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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of FSTL5 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
FSTL5
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: FSTL5 (follistatin like 5)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, regulation of BMP signaling pathway; MF: calcium ion binding, metal ion binding, protein binding; CC: extracellular region
Pathways:
UniProt: Q8N475
Entrez ID: 56884
|
Does Knockout of MED7 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
MED7
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: MED7 (mediator complex subunit 7)
Type: protein-coding
Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance, transcription initiation at RNA polymerase II promoter; MF: protein binding, transcription coactivator activity, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nuclear body, nucleoplasm, nucleus, transcription regulator complex, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: O43513
Entrez ID: 9443
|
Does Knockout of F13B in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
F13B
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: F13B (coagulation factor XIII B chain)
Type: protein-coding
Summary: This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: blood coagulation, blood coagulation, fibrin clot formation, hemostasis; CC: extracellular region, extracellular space, transferase complex
Pathways: Acenocoumarol Action Pathway, Alteplase Action Pathway, Aminocaproic Acid Action Pathway, Anistreplase Action Pathway, Aprotinin Action Pathway, Ardeparin Action Pathway, Argatroban Action Pathway, Bivalirudin Action Pathway, Blood Clotting Cascade, Coagulation , Common Pathway of Fibrin Clot Formation, Complement and Coagulation Cascades, Complement and coagulation cascades - Homo sapiens (human), Coronavirus disease - COVID-19 - Homo sapiens (human), Dicoumarol Action Pathway, Dicumarol Action Pathway, Enoxaparin Action Pathway, Fondaparinux Action Pathway, Formation of Fibrin Clot (Clotting Cascade), Hemostasis, Heparin Action Pathway, Lepirudin Action Pathway, Phenindione Action Pathway, Phenprocoumon Action Pathway, Reteplase Action Pathway, Steroid Biosynthesis, Streptokinase Action Pathway, Tenecteplase Action Pathway, Tranexamic Acid Action Pathway, Urokinase Action Pathway, Warfarin Action Pathway, Ximelagatran Action Pathway
UniProt: P05160
Entrez ID: 2165
|
Does Knockout of DXO in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
DXO
|
cell proliferation
|
Bladder Carcinoma
|
Gene: DXO (decapping exoribonuclease)
Type: protein-coding
Summary: This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: NAD-cap decapping, RNA destabilization, mRNA catabolic process, nuclear mRNA surveillance, nuclear-transcribed mRNA catabolic process, nucleic acid metabolic process; MF: 5'-3' exonuclease activity, RNA NAD+-cap (NAD+-forming) hydrolase activity, RNA binding, exonuclease activity, hydrolase activity, mRNA 5'-diphosphatase activity, mRNA binding, magnesium ion binding, metal ion binding, nuclease activity, nucleotide binding, protein binding; CC: cytosol, nucleoplasm, nucleus, plasma membrane
Pathways: Metabolism of RNA, Nuclear RNA decay
UniProt: O77932
Entrez ID: 1797
|
Does Knockout of TOR4A in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
TOR4A
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: TOR4A (torsin family 4 member A)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Predicted to be located in extracellular region and platelet alpha granule lumen. Predicted to be active in endoplasmic reticulum lumen and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, nucleotide binding; CC: cytoplasm, endomembrane system, endoplasmic reticulum lumen, extracellular region, membrane, nuclear envelope, platelet alpha granule lumen
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q9NXH8
Entrez ID: 54863
|
Does Knockout of NR6A1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
NR6A1
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: NR6A1 (nuclear receptor subfamily 6 group A member 1)
Type: protein-coding
Summary: This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013].
Gene Ontology: BP: gamete generation, intracellular receptor signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of mesenchymal stem cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, estrogen response element binding, metal ion binding, nuclear receptor activity, protein homodimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromatin, nucleoplasm, nucleus, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription
UniProt: Q15406
Entrez ID: 2649
|
Does Knockout of PTPN3 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
PTPN3
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: PTPN3 (protein tyrosine phosphatase non-receptor type 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
Gene Ontology: BP: MAPK cascade, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of membrane protein ectodomain proteolysis, negative regulation of mitotic cell cycle, regulation of membrane depolarization during action potential, regulation of sodium ion transmembrane transport; MF: ATPase binding, cytoskeletal protein binding, hydrolase activity, phosphoprotein phosphatase activity, phosphotyrosine residue binding, protein binding, protein tyrosine phosphatase activity, sodium channel regulator activity; CC: cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, membrane, plasma membrane
Pathways: EGFR downregulation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of MAPK pathway, RAF/MAP kinase cascade, Signal Transduction, Signaling by EGFR, Signaling by Receptor Tyrosine Kinases, TCR
UniProt: P26045
Entrez ID: 5774
|
Does Knockout of TAS2R42 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
TAS2R42
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TAS2R42 (taste 2 receptor member 42)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and sensory perception of taste. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity; CC: membrane, plasma membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Signal Transduction, Signaling by GPCR, Taste transduction - Homo sapiens (human)
UniProt: Q7RTR8
Entrez ID: 353164
|
Does Knockout of HMX3 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
HMX3
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: HMX3 (H6 family homeobox 3)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in ear development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryo implantation; maternal process involved in female pregnancy; and neuromuscular process controlling balance. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: brain development, cell differentiation, ear development, embryo implantation, inner ear morphogenesis, maternal process involved in female pregnancy, nervous system development, neuromuscular process controlling balance, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: A6NHT5
Entrez ID: 340784
|
Does Knockout of CNN2 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
CNN2
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: CNN2 (calponin 2)
Type: protein-coding
Summary: The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: actin filament organization, actomyosin structure organization, cellular response to mechanical stimulus, cytoskeleton organization, establishment of localization in cell, hemopoiesis, macrophage migration, negative regulation of macrophage migration, negative regulation of phagocytosis, phagocytosis, positive regulation of gene expression, regulation of actin filament-based process, regulation of leukocyte proliferation, regulation of mononuclear cell proliferation, wound healing; MF: actin binding, actin filament binding, cadherin binding, calmodulin binding; CC: actin cytoskeleton, cell-cell junction, cytoskeleton, extracellular region, focal adhesion, membrane, specific granule lumen, stress fiber, tertiary granule lumen
Pathways: Cytokine Signaling in Immune system, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Immune System, Innate Immune System, Interleukin-12 family signaling, Interleukin-12 signaling, Myometrial relaxation and contraction pathways, Neutrophil degranulation, Signaling by Interleukins
UniProt: Q99439
Entrez ID: 1265
|
Does Knockout of NCK1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
NCK1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: NCK1 (NCK adaptor protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: T cell activation, T cell receptor signaling pathway, actin filament organization, antiviral innate immune response, cell migration, ephrin receptor signaling pathway, lamellipodium assembly, negative regulation of PERK-mediated unfolded protein response, negative regulation of T cell receptor signaling pathway, negative regulation of insulin receptor signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of MAPK cascade, positive regulation of T cell proliferation, positive regulation of actin filament polymerization, positive regulation of cap-dependent translational initiation, positive regulation of cap-independent translational initiation, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of macromolecule biosynthetic process, positive regulation of neuron projection development, positive regulation of transcription by RNA polymerase II, positive regulation of translation in response to endoplasmic reticulum stress, regulation of cell migration, regulation of transcription by RNA polymerase II, regulation of translation, regulation of translation initiation in response to endoplasmic reticulum stress, response to endoplasmic reticulum stress, response to other organism, signal complex assembly, substrate-dependent cell migration, cell extension; MF: cadherin binding, cytoskeletal anchor activity, ephrin receptor binding, eukaryotic initiation factor eIF2 binding, molecular condensate scaffold activity, protein binding, protein domain specific binding, protein kinase inhibitor activity, protein sequestering activity, protein-macromolecule adaptor activity, receptor tyrosine kinase binding, signaling adaptor activity, signaling receptor binding, signaling receptor complex adaptor activity; CC: cell-cell junction, cytoplasm, cytosol, endoplasmic reticulum, nucleus, plasma membrane, protein phosphatase type 1 complex, ribosome, vesicle membrane
Pathways: Angiopoietin receptor Tie2-mediated signaling, Arf6 signaling events, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Axon guidance - Homo sapiens (human), B Cell Receptor Signaling Pathway, BCR, BDNF, Brain-derived neurotrophic factor (BDNF) signaling pathway, EGF-EGFR signaling pathway, EGFR1, EPHB forward signaling, ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), Genes controlling nephrogenesis, Insulin Pathway, Nephrin/Neph1 signaling in the kidney podocyte, Netrin-mediated signaling events, PDGFR-beta signaling pathway, Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Primary focal segmental glomerulosclerosis (FSGS), Prolactin, RAC1-PAK1-p38-MMP2 Pathway, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by VEGFR1 and VEGFR2, Signaling events mediated by focal adhesion kinase, Signaling events regulated by Ret tyrosine kinase, Stabilization and expansion of the E-cadherin adherens junction, T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, T-cell receptor (TCR) signaling pathway, TCR, TCR signaling in naïve CD4+ T cells, VEGFA-VEGFR2 Signaling Pathway, VEGFR1 specific signals, y branching of actin filaments
UniProt: P16333
Entrez ID: 4690
|
Does Knockout of DNTTIP2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
DNTTIP2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DNTTIP2 (deoxynucleotidyltransferase terminal interacting protein 2)
Type: protein-coding
Summary: This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: RNA processing, ribosomal small subunit biogenesis; MF: RNA binding, protein binding; CC: chromosome, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways:
UniProt: Q5QJE6
Entrez ID: 30836
|
Does Knockout of SCMH1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
SCMH1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SCMH1 (Scm polycomb group protein homolog 1)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within anterior/posterior pattern specification; chromatin remodeling; and spermatogenesis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: heterochromatin formation, negative regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: chromatin binding, histone binding, protein binding; CC: nucleoplasm, nucleus
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, Metabolism of proteins, Oxidative Stress Induced Senescence, PIP3 activates AKT signaling, PTEN Regulation, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, Regulation of PTEN gene transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA methylation proteins, SUMOylation of RNA binding proteins, SUMOylation of chromatin organization proteins, SUMOylation of transcription cofactors, Signal Transduction, Transcriptional regulation by RUNX1
UniProt: Q96GD3
Entrez ID: 22955
|
Does Knockout of PPP2R3C in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
PPP2R3C
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PPP2R3C (protein phosphatase 2 regulatory subunit B''gamma)
Type: protein-coding
