prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of CENPO in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
CENPO
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: CENPO (centromere protein O)
Type: protein-coding
Summary: This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: centromere complex assembly, chromosome segregation; CC: Mis6-Sim4 complex, chromosome, chromosome, centromeric region, cytosol, inner kinetochore, kinetochore, nuclear body, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9BU64
Entrez ID: 79172
|
Does Knockout of PSMA3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
PSMA3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PSMA3 (proteasome 20S subunit alpha 3)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: protein binding, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Aurora B signaling, Huntington disease - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), proteasome complex
UniProt: P25788
Entrez ID: 5684
|
Does Knockout of UTP6 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
UTP6
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: UTP6 (UTP6 small subunit processome component)
Type: protein-coding
Summary: Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA processing, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis; MF: protein binding, snoRNA binding; CC: Pwp2p-containing subcomplex of 90S preribosome, chromosome, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NYH9
Entrez ID: 55813
|
Does Knockout of RRP9 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
RRP9
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: RRP9 (ribosomal RNA processing 9, U3 small nucleolar RNA binding protein)
Type: protein-coding
Summary: This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). [provided by RefSeq, Oct 2012].
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis; MF: RNA binding, U3 snoRNA binding, protein binding, snoRNA binding; CC: box C/D methylation guide snoRNP complex, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O43818
Entrez ID: 9136
|
Does Knockout of RRP12 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
RRP12
|
cell proliferation
|
Cancer Cell Line
|
Gene: RRP12 (ribosomal RNA processing 12 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in cytosol; nucleolus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding; CC: cytosol, membrane, nuclear membrane, nucleolus, nucleus, plasma membrane
Pathways:
UniProt: Q5JTH9
Entrez ID: 23223
|
Does Knockout of C3orf38 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
C3orf38
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: C3orf38 (chromosome 3 open reading frame 38)
Type: protein-coding
Summary: Involved in positive regulation of apoptotic process. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, positive regulation of apoptotic process
Pathways:
UniProt: Q5JPI3
Entrez ID: 285237
|
Does Knockout of PREB in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
PREB
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PREB (prolactin regulatory element binding)
Type: protein-coding
Summary: This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: COPII vesicle coating, COPII-coated vesicle cargo loading, endoplasmic reticulum to Golgi vesicle-mediated transport, lipoprotein transport, protein transport, regulation of COPII vesicle coating, vesicle-mediated transport; MF: DNA binding, GTPase binding, guanyl-nucleotide exchange factor activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, IRE1alpha activates chaperones, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Transport to the Golgi and subsequent modification, Unfolded Protein Response (UPR), Vesicle-mediated transport, XBP1(S) activates chaperone genes
UniProt: Q9HCU5
Entrez ID: 10113
|
Does Knockout of POLR2K in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
POLR2K
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: POLR2K (RNA polymerase II, I and III subunit K)
Type: protein-coding
Summary: This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, regulation of transcription by RNA polymerase I, transcription by RNA polymerase II, transcription by RNA polymerase III; MF: DNA binding, DNA-directed RNA polymerase activity, metal ion binding, protein binding, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, RNA polymerase II, core complex, RNA polymerase III complex, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Abortive elongation of HIV-1 transcript in the absence of Tat, Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, B-WICH complex positively regulates rRNA expression, Cell Cycle, Chromosome Maintenance, Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , DNA Repair, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dual incision in TC-NER, ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, Eukaryotic Transcription Initiation, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene Silencing by RNA, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, HIV elongation arrest and recovery, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inhibition of DNA recombination at telomere, Innate Immune System, Late Phase of HIV Life Cycle, Metabolism of RNA, MicroRNA (miRNA) biogenesis, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, PIWI-interacting RNA (piRNA) biogenesis, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, Positive epigenetic regulation of rRNA expression, Processing of Capped Intron-Containing Pre-mRNA, Pyrimidine metabolism, RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Telomere Maintenance, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by small RNAs, Viral Infection Pathways, Viral Messenger RNA Synthesis, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P53803
Entrez ID: 5440
|
Does Knockout of ALMS1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
ALMS1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: ALMS1 (ALMS1 centrosome and basal body associated protein)
Type: protein-coding
