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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of EDARADD in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
EDARADD
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: EDARADD (EDAR associated via death domain)
Type: protein-coding
Summary: This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, signal transduction; CC: cytoplasm, cytosol
Pathways: Cytokine Signaling in Immune system, EDA signaling in hair follicle development, Immune System, NF-kappa B signaling pathway - Homo sapiens (human), TNFR2 non-canonical NF-kB pathway, TNFs bind their physiological receptors
UniProt: Q8WWZ3
Entrez ID: 128178
|
Does Knockout of SLC3A1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
SLC3A1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SLC3A1 (solute carrier family 3 member 1)
Type: protein-coding
Summary: This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: L-cystine transport, L-glutamate transmembrane transport, amino acid transport, aspartate transmembrane transport, basic amino acid transmembrane transport, basic amino acid transport, carbohydrate metabolic process, gene expression; MF: L-cystine transmembrane transporter activity, amino acid transmembrane transporter activity, basic amino acid transmembrane transporter activity, protein binding, protein heterodimerization activity, protein-containing complex binding; CC: apical plasma membrane, brush border membrane, extracellular exosome, membrane, plasma membrane, vacuolar membrane
Pathways: Amiloride Action Pathway, Amino acid transport across the plasma membrane, Bendroflumethiazide Action Pathway, Blue diaper syndrome, Bumetanide Action Pathway, Chlorothiazide Action Pathway, Chlorthalidone Action Pathway, Cyclothiazide Action Pathway, Cystinuria, Defective SLC3A1 causes cystinuria (CSNU), Defective SLC7A9 causes cystinuria (CSNU), Disease, Disorders of transmembrane transporters, Eplerenone Action Pathway, Ethacrynic Acid Action Pathway, Furosemide Action Pathway, Glucose Transporter Defect (SGLT2), Hartnup Disorder, Hydrochlorothiazide Action Pathway, Hydroflumethiazide Action Pathway, Iminoglycinuria, Indapamide Action Pathway, Kidney Function, Lysinuric Protein Intolerance, Lysinuric protein intolerance (LPI), Methyclothiazide Action Pathway, Metolazone Action Pathway, Polythiazide Action Pathway, Protein digestion and absorption - Homo sapiens (human), Proximal tubule transport, Quinethazone Action Pathway, SLC transporter disorders, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Spironolactone Action Pathway, Torsemide Action Pathway, Transport of small molecules, Triamterene Action Pathway, Trichlormethiazide Action Pathway
UniProt: Q07837
Entrez ID: 6519
|
Does Knockout of TPR in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
TPR
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TPR (translocated promoter region, nuclear basket protein)
Type: protein-coding
Summary: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA export from nucleus, RNA import into nucleus, cell division, cellular response to heat, cellular response to interferon-alpha, intracellular protein transport, mRNA export from nucleus, mRNA export from nucleus in response to heat stress, mRNA transport, mitotic spindle assembly checkpoint signaling, negative regulation of RNA export from nucleus, negative regulation of transcription by RNA polymerase II, negative regulation of translational initiation, nuclear export, nuclear matrix organization, nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport, positive regulation of heterochromatin formation, positive regulation of intracellular protein transport, positive regulation of mitotic cell cycle spindle assembly checkpoint, positive regulation of nucleocytoplasmic transport, positive regulation of protein export from nucleus, positive regulation of protein import into nucleus, protein export from nucleus, protein import into nucleus, protein transport, regulation of mRNA export from nucleus, regulation of mitotic sister chromatid separation, regulation of mitotic spindle assembly, regulation of protein export from nucleus, regulation of protein import into nucleus, regulation of protein localization, regulation of protein stability, response to epidermal growth factor; MF: RNA binding, chromatin binding, dynein complex binding, heat shock protein binding, mRNA binding, mitogen-activated protein kinase binding, protein binding, protein homodimerization activity, protein-membrane adaptor activity, structural constituent of nuclear pore, tubulin binding; CC: chromosome, chromosome, centromeric region, cytoplasm, cytoplasmic dynein complex, cytoskeleton, kinetochore, membrane, mitotic spindle, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore nuclear basket, nucleoplasm, nucleus, spindle
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Pathways in cancer - Homo sapiens (human), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Thyroid cancer - Homo sapiens (human), Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: P12270
Entrez ID: 7175
|
Does Knockout of LMF1 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
LMF1
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: LMF1 (lipase maturation factor 1)
Type: protein-coding
Summary: Involved in triglyceride metabolic process. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Implicated in familial lipase maturation factor 1 deficiency. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chylomicron remnant clearance, endoplasmic reticulum to Golgi vesicle-mediated transport, protein glycosylation, protein maturation, protein secretion, regulation of cholesterol metabolic process, regulation of triglyceride metabolic process, triglyceride metabolic process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Assembly of active LPL and LIPC lipase complexes, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Transport of small molecules
UniProt: Q96S06
Entrez ID: 64788
|
Does Knockout of EMC6 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
EMC6
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: EMC6 (ER membrane protein complex subunit 6)
Type: protein-coding
Summary: Contributes to membrane insertase activity. Involved in autophagosome assembly; protein insertion into ER membrane by stop-transfer membrane-anchor sequence; and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane and integral component of omegasome membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagosome assembly, protein insertion into ER membrane by stop-transfer membrane-anchor sequence, tail-anchored membrane protein insertion into ER membrane; MF: membrane insertase activity, protein binding; CC: EMC complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, omegasome membrane
Pathways:
UniProt: Q9BV81
Entrez ID: 83460
|
Does Knockout of RPP14 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
RPP14
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: RPP14 (ribonuclease P/MRP subunit p14)
Type: protein-coding
Summary: This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017].
Gene Ontology: BP: tRNA 5'-leader removal, tRNA processing; MF: RNA binding, protein binding, ribonuclease P RNA binding, ribonuclease P activity; CC: endoribonuclease complex, multimeric ribonuclease P complex, nucleolus, nucleoplasm, nucleus, ribonuclease P complex, ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, RNA transport - Homo sapiens (human), rRNA processing, rRNA processing in the nucleus and cytosol, tRNA processing, tRNA processing in the nucleus
UniProt: O95059
Entrez ID: 11102
|
Does Knockout of ZMAT4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
ZMAT4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ZMAT4 (zinc finger matrin-type 4)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, identical protein binding, metal ion binding, nucleic acid binding, protein binding, zinc ion binding
Pathways:
UniProt: Q9H898
Entrez ID: 79698
|
Does Knockout of SEC14L5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
SEC14L5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SEC14L5 (SEC14 like lipid binding 5)
Type: protein-coding
Summary: Predicted to be located in mitochondrial intermembrane space. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: O43304
Entrez ID: 9717
|
Does Knockout of MAP4K2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
MAP4K2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: JNK cascade, immune response, immune system process, innate immune response, intracellular signal transduction, positive regulation of JNK cascade, positive regulation of JUN kinase activity, protein phosphorylation, vesicle targeting; MF: ATP binding, MAP kinase kinase kinase kinase activity, kinase activity, mitogen-activated protein kinase kinase kinase binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, basolateral plasma membrane, cytoplasm, membrane, plasma membrane
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, Hippo-Yap signaling pathway, Insulin Signaling, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, TNF receptor signaling pathway , TNF-alpha signaling pathway, TNFalpha, role of mal in rho-mediated activation of srf, tnf/stress related signaling
UniProt: Q12851
Entrez ID: 5871
|
Does Knockout of KATNB1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
KATNB1
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: KATNB1 (katanin regulatory subunit B1)
Type: protein-coding
Summary: Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell division, cytoplasmic microtubule organization, microtubule depolymerization, microtubule severing, mitotic chromosome movement towards spindle pole, negative regulation of microtubule depolymerization, positive regulation of apoptotic process, positive regulation of microtubule depolymerization, positive regulation of neuron projection development, protein targeting; MF: ATPase regulator activity, dynein complex binding, microtubule binding, protein binding, protein heterodimerization activity; CC: axon, centrosome, cytoplasm, cytoskeleton, cytosol, growth cone, katanin complex, membrane, microtubule, microtubule cytoskeleton, microtubule organizing center, midbody, neuronal cell body, nucleus, plasma membrane, spindle, spindle pole
Pathways: Genes related to primary cilium development (based on CRISPR)
UniProt: Q9BVA0
Entrez ID: 10300
|
Does Knockout of EIF2B3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
EIF2B3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)
Type: protein-coding
Summary: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: T cell receptor signaling pathway, central nervous system development, cytoplasmic translational initiation, oligodendrocyte development, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, protein binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Translation, Translation Factors
UniProt: Q9NR50
Entrez ID: 8891
|
Does Knockout of LONP2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
LONP2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: LONP2 (lon peptidase 2, peroxisomal)
Type: protein-coding
Summary: In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: peroxisome organization, protein catabolic process, protein import into peroxisome matrix, protein processing, protein quality control for misfolded or incompletely synthesized proteins, protein targeting to peroxisome, proteolysis, regulation of fatty acid beta-oxidation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, enzyme binding, hydrolase activity, nucleotide binding, peptidase activity, protease binding, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, cytosol, membrane, nucleus, peroxisomal matrix, peroxisome
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, IL-18 signaling pathway, Metabolism of proteins, Peroxisomal protein import, Protein folding, Protein localization
UniProt: Q86WA8
Entrez ID: 83752
|
Does Knockout of RPL18 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
RPL18
|
cell proliferation
|
Melanoma Cell Line
|
Gene: RPL18 (ribosomal protein L18)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, focal adhesion, membrane, nucleolus, nucleus, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q07020
Entrez ID: 6141
|
Does Knockout of NOM1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
NOM1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: NOM1 (nucleolar protein with MIF4G domain 1)
Type: protein-coding
Summary: Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: hair follicle maturation, ribosomal small subunit biogenesis; MF: RNA binding, protein binding; CC: nucleolus, nucleus
Pathways:
UniProt: Q5C9Z4
Entrez ID: 64434
|
Does Knockout of FABP12 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
FABP12
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: FABP12 (fatty acid binding protein 12)
Type: protein-coding
Summary: Predicted to enable lipid binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: fatty acid binding, lipid binding; CC: cytosol, nucleus
Pathways: Metabolism, Metabolism of lipids, Triglyceride catabolism, Triglyceride metabolism
UniProt: A6NFH5
Entrez ID: 646486
|
Does Knockout of POU1F1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
POU1F1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: POU1F1 (POU class 1 homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adenohypophysis development, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, lncRNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytosol, nucleoplasm, nucleus
Pathways: Glucocorticoid receptor regulatory network, Growth hormone synthesis, secretion and action - Homo sapiens (human)
UniProt: P28069
Entrez ID: 5449
|
Does Knockout of DAAM1 in Lung Cancer Cell Line causally result in response to radiation?
