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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of DNASE2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
DNASE2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DNASE2 (deoxyribonuclease 2, lysosomal)
Type: protein-coding
Summary: This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA catabolic process, DNA metabolic process, apoptotic DNA fragmentation, apoptotic process, enucleate erythrocyte differentiation, regulation of immune response; MF: DNA binding, DNA endonuclease activity, deoxyribonuclease II activity, endonuclease activity, hydrolase activity, nuclease activity, protein binding; CC: extracellular exosome, lysosome
Pathways: Lysosome - Homo sapiens (human), Lysosome Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: O00115
Entrez ID: 1777
|
Does Knockout of GTF2E1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
GTF2E1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: GTF2E1 (general transcription factor IIE subunit 1)
Type: protein-coding
Summary: Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of transcription factor TFIID complex and transcription preinitiation complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: RNA polymerase II general transcription initiation factor activity, metal ion binding, protein binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIE complex
Pathways: Basal transcription factors - Homo sapiens (human), Disease, Eukaryotic Transcription Initiation, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Transcription of the HIV genome, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), carm1 and regulation of the estrogen receptor, chromatin remodeling by hswi/snf atp-dependent complexes, the information processing pathway at the ifn beta enhancer
UniProt: P29083
Entrez ID: 2960
|
Does Knockout of EYS in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
EYS
|
cell proliferation
|
Melanoma Cell Line
|
Gene: EYS (EGF-like photoreceptor maintenance factor)
Type: protein-coding
Summary: The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
Gene Ontology: BP: detection of light stimulus involved in visual perception, developmental growth, nervous system process, skeletal muscle tissue regeneration, visual perception; CC: cell projection, centrosome, cilium, cytoplasm, cytoskeleton, extracellular exosome, extracellular region, interphotoreceptor matrix, photoreceptor outer segment
Pathways:
UniProt: Q5T1H1
Entrez ID: 346007
|
Does Knockout of PROCR in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
PROCR
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PROCR (protein C receptor)
Type: protein-coding
Summary: The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: blood coagulation, hemostasis, negative regulation of coagulation; MF: protein binding, signaling receptor activity; CC: cell surface, centrosome, extracellular exosome, extracellular region, extracellular space, focal adhesion, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Cell surface interactions at the vascular wall, Common Pathway of Fibrin Clot Formation, Complement and coagulation cascades - Homo sapiens (human), Formation of Fibrin Clot (Clotting Cascade), Hemostasis, transcriptional activation of dbpb from mrna
UniProt: Q9UNN8
Entrez ID: 10544
|
Does Knockout of TRAPPC1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
TRAPPC1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: TRAPPC1 (trafficking protein particle complex subunit 1)
Type: protein-coding
Summary: This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, azurophil granule lumen, cytoplasm, cytosol, endoplasmic reticulum, extracellular region
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9Y5R8
Entrez ID: 58485
|
Does Knockout of SUCNR1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
SUCNR1
|
response to virus
|
Hepatoma Cell Line
|
Gene: SUCNR1 (succinate receptor 1)
Type: protein-coding
Summary: This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, energy homeostasis, glucose homeostasis, macrophage activation involved in immune response, positive regulation of chemotaxis, positive regulation of inflammatory response, regulation of angiotensin metabolic process, renin secretion into blood stream, response to calcium ion, signal transduction; MF: G protein-coupled receptor activity, protein binding, signaling receptor activity; CC: extracellular exosome, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Homo sapiens (human)
UniProt: Q9BXA5
Entrez ID: 56670
|
Does Knockout of DNM3 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
DNM3
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DNM3 (dynamin 3)
Type: protein-coding
Summary: This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
Gene Ontology: BP: endocytosis, filopodium assembly, synapse assembly, synaptic vesicle budding from presynaptic endocytic zone membrane; MF: GTP binding, GTPase activity, hydrolase activity, identical protein binding, microtubule binding, nucleotide binding, protein binding; CC: cytoplasm, cytoskeleton, dendritic spine, extracellular exosome, microtubule, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, presynapse, synapse
Pathways: Bacterial invasion of epithelial cells - Homo sapiens (human), Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), Endocytosis - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Synaptic Vesicle Pathway, Synaptic vesicle cycle - Homo sapiens (human)
UniProt: Q9UQ16
Entrez ID: 26052
|
Does Knockout of PSMC3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
PSMC3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PSMC3 (proteasome 26S subunit, ATPase 3)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: blastocyst development, host-mediated perturbation of viral transcription, positive regulation of proteasomal protein catabolic process, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATP binding, ATP hydrolysis activity, identical protein binding, nucleotide binding, proteasome-activating activity, protein binding; CC: P-body, cytoplasm, cytosol, extracellular region, ficolin-1-rich granule lumen, membrane, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P17980
Entrez ID: 5702
|
Does Knockout of PDAP1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
PDAP1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PDAP1 (PDGFA associated protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010].
Gene Ontology: MF: RNA binding, protein binding; CC: cytosol, extracellular region, ficolin-1-rich granule lumen, plasma membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q13442
Entrez ID: 11333
|
Does Knockout of RPSA in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
RPSA
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPSA (ribosomal protein SA)
Type: protein-coding
Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: antiviral innate immune response, cell adhesion, chromatin remodeling, cytoplasmic translation, ribosomal small subunit assembly, symbiont entry into host cell, translation; MF: DNA binding, RNA binding, laminin binding, laminin receptor activity, protein binding, ribosome binding, structural constituent of ribosome, virus receptor activity; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, membrane, nucleoplasm, nucleus, plasma membrane, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Alpha6Beta4Integrin, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, prion pathway, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P08865
Entrez ID: 3921
|
Does Knockout of ZNF90 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
ZNF90
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ZNF90 (zinc finger protein 90)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Herpes simplex virus 1 infection - Homo sapiens (human)
UniProt: Q03938
Entrez ID: 7643
|
Does Knockout of BCCIP in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
BCCIP
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: BCCIP (BRCA2 and CDKN1A interacting protein)
Type: protein-coding
Summary: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, establishment of mitotic spindle orientation, microtubule anchoring, microtubule cytoskeleton organization, mitotic spindle assembly, mitotic spindle organization, neuroendocrine cell differentiation, regulation of cyclin-dependent protein serine/threonine kinase activity; MF: RNA binding, kinase regulator activity, protein binding, tubulin binding; CC: centriole, centrosome, cytoplasm, cytoskeleton, cytosol, mitotic spindle pole, nuclear cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: Q9P287
Entrez ID: 56647
|
Does Knockout of PIK3R5 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
PIK3R5
|
cell proliferation
|
Bladder Carcinoma
|
Gene: PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5)
Type: protein-coding
Summary: Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, immune response, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol metabolic process, positive regulation of MAP kinase activity, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: 1-phosphatidylinositol-3-kinase regulator activity, G-protein beta/gamma-subunit complex binding; CC: centriolar satellite, cytoplasm, cytosol, membrane, nucleus, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex, class IB, plasma membrane
Pathways: 3-phosphoinositide biosynthesis, Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Apelin signaling pathway - Homo sapiens (human), CD28 dependent PI3K/Akt signaling, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Co-stimulation by CD28, Co-stimulation by ICOS, Constitutive Signaling by Aberrant PI3K in Cancer, DNA damage response (only ATM dependent), Disease, Diseases of signal transduction by growth factor receptors and second messengers, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Extracellular vesicle-mediated signaling in recipient cells, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, G beta:gamma signalling through PI3Kgamma, G-protein beta:gamma signalling, GPCR downstream signalling, GPVI-mediated activation cascade, Head and Neck Squamous Cell Carcinoma, Hemostasis, Immune System, Intracellular signaling by second messengers, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Metabolism, Metabolism of lipids, Negative regulation of the PI3K/AKT network, Neural Crest Cell Migration during Development, Neural Crest Cell Migration in Cancer, Osteoblast differentiation, Oxytocin signaling pathway - Homo sapiens (human), PI Metabolism, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Phospholipase D signaling pathway - Homo sapiens (human), Phospholipid metabolism, Platelet activation - Homo sapiens (human), Platelet activation, signaling and aggregation, Regulation of Actin Cytoskeleton, Regulation of T cell activation by CD28 family, Regulation of toll-like receptor signaling pathway, Signal Transduction, Signaling by Erythropoietin, Signaling by GPCR, Synthesis of PIPs at the plasma membrane, Toll-like Receptor Signaling Pathway, Toxoplasmosis - Homo sapiens (human), Type II diabetes mellitus, cGMP-PKG signaling pathway - Homo sapiens (human), superpathway of inositol phosphate compounds
UniProt: Q8WYR1
Entrez ID: 23533
|
Does Knockout of DDX39B in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
DDX39B
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: DDX39B (DExD-box helicase 39B)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: RNA export from nucleus, RNA splicing, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, spliceosomal complex assembly; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on RNA, ATP-dependent protein binding, RNA binding, RNA helicase activity, U4 snRNA binding, U6 snRNA binding, helicase activity, hydrolase activity, identical protein binding, mRNA binding, nucleic acid binding, nucleotide binding, protein binding; CC: U4 snRNP, U6 snRNP, cytoplasm, nuclear speck, nucleoplasm, nucleus, spliceosomal complex, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, RNA transport - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q13838
Entrez ID: 7919
|
Does Knockout of FXYD4 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
FXYD4
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: FXYD4 (FXYD domain containing ion transport regulator 4)
Type: protein-coding
Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010].
