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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of NPY1R in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
NPY1R
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NPY1R (neuropeptide Y receptor Y1)
Type: protein-coding
Summary: This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cell communication, feeding behavior, glucose metabolic process, locomotory behavior, neuropeptide signaling pathway, outflow tract morphogenesis, regulation of blood pressure, regulation of multicellular organism growth, sensory perception of pain, signal transduction, signaling; MF: G protein-coupled receptor activity, neuropeptide Y receptor activity, neuropeptide binding, neuropeptide receptor activity, pancreatic polypeptide receptor activity, peptide YY receptor activity, protein binding; CC: membrane, neuron projection, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Endothelin Pathways, G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide GPCRs, Peptide ligand-binding receptors, Regulation of lipolysis in adipocytes - Homo sapiens (human), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Homo sapiens (human)
UniProt: P25929
Entrez ID: 4886
|
Does Knockout of MROH2B in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
MROH2B
|
response to chemicals
|
Melanoma Cell Line
|
Gene: MROH2B (maestro heat like repeat family member 2B)
Type: protein-coding
Summary: Predicted to be involved in protein kinase A signaling. Predicted to be located in acrosomal vesicle and sperm midpiece. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, protein kinase A signaling, spermatogenesis; CC: acrosomal vesicle, cell projection, cilium, cytoplasm, cytoplasmic vesicle, motile cilium, sperm flagellum, sperm midpiece
Pathways:
UniProt: Q7Z745
Entrez ID: 133558
|
Does Knockout of PDIA3 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
PDIA3
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: PDIA3 (protein disulfide isomerase family A member 3)
Type: protein-coding
Summary: This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016].
Gene Ontology: BP: adaptive immune response, cellular response to interleukin-7, extrinsic apoptotic signaling pathway, immune system process, peptide antigen assembly with MHC class I protein complex, platelet aggregation, positive regulation of extrinsic apoptotic signaling pathway, protein folding, protein folding in endoplasmic reticulum, response to endoplasmic reticulum stress; MF: RNA binding, cysteine-type endopeptidase activity, disulfide oxidoreductase activity, identical protein binding, isomerase activity, lncRNA binding, phospholipase C activity, protein binding, protein disulfide isomerase activity, protein-disulfide reductase activity; CC: MHC class I peptide loading complex, Tapasin-ERp57 complex, cell surface, endoplasmic reticulum, endoplasmic reticulum lumen, extracellular exosome, extracellular space, focal adhesion, melanosome, nucleus, phagocytic vesicle, recycling endosome membrane
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Homo sapiens (human), Antigen processing-Cross presentation, Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, Class I MHC mediated antigen processing & presentation, ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Immune System, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Post-translational protein modification, Prion disease pathway, Protein processing in endoplasmic reticulum - Homo sapiens (human)
UniProt: P30101
Entrez ID: 2923
|
Does Knockout of TOP2A in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
TOP2A
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: TOP2A (DNA topoisomerase II alpha)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA topological change, apoptotic chromosome condensation, chromatin organization, chromosome condensation, chromosome segregation, embryonic cleavage, female meiotic nuclear division, hematopoietic progenitor cell differentiation, positive regulation of apoptotic process, positive regulation of single stranded viral RNA replication via double stranded DNA intermediate, positive regulation of transcription by RNA polymerase II, regulation of circadian rhythm, resolution of meiotic recombination intermediates, rhythmic process, sister chromatid segregation; MF: ATP binding, ATP-dependent activity, acting on DNA, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, RNA binding, chromatin binding, isomerase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein kinase C binding, ubiquitin binding; CC: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex, centriole, chromosome, centromeric region, condensed chromosome, cytoplasm, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, Etoposide Action Pathway, Etoposide Metabolism Pathway, G0 and Early G1, Gastric Cancer Network 1, Gastric Cancer Network 2, Metabolism of proteins, Mitotic G1 phase and G1/S transition, Post-translational protein modification, Retinoblastoma gene in cancer, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Teniposide Action Pathway, Teniposide Metabolism Pathway, Transcription of E2F targets under negative control by DREAM complex, Validated transcriptional targets of deltaNp63 isoforms
UniProt: P11388
Entrez ID: 7153
|
Does Knockout of PPCDC in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
PPCDC
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: PPCDC (phosphopantothenoylcysteine decarboxylase)
Type: protein-coding
Summary: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: coenzyme A biosynthetic process; MF: FMN binding, carboxy-lyase activity, catalytic activity, identical protein binding, lyase activity, phosphopantothenoylcysteine decarboxylase activity, protein binding; CC: cytosol, phosphopantothenoylcysteine decarboxylase complex
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA Biosynthesis, Pantothenate and CoA biosynthesis - Homo sapiens (human), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q96CD2
Entrez ID: 60490
|
Does Activation of CISD1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
CISD1
|
response to virus
|
Hepatoma Cell Line
|
Gene: CISD1 (CDGSH iron sulfur domain 1)
Type: protein-coding
Summary: This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: intracellular iron ion homeostasis, protein maturation, regulation of autophagy, regulation of cellular respiration; MF: 2 iron, 2 sulfur cluster binding, L-cysteine transaminase activity, identical protein binding, iron-sulfur cluster binding, metal ion binding, protein homodimerization activity, pyridoxal phosphate binding, transferase activity; CC: membrane, mitochondrial outer membrane, mitochondrion
Pathways: Adipogenesis
UniProt: Q9NZ45
Entrez ID: 55847
|
Does Knockout of EMG1 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
EMG1
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: EMG1 (EMG1 N1-specific pseudouridine methyltransferase)
Type: protein-coding
Summary: This gene encodes an essential, conserved eukaryotic protein that methylates pseudouridine in 18S rRNA. The related protein in yeast is a component of the small subunit processome and is essential for biogenesis of the ribosomal 40S subunit. A mutation in this gene has been associated with Bowen-Conradi syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: blastocyst development, methylation, nucleologenesis, rRNA base methylation, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, identical protein binding, methyltransferase activity, protein binding, rRNA (pseudouridine) methyltransferase activity, rRNA binding, transferase activity; CC: chromosome, cytoplasm, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q92979
Entrez ID: 10436
|
Does Knockout of PSMG4 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
PSMG4
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: PSMG4 (proteasome assembly chaperone 4)
Type: protein-coding
Summary: Predicted to be involved in proteasome assembly. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein-containing complex binding; CC: cytosol, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Proteasome assembly
UniProt: Q5JS54
Entrez ID: 389362
|
Does Knockout of EIF1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
EIF1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: EIF1 (eukaryotic translation initiation factor 1)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in regulation of translational initiation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of gene expression, regulation of primary metabolic process, regulation of translational initiation, translation, translational initiation; MF: RNA binding, protein binding, ribosomal small subunit binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, multi-eIF complex, nucleus
Pathways: RNA transport - Homo sapiens (human), Translation Factors, eukaryotic protein translation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: P41567
Entrez ID: 10209
|
Does Knockout of TM9SF2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
TM9SF2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TM9SF2 (transmembrane 9 superfamily member 2)
Type: protein-coding
Summary: This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: ceramide metabolic process, glycosphingolipid biosynthetic process, protein localization to membrane, regulation of heparan sulfate proteoglycan biosynthetic process; CC: Golgi apparatus, cytoplasm, cytoskeleton, endosome, endosome membrane, extracellular exosome, membrane, microtubule organizing center, plasma membrane
Pathways:
UniProt: Q99805
Entrez ID: 9375
|
Does Knockout of RPL32 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
RPL32
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RPL32 (ribosomal protein L32)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62910
Entrez ID: 6161
|
Does Knockout of GTF2A2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
GTF2A2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: GTF2A2 (general transcription factor IIA subunit 2)
Type: protein-coding
Summary: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: RNA polymerase II general transcription initiation factor activity, RNA polymerase II general transcription initiation factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, TBP-class protein binding, protein binding, protein heterodimerization activity, protein homodimerization activity; CC: cytosol, nucleoplasm, nucleus, transcription factor TFIIA complex, transcription factor TFIID complex
Pathways: Basal transcription factors - Homo sapiens (human), Disease, ESR-mediated signaling, Estrogen-dependent gene expression, Eukaryotic Transcription Initiation, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by Nuclear Receptors, Transcription of the HIV genome, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human)
UniProt: P52657
Entrez ID: 2958
|
Does Knockout of TRAPPC1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
TRAPPC1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TRAPPC1 (trafficking protein particle complex subunit 1)
Type: protein-coding
Summary: This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, azurophil granule lumen, cytoplasm, cytosol, endoplasmic reticulum, extracellular region
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9Y5R8
Entrez ID: 58485
|
Does Knockout of RPS12 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
RPS12
|
cell proliferation
|
Melanoma Cell Line
|
Gene: RPS12 (ribosomal protein S12)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maintenance of translational fidelity, positive regulation of canonical Wnt signaling pathway, ribosomal small subunit biogenesis, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: Golgi apparatus, cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small-subunit processome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P25398
Entrez ID: 6206
|
Does Knockout of MCRS1 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
MCRS1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: MCRS1 (microspherule protein 1)
Type: protein-coding
Summary: Enables RNA binding activity and telomerase inhibitor activity. Involved in histone H4 acetylation; negative regulation of DNA metabolic process; and positive regulation of protein localization to nucleolus. Located in cytoplasm; nucleolus; and nucleoplasm. Part of Ino80 complex; MLL1 complex; and histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin organization, chromatin remodeling, negative regulation of telomere maintenance via telomere lengthening, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein localization to nucleolus, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, protein modification process, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, regulation of telomere maintenance, telomere maintenance; MF: G-quadruplex RNA binding, poly(G) binding, poly(U) RNA binding, protein binding, telomerase inhibitor activity; CC: Ino80 complex, MLL1 complex, NSL complex, centriolar satellite, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, dendrite, histone acetyltransferase complex, kinetochore, lysosome, nuclear body, nucleolus, nucleoplasm, nucleus, perikaryon, spindle pole
Pathways: 3q29 copy number variation syndrome, Chromatin modifying enzymes, Chromatin organization, DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Global Genome Nucleotide Excision Repair (GG-NER), HATs acetylate histones, Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q96EZ8
Entrez ID: 10445
|
Does Knockout of SH3KBP1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
SH3KBP1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: SH3KBP1 (SH3 domain containing kinase binding protein 1)
Type: protein-coding
Summary: This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: actin filament organization, apoptotic process, cell migration, cell-cell signaling, cytoskeleton organization, endocytosis, positive regulation of B cell activation, regulation of cell shape; MF: SH3 domain binding, protein binding, ubiquitin protein ligase binding; CC: GABA-ergic synapse, anchoring junction, cell-cell junction, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, cytosol, endocytic vesicle, focal adhesion, glutamatergic synapse, membrane, neuron projection, plasma membrane, postsynaptic density, synapse
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Axon guidance, Bacterial Infection Pathways, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Developmental Biology, Disease, EGF-EGFR signaling pathway, EGFR downregulation, EGFR1, Endocytosis - Homo sapiens (human), Immune System, Infectious disease, InlB-mediated entry of Listeria monocytogenes into host cell, Internalization of ErbB1, KitReceptor, Listeria monocytogenes entry into host cells, Membrane Trafficking, Negative regulation of MET activity, Nervous system development, Potential therapeutics for SARS, Reelin signalling pathway, SARS-CoV Infections, Signal Transduction, Signaling by EGFR, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Signaling by the B Cell Receptor (BCR), Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Vesicle-mediated transport, Viral Infection Pathways, cbl mediated ligand-induced downregulation of egf receptors pathway, sprouty regulation of tyrosine kinase signals
UniProt: Q96B97
Entrez ID: 30011
|
Does Knockout of DARS2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
DARS2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DARS2 (aspartyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq, Nov 2009].
