prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of EDARADD in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | EDARADD | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: EDARADD (EDAR associated via death domain)
Type: protein-coding
Summary: This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-con... |
Does Knockout of SLC3A1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | SLC3A1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SLC3A1 (solute carrier family 3 member 1)
Type: protein-coding
Summary: This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deleti... |
Does Knockout of TPR in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | TPR | cell proliferation | Colonic Cancer Cell Line | Gene: TPR (translocated promoter region, nuclear basket protein)
Type: protein-coding
Summary: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC... |
Does Knockout of LMF1 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | LMF1 | cell proliferation | Neuroblastoma Cell Line | Gene: LMF1 (lipase maturation factor 1)
Type: protein-coding
Summary: Involved in triglyceride metabolic process. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Implicated in familial lipase maturation factor 1 deficiency. [provided by Alliance ... |
Does Knockout of EMC6 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | EMC6 | cell proliferation | Monocytic Leukemia Cell Line | Gene: EMC6 (ER membrane protein complex subunit 6)
Type: protein-coding
Summary: Contributes to membrane insertase activity. Involved in autophagosome assembly; protein insertion into ER membrane by stop-transfer membrane-anchor sequence; and tail-anchored membrane protein insertion into ER membrane. Is... |
Does Knockout of RPP14 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | RPP14 | cell proliferation | Ovarian Cancer Cell Line | Gene: RPP14 (ribonuclease P/MRP subunit p14)
Type: protein-coding
Summary: This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase ty... |
Does Knockout of ZMAT4 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | ZMAT4 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ZMAT4 (zinc finger matrin-type 4)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, identical protein binding, metal ion binding, nucleic acid b... |
Does Knockout of SEC14L5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | SEC14L5 | cell proliferation | Colonic Cancer Cell Line | Gene: SEC14L5 (SEC14 like lipid binding 5)
Type: protein-coding
Summary: Predicted to be located in mitochondrial intermembrane space. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: O43304
E... |
Does Knockout of MAP4K2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | MAP4K2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells ... |
Does Knockout of KATNB1 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | KATNB1 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: KATNB1 (katanin regulatory subunit B1)
Type: protein-coding
Summary: Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 s... |
Does Knockout of EIF2B3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | EIF2B3 | cell proliferation | Endometrial Cancer Cell Line | Gene: EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)
Type: protein-coding
Summary: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function ... |
Does Knockout of LONP2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | LONP2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: LONP2 (lon peptidase 2, peroxisomal)
Type: protein-coding
Summary: In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role i... |
Does Knockout of RPL18 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | RPL18 | cell proliferation | Melanoma Cell Line | Gene: RPL18 (ribosomal protein L18)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of NOM1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | NOM1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: NOM1 (nucleolar protein with MIF4G domain 1)
Type: protein-coding
Summary: Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA... |
Does Knockout of FABP12 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | FABP12 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: FABP12 (fatty acid binding protein 12)
Type: protein-coding
Summary: Predicted to enable lipid binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: fatty acid binding, lipid binding; CC: cytosol, nucleus
Pat... |
Does Knockout of POU1F1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | POU1F1 | cell proliferation | Colonic Cancer Cell Line | Gene: POU1F1 (POU class 1 homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this gen... |
Does Knockout of DAAM1 in Lung Cancer Cell Line causally result in response to radiation? | 1 | 1,952 | Knockout | DAAM1 | response to radiation | Lung Cancer Cell Line | Gene: DAAM1 (dishevelled associated activator of morphogenesis 1)
Type: protein-coding
Summary: Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these ... |
Does Knockout of PYROXD1 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | PYROXD1 | cell proliferation | Astrocytoma Cell Line | Gene: PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1)
Type: protein-coding
Summary: This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other prote... |
Does Knockout of DOCK1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | DOCK1 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: DOCK1 (dedicator of cytokinesis 1)
Type: protein-coding
Summary: This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase R... |
Does Knockout of BNIP3L in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | BNIP3L | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: BNIP3L (BCL2 interacting protein 3 like)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes ... |