Summary: This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: B cell homeostasis, T cell homeostasis, cortical cytoskeleton organization, microtubule cytoskeleton organization, positive regulation of B cell differentiation, regulation of B cell activation, regulation of antimicrobial humoral response, regulation of dephosphorylation, regulation of mitochondrial depolarization, spleen development; MF: metal ion binding, protein binding; CC: Golgi apparatus, actin cytoskeleton, centrosome, cilium, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: AMPK signaling pathway - Homo sapiens (human), Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Dopaminergic synapse - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Human papillomavirus infection - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Sphingolipid signaling pathway - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q969Q6
Entrez ID: 55012
|
Does Knockout of PKD2L1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
PKD2L1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel)
Type: protein-coding
Summary: This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, cellular response to acidic pH, cellular response to pH, detection of chemical stimulus involved in sensory perception of sour taste, detection of chemical stimulus involved in sensory perception of taste, detection of mechanical stimulus, inorganic cation transmembrane transport, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, protein homotetramerization, protein tetramerization, response to water, sensory perception of sour taste, smoothened signaling pathway, sodium ion transmembrane transport; MF: actinin binding, alpha-actinin binding, calcium channel activity, calcium ion binding, calcium-activated cation channel activity, calcium-activated potassium channel activity, cytoskeletal protein binding, identical protein binding, metal ion binding, metal ion transmembrane transporter activity, monoatomic cation channel activity, monoatomic cation transmembrane transporter activity, muscle alpha-actinin binding, osmolarity-sensing monoatomic cation channel activity, pH-gated monoatomic ion channel activity, protein binding, sodium channel activity, sour taste receptor activity, transmembrane transporter binding; CC: actin cytoskeleton, calcium channel complex, cation channel complex, cell projection, cell surface, ciliary membrane, cilium, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, membrane, non-motile cilium, plasma membrane, receptor complex
Pathways: Taste transduction - Homo sapiens (human)
UniProt: Q9P0L9
Entrez ID: 9033
|
Does Knockout of CLPB in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
CLPB
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CLPB (ClpB family mitochondrial disaggregase)
Type: protein-coding
Summary: This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: RIG-I signaling pathway, antiviral innate immune response, cellular response to heat, granulocyte differentiation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein disaggregase activity, hydrolase activity, nucleotide binding, protein binding; CC: cytoplasm, mitochondrial intermembrane space, mitochondrion
Pathways: Longevity regulating pathway - multiple species - Homo sapiens (human)
UniProt: Q9H078
Entrez ID: 81570
|
Does Knockout of ISG20L2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
ISG20L2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ISG20L2 (interferon stimulated exonuclease gene 20 like 2)
Type: protein-coding
Summary: This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: DNA metabolic process, RNA processing, ribosome biogenesis; MF: 3'-5'-RNA exonuclease activity, RNA binding, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, protein binding; CC: nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9H9L3
Entrez ID: 81875
|
Does Knockout of RIC1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
RIC1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: RIC1 (RIC1 partner of RAB6A GEF complex)
Type: protein-coding
Summary: Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including positive regulation of GTPase activity; regulation of extracellular matrix constituent secretion; and retrograde transport, endosome to Golgi. Located in cytosol and membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cranial skeletal system development, intracellular protein transport, negative regulation of protein catabolic process, positive regulation of GTPase activity, regulation of extracellular matrix constituent secretion, retrograde transport, endosome to Golgi; MF: guanyl-nucleotide exchange factor activity, protein binding, small GTPase binding; CC: Golgi membrane, Ric1-Rgp1 guanyl-nucleotide exchange factor complex, cytoplasm, cytosol, membrane, protein-containing complex, trans-Golgi network membrane
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q4ADV7
Entrez ID: 57589
|
Does Knockout of PIM2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
PIM2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: PIM2 (Pim-2 proto-oncogene, serine/threonine kinase)
Type: protein-coding
Summary: This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, apoptotic mitochondrial changes, apoptotic process, macroautophagy, negative regulation of apoptotic process, negative regulation of cell population proliferation, positive regulation of DNA-templated transcription, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of macroautophagy, protein phosphorylation, protein stabilization, regulation of mitotic cell cycle, response to virus; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways: Acute myeloid leukemia - Homo sapiens (human), Imatinib and Chronic Myeloid Leukemia, Pathways in cancer - Homo sapiens (human), Translation inhibitors in chronically activated PDGFRA cells
UniProt: Q9P1W9
Entrez ID: 11040
|
Does Knockout of LSM4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
LSM4
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: LSM4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: P-body assembly, RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, spliceosomal snRNP assembly; MF: PH domain binding, RNA binding, U6 snRNA binding, protein binding; CC: Lsm2-8 complex, P-body, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytosol, membrane, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Ciliary landscape, Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Homo sapiens (human), Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q9Y4Z0
Entrez ID: 25804
|
Does Knockout of FKBP11 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
FKBP11
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: FKBP11 (FKBP prolyl isomerase 11)
Type: protein-coding
Summary: FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008].
Gene Ontology: MF: isomerase activity, peptidyl-prolyl cis-trans isomerase activity; CC: endoplasmic reticulum, membrane
Pathways:
UniProt: Q9NYL4
Entrez ID: 51303
|
Does Knockout of HERC6 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
HERC6
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: HERC6 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 6)
Type: protein-coding
Summary: HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: hematopoietic progenitor cell differentiation, protein ubiquitination, response to bacterium, ubiquitin-dependent protein catabolic process; MF: transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q8IVU3
Entrez ID: 55008
|
Does Knockout of LGALS1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
LGALS1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: LGALS1 (galectin 1)
Type: protein-coding
Summary: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell costimulation, apoptotic process, cell-cell adhesion, myoblast differentiation, negative regulation of T-helper 17 cell lineage commitment, plasma cell differentiation, positive regulation of apoptotic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of dendritic cell differentiation, positive regulation of inflammatory response, positive regulation of viral entry into host cell, regulation of apoptotic process, signal transduction; MF: RNA binding, carbohydrate binding, lactose binding, laminin binding, protein binding, receptor ligand activity; CC: cytoplasm, cytosol, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix, extracellular region, extracellular space, galectin complex, plasma membrane
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Regulation of Ras family activation, Validated targets of C-MYC transcriptional repression
UniProt: P09382
Entrez ID: 3956
|
Does Knockout of RFFL in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
RFFL
|
cell proliferation
|
T-lymphoma cell line
|
Gene: RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase)
Type: protein-coding
Summary: Enables enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in cellular protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; and negative regulation of signal transduction. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, intracellular protein transport, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of signal transduction by p53 class mediator, negative regulation of tumor necrosis factor-mediated signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein ubiquitination, regulation of TOR signaling, regulation of fibroblast migration, regulation of signal transduction by p53 class mediator, ubiquitin-dependent protein catabolic process; MF: metal ion binding, p53 binding, protease binding, protein binding, protein kinase binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, zinc ion binding; CC: Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endosome, endosome membrane, lysosome, membrane, nucleoplasm, plasma membrane, recycling endosome membrane
Pathways: TNF receptor signaling pathway , TNF-alpha signaling pathway, TNFalpha
UniProt: Q8WZ73
Entrez ID: 117584
|
Does Knockout of AREL1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
AREL1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Enables ubiquitin-protein transferase activity. Involved in negative regulation of apoptotic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, protein K11-linked ubiquitination, protein K33-linked ubiquitination, protein ubiquitination, regulation of inflammatory response, ubiquitin-dependent protein catabolic process; MF: protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: cytoplasm, cytosol
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: O15033
Entrez ID: 9870
|
Does Knockout of MEPCE in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
MEPCE
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MEPCE (methylphosphate capping enzyme)
Type: protein-coding
Summary: Enables 7SK snRNA binding activity and RNA 5'-methyltransferase activity. Involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Located in nucleus. Part of 7SK snRNP. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA methylation, methylation, negative regulation of transcription by RNA polymerase II, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of protein localization to Cajal body, positive regulation of snRNA transcription by RNA polymerase II, snRNA metabolic process, snRNA modification; MF: 7SK snRNA binding, O-methyltransferase activity, RNA 5'-gamma-phosphate methyltransferase activity, RNA binding, RNA methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, protein binding, snRNA binding, transferase activity; CC: 7SK snRNP, nucleus, ribonucleoprotein complex
Pathways: IL-18 signaling pathway
UniProt: Q7L2J0
Entrez ID: 56257
|
Does Knockout of SPINT3 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 1
| 1,480
|
Knockout
|
SPINT3
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: SPINT3 (serine peptidase inhibitor, Kunitz type 3)
Type: protein-coding
Summary: Predicted to enable receptor antagonist activity and transforming growth factor beta binding activity. Predicted to be involved in negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity
Pathways:
UniProt: P49223
Entrez ID: 10816
|
Does Knockout of NDUFAB1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
NDUFAB1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1)
Type: protein-coding
Summary: Predicted to enable acyl binding activity; acyl carrier activity; and fatty acid binding activity. Involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Located in mitochondrion and nucleoplasm. Part of mitochondrial respiratory chain complex I. Colocalizes with mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: [2Fe-2S] cluster assembly, aerobic respiration, fatty acid biosynthetic process, fatty acid metabolic process, iron-sulfur cluster assembly, lipid metabolic process, mitochondrial electron transport, NADH to ubiquinone, protein lipoylation, proton motive force-driven mitochondrial ATP synthesis; MF: acyl binding, acyl carrier activity, calcium ion binding, fatty acid binding, mitochondrial large ribosomal subunit binding, protein binding, structural molecule activity; CC: iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleoplasm, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Fatty acid metabolism, Huntington disease - Homo sapiens (human), Metabolism, Metabolism of lipids, Metabolism of proteins, Mitochondrial Fatty Acid Beta-Oxidation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Protein lipoylation, Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human), Translation
UniProt: O14561
Entrez ID: 4706
|
Does Knockout of RBM48 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
RBM48
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: RBM48 (RNA binding motif protein 48)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing; MF: RNA binding, nucleic acid binding, protein binding; CC: nucleoplasm, spliceosomal complex
Pathways:
UniProt: Q5RL73
Entrez ID: 84060
|
Does Knockout of BAP1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
BAP1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: BAP1 (BRCA1 associated deubiquitinase 1)
Type: protein-coding
Summary: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013].
