prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of CCNK in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | CCNK | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: CCNK (cyclin K)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of ... |
Does Knockout of TANGO6 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | TANGO6 | cell proliferation | Bladder Carcinoma | Gene: TANGO6 (transport and golgi organization 6 homolog)
Type: protein-coding
Summary: Predicted to be involved in protein secretion. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q9C0B... |
Does Knockout of COPS6 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | COPS6 | cell proliferation | Monocytic Leukemia Cell Line | Gene: COPS6 (COP9 signalosome subunit 6)
Type: protein-coding
Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalo... |
Does Knockout of SASS6 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | SASS6 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: SASS6 (SAS-6 centriolar assembly protein)
Type: protein-coding
Summary: The protein encoded by this gene is a central component of centrioles and is necessary for their duplication and function. Centrioles adopt a cartwheel-shaped structure, with the encoded protein forming the hub and spokes insi... |
Does Knockout of SYT14 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | SYT14 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: SYT14 (synaptotagmin 14)
Type: protein-coding
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in t... |
Does Knockout of ASCL3 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | ASCL3 | cell proliferation | Multiple Myeloma Cell Line | Gene: ASCL3 (achaete-scute family bHLH transcription factor 3)
Type: protein-coding
Summary: Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).... |
Does Knockout of RHBDL1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | RHBDL1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: RHBDL1 (rhomboid like 1)
Type: protein-coding
Summary: This gene encodes a protein similar to Rhomboid in Drosophila which is involved in signalling in the Spitz/epidermal growth factor receptor/mitogen-activated protein kinase pathway. The Rhomboid family of proteins consists of intramembrane ser... |
Does Knockout of PPP1R13L in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | PPP1R13L | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: PPP1R13L (protein phosphatase 1 regulatory subunit 13 like)
Type: protein-coding
Summary: IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008].
Gene Onto... |
Does Knockout of BCR in Cancer Cell Line causally result in cell proliferation? | 0 | 193 | Knockout | BCR | cell proliferation | Cancer Cell Line | Gene: BCR (BCR activator of RhoGEF and GTPase)
Type: protein-coding
Summary: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located wi... |
Does Knockout of PNLIP in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | PNLIP | cell proliferation | Colonic Cancer Cell Line | Gene: PNLIP (pancreatic lipase)
Type: protein-coding
Summary: This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the e... |
Does Knockout of SLITRK6 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | SLITRK6 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: SLITRK6 (SLIT and NTRK like family member 6)
Type: protein-coding
Summary: This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares h... |
Does Knockout of RPS13 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | RPS13 | cell proliferation | T-lymphoma cell line | Gene: RPS13 (ribosomal protein S13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of SF1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | SF1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SF1 (splicing factor 1)
Type: protein-coding
Summary: This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the ear... |
Does Knockout of SEC23B in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | SEC23B | cell proliferation | Cancer Cell Line | Gene: SEC23B (SEC23 homolog B, COPII component)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat ... |
Does Knockout of TCF20 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | TCF20 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: TCF20 (transcription factor 20)
Type: protein-coding
Summary: This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the... |
Does Activation of CBX4 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | CBX4 | protein/peptide accumulation | T cell | Gene: CBX4 (chromobox 4)
Type: protein-coding
Summary: Enables SUMO binding activity; SUMO ligase activity; and enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker... |
Does Knockout of AURKB in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | AURKB | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: AURKB (aurora kinase B)
Type: protein-coding
Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and... |
Does Knockout of NUFIP1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | NUFIP1 | cell proliferation | Medulloblastoma Cell Line | Gene: NUFIP1 (nuclear FMR1 interacting protein 1)
Type: protein-coding
Summary: This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes... |
Does Knockout of OVGP1 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | OVGP1 | response to virus | Lung Cancer Cell Line | Gene: OVGP1 (oviductal glycoprotein 1)
Type: protein-coding
Summary: This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl h... |
Does Knockout of CXCR6 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | CXCR6 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: CXCR6 (C-X-C motif chemokine receptor 6)
Type: protein-coding
Summary: The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This g... |
Does Knockout of DKC1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | DKC1 | cell proliferation | Colonic Cancer Cell Line | Gene: DKC1 (dyskerin pseudouridine synthase 1)
Type: protein-coding
Summary: This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and ass... |
