prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of NPY1R in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | NPY1R | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: NPY1R (neuropeptide Y receptor Y1)
Type: protein-coding
Summary: This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded recep... |
Does Knockout of MROH2B in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | MROH2B | response to chemicals | Melanoma Cell Line | Gene: MROH2B (maestro heat like repeat family member 2B)
Type: protein-coding
Summary: Predicted to be involved in protein kinase A signaling. Predicted to be located in acrosomal vesicle and sperm midpiece. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differenti... |
Does Knockout of PDIA3 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | PDIA3 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: PDIA3 (protein disulfide isomerase family A member 3)
Type: protein-coding
Summary: This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a ... |
Does Knockout of TOP2A in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | TOP2A | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: TOP2A (DNA topoisomerase II alpha)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the r... |
Does Knockout of PPCDC in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | PPCDC | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: PPCDC (phosphopantothenoylcysteine decarboxylase)
Type: protein-coding
Summary: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantoth... |
Does Activation of CISD1 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | CISD1 | response to virus | Hepatoma Cell Line | Gene: CISD1 (CDGSH iron sulfur domain 1)
Type: protein-coding
Summary: This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in reg... |
Does Knockout of EMG1 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | EMG1 | response to chemicals | Monocytic Leukemia Cell Line | Gene: EMG1 (EMG1 N1-specific pseudouridine methyltransferase)
Type: protein-coding
Summary: This gene encodes an essential, conserved eukaryotic protein that methylates pseudouridine in 18S rRNA. The related protein in yeast is a component of the small subunit processome and is essential for biogenesis ... |
Does Knockout of PSMG4 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | PSMG4 | cell proliferation | Colorectal Cancer Cell Line | Gene: PSMG4 (proteasome assembly chaperone 4)
Type: protein-coding
Summary: Predicted to be involved in proteasome assembly. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein-containing complex binding; CC: cytoso... |
Does Knockout of EIF1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | EIF1 | cell proliferation | Medulloblastoma Cell Line | Gene: EIF1 (eukaryotic translation initiation factor 1)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in regulation of translational initiation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of gene ex... |
Does Knockout of TM9SF2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | TM9SF2 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: TM9SF2 (transmembrane 9 superfamily member 2)
Type: protein-coding
Summary: This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain whic... |
Does Knockout of RPL32 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | RPL32 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: RPL32 (ribosomal protein L32)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of GTF2A2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | GTF2A2 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: GTF2A2 (general transcription factor IIA subunit 2)
Type: protein-coding
Summary: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313... |
Does Knockout of TRAPPC1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | TRAPPC1 | cell proliferation | Colonic Cancer Cell Line | Gene: TRAPPC1 (trafficking protein particle complex subunit 1)
Type: protein-coding
Summary: This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) ... |
Does Knockout of RPS12 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | RPS12 | cell proliferation | Melanoma Cell Line | Gene: RPS12 (ribosomal protein S12)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of MCRS1 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | MCRS1 | cell proliferation | Renal Cancer Cell Line | Gene: MCRS1 (microspherule protein 1)
Type: protein-coding
Summary: Enables RNA binding activity and telomerase inhibitor activity. Involved in histone H4 acetylation; negative regulation of DNA metabolic process; and positive regulation of protein localization to nucleolus. Located in cytoplasm; nucleo... |
Does Knockout of SH3KBP1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | SH3KBP1 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: SH3KBP1 (SH3 domain containing kinase binding protein 1)
Type: protein-coding
Summary: This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interact... |
Does Knockout of DARS2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | DARS2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: DARS2 (aspartyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoenc... |
Does Knockout of RNF4 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | RNF4 | cell proliferation | Monocytic Leukemia Cell Line | Gene: RNF4 (ring finger protein 4)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcriptio... |
Does Knockout of FHDC1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | FHDC1 | cell proliferation | Colonic Cancer Cell Line | Gene: FHDC1 (FH2 domain containing 1)
Type: protein-coding
Summary: Predicted to enable actin binding activity and microtubule binding activity. Involved in Golgi ribbon formation; cilium assembly; and stress fiber assembly. Located in cilium and microtubule. [provided by Alliance of Genome Resources, A... |
Does Knockout of PDCD4 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | PDCD4 | cell proliferation | Cancer Cell Line | Gene: PDCD4 (programmed cell death 4)