Gene Ontology: BP: cell differentiation, cell population proliferation, chromatin organization, common myeloid progenitor cell proliferation, erythrocyte differentiation, erythrocyte maturation, gene expression, granulocyte differentiation, hematopoietic stem cell homeostasis, heterochromatin formation, in utero embryonic development, leukocyte proliferation, macrophage homeostasis, mitotic cell cycle, monoubiquitinated protein deubiquitination, myeloid cell apoptotic process, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, neuron cellular homeostasis, neutrophil differentiation, nucleate erythrocyte differentiation, platelet morphogenesis, positive regulation of protein targeting to mitochondrion, protein K48-linked deubiquitination, protein deubiquitination, protein modification process, proteolysis, regulation of cell cycle, regulation of cell growth, regulation of cytokine production involved in inflammatory response, regulation of gene expression, regulation of inflammatory response, thrombocyte differentiation, tissue homeostasis, ubiquitin-dependent protein catabolic process; MF: chromatin DNA binding, chromatin binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2A deubiquitinase activity, hydrolase activity, peptidase activity, protein binding; CC: PR-DUB complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, Metabolism of proteins, Pathways in clear cell renal cell carcinoma, Post-translational protein modification, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, UCH proteinases
UniProt: Q92560
Entrez ID: 8314
|
Does Knockout of GPR142 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
GPR142
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: GPR142 (G protein-coupled receptor 142)
Type: protein-coding
Summary: GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; CC: cell junction, cytosol, membrane, plasma membrane
Pathways:
UniProt: Q7Z601
Entrez ID: 350383
|
Does Knockout of CLPB in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
CLPB
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CLPB (ClpB family mitochondrial disaggregase)
Type: protein-coding
Summary: This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: RIG-I signaling pathway, antiviral innate immune response, cellular response to heat, granulocyte differentiation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein disaggregase activity, hydrolase activity, nucleotide binding, protein binding; CC: cytoplasm, mitochondrial intermembrane space, mitochondrion
Pathways: Longevity regulating pathway - multiple species - Homo sapiens (human)
UniProt: Q9H078
Entrez ID: 81570
|
Does Activation of DRD3 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
DRD3
|
protein/peptide accumulation
|
T cell
|
Gene: DRD3 (dopamine receptor D3)
Type: protein-coding
Summary: This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor internalization, G protein-coupled receptor signaling pathway, acid secretion, adenylate cyclase-activating dopamine receptor signaling pathway, adenylate cyclase-inhibiting dopamine receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, arachidonate secretion, behavioral response to cocaine, circadian regulation of gene expression, dopamine metabolic process, intracellular calcium ion homeostasis, learning, learning or memory, locomotory behavior, musculoskeletal movement, spinal reflex action, negative regulation of G protein-coupled receptor signaling pathway, negative regulation of blood pressure, negative regulation of cytosolic calcium ion concentration, negative regulation of oligodendrocyte differentiation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of protein secretion, negative regulation of synaptic transmission, glutamatergic, phospholipase C-activating dopamine receptor signaling pathway, positive regulation of cytokinesis, positive regulation of dopamine receptor signaling pathway, positive regulation of mitotic nuclear division, prepulse inhibition, regulation of amine transport, regulation of dopamine secretion, regulation of dopamine uptake involved in synaptic transmission, regulation of potassium ion transport, regulation of secretion by cell, response to cocaine, response to ethanol, response to histamine, response to morphine, response to xenobiotic stimulus, signal transduction, social behavior, synaptic transmission, dopaminergic, visual learning; MF: G protein-coupled receptor activity, dopamine neurotransmitter receptor activity, dopamine neurotransmitter receptor activity, coupled via Gi/Go, protein binding; CC: membrane, plasma membrane, synapse
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), Dopamine receptors, Dopaminergic synapse - Homo sapiens (human), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, GPCRs, Other, Monoamine GPCRs, Neuroactive ligand-receptor interaction - Homo sapiens (human), Nicotine Activity on Dopaminergic Neurons, Signal Transduction, Signaling by GPCR
UniProt: P35462
Entrez ID: 1814
|
Does Knockout of DDX21 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
DDX21
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: DDX21 (DExD-box helicase 21)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: R-loop processing, chromatin remodeling, defense response to virus, immune system process, innate immune response, negative regulation of transcription by RNA polymerase I, osteoblast differentiation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of macromolecule biosynthetic process, positive regulation of myeloid dendritic cell cytokine production, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, rRNA processing, regulation of gene expression, response to exogenous dsRNA, response to virus, transcription by RNA polymerase II; MF: 7SK snRNA binding, ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA polymerase inhibitor activity, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, mRNA binding, miRNA binding, nucleic acid binding, nucleotide binding, protein binding, rRNA binding, snoRNA binding; CC: B-WICH complex, chromosome, cytoplasm, cytosol, membrane, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Positive epigenetic regulation of rRNA expression, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NR30
Entrez ID: 9188
|
Does Knockout of NOL12 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
NOL12
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: NOL12 (nucleolar protein 12)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, identical protein binding, protein binding, rRNA binding, single-stranded DNA binding; CC: cytoplasm, nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9UGY1
Entrez ID: 79159
|
Does Knockout of FLOT1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
FLOT1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: FLOT1 (flotillin 1)
Type: protein-coding
Summary: This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: adherens junction organization, axonogenesis, caveola assembly, extracellular matrix disassembly, intracellular signal transduction, plasma membrane raft assembly, plasma membrane raft organization, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell junction assembly, positive regulation of cell-cell adhesion, positive regulation of cell-cell adhesion mediated by cadherin, positive regulation of endocytosis, positive regulation of myoblast fusion, positive regulation of skeletal muscle tissue development, positive regulation of synaptic transmission, dopaminergic, protein localization to plasma membrane, regulation of Rho protein signal transduction, regulation of neurotransmitter uptake, regulation of receptor internalization; MF: ionotropic glutamate receptor binding, protease binding, protein binding; CC: COP9 signalosome, GABA-ergic synapse, adherens junction, apical plasma membrane, basolateral plasma membrane, caveola, cell-cell contact zone, cell-cell junction, centriolar satellite, cortical actin cytoskeleton, cytoplasmic vesicle, dopaminergic synapse, early endosome, endosome, external side of plasma membrane, extracellular exosome, flotillin complex, focal adhesion, glutamatergic synapse, lamellipodium, lysosomal membrane, melanosome, membrane, membrane raft, microtubule organizing center, plasma membrane, plasma membrane raft, presynapse, presynaptic active zone, sarcolemma, synapse, uropod
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, EGFR1, Insulin Signaling, Insulin signaling pathway - Homo sapiens (human)
UniProt: O75955
Entrez ID: 10211
|
Does Knockout of STK11 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
STK11
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: STK11 (serine/threonine kinase 11)
Type: protein-coding
Summary: The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by RefSeq, May 2022].
Gene Ontology: BP: DNA damage response, G1 to G0 transition, Golgi localization, T cell receptor signaling pathway, activation of protein kinase activity, anoikis, apoptotic process, autophagy, axonogenesis, cell differentiation, cellular response to UV-B, dendrite extension, epithelial cell proliferation involved in prostate gland development, establishment of cell polarity, glucose homeostasis, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of TORC1 signaling, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of cold-induced thermogenesis, negative regulation of epithelial cell proliferation involved in prostate gland development, peptidyl-threonine phosphorylation, positive regulation of autophagy, positive regulation of axonogenesis, positive regulation of protein localization to nucleus, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of vesicle transport along microtubule, positive thymic T cell selection, protein autophosphorylation, protein dephosphorylation, protein localization to nucleus, protein phosphorylation, regulation of Wnt signaling pathway, regulation of cell cycle, regulation of cell growth, regulation of dendrite morphogenesis, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of signal transduction by p53 class mediator, response to ionizing radiation, signal transduction, spermatogenesis, tissue homeostasis, vasculature development; MF: ATP binding, LRR domain binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, p53 binding, protein binding, protein kinase activator activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, cilium, cytoplasm, cytosol, extracellular exosome, intracellular protein-containing complex, membrane, mitochondrion, nucleoplasm, nucleus, serine/threonine protein kinase complex
Pathways: AMP-activated protein kinase (AMPK) signaling, AMPK inhibits chREBP transcriptional activation activity, AMPK signaling pathway - Homo sapiens (human), ATM Signaling Network in Development and Disease, Adipocytokine signaling pathway - Homo sapiens (human), Autophagy - animal - Homo sapiens (human), EGFR1, Energy dependent regulation of mTOR by LKB1-AMPK, FOXO-mediated transcription, FOXO-mediated transcription of cell death genes, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, FoxO signaling pathway - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, Head and Neck Squamous Cell Carcinoma, Integrated breast cancer pathway, Integration of energy metabolism, LKB1 signaling events, Longevity regulating pathway - Homo sapiens (human), MTOR signalling, Metabolism, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, TGF_beta_Receptor, Tight junction - Homo sapiens (human), Transcriptional Regulation by TP53, mTOR signaling pathway - Homo sapiens (human), mir-124 predicted interactions with cell cycle and differentiation
UniProt: Q15831
Entrez ID: 6794
|
Does Knockout of KCTD20 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
KCTD20
|
response to virus
|
Hepatoma Cell Line
|
Gene: KCTD20 (potassium channel tetramerization domain containing 20)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of phosphorylation. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of phosphorylation; CC: cytoplasm
Pathways:
UniProt: Q7Z5Y7
Entrez ID: 222658
|
Does Knockout of HAUS4 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
HAUS4
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: HAUS4 (HAUS augmin like complex subunit 4)
Type: protein-coding
Summary: This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: cell division, centrosome cycle, regulation of microtubule nucleation, spindle assembly; MF: microtubule minus-end binding, protein binding; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule, mitotic spindle microtubule, spindle
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9H6D7
Entrez ID: 54930
|
Does Knockout of HSPE1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
HSPE1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: HSPE1 (heat shock protein family E (Hsp10) member 1)
Type: protein-coding
Summary: This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011].