| 1
| 1,952
|
Knockout
|
DAAM1
|
response to radiation
|
Lung Cancer Cell Line
|
Gene: DAAM1 (dishevelled associated activator of morphogenesis 1)
Type: protein-coding
Summary: Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: Wnt signaling pathway, Wnt signaling pathway, planar cell polarity pathway, actin cytoskeleton organization, presynaptic actin cytoskeleton organization; MF: actin binding, identical protein binding, protein binding, small GTPase binding; CC: cell projection, ciliary basal body, cytoplasm, cytoskeleton, cytosol, glutamatergic synapse, membrane, motile cilium, perinuclear region of cytoplasm, plasma membrane, presynapse, stress fiber, synapse
Pathways: Association Between Physico-Chemical Features and Toxicity Associated Pathways, Genotoxicity pathway, Noncanonical Wnt signaling pathway, Wnt, Wnt signaling, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q9Y4D1
Entrez ID: 23002
|
Does Knockout of PYROXD1 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
PYROXD1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1)
Type: protein-coding
Summary: This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other proteins. The encoded protein belongs to the class I pyridine nucleotide-disulphide oxidoreductase family but lacks the C-terminal dimerization domain found in other family members and instead has a C-terminal nitrile reductase domain. It localizes to the nucleus and to striated sarcomeric compartments. Naturally occurring mutations in this gene cause early-onset myopathy with internalized nuclei and myofibrillar disorganization. A pseudogene of this gene has been defined on chromosome 11. [provided by RefSeq, Apr 2017].
Gene Ontology: MF: NAD(P)H oxidase H2O2-forming activity, oxidoreductase activity, protein binding; CC: cytoplasm, nucleus, sarcomere
Pathways:
UniProt: Q8WU10
Entrez ID: 79912
|
Does Knockout of DOCK1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
DOCK1
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: DOCK1 (dedicator of cytokinesis 1)
Type: protein-coding
Summary: This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: apoptotic process, cell migration, integrin-mediated signaling pathway, myoblast fusion, phagocytosis, phagocytosis, engulfment, positive regulation of epithelial cell migration, positive regulation of substrate adhesion-dependent cell spreading, regulation of postsynapse assembly, signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity, SH3 domain binding, guanyl-nucleotide exchange factor activity, protein binding, small GTPase binding; CC: cytoplasm, cytosol, glutamatergic synapse, guanyl-nucleotide exchange factor complex, membrane, plasma membrane, postsynapse
Pathways: Alpha4 beta1 integrin signaling events, Axon guidance, Bacterial invasion of epithelial cells - Homo sapiens (human), DCC mediated attractive signaling, Developmental Biology, Disease, EGFR1, FCGR3A-mediated phagocytosis, Factors involved in megakaryocyte development and platelet production, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, Focal Adhesion, Focal adhesion - Homo sapiens (human), Hemostasis, Immune System, Infectious disease, Innate Immune System, Integrin-mediated Cell Adhesion, Leishmania infection, Leishmania phagocytosis, Nervous system development, Netrin-1 signaling, Netrin-mediated signaling events, Neurotrophic factor-mediated Trk receptor signaling, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, Parasite infection, Parasitic Infection Pathways, RAC1 GTPase cycle, RAC2 GTPase cycle, RHO GTPase cycle, RHOG GTPase cycle, Regulation of Actin Cytoskeleton, Regulation of RAC1 activity, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Signaling events mediated by focal adhesion kinase, Signaling of Hepatocyte Growth Factor Receptor, Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling, VEGFA-VEGFR2 Pathway, Yersinia infection - Homo sapiens (human)
UniProt: Q14185
Entrez ID: 1793
|
Does Knockout of BNIP3L in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
BNIP3L
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: BNIP3L (BCL2 interacting protein 3 like)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: apoptotic process, cellular response to hypoxia, defense response to virus, mitochondrial outer membrane permeabilization, mitochondrial protein catabolic process, negative regulation of apoptotic process, negative regulation of mitochondrial membrane potential, negative regulation of programmed cell death, positive regulation of apoptotic process, positive regulation of macroautophagy, positive regulation of mitochondrial membrane permeability, regulation of mitophagy, regulation of programmed cell death, regulation of protein targeting to mitochondrion; MF: identical protein binding, lamin binding, protein binding, protein homodimerization activity; CC: endoplasmic reticulum, membrane, mitochondrial envelope, mitochondrial outer membrane, mitochondrion, nuclear envelope, nuclear speck, nucleus
Pathways: Apoptosis, Direct p53 effectors, Gene expression (Transcription), Generic Transcription Pathway, Mitophagy - animal - Homo sapiens (human), Photodynamic therapy-induced HIF-1 survival signaling, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53
UniProt: O60238
Entrez ID: 665
|
Does Knockout of TIMM10 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
TIMM10
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: TIMM10 (translocase of inner mitochondrial membrane 10)
Type: protein-coding
Summary: The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: protein insertion into mitochondrial inner membrane, protein targeting to mitochondrion, protein transport, sensory perception of sound; MF: membrane insertase activity, metal ion binding, protein binding, protein homodimerization activity, protein-folding chaperone binding, zinc ion binding; CC: TIM22 mitochondrial import inner membrane insertion complex, TIM23 mitochondrial import inner membrane translocase complex, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial intermembrane space chaperone complex, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial protein import, Protein localization
UniProt: P62072
Entrez ID: 26519
|
Does Knockout of VIRMA in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
VIRMA
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: VIRMA (vir like m6A methyltransferase associated)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA alternative polyadenylation and mRNA methylation. Located in cytosol and nuclear speck. Colocalizes with RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing; MF: RNA binding, protein binding; CC: RNA N6-methyladenosine methyltransferase complex, cytoplasm, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q69YN4
Entrez ID: 25962
|
Does Knockout of SP8 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
SP8
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SP8 (Sp8 transcription factor)
Type: protein-coding
Summary: The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: dorsal/ventral pattern formation, embryonic limb morphogenesis, proximal/distal pattern formation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromatin, nucleus
Pathways:
UniProt: Q8IXZ3
Entrez ID: 221833
|
Does Knockout of DCLK1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
DCLK1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: DCLK1 (doublecortin like kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010].
