prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of DNASE2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | DNASE2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: DNASE2 (deoxyribonuclease 2, lysosomal)
Type: protein-coding
Summary: This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been... |
Does Knockout of GTF2E1 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | GTF2E1 | cell proliferation | Multiple Myeloma Cell Line | Gene: GTF2E1 (general transcription factor IIE subunit 1)
Type: protein-coding
Summary: Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of transcription factor TFIID complex and transcrip... |
Does Knockout of EYS in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | EYS | cell proliferation | Melanoma Cell Line | Gene: EYS (EGF-like photoreceptor maintenance factor)
Type: protein-coding
Summary: The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis ... |
Does Knockout of PROCR in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | PROCR | cell proliferation | Medulloblastoma Cell Line | Gene: PROCR (protein C receptor)
Type: protein-coding
Summary: The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activati... |
Does Knockout of TRAPPC1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | TRAPPC1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: TRAPPC1 (trafficking protein particle complex subunit 1)
Type: protein-coding
Summary: This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) ... |
Does Knockout of SUCNR1 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | SUCNR1 | response to virus | Hepatoma Cell Line | Gene: SUCNR1 (succinate receptor 1)
Type: protein-coding
Summary: This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hyp... |
Does Knockout of DNM3 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | DNM3 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: DNM3 (dynamin 3)
Type: protein-coding
Summary: This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing ... |
Does Knockout of PSMC3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | PSMC3 | cell proliferation | Endometrial Cancer Cell Line | Gene: PSMC3 (proteasome 26S subunit, ATPase 3)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are co... |
Does Knockout of PDAP1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | PDAP1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: PDAP1 (PDGFA associated protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a l... |
Does Knockout of RPSA in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | RPSA | cell proliferation | Colonic Cancer Cell Line | Gene: RPSA (ribosomal protein SA)
Type: protein-coding
Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migratio... |
Does Knockout of ZNF90 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | ZNF90 | cell proliferation | Medulloblastoma Cell Line | Gene: ZNF90 (zinc finger protein 90)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-te... |
Does Knockout of BCCIP in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | BCCIP | cell proliferation | Astrocytoma Cell Line | Gene: BCCIP (BRCA2 and CDKN1A interacting protein)
Type: protein-coding
Summary: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology w... |
Does Knockout of PIK3R5 in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | PIK3R5 | cell proliferation | Bladder Carcinoma | Gene: PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5)
Type: protein-coding
Summary: Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival ... |
Does Knockout of DDX39B in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | DDX39B | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: DDX39B (DExD-box helicase 39B)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleop... |
Does Knockout of FXYD4 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | FXYD4 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: FXYD4 (FXYD domain containing ion transport regulator 4)
Type: protein-coding
Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino a... |
Does Knockout of BOD1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | BOD1 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: BOD1 (biorientation of chromosomes in cell division 1)
Type: protein-coding
Summary: Enables protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Involved in mitotic sister chromatid segregation; negative regulation of phosphoprotein phosphatase activity; and protein... |
Does Knockout of RPL12 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | RPL12 | cell proliferation | Renal Cancer Cell Line | Gene: RPL12 (ribosomal protein L12)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of PCNA in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | PCNA | cell proliferation | Cancer Cell Line | Gene: PCNA (proliferating cell nuclear antigen)
Type: protein-coding
Summary: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replicatio... |
Does Knockout of ATG10 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | ATG10 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ATG10 (autophagy related 10)
Type: protein-coding
Summary: Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conju... |
Does Knockout of MAPK8IP3 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | MAPK8IP3 | cell proliferation | Multiple Myeloma Cell Line | Gene: MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3)
Type: protein-coding
Summary: The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse... |
Does Knockout of CNPY2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | CNPY2 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: CNPY2 (canopy FGF signaling regulator 2)
Type: protein-coding
Summary: Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of gene expression, regulation of low-density lipoprotein particle clearance;... |
Does Knockout of MRC2 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | MRC2 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: MRC2 (mannose receptor C-type 2)