Gene Ontology: BP: monoatomic ion transport, positive regulation of sodium ion export across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of monoatomic ion transport, sodium ion transport; MF: ATPase binding, ion channel regulator activity, sodium channel regulator activity; CC: basolateral plasma membrane, membrane, plasma membrane, sodium:potassium-exchanging ATPase complex
Pathways: Aldosterone-regulated sodium reabsorption - Homo sapiens (human), Cardiac conduction, Disease, Infectious disease, Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Muscle contraction, Potential therapeutics for SARS, SARS-CoV Infections, Transport of small molecules, Viral Infection Pathways
UniProt: P59646
Entrez ID: 53828
|
Does Knockout of BOD1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
BOD1
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: BOD1 (biorientation of chromosomes in cell division 1)
Type: protein-coding
Summary: Enables protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Involved in mitotic sister chromatid segregation; negative regulation of phosphoprotein phosphatase activity; and protein localization to chromosome, centromeric region. Located in centrosome; spindle microtubule; and spindle pole. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, mitotic metaphase chromosome alignment, mitotic sister chromatid biorientation, mitotic sister chromatid cohesion, centromeric, protein localization to chromosome, centromeric region; MF: protein binding, protein phosphatase 2A binding, protein phosphatase inhibitor activity; CC: Set1C/COMPASS complex, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, kinetochore, nucleoplasm, outer kinetochore, spindle microtubule, spindle pole
Pathways:
UniProt: Q96IK1
Entrez ID: 91272
|
Does Knockout of RPL12 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
RPL12
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: RPL12 (ribosomal protein L12)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, large ribosomal subunit rRNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, membrane, postsynaptic density, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P30050
Entrez ID: 6136
|
Does Knockout of PCNA in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
PCNA
|
cell proliferation
|
Cancer Cell Line
|
Gene: PCNA (proliferating cell nuclear antigen)
Type: protein-coding
Summary: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, base-excision repair, gap-filling, cellular response to UV, cellular response to hydrogen peroxide, cellular response to xenobiotic stimulus, chromatin organization, epithelial cell differentiation, estrous cycle, heart development, leading strand elongation, liver regeneration, mismatch repair, mitotic telomere maintenance via semi-conservative replication, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regulation of DNA replication, positive regulation of DNA-directed DNA polymerase activity, positive regulation of deoxyribonuclease activity, regulation of DNA replication, replication fork processing, response to L-glutamate, response to cadmium ion, response to dexamethasone, response to estradiol, response to lipid, response to oxidative stress, translesion synthesis; MF: DNA binding, DNA polymerase binding, DNA polymerase processivity factor activity, MutLalpha complex binding, chromatin binding, damaged DNA binding, dinucleotide insertion or deletion binding, enzyme binding, histone acetyltransferase binding, identical protein binding, nuclear estrogen receptor binding, protein binding, protein-containing complex binding, purine-specific mismatch base pair DNA N-glycosylase activity, receptor tyrosine kinase binding; CC: PCNA complex, PCNA-p21 complex, centrosome, chromatin, chromosome, telomeric region, cyclin-dependent protein kinase holoenzyme complex, extracellular exosome, male germ cell nucleus, nuclear body, nuclear lamina, nuclear replication fork, nucleoplasm, nucleus, replication fork, replisome
Pathways: 16p11.2 proximal deletion syndrome, BARD1 signaling events, Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Direct p53 effectors, Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, EGF-EGFR signaling pathway, Extension of Telomeres, G0 and Early G1, G1 to S cell cycle control, G1/S Transition, G1/S-Specific Transcription, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Metabolism of proteins, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Homo sapiens (human), Mitotic G1 phase and G1/S transition, Nucleotide Excision Repair, Nucleotide Excision Repair , Nucleotide excision repair - Homo sapiens (human), Oxidative Damage, PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Post-translational protein modification, Primary focal segmental glomerulosclerosis (FSGS), Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Protein ubiquitination, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), Retinoblastoma gene in cancer, S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Senescence and Autophagy in Cancer, Synthesis of DNA, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Tight junction - Homo sapiens (human), Transcription of E2F targets under negative control by DREAM complex, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Validated nuclear estrogen receptor alpha network, il-2 receptor beta chain in t cell activation, p53 signaling pathway
UniProt: P12004
Entrez ID: 5111
|
Does Knockout of ATG10 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
ATG10
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ATG10 (autophagy related 10)
Type: protein-coding
Summary: Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: ER overload response, autophagosome assembly, autophagy, mitophagy, protein modification by small protein conjugation, protein transport; MF: Atg12 conjugating enzyme activity, Atg12 transferase activity, protein binding, transferase activity, ubiquitin-like protein transferase activity; CC: cytoplasm, cytosol
Pathways: Autophagy, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), Macroautophagy, Nanoparticle triggered autophagic cell death, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Senescence and Autophagy in Cancer
UniProt: Q9H0Y0
Entrez ID: 83734
|
Does Knockout of MAPK8IP3 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
MAPK8IP3
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3)
Type: protein-coding
Summary: The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, anterograde axonal protein transport, axon development, axon regeneration, negative regulation of apoptotic process, positive regulation of JNK cascade, protein stabilization, regulation of JNK cascade, vesicle-mediated transport; MF: JUN kinase binding, MAP-kinase scaffold activity, kinesin binding, protein binding, signaling receptor complex adaptor activity; CC: Golgi apparatus, Golgi membrane, axon, axon cytoplasm, cell body, cell projection, cytoplasm, cytoplasmic vesicle, dendrite, growth cone, perinuclear region of cytoplasm
Pathways: Arf6 trafficking events, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Signaling events mediated by focal adhesion kinase
UniProt: Q9UPT6
Entrez ID: 23162
|
Does Knockout of CNPY2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
CNPY2
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: CNPY2 (canopy FGF signaling regulator 2)
Type: protein-coding
Summary: Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of gene expression, regulation of low-density lipoprotein particle clearance; CC: endoplasmic reticulum
Pathways:
UniProt: Q9Y2B0
Entrez ID: 10330
|
Does Knockout of MRC2 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
MRC2
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: MRC2 (mannose receptor C-type 2)
Type: protein-coding
Summary: This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: collagen catabolic process, endocytosis, osteoblast differentiation; MF: carbohydrate binding, collagen binding, protein binding, signaling receptor activity; CC: focal adhesion, membrane
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, Cross-presentation of soluble exogenous antigens (endosomes), Immune System, Phagosome - Homo sapiens (human), Tuberculosis - Homo sapiens (human)
UniProt: Q9UBG0
Entrez ID: 9902
|
Does Knockout of CLDN18 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
CLDN18
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: CLDN18 (claudin 18)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: bicellular tight junction assembly, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion, cellular response to estrogen stimulus, digestive tract development, epithelial cell proliferation, epithelial fluid transport, lung alveolus development, negative regulation of bone resorption, negative regulation of osteoclast development, negative regulation of protein localization to nucleus, negative regulation of tumor necrosis factor-mediated signaling pathway, organ growth, protein localization to nucleus, response to ethanol, tight junction organization; MF: identical protein binding, protein binding, structural molecule activity; CC: anchoring junction, bicellular tight junction, cell-cell junction, lateral plasma membrane, membrane, plasma membrane, tight junction
Pathways: Cell adhesion molecules - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Epithelial to mesenchymal transition in colorectal cancer, Hepatitis C - Homo sapiens (human), Leukocyte transendothelial migration - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Tight junction - Homo sapiens (human), Tight junction interactions
UniProt: P56856
Entrez ID: 51208
|
Does Knockout of GJB1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
GJB1
|
cell proliferation
|
Cancer Cell Line
|
Gene: GJB1 (gap junction protein beta 1)
Type: protein-coding
Summary: This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: cell communication, cell-cell signaling, gap junction assembly, nervous system development, transmembrane transport; MF: gap junction channel activity, identical protein binding, protein binding; CC: anchoring junction, connexin complex, cytoplasm, endoplasmic reticulum membrane, gap junction, membrane, plasma membrane
Pathways: Calcium Regulation in the Cardiac Cell, Common Pathways Underlying Drug Addiction, Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Neural Crest Differentiation, Oligomerization of connexins into connexons, Transport of connexins along the secretory pathway, Vesicle-mediated transport
UniProt: P08034
Entrez ID: 2705
|
Does Knockout of NR0B1 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
NR0B1
|
response to virus
|
Lung Cancer Cell Line
|
Gene: NR0B1 (nuclear receptor subfamily 0 group B member 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Leydig cell differentiation, Sertoli cell differentiation, adrenal gland development, developmental process involved in reproduction, endodermal cell differentiation, gonad development, hypothalamus development, intracellular protein localization, male gonad development, male sex determination, negative regulation of DNA-templated transcription, negative regulation of gluconeogenesis, negative regulation of intracellular steroid hormone receptor signaling pathway, negative regulation of steroid biosynthetic process, negative regulation of transcription by RNA polymerase II, pituitary gland development, response to immobilization stress, sex determination, spermatogenesis; MF: AF-2 domain binding, DNA hairpin binding, RNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, nuclear receptor binding, nucleic acid binding, protein binding, protein domain specific binding, protein homodimerization activity, transcription corepressor activity; CC: centriolar satellite, chromatin, cytoplasm, membrane, nuclear speck, nucleoplasm, nucleus, ribosome
Pathways: Cortisol synthesis and secretion - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, Nuclear receptors, RNA Polymerase II Transcription, Regulation of Androgen receptor activity, Validated nuclear estrogen receptor alpha network, Validated nuclear estrogen receptor beta network
UniProt: P51843
Entrez ID: 190
|
Does Knockout of ATF4 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
ATF4
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: ATF4 (activating transcription factor 4)
Type: protein-coding
Summary: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: GDF15-GFRAL signaling pathway, HRI-mediated signaling, L-asparagine metabolic process, PERK-mediated unfolded protein response, bone mineralization, cellular response to UV, cellular response to amino acid starvation, cellular response to glucose starvation, cellular response to hypoxia, cellular response to leucine starvation, cellular response to oxidative stress, circadian regulation of gene expression, circadian rhythm, embryonic hemopoiesis, endoplasmic reticulum unfolded protein response, gamma-aminobutyric acid signaling pathway, gluconeogenesis, integrated stress response signaling, intracellular calcium ion homeostasis, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, lens fiber cell morphogenesis, mRNA transcription by RNA polymerase II, mitochondrial respirasome assembly, negative regulation of cold-induced thermogenesis, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of potassium ion transport, negative regulation of transcription by RNA polymerase II, negative regulation of translational initiation in response to stress, neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of biomineral tissue development, positive regulation of gene expression, positive regulation of neuron apoptotic process, positive regulation of sodium-dependent phosphate transport, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular endothelial growth factor production, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of osteoblast differentiation, regulation of synaptic plasticity, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to manganese-induced endoplasmic reticulum stress, response to nutrient levels, response to toxic substance, rhythmic process, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding protein binding, general transcription initiation factor binding, identical protein binding, leucine zipper domain binding, promoter-specific chromatin binding, protein binding, protein heterodimerization activity, protein kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: ATF1-ATF4 transcription factor complex, ATF4-CREB1 transcription factor complex, CHOP-ATF4 complex, Lewy body core, RNA polymerase II transcription regulator complex, centrosome, chromatin, cytoplasm, cytoskeleton, cytosol, dendrite membrane, membrane, mitochondrion, neuron projection, nuclear periphery, nuclear speck, nucleoplasm, nucleus, plasma membrane, protein-containing complex, transcription regulator complex