Gene Ontology: BP: axon extension, cell differentiation, central nervous system development, endosomal transport, intracellular signal transduction, nervous system development, protein localization to nucleus, protein phosphorylation, response to virus; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, plasma membrane
Pathways:
UniProt: O15075
Entrez ID: 9201
|
Does Knockout of ARHGDIA in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
ARHGDIA
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ARHGDIA (Rho GDP dissociation inhibitor alpha)
Type: protein-coding
Summary: This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: Rho protein signal transduction, negative regulation of apoptotic process, regulation of Rho protein signal transduction, regulation of protein localization, regulation of synaptic vesicle cycle, semaphorin-plexin signaling pathway; MF: GTPase activator activity, Rho GDP-dissociation inhibitor activity, protein binding; CC: Schaffer collateral - CA1 synapse, cytoplasm, cytoskeleton, cytosol, extracellular exosome, immunological synapse, membrane, nucleus
Pathways: Axonal growth inhibition (RHOA activation), Axonal growth stimulation, CDC42 GTPase cycle, CDC42 signaling events, Ciliary landscape, Death Receptor Signaling, Nephrotic syndrome, Neurotrophin signaling pathway - Homo sapiens (human), PAR1-mediated thrombin signaling events, PDGFR-beta signaling pathway, RAC1 GTPase cycle, RAC1 signaling pathway, RAC2 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOC GTPase cycle, RHOG GTPase cycle, RHOH GTPase cycle, Regulation of CDC42 activity, Regulation of RAC1 activity, Regulation of RhoA activity, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vasopressin-regulated water reabsorption - Homo sapiens (human), p75 NTR receptor-mediated signalling, p75(NTR)-mediated signaling, p75NTR regulates axonogenesis
UniProt: P52565
Entrez ID: 396
|
Does Knockout of GABPB1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
GABPB1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GABPB1 (GA binding protein transcription factor subunit beta 1)
Type: protein-coding
Summary: This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrion organization, positive regulation of transcription by RNA polymerase II; MF: protein binding, transcription cis-regulatory region binding; CC: cytoplasmic ribonucleoprotein granule, nucleoplasm, nucleus
Pathways: Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex, Mitochondrial Gene Expression, Mitochondrial biogenesis, Myometrial relaxation and contraction pathways, Organelle biogenesis and maintenance, Transcriptional activation of mitochondrial biogenesis
UniProt: Q06547
Entrez ID: 2553
|
Does Knockout of CYP2A6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
CYP2A6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CYP2A6 (cytochrome P450 family 2 subfamily A member 6)
Type: protein-coding
Summary: This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: coumarin catabolic process, coumarin metabolic process, epoxygenase P450 pathway, lipid metabolic process, steroid metabolic process, xenobiotic catabolic process, xenobiotic metabolic process; MF: arachidonate epoxygenase activity, coumarin 7-hydroxylase activity, enzyme binding, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, protein binding; CC: cytoplasm, cytoplasmic microtubule, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Acetaminophen Metabolism Pathway, Biological oxidations, CYP2E1 reactions, Caffeine Metabolism, Caffeine and Theobromine metabolism, Caffeine metabolism - Homo sapiens (human), Chemical carcinogenesis - Homo sapiens (human), Constitutive Androstane Receptor Pathway, Cyclophosphamide Action Pathway, Cyclophosphamide Metabolism Pathway, Cytochrome P450 - arranged by substrate type, Drug metabolism - cytochrome P450 - Homo sapiens (human), Drug metabolism - other enzymes - Homo sapiens (human), Fatty Acid Omega Oxidation, Fluoropyrimidine Activity, Ifosfamide Action Pathway, Ifosfamide Metabolism Pathway, Lipid and atherosclerosis - Homo sapiens (human), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human), Metapathway biotransformation Phase I and II, NRF2 pathway, Nicotine Action Pathway, Nicotine Metabolism, Nicotine Metabolism Pathway, Nuclear Receptors Meta-Pathway, Oxidation by Cytochrome P450, Phase I - Functionalization of compounds, Pregnane X receptor pathway, Retinol Metabolism, Retinol metabolism - Homo sapiens (human), Tamoxifen metabolism, Valproic Acid Metabolism Pathway, Valproic acid pathway, Vitamin A Deficiency, Xenobiotics, acetone degradation I (to methylglyoxal), bupropion degradation, estradiol biosynthesis I, estradiol biosynthesis II, melatonin degradation I, nicotine degradation III, nicotine degradation IV, superpathway of melatonin degradation, superpathway of steroid hormone biosynthesis, superpathway of tryptophan utilization
UniProt: P11509
Entrez ID: 1548
|
Does Knockout of HECW1 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
HECW1
|
response to virus
|
Lung Cancer Cell Line
|
Gene: HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of canonical Wnt signaling pathway, protein ubiquitination, regulation of dendrite morphogenesis, ubiquitin-dependent protein catabolic process; MF: protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: cytoplasm, cytosol
Pathways: Degradation of DVL, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q76N89
Entrez ID: 23072
|
Does Knockout of CLMN in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
CLMN
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: CLMN (calmin)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in negative regulation of cell population proliferation and nuclear migration. Predicted to act upstream of or within neuron projection development. Predicted to be integral component of membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in cytoplasm and nuclear outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of cell population proliferation, neuron projection development, nuclear migration; MF: actin binding, actin filament binding; CC: cytoplasm, meiotic nuclear membrane microtubule tethering complex, membrane, nuclear outer membrane
Pathways: Vitamin D Receptor Pathway
UniProt: Q96JQ2
Entrez ID: 79789
|
Does Knockout of PPOX in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
PPOX
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: PPOX (protoporphyrinogen oxidase)
Type: protein-coding
Summary: This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: heme A biosynthetic process, heme B biosynthetic process, heme O biosynthetic process, heme biosynthetic process, porphyrin-containing compound biosynthetic process, protoporphyrinogen IX biosynthetic process, protoporphyrinogen IX metabolic process, response to xenobiotic stimulus; MF: flavin adenine dinucleotide binding, oxidoreductase activity, oxygen-dependent protoporphyrinogen oxidase activity; CC: membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion
Pathways: Acute Intermittent Porphyria, Congenital Erythropoietic Porphyria (CEP) or Gunther Disease, Heme Biosynthesis, Heme biosynthesis, Hereditary Coproporphyria (HCP), Metabolism, Metabolism of porphyrins, Porphyria Variegata (PV), Porphyrin Metabolism, Porphyrin and chlorophyll metabolism - Homo sapiens (human), heme biosynthesis, heme biosynthesis from uroporphyrinogen-III I
UniProt: P50336
Entrez ID: 5498
|
Does Knockout of EIF2B4 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
EIF2B4
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)
Type: protein-coding
Summary: Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell receptor signaling pathway, animal organ development, central nervous system development, cytoplasmic translational initiation, myelination, oligodendrocyte development, ovarian follicle development, regulation of translation, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, protein binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Translation, Translation Factors
UniProt: Q9UI10
Entrez ID: 8890
|
Does Knockout of SREBF2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
SREBF2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SREBF2 (sterol regulatory element binding transcription factor 2)
Type: protein-coding
Summary: This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: SREBP signaling pathway, cellular response to laminar fluid shear stress, cellular response to low-density lipoprotein particle stimulus, cellular response to starvation, cholesterol homeostasis, cholesterol metabolic process, lipid metabolic process, negative regulation of amyloid-beta clearance, negative regulation of cholesterol efflux, negative regulation of transcription by RNA polymerase II, positive regulation of cholesterol biosynthetic process, positive regulation of cholesterol storage, positive regulation of miRNA transcription, positive regulation of protein targeting to mitochondrion, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of Notch signaling pathway, regulation of mitophagy, regulation of transcription by RNA polymerase II, steroid metabolic process; MF: C-8 sterol isomerase activity, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, SREBP-SCAP-Insig complex, chromatin, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm, nucleus
Pathways: 22q11.2 copy number variation syndrome, Activation of gene expression by SREBF (SREBP), Adipogenesis, Angiopoietin Like Protein 8 Regulatory Pathway, Cholesterol biosynthesis, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Developmental Biology, EGR2 and SOX10-mediated initiation of Schwann cell myelination, Metabolism, Metabolism of lipids, Metabolism of steroids, Nervous system development, PPARA activates gene expression, Regulation of cholesterol biosynthesis by SREBP (SREBF), Regulation of lipid metabolism by PPARalpha, SREBF and miR33 in cholesterol and lipid homeostasis, Sterol regulatory element-binding proteins (SREBP) signaling, Transcriptional regulation of white adipocyte differentiation, srebp control of lipid synthesis
UniProt: Q12772
Entrez ID: 6721
|
Does Knockout of NCLN in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
NCLN
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: NCLN (nicalin)
Type: protein-coding
Summary: Enables ribosome binding activity. Involved in protein stabilization; regulation of protein complex stability; and regulation of protein-containing complex assembly. Located in endoplasmic reticulum membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: determination of left/right asymmetry in lateral mesoderm, multi-pass transmembrane protein insertion into ER membrane, negative regulation of nodal signaling pathway, protein stabilization, regulation of protein complex stability, regulation of protein-containing complex assembly, regulation of signal transduction; MF: protein binding, ribosome binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, multi-pass translocon complex, protein-containing complex
Pathways:
UniProt: Q969V3
Entrez ID: 56926
|
Does Knockout of PKMYT1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
PKMYT1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, meiotic cell cycle, mitotic cell cycle, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of G2/MI transition of meiotic cell cycle, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of mitotic nuclear division; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Cell cycle, Cell cycle - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human)
UniProt: Q99640
Entrez ID: 9088
|
Does Knockout of WDR12 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
WDR12
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: WDR12 (WD repeat domain 12)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008].