Gene Ontology: BP: aspartyl-tRNA aminoacylation, mitochondrial asparaginyl-tRNA aminoacylation, tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, aspartate-tRNA ligase activity, aspartate-tRNA(Asn) ligase activity, ligase activity, nucleic acid binding, nucleotide binding, protein binding, protein homodimerization activity, tRNA binding; CC: cytoplasm, membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Metabolism of proteins, Mitochondrial tRNA aminoacylation, Translation, tRNA Aminoacylation, tRNA charging
UniProt: Q6PI48
Entrez ID: 55157
|
Does Knockout of RNF4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
RNF4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RNF4 (ring finger protein 4)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010].
Gene Ontology: BP: DNA damage response, negative regulation of protein localization to chromatin, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein K6-linked ubiquitination, protein K63-linked ubiquitination, protein autoubiquitination, protein ubiquitination, regulation of kinetochore assembly, regulation of spindle assembly, response to arsenic-containing substance; MF: DNA binding, SUMO polymer binding, identical protein binding, metal ion binding, nucleosome binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: PML body, cytoplasm, microtubule end, nuclear body, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Androgen receptor signaling pathway, AndrogenReceptor, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Immune System, Processing of DNA double-strand break ends
UniProt: P78317
Entrez ID: 6047
|
Does Knockout of FHDC1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
FHDC1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: FHDC1 (FH2 domain containing 1)
Type: protein-coding
Summary: Predicted to enable actin binding activity and microtubule binding activity. Involved in Golgi ribbon formation; cilium assembly; and stress fiber assembly. Located in cilium and microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Golgi ribbon formation, actin filament polymerization, cell projection organization, cilium assembly, stress fiber assembly; MF: actin binding, microtubule binding; CC: Golgi apparatus, actin filament, cell projection, cilium, cytoplasmic microtubule, microtubule
Pathways:
UniProt: Q9C0D6
Entrez ID: 85462
|
Does Knockout of PDCD4 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
PDCD4
|
cell proliferation
|
Cancer Cell Line
|
Gene: PDCD4 (programmed cell death 4)
Type: protein-coding
Summary: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: BMP signaling pathway, apoptotic process, cellular response to lipopolysaccharide, epithelial to mesenchymal transition involved in cardiac fibroblast development, negative regulation of DNA-templated transcription, negative regulation of JUN kinase activity, negative regulation of cytokine production involved in inflammatory response, negative regulation of myofibroblast differentiation, negative regulation of vascular associated smooth muscle cell differentiation, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of endothelial cell apoptotic process, positive regulation of inflammatory response, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of vascular associated smooth muscle cell apoptotic process; MF: RNA binding, protein binding; CC: cytoplasm, cytosol, nucleus
Pathways: Cytokine Signaling in Immune system, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Immune System, Interferon type I signaling pathways, Interleukin-12 family signaling, Interleukin-12 signaling, MicroRNAs in cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Signaling by Interleukins, Translation inhibitors in chronically activated PDGFRA cells, mTOR signaling pathway
UniProt: Q53EL6
Entrez ID: 27250
|
Does Knockout of SNX5 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 1
| 1,480
|
Knockout
|
SNX5
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: SNX5 (sorting nexin 5)
Type: protein-coding
Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: endocytosis, epidermal growth factor catabolic process, intracellular protein transport, negative regulation of blood pressure, pinocytosis, positive regulation of DNA-templated transcription, positive regulation of insulin receptor signaling pathway, protein transport, regulation of macroautophagy, retrograde transport, endosome to Golgi; MF: D1 dopamine receptor binding, cadherin binding, dynactin binding, lipid binding, phosphatidylinositol binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding, protein binding; CC: brush border, cell projection, cytoplasm, cytoplasmic side of early endosome membrane, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, early endosome, early endosome membrane, endosome, macropinocytic cup, membrane, perinuclear region of cytoplasm, phagocytic cup, plasma membrane, retromer complex, retromer, tubulation complex, ruffle, tubular endosome
Pathways: EGFR1, Endocytosis - Homo sapiens (human), Golgi Associated Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q9Y5X3
Entrez ID: 27131
|
Does Knockout of SEMA3F in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
SEMA3F
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SEMA3F (semaphorin 3F)
Type: protein-coding
Summary: This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: axon extension involved in axon guidance, axon guidance, branchiomotor neuron axon guidance, facial nerve structural organization, negative chemotaxis, negative regulation of axon extension involved in axon guidance, nerve development, neural crest cell migration, neural crest cell migration involved in autonomic nervous system development, positive regulation of cell migration, regulation of postsynapse organization, semaphorin-plexin signaling pathway, signal transduction, sympathetic ganglion development, sympathetic neuron projection extension, sympathetic neuron projection guidance, system development, trigeminal nerve structural organization, trunk neural crest cell migration, ventral trunk neural crest cell migration; MF: chemorepellent activity, neuropilin binding, semaphorin receptor binding, signaling receptor binding; CC: extracellular region, extracellular space, glutamatergic synapse, plasma membrane
Pathways: Axon guidance - Homo sapiens (human)
UniProt: Q13275
Entrez ID: 6405
|
Does Knockout of PLCD3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
PLCD3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PLCD3 (phospholipase C delta 3)
Type: protein-coding
Summary: This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: angiogenesis, intracellular signal transduction, labyrinthine layer blood vessel development, lipid catabolic process, lipid metabolic process, regulation of cell population proliferation, signal transduction; MF: hydrolase activity, metal ion binding, phosphatidylinositol-4,5-bisphosphate phospholipase C activity, phosphoric diester hydrolase activity; CC: cleavage furrow, cytoplasm, membrane, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Calcium signaling pathway - Homo sapiens (human), D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, D-<i>myo</i>-inositol-5-phosphate metabolism, GPR40 Pathway, Inositol Metabolism, Inositol phosphate metabolism, Inositol phosphate metabolism - Homo sapiens (human), Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Resistin as a regulator of inflammation, Shigellosis - Homo sapiens (human), Synthesis of IP3 and IP4 in the cytosol, Thyroid hormone signaling pathway - Homo sapiens (human), phospholipases, superpathway of inositol phosphate compounds
UniProt: Q8N3E9
Entrez ID: 113026
|
Does Knockout of XPO1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
XPO1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: XPO1 (exportin 1)
Type: protein-coding
Summary: This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: cellular response to salt, cellular response to triglyceride, intracellular protein transport, mRNA export from nucleus, mRNA transport, negative regulation of transcription by RNA polymerase II, nucleocytoplasmic transport, protein export from nucleus, protein localization to nucleus, protein transport, regulation of centrosome duplication, regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of protein catabolic process, regulation of protein export from nucleus, response to xenobiotic stimulus, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus, ribosomal subunit export from nucleus, ribosome biogenesis; MF: DNA-binding transcription factor binding, RNA binding, nuclear export signal receptor activity, protein binding, protein domain specific binding, small GTPase binding; CC: Cajal body, annulate lamellae, cytoplasm, cytosol, kinetochore, membrane, nuclear envelope, nuclear membrane, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex
Pathways: 22q11.2 copy number variation syndrome, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Canonical NF-kappaB pathway, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Cyclin A/B1/B2 associated events during G2/M transition, Deactivation of the beta-catenin transactivating complex, Developmental Biology, Disease, Downregulation of TGF-beta receptor signaling, EML4 and NUDC in mitotic spindle formation, ESR-mediated signaling, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Export of Viral Ribonucleoproteins from Nucleus, Extra-nuclear estrogen signaling, Fibroblast growth factor-1, FoxO family signaling, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, Hedgehog signaling events mediated by Gli proteins, Heme signaling, Host Interactions of HIV factors, HuR (ELAVL1) binds and stabilizes mRNA, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Infectious disease, Influenza A - Homo sapiens (human), Influenza Infection, Integrin-linked kinase signaling, Interactions of Rev with host cellular proteins, Late Phase of HIV Life Cycle, M Phase, MAPK family signaling cascades, MAPK6/MAPK4 signaling, MITF-M-regulated melanocyte development, Maturation of hRSV A proteins, Metabolism of RNA, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, NEP/NS2 Interacts with the Cellular Export Machinery, NPAS4 regulates expression of target genes, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, RNA transport - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of nuclear beta catenin signaling and target gene transcription, Resolution of Sister Chromatid Cohesion, Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) genome replication, transcription and translation, Rev-mediated nuclear export of HIV RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Role of Calcineurin-dependent NFAT signaling in lymphocytes, Separation of Sister Chromatids, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TCF dependent signaling in response to WNT, TGF-beta receptor signaling activates SMADs, TGF_beta_Receptor, Transcriptional Regulation by NPAS4, Transcriptional and post-translational regulation of MITF-M expression and activity, Viral Infection Pathways, eIF5A regulation in response to inhibition of the nuclear export system, regulation of spermatogenesis by crem, sonic hedgehog receptor ptc1 regulates cell cycle