Type: protein-coding
Summary: This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating t... |
Does Knockout of CLDN18 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | CLDN18 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: CLDN18 (claudin 18)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the para... |
Does Knockout of GJB1 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | GJB1 | cell proliferation | Cancer Cell Line | Gene: GJB1 (gap junction protein beta 1)
Type: protein-coding
Summary: This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cell... |
Does Knockout of NR0B1 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | NR0B1 | response to virus | Lung Cancer Cell Line | Gene: NR0B1 (nuclear receptor subfamily 0 group B member 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also function... |
Does Knockout of ATF4 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | ATF4 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: ATF4 (activating transcription factor 4)
Type: protein-coding
Summary: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also is... |
Does Knockout of TWIST2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | TWIST2 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: TWIST2 (twist family bHLH transcription factor 2)
Type: protein-coding
Summary: The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype du... |
Does Knockout of ETF1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | ETF1 | cell proliferation | Colonic Cancer Cell Line | Gene: ETF1 (eukaryotic translation termination factor 1)
Type: protein-coding
Summary: This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a co... |
Does Knockout of SRP54 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | SRP54 | cell proliferation | Medulloblastoma Cell Line | Gene: SRP54 (signal recognition particle 54)
Type: protein-coding
Summary: Enables several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Contributes to GTPase activity. Involved in granulocyte differentiat... |
Does Knockout of MIR8087 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | MIR8087 | response to chemicals | Monocytic Leukemia Cell Line | Gene: MIR8087 (microRNA 8087)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Activation of FNDC11 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | FNDC11 | response to virus | Hepatoma Cell Line | Gene: FNDC11 (fibronectin type III domain containing 11)
Type: protein-coding
Summary: fibronectin type III domain containing 11
Gene Ontology:
Pathways:
UniProt: Q9BVV2
Entrez ID: 79025 |
Does Knockout of TRIM42 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | TRIM42 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: TRIM42 (tripartite motif containing 42)
Type: protein-coding
Summary: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008].
... |
Does Knockout of ATP6V1B2 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | ATP6V1B2 | cell proliferation | Colonic Cancer Cell Line | Gene: ATP6V1B2 (ATPase H+ transporting V1 subunit B2)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intr... |
Does Knockout of ZNHIT2 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | ZNHIT2 | cell proliferation | Prostate Cancer Cell Line | Gene: ZNHIT2 (zinc finger HIT-type containing 2)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: Q9UHR... |
Does Knockout of DOK1 in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | DOK1 | cell proliferation | Prostate Cancer Cell Line | Gene: DOK1 (docking protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Sever... |
Does Knockout of DPH6 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | DPH6 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: DPH6 (diphthamine biosynthesis 6)
Type: protein-coding
Summary: Enables diphthine-ammonia ligase activity. Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of CILP2 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | CILP2 | cell proliferation | Breast Cancer Cell Line | Gene: CILP2 (cartilage intermediate layer protein 2)
Type: protein-coding
Summary: Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: alkaline phosphatase activity, dinucleotide phosphatase activity; CC: extracellular exosome, extracellular... |
Does Knockout of NPHS1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | NPHS1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: NPHS1 (NPHS1 adhesion molecule, nephrin)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1... |
Does Knockout of PDCD2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | PDCD2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: PDCD2 (programmed cell death 2)
Type: protein-coding
Summary: This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center developme... |
Does Knockout of CLEC1A in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | CLEC1A | response to virus | Hepatoma Cell Line | Gene: CLEC1A (C-type lectin domain family 1 member A)
Type: protein-coding
Summary: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling,... |
Does Knockout of POLR1B in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | POLR1B | cell proliferation | Neuroblastoma Cell Line | Gene: POLR1B (RNA polymerase I subunit B)
Type: protein-coding
Summary: Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depe... |
Does Knockout of CAPN15 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | CAPN15 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: CAPN15 (calpain 15)
Type: protein-coding
Summary: This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development... |
Does Knockout of MYBPHL in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | MYBPHL | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: MYBPHL (myosin binding protein H like)
Type: protein-coding
Summary: This gene encodes a protein with two immunoglobulin superfamily domains and a fibronectin 3 domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012].