Does Knockout of HCRTR1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | HCRTR1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: HCRTR1 (hypocretin receptor 1)
Type: protein-coding
Summary: The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein co... |
Does Knockout of MCAT in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | MCAT | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: MCAT (malonyl-CoA-acyl carrier protein transacylase)
Type: protein-coding
Summary: The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be p... |
Does Activation of AP5Z1 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | AP5Z1 | protein/peptide accumulation | T cell | Gene: AP5Z1 (adaptor related protein complex 5 subunit zeta 1)
Type: protein-coding
Summary: This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a ... |
Does Knockout of UBA1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | UBA1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: UBA1 (ubiquitin like modifier activating enzyme 1)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and ... |
Does Knockout of ATP6AP2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | ATP6AP2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ATP6AP2 (ATPase H+ transporting accessory protein 2)
Type: protein-coding
Summary: This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intra... |
Does Knockout of SEC61A1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | SEC61A1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SEC61A1 (SEC61 translocon subunit alpha 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tigh... |
Does Knockout of ACTL9 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | ACTL9 | cell proliferation | Astrocytoma Cell Line | Gene: ACTL9 (actin like 9)
Type: protein-coding
Summary: Predicted to be located in cytoplasm. Predicted to be part of dynactin complex. Implicated in spermatogenic failure 53. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: acrosome assembly, fertilization, single ferti... |
Does Knockout of CXCL12 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | CXCL12 | response to chemicals | Glioblastoma Cell Line | Gene: CXCL12 (C-X-C motif chemokine ligand 12)
Type: protein-coding
Summary: This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and pla... |
Does Knockout of DDX19B in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | DDX19B | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: DDX19B (DEAD-box helicase 19B)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiat... |
Does Activation of KIAA1210 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | KIAA1210 | protein/peptide accumulation | T cell | Gene: KIAA1210 (KIAA1210)
Type: protein-coding
Summary: Predicted to be located in acrosomal vesicle. Predicted to colocalize with basal ectoplasmic specialization. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: acrosomal vesicle, basal ectoplasmic specialization, cytop... |
Does Knockout of CDK12 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | CDK12 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: CDK12 (cyclin dependent kinase 12)
Type: protein-coding
Summary: Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Lo... |
Does Knockout of FXR1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | FXR1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: FXR1 (FMR1 autosomal homolog 1)
Type: protein-coding
Summary: The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly wit... |
Does Knockout of ATP6V1B2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | ATP6V1B2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ATP6V1B2 (ATPase H+ transporting V1 subunit B2)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intr... |
Does Knockout of CLEC18C in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | CLEC18C | cell proliferation | Endometrial Cancer Cell Line | Gene: CLEC18C (C-type lectin domain family 18 member C)
Type: protein-coding
Summary: Enables polysaccharide binding activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and endosome. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 20... |
Does Knockout of STX18 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | STX18 | cell proliferation | Colonic Cancer Cell Line | Gene: STX18 (syntaxin 18)
Type: protein-coding
Summary: This gene encodes a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) which is part of a membrane tethering complex that includes other SNAREs and several peripheral membrane proteins, ... |
Does Knockout of PCDH1 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | PCDH1 | cell proliferation | Cancer Cell Line | Gene: PCDH1 (protocadherin 1)
Type: protein-coding
Summary: This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal developmen... |
Does Knockout of GOLGA6C in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | GOLGA6C | cell proliferation | Gastric Cancer Cell Line | Gene: GOLGA6C (golgin A6 family member C)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Golgi app... |
Does Knockout of KCNN4 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | KCNN4 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: KCNN4 (potassium calcium-activated channel subfamily N member 4)
Type: protein-coding
Summary: The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolari... |
Does Knockout of EPC2 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | EPC2 | cell proliferation | Endometrial Cancer Cell Line | Gene: EPC2 (enhancer of polycomb 2)
Type: protein-coding
Summary: Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of Piccolo NuA4 histone acetyltransferase complex. [provided by Alliance of ... |
Does Knockout of DYNLRB1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | DYNLRB1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: DYNLRB1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated i... |
Does Knockout of NPR2 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | NPR2 | response to virus | Lung Cancer Cell Line | Gene: NPR2 (natriuretic peptide receptor 2)
Type: protein-coding