UniProt: O14980
Entrez ID: 7514
|
Does Activation of MAGEC3 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
MAGEC3
|
response to virus
|
Hepatoma Cell Line
|
Gene: MAGEC3 (MAGE family member C3)
Type: protein-coding
Summary: This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosome Xq26-q27. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways:
UniProt: Q8TD91
Entrez ID: 139081
|
Does Knockout of MAGEF1 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
MAGEF1
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: MAGEF1 (MAGE family member F1)
Type: protein-coding
Summary: This intronless gene encodes a member of the MAGE superfamily. It is ubiquitously expressed in normal tissues and in tumor cells. This gene includes a microsatellite repeat in the coding region. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: negative regulation of double-strand break repair via homologous recombination, negative regulation of transcription by RNA polymerase II, protein ubiquitination, regulation of macromolecule metabolic process, regulation of primary metabolic process, ubiquitin-dependent protein catabolic process
Pathways:
UniProt: Q9HAY2
Entrez ID: 64110
|
Does Knockout of CST3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
CST3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CST3 (cystatin C)
Type: protein-coding
Summary: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: defense response, immune response, negative regulation of blood vessel remodeling, negative regulation of collagen catabolic process, negative regulation of elastin catabolic process, negative regulation of extracellular matrix disassembly, negative regulation of proteolysis, regulation of tissue remodeling, supramolecular fiber organization; MF: amyloid-beta binding, cysteine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, identical protein binding, peptidase inhibitor activity, protease binding, protein binding; CC: Golgi apparatus, cytoplasm, endoplasmic reticulum, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, plasma membrane, tertiary granule lumen, vesicle
Pathways: Amyloid fiber formation, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Salivary secretion - Homo sapiens (human)
UniProt: P01034
Entrez ID: 1471
|
Does Knockout of VCP in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
VCP
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: VCP (valosin containing protein)
Type: protein-coding
Summary: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: ATP metabolic process, DNA damage response, DNA repair, ERAD pathway, NAD+ metabolic process, aggresome assembly, autophagosome maturation, autophagy, canonical NF-kappaB signal transduction, cellular response to arsenite ion, cellular response to heat, cellular response to misfolded protein, cytoplasm protein quality control, double-strand break repair, endoplasmic reticulum stress-induced pre-emptive quality control, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum unfolded protein response, endosome to lysosome transport via multivesicular body sorting pathway, establishment of protein localization, flavin adenine dinucleotide catabolic process, interstrand cross-link repair, macroautophagy, mitotic spindle disassembly, negative regulation of hippo signaling, negative regulation of protein localization to chromatin, negative regulation of smoothened signaling pathway, positive regulation of ATP biosynthetic process, positive regulation of canonical Wnt signaling pathway, positive regulation of mitochondrial membrane potential, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of oxidative phosphorylation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K63-linked deubiquitination, positive regulation of protein catabolic process, positive regulation of protein-containing complex assembly, positive regulation of ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, protein-DNA covalent cross-linking repair, regulation of aerobic respiration, regulation of apoptotic process, regulation of protein localization to chromatin, regulation of synapse organization, retrograde protein transport, ER to cytosol, stress granule disassembly, translesion synthesis, ubiquitin-dependent protein catabolic process, viral genome replication; MF: ADP binding, ATP binding, ATP hydrolysis activity, BAT3 complex binding, K48-linked polyubiquitin modification-dependent protein binding, MHC class I protein binding, RNA binding, deubiquitinase activator activity, hydrolase activity, identical protein binding, lipid binding, nucleotide binding, polyubiquitin modification-dependent protein binding, protein binding, protein domain specific binding, protein phosphatase binding, protein-containing complex binding, ubiquitin protein ligase binding, ubiquitin-like protein ligase binding, ubiquitin-modified protein reader activity, ubiquitin-specific protease binding; CC: ATPase complex, Derlin-1 retrotranslocation complex, VCP-NPL4-UFD1 AAA ATPase complex, VCP-NSFL1C complex, azurophil granule lumen, ciliary basal body, cytoplasm, cytoplasmic stress granule, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, glutamatergic synapse, intracellular membrane-bounded organelle, lipid droplet, nucleoplasm, nucleus, perinuclear region of cytoplasm, proteasome complex, protein-containing complex, secretory granule lumen, site of double-strand break, synapse
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Aggrephagy, Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, Attachment and Entry, Autophagy, Cellular response to chemical stress, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Co-inhibition by PD-1, DNA Damage Bypass, DNA Repair, Defective CFTR causes cystic fibrosis, Deubiquitination, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, E3 ubiquitin ligases ubiquitinate target proteins, Early SARS-CoV-2 Infection Events, HSF1 activation, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Immune System, Infectious disease, Innate Immune System, Josephin domain DUBs, KEAP1-NFE2L2 pathway, Legionellosis - Homo sapiens (human), Macroautophagy, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Neddylation, Neutrophil degranulation, Ovarian tumor domain proteases, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Protein methylation, Protein processing in endoplasmic reticulum - Homo sapiens (human), Protein ubiquitination, RHO GTPase cycle, RHOH GTPase cycle, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Selective autophagy, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Translation, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Transport of small molecules, Viral Infection Pathways
UniProt: P55072
Entrez ID: 7415
|
Does Knockout of TNNI1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
TNNI1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: TNNI1 (troponin I1, slow skeletal type)
Type: protein-coding
Summary: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cardiac muscle contraction, regulation of striated muscle contraction, skeletal muscle contraction, transition between fast and slow fiber, ventricular cardiac muscle tissue morphogenesis; MF: actin binding, protein binding; CC: cytosol, troponin complex
Pathways: Acebutolol Action Pathway, Alprenolol Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupranolol Action Pathway, Carteolol Action Pathway, Carvedilol Action Pathway, Diltiazem Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Epinephrine Action Pathway, Esmolol Action Pathway, Felodipine Action Pathway, Flecainide Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, Ibutilide Action Pathway, Isoprenaline Action Pathway, Isradipine Action Pathway, Labetalol Action Pathway, Levobunolol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Muscle contraction, Muscle/Heart Contraction, Nadolol Action Pathway, Nebivolol Action Pathway, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Penbutolol Action Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Practolol Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Sotalol Action Pathway, Striated Muscle Contraction, Striated Muscle Contraction Pathway, Timolol Action Pathway, Tocainide Action Pathway, Verapamil Action Pathway, actions of nitric oxide in the heart
UniProt: P19237
Entrez ID: 7135
|
Does Knockout of MTPAP in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
MTPAP
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MTPAP (mitochondrial poly(A) polymerase)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011].
Gene Ontology: BP: RNA 3'-end processing, histone mRNA catabolic process, mRNA processing, mitochondrial RNA 3'-end processing, mitochondrial mRNA polyadenylation; MF: ATP binding, RNA binding, UTP binding, identical protein binding, magnesium ion binding, manganese ion binding, metal ion binding, nucleotide binding, nucleotidyltransferase activity, poly(A) RNA polymerase activity, protein binding, protein homodimerization activity, transferase activity; CC: cytoplasm, mitochondrion, nucleoplasm
Pathways: Metabolism of RNA, Mitochondrial mRNA modification
UniProt: Q9NVV4
Entrez ID: 55149
|
Does Knockout of SERPING1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
SERPING1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SERPING1 (serpin family G member 1)
Type: protein-coding
Summary: This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, May 2020].
Gene Ontology: BP: blood circulation, blood coagulation, fibrinolysis, hemostasis, negative regulation of complement activation, lectin pathway; MF: peptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity; CC: blood microparticle, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix, extracellular region, extracellular space, platelet alpha granule lumen
Pathways: Complement and Coagulation Cascades, Complement and coagulation cascades - Homo sapiens (human), Complement cascade, Complement system, Defective SERPING1 causes hereditary angioedema, Defects of contact activation system (CAS) and kallikrein/kinin system (KKS), Disease, Diseases of hemostasis, Formation of Fibrin Clot (Clotting Cascade), Hemostasis, Immune System, Innate Immune System, Intrinsic Pathway of Fibrin Clot Formation, Pertussis - Homo sapiens (human), Platelet activation, signaling and aggregation, Platelet degranulation , RAS and bradykinin pathways in COVID-19, Regulation of Complement cascade, Response to elevated platelet cytosolic Ca2+, intrinsic prothrombin activation pathway
UniProt: P05155
Entrez ID: 710
|
Does Knockout of COG3 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
COG3
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: COG3 (component of oligomeric golgi complex 3)
Type: protein-coding
Summary: This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011].
Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, glycosylation, intra-Golgi vesicle-mediated transport, intracellular protein transport, protein glycosylation, protein localization to organelle, protein stabilization, protein transport, retrograde transport, vesicle recycling within Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, Golgi transport complex, cis-Golgi network, cytosol, membrane, plasma membrane, trans-Golgi network membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q96JB2
Entrez ID: 83548
|
Does Knockout of TANC1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
TANC1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1)
Type: protein-coding
Summary: Predicted to be involved in regulation of postsynapse organization. Predicted to act upstream of or within dendritic spine maintenance; myoblast fusion; and visual learning. Predicted to be located in several cellular components, including axon terminus; neuronal cell body; and postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: dendritic spine maintenance, myoblast fusion, regulation of postsynapse organization, visual learning; CC: axon terminus, dendrite, glutamatergic synapse, neuronal cell body, postsynaptic density, synapse
Pathways:
UniProt: Q9C0D5
Entrez ID: 85461
|
Does Knockout of CERS5 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
CERS5
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: CERS5 (ceramide synthase 5)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: ceramide biosynthetic process, lipid metabolic process, oligodendrocyte development, sphingolipid biosynthetic process, sphingolipid metabolic process; MF: DNA binding, sphingosine N-acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Metabolism, Metabolism of lipids, Sphingolipid Metabolism (integrated pathway), Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Homo sapiens (human), Sphingolipid pathway, Sphingolipid signaling pathway - Homo sapiens (human)
UniProt: Q8N5B7
Entrez ID: 91012
|
Does Knockout of EIF2B3 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
EIF2B3
|
cell proliferation
|
Bladder Carcinoma
|
Gene: EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)
Type: protein-coding
Summary: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: T cell receptor signaling pathway, central nervous system development, cytoplasmic translational initiation, oligodendrocyte development, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, protein binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Translation, Translation Factors
UniProt: Q9NR50
Entrez ID: 8891
|
Does Knockout of PIK3R4 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
PIK3R4
|
response to virus
|
Lung Cancer Cell Line
|
Gene: PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4)
Type: protein-coding
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of phosphatidylinositol 3-kinase activity; receptor catabolic process; and regulation of cytokinesis. Located in late endosome and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagosome maturation, cellular response to glucose starvation, early endosome to late endosome transport, late endosome to vacuole transport, macroautophagy, pexophagy, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol-3-phosphate biosynthetic process, protein phosphorylation, protein targeting to lysosome, protein targeting to vacuole, receptor catabolic process, regulation of autophagy, regulation of cytokinesis, regulation of macroautophagy; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: autophagosome, axoneme, ciliary basal body, cilium, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endosome, intercellular bridge, late endosome, membrane, microtubule cytoskeleton, nucleus-vacuole junction, phagocytic vesicle membrane, phosphatidylinositol 3-kinase complex, class III, phosphatidylinositol 3-kinase complex, class III, type I, phosphatidylinositol 3-kinase complex, class III, type II
Pathways: 3-phosphoinositide biosynthesis, Adaptive Immune System, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Angiopoietin Like Protein 8 Regulatory Pathway, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Apelin signaling pathway - Homo sapiens (human), Autophagy, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), Ciliopathies, Class I MHC mediated antigen processing & presentation, DNA damage response (only ATM dependent), Disease, Early SARS-CoV-2 Infection Events, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Huntington disease - Homo sapiens (human), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Infectious disease, Innate Immune System, Inositol Metabolism, Insulin Signaling, Insulin receptor signalling cascade, Joubert syndrome, Macroautophagy, Metabolism, Metabolism of lipids, Neural Crest Cell Migration during Development, Neural Crest Cell Migration in Cancer, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Osteoblast differentiation, PI Metabolism, PI3K Cascade, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phosphatidylinositol Phosphate Metabolism, Phospholipid metabolism, RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, Regulation of Actin Cytoskeleton, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Spinocerebellar ataxia - Homo sapiens (human), Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Translation of Replicase and Assembly of the Replication Transcription Complex, Viral Infection Pathways, superpathway of inositol phosphate compounds
UniProt: Q99570
Entrez ID: 30849
|
Does Knockout of ABO in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
ABO
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase)
Type: protein-coding
Summary: This gene encodes proteins related to the first discovered blood group system, ABO. Variation in the ABO gene (chromosome 9q34.2) is the basis of the ABO blood group, thus the presence of an allele determines the blood group in an individual. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. [provided by RefSeq, Apr 2022].
Gene Ontology: BP: carbohydrate metabolic process, protein glycosylation; MF: antigen binding, fucosylgalactoside 3-alpha-galactosyltransferase activity, glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, manganese ion binding, metal ion binding, nucleotide binding, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, extracellular region, membrane, vesicle
Pathways: ABO blood group biosynthesis, Blood group systems biosynthesis, Globo Sphingolipid Metabolism, Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: P16442
Entrez ID: 28
|
Does Knockout of CXCL14 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
CXCL14
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: CXCL14 (C-X-C motif chemokine ligand 14)
Type: protein-coding
Summary: This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cell chemotaxis, cell-cell signaling, chemotaxis, immune response, killing of cells of another organism, signal transduction; MF: chemokine activity, cytokine activity, protein binding; CC: Golgi apparatus, extracellular region, extracellular space
Pathways: Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Cytokine-cytokine receptor interaction - Homo sapiens (human), Senescence and Autophagy in Cancer, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: O95715
Entrez ID: 9547
|
Does Knockout of INO80D in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
INO80D
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: INO80D (INO80 complex subunit D)
Type: protein-coding
Summary: Predicted to be involved in DNA recombination and DNA repair. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin remodeling, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of telomere maintenance in response to DNA damage, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, telomere maintenance; CC: Ino80 complex, nucleoplasm, nucleus
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Gastric Cancer Network 1, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q53TQ3
Entrez ID: 54891
|
Does Knockout of TVP23C in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
TVP23C
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: TVP23C (trans-golgi network vesicle protein 23 homolog C)
Type: protein-coding
Summary: Predicted to be involved in protein secretion and vesicle-mediated transport. Predicted to be integral component of membrane. Predicted to be integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein secretion, vesicle-mediated transport; CC: Golgi membrane, membrane
Pathways:
UniProt: Q96ET8
Entrez ID: 201158
|
Does Knockout of USP37 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
USP37
|
cell proliferation
|
Bladder Carcinoma
|
Gene: USP37 (ubiquitin specific peptidase 37)
Type: protein-coding
Summary: Enables cysteine-type endopeptidase activity; protein kinase binding activity; and thiol-dependent deubiquitinase. Involved in G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of DNA replication. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, protein K11-linked deubiquitination, protein K48-linked deubiquitination, protein deubiquitination, proteolysis, regulation of DNA replication, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, peptidase activity, protein binding, protein kinase binding; CC: chromosome, cytosol, nucleoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q86T82
Entrez ID: 57695
|
Does Knockout of LPAR5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
LPAR5
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: LPAR5 (lysophosphatidic acid receptor 5)
Type: protein-coding
Summary: This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, behavioral response to pain, signal transduction; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Lysosphingolipid and LPA receptors, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Regulation of actin cytoskeleton - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q9H1C0
Entrez ID: 57121
|
Does Knockout of ENTPD4 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
ENTPD4
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)
Type: protein-coding
Summary: This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: CTP metabolic process, GDP catabolic process, UDP catabolic process, nucleobase-containing small molecule catabolic process, purine ribonucleotide metabolic process, pyrimidine ribonucleotide catabolic process; MF: CDP phosphatase activity, CTPase activity, GDP phosphatase activity, GTPase activity, UDP phosphatase activity, hydrolase activity, nucleoside diphosphate phosphatase activity, protein binding, ribonucleoside triphosphate phosphatase activity; CC: Golgi apparatus, Golgi membrane, autophagosome membrane, cytoplasmic vesicle, lysosomal membrane, lysosome, membrane
Pathways: Lysosome - Homo sapiens (human), Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Phosphate bond hydrolysis by NTPDase proteins, Purine metabolism - Homo sapiens (human), Pyrimidine metabolism - Homo sapiens (human)
UniProt: Q9Y227
Entrez ID: 9583
|
Does Knockout of UBE2I in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
UBE2I
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: UBE2I (ubiquitin conjugating enzyme E2 I)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell division, chromosome segregation, mitotic nuclear membrane reassembly, modulation of chemical synaptic transmission, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, nuclear export, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, protein modification process, protein sumoylation, ubiquitin-dependent protein catabolic process; MF: ATP binding, HLH domain binding, RING-like zinc finger domain binding, RNA binding, SUMO conjugating enzyme activity, SUMO transferase activity, enzyme binding, nucleotide binding, protein binding, small protein activating enzyme binding, transcription coregulator binding, transcription factor binding, transferase activity; CC: PML body, SUMO ligase complex, Schaffer collateral - CA1 synapse, cytoplasm, cytosol, glutamatergic synapse, nuclear body, nuclear envelope, nuclear pore, nucleoplasm, nucleus, perinuclear region of cytoplasm, postsynaptic cytosol, presynaptic cytosol, synaptonemal complex, transferase complex
Pathways: Androgen receptor signaling pathway, AndrogenReceptor, Antiviral mechanism by IFN-stimulated genes, C-MYB transcription factor network, Cell Cycle, Cell Cycle, Mitotic, Coregulation of Androgen receptor activity, Cytokine Signaling in Immune system, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Developmental Biology, Disease, Epigenetic regulation of gene expression, Formation of Incision Complex in GG-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Immune System, Infectious disease, Interferon Signaling, Late SARS-CoV-2 Infection Events, M Phase, MITF-M-regulated melanocyte development, Maturation of nucleoprotein, Meiosis, Meiotic synapsis, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, MicroRNAs in cancer - Homo sapiens (human), Mitotic Anaphase, Mitotic Metaphase and Anaphase, NF-kappa B signaling pathway - Homo sapiens (human), Negative regulation of activity of TFAP2 (AP-2) family transcription factors, Nuclear Envelope (NE) Reassembly, Nucleotide Excision Repair, PKR-mediated signaling, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing and activation of SUMO, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, RNA transport - Homo sapiens (human), Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of cytoplasmic and nuclear SMAD2/3 signaling, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins, Reproduction, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 targets host intracellular signalling and regulatory pathways, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SUMO E3 ligases SUMOylate target proteins, SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA methylation proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of immune response proteins, SUMOylation of intracellular receptors, SUMOylation of nuclear envelope proteins, SUMOylation of transcription cofactors, SUMOylation of transcription factors, SUMOylation of ubiquitinylation proteins, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TGF-beta Signaling Pathway, TGF_beta_Receptor, TNFalpha, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Translation of Structural Proteins, Ubiquitin mediated proteolysis - Homo sapiens (human), Viral Infection Pathways, Vitamin D (calciferol) metabolism, basic mechanisms of sumoylation, er associated degradation (erad) pathway, regulation of transcriptional activity by pml
UniProt: P63279
Entrez ID: 7329
|
Does Knockout of SYNJ2BP in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
SYNJ2BP
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: SYNJ2BP (synaptojanin 2 binding protein)
Type: protein-coding
Summary: Predicted to enable type II activin receptor binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of sprouting angiogenesis; and regulation of signal transduction. Located in mitochondrion. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Rho protein signal transduction, negative regulation of ERK1 and ERK2 cascade, negative regulation of angiogenesis, negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, negative regulation of sprouting angiogenesis, protein targeting, regulation of Notch signaling pathway, regulation of endocytosis; CC: membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: P57105
Entrez ID: 55333
|
Does Knockout of GINS4 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
GINS4
|
cell proliferation
|
T-lymphoma cell line
|
Gene: GINS4 (GINS complex subunit 4)
Type: protein-coding
Summary: The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008].