Type: protein-coding
Summary: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [pro... |
Does Knockout of SNX5 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 1 | 1,480 | Knockout | SNX5 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: SNX5 (sorting nexin 5)
Type: protein-coding
Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, th... |
Does Knockout of SEMA3F in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | SEMA3F | cell proliferation | Glioblastoma Cell Line | Gene: SEMA3F (semaphorin 3F)
Type: protein-coding
Summary: This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-termina... |
Does Knockout of PLCD3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | PLCD3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: PLCD3 (phospholipase C delta 3)
Type: protein-coding
Summary: This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and... |
Does Knockout of XPO1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | XPO1 | cell proliferation | Colonic Cancer Cell Line | Gene: XPO1 (exportin 1)
Type: protein-coding
Summary: This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several ce... |
Does Activation of MAGEC3 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | MAGEC3 | response to virus | Hepatoma Cell Line | Gene: MAGEC3 (MAGE family member C3)
Type: protein-coding
Summary: This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosome Xq2... |
Does Knockout of MAGEF1 in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | MAGEF1 | RNA accumulation | Monocytic Leukemia Cell Line | Gene: MAGEF1 (MAGE family member F1)
Type: protein-coding
Summary: This intronless gene encodes a member of the MAGE superfamily. It is ubiquitously expressed in normal tissues and in tumor cells. This gene includes a microsatellite repeat in the coding region. [provided by RefSeq, Jul 2008].
G... |
Does Knockout of CST3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | CST3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: CST3 (cystatin C)
Type: protein-coding
Summary: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhib... |
Does Knockout of VCP in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | VCP | cell proliferation | Ewing's Sarcoma Cell Line | Gene: VCP (valosin containing protein)
Type: protein-coding
Summary: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF... |
Does Knockout of TNNI1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | TNNI1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: TNNI1 (troponin I1, slow skeletal type)
Type: protein-coding
Summary: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subuni... |
Does Knockout of MTPAP in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | MTPAP | cell proliferation | Endometrial Cancer Cell Line | Gene: MTPAP (mitochondrial poly(A) polymerase)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.... |
Does Knockout of SERPING1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | SERPING1 | cell proliferation | Medulloblastoma Cell Line | Gene: SERPING1 (serpin family G member 1)
Type: protein-coding
Summary: This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates comp... |
Does Knockout of COG3 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | COG3 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: COG3 (component of oligomeric golgi complex 3)
Type: protein-coding
Summary: This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result i... |
Does Knockout of TANC1 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | TANC1 | cell proliferation | Glioblastoma Cell Line | Gene: TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1)
Type: protein-coding
Summary: Predicted to be involved in regulation of postsynapse organization. Predicted to act upstream of or within dendritic spine maintenance; myoblast fusion; and visual learning. Predicted to be ... |
Does Knockout of CERS5 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | CERS5 | cell proliferation | Breast Cancer Cell Line | Gene: CERS5 (ceramide synthase 5)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pat... |
Does Knockout of EIF2B3 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | EIF2B3 | cell proliferation | Bladder Carcinoma | Gene: EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)
Type: protein-coding
Summary: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function ... |
Does Knockout of PIK3R4 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | PIK3R4 | response to virus | Lung Cancer Cell Line | Gene: PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4)
Type: protein-coding
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of phosphatidylinositol 3-kinase activity; receptor catabolic process; and regulation of cytokinesis. Located in late ... |
Does Knockout of ABO in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | ABO | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase)
Type: protein-coding
Summary: This gene encodes proteins related to the first discovered blood group system, ABO. Variation in the ABO gene (chromosome 9q34.2) is the basis of the ABO blood group, thus the p... |
Does Knockout of CXCL14 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | CXCL14 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: CXCL14 (C-X-C motif chemokine ligand 14)
Type: protein-coding
Summary: This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys)... |
Does Knockout of INO80D in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | INO80D | cell proliferation | Hepatoma Cell Line | Gene: INO80D (INO80 complex subunit D)
Type: protein-coding
Summary: Predicted to be involved in DNA recombination and DNA repair. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage respon... |
Does Knockout of TVP23C in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | TVP23C | cell proliferation | Endometrial Cancer Cell Line | Gene: TVP23C (trans-golgi network vesicle protein 23 homolog C)