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, ATF6 (ATF6-alpha) activates chaperone genes, ATF6 (ATF6-alpha) activates chaperones, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alcoholism - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Amphetamine addiction - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis - Homo sapiens (human), Cellular response to chemical stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Cholinergic synapse - Homo sapiens (human), Cocaine addiction - Homo sapiens (human), Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Dopaminergic synapse - Homo sapiens (human), Estrogen signaling pathway - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glucagon signaling pathway - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Joubert Syndrome, KEAP1-NFE2L2 pathway, Lipid and atherosclerosis - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), Longevity regulating pathway - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mitophagy - animal - Homo sapiens (human), Myometrial relaxation and contraction pathways, NFE2L2 regulating ER-stress associated genes, NFE2L2 regulating anti-oxidant/detoxification enzymes, Neurotrophin signaling pathway - Homo sapiens (human), Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Nuclear events mediated by NFE2L2, PERK regulates gene expression, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Photodynamic therapy-induced unfolded protein response, Prion disease - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Renin-angiotensin-aldosterone system (RAAS), Response of EIF2AK1 (HRI) to heme deficiency, Response of EIF2AK4 (GCN2) to amino acid deficiency, TNF signaling pathway - Homo sapiens (human), Thyroid hormone synthesis - Homo sapiens (human), Unfolded Protein Response (UPR), Unfolded protein response, VEGFA-VEGFR2 Signaling Pathway, Validated transcriptional targets of AP1 family members Fra1 and Fra2, Viral carcinogenesis - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P18848
Entrez ID: 468
|
Does Knockout of TWIST2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
TWIST2
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: TWIST2 (twist family bHLH transcription factor 2)
Type: protein-coding
Summary: The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: cell differentiation, developmental process, negative regulation of DNA-templated transcription, negative regulation of osteoblast differentiation, positive regulation of cell migration, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity; CC: cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Epithelial to mesenchymal transition in colorectal cancer, Gene expression (Transcription), Generic Transcription Pathway, Negative Regulation of CDH1 Gene Transcription, Proteoglycans in cancer - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Transcriptional regulation by RUNX2
UniProt: Q8WVJ9
Entrez ID: 117581
|
Does Knockout of ETF1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
ETF1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ETF1 (eukaryotic translation termination factor 1)
Type: protein-coding
Summary: This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: cytoplasmic translational termination, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, protein methylation, regulation of translational termination, ribosome disassembly, translation, translational termination; MF: RNA binding, peptidyl-tRNA hydrolase activity, protein binding, ribosome binding, sequence-specific mRNA binding, translation release factor activity, translation release factor activity, codon specific, translation termination factor activity; CC: cytoplasm, cytosol, cytosolic ribosome, nucleus, translation release factor complex
Pathways: Axon guidance, Developmental Biology, Eukaryotic Translation Termination, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of RNA, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Post-translational protein modification, Protein hydroxylation, Regulation of expression of SLITs and ROBOs, Signaling by ROBO receptors, Translation, Translation Factors, mRNA surveillance pathway - Homo sapiens (human)
UniProt: P62495
Entrez ID: 2107
|
Does Knockout of SRP54 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
SRP54
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SRP54 (signal recognition particle 54)
Type: protein-coding
Summary: Enables several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Contributes to GTPase activity. Involved in granulocyte differentiation and protein targeting to ER. Located in cytosol and nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. Implicated in severe congenital neutropenia 8. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, SRP-dependent cotranslational protein targeting to membrane, translocation, exocrine pancreas development, granulocyte differentiation, neutrophil chemotaxis, protein targeting to ER; MF: 7S RNA binding, GDP binding, GTP binding, GTPase activity, RNA binding, endoplasmic reticulum signal peptide binding, hydrolase activity, nucleotide binding, protein binding, ribonucleoprotein complex binding; CC: cytoplasm, cytosol, endoplasmic reticulum, nuclear speck, nucleolus, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Homo sapiens (human), SRP-dependent cotranslational protein targeting to membrane, Translation, VEGFA-VEGFR2 Signaling Pathway, mRNA Processing
UniProt: P61011
Entrez ID: 6729
|
Does Knockout of MIR8087 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
MIR8087
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: MIR8087 (microRNA 8087)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465881
|
Does Activation of FNDC11 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
FNDC11
|
response to virus
|
Hepatoma Cell Line
|
Gene: FNDC11 (fibronectin type III domain containing 11)
Type: protein-coding
Summary: fibronectin type III domain containing 11
Gene Ontology:
Pathways:
UniProt: Q9BVV2
Entrez ID: 79025
|
Does Knockout of TRIM42 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
TRIM42
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: TRIM42 (tripartite motif containing 42)
Type: protein-coding
Summary: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: metal ion binding, protein binding, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: Q8IWZ5
Entrez ID: 287015
|
Does Knockout of ATP6V1B2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
ATP6V1B2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ATP6V1B2 (ATPase H+ transporting V1 subunit B2)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ATP metabolic process, monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification, vacuolar acidification; MF: ATP binding, nucleotide binding, protein binding, proton transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, extrinsic component of synaptic vesicle membrane, lysosomal membrane, melanosome, membrane, microvillus, plasma membrane, proton-transporting V-type ATPase, V1 domain, ruffle, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, mTOR signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: P21281
Entrez ID: 526
|
Does Knockout of ZNHIT2 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
ZNHIT2
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: ZNHIT2 (zinc finger HIT-type containing 2)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: Q9UHR6
Entrez ID: 741
|
Does Knockout of DOK1 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
DOK1
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: DOK1 (docking protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: Ras protein signal transduction, cell surface receptor protein tyrosine kinase signaling pathway, cell surface receptor signaling pathway, intracellular signal transduction, macrophage colony-stimulating factor signaling pathway, signal transduction; CC: cytoplasm, cytosol, nucleus, perinuclear region of cytoplasm
Pathways: Axon guidance, BCR, BCR signaling pathway, Developmental Biology, EGFR1, Fc-epsilon receptor I signaling in mast cells, Ghrelin, IL1, IL3, Insulin Pathway, Kit receptor signaling pathway, KitReceptor, Nervous system development, PDGFR-beta signaling pathway, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, RET signaling, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling events mediated by PTP1B, Signaling events mediated by Stem cell factor receptor (c-Kit), Signaling events regulated by Ret tyrosine kinase, TCR, TNFalpha, VEGFA-VEGFR2 Signaling Pathway
UniProt: Q99704
Entrez ID: 1796
|
Does Knockout of DPH6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
DPH6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: DPH6 (diphthamine biosynthesis 6)
Type: protein-coding
Summary: Enables diphthine-ammonia ligase activity. Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein histidyl modification to diphthamide; MF: ATP binding, diphthine-ammonia ligase activity, ligase activity, nucleotide binding
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Synthesis of diphthamide-EEF2, diphthamide biosynthesis
UniProt: Q7L8W6
Entrez ID: 89978
|
Does Knockout of CILP2 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
CILP2
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: CILP2 (cartilage intermediate layer protein 2)
Type: protein-coding
Summary: Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: alkaline phosphatase activity, dinucleotide phosphatase activity; CC: extracellular exosome, extracellular region, extracellular space
Pathways:
UniProt: Q8IUL8
Entrez ID: 148113
|
Does Knockout of NPHS1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
NPHS1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: NPHS1 (NPHS1 adhesion molecule, nephrin)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: JNK cascade, MAPK cascade, cell adhesion, cell-cell adhesion, gene expression, glomerular basement membrane development, muscle organ development, myoblast fusion, podocyte development, positive regulation of actin filament polymerization, protein localization to synapse, skeletal muscle tissue development, slit diaphragm assembly; MF: cell adhesion molecule binding, myosin binding, protein binding; CC: cell periphery, cell projection, cell-cell junction, extracellular exosome, focal adhesion, membrane, plasma membrane, slit diaphragm
Pathways: Genes controlling nephrogenesis, Nephrin/Neph1 signaling in the kidney podocyte, Nephrotic syndrome, Primary focal segmental glomerulosclerosis (FSGS)
UniProt: O60500
Entrez ID: 4868
|
Does Knockout of PDCD2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
PDCD2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: PDCD2 (programmed cell death 2)
Type: protein-coding
Summary: This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: apoptotic process, positive regulation of apoptotic process, positive regulation of hematopoietic stem cell proliferation, programmed cell death, regulation of hematopoietic progenitor cell differentiation; MF: DNA binding, enzyme binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, extracellular exosome, nucleus
Pathways: TNFalpha
UniProt: Q16342
Entrez ID: 5134
|
Does Knockout of CLEC1A in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
CLEC1A
|
response to virus
|
Hepatoma Cell Line
|
Gene: CLEC1A (C-type lectin domain family 1 member A)
Type: protein-coding
Summary: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: cell surface receptor signaling pathway, signal transduction; MF: carbohydrate binding, protein binding, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8NC01
Entrez ID: 51267
|
Does Knockout of POLR1B in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
POLR1B
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: POLR1B (RNA polymerase I subunit B)
Type: protein-coding
Summary: Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: DNA-templated transcription, embryo implantation, neural crest formation, nucleologenesis, rRNA transcription; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, DNA/RNA hybrid binding, metal ion binding, nucleotidyltransferase activity, protein binding, ribonucleoside binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, chromosome, cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Positive epigenetic regulation of rRNA expression, Pyrimidine metabolism, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Homo sapiens (human), TNFalpha, tumor suppressor arf inhibits ribosomal biogenesis
UniProt: Q9H9Y6
Entrez ID: 84172
|
Does Knockout of CAPN15 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
CAPN15
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: CAPN15 (calpain 15)
Type: protein-coding
Summary: This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: proteolysis; MF: calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, protein binding, zinc ion binding
Pathways: Degradation of the extracellular matrix, Extracellular matrix organization
UniProt: O75808
Entrez ID: 6650
|
Does Knockout of MYBPHL in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
MYBPHL
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: MYBPHL (myosin binding protein H like)
Type: protein-coding
Summary: This gene encodes a protein with two immunoglobulin superfamily domains and a fibronectin 3 domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012].