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, double-strand break repair via break-induced replication, inner cell mass cell proliferation; CC: CMG complex, GINS complex, chromosome, cytoplasm, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA strand elongation, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: Q9BRT9
Entrez ID: 84296
|
Does Knockout of DEFB105B in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
DEFB105B
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: DEFB105B (defensin beta 105B)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105B, represents the more telomeric copy. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: defense response, defense response to bacterium, innate immune response
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q8NG35
Entrez ID: 504180
|
Does Knockout of LIAS in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
LIAS
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: LIAS (lipoic acid synthetase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant. The deficient expression of this enzyme has been linked to conditions such as diabetes, atherosclerosis and neonatal-onset epilepsy. Alternative splicing occurs at this locus, and several transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: inflammatory response, lipoate biosynthetic process, neural tube closure, protein lipoylation, response to lipopolysaccharide, response to oxidative stress; MF: 4 iron, 4 sulfur cluster binding, catalytic activity, iron-sulfur cluster binding, lipoate synthase activity, metal ion binding, sulfurtransferase activity, transferase activity; CC: mitochondrial matrix, mitochondrion
Pathways: Lipoic acid metabolism - Homo sapiens (human), Metabolism of proteins, Post-translational protein modification, Protein lipoylation, lipoate biosynthesis and incorporation
UniProt: O43766
Entrez ID: 11019
|
Does Knockout of ZC3H4 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
ZC3H4
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: ZC3H4 (zinc finger CCCH-type containing 4)
Type: protein-coding
Summary: This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: DNA-templated transcription termination, lncRNA catabolic process, negative regulation of DNA-templated transcription, negative regulation of DNA-templated transcription, elongation, negative regulation of lncRNA transcription, nuclear RNA surveillance; MF: RNA binding, chromatin binding, metal ion binding, promoter-specific chromatin binding, protein binding, zinc ion binding; CC: chromosome, cytosol, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Nuclear RNA decay
UniProt: Q9UPT8
Entrez ID: 23211
|
Does Knockout of ZBTB17 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
ZBTB17
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ZBTB17 (zinc finger and BTB domain containing 17)
Type: protein-coding
Summary: This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G1 to G0 transition, ectoderm development, gastrulation with mouth forming second, negative regulation of cell cycle, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, core promoter sequence-specific DNA binding, metal ion binding, protein binding, transcription coactivator binding, zinc ion binding; CC: nucleoplasm, nucleus, protein-DNA complex, protein-containing complex
Pathways: C-MYC pathway, Cell cycle, Cell cycle - Homo sapiens (human), Cellular responses to stimuli, Cellular responses to stress, IRE1alpha activates chaperones, Pathways in cancer - Homo sapiens (human), Regulation of nuclear SMAD2/3 signaling, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), TNFalpha, Transcriptional misregulation in cancer - Homo sapiens (human), Unfolded Protein Response (UPR), Validated targets of C-MYC transcriptional repression, XBP1(S) activates chaperone genes
UniProt: Q13105
Entrez ID: 7709
|
Does Knockout of GTF3C4 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
GTF3C4
|
cell proliferation
|
T-lymphoma cell line
|
Gene: GTF3C4 (general transcription factor IIIC subunit 4)
Type: protein-coding
Summary: Predicted to enable enzyme activator activity. Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and tRNA transcription by RNA polymerase III. Located in mitochondrion and nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 5S class rRNA transcription by RNA polymerase III, chromatin remodeling, tRNA transcription by RNA polymerase III, transcription by RNA polymerase III, transcription initiation at RNA polymerase III promoter; MF: DNA binding, RNA polymerase III general transcription initiation factor activity, acyltransferase activity, histone H3K14 acetyltransferase activity, histone acetyltransferase activity, protein binding, protein-lysine-acetyltransferase activity, transferase activity; CC: mitochondrion, nucleoplasm, nucleus, transcription factor TFIIIC complex
Pathways: Gene expression (Transcription), RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, rna polymerase iii transcription
UniProt: Q9UKN8
Entrez ID: 9329
|
Does Knockout of HDLBP in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
HDLBP
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: HDLBP (high density lipoprotein binding protein)
Type: protein-coding
Summary: The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: cholesterol metabolic process, lipid metabolic process, lipid transport, steroid metabolic process; MF: RNA binding, cadherin binding, lipid binding, mRNA binding, nucleic acid binding, protein binding; CC: cytoplasm, high-density lipoprotein particle, nucleus, plasma membrane
Pathways: HDL clearance, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Transport of small molecules
UniProt: Q00341
Entrez ID: 3069
|
Does Knockout of CLIC5 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
CLIC5
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: CLIC5 (chloride intracellular channel 5)
Type: protein-coding
Summary: This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: chloride transmembrane transport, chloride transport, female pregnancy, monoatomic ion transmembrane transport, monoatomic ion transport, sensory perception of sound, visual perception; MF: chloride channel activity, oxidoreductase activity, protein binding; CC: Golgi apparatus, actin cytoskeleton, apical plasma membrane, cell cortex, cell projection, centrosome, chloride channel complex, cytoplasm, cytoskeleton, extracellular exosome, membrane, mitochondrion, monoatomic ion channel complex, plasma membrane, stereocilium
Pathways: Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea
UniProt: Q9NZA1
Entrez ID: 53405
|
Does Knockout of USP32 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
USP32
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: USP32 (ubiquitin specific peptidase 32)
Type: protein-coding
Summary: Enables thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of TORC1 signaling, protein deubiquitination, proteolysis; MF: calcium ion binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, protein binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endomembrane system, membrane
Pathways:
UniProt: Q8NFA0
Entrez ID: 84669
|
Does Knockout of TECPR1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
TECPR1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: TECPR1 (tectonin beta-propeller repeat containing 1)
Type: protein-coding
Summary: This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012].
Gene Ontology: BP: autophagosome maturation, autophagy, macroautophagy, regulation of autophagosome maturation; MF: lipid binding, phosphatidylinositol-3-phosphate binding, protein binding; CC: autophagosome membrane, bounding membrane of organelle, cytoplasm, cytoplasmic vesicle, lysosomal membrane, lysosome, membrane, nucleoplasm, protein-containing complex
Pathways: Shigellosis - Homo sapiens (human)
UniProt: Q7Z6L1
Entrez ID: 25851
|
Does Knockout of NACA in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
NACA
|
cell proliferation
|
T-lymphoma cell line
|
Gene: NACA (nascent polypeptide associated complex subunit alpha)
Type: protein-coding
Summary: This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cardiac ventricle development, heart trabecula morphogenesis, negative regulation of protein localization to endoplasmic reticulum, negative regulation of striated muscle cell apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of cell proliferation involved in heart morphogenesis, positive regulation of skeletal muscle tissue growth, positive regulation of transcription by RNA polymerase II, protein targeting to membrane, protein transport, regulation of skeletal muscle fiber development, skeletal muscle tissue regeneration, translation, wound healing; MF: DNA binding, protein binding, transcription coactivator activity, unfolded protein binding; CC: cytoplasm, extracellular exosome, nascent polypeptide-associated complex, nucleus
Pathways: IL-18 signaling pathway, Integrin-linked kinase signaling, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
UniProt: Q13765, E9PAV3
Entrez ID: 4666
|
Does Knockout of ACP1 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
ACP1
|
response to virus
|
Lung Cancer Cell Line
|
Gene: ACP1 (acid phosphatase 1)
Type: protein-coding
Summary: The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008].