Gene Ontology: BP: biologi... |
Does Knockout of EEF1G in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | EEF1G | cell proliferation | Endometrial Cancer Cell Line | Gene: EEF1G (eukaryotic translation elongation factor 1 gamma)
Type: protein-coding
Summary: This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase dom... |
Does Knockout of GALNT5 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | GALNT5 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: GALNT5 (polypeptide N-acetylgalactosaminyltransferase 5)
Type: protein-coding
Summary: The protein encoded by this gene is a membrane-bound polypeptide N-acetylgalactosaminyltransferase that is found in the Golgi. The encoded protein catalyzes the first step in the mucin-type O-glycosylation of Go... |
Does Knockout of GNG7 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | GNG7 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: GNG7 (G protein subunit gamma 7)
Type: protein-coding
Summary: Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of adenylate cyclase activity. Predicted to act upstream of or within behavioral fear ... |
Does Knockout of CBLB in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | CBLB | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: CBLB (Cbl proto-oncogene B)
Type: protein-coding
Summary: This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of i... |
Does Knockout of CAND2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | CAND2 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: CAND2 (cullin associated and neddylation dissociated 2 (putative))
Type: protein-coding
Summary: Predicted to enable TBP-class protein binding activity. Predicted to be involved in SCF complex assembly; positive regulation of transcription, DNA-templated; and protein ubiquitination. Located in cyt... |
Does Knockout of CRISPLD1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | CRISPLD1 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: CRISPLD1 (cysteine rich secretory protein LCCL domain containing 1)
Type: protein-coding
Summary: Involved in face morphogenesis. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: face morphogenesis, hematopoietic stem cell homeostas... |
Does Knockout of DHX33 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | DHX33 | cell proliferation | Multiple Myeloma Cell Line | Gene: DHX33 (DEAH-box helicase 33)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving a... |
Does Knockout of SNUPN in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | SNUPN | cell proliferation | Medulloblastoma Cell Line | Gene: SNUPN (snurportin 1)
Type: protein-coding
Summary: The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the S... |
Does Knockout of NAF1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | NAF1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: NAF1 (nuclear assembly factor 1 ribonucleoprotein)
Type: protein-coding
Summary: Enables identical protein binding activity and telomerase RNA binding activity. Involved in regulation of nucleobase-containing compound metabolic process; ribosome biogenesis; and telomerase holoenzyme complex assemb... |
Does Knockout of PAFAH1B1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | PAFAH1B1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1)
Type: protein-coding
Summary: This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alph... |
Does Knockout of UBE2S in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | UBE2S | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: UBE2S (ubiquitin conjugating enzyme E2 S)
Type: protein-coding
Summary: This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ub... |
Does Knockout of MRPL35 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | MRPL35 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: MRPL35 (mitochondrial ribosomal protein L35)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of NIP7 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | NIP7 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: NIP7 (nucleolar pre-rRNA processing protein NIP7)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:... |
Does Knockout of RPL29 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | RPL29 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: RPL29 (ribosomal protein L29)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of VPS45 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | VPS45 | cell proliferation | Monocytic Leukemia Cell Line | Gene: VPS45 (vacuolar protein sorting 45 homolog)
Type: protein-coding
Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved... |
Does Knockout of STEAP3 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | STEAP3 | cell proliferation | Cancer Cell Line | Gene: STEAP3 (STEAP3 metalloreductase)
Type: protein-coding
Summary: This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting ... |
Does Knockout of FBP2 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | FBP2 | cell proliferation | Multiple Myeloma Cell Line | Gene: FBP2 (fructose-bisphosphatase 2)
Type: protein-coding
Summary: This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate... |
Does Activation of MITD1 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | MITD1 | response to virus | Hepatoma Cell Line | Gene: MITD1 (microtubule interacting and trafficking domain containing 1)
Type: protein-coding
Summary: Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as... |
Does Knockout of NDUFV2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | NDUFV2 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2)