Gene Ontology: BP: biological_process, in utero embryonic development; MF: molecular_function, protein binding; CC: cytoplasm, myofilament, sarcomere
Pathways:
UniProt: A2RUH7
Entrez ID: 343263
|
Does Knockout of EEF1G in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
EEF1G
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: EEF1G (eukaryotic translation elongation factor 1 gamma)
Type: protein-coding
Summary: This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: response to virus, translation, translational elongation; MF: cadherin binding, protein binding, translation elongation factor activity; CC: cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, membrane, nucleus
Pathways: Legionellosis - Homo sapiens (human), Translation Factors
UniProt: P26641
Entrez ID: 1937
|
Does Knockout of GALNT5 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
GALNT5
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: GALNT5 (polypeptide N-acetylgalactosaminyltransferase 5)
Type: protein-coding
Summary: The protein encoded by this gene is a membrane-bound polypeptide N-acetylgalactosaminyltransferase that is found in the Golgi. The encoded protein catalyzes the first step in the mucin-type O-glycosylation of Golgi proteins, transfering an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: glycosaminoglycan biosynthetic process, protein O-linked glycosylation, protein O-linked glycosylation via N-acetyl-galactosamine, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism of proteins, Mucin type O-glycan biosynthesis - Homo sapiens (human), O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Homo sapiens (human), Post-translational protein modification, mucin core 1 and core 2 <i>O</i>-glycosylation
UniProt: Q7Z7M9
Entrez ID: 11227
|
Does Knockout of GNG7 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
GNG7
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: GNG7 (G protein subunit gamma 7)
Type: protein-coding
Summary: Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of adenylate cyclase activity. Predicted to act upstream of or within behavioral fear response; locomotory behavior; and receptor guanylyl cyclase signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, behavioral fear response, locomotory behavior, receptor guanylyl cyclase signaling pathway, regulation of G protein-coupled receptor signaling pathway, signal transduction; MF: G-protein beta-subunit binding, protein binding; CC: extracellular exosome, heterotrimeric G-protein complex, membrane, plasma membrane, synapse
Pathways: ADORA2B mediated anti-inflammatory cytokines production, ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of G protein gated Potassium channels, Activation of GABAB receptors, Activation of kainate receptors upon glutamate binding, Adrenaline,noradrenaline inhibits insulin secretion, Alcoholism - Homo sapiens (human), Anti-inflammatory response favouring Leishmania parasite infection, Apelin signaling pathway - Homo sapiens (human), Aquaporin-mediated transport, Beta-catenin independent WNT signaling, Ca2+ pathway, Calcium Regulation in the Cardiac Cell, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chaperonin-mediated protein folding, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Class B/2 (Secretin family receptors), Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Disease, Dopaminergic synapse - Homo sapiens (human), ESR-mediated signaling, Extra-nuclear estrogen signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, G Protein Signaling Pathways, G alpha (12/13) signalling events, G alpha (i) signalling events, G alpha (q) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G beta:gamma signalling through BTK, G beta:gamma signalling through CDC42, G beta:gamma signalling through PI3Kgamma, G beta:gamma signalling through PLC beta, G protein gated Potassium channels, G-protein activation, G-protein beta:gamma signalling, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Homo sapiens (human), GPCR downstream signalling, GPCR ligand binding, GPER1 signaling, Glucagon signaling in metabolic regulation, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Glutamatergic synapse - Homo sapiens (human), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Infectious disease, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Integration of energy metabolism, Inwardly rectifying K+ channels, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Leishmania infection, Leishmania parasite growth and survival, Metabolism, Metabolism of proteins, Morphine addiction - Homo sapiens (human), Myometrial relaxation and contraction pathways, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Olfactory transduction - Homo sapiens (human), Opioid Signalling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parasitic Infection Pathways, Pathways in cancer - Homo sapiens (human), Platelet activation, signaling and aggregation, Platelet homeostasis, Potassium Channels, Presynaptic function of Kainate receptors, Prostacyclin signalling through prostacyclin receptor, Protein folding, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of insulin secretion, Relaxin signaling pathway - Homo sapiens (human), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by WNT, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, Transmission across Chemical Synapses, Transport of small molecules, Vasopressin regulates renal water homeostasis via Aquaporins
UniProt: O60262
Entrez ID: 2788
|
Does Knockout of CBLB in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
CBLB
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: CBLB (Cbl proto-oncogene B)
Type: protein-coding
Summary: This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017].
Gene Ontology: BP: CD4-positive, alpha-beta T cell proliferation, NLS-bearing protein import into nucleus, T cell activation, T cell anergy, T cell receptor signaling pathway, cell surface receptor signaling pathway, immune response, intracellular signal transduction, negative regulation of CD4-positive, alpha-beta T cell proliferation, negative regulation of T cell receptor signaling pathway, negative regulation of epidermal growth factor receptor signaling pathway, positive regulation of T cell anergy, positive regulation of protein catabolic process, positive regulation of protein ubiquitination, protein catabolic process, protein ubiquitination, regulation of cell adhesion, regulation of platelet-derived growth factor receptor-alpha signaling pathway, regulation of postsynaptic neurotransmitter receptor internalization, regulation of signaling, regulation protein catabolic process at postsynapse, signal transduction; MF: calcium ion binding, metal ion binding, phosphotyrosine residue binding, protein binding, receptor tyrosine kinase binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, glutamatergic synapse, membrane raft, nucleoplasm, plasma membrane, postsynapse
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, BCR, C-type lectin receptor signaling pathway - Homo sapiens (human), CD40/CD40L signaling, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, EGF-EGFR signaling pathway, EGFR1, Endocytosis - Homo sapiens (human), ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), Fc-epsilon receptor I signaling in mast cells, Genotoxicity pathway, IL-7, Insulin Signaling, Insulin signaling pathway - Homo sapiens (human), Internalization of ErbB1, KitReceptor, Measles - Homo sapiens (human), Modulators of TCR signaling and T cell activation, T cell receptor signaling pathway - Homo sapiens (human), T-cell receptor (TCR) signaling pathway, TCR, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q13191
Entrez ID: 868
|
Does Knockout of CAND2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
CAND2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: CAND2 (cullin associated and neddylation dissociated 2 (putative))
Type: protein-coding
Summary: Predicted to enable TBP-class protein binding activity. Predicted to be involved in SCF complex assembly; positive regulation of transcription, DNA-templated; and protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: SCF complex assembly, positive regulation of DNA-templated transcription, protein ubiquitination; MF: TBP-class protein binding, protein binding; CC: cytosol, nucleus
Pathways:
UniProt: O75155
Entrez ID: 23066
|
Does Knockout of CRISPLD1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
CRISPLD1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: CRISPLD1 (cysteine rich secretory protein LCCL domain containing 1)
Type: protein-coding
Summary: Involved in face morphogenesis. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: face morphogenesis, hematopoietic stem cell homeostasis; CC: extracellular exosome, extracellular region, extracellular space
Pathways:
UniProt: Q9H336
Entrez ID: 83690
|
Does Knockout of DHX33 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
DHX33
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: DHX33 (DEAH-box helicase 33)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: positive regulation of MAPK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of transcription by RNA polymerase I, positive regulation of type I interferon production, translational initiation; MF: ATP binding, ATP hydrolysis activity, DNA-binding transcription factor binding, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding, rDNA binding, ribosomal large subunit binding; CC: NLRP3 inflammasome complex, canonical inflammasome complex, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: NOD-like receptor signaling pathway - Homo sapiens (human)
UniProt: Q9H6R0
Entrez ID: 56919
|
Does Knockout of SNUPN in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
SNUPN
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SNUPN (snurportin 1)
Type: protein-coding
Summary: The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA import into nucleus, cytoskeleton organization, protein complex oligomerization, protein import into nucleus, protein tetramerization, snRNA import into nucleus; MF: RNA binding, RNA cap binding, nuclear import signal receptor activity, protein binding; CC: NLS-dependent protein nuclear import complex, cytoplasm, cytosol, nuclear pore, nucleoplasm, nucleus, plasma membrane
Pathways: Metabolism of RNA, Metabolism of non-coding RNA, RNA transport - Homo sapiens (human), snRNP Assembly
UniProt: O95149
Entrez ID: 10073
|
Does Knockout of NAF1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
NAF1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: NAF1 (nuclear assembly factor 1 ribonucleoprotein)
Type: protein-coding
Summary: Enables identical protein binding activity and telomerase RNA binding activity. Involved in regulation of nucleobase-containing compound metabolic process; ribosome biogenesis; and telomerase holoenzyme complex assembly. Located in nucleoplasm. Part of sno(s)RNA-containing ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA stabilization, box H/ACA snoRNP assembly, positive regulation of telomere maintenance via telomerase, positive regulation of telomere maintenance via telomere lengthening, protein-RNA complex assembly, pseudouridine synthesis, rRNA processing, ribosome biogenesis, snoRNA guided rRNA pseudouridine synthesis, telomerase RNA localization to Cajal body, telomerase RNA stabilization, telomerase holoenzyme complex assembly; MF: RNA binding, identical protein binding, protein binding, telomerase RNA binding; CC: cytoplasm, nucleoplasm, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex
Pathways:
UniProt: Q96HR8
Entrez ID: 92345
|
Does Knockout of PAFAH1B1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
PAFAH1B1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1)
Type: protein-coding
Summary: This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided by RefSeq, Apr 2009].