Gene Ontology: MF: SH3 domain binding, acid phosphatase activity, hydrolase activity, non-membrane spanning protein tyrosine phosphatase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein tyrosine phosphatase activity; CC: cytoplasm, cytoplasmic side of plasma membrane, cytosol, extracellular exosome, sarcolemma, synapse
Pathways: Adherens junction - Homo sapiens (human), EGFR1, EPHA2 forward signaling, Riboflavin Metabolism, Riboflavin metabolism - Homo sapiens (human), TCR, Thiamine metabolism - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway
UniProt: P24666
Entrez ID: 52
|
Does Knockout of RALB in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
RALB
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RALB (RAS like proto-oncogene B)
Type: protein-coding
Summary: This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Ras protein signal transduction, apoptotic process, cell division, positive regulation of autophagosome assembly, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of innate immune response, receptor internalization, regulation of exocyst assembly, regulation of exocyst localization, signal transduction; MF: ATPase binding, G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding, ubiquitin protein ligase binding; CC: extracellular exosome, membrane, midbody, plasma membrane
Pathways: CXCR4-mediated signaling events, Chromosomal and microsatellite instability in colorectal cancer, Ciliary landscape, Colorectal cancer - Homo sapiens (human), EGF-EGFR signaling pathway, EGFR1, FoxO family signaling, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of p38-alpha and p38-beta, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signalling to ERKs, Signalling to RAS, p38MAPK events
UniProt: P11234
Entrez ID: 5899
|
Does Knockout of NDUFS2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
NDUFS2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)
Type: protein-coding
Summary: The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: aerobic respiration, cellular response to oxygen levels, gliogenesis, mitochondrial ATP synthesis coupled electron transport, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, neural precursor cell proliferation, neurogenesis, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: 4 iron, 4 sulfur cluster binding, NAD binding, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, electron transfer activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, oxygen sensor activity, protein binding, quinone binding, ubiquitin protein ligase binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Doxorubicin Metabolism Pathway, Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human), p73 transcription factor network
UniProt: O75306
Entrez ID: 4720
|
Does Knockout of MED11 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
MED11
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: MED11 (mediator complex subunit 11)
Type: protein-coding
Summary: MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II; MF: protein binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Infectious disease, Metabolism, Metabolism of lipids, PPARA activates gene expression, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9P086
Entrez ID: 400569
|
Does Knockout of HSP90AB1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
HSP90AB1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: HSP90AB1 (heat shock protein 90 alpha family class B member 1)
Type: protein-coding
Summary: This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: cellular response to heat, cellular response to interleukin-4, chaperone-mediated protein complex assembly, negative regulation of apoptotic process, negative regulation of proteasomal protein catabolic process, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, placenta development, positive regulation of cell differentiation, positive regulation of nitric oxide biosynthetic process, positive regulation of protein localization to cell surface, positive regulation of transforming growth factor beta receptor signaling pathway, protein folding, protein stabilization, regulation of cell cycle, regulation of protein localization, regulation of protein ubiquitination, response to unfolded protein, supramolecular fiber organization, telomerase holoenzyme complex assembly, telomere maintenance via telomerase, virion attachment to host cell; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein binding, ATP-dependent protein folding chaperone, DNA polymerase binding, MHC class II protein complex binding, RNA binding, TPR domain binding, cadherin binding, disordered domain specific binding, double-stranded RNA binding, heat shock protein binding, histone deacetylase binding, histone methyltransferase binding, identical protein binding, kinase binding, nitric-oxide synthase regulator activity, nucleotide binding, peptide binding, protein binding, protein dimerization activity, protein folding chaperone, protein homodimerization activity, protein kinase binding, protein kinase regulator activity, protein phosphatase activator activity, receptor ligand inhibitor activity, tau protein binding, ubiquitin protein ligase binding, unfolded protein binding; CC: COP9 signalosome, HSP90-CDC37 chaperone complex, aryl hydrocarbon receptor complex, axonal growth cone, cell surface, cytoplasm, cytosol, dendritic growth cone, dynein axonemal particle, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, melanosome, membrane, mitochondrion, neuronal cell body, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, protein folding chaperone complex, protein-containing complex, secretory granule lumen
Pathways: Antigen processing and presentation - Homo sapiens (human), Aryl hydrocarbon receptor signalling, Assembly and release of respiratory syncytial virus (RSV) virions, Attenuation phase, Autophagy, Axon guidance, Bacterial Infection Pathways, Biological oxidations, Cell Cycle, Cell Cycle, Mitotic, Cell recruitment (pro-inflammatory response), Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Chaperone Mediated Autophagy, DDX58/IFIH1-mediated induction of interferon-alpha/beta, Developmental Biology, Disease, ESR-mediated signaling, Estrogen signaling pathway - Homo sapiens (human), Estrogen-dependent gene expression, Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, G2/M Transition, HSF1 activation, HSF1-dependent transactivation, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, IL-17 signaling pathway - Homo sapiens (human), Immune System, Infectious disease, Inflammasomes, Innate Immune System, Leishmania infection, Lipid and atherosclerosis - Homo sapiens (human), Metabolism, Mitotic G2-G2/M phases, NOD-like receptor signaling pathway - Homo sapiens (human), NRF2 pathway, Necroptosis - Homo sapiens (human), Nervous system development, Neutrophil degranulation, Nuclear Receptors Meta-Pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parasitic Infection Pathways, Pathways in cancer - Homo sapiens (human), Phase I - Functionalization of compounds, Potential therapeutics for SARS, Progesterone-mediated oocyte maturation - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), Purinergic signaling in leishmaniasis infection, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, Regulation of actin dynamics for phagocytic cup formation, Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) genome replication, transcription and translation, Respiratory syncytial virus genome replication, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Salmonella infection - Homo sapiens (human), Sema3A PAK dependent Axon repulsion, Semaphorin interactions, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling events mediated by VEGFR1 and VEGFR2, TCR, TNFalpha, Th17 cell differentiation - Homo sapiens (human), The NLRP3 inflammasome, The role of GTSE1 in G2/M progression after G2 checkpoint, Uptake and actions of bacterial toxins, Uptake and function of diphtheria toxin, Viral Infection Pathways
UniProt: P08238
Entrez ID: 3326
|
Does Activation of CPO in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
CPO
|
protein/peptide accumulation
|
T cell
|
Gene: CPO (carboxypeptidase O)
Type: protein-coding
Summary: This gene is a member of the metallocarboxypeptidase gene family. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: proteolysis; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: apical plasma membrane, extracellular space, membrane, plasma membrane, side of membrane
Pathways:
UniProt: Q8IVL8
Entrez ID: 130749
|
Does Knockout of GAPDH in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
GAPDH
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: GAPDH (glyceraldehyde-3-phosphate dehydrogenase)
Type: protein-coding
Summary: This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, apoptotic process, cellular response to type II interferon, defense response to fungus, glucose metabolic process, glycolytic process, immune system process, innate immune response, killing by host of symbiont cells, killing of cells of another organism, microtubule cytoskeleton organization, negative regulation of endopeptidase activity, negative regulation of translation, neuron apoptotic process, peptidyl-cysteine S-trans-nitrosylation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cytokine production, positive regulation of type I interferon production, protein stabilization, regulation of macroautophagy, regulation of translation; MF: NAD binding, NADP binding, aspartic-type endopeptidase inhibitor activity, disordered domain specific binding, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, identical protein binding, microtubule binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, peptidyl-cysteine S-nitrosylase activity, protein binding, transferase activity; CC: GAIT complex, cytoplasm, cytoskeleton, cytosol, extracellular exosome, lipid droplet, membrane, microtubule cytoskeleton, nuclear membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, ribonucleoprotein complex, vesicle
Pathways: Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Computational Model of Aerobic Glycolysis, Cori Cycle, Diabetic cardiomyopathy - Homo sapiens (human), Fanconi-bickel syndrome, Fructose-1,6-diphosphatase deficiency, Gluconeogenesis, Glucose metabolism, Glycerol Phosphate Shuttle, Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycogenosis, Type VII. Tarui disease, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, Glycolysis in senescence, HIF-1 signaling pathway - Homo sapiens (human), HIF1A and PPARG regulation of glycolysis, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Mitochondrial Electron Transport Chain, NADH repair, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways in clear cell renal cell carcinoma, Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Salmonella infection - Homo sapiens (human), Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Triosephosphate isomerase, VEGFA-VEGFR2 Signaling Pathway, Validated targets of C-MYC transcriptional activation, Warburg Effect, downregulated of mta-3 in er-negative breast tumors, gluconeogenesis, glycolysis, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P04406
Entrez ID: 2597
|
Does Knockout of TXN2 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
TXN2
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: TXN2 (thioredoxin 2)
Type: protein-coding
Summary: This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: protein binding, protein-disulfide reductase activity; CC: mitochondrial matrix, mitochondrion, nucleolus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Degradation of cysteine and homocysteine, Detoxification of Reactive Oxygen Species, Fluid shear stress and atherosclerosis - Homo sapiens (human), Metabolism, Metabolism of amino acids and derivatives, NOD-like receptor signaling pathway - Homo sapiens (human), Oxidative Stress, Parkinson disease - Homo sapiens (human), Salmonella infection - Homo sapiens (human), Sulfur amino acid metabolism
UniProt: Q99757
Entrez ID: 25828
|
Does Knockout of LINC01587 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
LINC01587
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: LINC01587 (long intergenic non-protein coding RNA 1587)
Type: ncRNA
Summary: This gene is expressed in neuroblastoma; however, the function of this gene is not yet determined. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 10141
|
Does Knockout of DARS2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,459
|
Knockout
|
DARS2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: DARS2 (aspartyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq, Nov 2009].
Gene Ontology: BP: aspartyl-tRNA aminoacylation, mitochondrial asparaginyl-tRNA aminoacylation, tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, aspartate-tRNA ligase activity, aspartate-tRNA(Asn) ligase activity, ligase activity, nucleic acid binding, nucleotide binding, protein binding, protein homodimerization activity, tRNA binding; CC: cytoplasm, membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Metabolism of proteins, Mitochondrial tRNA aminoacylation, Translation, tRNA Aminoacylation, tRNA charging
UniProt: Q6PI48
Entrez ID: 55157
|
Does Knockout of GOLGA8N in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
GOLGA8N
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: GOLGA8N (golgin A8 family member N)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Golgi apparatus, Golgi cis cisterna, Golgi cisterna membrane, cis-Golgi network
Pathways:
UniProt: F8WBI6
Entrez ID: 643699
|
Does Knockout of NAA25 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
NAA25
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit)
Type: protein-coding
Summary: This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010].
Gene Ontology: MF: acetyltransferase activator activity, protein binding; CC: Golgi apparatus, NatB complex, cytoplasm, cytosol
Pathways:
UniProt: Q14CX7
Entrez ID: 80018
|
Does Knockout of NIFK in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
NIFK
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: NIFK (nucleolar protein interacting with the FHA domain of MKI67)
Type: protein-coding
Summary: This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009].