Type: protein-coding
Summary: The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is loca... |
Does Knockout of DDX56 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | DDX56 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: DDX56 (DEAD-box helicase 56)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alterati... |
Does Knockout of AGL in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | AGL | cell proliferation | Prostate Cancer Cell Line | Gene: AGL (amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase)
Type: protein-coding
Summary: This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-g... |
Does Knockout of SYT14 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | SYT14 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: SYT14 (synaptotagmin 14)
Type: protein-coding
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in t... |
Does Knockout of CPSF4 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | CPSF4 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: CPSF4 (cleavage and polyadenylation specific factor 4)
Type: protein-coding
Summary: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subuni... |
Does Knockout of DDX18 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | DDX18 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: DDX18 (DEAD-box helicase 18)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiatio... |
Does Knockout of SMC3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | SMC3 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: SMC3 (structural maintenance of chromosomes 3)
Type: protein-coding
Summary: This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenanc... |
Does Knockout of NRF1 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | NRF1 | cell proliferation | Renal Cancer Cell Line | Gene: NRF1 (nuclear respiratory factor 1)
Type: protein-coding
Summary: This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthes... |
Does Knockout of CLTCL1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | CLTCL1 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: CLTCL1 (clathrin heavy chain like 1)
Type: protein-coding
Summary: This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome,... |
Does Knockout of DHX15 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | DHX15 | cell proliferation | Colonic Cancer Cell Line | Gene: DHX15 (DEAH-box helicase 15)
Type: protein-coding
Summary: The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, antiviral innate immune response, defense response to bact... |
Does Knockout of MGST1 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | MGST1 | cell proliferation | Cancer Cell Line | Gene: MGST1 (microsomal glutathione S-transferase 1)
Type: protein-coding
Summary: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators... |
Does Knockout of FGF22 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | FGF22 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: FGF22 (fibroblast growth factor 22)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embry... |
Does Knockout of PUM1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | PUM1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: PUM1 (pumilio RNA binding family member 1)
Type: protein-coding
Summary: This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains ... |
Does Knockout of VPS16 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | VPS16 | cell proliferation | Renal Cancer Cell Line | Gene: VPS16 (VPS16 core subunit of CORVET and HOPS complexes)
Type: protein-coding
Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) ge... |
Does Knockout of PLK4 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | PLK4 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: PLK4 (polo like kinase 4)
Type: protein-coding
Summary: This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Thre... |
Does Knockout of EAF1 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | EAF1 | cell proliferation | Cancer Cell Line | Gene: EAF1 (ELL associated factor 1)
Type: protein-coding
Summary: Enables transcription elongation regulator activity. Involved in regulation of transcription elongation from RNA polymerase II promoter. Located in intercellular bridge and nuclear body. Part of transcription elongation factor complex. [... |
Does Knockout of ING4 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | ING4 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: ING4 (inhibitor of growth family member 4)
Type: protein-coding
Summary: This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl trans... |
Does Knockout of OFD1 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | OFD1 | response to virus | Lung Cancer Cell Line | Gene: OFD1 (OFD1 centriole and centriolar satellite protein)
Type: protein-coding
Summary: This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, h... |
Does Knockout of PTBP3 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | PTBP3 | cell proliferation | Cancer Cell Line | Gene: PTBP3 (polypyrimidine tract binding protein 3)
Type: protein-coding
Summary: The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different iso... |
Does Knockout of SNRPG in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | SNRPG | cell proliferation | Medulloblastoma Cell Line | Gene: SNRPG (small nuclear ribonucleoprotein polypeptide G)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear rib... |
Does Knockout of TP53BP2 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | TP53BP2 | cell proliferation | Gastric Cancer Cell Line | Gene: TP53BP2 (tumor protein p53 binding protein 2)