Gene Ontology: BP: intrinsic apoptotic signaling pathway, osteoblast differentiation, protein folding, response to unfolded protein; MF: ATP binding, RNA binding, metal ion binding, protein binding, protein folding chaperone, protein-folding chaperone binding, unfolded protein binding; CC: extracellular exosome, membrane, mitochondrial matrix, mitochondrion
Pathways: Cellular responses to stimuli, Cellular responses to stress, EGFR1, Mitochondrial unfolded protein response (UPRmt), RHO GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P61604
Entrez ID: 3336
|
Does Knockout of TYROBP in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
TYROBP
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TYROBP (transmembrane immune signaling adaptor TYROBP)
Type: protein-coding
Summary: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, actin cytoskeleton organization, amyloid-beta clearance, apoptotic cell clearance, cell surface receptor signaling pathway, cellular defense response, cellular response to amyloid-beta, defense response, forebrain development, immune effector process, immune response, immune system process, integrin-mediated signaling pathway, intracellular signal transduction, macrophage activation involved in immune response, microglial cell activation involved in immune response, myeloid leukocyte activation, natural killer cell mediated immunity, negative regulation of B cell proliferation, negative regulation of cytokine production, negative regulation of interleukin-10 production, negative regulation of long-term synaptic potentiation, negative regulation of transforming growth factor beta1 production, negative regulation of type I interferon production, neutrophil activation involved in immune response, osteoclast differentiation, positive regulation of gene expression, positive regulation of immune system process, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, positive regulation of macrophage fusion, positive regulation of microglial cell mediated cytotoxicity, positive regulation of natural killer cell activation, positive regulation of osteoclast development, positive regulation of protein localization to cell surface, positive regulation of receptor localization to synapse, positive regulation of superoxide anion generation, positive regulation of tumor necrosis factor production, positive regulation of type I interferon production, protein stabilization, regulation of biological quality, regulation of osteoclast development, response to axon injury, semaphorin-plexin signaling pathway, signal transduction, stimulatory C-type lectin receptor signaling pathway, stimulatory killer cell immunoglobulin-like receptor signaling pathway; MF: identical protein binding, metal ion binding, molecular adaptor activity, protein binding, protein homodimerization activity, protein-macromolecule adaptor activity, signaling receptor binding; CC: cell surface, membrane, plasma membrane, secretory granule membrane
Pathways: Adaptive Immune System, Axon guidance, Cell-Cell communication, DAP12 interactions, DAP12 signaling, Developmental Biology, Fibrin Complement Receptor 3 Signaling Pathway, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Microglia Pathogen Phagocytosis Pathway, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Nervous system development, Neutrophil degranulation, Osteoclast differentiation - Homo sapiens (human), Other semaphorin interactions, RANKL, Semaphorin interactions, Signal regulatory protein family interactions, TYROBP causal network in microglia
UniProt: O43914
Entrez ID: 7305
|
Does Knockout of OR2T33 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
OR2T33
|
cell proliferation
|
Melanoma Cell Line
|
Gene: OR2T33 (olfactory receptor family 2 subfamily T member 33)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NG76
Entrez ID: 391195
|
Does Knockout of TCOF1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
TCOF1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: TCOF1 (treacle ribosome biogenesis factor 1)
Type: protein-coding
Summary: This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
Gene Ontology: BP: neural crest cell development, neural crest formation, nucleolar large rRNA transcription by RNA polymerase I, regulation of translation, skeletal system development; MF: RNA binding, protein binding, protein heterodimerization activity, protein-macromolecule adaptor activity, scaffold protein binding; CC: cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q13428
Entrez ID: 6949
|
Does Knockout of SARS2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
SARS2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SARS2 (seryl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: mitochondrial seryl-tRNA aminoacylation, seryl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, RNA binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, protein binding, serine-tRNA ligase activity, tRNA binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Metabolism of proteins, Mitochondrial tRNA aminoacylation, Translation, selenocysteine biosynthesis, tRNA Aminoacylation, tRNA charging
UniProt: Q9NP81
Entrez ID: 54938
|
Does Knockout of GFER in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
GFER
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GFER (growth factor, augmenter of liver regeneration)
Type: protein-coding
Summary: The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: liver development, mitochondrial disulfide relay system, signal transduction; MF: flavin adenine dinucleotide binding, flavin-dependent sulfhydryl oxidase activity, growth factor activity, oxidoreductase activity, protein binding, protein-disulfide reductase activity, thiol oxidase activity; CC: cytoplasm, cytosol, extracellular region, mitochondrial intermembrane space, mitochondrion
Pathways: Mitochondrial protein import, Protein localization
UniProt: P55789
Entrez ID: 2671
|
Does Knockout of CHMP3 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
CHMP3
|
cell proliferation
|
Cancer Cell Line
|
Gene: CHMP3 (charged multivesicular body protein 3)
Type: protein-coding
Summary: This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: apoptotic process, autophagosome maturation, autophagy, cell division, endosome to lysosome transport, endosome transport via multivesicular body sorting pathway, late endosome to lysosome transport, late endosome to vacuole transport, macroautophagy, membrane fission, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, positive regulation of cytokinesis, protein polymerization, protein transport, regulation of centrosome duplication, regulation of early endosome to late endosome transport, regulation of endosome size, regulation of exosomal secretion, regulation of mitotic spindle assembly, suppression of viral release by host, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex, viral release from host cell; MF: identical protein binding, molecular function inhibitor activity, phosphatidylcholine binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, ubiquitin-specific protease binding; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, cytoplasm, cytoplasmic vesicle, cytosol, early endosome, endosome, extracellular exosome, kinetochore, kinetochore microtubule, late endosome, late endosome membrane, lysosomal membrane, membrane, midbody, multivesicular body, multivesicular body membrane, nuclear pore, plasma membrane
Pathways: Endocytosis - Homo sapiens (human), Internalization of ErbB1, Necroptosis - Homo sapiens (human)
UniProt: Q9Y3E7
Entrez ID: 51652
|
Does Knockout of POLR3D in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
POLR3D
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: POLR3D (RNA polymerase III subunit D)
Type: protein-coding
Summary: This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: defense response to virus, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta production, tRNA transcription by RNA polymerase III, transcription by RNA polymerase III; MF: DNA binding, chromatin binding; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, cytosol, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , Eukaryotic Transcription Initiation, Gene expression (Transcription), Immune System, Innate Immune System, Pyrimidine metabolism, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human), Validated targets of C-MYC transcriptional activation
UniProt: P05423
Entrez ID: 661
|
Does Knockout of ZNF701 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
ZNF701
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: ZNF701 (zinc finger protein 701)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9NV72
Entrez ID: 55762
|
Does Knockout of SLC18A1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
SLC18A1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SLC18A1 (solute carrier family 18 member A1)
Type: protein-coding
Summary: The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: aminergic neurotransmitter loading into synaptic vesicle, dopamine transport, dopamine uptake, establishment of localization in cell, monoamine transport, neurotransmitter transport, norepinephrine uptake, proton transmembrane transport, serotonin transport, serotonin uptake, transmembrane transport, xenobiotic transport; MF: monoamine transmembrane transporter activity, monoamine:proton antiporter activity, protein binding, serotonin:sodium:chloride symporter activity, transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: clathrin-sculpted monoamine transport vesicle membrane, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, presynapse, secretory granule membrane, synapse, synaptic vesicle membrane, terminal bouton, transport vesicle membrane
Pathways: Alcoholism - Homo sapiens (human), Amphetamine addiction - Homo sapiens (human), Cocaine addiction - Homo sapiens (human), Dopaminergic synapse - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Synaptic Vesicle Pathway, Synaptic vesicle cycle - Homo sapiens (human)
UniProt: P54219
Entrez ID: 6570
|
Does Knockout of RPS15 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
RPS15
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: RPS15 (ribosomal protein S15)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cytoplasmic translation, liver regeneration, osteoblast differentiation, positive regulation of signal transduction by p53 class mediator, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus, translation; MF: DNA binding, MDM2/MDM4 family protein binding, RNA binding, protein binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, focal adhesion, membrane, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62841
Entrez ID: 6209
|
Does Knockout of UBXN1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
UBXN1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: UBXN1 (UBX domain protein 1)
Type: protein-coding
Summary: Enables several functions, including enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome regulatory particle binding activity. Involved in negative regulation of cellular protein metabolic process. Located in cytosol; endoplasmic reticulum; and nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of ERAD pathway, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein K48-linked deubiquitination, negative regulation of protein ubiquitination, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATPase binding, K48-linked polyubiquitin modification-dependent protein binding, K6-linked polyubiquitin modification-dependent protein binding, polyubiquitin modification-dependent protein binding, proteasome regulatory particle binding, protein binding, ubiquitin binding, ubiquitin protein ligase binding; CC: VCP-NPL4-UFD1 AAA ATPase complex, cytoplasm, cytosol, endoplasmic reticulum, nucleoplasm, nucleus
Pathways: Protein processing in endoplasmic reticulum - Homo sapiens (human)
UniProt: Q04323
Entrez ID: 51035
|
Does Knockout of PNN in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
PNN