Summary: This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spann... |
Does Knockout of MRPS17 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | MRPS17 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: MRPS17 (mitochondrial ribosomal protein S17)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of ILDR1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | ILDR1 | cell proliferation | Melanoma Cell Line | Gene: ILDR1 (immunoglobulin like domain containing receptor 1)
Type: protein-coding
Summary: This gene encodes a protein that contains an immunoglobulin-like domain. The encoded protein may function as a multimeric receptor at the cell surface. The expression of this gene may be a diagnostic marker for ... |
Does Knockout of IDUA in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | IDUA | response to virus | Hepatoma Cell Line | Gene: IDUA (alpha-L-iduronidase)
Type: protein-coding
Summary: This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. M... |
Does Knockout of CKLF in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | CKLF | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: CKLF (chemokine like factor)
Type: protein-coding
Summary: The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The p... |
Does Knockout of HRNR in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | HRNR | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: HRNR (hornerin)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity and transition metal ion binding activity. Involved in cell envelope organization and establishment of skin barrier. Located in cornified envelope; keratohyalin granule; and perinuclear region of cytopla... |
Does Knockout of EIF2B4 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | EIF2B4 | cell proliferation | Bladder Carcinoma | Gene: EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)
Type: protein-coding
Summary: Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta... |
Does Knockout of TUBGCP3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | TUBGCP3 | cell proliferation | Endometrial Cancer Cell Line | Gene: TUBGCP3 (tubulin gamma complex component 3)
Type: protein-coding
Summary: Enables gamma-tubulin binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Located in cytoplasm and microtubule cytoskeleton. [provided by Alliance ... |
Does Knockout of PRKACA in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | PRKACA | cell proliferation | Colonic Cancer Cell Line | Gene: PRKACA (protein kinase cAMP-activated catalytic subunit alpha)
Type: protein-coding
Summary: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the d... |
Does Knockout of DDX23 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | DDX23 | cell proliferation | Monocytic Leukemia Cell Line | Gene: DDX23 (DEAD-box helicase 23)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alterati... |
Does Inhibition of CHAF1A in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,184 | Inhibition | CHAF1A | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: CHAF1A (chromatin assembly factor 1 subunit A)
Type: protein-coding
Summary: Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7... |
Does Knockout of LHB in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | LHB | cell proliferation | Cancer Cell Line | Gene: LHB (luteinizing hormone subunit beta)
Type: protein-coding
Summary: This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit ... |
Does Knockout of ZNF710 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | ZNF710 | cell proliferation | Cancer Cell Line | Gene: ZNF710 (zinc finger protein 710)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted t... |
Does Knockout of DCUN1D5 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | DCUN1D5 | cell proliferation | Monocytic Leukemia Cell Line | Gene: DCUN1D5 (defective in cullin neddylation 1 domain containing 5)
Type: protein-coding
Summary: Enables cullin family protein binding activity. Involved in cellular response to DNA damage stimulus; positive regulation of protein neddylation; and regulation of cell growth. Located in nucleus and spin... |
Does Knockout of RPL9 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | RPL9 | cell proliferation | Medulloblastoma Cell Line | Gene: RPL9 (ribosomal protein L9)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ... |
Does Knockout of RAB18 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | RAB18 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: RAB18 (RAB18, member RAS oncogene family)
Type: protein-coding
Summary: The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a... |
Does Knockout of NLRP4 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | NLRP4 | cell proliferation | Renal Cancer Cell Line | Gene: NLRP4 (NLR family pyrin domain containing 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-bin... |
Does Knockout of RGS7BP in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | RGS7BP | cell proliferation | Monocytic Leukemia Cell Line | Gene: RGS7BP (regulator of G protein signaling 7 binding protein)
Type: protein-coding
Summary: This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protei... |
Does Knockout of ISCU in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | ISCU | cell proliferation | Colonic Cancer Cell Line | Gene: ISCU (iron-sulfur cluster assembly enzyme)
Type: protein-coding
Summary: This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, a... |
Does Knockout of TRMT5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | TRMT5 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: TRMT5 (tRNA methyltransferase 5)
Type: protein-coding
Summary: tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selec... |
Does Knockout of MIR587 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | MIR587 | response to chemicals | Glioblastoma Cell Line | Gene: MIR587 (microRNA 587)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I... |
Does Knockout of HEY2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | HEY2 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: HEY2 (hes related family bHLH transcription factor with YRPW motif 2)