Gene Ontology: BP: Notch signaling pathway, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, regulation of cell cycle, ribosomal large subunit biogenesis, ribosome biogenesis; MF: protein binding, ribonucleoprotein complex binding; CC: PeBoW complex, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9GZL7
Entrez ID: 55759
|
Does Knockout of CDC45 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
CDC45
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: CDC45 (cell division cycle 45)
Type: protein-coding
Summary: The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: DNA replication, DNA replication checkpoint signaling, DNA replication initiation, double-strand break repair via break-induced replication, mitotic DNA replication preinitiation complex assembly; MF: DNA replication origin binding, chromatin binding, protein binding, single-stranded DNA binding; CC: CMG complex, DNA replication preinitiation complex, centrosome, chromosome, ciliary basal body, nucleoplasm, nucleus
Pathways: 22q11.2 copy number variation syndrome, Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), DNA Replication, DNA Replication Pre-Initiation, DNA strand elongation, G1 to S cell cycle control, G1/S Transition, G1/S-Specific Transcription, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: O75419
Entrez ID: 8318
|
Does Knockout of TMEM41A in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
TMEM41A
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TMEM41A (transmembrane protein 41A)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q96HV5
Entrez ID: 90407
|
Does Knockout of CCDC112 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
CCDC112
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: CCDC112 (coiled-coil domain containing 112)
Type: protein-coding
Summary: Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: centriolar satellite, cytoplasm, cytoskeleton
Pathways:
UniProt: Q8NEF3
Entrez ID: 153733
|
Does Knockout of DMAP1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
DMAP1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: DMAP1 (DNA methyltransferase 1 associated protein 1)
Type: protein-coding
Summary: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of protein import into nucleus, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, response to ethanol; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, transcription corepressor activity; CC: NuA4 histone acetyltransferase complex, Swr1 complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleosome, nucleus, replication fork
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9NPF5
Entrez ID: 55929
|
Does Knockout of CXCL11 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
CXCL11
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: CXCL11 (C-X-C motif chemokine ligand 11)
Type: protein-coding
Summary: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: T cell chemotaxis, adenylate cyclase-activating G protein-coupled receptor signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, cell-cell signaling, chemokine-mediated signaling pathway, chemotaxis, defense response, immune response, inflammatory response, killing of cells of another organism, positive regulation of release of sequestered calcium ion into cytosol, regulation of cell population proliferation, signal transduction; MF: CXCR3 chemokine receptor binding, chemokine activity, cytokine activity, heparin binding, protein binding; CC: extracellular region, extracellular space
Pathways: Allograft Rejection, CXCR3-mediated signaling events, Chemokine receptors bind chemokines, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Homo sapiens (human), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide ligand-binding receptors, Regulation of toll-like receptor signaling pathway, SARS-CoV-2 innate immunity evasion and cell-specific immune response, Signal Transduction, Signaling by GPCR, Toll-like Receptor Signaling Pathway, Toll-like receptor signaling pathway - Homo sapiens (human), Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: O14625
Entrez ID: 6373
|
Does Knockout of TRIM49 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
TRIM49
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: TRIM49 (tripartite motif containing 49)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: innate immune response, regulation of gene expression; MF: metal ion binding, protein binding, protein kinase binding, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: P0CI25
Entrez ID: 57093
|
Does Knockout of MAGOH in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
MAGOH
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: MAGOH (mago homolog, exon junction complex subunit)
Type: protein-coding
Summary: Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of alternative mRNA splicing, via spliceosome, regulation of mRNA processing, regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translation; MF: RNA binding, protein binding; CC: catalytic step 2 spliceosome, cytoplasm, cytosol, exon-exon junction complex, exon-exon junction subcomplex mago-y14, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Axon guidance, Developmental Biology, Gene expression (Transcription), Metabolism of RNA, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, RNA transport - Homo sapiens (human), Regulation of expression of SLITs and ROBOs, Signaling by ROBO receptors, Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Homo sapiens (human)
UniProt: P61326
Entrez ID: 4116
|
Does Knockout of KLRC4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
KLRC4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: KLRC4 (killer cell lectin like receptor C4)
Type: protein-coding
Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: positive regulation of natural killer cell mediated cytotoxicity, stimulatory C-type lectin receptor signaling pathway; CC: external side of plasma membrane, membrane
Pathways: Antigen processing and presentation - Homo sapiens (human), ras-independent pathway in nk cell-mediated cytotoxicity
UniProt: O43908
Entrez ID: 8302
|
Does Knockout of NSA2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
NSA2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NSA2 (NSA2 ribosome biogenesis factor)
Type: protein-coding
Summary: This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis; CC: nucleolus, nucleus, preribosome, preribosome, large subunit precursor, ribonucleoprotein complex
Pathways:
UniProt: O95478
Entrez ID: 10412
|
Does Knockout of MON1B in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
MON1B
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: MON1B (MON1 vesicular trafficking associated B)
Type: protein-coding
Summary: Involved in early viral transcription and late viral transcription. Located in cytoplasm. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: early viral transcription, late viral transcription, protein targeting to vacuole, vesicle-mediated transport; CC: Mon1-Ccz1 complex, cytoplasm
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q7L1V2
Entrez ID: 22879
|
Does Knockout of WDR3 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
WDR3
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: WDR3 (WD repeat domain 3)
Type: protein-coding
Summary: This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: maturation of SSU-rRNA, ribosomal small subunit biogenesis; MF: RNA binding, snoRNA binding; CC: Pwp2p-containing subcomplex of 90S preribosome, nuclear membrane, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9UNX4
Entrez ID: 10885
|
Does Knockout of MIR3913-1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
MIR3913-1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: MIR3913-1 (microRNA 3913-1)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100500903
|
Does Knockout of EBI3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
EBI3
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: EBI3 (Epstein-Barr virus induced 3)
Type: protein-coding
Summary: This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008].
Gene Ontology: BP: T cell proliferation, T-helper 1 type immune response, cytokine-mediated signaling pathway, humoral immune response, immune system process, positive regulation of alpha-beta T cell proliferation, positive regulation of type II interferon production, signal transduction; MF: cytokine activity, cytokine receptor activity, interleukin-27 receptor binding, protein binding; CC: endoplasmic reticulum lumen, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), IL27-mediated signaling events, Immune System, Interleukin-12 family signaling, Interleukin-27 signaling, Interleukin-35 Signalling, Signaling by Interleukins
UniProt: Q14213
Entrez ID: 10148
|
Does Knockout of GABPB1 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
GABPB1
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: GABPB1 (GA binding protein transcription factor subunit beta 1)
Type: protein-coding
Summary: This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrion organization, positive regulation of transcription by RNA polymerase II; MF: protein binding, transcription cis-regulatory region binding; CC: cytoplasmic ribonucleoprotein granule, nucleoplasm, nucleus
Pathways: Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex, Mitochondrial Gene Expression, Mitochondrial biogenesis, Myometrial relaxation and contraction pathways, Organelle biogenesis and maintenance, Transcriptional activation of mitochondrial biogenesis
UniProt: Q06547
Entrez ID: 2553
|
Does Knockout of RCBTB2 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
RCBTB2
|
response to virus
|
Lung Cancer Cell Line
|
Gene: RCBTB2 (RCC1 and BTB domain containing protein 2)
Type: protein-coding
Summary: This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].
Gene Ontology: BP: cell population proliferation, digestive tract development, liver development, lymph node development, spleen development; MF: guanyl-nucleotide exchange factor activity, protein binding; CC: acrosomal vesicle, cytoplasm, cytoplasmic vesicle
Pathways:
UniProt: O95199
Entrez ID: 1102
|
Does Knockout of ZNF619 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
ZNF619
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ZNF619 (zinc finger protein 619)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q8N2I2
Entrez ID: 285267
|
Does Knockout of PSMA6 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
PSMA6
|
cell proliferation
|
T-lymphoma cell line
|
Gene: PSMA6 (proteasome 20S subunit alpha 6)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: positive regulation of canonical NF-kappaB signal transduction, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, regulation of inflammatory response, ubiquitin-dependent protein catabolic process; MF: NF-kappaB binding, RNA binding, endopeptidase activity, protein binding, purine ribonucleoside triphosphate binding; CC: P-body, cilium, cytoplasm, cytosol, extracellular exosome, mitochondrion, myofibril, nuclear matrix, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, ribosome, sarcomere
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: P60900
Entrez ID: 5687
|
Does Knockout of TRAPPC11 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
TRAPPC11
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TRAPPC11 (trafficking protein particle complex subunit 11)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: COPII vesicle coating, Golgi organization, constitutive secretory pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, regulation of protein complex stability, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TRAPP complex, TRAPPIII protein complex, cytoplasm, cytosol
Pathways: Genes related to primary cilium development (based on CRISPR), Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q7Z392
Entrez ID: 60684
|
Does Knockout of SMG6 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
SMG6
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SMG6 (SMG6 nonsense mediated mRNA decay factor)
Type: protein-coding
Summary: This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: mRNA export from nucleus, negative regulation of telomere capping, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of dephosphorylation, regulation of telomere maintenance, regulation of telomere maintenance via telomerase; MF: DNA binding, DNA polymerase binding, RNA binding, RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, protein binding, ribonucleoprotein complex binding, telomerase RNA binding, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, ciliary basal body, cytoplasm, cytosol, exon-exon junction complex, nucleolus, nucleus, plasma membrane, telomerase holoenzyme complex
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Regulation of Telomerase, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q86US8
Entrez ID: 23293
|
Does Knockout of PABPC1L2A in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
PABPC1L2A
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: PABPC1L2A (poly(A) binding protein cytoplasmic 1 like 2A)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, mRNA 3'-UTR binding, nucleic acid binding, poly(A) binding, poly(U) RNA binding; CC: cytoplasmic stress granule, cytosol, extracellular exosome, nucleus, ribonucleoprotein complex
Pathways: RNA degradation - Homo sapiens (human), RNA transport - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q5JQF8
Entrez ID: 340529
|
Does Knockout of BACH1 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
BACH1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: BACH1 (BTB domain and CNC homolog 1)
Type: protein-coding
Summary: This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009].