Type: protein-coding
Summary: Predicted to be involved in protein secretion and vesicle-mediated transport. Predicted to be integral component of membrane. Predicted to be integral component of Golgi membrane. [provided by Alliance of Genom... |
Does Knockout of USP37 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | USP37 | cell proliferation | Bladder Carcinoma | Gene: USP37 (ubiquitin specific peptidase 37)
Type: protein-coding
Summary: Enables cysteine-type endopeptidase activity; protein kinase binding activity; and thiol-dependent deubiquitinase. Involved in G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of DNA replication. L... |
Does Knockout of LPAR5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | LPAR5 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: LPAR5 (lysophosphatidic acid receptor 5)
Type: protein-coding
Summary: This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates num... |
Does Knockout of ENTPD4 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | ENTPD4 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)
Type: protein-coding
Summary: This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded p... |
Does Knockout of UBE2I in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | UBE2I | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: UBE2I (ubiquitin conjugating enzyme E2 I)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enz... |
Does Knockout of SYNJ2BP in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | SYNJ2BP | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: SYNJ2BP (synaptojanin 2 binding protein)
Type: protein-coding
Summary: Predicted to enable type II activin receptor binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of sprouting angiogenesis; and regulation of signal ... |
Does Knockout of GINS4 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | GINS4 | cell proliferation | T-lymphoma cell line | Gene: GINS4 (GINS complex subunit 4)
Type: protein-coding
Summary: The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast a... |
Does Knockout of DEFB105B in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | DEFB105B | cell proliferation | Colorectal Cancer Cell Line | Gene: DEFB105B (defensin beta 105B)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins.... |
Does Knockout of LIAS in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | LIAS | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: LIAS (lipoic acid synthetase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a pote... |
Does Knockout of ZC3H4 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | ZC3H4 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: ZC3H4 (zinc finger CCCH-type containing 4)
Type: protein-coding
Summary: This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues a... |
Does Knockout of ZBTB17 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | ZBTB17 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ZBTB17 (zinc finger and BTB domain containing 17)
Type: protein-coding
Summary: This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008].
... |
Does Knockout of GTF3C4 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | GTF3C4 | cell proliferation | T-lymphoma cell line | Gene: GTF3C4 (general transcription factor IIIC subunit 4)
Type: protein-coding
Summary: Predicted to enable enzyme activator activity. Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and tRNA transcription by RNA polymerase ... |
Does Knockout of HDLBP in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | HDLBP | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: HDLBP (high density lipoprotein binding protein)
Type: protein-coding
Summary: The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provid... |
Does Knockout of CLIC5 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | CLIC5 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: CLIC5 (chloride intracellular channel 5)
Type: protein-coding
Summary: This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes includin... |
Does Knockout of USP32 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | USP32 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: USP32 (ubiquitin specific peptidase 32)
Type: protein-coding
Summary: Enables thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regu... |
Does Knockout of TECPR1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | TECPR1 | cell proliferation | Ovarian Cancer Cell Line | Gene: TECPR1 (tectonin beta-propeller repeat containing 1)
Type: protein-coding
Summary: This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy... |
Does Knockout of NACA in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | NACA | cell proliferation | T-lymphoma cell line | Gene: NACA (nascent polypeptide associated complex subunit alpha)
Type: protein-coding
Summary: This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide... |
Does Knockout of ACP1 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | ACP1 | response to virus | Lung Cancer Cell Line | Gene: ACP1 (acid phosphatase 1)
Type: protein-coding
Summary: The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophos... |
Does Knockout of RALB in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | RALB | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: RALB (RAS like proto-oncogene B)
Type: protein-coding
Summary: This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [pr... |
Does Knockout of NDUFS2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | NDUFS2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)
Type: protein-coding
Summary: The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, ... |
Does Knockout of MED11 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | MED11 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: MED11 (mediator complex subunit 11)
Type: protein-coding
Summary: MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008].