Type: protein-coding
Summary: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that... |
Does Knockout of MTERF4 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | MTERF4 | cell proliferation | Gastric Cancer Cell Line | Gene: MTERF4 (mitochondrial transcription termination factor 4)
Type: protein-coding
Summary: Enables rRNA binding activity. Predicted to be involved in rRNA processing and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including mitochondrial trans... |
Does Knockout of PRKRIP1 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | PRKRIP1 | cell proliferation | Breast Cancer Cell Line | Gene: PRKRIP1 (PRKR interacting protein 1)
Type: protein-coding
Summary: Predicted to enable double-stranded RNA binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Involved in renal system process. Located in extracellular exosome. [provided by Alliance of Genome R... |
Does Knockout of CPE in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | CPE | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: CPE (carboxypeptidase E)
Type: protein-coding
Summary: This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is i... |
Does Knockout of PAQR8 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | PAQR8 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: PAQR8 (progestin and adipoQ receptor family member 8)
Type: protein-coding
Summary: Predicted to enable steroid binding activity and steroid hormone receptor activity. Predicted to be involved in response to steroid hormone. Located in Golgi apparatus and plasma membrane. [provided by Alliance of ... |
Does Knockout of NDUFAF5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | NDUFAF5 | cell proliferation | Colonic Cancer Cell Line | Gene: NDUFAF5 (NADH:ubiquinone oxidoreductase complex assembly factor 5)
Type: protein-coding
Summary: The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The comp... |
Does Knockout of ELOA in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | ELOA | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ELOA (elongin A)
Type: protein-coding
Summary: This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the poly... |
Does Knockout of GRM2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | GRM2 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: GRM2 (glutamate metabotropic receptor 2)
Type: protein-coding
Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain ... |
Does Knockout of CDC20 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | CDC20 | cell proliferation | Colonic Cancer Cell Line | Gene: CDC20 (cell division cycle 20)
Type: protein-coding
Summary: CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separati... |
Does Knockout of VCPKMT in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | VCPKMT | cell proliferation | Monocytic Leukemia Cell Line | Gene: VCPKMT (valosin containing protein lysine methyltransferase)
Type: protein-coding
Summary: Enables ATPase binding activity and protein-lysine N-methyltransferase activity. Involved in negative regulation of ATPase activity and peptidyl-lysine trimethylation. Located in cytosol. Part of protein-con... |
Does Knockout of MRPS10 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | MRPS10 | cell proliferation | Endometrial Cancer Cell Line | Gene: MRPS10 (mitochondrial ribosomal protein S10)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Activation of SEC14L6 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | SEC14L6 | response to virus | Hepatoma Cell Line | Gene: SEC14L6 (SEC14 like lipid binding 6)
Type: protein-coding
Summary: Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: B5MCN3
Entrez ID: 730005 |
Does Knockout of INTS4 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | INTS4 | cell proliferation | Renal Cancer Cell Line | Gene: INTS4 (integrator complex subunit 4)
Type: protein-coding
Summary: INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U... |
Does Knockout of ATP6V0D2 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | ATP6V0D2 | cell proliferation | Gastric Cancer Cell Line | Gene: ATP6V0D2 (ATPase H+ transporting V0 subunit d2)
Type: protein-coding
Summary: Predicted to enable proton transmembrane transporter activity. Predicted to be involved in vacuolar acidification and vacuolar transport. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATP... |
Does Knockout of GPATCH3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | GPATCH3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: GPATCH3 (G-patch domain containing 3)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and positive regulation of transcription, DNA-templated. Located i... |
Does Knockout of GGCX in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | GGCX | response to chemicals | Melanoma Cell Line | Gene: GGCX (gamma-glutamyl carboxylase)
Type: protein-coding
Summary: This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. Th... |
Does Knockout of TM7SF3 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | TM7SF3 | cell proliferation | Multiple Myeloma Cell Line | Gene: TM7SF3 (transmembrane 7 superfamily member 3)
Type: protein-coding
Summary: Involved in cellular response to unfolded protein; negative regulation of programmed cell death; and positive regulation of insulin secretion. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022... |
Does Knockout of RMND1 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | RMND1 | response to chemicals | Colorectal Cancer Cell Line | Gene: RMND1 (required for meiotic nuclear division 1 homolog)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the evolutionary conserved sif2 family of proteins that share the DUF155 domain in common. This protein is thought to be localized in the mitochondria and involved in m... |
Does Knockout of DHPS in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | DHPS | response to virus | Hepatoma Cell Line | Gene: DHPS (deoxyhypusine synthase)
Type: protein-coding