Gene Ontology: BP: JNK cascade, acrosome assembly, actin cytoskeleton organization, adult locomotory behavior, ameboidal-type cell migration, auditory receptor cell development, brain morphogenesis, cell differentiation, cell division, cell migration, cerebral cortex development, cerebral cortex neuron differentiation, chemical synaptic transmission, cochlea development, corpus callosum morphogenesis, cortical microtubule organization, establishment of centrosome localization, establishment of localization in cell, establishment of mitotic spindle orientation, establishment of organelle localization, establishment of planar polarity of embryonic epithelium, forebrain development, germ cell development, hippocampus development, interneuron migration, layer formation in cerebral cortex, learning or memory, lipid catabolic process, lipid metabolic process, maintenance of centrosome location, microtubule cytoskeleton organization, microtubule cytoskeleton organization involved in establishment of planar polarity, microtubule organizing center organization, microtubule sliding, microtubule-based process, modulation of chemical synaptic transmission, myeloid leukocyte migration, negative regulation of JNK cascade, negative regulation of neuron projection development, nervous system development, neuroblast proliferation, neuromuscular process controlling balance, neuron migration, nuclear membrane disassembly, nuclear migration, osteoclast development, platelet activating factor metabolic process, positive regulation of axon extension, positive regulation of cellular component organization, positive regulation of cytokine-mediated signaling pathway, positive regulation of dendritic spine morphogenesis, positive regulation of embryonic development, positive regulation of mitotic cell cycle, protein secretion, radial glia-guided pyramidal neuron migration, reelin-mediated signaling pathway, regulation of microtubule cytoskeleton organization, regulation of postsynapse organization, retrograde axonal transport, stem cell division, transmission of nerve impulse, vesicle transport along microtubule; MF: dynactin binding, dynein complex binding, dynein intermediate chain binding, heparin binding, identical protein binding, microtubule binding, microtubule plus-end binding, phospholipase binding, phosphoprotein binding, protein binding, protein heterodimerization activity, protein-containing complex binding; CC: 1-alkyl-2-acetylglycerophosphocholine esterase complex, Schaffer collateral - CA1 synapse, astral microtubule, axon, axon cytoplasm, cell cortex, cell leading edge, central region of growth cone, centrosome, cytoplasm, cytoplasmic microtubule, cytoskeleton, cytosol, extracellular exosome, glutamatergic synapse, growth cone, kinesin complex, kinetochore, membrane, microtubule, microtubule associated complex, microtubule cytoskeleton, motile cilium, neuron projection, neuronal cell body, nuclear envelope, nuclear membrane, nucleus, perinuclear region of cytoplasm, spindle, stereocilium, vesicle
Pathways: AURKA Activation by TPX2, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, COPI-independent Golgi-to-ER retrograde traffic, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Centrosome maturation, Ciliary landscape, Cilium Assembly, EML4 and NUDC in mitotic spindle formation, Ether lipid metabolism - Homo sapiens (human), G2/M Transition, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Lissencephaly gene (LIS1) in neuronal migration and development, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Membrane Trafficking, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Organelle biogenesis and maintenance, RHO GTPase Effectors, RHO GTPases Activate Formins, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Reelin signaling pathway, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport, Wnt signaling pathway and pluripotency, lissencephaly gene (lis1) in neuronal migration and development
UniProt: P43034
Entrez ID: 5048
|
Does Knockout of UBE2S in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
UBE2S
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: UBE2S (ubiquitin conjugating enzyme E2 S)
Type: protein-coding
Summary: This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, anaphase-promoting complex-dependent catabolic process, cell division, exit from mitosis, free ubiquitin chain polymerization, positive regulation of ubiquitin protein ligase activity, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K29-linked ubiquitination, protein K6-linked ubiquitination, protein K63-linked ubiquitination, protein modification by small protein conjugation, protein modification process, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, anaphase-promoting complex binding, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-like protein transferase activity, ubiquitin-protein transferase activity; CC: anaphase-promoting complex, cytosol, nucleoplasm, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Phosphorylation of the APC/C, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q16763
Entrez ID: 27338
|
Does Knockout of MRPL35 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
MRPL35
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: MRPL35 (mitochondrial ribosomal protein L35)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9NZE8
Entrez ID: 51318
|
Does Knockout of NIP7 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
NIP7
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: NIP7 (nucleolar pre-rRNA processing protein NIP7)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome assembly, ribosome biogenesis; MF: RNA binding, protein binding; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y221
Entrez ID: 51388
|
Does Knockout of RPL29 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
RPL29
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: RPL29 (ribosomal protein L29)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, embryo implantation, translation; MF: RNA binding, cadherin binding, heparin binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P47914
Entrez ID: 6159
|
Does Knockout of VPS45 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
VPS45
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: VPS45 (vacuolar protein sorting 45 homolog)
Type: protein-coding
Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: intracellular protein transport, protein transport, vesicle-mediated transport; CC: Golgi apparatus, Golgi membrane, cytoplasmic vesicle, endomembrane system, endosome, endosome membrane, membrane, synaptic vesicle
Pathways: Disease, Endocytosis - Homo sapiens (human), Factors involved in megakaryocyte development and platelet production, Hemostasis, Infectious disease, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates autophagy, SARS-CoV-2-host interactions, Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q9NRW7
Entrez ID: 11311
|
Does Knockout of STEAP3 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
STEAP3
|
cell proliferation
|
Cancer Cell Line
|
Gene: STEAP3 (STEAP3 metalloreductase)
Type: protein-coding
Summary: This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: apoptotic process, copper ion import, iron ion transport, monoatomic ion transport, protein secretion; MF: FAD binding, cupric reductase (NADH) activity, ferric-chelate reductase (NADPH) activity, heme binding, identical protein binding, metal ion binding, oxidoreductase activity, protein binding; CC: cytoplasm, endosome, endosome membrane, membrane, multivesicular body, plasma membrane
Pathways: CDC42 GTPase cycle, Copper homeostasis, Direct p53 effectors, Ferroptosis, Ferroptosis - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, Iron metabolism in placenta, Iron uptake and transport, RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, RNA Polymerase II Transcription, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53, Transferrin endocytosis and recycling, Transport of small molecules, p53 signaling pathway - Homo sapiens (human)
UniProt: Q658P3
Entrez ID: 55240
|
Does Knockout of FBP2 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
FBP2
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: FBP2 (fructose-bisphosphatase 2)
Type: protein-coding
Summary: This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate metabolic process, fructose 1,6-bisphosphate metabolic process, fructose 6-phosphate metabolic process, fructose metabolic process, gluconeogenesis; MF: catalytic activity, fructose 1,6-bisphosphate 1-phosphatase activity, hydrolase activity, identical protein binding, metal ion binding, phosphatase activity, phosphoric ester hydrolase activity, protein binding; CC: Z disc, anchoring junction, cytoplasm, cytosol, extracellular exosome, nucleus, plasma membrane
Pathways: AMPK signaling pathway - Homo sapiens (human), Fructose and mannose metabolism - Homo sapiens (human), Glucagon signaling pathway - Homo sapiens (human), Gluconeogenesis, Glucose metabolism, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, Insulin signaling pathway - Homo sapiens (human), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway - Homo sapiens (human), gluconeogenesis
UniProt: O00757
Entrez ID: 8789
|
Does Activation of MITD1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
MITD1
|
response to virus
|
Hepatoma Cell Line
|
Gene: MITD1 (microtubule interacting and trafficking domain containing 1)
Type: protein-coding
Summary: Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cell division, midbody abscission, mitotic cytokinesis, multivesicular body sorting pathway, negative regulation of protein binding, viral budding via host ESCRT complex; MF: identical protein binding, phosphatidylinositol binding, protein binding, protein domain specific binding; CC: endosome, extracellular exosome, late endosome membrane, membrane, midbody
Pathways:
UniProt: Q8WV92
Entrez ID: 129531
|
Does Knockout of NDUFV2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
NDUFV2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2)
Type: protein-coding
Summary: The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: aerobic respiration, cardiac muscle tissue development, mitochondrial electron transport, NADH to ubiquinone, nervous system development, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: 2 iron, 2 sulfur cluster binding, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, electron transfer activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human)
UniProt: P19404
Entrez ID: 4729
|
Does Knockout of DDX56 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
DDX56
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: DDX56 (DEAD-box helicase 56)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: cytoplasmic pattern recognition receptor signaling pathway, defense response to virus, host-mediated perturbation of viral RNA genome replication, negative regulation of type I interferon production, positive regulation of neuron projection development, protein import into nucleus, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA stem-loop binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding, protein sequestering activity; CC: cytosol, membrane, nucleolus, nucleus
Pathways:
UniProt: Q9NY93
Entrez ID: 54606
|
Does Knockout of AGL in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
AGL
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: AGL (amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase)
Type: protein-coding
Summary: This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate metabolic process, glycogen biosynthetic process, glycogen catabolic process, glycogen metabolic process, response to glucocorticoid, response to hormone, response to nutrient; MF: 4-alpha-glucanotransferase activity, amylo-alpha-1,6-glucosidase activity, carbohydrate binding, catalytic activity, glycosyltransferase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, polysaccharide binding, polyubiquitin modification-dependent protein binding, protein binding, transferase activity; CC: cytoplasm, cytosol, extracellular region, ficolin-1-rich granule lumen, inclusion body, isoamylase complex, nucleus, sarcoplasmic reticulum, secretory granule lumen
Pathways: Glycogen Synthesis and Degradation, Glycogen breakdown (glycogenolysis), Glycogen metabolism, Glycogen synthetase deficiency, Glycogenosis, Type III. Cori disease, Debrancher glycogenosis, Glycogenosis, Type IV. Amylopectinosis, Anderson disease, Glycogenosis, Type VI. Hers disease, Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Mucopolysaccharidosis VI. Sly syndrome, Neutrophil degranulation, Starch and Sucrose Metabolism, Starch and sucrose metabolism - Homo sapiens (human), Sucrase-isomaltase deficiency, glycogenolysis
UniProt: P35573
Entrez ID: 178
|
Does Knockout of SYT14 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
SYT14
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: SYT14 (synaptotagmin 14)
Type: protein-coding
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011].