Type: protein-coding
Summary: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is ... |
Does Knockout of CADPS in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | CADPS | response to virus | Cervical Adenocarcinoma Cell Line | Gene: CADPS (calcium dependent secretion activator)
Type: protein-coding
Summary: This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dep... |
Does Knockout of PGPEP1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | PGPEP1 | cell proliferation | Medulloblastoma Cell Line | Gene: PGPEP1 (pyroglutamyl-peptidase I)
Type: protein-coding
Summary: The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuro... |
Does Knockout of NUDCD1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | NUDCD1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: NUDCD1 (NudC domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in immune system process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
... |
Does Knockout of HDHD5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | HDHD5 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: HDHD5 (haloacid dehalogenase like hydrolase domain containing 5)
Type: protein-coding
Summary: Predicted to be involved in glycerophospholipid biosynthetic process. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: mitochondri... |
Does Knockout of AMIGO1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | AMIGO1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: AMIGO1 (adhesion molecule with Ig like domain 1)
Type: protein-coding
Summary: Predicted to enable potassium channel regulator activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion vi... |
Does Knockout of DMKN in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | DMKN | cell proliferation | Bladder Carcinoma | Gene: DMKN (dermokine)
Type: protein-coding
Summary: This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with uni... |
Does Knockout of PAK6 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | PAK6 | cell proliferation | Glioblastoma Cell Line | Gene: PAK6 (p21 (RAC1) activated kinase 6)
Type: protein-coding
Summary: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in... |
Does Knockout of WFDC10B in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | WFDC10B | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: WFDC10B (WAP four-disulfide core domain 10B)
Type: protein-coding
Summary: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions a... |
Does Knockout of PRAME in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | PRAME | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: PRAME (PRAME nuclear receptor transcriptional regulator)
Type: protein-coding
Summary: This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts ... |
Does Knockout of RPRD1B in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | RPRD1B | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: RPRD1B (regulation of nuclear pre-mRNA domain containing 1B)
Type: protein-coding
Summary: Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in positive regulation of cell population proliferation; regulation of cell cycle process; and regulation o... |
Does Knockout of AOX1 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | AOX1 | response to virus | Lung Cancer Cell Line | Gene: AOX1 (aldehyde oxidase 1)
Type: protein-coding
Summary: Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008].
Gene Ontolog... |
Does Knockout of FURIN in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | FURIN | cell proliferation | T-lymphoma cell line | Gene: FURIN (furin, paired basic amino acid cleaving enzyme)
Type: protein-coding
Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the se... |
Does Knockout of ZCRB1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | ZCRB1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: ZCRB1 (zinc finger CCHC-type and RNA binding motif containing 1)
Type: protein-coding
Summary: Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type... |
Does Knockout of MRPS24 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | MRPS24 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: MRPS24 (mitochondrial ribosomal protein S24)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of SLC47A2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | SLC47A2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: SLC47A2 (solute carrier family 47 member 2)
Type: protein-coding
Summary: This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial... |
Does Knockout of ZBED6 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | ZBED6 | response to chemicals | Colorectal Cancer Cell Line | Gene: ZBED6 (zinc finger BED-type containing 6)
Type: protein-coding
Summary: The protein encoded by this transposon-derived intronless gene is a transcriptional repressor that binds to the consensus sequence 5'-GCTCGC-3'. The encoded protein has been shown to repress IGF2 transcription. This gene is lo... |
Does Knockout of HAUS5 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | HAUS5 | cell proliferation | Bladder Carcinoma | Gene: HAUS5 (HAUS augmin like complex subunit 5)
Type: protein-coding
Summary: HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin compl... |
Does Knockout of ACTR1A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | ACTR1A | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ACTR1A (actin related protein 1A)
Type: protein-coding
Summary: This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of... |
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