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PNN (pinin, desmosome associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in cell adhesion and mRNA splicing, via spliceosome. Predicted to act upstream of or within cell-cell adhesion. Located in nuclear speck. Part of catalytic step 2 spliceosome. Colocalizes with exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, cell adhesion, mRNA processing, mRNA splicing, via spliceosome; MF: DNA binding, RNA binding, protein binding, structural molecule activity; CC: anchoring junction, catalytic step 2 spliceosome, cell-cell junction, desmosome, exon-exon junction complex, intermediate filament, membrane, nuclear speck, nucleoplasm, nucleus, plasma membrane, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9H307
Entrez ID: 5411
|
Does Knockout of LUM in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
LUM
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: LUM (lumican)
Type: protein-coding
Summary: This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cartilage development, collagen fibril organization, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta1 production, response to Aroclor 1254, response to growth factor, visual perception; MF: collagen binding, extracellular matrix structural constituent, extracellular matrix structural constituent conferring compression resistance, protein binding; CC: Golgi lumen, extracellular exosome, extracellular matrix, extracellular region, extracellular space, fibrillar collagen trimer, lysosomal lumen
Pathways: Defective B4GALT1 causes B4GALT1-CDG (CDG-2d), Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, Disease, Diseases associated with glycosaminoglycan metabolism, Diseases of glycosylation, Diseases of metabolism, ECM proteoglycans, Extracellular matrix organization, Glycosaminoglycan metabolism, Integrin cell surface interactions, Keratan sulfate biosynthesis, Keratan sulfate degradation, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Proteoglycans in cancer - Homo sapiens (human)
UniProt: P51884
Entrez ID: 4060
|
Does Knockout of OGT in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
OGT
|
response to virus
|
Lung Cancer Cell Line
|
Gene: OGT (O-linked N-acetylglucosamine (GlcNAc) transferase)
Type: protein-coding
Summary: This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: TORC1 signaling, apoptotic process, cellular response to glucose stimulus, cellular response to nutrient levels, chromatin organization, circadian regulation of gene expression, cytoplasmic translation, hemopoiesis, membraneless organelle assembly, mitophagy, negative regulation of cell migration, negative regulation of non-canonical inflammasome complex assembly, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein ubiquitination, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of translation, negative regulation of translational initiation, non-canonical inflammasome complex assembly, positive regulation of DNA-templated transcription, positive regulation of TORC1 signaling, positive regulation of cold-induced thermogenesis, positive regulation of lipid biosynthetic process, positive regulation of proteolysis, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription from RNA polymerase II promoter by glucose, positive regulation of translation, positive regulation of translational initiation, protein O-linked glycosylation, protein glycosylation, protein localization to lysosome, protein maturation, protein processing, pyroptotic inflammatory response, regulation of Rac protein signal transduction, regulation of gluconeogenesis, regulation of glycolytic process, regulation of insulin receptor signaling pathway, regulation of necroptotic process, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, regulation of synapse assembly, regulation of transcription by RNA polymerase II, response to insulin, response to nutrient, rhythmic process, signal transduction; MF: acetylglucosaminyltransferase activity, chromatin DNA binding, glycosyltransferase activity, lipid binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein O-acetylglucosaminyltransferase activity, protein binding, transferase activity; CC: NSL complex, Sin3-type complex, cell projection, cytoplasm, cytosol, glutamatergic synapse, histone acetyltransferase complex, membrane, mitochondrial membrane, mitochondrion, nucleoplasm, nucleus, plasma membrane, protein N-acetylglucosaminyltransferase complex, protein-containing complex, synapse
Pathways: Ectoderm Differentiation, Insulin resistance - Homo sapiens (human), Other types of O-glycan biosynthesis - Homo sapiens (human), protein <i>O</i>-[<i>N</i>-acetyl]-glucosylation
UniProt: O15294
Entrez ID: 8473
|
Does Knockout of NCKAP1L in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
NCKAP1L
|
response to virus
|
Huh-7 Cell
|
Gene: NCKAP1L (NCK associated protein 1 like)
Type: protein-coding
Summary: This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010].
Gene Ontology: BP: B cell homeostasis, B cell receptor signaling pathway, T cell homeostasis, actin polymerization-dependent cell motility, cell migration, cell morphogenesis, cell projection assembly, chemotaxis, cortical actin cytoskeleton organization, erythrocyte development, erythrocyte homeostasis, intracellular signal transduction, maintenance of cell polarity, myeloid cell homeostasis, negative regulation of apoptotic process, negative regulation of cytotoxic T cell degranulation, negative regulation of interleukin-17 production, negative regulation of interleukin-6 production, neuron projection morphogenesis, positive regulation of B cell differentiation, positive regulation of B cell proliferation, positive regulation of CD4-positive, alpha-beta T cell differentiation, positive regulation of CD8-positive, alpha-beta T cell differentiation, positive regulation of T cell proliferation, positive regulation of TORC2 signaling, positive regulation of actin filament polymerization, positive regulation of cell adhesion mediated by integrin, positive regulation of erythrocyte differentiation, positive regulation of gamma-delta T cell differentiation, positive regulation of leukocyte migration, positive regulation of lymphocyte differentiation, positive regulation of neutrophil chemotaxis, positive regulation of neutrophil migration, positive regulation of phagocytosis, engulfment, protein-containing complex assembly, response to xenobiotic stimulus; MF: GTPase activator activity, TORC2 complex binding, protein binding, protein kinase activator activity, protein-containing complex binding; CC: SCAR complex, cytoplasm, cytosol, extracellular exosome, ficolin-1-rich granule membrane, membrane, plasma membrane, secretory granule membrane
Pathways: Disease, FCGR3A-mediated phagocytosis, Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania phagocytosis, Microglia Pathogen Phagocytosis Pathway, Neutrophil degranulation, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, TYROBP causal network in microglia, VEGFA-VEGFR2 Pathway
UniProt: P55160
Entrez ID: 3071
|
Does Knockout of NOP53 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
NOP53
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: NOP53 (NOP53 ribosome biogenesis factor)
Type: protein-coding
Summary: Enables 5S rRNA binding activity; identical protein binding activity; and p53 binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; regulation of cellular protein metabolic process; and regulation of intracellular signal transduction. Located in cytosol; fibrillar center; and nucleoplasm. Colocalizes with rDNA heterochromatin. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to hypoxia, mitotic G2 DNA damage checkpoint signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein-containing complex assembly, negative regulation of signal transduction by p53 class mediator, negative regulation of transcription by RNA polymerase II, negative regulation of transcription of nucleolar large rRNA by RNA polymerase I, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K63-linked deubiquitination, protein localization to nucleolus, protein localization to nucleoplasm, protein stabilization, rRNA processing, regulation of RIG-I signaling pathway, regulation of aerobic respiration, regulation of apoptotic process, regulation of cell cycle, regulation of protein phosphorylation, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosome biogenesis; MF: 5S rRNA binding, RNA binding, identical protein binding, p53 binding, protein binding; CC: cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus, rDNA heterochromatin
Pathways:
UniProt: Q9NZM5
Entrez ID: 29997
|
Does Knockout of TRAPPC1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
TRAPPC1
|
cell proliferation
|
Cancer Cell Line
|
Gene: TRAPPC1 (trafficking protein particle complex subunit 1)
Type: protein-coding
Summary: This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, azurophil granule lumen, cytoplasm, cytosol, endoplasmic reticulum, extracellular region
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9Y5R8
Entrez ID: 58485
|
Does Knockout of SRSF6 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
SRSF6
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: SRSF6 (serine and arginine rich splicing factor 6)
Type: protein-coding
Summary: The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splice site recognition, negative regulation of gene expression, negative regulation of keratinocyte differentiation, negative regulation of mRNA splicing, via spliceosome, negative regulation of type B pancreatic cell apoptotic process, positive regulation of epithelial cell proliferation involved in lung morphogenesis, regulation of alternative mRNA splicing, via spliceosome, regulation of keratinocyte proliferation, regulation of wound healing, response to insulin; MF: RNA binding, mRNA binding, nucleic acid binding, pre-mRNA binding, protein binding; CC: nuclear speck, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q13247
Entrez ID: 6431
|
Does Knockout of MBNL1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
MBNL1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: MBNL1 (muscleblind like splicing regulator 1)
Type: protein-coding
Summary: This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: RNA splicing, embryonic limb morphogenesis, in utero embryonic development, mRNA processing, myoblast differentiation, nervous system development, regulation of RNA splicing; MF: RNA binding, double-stranded RNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, nucleoplasm, nucleus
Pathways: Adipogenesis
UniProt: Q9NR56
Entrez ID: 4154
|
Does Knockout of LEAP2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
LEAP2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: LEAP2 (liver enriched antimicrobial peptide 2)
Type: protein-coding
Summary: This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, defense response to bacterium, defense response to fungus; CC: extracellular region
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: Q969E1
Entrez ID: 116842
|
Does Knockout of BRD1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
BRD1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: BRD1 (bromodomain containing 1)
Type: protein-coding
Summary: This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: chromatin organization, chromatin remodeling, erythrocyte maturation, positive regulation of erythrocyte differentiation, regulation of DNA-templated transcription, regulation of developmental process, regulation of hemopoiesis, regulation of transcription by RNA polymerase II, response to electrical stimulus, response to immobilization stress; MF: histone H3K14 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone reader activity, metal ion binding, protein binding, unmodified histone reader activity, zinc ion binding; CC: MOZ/MORF histone acetyltransferase complex, chromosome, dendrite, histone H3-K14 acetyltransferase complex, nuclear speck, nucleus, perikaryon
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, Pathways affected in adenoid cystic carcinoma, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Transcriptional Regulation by TP53
UniProt: O95696
Entrez ID: 23774
|
Does Knockout of SCN2A in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
SCN2A
|
cell proliferation
|
T-lymphoma cell line
|
Gene: SCN2A (sodium voltage-gated channel alpha subunit 2)
Type: protein-coding
Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].