Gene Ontology: BP: DNA repair, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, heme binding, ligand-modulated transcription factor activity, protein binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Heme signaling, Integrated Cancer Pathway, KEAP1-NFE2L2 pathway, NFE2L2 regulating anti-oxidant/detoxification enzymes, Nuclear events mediated by NFE2L2, Regulation of BACH1 activity, Regulation of HMOX1 expression and activity
UniProt: O14867
Entrez ID: 571
|
Does Knockout of TBC1D3H in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
TBC1D3H
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TBC1D3H (TBC1 domain family member 3H)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase activator activity; CC: endosome, membrane, plasma membrane
Pathways:
UniProt: P0C7X1
Entrez ID: 729877
|
Does Knockout of ACAA1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
ACAA1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: ACAA1 (acetyl-CoA acyltransferase 1)
Type: protein-coding
Summary: This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: alpha-linolenic acid metabolic process, bile acid metabolic process, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA oxidase, fatty acid metabolic process, lipid metabolic process, phenylacetate catabolic process, very long-chain fatty acid metabolic process; MF: acetate CoA-transferase activity, acetyl-CoA C-acetyltransferase activity, acetyl-CoA C-acyltransferase activity, acetyl-CoA C-myristoyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, long-chain fatty acyl-CoA oxidase activity, protein binding, transferase activity; CC: cytosol, extracellular region, membrane, peroxisomal matrix, peroxisome, specific granule lumen
Pathways: Amino Acid metabolism, Beta-oxidation of very long chain fatty acids, Biosynthesis of unsaturated fatty acids - Homo sapiens (human), Eicosanoid metabolism via cyclooxygenases (COX), Eicosanoid metabolism via lipooxygenases (LOX), Fatty acid degradation - Homo sapiens (human), Fatty acid metabolism, Immune System, Innate Immune System, Metabolism, Metabolism of lipids, Neutrophil degranulation, Nuclear Receptors Meta-Pathway, PPAR signaling pathway, PPAR signaling pathway - Homo sapiens (human), PPAR-alpha pathway, Peroxisomal lipid metabolism, Peroxisomal protein import, Peroxisome - Homo sapiens (human), Protein localization, TYSND1 cleaves peroxisomal proteins, Valine, leucine and isoleucine degradation - Homo sapiens (human), alpha-Linolenic acid metabolism - Homo sapiens (human), alpha-linolenic (omega3) and linoleic (omega6) acid metabolism, alpha-linolenic acid (ALA) metabolism, fatty acid β-oxidation, fatty acid β-oxidation (peroxisome)
UniProt: P09110
Entrez ID: 30
|
Does Knockout of ERC2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
ERC2
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: ERC2 (ELKS/RAB6-interacting/CAST family member 2)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the Rab3-interacting molecule (RIM)-binding protein family. Members of this protein family form part of the cytomatrix at the active zone (CAZ) complex and function as regulators of neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: maintenance of presynaptic active zone structure, regulation of calcium-dependent activation of synaptic vesicle fusion, regulation of presynaptic cytosolic calcium ion concentration, synaptic vesicle priming; MF: protein binding, structural constituent of presynaptic active zone; CC: GABA-ergic synapse, cell projection, cytoplasm, cytoskeleton, glutamatergic synapse, growth cone, presynapse, presynaptic active zone, presynaptic active zone cytoplasmic component, presynaptic membrane, synapse
Pathways: Exercise-induced Circadian Regulation
UniProt: O15083
Entrez ID: 26059
|
Does Knockout of KLHL21 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
KLHL21
|
cell proliferation
|
Cancer Cell Line
|
Gene: KLHL21 (kelch like family member 21)
Type: protein-coding
Summary: Enables cullin family protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in chromosome passenger complex localization to spindle midzone; protein ubiquitination; and regulation of cytokinesis. Located in polar microtubule. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, chromosome passenger complex localization to spindle midzone, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, regulation of cytokinesis; MF: cullin family protein binding, protein binding, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activity; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, cytoskeleton, cytosol, polar microtubule, spindle
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9UJP4
Entrez ID: 9903
|
Does Knockout of CRY2 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
CRY2
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: CRY2 (cryptochrome circadian regulator 2)
Type: protein-coding
Summary: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: blue light signaling pathway, circadian regulation of gene expression, circadian rhythm, entrainment of circadian clock by photoperiod, glucose homeostasis, lipid storage, negative regulation of DNA-templated transcription, negative regulation of circadian rhythm, negative regulation of glucocorticoid secretion, negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway, negative regulation of transcription by RNA polymerase II, photoreactive repair, protein import into nucleus, regulation of circadian rhythm, regulation of sodium-dependent phosphate transport, response to activity, response to insulin, response to light stimulus, rhythmic process; MF: DNA (6-4) photolyase activity, DNA binding, FAD binding, blue light photoreceptor activity, damaged DNA binding, deoxyribodipyrimidine photo-lyase activity, kinase binding, nuclear receptor binding, nucleotide binding, phosphatase binding, photoreceptor activity, protein binding, protein kinase binding, protein phosphatase inhibitor activity, single-stranded DNA binding, transcription cis-regulatory region binding; CC: Cry-Per complex, cytoplasm, cytosol, extracellular region, mitochondrion, nuclear speck, nucleus
Pathways: Circadian clock, Circadian rhythm - Homo sapiens (human), Circadian rhythm pathway, Degradation of CRY and PER proteins, Exercise-induced Circadian Regulation, Melatonin metabolism and effects, Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes, Phosphorylation and nuclear translocation of the CRY:PER:kinase complex, The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
UniProt: Q49AN0
Entrez ID: 1408
|
Does Knockout of UBE2N in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
UBE2N
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: UBE2N (ubiquitin conjugating enzyme E2 N)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA repair, T cell receptor signaling pathway, TORC1 signaling, antiviral innate immune response, cellular response to nutrient levels, double-strand break repair via homologous recombination, negative regulation of TORC1 signaling, positive regulation of DNA repair, positive regulation of NF-kappaB transcription factor activity, positive regulation of canonical NF-kappaB signal transduction, positive regulation of double-strand break repair, positive regulation of intracellular signal transduction, positive regulation of protein K63-linked ubiquitination, postreplication repair, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked ubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of DNA repair, ubiquitin-dependent protein catabolic process; MF: ATP binding, RNA binding, nucleotide binding, protein binding, transferase activity, ubiquitin binding, ubiquitin conjugating enzyme activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activator activity, ubiquitin-protein transferase activity; CC: UBC13-MMS2 complex, cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, protein-containing complex, ubiquitin conjugating enzyme complex, ubiquitin ligase complex
Pathways: 3q29 copy number variation syndrome, ATM pathway, Adaptive Immune System, Aggrephagy, Antigen processing: Ubiquitination & Proteasome degradation, Antiviral mechanism by IFN-stimulated genes, Autophagy, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cell Cycle, Cell Cycle Checkpoints, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Disease, Downstream TCR signaling, E3 ubiquitin ligases ubiquitinate target proteins, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of Incision Complex in GG-NER, G2/M Checkpoints, G2/M DNA damage checkpoint, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, IKK complex recruitment mediated by RIP1, IL-1 signaling pathway, IL1, IL1-mediated signaling events, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, ISG15 antiviral mechanism, Immune System, Infectious disease, Innate Immune System, Interferon Signaling, Interleukin-1 Induced Activation of NF-kappa-B, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, MAP kinase activation, Macroautophagy, Metabolism of proteins, Mitophagy, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NOD1/2 Signaling Pathway, Nonhomologous End-Joining (NHEJ), Nucleotide Excision Repair, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, PINK1-PRKN Mediated Mitophagy, Post-translational protein modification, Processing of DNA double-strand break ends, Protein ubiquitination, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Selective autophagy, Shigellosis - Homo sapiens (human), Signaling by Interleukins, Simplified Depiction of MYD88 Distinct Input-Output Pathway, TAK1-dependent IKK and NF-kappa-B activation , TCR signaling, TICAM1, RIP1-mediated IKK complex recruitment, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ubiquitin mediated proteolysis - Homo sapiens (human), Viral Infection Pathways, activated TAK1 mediates p38 MAPK activation
UniProt: P61088
Entrez ID: 7334
|
Does Knockout of INCENP in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
INCENP
|
cell proliferation
|
Bladder Carcinoma
|
Gene: INCENP (inner centromere protein)
Type: protein-coding
Summary: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell division, chromosome segregation, meiotic spindle midzone assembly, metaphase chromosome alignment, mitotic cell cycle, mitotic cytokinesis, mitotic spindle assembly, mitotic spindle midzone assembly, positive regulation of attachment of mitotic spindle microtubules to kinetochore, positive regulation of mitotic cell cycle spindle assembly checkpoint, positive regulation of mitotic cytokinesis, positive regulation of mitotic sister chromatid separation; MF: molecular function activator activity, protein binding; CC: central element, chromocenter, chromosome, chromosome passenger complex, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, lateral element, meiotic spindle midzone, microtubule, microtubule cytoskeleton, midbody, nuclear body, nucleoplasm, nucleus, pericentric heterochromatin, protein-containing complex, spindle, synaptonemal complex
Pathways: Aurora B signaling, Aurora C signaling, PLK1 signaling events, Regulation of nuclear beta catenin signaling and target gene transcription
UniProt: Q9NQS7
Entrez ID: 3619
|
Does Knockout of FAM110C in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
FAM110C
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: FAM110C (family with sequence similarity 110 member C)
Type: protein-coding
Summary: Enables alpha-tubulin binding activity. Involved in positive regulation of cell migration; positive regulation of protein kinase B signaling; and regulation of cell projection assembly. Located in cell cortex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of cell projection assembly; MF: alpha-tubulin binding, protein binding; CC: cell cortex, centrosome, cytoplasm, cytoskeleton, microtubule, nucleus, spindle pole