Does Knockout of TIMM10 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | TIMM10 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: TIMM10 (translocase of inner mitochondrial membrane 10)
Type: protein-coding
Summary: The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins me... |
Does Knockout of VIRMA in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | VIRMA | cell proliferation | Medulloblastoma Cell Line | Gene: VIRMA (vir like m6A methyltransferase associated)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA alternative polyadenylation and mRNA methylation. Located in cytosol and nuclear speck. Colocalizes with RNA N6-methyladenosine methyltransferase complex. [provided by All... |
Does Knockout of SP8 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | SP8 | cell proliferation | Medulloblastoma Cell Line | Gene: SP8 (Sp8 transcription factor)
Type: protein-coding
Summary: The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. [provided ... |
Does Knockout of DCLK1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | DCLK1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: DCLK1 (doublecortin like kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization,... |
Does Knockout of ARHGDIA in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | ARHGDIA | cell proliferation | Endometrial Cancer Cell Line | Gene: ARHGDIA (Rho GDP dissociation inhibitor alpha)
Type: protein-coding
Summary: This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaini... |
Does Knockout of GABPB1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | GABPB1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: GABPB1 (GA binding protein transcription factor subunit beta 1)
Type: protein-coding
Summary: This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded prote... |
Does Knockout of CYP2A6 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | CYP2A6 | cell proliferation | Colonic Cancer Cell Line | Gene: CYP2A6 (cytochrome P450 family 2 subfamily A member 6)
Type: protein-coding
Summary: This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholest... |
Does Knockout of HECW1 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | HECW1 | response to virus | Lung Cancer Cell Line | Gene: HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane ... |
Does Knockout of CLMN in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | CLMN | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: CLMN (calmin)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in negative regulation of cell population proliferation and nuclear migration. Predicted to act upstream of or within neuron projection development. Predicted to be integral co... |
Does Knockout of PPOX in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | PPOX | cell proliferation | Neuroblastoma Cell Line | Gene: PPOX (protoporphyrinogen oxidase)
Type: protein-coding
Summary: This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disord... |
Does Knockout of EIF2B4 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | EIF2B4 | cell proliferation | Renal Cancer Cell Line | Gene: EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)
Type: protein-coding
Summary: Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta... |
Does Knockout of SREBF2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | SREBF2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SREBF2 (sterol regulatory element binding transcription factor 2)
Type: protein-coding
Summary: This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains ... |
Does Knockout of NCLN in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | NCLN | response to virus | Cervical Adenocarcinoma Cell Line | Gene: NCLN (nicalin)
Type: protein-coding
Summary: Enables ribosome binding activity. Involved in protein stabilization; regulation of protein complex stability; and regulation of protein-containing complex assembly. Located in endoplasmic reticulum membrane. Part of protein-containing complex. [provide... |
Does Knockout of PKMYT1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | PKMYT1 | cell proliferation | Medulloblastoma Cell Line | Gene: PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphory... |
Does Knockout of WDR12 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | WDR12 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: WDR12 (WD repeat domain 12)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or m... |
Does Knockout of CDC45 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | CDC45 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: CDC45 (cell division cycle 45)
Type: protein-coding
Summary: The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein comp... |
Does Knockout of TMEM41A in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | TMEM41A | cell proliferation | Monocytic Leukemia Cell Line | Gene: TMEM41A (transmembrane protein 41A)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q96HV5
Entrez ID: 90407 |
Does Knockout of CCDC112 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | CCDC112 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: CCDC112 (coiled-coil domain containing 112)
Type: protein-coding
Summary: Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: centriolar satellite, cytoplasm, cytoskeleton
Pathways:
UniProt: Q8NEF3
Entrez ID: ... |
Does Knockout of DMAP1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | DMAP1 | cell proliferation | Ovarian Cancer Cell Line | Gene: DMAP1 (DNA methyltransferase 1 associated protein 1)
Type: protein-coding
Summary: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci t... |
Does Knockout of CXCL11 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | CXCL11 | cell proliferation | Medulloblastoma Cell Line | Gene: CXCL11 (C-X-C motif chemokine ligand 11)
Type: protein-coding
Summary: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G pro... |