Gene Ontology: BP: action potential, cardiac muscle cell action potential involved in contraction, cellular response to hypoxia, intrinsic apoptotic signaling pathway in response to osmotic stress, memory, monoatomic ion transmembrane transport, monoatomic ion transport, myelination, nervous system development, neuron apoptotic process, neuronal action potential, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: calmodulin binding, monoatomic cation channel activity, monoatomic ion channel activity, protein binding, sodium channel activity, voltage-gated sodium channel activity; CC: axon, membrane, monoatomic ion channel complex, node of Ranvier, plasma membrane, voltage-gated sodium channel complex
Pathways: Axon guidance, Cardiac conduction, Developmental Biology, Interaction between L1 and Ankyrins, L1CAM interactions, Muscle contraction, Nervous system development, Phase 0 - rapid depolarisation, Rett syndrome causing genes, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Taste transduction - Homo sapiens (human)
UniProt: Q99250
Entrez ID: 6326
|
Does Knockout of WAC in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
WAC
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: WAC (WW domain containing adaptor with coiled-coil)
Type: protein-coding
Summary: The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].
Gene Ontology: BP: DNA damage response, chromatin organization, chromatin remodeling, mitotic G1 DNA damage checkpoint signaling, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of DNA-templated transcription, positive regulation of TORC1 signaling, positive regulation of macroautophagy, regulation of autophagy; MF: RNA polymerase II complex binding, chromatin binding, protein binding; CC: nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways:
UniProt: Q9BTA9
Entrez ID: 51322
|
Does Knockout of HEATR3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
HEATR3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: HEATR3 (HEAT repeat containing 3)
Type: protein-coding
Summary: The protein encoded by this gene plays a role in ribosomal protein transport and in the assembly of the 5S ribonucleoprotein particle (5S RNP). The encoded protein also may be involved in NOD2-mediated NF-kappaB signaling. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: erythrocyte maturation, protein import into nucleus, ribosomal large subunit biogenesis, ribosome biogenesis
Pathways:
UniProt: Q7Z4Q2
Entrez ID: 55027
|
Does Knockout of ZC3H8 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
ZC3H8
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: ZC3H8 (zinc finger CCCH-type containing 8)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in several processes, including positive regulation of thymocyte apoptotic process; regulation of transcription, DNA-templated; and snRNA transcription. Located in Cajal body; histone locus body; and transcriptionally active chromatin. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: T cell homeostasis, apoptotic process, negative regulation of DNA-templated transcription, negative regulation of T cell differentiation in thymus, negative regulation of transcription by RNA polymerase II, positive regulation of thymocyte apoptotic process, positive regulation of transcription by RNA polymerase III, response to antibiotic, snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III; MF: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: Cajal body, chromatin, euchromatin, histone locus body, nuclear body, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q8N5P1
Entrez ID: 84524
|
Does Knockout of MED7 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
MED7
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MED7 (mediator complex subunit 7)
Type: protein-coding
Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance, transcription initiation at RNA polymerase II promoter; MF: protein binding, transcription coactivator activity, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nuclear body, nucleoplasm, nucleus, transcription regulator complex, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: O43513
Entrez ID: 9443
|
Does Knockout of GLT8D2 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
GLT8D2
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: GLT8D2 (glycosyltransferase 8 domain containing 2)
Type: protein-coding
Summary: Predicted to enable glycosyltransferase activity. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: UDP-glycosyltransferase activity, glycosyltransferase activity, transferase activity; CC: Golgi apparatus, membrane
Pathways:
UniProt: Q9H1C3
Entrez ID: 83468
|
Does Knockout of LEO1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
LEO1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: LEO1 (LEO1 component of Paf1/RNA polymerase II complex)
Type: protein-coding
Summary: LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: Wnt signaling pathway, endodermal cell fate commitment, mRNA 3'-end processing, negative regulation of myeloid cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II; MF: RNA polymerase II C-terminal domain phosphoserine binding, protein binding; CC: Cdc73/Paf1 complex, centrosome, fibrillar center, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Endoderm differentiation, Formation of RNA Pol II elongation complex , Formation of the beta-catenin:TCF transactivating complex, Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q8WVC0
Entrez ID: 123169
|
Does Knockout of DENND4C in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
DENND4C
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: DENND4C (DENN domain containing 4C)
Type: protein-coding
Summary: Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus; protein localization to plasma membrane; and regulation of Rab protein signal transduction. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to insulin stimulus, protein localization to plasma membrane, protein transport, regulation of Rab protein signal transduction; MF: guanyl-nucleotide exchange factor activity; CC: Golgi apparatus, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, insulin-responsive compartment, membrane, plasma membrane, retromer complex
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q5VZ89
Entrez ID: 55667
|
Does Knockout of MCM5 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
MCM5
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: MCM5 (minichromosome maintenance complex component 5)
Type: protein-coding
Summary: The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, DNA replication initiation, double-strand break repair via break-induced replication, regulation of DNA-templated DNA replication initiation; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA replication origin binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: CMG complex, MCM complex, chromosome, chromosome, telomeric region, membrane, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Ciliary landscape, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA strand elongation, Developmental Biology, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, TNFalpha, Unwinding of DNA, cdk regulation of dna replication
UniProt: P33992
Entrez ID: 4174
|
Does Knockout of CHCHD7 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
CHCHD7
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: CHCHD7 (coiled-coil-helix-coiled-coil-helix domain containing 7)
Type: protein-coding
Summary: Predicted to be located in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: mitochondrial intermembrane space, mitochondrion
Pathways: Mitochondrial protein import, Protein localization
UniProt: Q9BUK0
Entrez ID: 79145
|
Does Knockout of DHPS in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
DHPS
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: DHPS (deoxyhypusine synthase)
Type: protein-coding
Summary: This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011].
Gene Ontology: BP: glucose homeostasis, positive regulation of T cell proliferation, positive regulation of cell population proliferation, protein maturation, spermidine catabolic process, spermidine metabolic process, translation; MF: deoxyhypusine synthase activity, identical protein binding, protein binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification, hypusine biosynthesis
UniProt: P49366
Entrez ID: 1725
|
Does Knockout of POU5F1B in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
POU5F1B
|
cell proliferation
|
Cancer Cell Line
|
Gene: POU5F1B (POU class 5 homeobox 1B)
Type: protein-coding
Summary: This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009].
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding; CC: chromatin, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
UniProt: Q06416
Entrez ID: 5462
|
Does Knockout of LILRA2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
LILRA2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: LILRA2 (leukocyte immunoglobulin like receptor A2)
Type: protein-coding
Summary: This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: cell surface receptor signaling pathway, defense response, immune response-regulating signaling pathway, immune system process, innate immune response, innate immune response activating cell surface receptor signaling pathway, interleukin-10-mediated signaling pathway, negative regulation of lipopolysaccharide-mediated signaling pathway, negative regulation of toll-like receptor 4 signaling pathway, neutrophil activation involved in immune response, positive regulation of calcium ion transport, positive regulation of cell activation, positive regulation of granulocyte colony-stimulating factor production, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of tumor necrosis factor production, signal transduction; MF: IgM binding, antigen binding, inhibitory MHC class I receptor activity, signaling receptor activity; CC: extracellular region, membrane, plasma membrane
Pathways: Adaptive Immune System, B cell receptor signaling pathway - Homo sapiens (human), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Osteoclast differentiation - Homo sapiens (human)
UniProt: Q8N149
Entrez ID: 11027
|
Does Knockout of GOLPH3 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
GOLPH3
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: GOLPH3 (golgi phosphoprotein 3)
Type: protein-coding
Summary: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi organization, Golgi ribbon formation, Golgi to plasma membrane protein transport, Golgi vesicle budding, asymmetric Golgi ribbon formation, cell adhesion molecule production, cell migration, cellular response to rapamycin, gene expression, glycoprotein biosynthetic process, lamellipodium assembly, leukocyte tethering or rolling, negative regulation of apoptotic process, positive regulation of TOR signaling, positive regulation of protein secretion, protein retention in Golgi apparatus, protein secretion, protein targeting to Golgi apparatus, protein transport, regulation of mitochondrion organization, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; MF: cargo adaptor activity, enzyme binding, lipid binding, phosphatidylinositol-4-phosphate binding, protein binding; CC: Golgi apparatus, Golgi cisterna, Golgi cisterna membrane, Golgi membrane, cytosol, endosome, membrane, mitochondrial intermembrane space, mitochondrion, plasma membrane, trans-Golgi network
Pathways:
UniProt: Q9H4A6
Entrez ID: 64083
|
Does Knockout of BRAT1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
BRAT1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: BRAT1 (BRCA1 associated ATM activator 1)
Type: protein-coding
Summary: The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: DNA damage response, apoptotic process, cell migration, cell population proliferation, glucose metabolic process, integrator complex assembly, mitochondrion localization, positive regulation of cell growth, positive regulation of protein phosphorylation, protein localization to nucleus, response to ionizing radiation; MF: protein binding, ribonuclease inhibitor activity; CC: cytoplasm, cytosol, membrane, nucleoplasm, nucleus
Pathways:
UniProt: Q6PJG6
Entrez ID: 221927
|
Does Knockout of POU2F3 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
POU2F3
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: POU2F3 (POU class 2 homeobox 3)
Type: protein-coding
Summary: This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: cell differentiation, epidermis development, host-mediated suppression of viral transcription, keratinocyte differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, wound healing; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytosol, nuclear body, nucleolus, nucleoplasm, nucleus, plasma membrane, transcription regulator complex
Pathways: Herpes simplex virus 1 infection - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human)
UniProt: Q9UKI9
Entrez ID: 25833
|
Does Knockout of OPTN in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
OPTN
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: OPTN (optineurin)
Type: protein-coding