Pathways:
UniProt: Q1W6H9
Entrez ID: 642273
|
Does Knockout of RHOT2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
RHOT2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: RHOT2 (ras homolog family member T2)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: cellular homeostasis, mitochondrial outer membrane permeabilization, mitochondrion organization, mitochondrion transport along microtubule; MF: ATP hydrolysis activity, GDP binding, GTP binding, GTPase activity, calcium ion binding, hydrolase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding; CC: membrane, mitochondrial outer membrane, mitochondrion
Pathways: Miro GTPase Cycle, Mitophagy - animal - Homo sapiens (human), RHOT2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8IXI1
Entrez ID: 89941
|
Does Knockout of PROM1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
PROM1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: PROM1 (prominin 1)
Type: protein-coding
Summary: This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: camera-type eye photoreceptor cell differentiation, glomerular parietal epithelial cell differentiation, photoreceptor cell maintenance, podocyte differentiation, positive regulation of nephron tubule epithelial cell differentiation, retina layer formation, retina morphogenesis in camera-type eye; MF: actinin binding, cadherin binding, cholesterol binding, protein binding; CC: apical plasma membrane, cell projection, cell surface, cilium, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, extracellular space, membrane, microvillus, microvillus membrane, photoreceptor outer segment, photoreceptor outer segment membrane, plasma membrane, prominosome, vesicle
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Pancreatic Ductal Cells, Extracellular vesicle-mediated signaling in recipient cells, Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: O43490
Entrez ID: 8842
|
Does Knockout of NAP1L3 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
NAP1L3
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: NAP1L3 (nucleosome assembly protein 1 like 3)
Type: protein-coding
Summary: This gene is intronless and encodes a member of the nucleosome assembly protein (NAP) family. This gene is linked closely to a region of genes responsible for several X-linked cognitive disability syndromes. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: nucleosome assembly; MF: chromatin binding, histone binding, protein binding; CC: chromatin, nucleus
Pathways:
UniProt: Q99457
Entrez ID: 4675
|
Does Knockout of PDGFRL in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
PDGFRL
|
response to virus
|
Lung Cancer Cell Line
|
Gene: PDGFRL (platelet derived growth factor receptor like)
Type: protein-coding
Summary: This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to platelet-derived growth factor stimulus, platelet-derived growth factor receptor signaling pathway, platelet-derived growth factor receptor-beta signaling pathway; MF: platelet activating factor receptor activity, platelet-derived growth factor beta-receptor activity, platelet-derived growth factor receptor activity
Pathways:
UniProt: Q15198
Entrez ID: 5157
|
Does Knockout of SUZ12 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
SUZ12
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SUZ12 (SUZ12 polycomb repressive complex 2 subunit)
Type: protein-coding
Summary: This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: cell population proliferation, chromatin organization, facultative heterochromatin formation, negative regulation of cell differentiation, negative regulation of transcription by RNA polymerase II, oligodendrocyte differentiation, positive regulation of cell population proliferation, random inactivation of X chromosome; MF: RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, enzyme activator activity, histone H3K9me2/3 reader activity, lncRNA binding, metal ion binding, promoter-specific chromatin binding, protein binding, sequence-specific DNA binding, transcription corepressor binding, zinc ion binding; CC: ESC/E(Z) complex, RSC-type complex, chromatin silencing complex, nuclear body, nucleolus, nucleoplasm, nucleus, protein-DNA complex, ribonucleoprotein complex, sex chromatin
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Co-inhibition by PD-1, Defective pyroptosis, Developmental Biology, Disease, Diseases of programmed cell death, Epigenetic regulation of gene expression, Epithelial to mesenchymal transition in colorectal cancer, FBXL10 enhancement of MAP-ERK signaling in diffuse large B-cell lymphoma, Gene expression (Transcription), Generic Transcription Pathway, HCMV Early Events, HCMV Infection, Immune System, Infectious disease, Interactome of polycomb repressive complex 2 (PRC2), Intracellular signaling by second messengers, Metabolism of proteins, Negative Regulation of CDH1 Gene Transcription, Oxidative Stress Induced Senescence, PIP3 activates AKT signaling, PKMTs methylate histone lysines, PRC2 methylates histones and DNA, PTEN Regulation, Post-translational protein modification, RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of PTEN gene transcription, Regulation of T cell activation by CD28 family, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of chromatin organization proteins, Signal Transduction, Transcriptional Regulation by E2F6, Tumor suppressor activity of SMARCB1, Viral Infection Pathways, the prc2 complex sets long-term gene silencing through modification of histone tails
UniProt: Q15022
Entrez ID: 23512
|
Does Knockout of NDUFB2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
NDUFB2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: NDUFB2 (NADH:ubiquinone oxidoreductase subunit B2)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human)
UniProt: O95178
Entrez ID: 4708
|
Does Knockout of YWHAE in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
YWHAE
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon)
Type: protein-coding
Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: Golgi to plasma membrane transport, MAPK cascade, cellular response to heat, cerebral cortex development, cytoplasmic pattern recognition receptor signaling pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, hippo signaling, hippocampus development, intracellular potassium ion homeostasis, intracellular protein localization, intracellular signal transduction, membrane repolarization during cardiac muscle cell action potential, negative regulation of calcium ion export across plasma membrane, negative regulation of toll-like receptor signaling pathway, neuron migration, positive regulation of hippo signaling, positive regulation of protein export from nucleus, positive regulation of toll-like receptor signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein localization to endoplasmic reticulum, protein localization to nucleus, protein targeting, regulation of cytosolic calcium ion concentration, regulation of heart rate by cardiac conduction, regulation of heart rate by hormone, regulation of membrane repolarization, regulation of mitotic cell cycle, regulation of potassium ion transmembrane transport, signal transduction, substantia nigra development, toll-like receptor 4 signaling pathway; MF: MHC class II protein complex binding, RNA binding, cadherin binding, calcium channel inhibitor activity, calcium channel regulator activity, enzyme binding, histone deacetylase binding, identical protein binding, molecular function inhibitor activity, phosphoprotein binding, phosphoserine residue binding, potassium channel regulator activity, protein binding, protein domain specific binding, protein heterodimerization activity, protein phosphatase binding, protein phosphatase inhibitor activity, protein sequestering activity, scaffold protein binding, signaling adaptor activity, transmembrane transporter binding, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, focal adhesion, melanosome, membrane, mitochondrial membrane, nucleus, plasma membrane
Pathways: AURKA Activation by TPX2, Activation of BAD and translocation to mitochondria , Activation of BH3-only proteins, Alpha6Beta4Integrin, Anchoring of the basal body to the plasma membrane, Apoptosis, Calcium Regulation in the Cardiac Cell, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cell death signalling via NRAGE, NRIF and NADE, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Cilium Assembly, Class I PI3K signaling events mediated by Akt, Death Receptor Signaling, Defective Intrinsic Pathway for Apoptosis, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models, Developmental Biology, Disease, Diseases of programmed cell death, ErbB1 downstream signaling, FoxO family signaling, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, HSF1 activation, Hedgehog, Hepatitis C - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), IGF1 pathway, Infectious disease, Insulin-mediated glucose transport, Intrinsic Pathway for Apoptosis, LKB1 signaling events, Lissencephaly gene (LIS1) in neuronal migration and development, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MITF-M-regulated melanocyte development, Membrane Trafficking, Mitotic G2-G2/M phases, Mitotic Prometaphase, Myometrial relaxation and contraction pathways, NADE modulates death signalling, NOD-like receptor signaling pathway - Homo sapiens (human), Neurodegenerative Diseases, Neurotrophin signaling pathway - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Organelle biogenesis and maintenance, PDGFR-beta signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Programmed Cell Death, RAB GEFs exchange GTP for GDP on RABs, RHO GTPase Effectors, RHO GTPases activate PKNs, RNA Polymerase II Transcription, Rab regulation of trafficking, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of HSF1-mediated heat shock response, Regulation of PLK1 Activity at G2/M Transition, Regulation of Telomerase, Regulation of nuclear beta catenin signaling and target gene transcription, Role of Calcineurin-dependent NFAT signaling in lymphocytes, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 targets host intracellular signalling and regulatory pathways, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 targets host intracellular signalling and regulatory pathways, SARS-CoV-2-host interactions, Signal Transduction, Signaling by Hippo, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling events mediated by HDAC Class II, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, TGF-beta receptor signaling, TNFalpha, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, Transcriptional and post-translational regulation of MITF-M expression and activity, Translocation of SLC2A4 (GLUT4) to the plasma membrane, Trk receptor signaling mediated by PI3K and PLC-gamma, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), a6b1 and a6b4 Integrin signaling, mTOR signaling pathway, p38 signaling mediated by MAPKAP kinases, p75 NTR receptor-mediated signalling, p75(NTR)-mediated signaling
UniProt: P62258
Entrez ID: 7531
|
Does Knockout of VIRMA in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
VIRMA
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: VIRMA (vir like m6A methyltransferase associated)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA alternative polyadenylation and mRNA methylation. Located in cytosol and nuclear speck. Colocalizes with RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing; MF: RNA binding, protein binding; CC: RNA N6-methyladenosine methyltransferase complex, cytoplasm, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q69YN4
Entrez ID: 25962
|
Does Knockout of BMP3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