Summary: This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes t... |
Does Knockout of ASGR2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | ASGR2 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: ASGR2 (asialoglycoprotein receptor 2)
Type: protein-coding
Summary: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycop... |
Does Knockout of NOP53 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | NOP53 | cell proliferation | Breast Cancer Cell Line | Gene: NOP53 (NOP53 ribosome biogenesis factor)
Type: protein-coding
Summary: Enables 5S rRNA binding activity; identical protein binding activity; and p53 binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; regulation of cellular protein metabo... |
Does Knockout of NOP16 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | NOP16 | cell proliferation | Astrocytoma Cell Line | Gene: NOP16 (NOP16 nucleolar protein)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcri... |
Does Knockout of ESPNL in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | ESPNL | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: ESPNL (espin like)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly and sensory perception of sound. Predicted to be located in stereocilium tip. Predicted to be active in cytoplasm. [provided by Alliance ... |
Does Knockout of HAUS3 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | HAUS3 | cell proliferation | Glioblastoma Cell Line | Gene: HAUS3 (HAUS augmin like complex subunit 3)
Type: protein-coding
Summary: This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes an... |
Does Knockout of CA5A in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | CA5A | cell proliferation | Glioblastoma Cell Line | Gene: CA5A (carbonic anhydrase 5A)
Type: protein-coding
Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, ... |
Does Knockout of FNDC9 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | FNDC9 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: FNDC9 (fibronectin type III domain containing 9)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8TBE3
Entrez ID: 408263 |
Does Knockout of AZIN2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | AZIN2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: AZIN2 (antizyme inhibitor 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylas... |
Does Knockout of DHCR24 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | DHCR24 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: DHCR24 (24-dehydrocholesterol reductase)
Type: protein-coding
Summary: This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader seq... |
Does Knockout of ZCCHC7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | ZCCHC7 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: ZCCHC7 (zinc finger CCHC-type containing 7)
Type: protein-coding
Summary: Enables RNA binding activity. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: TRAMP-dependent tRNA surveillance pathway, nuclear mRNA surveillance of mRNA 3'... |
Does Knockout of DMRTA1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | DMRTA1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: DMRTA1 (DMRT like family A1)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in germ cell development; regulation of transcription by RNA polymerase II; and sex differentiation. Predicted to act upstream of or within male matin... |
Does Knockout of SNRNP35 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | SNRNP35 | response to virus | Huh-7 Cell | Gene: SNRNP35 (small nuclear ribonucleoprotein U11/U12 subunit 35)
Type: protein-coding
Summary: The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is... |
Does Knockout of HASPIN in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | HASPIN | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: HASPIN (histone H3 associated protein kinase)
Type: protein-coding
Summary: Enables ATP binding activity and histone kinase activity (H3-T3 specific). Involved in histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore; intracellular signal transduction; ... |
Does Knockout of PRPF4 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | PRPF4 | cell proliferation | Prostate Cancer Cell Line | Gene: PRPF4 (pre-mRNA splicing tri-snRNP complex factor PRPF4)
Type: protein-coding
Summary: The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a... |
Does Knockout of RETREG3 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | RETREG3 | response to chemicals | Monocytic Leukemia Cell Line | Gene: RETREG3 (reticulophagy regulator family member 3)
Type: protein-coding
Summary: Involved in positive regulation of neuron projection development. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagy, collagen catabolic proce... |
Does Knockout of HHAT in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | HHAT | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: HHAT (hedgehog acyltransferase)
Type: protein-coding
Summary: 'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002].
Gene Ontology: BP: N-terminal peptidyl-L-c... |
Does Knockout of INPP5B in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | INPP5B | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: INPP5B (inositol polyphosphate-5-phosphatase B)
Type: protein-coding
Summary: This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the ... |
Does Knockout of CACYBP in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | CACYBP | cell proliferation | Multiple Myeloma Cell Line | Gene: CACYBP (calcyclin binding protein)
Type: protein-coding
Summary: The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin ... |
Does Knockout of SMOC1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | SMOC1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: SMOC1 (SPARC related modular calcium binding 1)
Type: protein-coding
Summary: This gene encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Mutations in this gene are associated with microphthalmia and limb anomalies. Alternatively spliced transcri... |
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