Does Knockout of TRIM49 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | TRIM49 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: TRIM49 (tripartite motif containing 49)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicat... |
Does Knockout of MAGOH in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | MAGOH | cell proliferation | Hepatoma Cell Line | Gene: MAGOH (mago homolog, exon junction complex subunit)
Type: protein-coding
Summary: Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mR... |
Does Knockout of KLRC4 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | KLRC4 | cell proliferation | Colonic Cancer Cell Line | Gene: KLRC4 (killer cell lectin like receptor C4)
Type: protein-coding
Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells prefe... |
Does Knockout of NSA2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | NSA2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: NSA2 (NSA2 ribosome biogenesis factor)
Type: protein-coding
Summary: This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein... |
Does Knockout of MON1B in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | MON1B | response to chemicals | Monocytic Leukemia Cell Line | Gene: MON1B (MON1 vesicular trafficking associated B)
Type: protein-coding
Summary: Involved in early viral transcription and late viral transcription. Located in cytoplasm. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: early viral transcript... |
Does Knockout of WDR3 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | WDR3 | cell proliferation | Multiple Myeloma Cell Line | Gene: WDR3 (WD repeat domain 3)
Type: protein-coding
Summary: This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD... |
Does Knockout of MIR3913-1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | MIR3913-1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: MIR3913-1 (microRNA 3913-1)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polyme... |
Does Knockout of EBI3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | EBI3 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: EBI3 (Epstein-Barr virus induced 3)
Type: protein-coding
Summary: This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa prote... |
Does Knockout of GABPB1 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | GABPB1 | cell proliferation | Neuroblastoma Cell Line | Gene: GABPB1 (GA binding protein transcription factor subunit beta 1)
Type: protein-coding
Summary: This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded prote... |
Does Knockout of RCBTB2 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | RCBTB2 | response to virus | Lung Cancer Cell Line | Gene: RCBTB2 (RCC1 and BTB domain containing protein 2)
Type: protein-coding
Summary: This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is obs... |
Does Knockout of ZNF619 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | ZNF619 | cell proliferation | Glioblastoma Cell Line | Gene: ZNF619 (zinc finger protein 619)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation ... |
Does Knockout of PSMA6 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | PSMA6 | cell proliferation | T-lymphoma cell line | Gene: PSMA6 (proteasome 20S subunit alpha 6)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 ri... |
Does Knockout of TRAPPC11 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | TRAPPC11 | cell proliferation | Colonic Cancer Cell Line | Gene: TRAPPC11 (trafficking protein particle complex subunit 11)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplas... |
Does Knockout of SMG6 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | SMG6 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SMG6 (SMG6 nonsense mediated mRNA decay factor)
Type: protein-coding
Summary: This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD... |
Does Knockout of PABPC1L2A in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | PABPC1L2A | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: PABPC1L2A (poly(A) binding protein cytoplasmic 1 like 2A)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, mRNA 3'-UTR binding, nucleic acid bindin... |
Does Knockout of BACH1 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | BACH1 | cell proliferation | Breast Cancer Cell Line | Gene: BACH1 (BTB domain and CNC homolog 1)
Type: protein-coding
Summary: This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BT... |
Does Knockout of TBC1D3H in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | TBC1D3H | cell proliferation | Monocytic Leukemia Cell Line | Gene: TBC1D3H (TBC1 domain family member 3H)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, ... |
Does Knockout of ACAA1 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | ACAA1 | cell proliferation | Colorectal Cancer Cell Line | Gene: ACAA1 (acetyl-CoA acyltransferase 1)
Type: protein-coding
Summary: This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq,... |
Does Knockout of ERC2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 1 | 1,996 | Knockout | ERC2 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: ERC2 (ELKS/RAB6-interacting/CAST family member 2)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the Rab3-interacting molecule (RIM)-binding protein family. Members of this protein family form part of the cytomatrix at the active zone (CAZ) complex and function as regula... |
Does Knockout of KLHL21 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | KLHL21 | cell proliferation | Cancer Cell Line | Gene: KLHL21 (kelch like family member 21)
Type: protein-coding
Summary: Enables cullin family protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in chromosome passenger complex localization to spindle midzone; protein ubiquitination; and regulation of cytokinesis.... |
Does Knockout of CRY2 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | CRY2 | cell proliferation | Colorectal Cancer Cell Line | Gene: CRY2 (cryptochrome circadian regulator 2)
Type: protein-coding