Gene Ontology: MF: identical protein binding, phospholipid binding
Pathways:
UniProt: Q8NB59
Entrez ID: 255928
|
Does Knockout of CPSF4 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
CPSF4
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: CPSF4 (cleavage and polyadenylation specific factor 4)
Type: protein-coding
Summary: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: RNA binding, metal ion binding, nucleic acid binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Disease, Gene expression (Transcription), Infectious disease, Influenza A - Homo sapiens (human), Influenza Infection, Inhibition of Host mRNA Processing and RNA Silencing, Metabolism of RNA, NS1 Mediated Effects on Host Pathways, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Viral Infection Pathways, mRNA 3'-end processing, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human), polyadenylation of mrna, tRNA processing, tRNA processing in the nucleus
UniProt: O95639
Entrez ID: 10898
|
Does Knockout of DDX18 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
DDX18
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: DDX18 (DEAD-box helicase 18)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to estradiol stimulus, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: chromosome, membrane, nucleolus, nucleus
Pathways: Validated targets of C-MYC transcriptional activation
UniProt: Q9NVP1
Entrez ID: 8886
|
Does Knockout of SMC3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
SMC3
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: SMC3 (structural maintenance of chromosomes 3)
Type: protein-coding
Summary: This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, cell division, chromosome organization, establishment of meiotic sister chromatid cohesion, establishment of mitotic sister chromatid cohesion, meiotic cell cycle, mitotic cell cycle, mitotic sister chromatid cohesion, mitotic spindle assembly, regulation of DNA replication, sister chromatid cohesion, stem cell population maintenance; MF: ATP binding, ATP hydrolysis activity, beta-tubulin binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, dynein complex binding, mediator complex binding, microtubule motor activity, nucleotide binding, protein binding, protein heterodimerization activity; CC: chromatin, chromosome, chromosome, centromeric region, cohesin complex, cytosol, lateral element, meiotic cohesin complex, mitotic cohesin complex, mitotic spindle pole, nuclear lumen, nuclear matrix, nucleoplasm, nucleus
Pathways: ATM pathway, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cohesin Loading onto Chromatin, ESR-mediated signaling, Establishment of Sister Chromatid Cohesion, Estrogen-dependent gene expression, M Phase, MECP2 and Associated Rett Syndrome, Meiosis, Meiotic synapsis, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Telophase/Cytokinesis, Oocyte meiosis - Homo sapiens (human), Post-translational protein modification, Prion disease pathway, Regulation of sister chromatid separation at the metaphase-anaphase transition, Reproduction, Resolution of Sister Chromatid Cohesion, Retinoblastoma gene in cancer, S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q9UQE7
Entrez ID: 9126
|
Does Knockout of NRF1 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
NRF1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: NRF1 (nuclear respiratory factor 1)
Type: protein-coding
Summary: This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1. [provided by RefSeq, May 2014].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, protein homodimerization activity; CC: cytosol, extracellular exosome, nucleoplasm, nucleus
Pathways: Apelin signaling pathway - Homo sapiens (human), Energy Metabolism, Huntington disease - Homo sapiens (human), Mitochondrial Gene Expression, Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway
UniProt: Q16656
Entrez ID: 4899
|
Does Knockout of CLTCL1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
CLTCL1
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: CLTCL1 (clathrin heavy chain like 1)
Type: protein-coding
Summary: This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: anatomical structure morphogenesis, intracellular protein transport, mitotic cell cycle, positive regulation of D-glucose import, receptor-mediated endocytosis, retrograde transport, endosome to Golgi, vesicle-mediated transport; MF: clathrin light chain binding, protein binding, structural molecule activity; CC: clathrin coat of trans-Golgi network vesicle, clathrin complex, clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle, coated vesicle, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, early endosome, extracellular exosome, late endosome, membrane, plasma membrane, recycling endosome, sorting endosome, spindle, trans-Golgi network
Pathways: 22q11.2 copy number variation syndrome, Axon guidance, Bacterial invasion of epithelial cells - Homo sapiens (human), Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, Ebola Virus Pathway on Host, Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), Endocytosis - Homo sapiens (human), Formation of annular gap junctions, Fragile X Syndrome, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Huntington disease - Homo sapiens (human), Lysosome - Homo sapiens (human), Membrane Trafficking, Nervous system development, Synaptic Vesicle Pathway, Synaptic vesicle cycle - Homo sapiens (human), Vesicle-mediated transport
UniProt: P53675
Entrez ID: 8218
|
Does Knockout of DHX15 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
DHX15
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: DHX15 (DEAH-box helicase 15)
Type: protein-coding
Summary: The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, antiviral innate immune response, defense response to bacterium, defense response to virus, immune system process, innate immune response, mRNA processing, mRNA splicing, via spliceosome, positive regulation of canonical NF-kappaB signal transduction, response to alkaloid, response to toxic substance; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on RNA, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: U12-type spliceosomal complex, U2-type post-mRNA release spliceosomal complex, nuclear speck, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O43143
Entrez ID: 1665
|
Does Knockout of MGST1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
MGST1
|
cell proliferation
|
Cancer Cell Line
|
Gene: MGST1 (microsomal glutathione S-transferase 1)
Type: protein-coding
Summary: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: cellular oxidant detoxification, cellular response to lipid hydroperoxide, glutathione transport; MF: glutathione peroxidase activity, glutathione transferase activity, protein binding, transferase activity; CC: azurophil granule membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion, peroxisomal membrane, plasma membrane
Pathways: Aflatoxin activation and detoxification, Aryl Hydrocarbon Receptor Pathway, Biological oxidations, Chemical carcinogenesis - Homo sapiens (human), Drug metabolism - cytochrome P450 - Homo sapiens (human), Drug metabolism - other enzymes - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), Glutathione conjugation, Glutathione metabolism - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Immune System, Innate Immune System, Metabolism, Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human), Metapathway biotransformation Phase I and II, Neutrophil degranulation, Nuclear Receptors Meta-Pathway, Oxidative Stress, Pathways in cancer - Homo sapiens (human), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: P10620
Entrez ID: 4257
|
Does Knockout of FGF22 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
FGF22
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: FGF22 (fibroblast growth factor 22)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: cell differentiation, fibroblast growth factor receptor signaling pathway, neurogenesis, positive regulation of MAPK cascade, positive regulation of cell population proliferation, regulation of cell migration, regulation of synapse maturation, trans-synaptic signaling; MF: fibroblast growth factor receptor binding, growth factor activity; CC: GABA-ergic synapse, Golgi apparatus, cell surface, cytoplasm, extracellular region, extracellular space, extrinsic component of postsynaptic density membrane, glutamatergic synapse, nucleolus, postsynapse
Pathways: Activated point mutants of FGFR2, Breast cancer - Homo sapiens (human), Breast cancer pathway, Calcium signaling pathway - Homo sapiens (human), Constitutive Signaling by Aberrant PI3K in Cancer, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, ESC Pluripotency Pathways, FGFR1 ligand binding and activation, FGFR1b ligand binding and activation, FGFR2 ligand binding and activation, FGFR2 mutant receptor activation, FGFR2b ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Gastric cancer - Homo sapiens (human), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, Melanoma - Homo sapiens (human), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI3K Cascade, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Homo sapiens (human), Phospholipase C-mediated cascade: FGFR1, Phospholipase C-mediated cascade; FGFR2, RAF/MAP kinase cascade, Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR2 in disease, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: Q9HCT0
Entrez ID: 27006
|
Does Knockout of PUM1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
PUM1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: PUM1 (pumilio RNA binding family member 1)
Type: protein-coding
Summary: This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, adult locomotory behavior, cell differentiation, mRNA destabilization, miRNA processing, positive regulation of RIG-I signaling pathway, positive regulation of miRNA-mediated gene silencing, post-transcriptional gene silencing, post-transcriptional regulation of gene expression, regulation of cell cycle, regulation of chromosome segregation, regulation of mRNA stability, regulation of miRNA-mediated gene silencing, regulation of translation, spermatogenesis, stem cell differentiation; MF: RNA binding, mRNA 3'-UTR binding, miRNA binding, protein binding; CC: P-body, axon, cytoplasm, cytoplasmic stress granule, cytosol, nucleoplasm
Pathways: Golgi Associated Vesicle Biogenesis, Membrane Trafficking, Spinocerebellar ataxia - Homo sapiens (human), Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q14671
Entrez ID: 9698
|
Does Knockout of VPS16 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
VPS16
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: VPS16 (VPS16 core subunit of CORVET and HOPS complexes)
Type: protein-coding
Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: autophagosome maturation, autophagy, endosomal transport, endosomal vesicle fusion, endosome to lysosome transport, intracellular protein transport, protein transport, regulation of SNARE complex assembly, vacuole fusion, non-autophagic, vacuole organization; MF: actin binding, actin filament binding, protein binding; CC: CORVET complex, HOPS complex, autophagosome, axon, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, early endosome, endosome, endosome membrane, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, neuronal cell body, presynapse, recycling endosome, vesicle tethering complex
Pathways: Alpha4 beta1 integrin signaling events, Disease, EGFR1, Ebola Virus Pathway on Host, Infectious disease, Insulin Pathway, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates autophagy, SARS-CoV-2-host interactions, Salmonella infection - Homo sapiens (human), TCR, Viral Infection Pathways
UniProt: Q9H269
Entrez ID: 64601
|
Does Knockout of PLK4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
PLK4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: PLK4 (polo like kinase 4)
Type: protein-coding
Summary: This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: centriole replication, cilium assembly, de novo centriole assembly involved in multi-ciliated epithelial cell differentiation, positive regulation of centriole replication, protein phosphorylation, regulation of cell cycle process, trophoblast giant cell differentiation; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: XY body, centriole, centrosome, cleavage furrow, cytoplasm, cytoskeleton, cytosol, deuterosome, nucleolus, nucleus, procentriole, procentriole replication complex