Summary: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi organization, Golgi ribbon formation, Golgi to plasma membrane protein transport, autophagy, cell death, cellular response to unfolded protein, defense response to Gram-negative bacterium, immune system process, innate immune response, intracellular protein localization, negative regulation of canonical NF-kappaB signal transduction, negative regulation of receptor recycling, positive regulation of autophagy, positive regulation of xenophagy, protein localization to Golgi apparatus, regulation of canonical NF-kappaB signal transduction, signal transduction, type 2 mitophagy; MF: K63-linked polyubiquitin modification-dependent protein binding, identical protein binding, metal ion binding, polyubiquitin modification-dependent protein binding, protein binding, protein-macromolecule adaptor activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, autophagosome, cytoplasm, cytoplasmic vesicle, cytosol, endosome, nucleoplasm, nucleus, perinuclear region of cytoplasm, recycling endosome, recycling endosome membrane, trans-Golgi network
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Mitophagy - animal - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
UniProt: Q96CV9
Entrez ID: 10133
|
Does Knockout of VPS53 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
VPS53
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: VPS53 (VPS53 subunit of GARP complex)
Type: protein-coding
Summary: This gene encodes a protein with sequence similarity to the yeast Vps53p protein. Vps53p is involved in retrograde vesicle trafficking in late Golgi. [provided by RefSeq, Jul 2008]
Gene Ontology: BP: cytosolic transport, endocytic recycling, lysosomal transport, protein targeting to lysosome, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated cholesterol transport, vesicle-mediated transport; CC: EARP complex, GARP complex, Golgi apparatus, cytosol, endosome, endosome membrane, membrane, perinuclear region of cytoplasm, recycling endosome, trans-Golgi network membrane
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q5VIR6
Entrez ID: 55275
|
Does Activation of TXNDC8 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
TXNDC8
|
response to virus
|
Hepatoma Cell Line
|
Gene: TXNDC8 (thioredoxin domain containing 8)
Type: protein-coding
Summary: Involved in spermatogenesis. Located in Golgi apparatus. Biomarker of male infertility. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, spermatogenesis; CC: Golgi apparatus, acrosomal vesicle, cytoplasm, endomembrane system, extracellular exosome
Pathways:
UniProt: Q6A555
Entrez ID: 255220
|
Does Knockout of WDR90 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
WDR90
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: WDR90 (WD repeat domain 90)
Type: protein-coding
Summary: Involved in cilium assembly. Located in centriole. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell projection organization, centriole elongation, cilium assembly; MF: microtubule binding, protein binding; CC: centriolar satellite, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule, plasma membrane
Pathways:
UniProt: Q96KV7
Entrez ID: 197335
|
Does Knockout of NDUFB6 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
NDUFB6
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NDUFB6 (NADH:ubiquinone oxidoreductase subunit B6)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: aerobic respiration, mitochondrial ATP synthesis coupled electron transport, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: NADH dehydrogenase (ubiquinone) activity, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleoplasm, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human)
UniProt: O95139
Entrez ID: 4712
|
Does Knockout of CASZ1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
CASZ1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CASZ1 (castor zinc finger 1)
Type: protein-coding
Summary: The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of neuron differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: chromatin, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q86V15
Entrez ID: 54897
|
Does Knockout of ARIH1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
ARIH1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Enables enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in Lewy body; cytoplasm; and nuclear body. Colocalizes with cullin-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: PKR/eIFalpha signaling, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-like protein transferase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Cajal body, Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Lewy body, SCF ubiquitin ligase complex, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Disease, ISG15 antiviral mechanism, Immune System, Infectious disease, Interferon Signaling, Modulation of host responses by IFN-stimulated genes, PKR-mediated signaling, RSV-host interactions, Respiratory Syncytial Virus Infection Pathway, Viral Infection Pathways
UniProt: Q9Y4X5
Entrez ID: 25820
|
Does Knockout of INPP4B in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
INPP4B
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: INPP4B (inositol polyphosphate-4-phosphatase type II B)
Type: protein-coding
Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: inositol phosphate metabolic process, lipid metabolic process, phosphatidylinositol biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, signal transduction; MF: hydrolase activity, inositol-1,3,4-trisphosphate 4-phosphatase activity, inositol-3,4-bisphosphate 4-phosphatase activity, phosphatase activity, phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity, protein binding; CC: cytoplasm, cytosol
Pathways: 3-phosphoinositide degradation, Inositol Phosphate Metabolism, Inositol phosphate metabolism, Inositol phosphate metabolism - Homo sapiens (human), Joubert syndrome, Metabolism, Metabolism of lipids, PI Metabolism, Phosphatidylinositol Phosphate Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipid metabolism, Synthesis of IP2, IP, and Ins in the cytosol, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the plasma membrane, VEGFA-VEGFR2 Signaling Pathway
UniProt: O15327
Entrez ID: 8821
|
Does Knockout of RBP7 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
RBP7
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: RBP7 (retinol binding protein 7)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the cellular retinol-binding protein (CRBP) family, whose members are required for vitamin A stability and metabolism. The encoded protein binds all-trans-retinol and is structurally similar to other CRBPs; however, it has a lower binding affinity for retinol than other CRBPs. [provided by RefSeq, Aug 2016].
Gene Ontology: MF: fatty acid binding, lipid binding, protein binding, retinal binding, retinoid binding, retinol binding; CC: cytoplasm, cytosol, nucleus
Pathways: Vitamin A and carotenoid metabolism
UniProt: Q96R05
Entrez ID: 116362
|
Does Knockout of TRIM23 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
TRIM23
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: TRIM23 (tripartite motif containing 23)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: immune system process, innate immune response, intracellular protein transport, positive regulation of autophagy, protein ubiquitination, vesicle-mediated transport; MF: GDP binding, GTP binding, GTPase activity, enzyme activator activity, identical protein binding, metal ion binding, nucleotide binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, endomembrane system, lysosomal membrane, lysosome, membrane, nucleus, plasma membrane
Pathways:
UniProt: P36406
Entrez ID: 373
|
Does Knockout of SF3B5 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
SF3B5
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: SF3B5 (splicing factor 3b subunit 5)
Type: protein-coding
Summary: Enables RNA binding activity and splicing factor binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U12-type spliceosomal complex and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing; MF: RNA binding, protein binding, splicing factor binding; CC: SAGA complex, U12-type spliceosomal complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q9BWJ5
Entrez ID: 83443
|
Does Knockout of FGFR1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
FGFR1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: FGFR1 (fibroblast growth factor receptor 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, angiogenesis, auditory receptor cell development, blood vessel morphogenesis, brain development, branching involved in salivary gland morphogenesis, calcium ion homeostasis, cardiac muscle cell proliferation, cell maturation, cell migration, cell population proliferation, cell projection assembly, cellular response to fibroblast growth factor stimulus, cementum mineralization, chondrocyte differentiation, chordate embryonic development, diphosphate metabolic process, ear development, embryonic limb morphogenesis, epithelial to mesenchymal transition, fibroblast growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development, gene expression, generation of neurons, in utero embryonic development, inner ear morphogenesis, lung development, lung-associated mesenchyme development, mesenchymal cell differentiation, mesenchymal cell proliferation, midbrain development, middle ear morphogenesis, negative regulation of fibroblast growth factor production, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, neuron migration, neuron projection development, orbitofrontal cortex development, organ induction, outer ear morphogenesis, paraxial mesoderm development, peptidyl-tyrosine phosphorylation, phosphatidylinositol-mediated signaling, positive regulation of MAP kinase activity, positive regulation of MAPK cascade, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation of blood vessel endothelial cell migration, positive regulation of cardiac muscle cell proliferation, positive regulation of cell cycle, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of endothelial cell chemotaxis, positive regulation of macromolecule metabolic process, positive regulation of mesenchymal cell proliferation, positive regulation of mitotic cell cycle DNA replication, positive regulation of neuron differentiation, positive regulation of neuron projection development, positive regulation of parathyroid hormone secretion, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of phospholipase activity, positive regulation of stem cell proliferation, positive regulation of vascular endothelial cell proliferation, protein autophosphorylation, protein phosphorylation, regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling, regulation of cell differentiation, regulation of epithelial cell proliferation, regulation of extrinsic apoptotic signaling pathway in absence of ligand, regulation of gene expression, regulation of lateral mesodermal cell fate specification, regulation of phosphate transport, regulation of phosphorus metabolic process, regulation of postsynaptic density assembly, regulation of primary metabolic process, response to sodium phosphate, salivary gland morphogenesis, sensory perception of sound, skeletal system development, skeletal system morphogenesis, stem cell differentiation, stem cell proliferation, ureteric bud development, ventricular zone neuroblast division, vitamin D3 metabolic process; MF: ATP binding, SH2 domain binding, fibroblast growth factor binding, fibroblast growth factor receptor activity, heparin binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein tyrosine kinase activity, receptor-receptor interaction, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: cytoplasm, cytoplasmic vesicle, cytosol, extracellular region, glutamatergic synapse, membrane, nucleus, plasma membrane, postsynapse, receptor complex
Pathways: 22q11.2 copy number variation syndrome, Adherens junction - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, Calcium signaling pathway - Homo sapiens (human), Central carbon metabolism in cancer - Homo sapiens (human), ESC Pluripotency Pathways, Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, Endometrial cancer, FGF signaling pathway, Fibroblast growth factor-1, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glioblastoma signaling pathways, Glypican 1 network, Head and Neck Squamous Cell Carcinoma, Hippo-Merlin Signaling Dysregulation, Kallmann,s Syndrome, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Melanoma - Homo sapiens (human), Mesodermal commitment pathway, N-cadherin signaling events, Neural Crest Differentiation, Osteoblast differentiation, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Pathways Regulating Hippo Signaling, Pathways in cancer - Homo sapiens (human), Posttranslational regulation of adherens junction stability and dissassembly, Prion disease pathway, Prostate cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Syndecan-1-mediated signaling events, Syndecan-2-mediated signaling events, Syndecan-3-mediated signaling events, Syndecan-4-mediated signaling events, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects
UniProt: P11362
Entrez ID: 2260
|
Does Knockout of ELP1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
ELP1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: ELP1 (elongator acetyltransferase complex subunit 1)
Type: protein-coding
Summary: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: regulation of translation, tRNA processing, tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation, tRNA wobble uridine modification; MF: protein binding, tRNA binding; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, IL1, TNFalpha
UniProt: O95163
Entrez ID: 8518
|
Does Knockout of OLFML1 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
OLFML1
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: OLFML1 (olfactomedin like 1)
Type: protein-coding
Summary: Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q6UWY5
Entrez ID: 283298
|
Does Knockout of POLR2H in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
POLR2H
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: POLR2H (RNA polymerase II, I and III subunit H)
Type: protein-coding
Summary: The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: DNA-templated transcription, transcription by RNA polymerase II; MF: DNA binding, DNA-directed RNA polymerase activity, single-stranded DNA binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, RNA polymerase II, core complex, RNA polymerase III complex, cytosol, nucleolus, nucleoplasm, nucleus, protein-DNA complex
Pathways: Abortive elongation of HIV-1 transcript in the absence of Tat, Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, B-WICH complex positively regulates rRNA expression, Cell Cycle, Chromosome Maintenance, Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , DNA Repair, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dual incision in TC-NER, ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, Eukaryotic Transcription Initiation, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene Silencing by RNA, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, HIV elongation arrest and recovery, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inhibition of DNA recombination at telomere, Innate Immune System, Late Phase of HIV Life Cycle, Metabolism of RNA, MicroRNA (miRNA) biogenesis, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, PIWI-interacting RNA (piRNA) biogenesis, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, Positive epigenetic regulation of rRNA expression, Processing of Capped Intron-Containing Pre-mRNA, Pyrimidine metabolism, RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TNFalpha, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Telomere Maintenance, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by small RNAs, Viral Infection Pathways, Viral Messenger RNA Synthesis, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P52434
Entrez ID: 5437
|
Does Knockout of USP14 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
USP14
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: USP14 (ubiquitin specific peptidase 14)
Type: protein-coding
Summary: This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chemical synaptic transmission, immune system process, inflammatory response, innate immune response, negative regulation of ERAD pathway, negative regulation of ubiquitin-dependent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked deubiquitination, protein deubiquitination, proteolysis, regulation of chemotaxis, regulation of proteasomal protein catabolic process; MF: K63-linked deubiquitinase activity, cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, deubiquitinase activity, endopeptidase inhibitor activity, hydrolase activity, peptidase activity, proteasome binding, protein binding; CC: cell surface, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, extracellular exosome, glutamatergic synapse, membrane, nucleolus, plasma membrane, presynaptic cytosol, proteasome complex, synapse
Pathways: Cytokine Signaling in Immune system, Deubiquitination, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Post-translational protein modification, Regulation of NF-kappa B signaling, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ub-specific processing proteases
UniProt: P54578
Entrez ID: 9097
|
Does Knockout of HOXA11 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
HOXA11
|
response to virus
|
Hepatoma Cell Line
|
Gene: HOXA11 (homeobox A11)
Type: protein-coding
Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anatomical structure morphogenesis, anterior/posterior pattern specification, bone development, branching involved in ureteric bud morphogenesis, cartilage development involved in endochondral bone morphogenesis, cell development, chondrocyte development, chondrocyte differentiation, developmental growth, dorsal/ventral pattern formation, embryonic digit morphogenesis, embryonic forelimb morphogenesis, embryonic limb morphogenesis, embryonic skeletal joint morphogenesis, male gonad development, mesodermal cell fate specification, metanephros development, organ induction, positive regulation of DNA-templated transcription, positive regulation of cell development, positive regulation of chondrocyte development, positive regulation of chondrocyte differentiation, prostate gland development, proximal/distal pattern formation, regulation of DNA-templated transcription, regulation of chondrocyte differentiation, regulation of gene expression, regulation of transcription by RNA polymerase II, response to estrogen, response to testosterone, single fertilization, skeletal system development, spermatogenesis, uterus development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, transcription regulator complex
Pathways: Development of ureteric collection system, Developmental Biology, Formation of the ureteric bud, Genes controlling nephrogenesis, Kidney development, Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: P31270
Entrez ID: 3207
|
Does Knockout of RPL10A in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
RPL10A
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: RPL10A (ribosomal protein L10a)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, response to ethanol, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, large ribosomal subunit, membrane, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, VEGFA-VEGFR2 Signaling Pathway, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62906
Entrez ID: 4736
|
Does Knockout of SHTN1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
SHTN1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: SHTN1 (shootin 1)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in positive regulation of neuron migration. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Cdc42 protein signal transduction, Ras protein signal transduction, actin filament bundle retrograde transport, axonogenesis, cytoplasmic actin-based contraction involved in cell motility, endoplasmic reticulum polarization, netrin-activated signaling pathway, neuron projection morphogenesis, positive regulation of axon extension, positive regulation of neuron migration, regulation of establishment of cell polarity, regulation of neuron migration, substrate-dependent cell migration, cell extension; MF: actin filament binding, cadherin binding, identical protein binding, kinesin binding, protein binding; CC: axon, axonal growth cone, cell leading edge, cell projection, cytoplasm, cytoskeleton, filopodium, growth cone, lamellipodium, microtubule, microtubule associated complex, microtubule cytoskeleton, perikaryon, perinuclear region of cytoplasm
Pathways: Axon guidance, Developmental Biology, L1CAM interactions, Nervous system development, Recycling pathway of L1
UniProt: A0MZ66
Entrez ID: 57698
|
Does Knockout of RNF212 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
RNF212
|
response to virus
|
Huh-7 Cell
|
Gene: RNF212 (ring finger protein 212)
Type: protein-coding
Summary: This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010].
Gene Ontology: BP: chiasma assembly, homologous chromosome pairing at meiosis, meiotic cell cycle, meiotic gene conversion, protein sumoylation, reciprocal meiotic recombination; MF: SUMO transferase activity, metal ion binding, transferase activity, zinc ion binding; CC: chromosome, nucleus, synaptonemal complex
Pathways:
UniProt: Q495C1
Entrez ID: 285498
|
Does Knockout of ANPEP in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
ANPEP
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ANPEP (alanyl aminopeptidase, membrane)
Type: protein-coding
Summary: Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma. [provided by RefSeq, Apr 2020].
Gene Ontology: BP: angiogenesis, angiotensin maturation, cell differentiation, peptide catabolic process, proteolysis, symbiont entry into host cell; MF: alanyl aminopeptidase activity, aminopeptidase activity, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptidase activity, signaling receptor activity, virus receptor activity, zinc ion binding; CC: endoplasmic reticulum-Golgi intermediate compartment, external side of plasma membrane, extracellular exosome, extracellular space, lysosomal membrane, membrane, plasma membrane, secretory granule membrane
Pathways: 5-Oxoprolinuria, 5-oxoprolinase deficiency, C-MYB transcription factor network, Cardiac Progenitor Differentiation, Gamma-Glutamyltransferase Deficiency, Gamma-glutamyl-transpeptidase deficiency, Glutathione Metabolism, Glutathione Synthetase Deficiency, Glutathione metabolism, Glutathione metabolism - Homo sapiens (human), Hematopoietic cell lineage - Homo sapiens (human), Immune System, Innate Immune System, Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, Neutrophil degranulation, Peptide hormone metabolism, Renin-angiotensin system - Homo sapiens (human), glutathione-mediated detoxification
UniProt: P15144
Entrez ID: 290
|
Does Knockout of ACTR10 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
ACTR10
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: ACTR10 (actin related protein 10)
Type: protein-coding
Summary: Predicted to be involved in retrograde axonal transport of mitochondrion. Predicted to be located in cytosol; extracellular region; and secretory granule. Predicted to be part of dynactin complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: microtubule-based movement, retrograde axonal transport of mitochondrion; CC: axon cytoplasm, azurophil granule lumen, cytoplasm, cytoskeleton, cytosol, dynactin complex, extracellular region, ficolin-1-rich granule lumen
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Salmonella infection - Homo sapiens (human), TCR, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9NZ32
Entrez ID: 55860
|
Does Knockout of NOD1 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
NOD1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: NOD1 (nucleotide binding oligomerization domain containing 1)
Type: protein-coding
Summary: This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: ERK1 and ERK2 cascade, JNK cascade, apoptotic process, cellular response to muramyl dipeptide, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, detection of bacterium, detection of biotic stimulus, immune system process, inflammatory response, innate immune response, intracellular signal transduction, nucleotide-binding oligomerization domain containing 1 signaling pathway, pattern recognition receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of apoptotic process, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cytokine production, positive regulation of dendritic cell antigen processing and presentation, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of macrophage cytokine production, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of stress-activated MAPK cascade, positive regulation of tumor necrosis factor production, positive regulation of xenophagy, regulation of apoptotic process, response to endoplasmic reticulum stress, signal transduction, stress-activated MAPK cascade, xenophagy; MF: ATP binding, CARD domain binding, cysteine-type endopeptidase activator activity involved in apoptotic process, identical protein binding, nucleotide binding, pattern recognition receptor activity, peptidoglycan binding, protein binding, protein homodimerization activity, protein-containing complex binding, ubiquitin binding; CC: apical plasma membrane, basolateral plasma membrane, cytoplasm, cytosol, membrane, phagocytic vesicle, plasma membrane
Pathways: Cytokine Signaling in Immune system, Deubiquitination, Disease, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, MAP kinase activation, Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NOD-like receptor signaling pathway - Homo sapiens (human), NOD1/2 Signaling Pathway, Nucleotide-binding Oligomerization Domain (NOD) pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Ovarian tumor domain proteases, Pertussis - Homo sapiens (human), Post-translational protein modification, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Viral Infection Pathways, activated TAK1 mediates p38 MAPK activation
UniProt: Q9Y239
Entrez ID: 10392
|
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