Gene Ontology: BP: protein-containing complex assembly, rRNA metabolic process, rRNA transcription; MF: RNA binding, nucleic acid binding, protein binding; CC: chromosome, condensed nuclear chromosome, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9BYG3
Entrez ID: 84365
|
Does Knockout of DEPTOR in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
DEPTOR
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: DEPTOR (DEP domain containing MTOR interacting protein)
Type: protein-coding
Summary: Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, TORC1 signaling, autophagosome assembly, cellular response to nutrient levels, intracellular signal transduction, negative regulation of TOR signaling, negative regulation of TORC1 signaling, negative regulation of TORC2 signaling, negative regulation of autophagy, negative regulation of cell size, negative regulation of protein kinase activity, positive regulation of autophagy, regulation of extrinsic apoptotic signaling pathway; MF: GTPase activator activity, guanyl-nucleotide exchange factor activity, lipid binding, phosphatidic acid binding, protein binding, protein kinase inhibitor activity, protein serine/threonine kinase inhibitor activity; CC: lysosomal membrane, lysosome, membrane, plasma membrane
Pathways: Autophagy, Autophagy - animal - Homo sapiens (human), Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Fragile X Syndrome, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Pathways in clear cell renal cell carcinoma, Regulatory circuits of the STAT3 signaling pathway, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), mTOR signaling pathway, mTOR signaling pathway - Homo sapiens (human)
UniProt: Q8TB45
Entrez ID: 64798
|
Does Knockout of VHLL in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
VHLL
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: VHLL (VHL like)
Type: protein-coding
Summary: Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010].
Gene Ontology:
Pathways:
UniProt: Q6RSH7
Entrez ID: 391104
|
Does Knockout of RBBP6 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
RBBP6
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: RBBP6 (RB binding protein 6, ubiquitin ligase)
Type: protein-coding
Summary: The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA replication, embryonic organ development, in utero embryonic development, mRNA processing, multicellular organism growth, protein ubiquitination, regulation of DNA replication, somite development, ubiquitin-dependent protein catabolic process; MF: RNA binding, metal ion binding, nucleic acid binding, protein binding, protein kinase binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: centrosome, chromosome, cytoplasm, cytoskeleton, cytosol, nuclear speck, nucleolus, nucleus, protein-containing complex
Pathways:
UniProt: Q7Z6E9
Entrez ID: 5930
|
Does Knockout of PRB1 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
PRB1
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: PRB1 (proline rich protein BstNI subfamily 1)
Type: protein-coding
Summary: This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Medium" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]
Gene Ontology:
Pathways: Salivary secretion - Homo sapiens (human), Spinal Cord Injury
UniProt: P04280
Entrez ID: 5542
|
Does Knockout of PSMB7 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
PSMB7
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: PSMB7 (proteasome 20S subunit beta 7)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: endopeptidase activity, hydrolase activity, peptidase activity, protein binding, threonine-type endopeptidase activity; CC: cilium, cytoplasm, cytosol, extracellular region, ficolin-1-rich granule lumen, nuclear body, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: Q99436
Entrez ID: 5695
|
Does Knockout of CCDC144A in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
CCDC144A
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CCDC144A (coiled-coil domain containing 144A)
Type: protein-coding
Summary: Predicted to enable calcium oxalate binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A2RUR9
Entrez ID: 9720
|
Does Knockout of RPL13 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
RPL13
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: RPL13 (ribosomal protein L13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: blastocyst development, bone development, cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, membrane, nucleolus, nucleus, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P26373
Entrez ID: 6137
|
Does Activation of AS3MT in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
AS3MT
|
response to virus
|
Hepatoma Cell Line
|
Gene: AS3MT (arsenite methyltransferase)
Type: protein-coding
Summary: AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: arsonoacetate metabolic process, methylation, toxin metabolic process; MF: arsenite methyltransferase activity, methyltransferase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Biological oxidations, Metabolism, Methylation, Phase II - Conjugation of compounds, arsenate detoxification I (glutaredoxin)
UniProt: Q9HBK9
Entrez ID: 57412
|
Does Knockout of CSGALNACT1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
CSGALNACT1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1)
Type: protein-coding
Summary: This gene encodes an enzyme that transfers N-acetylglucosamine (GalNAc) to the core tetrasaccharide linker and to elongating chondroitin sulfate chains in proteoglycans. Knockout of the orthologous mouse gene indicates that the protein is necessary for normal cartilage development and aggrecan metabolism. Mutations in this gene are associated with multiple sclerosis progression, and with mild skeletal dysplasia and joint laxity. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: UDP-N-acetylgalactosamine metabolic process, UDP-glucuronate metabolic process, cartilage development, chondroitin sulfate proteoglycan biosynthetic process, chondroitin sulfate proteoglycan metabolic process, dermatan sulfate proteoglycan biosynthetic process, endochondral ossification, extracellular matrix organization, heparan sulfate proteoglycan biosynthetic process, heparin proteoglycan biosynthetic process, proteoglycan biosynthetic process; MF: acetylgalactosaminyltransferase activity, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity, glucuronosyltransferase activity, glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity, metal ion binding, peptidoglycan glycosyltransferase activity, protein binding, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, membrane
Pathways: CS-GAG biosynthesis, Chondroitin sulfate/dermatan sulfate metabolism, Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human), Glycosaminoglycan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Proteoglycan biosynthesis, chondroitin and dermatan biosynthesis, chondroitin sulfate biosynthesis, chondroitin sulfate biosynthesis (late stages), dermatan sulfate biosynthesis
UniProt: Q8TDX6
Entrez ID: 55790
|
Does Knockout of AAR2 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
AAR2
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: AAR2 (AAR2 splicing factor)
Type: protein-coding
Summary: This gene encodes the homolog of the yeast A1-alpha2 repressin protein that is involved in mRNA splicing. Alternately spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: RNA splicing, mRNA processing, spliceosomal tri-snRNP complex assembly; CC: U5 snRNP, spliceosomal complex
Pathways: Ciliary landscape
UniProt: Q9Y312
Entrez ID: 25980
|
Does Knockout of POMGNT1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
POMGNT1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: POMGNT1 (protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-))
Type: protein-coding
Summary: This gene encodes a type II transmembrane protein that resides in the Golgi apparatus. It participates in O-mannosyl glycosylation and is specific for alpha linked terminal mannose. Mutations in this gene may be associated with muscle-eye-brain disease and several congenital muscular dystrophies. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: basement membrane organization, brain development, dentate gyrus development, gene expression, localization of cell, myelination, protein O-linked glycosylation, protein O-linked glycosylation via N-acetyl-galactosamine, protein O-linked glycosylation via mannose, protein glycosylation, protein modification process, reactive gliosis, sensory perception of sound; MF: acetylglucosaminyltransferase activity, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity, carbohydrate binding, glycosyltransferase activity, manganese ion binding, metal ion binding, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Ciliopathies, DAG1 core M1 glycosylations, DAG1 core M2 glycosylations, DAG1 glycosylations, Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Mannose type O-glycan biosynthesis - Homo sapiens (human), Matriglycan biosynthesis on DAG1, Metabolism of proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8WZA1
Entrez ID: 55624
|
Does Knockout of LCE1A in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
LCE1A
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: LCE1A (late cornified envelope 1A)
Type: protein-coding
Summary: LCE1A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these genes are expressed relatively late during fetal assembly of the skin cornified envelope (Jackson et al., 2005 [PubMed 15854049]). For further information on the LCE gene cluster, see GENE FAMILY below.[supplied by OMIM, Feb 2009].
Gene Ontology: BP: epidermis development, keratinization
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q5T7P2
Entrez ID: 353131
|
Does Knockout of AGR2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
AGR2
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: AGR2 (anterior gradient 2, protein disulphide isomerase family member)
Type: protein-coding
Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: digestive tract morphogenesis, inflammatory response, lung goblet cell differentiation, mucus secretion, positive regulation of IRE1-mediated unfolded protein response, positive regulation of PERK-mediated unfolded protein response, positive regulation of cell-substrate adhesion, positive regulation of developmental growth, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of gene expression, positive regulation of protein localization to plasma membrane, response to endoplasmic reticulum stress; MF: dystroglycan binding, epidermal growth factor receptor binding, identical protein binding, protein binding; CC: endoplasmic reticulum, extracellular region, extracellular space
Pathways:
UniProt: O95994
Entrez ID: 10551
|
Does Knockout of RPAP1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
RPAP1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: RPAP1 (RNA polymerase II associated protein 1)
Type: protein-coding
Summary: This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012].
Gene Ontology: MF: DNA binding, nucleotidyltransferase activity, protein binding, transferase activity; CC: DNA-directed RNA polymerase complex, nucleus
Pathways:
UniProt: Q9BWH6
Entrez ID: 26015
|
Does Knockout of NME5 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
NME5
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NME5 (NME/NM23 family member 5)
Type: protein-coding
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and spermatid development. Predicted to act upstream of or within cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and ventricular system development. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CTP biosynthetic process, DNA catabolic process, GTP biosynthetic process, UTP biosynthetic process, cell differentiation, cilium assembly, cilium movement, epithelial cilium movement involved in extracellular fluid movement, establishment of localization in cell, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, nucleoside metabolic process, spermatid development, spermatid differentiation, spermatogenesis, ventricular system development; MF: 3'-5'-DNA exonuclease activity, hydrolase activity, nucleoside diphosphate kinase activity, protein binding; CC: 9+2 motile cilium, cell projection, cilium, cytoplasm, cytoskeleton, extracellular region, motile cilium, radial spoke, sperm flagellum
Pathways: CMP phosphorylation, UTP and CTP <i>de novo</i> biosynthesis, adenosine deoxyribonucleotides <i>de novo</i> biosynthesis, guanosine deoxyribonucleotides <i>de novo</i> biosynthesis, guanosine nucleotides <i>de novo</i> biosynthesis, guanosine ribonucleotides <i>de novo</i> biosynthesis, purine deoxyribonucleosides salvage, purine nucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotide phosphorylation, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides biosynthesis from CTP, superpathway of purine nucleotide salvage, superpathway of pyrimidine deoxyribonucleoside salvage, superpathway of pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, superpathway of pyrimidine ribonucleotides <i>de novo</i> biosynthesis
UniProt: P56597
Entrez ID: 8382
|
Does Activation of DACH2 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
DACH2
|
protein/peptide accumulation
|
T cell
|
Gene: DACH2 (dachshund family transcription factor 2)
Type: protein-coding
Summary: This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008].