Gene Ontolog... |
Does Knockout of HSP90AB1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | HSP90AB1 | cell proliferation | Medulloblastoma Cell Line | Gene: HSP90AB1 (heat shock protein 90 alpha family class B member 1)
Type: protein-coding
Summary: This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the consti... |
Does Activation of CPO in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | CPO | protein/peptide accumulation | T cell | Gene: CPO (carboxypeptidase O)
Type: protein-coding
Summary: This gene is a member of the metallocarboxypeptidase gene family. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: proteolysis; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, ... |
Does Knockout of GAPDH in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | GAPDH | cell proliferation | Medulloblastoma Cell Line | Gene: GAPDH (glyceraldehyde-3-phosphate dehydrogenase)
Type: protein-coding
Summary: This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct funct... |
Does Knockout of TXN2 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | TXN2 | response to chemicals | Monocytic Leukemia Cell Line | Gene: TXN2 (thioredoxin 2)
Type: protein-coding
Summary: This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in prote... |
Does Knockout of LINC01587 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | LINC01587 | response to chemicals | Glioblastoma Cell Line | Gene: LINC01587 (long intergenic non-protein coding RNA 1587)
Type: ncRNA
Summary: This gene is expressed in neuroblastoma; however, the function of this gene is not yet determined. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 10141 |
Does Knockout of DARS2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 2,459 | Knockout | DARS2 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: DARS2 (aspartyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoenc... |
Does Knockout of GOLGA8N in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | GOLGA8N | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: GOLGA8N (golgin A8 family member N)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Apr... |
Does Knockout of NAA25 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | NAA25 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit)
Type: protein-coding
Summary: This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by ... |
Does Knockout of NIFK in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | NIFK | cell proliferation | Medulloblastoma Cell Line | Gene: NIFK (nucleolar protein interacting with the FHA domain of MKI67)
Type: protein-coding
Summary: This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple ... |
Does Knockout of DEPTOR in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | DEPTOR | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: DEPTOR (DEP domain containing MTOR interacting protein)
Type: protein-coding
Summary: Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. [provided by Alliance of Genome Resources, Apr ... |
Does Knockout of VHLL in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | VHLL | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: VHLL (VHL like)
Type: protein-coding
Summary: Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivat... |
Does Knockout of RBBP6 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | RBBP6 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: RBBP6 (RB binding protein 6, ubiquitin ligase)
Type: protein-coding
Summary: The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the acti... |
Does Knockout of PRB1 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | PRB1 | cell proliferation | Neuroblastoma Cell Line | Gene: PRB1 (proline rich protein BstNI subfamily 1)
Type: protein-coding
Summary: This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secreti... |
Does Knockout of PSMB7 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | PSMB7 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: PSMB7 (proteasome 20S subunit beta 7)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rin... |
Does Knockout of CCDC144A in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | CCDC144A | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: CCDC144A (coiled-coil domain containing 144A)
Type: protein-coding
Summary: Predicted to enable calcium oxalate binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A2RUR9
Entrez ID: 9720 |
Does Knockout of RPL13 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | RPL13 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: RPL13 (ribosomal protein L13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Activation of AS3MT in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | AS3MT | response to virus | Hepatoma Cell Line | Gene: AS3MT (arsenite methyltransferase)
Type: protein-coding
Summary: AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008].
Gene On... |
Does Knockout of CSGALNACT1 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | CSGALNACT1 | cell proliferation | Glioblastoma Cell Line | Gene: CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1)
Type: protein-coding
Summary: This gene encodes an enzyme that transfers N-acetylglucosamine (GalNAc) to the core tetrasaccharide linker and to elongating chondroitin sulfate chains in proteoglycans. Knockout of the orthologous m... |
Does Knockout of AAR2 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | AAR2 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: AAR2 (AAR2 splicing factor)
Type: protein-coding
Summary: This gene encodes the homolog of the yeast A1-alpha2 repressin protein that is involved in mRNA splicing. Alternately spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: RNA... |
Does Knockout of POMGNT1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | POMGNT1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: POMGNT1 (protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-))
Type: protein-coding
Summary: This gene encodes a type II transmembrane protein that resides in the Golgi apparatus. It participates in O-mannosyl glycosylation and is specific for alpha linked terminal mannose. Mutat... |
Does Knockout of LCE1A in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | LCE1A | cell proliferation | Ovarian Cancer Cell Line | Gene: LCE1A (late cornified envelope 1A)
Type: protein-coding
Summary: LCE1A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these gen... |
Does Knockout of AGR2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | AGR2 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: AGR2 (anterior gradient 2, protein disulphide isomerase family member)
Type: protein-coding
Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protei... |
Does Knockout of RPAP1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | RPAP1 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: RPAP1 (RNA polymerase II associated protein 1)
Type: protein-coding
Summary: This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012].