Summary: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but th... |
Does Knockout of UBE2N in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | UBE2N | cell proliferation | Endometrial Cancer Cell Line | Gene: UBE2N (ubiquitin conjugating enzyme E2 N)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enz... |
Does Knockout of INCENP in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | INCENP | cell proliferation | Bladder Carcinoma | Gene: INCENP (inner centromere protein)
Type: protein-coding
Summary: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive pro... |
Does Knockout of FAM110C in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | FAM110C | cell proliferation | Hepatoma Cell Line | Gene: FAM110C (family with sequence similarity 110 member C)
Type: protein-coding
Summary: Enables alpha-tubulin binding activity. Involved in positive regulation of cell migration; positive regulation of protein kinase B signaling; and regulation of cell projection assembly. Located in cell cortex. [pr... |
Does Knockout of RHOT2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | RHOT2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: RHOT2 (ras homolog family member T2)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]... |
Does Knockout of PROM1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | PROM1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: PROM1 (prominin 1)
Type: protein-coding
Summary: This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. M... |
Does Knockout of NAP1L3 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | NAP1L3 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: NAP1L3 (nucleosome assembly protein 1 like 3)
Type: protein-coding
Summary: This gene is intronless and encodes a member of the nucleosome assembly protein (NAP) family. This gene is linked closely to a region of genes responsible for several X-linked cognitive disability syndromes. [provided by R... |
Does Knockout of PDGFRL in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | PDGFRL | response to virus | Lung Cancer Cell Line | Gene: PDGFRL (platelet derived growth factor receptor like)
Type: protein-coding
Summary: This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing... |
Does Knockout of SUZ12 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | SUZ12 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SUZ12 (SUZ12 polycomb repressive complex 2 subunit)
Type: protein-coding
Summary: This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and... |
Does Knockout of NDUFB2 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | NDUFB2 | cell proliferation | Gastric Cancer Cell Line | Gene: NDUFB2 (NADH:ubiquinone oxidoreductase subunit B2)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and ... |
Does Knockout of YWHAE in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | YWHAE | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon)
Type: protein-coding
Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is... |
Does Knockout of VIRMA in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | VIRMA | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: VIRMA (vir like m6A methyltransferase associated)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA alternative polyadenylation and mRNA methylation. Located in cytosol and nuclear speck. Colocalizes with RNA N6-methyladenosine methyltransferase complex. [provided by All... |
Does Knockout of BMP3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | BMP3 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: BMP3 (bone morphogenetic protein 3)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription... |
Does Knockout of CYBRD1 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | CYBRD1 | response to virus | Huh-7 Cell | Gene: CYBRD1 (cytochrome b reductase 1)
Type: protein-coding
Summary: This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in ... |
Does Knockout of FUZ in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | FUZ | cell proliferation | Hepatoma Cell Line | Gene: FUZ (fuzzy planar cell polarity protein)
Type: protein-coding
Summary: This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associate... |
Does Knockout of ABHD16B in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | ABHD16B | RNA accumulation | Monocytic Leukemia Cell Line | Gene: ABHD16B (abhydrolase domain containing 16B)
Type: protein-coding
Summary: Predicted to enable acylglycerol lipase activity; palmitoyl-(protein) hydrolase activity; and phospholipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. L... |
Does Knockout of TMEM242 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | TMEM242 | cell proliferation | Melanoma Cell Line | Gene: TMEM242 (transmembrane protein 242)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9NWH2
... |
Does Knockout of MYH8 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | MYH8 | cell proliferation | Monocytic Leukemia Cell Line | Gene: MYH8 (myosin heavy chain 8)
Type: protein-coding
Summary: Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene e... |
Does Knockout of SYNPR in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | SYNPR | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: SYNPR (synaptoporin)
Type: protein-coding
Summary: Predicted to be located in neuron projection and synaptic vesicle. Predicted to be integral component of membrane. Predicted to be active in synaptic vesicle membrane. Predicted to be integral component of synaptic vesicle membrane. [provided by A... |
Does Knockout of BCL9 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | BCL9 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: BCL9 (BCL9 transcription coactivator)
Type: protein-coding
Summary: BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significa... |
Does Knockout of GMNN in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | GMNN | cell proliferation | Endometrial Cancer Cell Line | Gene: GMNN (geminin DNA replication inhibitor)