Summary: This gene encodes a protein containing a large tandem-repeat domain as well as additional low complexity regions. The encoded protein functions in microtubule organization, particularly in the formation and maintanance of cilia. Mutations in this gene cause Alstrom syndrome. There is a pseudogene for this gene located adjacent in the same region of chromosome 2. Alternative splice variants have been described but their full length nature has not been determined. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: endosomal transport, positive regulation of cold-induced thermogenesis, regulation of centriole replication, regulation of stress fiber assembly; CC: cell projection, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton, mitochondrion, nucleoplasm, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Ciliopathies, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q8TCU4
Entrez ID: 7840
|
Does Knockout of MED28 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
MED28
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: MED28 (mediator complex subunit 28)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Predicted to act upstream of or within negative regulation of smooth muscle cell differentiation and stem cell population maintenance. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, negative regulation of smooth muscle cell differentiation, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, somatic stem cell population maintenance; MF: actin binding, protein binding; CC: core mediator complex, cortical actin cytoskeleton, cytoplasm, cytoskeleton, mediator complex, membrane, nucleoplasm, nucleus
Pathways: Adipogenesis, Developmental Biology, Disease, Infectious disease, Metabolism, Metabolism of lipids, PPARA activates gene expression, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9H204
Entrez ID: 80306
|
Does Knockout of PPP3R1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
PPP3R1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha)
Type: protein-coding
Summary: Enables cyclosporin A binding activity; phosphatase binding activity; and protein domain specific binding activity. Involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Part of calcineurin complex. Implicated in Alzheimer's disease and dilated cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Schwann cell development, branching involved in blood vessel morphogenesis, calcineurin-NFAT signaling cascade, epithelial to mesenchymal transition, heart development, lung epithelial cell differentiation, myelination in peripheral nervous system, negative regulation of calcium ion import across plasma membrane, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of calcium ion import across plasma membrane, positive regulation of transcription by RNA polymerase II, postsynaptic modulation of chemical synaptic transmission, protein import into nucleus, protein localization to nucleus, regulation of postsynaptic neurotransmitter receptor internalization, regulation of synaptic vesicle cycle; MF: calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity, calcium-dependent protein serine/threonine phosphatase regulator activity, calmodulin binding, metal ion binding, phosphatase binding, phosphoprotein phosphatase activity, protein binding, protein domain specific binding; CC: Schaffer collateral - CA1 synapse, calcineurin complex, cytoplasm, cytosol, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane, nucleoplasm, parallel fiber to Purkinje cell synapse, plasma membrane, postsynapse, protein serine/threonine phosphatase complex, sarcolemma, synapse
Pathways: Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amphetamine addiction - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Axon guidance - Homo sapiens (human), B cell receptor signaling pathway - Homo sapiens (human), C-type lectin receptor signaling pathway - Homo sapiens (human), Calcium signaling pathway - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Energy Metabolism, Glucagon signaling pathway - Homo sapiens (human), Glutamatergic synapse - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Initiation of transcription and translation elongation at the HIV-1 LTR, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Natural killer cell mediated cytotoxicity - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Osteoclast differentiation - Homo sapiens (human), Oxytocin signaling pathway - Homo sapiens (human), PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Regucalcin in proximal tubule epithelial kidney cells, Renin secretion - Homo sapiens (human), T cell receptor signaling pathway - Homo sapiens (human), TFs regulate miRNAs related to cardiac hypertrophy, Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Tuberculosis - Homo sapiens (human), VEGF signaling pathway - Homo sapiens (human), Vitamin D in inflammatory diseases, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P63098
Entrez ID: 5534
|
Does Knockout of PSMA7 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
PSMA7
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: PSMA7 (proteasome 20S subunit alpha 7)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: identical protein binding, protein binding; CC: cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), proteasome complex, y branching of actin filaments
UniProt: O14818
Entrez ID: 5688
|
Does Activation of IZUMO4 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
IZUMO4
|
protein/peptide accumulation
|
T cell
|
Gene: IZUMO4 (IZUMO family member 4)
Type: protein-coding
Summary: Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular region, nucleus
Pathways: Acrosome Reaction and Sperm:Oocyte Membrane Binding, Fertilization, Reproduction
UniProt: Q1ZYL8
Entrez ID: 113177
|
Does Knockout of PYROXD1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
PYROXD1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1)
Type: protein-coding
Summary: This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other proteins. The encoded protein belongs to the class I pyridine nucleotide-disulphide oxidoreductase family but lacks the C-terminal dimerization domain found in other family members and instead has a C-terminal nitrile reductase domain. It localizes to the nucleus and to striated sarcomeric compartments. Naturally occurring mutations in this gene cause early-onset myopathy with internalized nuclei and myofibrillar disorganization. A pseudogene of this gene has been defined on chromosome 11. [provided by RefSeq, Apr 2017].
