoblast differentiation; MF: calcium ion binding, extracellular matrix binding, heparin binding, metal ion binding, protein binding; CC: basement membrane, extracellular region, extracellular space
Pathways:
UniProt: Q9H4F8
Entrez ID: 64093
|
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