Gene Ontology: BP: development of primary female sexual characteristics, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding; CC: nucleus, transcription regulator complex
Pathways:
UniProt: Q96NX9
Entrez ID: 117154
|
Does Knockout of ACIN1 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
ACIN1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: ACIN1 (apoptotic chromatin condensation inducer 1)
Type: protein-coding
Summary: Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: RNA splicing, apoptotic chromosome condensation, apoptotic process, erythrocyte differentiation, mRNA processing, negative regulation of mRNA splicing, via spliceosome, positive regulation of apoptotic process, positive regulation of monocyte differentiation; MF: ATP hydrolysis activity, RNA binding, enzyme binding, nucleic acid binding, protein binding; CC: ASAP complex, cytosol, exon-exon junction complex, nuclear lumen, nuclear speck, nucleoplasm, nucleus, plasma membrane
Pathways: RNA transport - Homo sapiens (human), Spliceosome - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9UKV3
Entrez ID: 22985
|
Does Knockout of ZBTB37 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
ZBTB37
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ZBTB37 (zinc finger and BTB domain containing 37)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromatin, nucleoplasm, nucleus
Pathways:
UniProt: Q5TC79
Entrez ID: 84614
|
Does Knockout of IFIT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
IFIT1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: IFIT1 (interferon induced protein with tetratricopeptide repeats 1)
Type: protein-coding
Summary: This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: antiviral innate immune response, cellular response to exogenous dsRNA, cellular response to type I interferon, defense response to virus, immune system process, innate immune response, intracellular transport of viral protein in host cell, negative regulation of viral genome replication, negative regulation of viral translation, positive regulation of viral genome replication, response to other organism, response to virus; MF: RNA binding, RNA sequestering activity, enzyme inhibitor activity, protein binding; CC: cytoplasm, cytosol, host cell
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Hepatitis C - Homo sapiens (human), ISG15 antiviral mechanism, Immune System, Immune response to tuberculosis, Interferon Signaling, Interferon alpha/beta signaling
UniProt: P09914
Entrez ID: 3434
|
Does Knockout of LIN54 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
LIN54
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: LIN54 (lin-54 DREAM MuvB core complex component)
Type: protein-coding
Summary: LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010].
Gene Ontology: BP: nucleosome organization, regulation of DNA-templated transcription; MF: DNA binding, metal ion binding, minor groove of adenine-thymine-rich DNA binding, protein binding, transcription regulatory region nucleic acid binding; CC: RNA polymerase II transcription repressor complex, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cellular senescence - Homo sapiens (human), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , G0 and Early G1, G1/S Transition, G1/S-Specific Transcription, G2/M Transition, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Polo-like kinase mediated events, S Phase, Transcription of E2F targets under negative control by DREAM complex, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
UniProt: Q6MZP7
Entrez ID: 132660
|
Does Knockout of ZFYVE27 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
ZFYVE27
|
response to virus
|
Huh-7 Cell
|
Gene: ZFYVE27 (zinc finger FYVE-type containing 27)
Type: protein-coding
Summary: This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: endoplasmic reticulum tubular network formation, neuron projection development, neurotrophin TRK receptor signaling pathway, positive regulation of axon extension, protein localization to plasma membrane, vesicle-mediated transport; MF: identical protein binding, metal ion binding, protein binding, zinc ion binding; CC: axon, cell projection, cytoplasm, cytosol, dendrite, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, endosome, growth cone membrane, membrane, nucleoplasm, plasma membrane, recycling endosome membrane
Pathways: Endocytosis - Homo sapiens (human)
UniProt: Q5T4F4
Entrez ID: 118813
|
Does Knockout of MIS18BP1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
MIS18BP1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MIS18BP1 (MIS18 binding protein 1)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be involved in cell division. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CENP-A containing chromatin assembly, cell division, pericentric heterochromatin organization; MF: DNA binding, protein binding; CC: CENP-A recruiting complex, chromosome, chromosome, centromeric region, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, Cyclin A/B1/B2 associated events during G2/M transition, Deposition of new CENPA-containing nucleosomes at the centromere, G2/M Transition, Mitotic G2-G2/M phases, Nucleosome assembly
UniProt: Q6P0N0
Entrez ID: 55320
|
Does Knockout of XRN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
XRN1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: XRN1 (5'-3' exoribonuclease 1)
Type: protein-coding
Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: RNA metabolic process, cellular response to cycloheximide, cellular response to puromycin, histone mRNA catabolic process, negative regulation of telomere maintenance via telomerase, negative regulation of translation, nuclear mRNA surveillance, nuclear-transcribed mRNA catabolic process, rRNA catabolic process, response to testosterone; MF: 5'-3' RNA exonuclease activity, 5'-3' exonuclease activity, DNA binding, G-quadruplex DNA binding, G-quadruplex RNA binding, RNA binding, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, protein binding, telomerase RNA binding; CC: P-body, cytoplasm, cytosol, dendrite, membrane, neuronal cell body, nucleus, plasma membrane
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q8IZH2
Entrez ID: 54464
|
Does Knockout of NOL6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
NOL6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: NOL6 (nucleolar protein 6)
Type: protein-coding
Summary: The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, tRNA export from nucleus; MF: RNA binding, protein binding; CC: CURI complex, UTP-C complex, chromosome, condensed nuclear chromosome, mitochondrion, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q9H6R4
Entrez ID: 65083
|
Does Knockout of DDX47 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
DDX47
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: DDX47 (DEAD-box helicase 47)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, apoptotic process, extrinsic apoptotic signaling pathway via death domain receptors, mRNA processing, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: membrane, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9H0S4
Entrez ID: 51202
|
Does Knockout of DRC3 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
DRC3
|
cell proliferation
|
Cancer Cell Line
|
Gene: DRC3 (dynein regulatory complex subunit 3)
Type: protein-coding
Summary: Located in axoneme. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: axoneme, cell projection, cilium, cytoplasm, cytoskeleton, motile cilium, sperm flagellum
Pathways:
UniProt: Q9H069
Entrez ID: 83450
|
Does Knockout of ADRA1D in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
ADRA1D
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: ADRA1D (adrenoceptor alpha 1D)
Type: protein-coding
Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell-cell signaling, neuron-glial cell signaling, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of cell population proliferation, positive regulation of cytosolic calcium ion concentration, positive regulation of vasoconstriction, signal transduction; MF: G protein-coupled receptor activity, adrenergic receptor activity, alpha1-adrenergic receptor activity, identical protein binding, protein binding; CC: membrane, plasma membrane
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Adrenoceptors, Amine ligand-binding receptors, Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), G alpha (12/13) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, GPCRs, Other, Monoamine GPCRs, Neuroactive ligand-receptor interaction - Homo sapiens (human), Salivary secretion - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Vascular smooth muscle contraction - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P25100
Entrez ID: 146
|
Does Knockout of MPPE1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
MPPE1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: MPPE1 (metallophosphoesterase 1)
Type: protein-coding
Summary: Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Involved in GPI anchor biosynthetic process. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: GPI anchor biosynthetic process, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle-mediated transport; MF: GPI-mannose ethanolamine phosphate phosphodiesterase activity, hydrolase activity, manganese ion binding, metal ion binding, phosphoric diester hydrolase activity, protein binding; CC: Golgi apparatus, endoplasmic reticulum exit site, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, nucleoplasm
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Homo sapiens (human)
UniProt: Q53F39
Entrez ID: 65258
|
Does Knockout of SNX14 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
SNX14
|
response to chemicals
|
Melanoma Cell Line
|
Gene: SNX14 (sorting nexin 14)
Type: protein-coding
Summary: This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: autophagosome maturation, postsynaptic modulation of chemical synaptic transmission, protein transport; MF: phosphatidylinositol binding, phosphatidylinositol-3,5-bisphosphate binding; CC: cell projection, cytosol, dendrite, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, postsynapse, synapse
Pathways:
UniProt: Q9Y5W7
Entrez ID: 57231
|
Does Knockout of DDX54 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
DDX54
|
cell proliferation
|
T-lymphoma cell line
|
Gene: DDX54 (DEAD-box helicase 54)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA metabolic process, RNA processing, estrogen receptor signaling pathway, negative regulation of DNA-templated transcription, rRNA processing; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nuclear estrogen receptor binding, nucleic acid binding, nucleotide binding, signaling receptor binding, transcription corepressor activity; CC: Golgi apparatus, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Validated nuclear estrogen receptor alpha network, Validated nuclear estrogen receptor beta network
UniProt: Q8TDD1
Entrez ID: 79039
|
Does Knockout of TM7SF2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
TM7SF2
|
cell proliferation
|
Cancer Cell Line
|
Gene: TM7SF2 (transmembrane 7 superfamily member 2)
Type: protein-coding
Summary: Enables delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in endoplasmic reticulum. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol metabolic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: Delta14-sterol reductase activity, NADP binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear inner membrane, organelle membrane, plasma membrane, receptor complex
Pathways: Activation of gene expression by SREBF (SREBP), Alendronate Action Pathway, Atorvastatin Action Pathway, CHILD Syndrome, Cerivastatin Action Pathway, Cholesterol biosynthesis, Cholesterol biosynthesis via lathosterol, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Cholesteryl ester storage disease, Chondrodysplasia Punctata II, X Linked Dominant (CDPX2), Desmosterolosis, Fluvastatin Action Pathway, Hyper-IgD syndrome, Hypercholesterolemia, Ibandronate Action Pathway, Lovastatin Action Pathway, Lysosomal Acid Lipase Deficiency (Wolman Disease), Metabolism, Metabolism of lipids, Metabolism of steroids, Mevalonic aciduria, Pamidronate Action Pathway, Pravastatin Action Pathway, Regulation of cholesterol biosynthesis by SREBP (SREBF), Risedronate Action Pathway, Rosuvastatin Action Pathway, Simvastatin Action Pathway, Smith-Lemli-Opitz Syndrome (SLOS), Steroid Biosynthesis, Steroid biosynthesis - Homo sapiens (human), Wolman disease, Zoledronate Action Pathway, cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), superpathway of cholesterol biosynthesis, zymosterol biosynthesis
UniProt: O76062
Entrez ID: 7108
|
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