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Ciliopathies, Cilium Assembly, FoxO signaling pathway - Homo sapiens (human), G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Retinoblastoma gene in cancer
UniProt: O00444
Entrez ID: 10733
|
Does Knockout of EAF1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
EAF1
|
cell proliferation
|
Cancer Cell Line
|
Gene: EAF1 (ELL associated factor 1)
Type: protein-coding
Summary: Enables transcription elongation regulator activity. Involved in regulation of transcription elongation from RNA polymerase II promoter. Located in intercellular bridge and nuclear body. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of transcription elongation by RNA polymerase II, transcription elongation by RNA polymerase II; MF: protein binding, transcription elongation factor activity; CC: Cajal body, intercellular bridge, nuclear body, nuclear speck, nucleoplasm, nucleus, super elongation complex, transcription elongation factor complex
Pathways: Formation of RNA Pol II elongation complex , Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q96JC9
Entrez ID: 85403
|
Does Knockout of ING4 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
ING4
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ING4 (inhibitor of growth family member 4)
Type: protein-coding
Summary: This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication-dependent chromatin disassembly, apoptotic process, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of growth, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, protein acetylation, regulation of DNA biosynthetic process, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell cycle G2/M phase transition, regulation of cell growth; MF: histone H3K14 acetyltransferase activity, histone H3K4me3 reader activity, histone H4K12 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, metal ion binding, protein binding, transcription coactivator activity, zinc ion binding; CC: cytosol, histone acetyltransferase complex, intermediate filament cytoskeleton, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9UNL4
Entrez ID: 51147
|
Does Knockout of OFD1 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
OFD1
|
response to virus
|
Lung Cancer Cell Line
|
Gene: OFD1 (OFD1 centriole and centriolar satellite protein)
Type: protein-coding
Summary: This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, however, unlike the human gene it is not subject to X inactivation. Mutations in this gene are associated with oral-facial-digital syndrome type I and Simpson-Golabi-Behmel syndrome type 2. Many pseudogenes have been identified; a single pseudogene is found on chromosome 5 while as many as fifteen have been found on the Y chromosome. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: axoneme assembly, cell projection organization, centriole replication, cilium assembly, embryonic body morphogenesis, epithelial cilium movement involved in determination of left/right asymmetry, mitotic cell cycle, mitotic spindle assembly, negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; MF: alpha-tubulin binding, gamma-tubulin binding, identical protein binding, molecular adaptor activity, protein binding; CC: cell projection, centriolar satellite, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, extracellular region, membrane, motile cilium, nucleus
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Ciliopathies, Cilium Assembly, G2/M Transition, Genes related to primary cilium development (based on CRISPR), Hedgehog 'off' state, Joubert Syndrome, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Signal Transduction, Signaling by Hedgehog
UniProt: O75665
Entrez ID: 8481
|
Does Knockout of PTBP3 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
PTBP3
|
cell proliferation
|
Cancer Cell Line
|
Gene: PTBP3 (polypyrimidine tract binding protein 3)
Type: protein-coding
Summary: The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: RNA splicing, anatomical structure morphogenesis, cell differentiation, erythrocyte maturation, mRNA processing, negative regulation of RNA splicing, regulation of RNA splicing, regulation of cell differentiation; MF: RNA binding, mRNA binding, nucleic acid binding; CC: nucleus
Pathways:
UniProt: O95758
Entrez ID: 9991
|
Does Knockout of SNRPG in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
SNRPG
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SNRPG (small nuclear ribonucleoprotein polypeptide G)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: 7-methylguanosine cap hypermethylation, RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, spliceosomal complex assembly, spliceosomal snRNP assembly; MF: RNA binding, protein binding; CC: P granule, SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type prespliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, precatalytic spliceosome, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Disease, Gene expression (Transcription), Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Homo sapiens (human), Viral Infection Pathways, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62308
Entrez ID: 6637
|
Does Knockout of TP53BP2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
TP53BP2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TP53BP2 (tumor protein p53 binding protein 2)
Type: protein-coding
Summary: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of cell cycle, positive regulation of execution phase of apoptosis, regulation of apoptotic process, signal transduction; MF: NF-kappaB binding, SH3 domain binding, identical protein binding, p53 binding, protein binding, protein homodimerization activity; CC: cell junction, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Direct p53 effectors, Hippo signaling pathway - Homo sapiens (human)
UniProt: Q13625
Entrez ID: 7159
|
Does Knockout of CADPS in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
CADPS
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: CADPS (calcium dependent secretion activator)
Type: protein-coding
Summary: This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: dense core granule exocytosis, exocytosis, positive regulation of exocytosis, protein transport, synaptic vesicle exocytosis; MF: lipid binding, metal ion binding, protein binding, protein kinase binding; CC: cytoplasmic vesicle, cytosol, glutamatergic synapse, membrane, neuronal dense core vesicle membrane, presynapse, synapse
Pathways:
UniProt: Q9ULU8
Entrez ID: 8618
|
Does Knockout of PGPEP1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
PGPEP1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PGPEP1 (pyroglutamyl-peptidase I)
Type: protein-coding
Summary: The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: protein catabolic process, proteolysis; MF: cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding, pyroglutamyl-peptidase activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q9NXJ5
Entrez ID: 54858
|
Does Knockout of NUDCD1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
NUDCD1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: NUDCD1 (NudC domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in immune system process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q96RS6
Entrez ID: 84955
|
Does Knockout of HDHD5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
HDHD5
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: HDHD5 (haloacid dehalogenase like hydrolase domain containing 5)
Type: protein-coding
Summary: Predicted to be involved in glycerophospholipid biosynthetic process. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: mitochondrion
Pathways:
UniProt: Q9BXW7
Entrez ID: 27440
|
Does Knockout of AMIGO1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
AMIGO1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: AMIGO1 (adhesion molecule with Ig like domain 1)
Type: protein-coding
Summary: Predicted to enable potassium channel regulator activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in dendrite and neuronal cell body membrane. Predicted to be integral component of membrane. Predicted to colocalize with voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: axonal fasciculation, axonogenesis, brain development, cell adhesion, cell differentiation, cellular response to L-glutamate, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, myelination, nervous system development, neuron projection fasciculation, positive regulation of axonogenesis, positive regulation of cellular component organization, positive regulation of nervous system development, positive regulation of neuron projection development, positive regulation of potassium ion transmembrane transport, positive regulation of synapse assembly; MF: potassium channel regulator activity, protein binding; CC: axon, cell projection, dendrite, membrane, neuron projection, neuronal cell body, neuronal cell body membrane, pericellular basket, perikaryon, plasma membrane, voltage-gated potassium channel complex
Pathways:
UniProt: Q86WK6
Entrez ID: 57463
|
Does Knockout of DMKN in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
DMKN
|
cell proliferation
|
Bladder Carcinoma
|
Gene: DMKN (dermokine)
Type: protein-coding
Summary: This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: cornified envelope assembly; CC: extracellular region, extracellular space
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
UniProt: Q6E0U4
Entrez ID: 93099
|
Does Knockout of PAK6 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
PAK6
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: PAK6 (p21 (RAC1) activated kinase 6)
Type: protein-coding
Summary: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: apoptotic process, cellular response to starvation, cytoskeleton organization, intracellular signal transduction, learning, locomotory behavior, memory, neuron projection arborization, neuron projection extension, regulation of DNA-templated transcription, regulation of MAPK cascade; MF: ATP binding, cadherin binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell junction, cytoplasm, cytosol, fibrillar center, nucleoplasm, nucleus, postsynaptic density
Pathways: Activation of RAC1, Androgen receptor signaling pathway, AndrogenReceptor, Axon guidance, Axon guidance - Homo sapiens (human), CDC42 GTPase cycle, Developmental Biology, ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), Focal Adhesion, Focal adhesion - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Human immunodeficiency virus 1 infection - Homo sapiens (human), Integrin-mediated Cell Adhesion, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Nervous system development, Neural Crest Cell Migration during Development, Neural Crest Cell Migration in Cancer, Pancreatic adenocarcinoma pathway, RAC1 GTPase cycle, RHO GTPase cycle, RHOD GTPase cycle, RHOH GTPase cycle, RHOV GTPase cycle, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), Signal Transduction, Signaling by ROBO receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, T cell receptor signaling pathway - Homo sapiens (human), agrin in postsynaptic differentiation
UniProt: Q9NQU5
Entrez ID: 56924
|
Does Knockout of WFDC10B in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
WFDC10B
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: WFDC10B (WAP four-disulfide core domain 10B)
Type: protein-coding
Summary: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode distinct isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: antibacterial humoral response, innate immune response; MF: peptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8IUB3
Entrez ID: 280664
|
Does Knockout of PRAME in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
PRAME
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PRAME (PRAME nuclear receptor transcriptional regulator)
Type: protein-coding
Summary: This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: apoptotic process, cell differentiation, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, negative regulation of retinoic acid receptor signaling pathway, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination; MF: nuclear retinoic acid receptor binding, protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, Golgi apparatus, chromatin, chromosome, cytoplasm, membrane, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: P78395