BMP3
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: BMP3 (bone morphogenetic protein 3)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: cartilage development, cell differentiation, cell surface receptor protein serine/threonine kinase signaling pathway, cell-cell signaling, negative regulation of ossification, ossification, osteoblast differentiation, positive regulation of transcription by RNA polymerase II, skeletal system development; MF: BMP receptor binding, cytokine activity, growth factor activity, signaling receptor binding; CC: extracellular exosome, extracellular region, extracellular space
Pathways: Adipogenesis, Cytokine-cytokine receptor interaction - Homo sapiens (human)
UniProt: P12645
Entrez ID: 651
|
Does Knockout of CYBRD1 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
CYBRD1
|
response to virus
|
Huh-7 Cell
|
Gene: CYBRD1 (cytochrome b reductase 1)
Type: protein-coding
Summary: This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ascorbate homeostasis, intracellular iron ion homeostasis, multicellular organismal-level iron ion homeostasis, reductive iron assimilation, response to iron ion, transmembrane transport; MF: identical protein binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on metal ions, protein binding, transmembrane ascorbate ferrireductase activity, transmembrane monodehydroascorbate reductase activity; CC: apical plasma membrane, brush border membrane, extracellular exosome, lysosomal membrane, membrane, plasma membrane
Pathways: Iron uptake and transport, Mineral absorption - Homo sapiens (human), Transport of small molecules
UniProt: Q53TN4
Entrez ID: 79901
|
Does Knockout of FUZ in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
FUZ
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: FUZ (fuzzy planar cell polarity protein)
Type: protein-coding
Summary: This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: cell projection organization, cilium assembly, embryonic body morphogenesis, embryonic skeletal system morphogenesis, establishment of planar polarity, hair follicle development, intraciliary transport, negative regulation of canonical Wnt signaling pathway, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation, negative regulation of neural crest formation, neural tube closure, neural tube development, non-motile cilium assembly, positive regulation of cilium assembly, protein transport, regulation of cilium assembly, regulation of smoothened signaling pathway, vesicle-mediated transport; MF: phosphatidylinositol binding, protein binding; CC: cell projection, cilium, cytoplasm, cytoskeleton, extracellular exosome
Pathways: Ciliary landscape, Genes related to primary cilium development (based on CRISPR), Hedgehog 'off' state, Signal Transduction, Signaling by Hedgehog
UniProt: Q9BT04
Entrez ID: 80199
|
Does Knockout of ABHD16B in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
ABHD16B
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: ABHD16B (abhydrolase domain containing 16B)
Type: protein-coding
Summary: Predicted to enable acylglycerol lipase activity; palmitoyl-(protein) hydrolase activity; and phospholipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: lipid metabolic process, monoacylglycerol catabolic process, phosphatidylserine catabolic process; MF: hydrolase activity, monoacylglycerol lipase activity, phospholipase activity
Pathways:
UniProt: Q9H3Z7
Entrez ID: 140701
|
Does Knockout of TMEM242 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
TMEM242
|
cell proliferation
|
Melanoma Cell Line
|
Gene: TMEM242 (transmembrane protein 242)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9NWH2
Entrez ID: 729515
|
Does Knockout of MYH8 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
MYH8
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MYH8 (myosin heavy chain 8)
Type: protein-coding
Summary: Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is predominantly expressed in fetal skeletal muscle. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: ATP metabolic process, muscle contraction, muscle filament sliding, skeletal muscle contraction; MF: ATP binding, ATP hydrolysis activity, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, microfilament motor activity, myosin light chain binding, myosin phosphatase activity, nucleotide binding, structural constituent of muscle; CC: cytoplasm, cytosol, muscle myosin complex, myofibril, myosin II complex, myosin complex, myosin filament, sarcomere
Pathways: Muscle contraction, Striated Muscle Contraction, Striated Muscle Contraction Pathway
UniProt: P13535
Entrez ID: 4626
|
Does Knockout of SYNPR in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
SYNPR
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: SYNPR (synaptoporin)
Type: protein-coding
Summary: Predicted to be located in neuron projection and synaptic vesicle. Predicted to be integral component of membrane. Predicted to be active in synaptic vesicle membrane. Predicted to be integral component of synaptic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasmic vesicle, membrane, neuron projection, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways:
UniProt: Q8TBG9
Entrez ID: 132204
|
Does Knockout of BCL9 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
BCL9
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: BCL9 (BCL9 transcription coactivator)
Type: protein-coding
Summary: BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Wnt signaling pathway, canonical Wnt signaling pathway, myoblast differentiation, myotube differentiation involved in skeletal muscle regeneration, positive regulation of transcription by RNA polymerase II, regulation of transforming growth factor beta receptor signaling pathway, skeletal muscle cell differentiation, somatic stem cell population maintenance, transcription by RNA polymerase II; MF: beta-catenin binding, protein binding, transcription coactivator activity; CC: Golgi apparatus, beta-catenin-TCF complex, cis-Golgi network, cytoplasm, nucleoplasm, nucleus, sarcoplasm
Pathways: 1q21.1 copy number variation syndrome, Deactivation of the beta-catenin transactivating complex, Formation of the beta-catenin:TCF transactivating complex, Regulation of nuclear beta catenin signaling and target gene transcription, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt, Wnt Signaling Pathway, Wnt-beta-catenin signaling pathway in leukemia
UniProt: O00512
Entrez ID: 607
|
Does Knockout of GMNN in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
GMNN
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: GMNN (geminin DNA replication inhibitor)
Type: protein-coding
Summary: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: DNA replication preinitiation complex assembly, animal organ morphogenesis, negative regulation of DNA replication, negative regulation of DNA-templated DNA replication, negative regulation of DNA-templated transcription, negative regulation of cell cycle, positive regulation of chromatin binding, protein-containing complex assembly, regulation of DNA replication, regulation of DNA-templated DNA replication initiation, regulation of mitotic cell cycle; MF: DNA-binding transcription factor binding, chromatin binding, histone deacetylase binding, protein binding, transcription corepressor activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, transcription repressor complex
Pathways: Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, Mitotic G1 phase and G1/S transition, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: O75496
Entrez ID: 51053
|
Does Knockout of ARC in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
ARC
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: ARC (activity regulated cytoskeleton associated protein)
Type: protein-coding
Summary: Predicted to enable mRNA binding activity. Involved in cell migration; cytoskeleton organization; and regulation of cell morphogenesis. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: anterior/posterior pattern specification, cell migration, cytoskeleton organization, dendritic spine morphogenesis, endocytosis, endoderm development, long-term memory, long-term synaptic potentiation, mRNA transport, modulation of chemical synaptic transmission, protein homooligomerization, regulation of cell morphogenesis, regulation of dendritic spine morphogenesis, regulation of long-term synaptic depression, regulation of long-term synaptic potentiation, regulation of neuronal synaptic plasticity, regulation of postsynaptic neurotransmitter receptor internalization, vesicle-mediated intercellular transport; MF: RNA binding, mRNA binding, protein binding, structural molecule activity; CC: acrosomal vesicle, actin cytoskeleton, cell cortex, cell projection, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, dendrite, dendritic spine, early endosome membrane, endosome, extracellular vesicle, glutamatergic synapse, membrane, membrane raft, neuronal cell body, neuronal ribonucleoprotein granule, plasma membrane, postsynaptic density, postsynaptic membrane, synapse, virus-like capsid
Pathways: Amphetamine addiction - Homo sapiens (human), BDNF-TrkB Signaling, Disruption of postsynaptic signaling by CNV, Fragile X Syndrome, NGF-stimulated transcription, Nuclear Events (kinase and transcription factor activation), Serotonin and anxiety, Serotonin and anxiety-related events, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Synaptic signaling pathways associated with autism spectrum disorder
UniProt: Q7LC44
Entrez ID: 23237
|
Does Knockout of GTF2H2 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
GTF2H2
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: GTF2H2 (general transcription factor IIH subunit 2)
Type: protein-coding
Summary: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, G protein-coupled receptor internalization, nucleotide-excision repair, regulation of transcription by RNA polymerase II, response to UV, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: RNA polymerase II general transcription initiation factor activity, metal ion binding, protein binding, zinc ion binding; CC: core TFIIH complex portion of holo TFIIH complex, nuclear speck, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: AndrogenReceptor, Basal transcription factors - Homo sapiens (human), DNA Repair, DNA Repair Pathways Full Network, Disease, Dual Incision in GG-NER, Dual incision in TC-NER, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Validated targets of C-MYC transcriptional repression, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), mRNA Capping
UniProt: Q13888
Entrez ID: 2966
|
Does Knockout of DEFB108B in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
DEFB108B
|
cell proliferation
|
T-lymphoma cell line
|
Gene: DEFB108B (defensin beta 108B)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. A pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: defense response, defense response to bacterium, innate immune response
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q8NET1
Entrez ID: 245911
|
Does Knockout of VPREB1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
VPREB1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: VPREB1 (V-set pre-B cell surrogate light chain 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology: CC: endoplasmic reticulum, extracellular region, immunoglobulin complex
Pathways: Cell surface interactions at the vascular wall, Hemostasis
UniProt: P12018
Entrez ID: 7441
|
Does Knockout of THOC3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
THOC3
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: THOC3 (THO complex subunit 3)
Type: protein-coding
Summary: This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013].