Gene Ontology: MF: DN... |
Does Knockout of NME5 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | NME5 | cell proliferation | Monocytic Leukemia Cell Line | Gene: NME5 (NME/NM23 family member 5)
Type: protein-coding
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and spermatid development. Predicted to act upstream of or wit... |
Does Activation of DACH2 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | DACH2 | protein/peptide accumulation | T cell | Gene: DACH2 (dachshund family transcription factor 2)
Type: protein-coding
Summary: This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded prote... |
Does Knockout of ACIN1 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | ACIN1 | cell proliferation | Breast Cancer Cell Line | Gene: ACIN1 (apoptotic chromatin condensation inducer 1)
Type: protein-coding
Summary: Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activati... |
Does Knockout of ZBTB37 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | ZBTB37 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ZBTB37 (zinc finger and BTB domain containing 37)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleoplasm. [p... |
Does Knockout of IFIT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | IFIT1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: IFIT1 (interferon induced protein with tetratricopeptide repeats 1)
Type: protein-coding
Summary: This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and transla... |
Does Knockout of LIN54 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | LIN54 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: LIN54 (lin-54 DREAM MuvB core complex component)
Type: protein-coding
Summary: LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010].
Gene Ontology: BP: nucleosome organization, r... |
Does Knockout of ZFYVE27 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | ZFYVE27 | response to virus | Huh-7 Cell | Gene: ZFYVE27 (zinc finger FYVE-type containing 27)
Type: protein-coding
Summary: This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been repo... |
Does Knockout of MIS18BP1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | MIS18BP1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: MIS18BP1 (MIS18 binding protein 1)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be involved in cell division. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CENP-A containing chromatin... |
Does Knockout of XRN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | XRN1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: XRN1 (5'-3' exoribonuclease 1)
Type: protein-coding
Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA ... |
Does Knockout of NOL6 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | NOL6 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: NOL6 (nucleolar protein 6)
Type: protein-coding
Summary: The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNas... |
Does Knockout of DDX47 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | DDX47 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: DDX47 (DEAD-box helicase 47)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alterati... |
Does Knockout of DRC3 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | DRC3 | cell proliferation | Cancer Cell Line | Gene: DRC3 (dynein regulatory complex subunit 3)
Type: protein-coding
Summary: Located in axoneme. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: axoneme, cell projection, cilium, cytoplasm, cytoskeleton, motile cilium, sperm flagellum
Pathways:
UniPr... |
Does Knockout of ADRA1D in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | ADRA1D | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: ADRA1D (adrenoceptor alpha 1D)
Type: protein-coding
Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B a... |
Does Knockout of MPPE1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | MPPE1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: MPPE1 (metallophosphoesterase 1)
Type: protein-coding
Summary: Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Involved in GPI anchor biosynthetic process. Located in Golgi apparatus and nucleoplasm... |
Does Knockout of SNX14 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | SNX14 | response to chemicals | Melanoma Cell Line | Gene: SNX14 (sorting nexin 14)
Type: protein-coding
Summary: This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling... |
Does Knockout of DDX54 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | DDX54 | cell proliferation | T-lymphoma cell line | Gene: DDX54 (DEAD-box helicase 54)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alterati... |
Does Knockout of TM7SF2 in Cancer Cell Line causally result in cell proliferation? | 0 | 193 | Knockout | TM7SF2 | cell proliferation | Cancer Cell Line | Gene: TM7SF2 (transmembrane 7 superfamily member 2)
Type: protein-coding
Summary: Enables delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in endoplasmic reticulum. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontolo... |
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