Type: protein-coding
Summary: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance... |
Does Knockout of ARC in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | ARC | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: ARC (activity regulated cytoskeleton associated protein)
Type: protein-coding
Summary: Predicted to enable mRNA binding activity. Involved in cell migration; cytoskeleton organization; and regulation of cell morphogenesis. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome R... |
Does Knockout of GTF2H2 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | GTF2H2 | cell proliferation | Colorectal Cancer Cell Line | Gene: GTF2H2 (general transcription factor IIH subunit 2)
Type: protein-coding
Summary: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitivene... |
Does Knockout of DEFB108B in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | DEFB108B | cell proliferation | T-lymphoma cell line | Gene: DEFB108B (defensin beta 108B)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins.... |
Does Knockout of VPREB1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | VPREB1 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: VPREB1 (V-set pre-B cell surrogate light chain 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polype... |
Does Knockout of THOC3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | THOC3 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: THOC3 (THO complex subunit 3)
Type: protein-coding
Summary: This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export compl... |
Does Knockout of SUZ12 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | SUZ12 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: SUZ12 (SUZ12 polycomb repressive complex 2 subunit)
Type: protein-coding
Summary: This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and... |
Does Knockout of KDM7A in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | KDM7A | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: KDM7A (lysine demethylase 7A)
Type: protein-coding
Summary: Enables histone demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Involved in histone lysine demethylation. Located in nucleolus and nucleoplasm. Implicated in melanoma. [provided by All... |
Does Knockout of MTMR11 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | MTMR11 | cell proliferation | Cancer Cell Line | Gene: MTMR11 (myotubularin related protein 11)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol-3-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontol... |
Does Knockout of KCNK6 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | KCNK6 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: KCNK6 (potassium two pore domain channel subfamily K member 6)
Type: protein-coding
Summary: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is s... |
Does Knockout of IST1 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | IST1 | cell proliferation | Neuroblastoma Cell Line | Gene: IST1 (IST1 factor associated with ESCRT-III)
Type: protein-coding
Summary: This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during memb... |
Does Knockout of U2AF2 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | U2AF2 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: U2AF2 (U2 small nuclear RNA auxiliary factor 2)
Type: protein-coding
Summary: U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a seq... |
Does Knockout of ADM in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | ADM | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ADM (adrenomedullin)
Type: protein-coding
Summary: The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodila... |
Does Knockout of EIF4EBP2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | EIF4EBP2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2)
Type: protein-coding
Summary: This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insu... |
Does Knockout of ARFGEF1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | ARFGEF1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ARFGEF1 (ARF guanine nucleotide exchange factor 1)
Type: protein-coding
Summary: ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. ... |
Does Knockout of TMEM168 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | TMEM168 | response to virus | Lung Cancer Cell Line | Gene: TMEM168 (transmembrane protein 168)
Type: protein-coding
Summary: Located in transport vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, nuclear membrane, nucleus, transport vesicle
Pathways:
UniProt: Q9H0V1
Entrez ID: 64... |
Does Knockout of XYLT2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | XYLT2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: XYLT2 (xylosyltransferase 2)
Type: protein-coding
Summary: The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynt... |
Does Knockout of DNAJC7 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | DNAJC7 | cell proliferation | Colorectal Cancer Cell Line | Gene: DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7)
Type: protein-coding
Summary: This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chap... |
Does Knockout of XPOT in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | XPOT | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: XPOT (exportin for tRNA)
Type: protein-coding
Summary: This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provide... |
Does Knockout of C1QTNF3 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | C1QTNF3 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: C1QTNF3 (C1q and TNF related 3)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in several processes, including cellular triglyceride homeostasis; negative regulation of NIK/NF-kappaB signaling; and regulation of cytokine production. Acts upstream of or within ne... |
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