Gene Ontology: BP: RNA splicing, mRNA export from nucleus, mRNA processing, mRNA transport; CC: THO complex part of transcription export complex, chromosome, telomeric region, nuclear speck, nucleoplasm, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, RNA transport - Homo sapiens (human), Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q96J01
Entrez ID: 84321
|
Does Knockout of SUZ12 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
SUZ12
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: SUZ12 (SUZ12 polycomb repressive complex 2 subunit)
Type: protein-coding
Summary: This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: cell population proliferation, chromatin organization, facultative heterochromatin formation, negative regulation of cell differentiation, negative regulation of transcription by RNA polymerase II, oligodendrocyte differentiation, positive regulation of cell population proliferation, random inactivation of X chromosome; MF: RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, enzyme activator activity, histone H3K9me2/3 reader activity, lncRNA binding, metal ion binding, promoter-specific chromatin binding, protein binding, sequence-specific DNA binding, transcription corepressor binding, zinc ion binding; CC: ESC/E(Z) complex, RSC-type complex, chromatin silencing complex, nuclear body, nucleolus, nucleoplasm, nucleus, protein-DNA complex, ribonucleoprotein complex, sex chromatin
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Co-inhibition by PD-1, Defective pyroptosis, Developmental Biology, Disease, Diseases of programmed cell death, Epigenetic regulation of gene expression, Epithelial to mesenchymal transition in colorectal cancer, FBXL10 enhancement of MAP-ERK signaling in diffuse large B-cell lymphoma, Gene expression (Transcription), Generic Transcription Pathway, HCMV Early Events, HCMV Infection, Immune System, Infectious disease, Interactome of polycomb repressive complex 2 (PRC2), Intracellular signaling by second messengers, Metabolism of proteins, Negative Regulation of CDH1 Gene Transcription, Oxidative Stress Induced Senescence, PIP3 activates AKT signaling, PKMTs methylate histone lysines, PRC2 methylates histones and DNA, PTEN Regulation, Post-translational protein modification, RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of PTEN gene transcription, Regulation of T cell activation by CD28 family, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of chromatin organization proteins, Signal Transduction, Transcriptional Regulation by E2F6, Tumor suppressor activity of SMARCB1, Viral Infection Pathways, the prc2 complex sets long-term gene silencing through modification of histone tails
UniProt: Q15022
Entrez ID: 23512
|
Does Knockout of KDM7A in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
KDM7A
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: KDM7A (lysine demethylase 7A)
Type: protein-coding
Summary: Enables histone demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Involved in histone lysine demethylation. Located in nucleolus and nucleoplasm. Implicated in melanoma. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, chromatin remodeling, midbrain development, nervous system development, positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: 2-oxoglutarate-dependent dioxygenase activity, dioxygenase activity, histone H3K27me2/H3K27me3 demethylase activity, histone H3K36 demethylase activity, histone H3K9 demethylase activity, histone H3K9me/H3K9me2 demethylase activity, histone H4K20 demethylase activity, histone demethylase activity, iron ion binding, metal ion binding, oxidoreductase activity, transcription coregulator activity, zinc ion binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Disease, Diseases of signal transduction by growth factor receptors and second messengers, HDMs demethylate histones, Oncogenic MAPK signaling, Signaling by BRAF and RAF1 fusions
UniProt: Q6ZMT4
Entrez ID: 80853
|
Does Knockout of MTMR11 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
MTMR11
|
cell proliferation
|
Cancer Cell Line
|
Gene: MTMR11 (myotubularin related protein 11)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol-3-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, extracellular exosome, membrane
Pathways:
UniProt: A4FU01
Entrez ID: 10903
|
Does Knockout of KCNK6 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
KCNK6
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: KCNK6 (potassium two pore domain channel subfamily K member 6)
Type: protein-coding
Summary: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of systemic arterial blood pressure, positive regulation of NLRP3 inflammasome complex assembly, potassium ion transmembrane transport, potassium ion transport, regulation of lysosome size, regulation of resting membrane potential, regulation of systemic arterial blood pressure; MF: inward rectifier potassium channel activity, metal ion binding, outward rectifier potassium channel activity, potassium channel activity, potassium ion leak channel activity; CC: endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, monoatomic ion channel complex, plasma membrane, voltage-gated potassium channel complex
Pathways: Cardiac conduction, Muscle contraction, Neuronal System, Phase 4 - resting membrane potential, Potassium Channels, Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK), Tandem pore domain potassium channels
UniProt: Q9Y257
Entrez ID: 9424
|
Does Knockout of IST1 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
IST1
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: IST1 (IST1 factor associated with ESCRT-III)
Type: protein-coding
Summary: This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: ESCRT III complex disassembly, cell division, collateral sprouting, cytoskeleton-dependent cytokinesis, establishment of protein localization, intracellular protein localization, midbody abscission, multivesicular body assembly, positive regulation of collateral sprouting, positive regulation of proteolysis, protein transport; MF: MIT domain binding, cadherin binding, identical protein binding, protein binding, protein domain specific binding, protein-containing complex binding; CC: Flemming body, azurophil granule lumen, centrosome, chromatin, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, extracellular region, midbody, nuclear envelope, nucleus
Pathways: Endocytosis - Homo sapiens (human)
UniProt: P53990
Entrez ID: 9798
|
Does Knockout of U2AF2 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
U2AF2
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: U2AF2 (U2 small nuclear RNA auxiliary factor 2)
Type: protein-coding
Summary: U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, negative regulation of mRNA splicing, via spliceosome, negative regulation of protein ubiquitination, positive regulation of RNA splicing, spliceosomal complex assembly; MF: C2H2 zinc finger domain binding, RNA binding, enzyme binding, molecular function inhibitor activity, nucleic acid binding, poly-pyrimidine tract binding, pre-mRNA 3'-splice site binding, protein binding; CC: Prp19 complex, U2-type prespliceosome, U2AF complex, commitment complex, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Spliceosome - Homo sapiens (human), mRNA Processing, spliceosomal assembly
UniProt: P26368
Entrez ID: 11338
|
Does Knockout of ADM in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
ADM
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ADM (adrenomedullin)
Type: protein-coding
Summary: The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: G protein-coupled receptor internalization, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adrenomedullin receptor signaling pathway, antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, branching involved in labyrinthine layer morphogenesis, calcitonin family receptor signaling pathway, cell population proliferation, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, developmental growth, heart development, inflammatory response, negative regulation of vascular permeability, negative regulation of vasoconstriction, neural tube closure, positive regulation of angiogenesis, positive regulation of cell population proliferation, positive regulation of heart rate, positive regulation of progesterone biosynthetic process, positive regulation of vasculogenesis, receptor internalization, regulation of systemic arterial blood pressure, regulation of urine volume, response to yeast, signal transduction, vascular associated smooth muscle cell development, vasculogenesis; MF: adrenomedullin receptor binding, hormone activity, receptor ligand activity, signaling receptor binding; CC: cytoplasm, extracellular region, extracellular space, secretory granule lumen
Pathways: Calcitonin-like ligand receptors, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Class B/2 (Secretin family receptors), Complement system, G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, HIF-1-alpha transcription factor network, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Myometrial relaxation and contraction pathways, Neuroactive ligand-receptor interaction - Homo sapiens (human), Response of endothelial cells to shear stress, Signal Transduction, Signaling by GPCR, Vascular smooth muscle contraction - Homo sapiens (human)
UniProt: P35318
Entrez ID: 133
|
Does Knockout of EIF4EBP2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
EIF4EBP2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2)
Type: protein-coding
Summary: This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: TOR signaling, insulin receptor signaling pathway, memory, modulation of chemical synaptic transmission, negative regulation of translation, negative regulation of translational initiation, regulation of synaptic plasticity, regulation of translation, social behavior, translation; MF: eukaryotic initiation factor 4E binding, protein binding, translation repressor activity; CC: cytoplasm, neuronal ribonucleoprotein granule, nucleus, postsynapse
Pathways: Fragile X Syndrome, Longevity regulating pathway - multiple species - Homo sapiens (human), RNA transport - Homo sapiens (human), Translation Factors
UniProt: Q13542
Entrez ID: 1979
|
Does Knockout of ARFGEF1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
ARFGEF1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ARFGEF1 (ARF guanine nucleotide exchange factor 1)
Type: protein-coding
Summary: ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: Golgi organization, endomembrane system organization, exocytosis, negative regulation of GTPase activity, negative regulation of actin filament polymerization, neuron projection development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of wound healing, protein glycosylation, protein transport, regulation of ARF protein signal transduction, regulation of establishment of cell polarity; MF: GTPase activator activity, guanyl-nucleotide exchange factor activity, myosin binding, protein binding, protein kinase A regulatory subunit binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, membrane, nuclear matrix, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, small nuclear ribonucleoprotein complex, trans-Golgi network
Pathways: Endocytosis - Homo sapiens (human), adp-ribosylation factor, thrombin signaling and protease-activated receptors
UniProt: Q9Y6D6
Entrez ID: 10565
|
Does Knockout of TMEM168 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
TMEM168
|
response to virus
|
Lung Cancer Cell Line
|
Gene: TMEM168 (transmembrane protein 168)
Type: protein-coding
Summary: Located in transport vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, nuclear membrane, nucleus, transport vesicle
Pathways:
UniProt: Q9H0V1
Entrez ID: 64418
|
Does Knockout of XYLT2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
XYLT2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: XYLT2 (xylosyltransferase 2)
Type: protein-coding
Summary: The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: chondroitin sulfate proteoglycan biosynthetic process, glycoprotein biosynthetic process, glycosaminoglycan biosynthetic process, glycosaminoglycan metabolic process, heparan sulfate proteoglycan biosynthetic process, heparin proteoglycan biosynthetic process, proteoglycan biosynthetic process; MF: UDP-glycosyltransferase activity, glycosyltransferase activity, magnesium ion binding, manganese ion binding, metal ion binding, protein xylosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, extracellular region, extracellular space, membrane
Pathways: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human), Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human), Glycosaminoglycan metabolism, Glycosaminoglycan-protein linkage region biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Proteoglycan biosynthesis, chondroitin sulfate biosynthesis, dermatan sulfate biosynthesis, glycoaminoglycan-protein linkage region biosynthesis, heparan sulfate biosynthesis
UniProt: Q9H1B5
Entrez ID: 64132
|
Does Knockout of DNAJC7 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
DNAJC7
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7)
Type: protein-coding
Summary: This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: protein folding, regulation of cellular response to heat; MF: ATPase activator activity, heat shock protein binding, protein binding; CC: cytoplasm, cytoskeleton, cytosol, extracellular exosome, membrane, nucleoplasm, nucleus
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Constitutive Androstane Receptor Pathway, Nuclear Receptors Meta-Pathway, Pregnane X receptor pathway, Regulation of HSF1-mediated heat shock response
UniProt: Q99615
Entrez ID: 7266
|
Does Knockout of XPOT in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
XPOT
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: XPOT (exportin for tRNA)
Type: protein-coding
Summary: This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: intracellular protein transport, nucleocytoplasmic transport, tRNA export from nucleus, tRNA re-export from nucleus; MF: RNA binding, protein binding, small GTPase binding, tRNA binding; CC: cytoplasm, cytosol, nuclear matrix, nuclear pore, nucleoplasm, nucleus
Pathways: Metabolism of RNA, RNA transport - Homo sapiens (human), tRNA processing, tRNA processing in the nucleus
UniProt: O43592
Entrez ID: 11260
|
Does Knockout of C1QTNF3 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
C1QTNF3
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: C1QTNF3 (C1q and TNF related 3)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in several processes, including cellular triglyceride homeostasis; negative regulation of NIK/NF-kappaB signaling; and regulation of cytokine production. Acts upstream of or within negative regulation of gluconeogenesis. Located in extracellular exosome and membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chemical homeostasis, fat cell differentiation, intracellular triglyceride homeostasis, negative regulation of gene expression, negative regulation of gluconeogenesis, negative regulation of inflammatory response, negative regulation of interleukin-6 production, negative regulation of monocyte chemotactic protein-1 production, negative regulation of non-canonical NF-kappaB signal transduction, positive regulation of adiponectin secretion, positive regulation of cytokine production, regulation of intracellular signal transduction; MF: identical protein binding, protein binding; CC: collagen trimer, extracellular exosome, extracellular region, membrane
Pathways:
UniProt: Q9BXJ4
Entrez ID: 114899
|
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