Entrez ID: 23532
|
Does Knockout of RPRD1B in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
RPRD1B
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: RPRD1B (regulation of nuclear pre-mRNA domain containing 1B)
Type: protein-coding
Summary: Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in positive regulation of cell population proliferation; regulation of cell cycle process; and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA polymerase II promoter clearance, mRNA 3'-end processing, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, regulation of cell cycle process; MF: RNA polymerase II C-terminal domain binding, RNA polymerase II complex binding, identical protein binding, protein binding; CC: nucleoplasm, nucleus, transcription preinitiation complex
Pathways: Gene expression (Transcription), Modulators of TCR signaling and T cell activation, RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q9NQG5
Entrez ID: 58490
|
Does Knockout of AOX1 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
AOX1
|
response to virus
|
Lung Cancer Cell Line
|
Gene: AOX1 (aldehyde oxidase 1)
Type: protein-coding
Summary: Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: lipid metabolic process, xenobiotic metabolic process; MF: 2 iron, 2 sulfur cluster binding, FAD binding, NAD binding, aldehyde oxidase activity, flavin adenine dinucleotide binding, identical protein binding, iron ion binding, iron-sulfur cluster binding, metal ion binding, molybdopterin cofactor binding, oxidoreductase activity, protein homodimerization activity; CC: cytoplasm, cytosol, extracellular exosome, intercellular bridge, microtubule cytoskeleton, nuclear body
Pathways: 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency, 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency, 3-Methylcrotonyl Coa Carboxylase Deficiency Type I, 3-Methylglutaconic Aciduria Type I, 3-Methylglutaconic Aciduria Type III, 3-Methylglutaconic Aciduria Type IV, 3-hydroxyisobutyric acid dehydrogenase deficiency, 3-hydroxyisobutyric aciduria, Azathioprine Action Pathway, Beta-Ketothiolase Deficiency, Citalopram Action Pathway, Citalopram Metabolism Pathway, Drug metabolism - cytochrome P450 - Homo sapiens (human), Effects of nitric oxide, Hypophosphatasia, Isobutyryl-coa dehydrogenase deficiency, Isovaleric Aciduria, Isovaleric acidemia, JAK-STAT signaling pathway - Homo sapiens (human), Maple Syrup Urine Disease, Mercaptopurine Action Pathway, Mercaptopurine Metabolism Pathway, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Methylmalonate Semialdehyde Dehydrogenase Deficiency, Methylmalonic Aciduria, Nicotinate and Nicotinamide Metabolism, Nicotinate and nicotinamide metabolism - Homo sapiens (human), Nicotine Action Pathway, Nicotine Metabolism, Nicotine Metabolism Pathway, Propionic Acidemia, Retinol metabolism - Homo sapiens (human), Thioguanine Action Pathway, Tryptophan Metabolism, Tryptophan metabolism, Tryptophan metabolism - Homo sapiens (human), Tyrosine metabolism - Homo sapiens (human), Valine, Leucine and Isoleucine Degradation, Valine, leucine and isoleucine degradation - Homo sapiens (human), Vitamin B6 Metabolism, Vitamin B6 activation to pyridoxal phosphate, Vitamin B6 metabolism - Homo sapiens (human), nicotine degradation III, nicotine degradation IV
UniProt: Q06278
Entrez ID: 316
|
Does Knockout of FURIN in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
FURIN
|
cell proliferation
|
T-lymphoma cell line
|
Gene: FURIN (furin, paired basic amino acid cleaving enzyme)
Type: protein-coding
Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: amyloid fibril formation, blastocyst formation, collagen catabolic process, cytokine precursor processing, dibasic protein processing, extracellular matrix disassembly, extracellular matrix organization, negative regulation of inflammatory response to antigenic stimulus, negative regulation of low-density lipoprotein particle receptor catabolic process, negative regulation of nerve growth factor production, negative regulation of transforming growth factor beta1 production, nerve growth factor production, peptide biosynthetic process, peptide hormone processing, plasma lipoprotein particle remodeling, positive regulation of membrane protein ectodomain proteolysis, positive regulation of viral entry into host cell, protein maturation, protein processing, proteolysis, regulation of cholesterol transport, regulation of protein catabolic process, regulation of signal transduction, secretion by cell, signal peptide processing, symbiont entry into host cell, transforming growth factor beta receptor signaling pathway, viral life cycle, viral protein processing, viral translation, zymogen activation, zymogen inhibition; MF: endopeptidase activator activity, endopeptidase activity, heparan sulfate binding, heparin binding, hydrolase activity, metal ion binding, nerve growth factor binding, peptidase activity, peptide binding, protease binding, protein binding, serine-type endopeptidase activity, serine-type endopeptidase inhibitor activity, serine-type peptidase activity; CC: Golgi apparatus, Golgi apparatus subcompartment, Golgi lumen, Golgi membrane, cell surface, endoplasmic reticulum, endosome, endosome membrane, extracellular exosome, extracellular region, extracellular space, membrane, membrane raft, organelle membrane, plasma membrane, trans-Golgi network, trans-Golgi network transport vesicle
Pathways: Activation of Matrix Metalloproteinases, Adherens junctions interactions, Amyloid fiber formation, Anti-inflammatory response favouring Leishmania parasite infection, Assembly Of The HIV Virion, Assembly of active LPL and LIPC lipase complexes, Attachment and Entry, Bacterial Infection Pathways, CD163 mediating an anti-inflammatory response, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Collagen degradation, Degradation of the extracellular matrix, Developmental Biology, Disease, Early SARS-CoV-2 Infection Events, Elastic fibre formation, Expression and Processing of Neurotrophins, Extracellular matrix organization, Formation of the cornified envelope, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Gene expression (Transcription), Generic Transcription Pathway, Glypican 3 network, HIF-1-alpha transcription factor network, HIV Infection, HIV Life Cycle, Induction of Cell-Cell Fusion, Infectious disease, Keratinization, Late Phase of HIV Life Cycle, Late SARS-CoV-2 Infection Events, Leishmania infection, Leishmania parasite growth and survival, Maturation of hRSV A proteins, Metabolism of proteins, NGF processing, Notch signaling pathway, Parasitic Infection Pathways, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Post-translational protein modification, Potential therapeutics for SARS, Pre-NOTCH Expression and Processing, Pre-NOTCH Processing in Golgi, RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Removal of aminoterminal propeptides from gamma-carboxylated proteins, Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) attachment and entry, Respiratory syncytial virus (RSV) genome replication, transcription and translation, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 altering angiogenesis via NRP1, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by NODAL, Signaling by NOTCH, Signaling by NTRKs, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Synthesis and processing of ENV and VPU, TGF-beta receptor signaling activates SMADs, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transport of small molecules, Uptake and actions of bacterial toxins, Uptake and function of anthrax toxins, Viral Infection Pathways, p75(NTR)-mediated signaling, proteolysis and signaling pathway of notch
UniProt: P09958
Entrez ID: 5045
|
Does Knockout of ZCRB1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
ZCRB1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: ZCRB1 (zinc finger CCHC-type and RNA binding motif containing 1)
Type: protein-coding
Summary: Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, metal ion binding, nucleic acid binding, protein binding, zinc ion binding; CC: U12-type spliceosomal complex, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Disease, Early SARS-CoV-2 Infection Events, Infectious disease, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Replication of the SARS-CoV-1 genome, Replication of the SARS-CoV-2 genome, SARS-CoV Infections, SARS-CoV-1 Genome Replication and Transcription, SARS-CoV-1 Infection, SARS-CoV-2 Genome Replication and Transcription, SARS-CoV-2 Infection, Viral Infection Pathways, mRNA Splicing, mRNA Splicing - Minor Pathway
UniProt: Q8TBF4
Entrez ID: 85437
|
Does Knockout of MRPS24 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
MRPS24
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: MRPS24 (mitochondrial ribosomal protein S24)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11. Read-through transcription exists between this gene and the upstream upregulator of cell proliferation (URGCP) gene. [provided by RefSeq, Mar 2011].
Gene Ontology: BP: mitochondrial translation; MF: RNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q96EL2
Entrez ID: 64951
|
Does Knockout of SLC47A2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
SLC47A2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: SLC47A2 (solute carrier family 47 member 2)
Type: protein-coding
Summary: This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: organic cation transport, proton transmembrane transport, transmembrane transport, xenobiotic detoxification by transmembrane export across the plasma membrane; MF: antiporter activity, organic cation transmembrane transporter activity, polyspecific organic cation:proton antiporter activity, transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: apical plasma membrane, membrane, plasma membrane
Pathways: Proximal tubule transport, SLC-mediated transmembrane transport, SLC-mediated transport of organic cations, Transport of small molecules
UniProt: Q86VL8
Entrez ID: 146802
|
Does Knockout of ZBED6 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
ZBED6
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: ZBED6 (zinc finger BED-type containing 6)
Type: protein-coding
Summary: The protein encoded by this transposon-derived intronless gene is a transcriptional repressor that binds to the consensus sequence 5'-GCTCGC-3'. The encoded protein has been shown to repress IGF2 transcription. This gene is located within the first intron of the ZC3H11A gene. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: blastocyst hatching, negative regulation of DNA-templated transcription, negative regulation of muscle cell differentiation, negative regulation of transcription by RNA polymerase II, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, metal ion binding, protein dimerization activity, transcription cis-regulatory region binding, zinc ion binding; CC: centriolar satellite, chromatin, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: P86452
Entrez ID: 100381270
|
Does Knockout of HAUS5 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
HAUS5
|
cell proliferation
|
Bladder Carcinoma
|
Gene: HAUS5 (HAUS augmin like complex subunit 5)
Type: protein-coding
Summary: HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010].
Gene Ontology: BP: cell division, centrosome cycle, regulation of microtubule nucleation, spindle assembly; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule, mitotic spindle microtubule, spindle
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: O94927
Entrez ID: 23354
|
Does Knockout of ACTR1A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
ACTR1A
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ACTR1A (actin related protein 1A)
Type: protein-coding
Summary: This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: ATP binding, nucleotide binding, protein binding; CC: cell cortex, centrosome, cytoplasm, cytoskeleton, cytosol, dynactin complex, extracellular exosome, microtubule associated complex, microtubule organizing center
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Salmonella infection - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P61163
Entrez ID: 10121
|
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