Gene Ontology: MF: NAD(P)H oxidase H2O2-forming activity, oxidoreductase activity, protein binding; CC: cytoplasm, nucleus, sarcomere
Pathways:
UniProt: Q8WU10
Entrez ID: 79912
|
Does Knockout of TARDBP in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
TARDBP
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: TARDBP (TAR DNA binding protein)
Type: protein-coding
Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, 3'-UTR-mediated mRNA stabilization, RNA splicing, amyloid fibril formation, gene expression, host-mediated suppression of viral transcription, mRNA processing, negative regulation of gene expression, negative regulation of protein phosphorylation, nuclear inner membrane organization, positive regulation of insulin secretion, positive regulation of protein import into nucleus, regulation of apoptotic process, regulation of cell cycle, regulation of circadian rhythm, regulation of gene expression, regulation of protein stability, response to endoplasmic reticulum stress, rhythmic process; MF: DNA binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, identical protein binding, lipid binding, mRNA 3'-UTR binding, molecular condensate scaffold activity, nucleic acid binding, pre-mRNA intronic binding, protein binding; CC: chromatin, cytoplasm, cytoplasmic stress granule, interchromatin granule, mitochondrion, nuclear speck, nucleoplasm, nucleus, perichromatin fibrils
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), MECP2 and Associated Rett Syndrome, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), RNA transport - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q13148
Entrez ID: 23435
|
Does Knockout of SULT1C4 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
SULT1C4
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SULT1C4 (sulfotransferase family 1C member 4)
Type: protein-coding
Summary: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate metabolic process, doxorubicin metabolic process, ethanol catabolic process, flavonoid metabolic process, sulfation, xenobiotic metabolic process; MF: aryl sulfotransferase activity, sulfotransferase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Biological oxidations, Cytosolic sulfonation of small molecules, Drug ADME, Metabolism, Metapathway biotransformation Phase I and II, Paracetamol ADME, Phase II - Conjugation of compounds, Sulfation Biotransformation Reaction
UniProt: O75897
Entrez ID: 27233
|
Does Knockout of OSGEP in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
OSGEP
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: OSGEP (O-sialoglycoprotein endopeptidase)
Type: protein-coding
Summary: Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytoplasm; nuclear speck; and plasma membrane. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 3. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: tRNA modification, tRNA processing, tRNA threonylcarbamoyladenosine modification; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, metal ion binding, protein binding, tRNA N(6)-L-threonylcarbamoyladenine synthase activity, transferase activity; CC: EKC/KEOPS complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Metabolism of RNA, tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q9NPF4
Entrez ID: 55644
|
Does Knockout of NOP2 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
NOP2
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: NOP2 (NOP2 nucleolar protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosomal large subunit assembly. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA methylation, RNA processing, maturation of LSU-rRNA, methylation, positive regulation of cell population proliferation, rRNA base methylation, rRNA processing, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis; MF: RNA binding, RNA methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, protein binding, rRNA (cytosine-C5-)-methyltransferase activity, transferase activity; CC: nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Imatinib and Chronic Myeloid Leukemia, Metabolism of RNA, RNA Polymerase II Transcription, TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46087
Entrez ID: 4839
|
Does Knockout of UNC119B in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
UNC119B
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: UNC119B (unc-119 lipid binding chaperone B)
Type: protein-coding
Summary: Enables lipid binding activity. Involved in cilium assembly and lipoprotein transport. Located in ciliary transition zone. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell projection organization, cilium assembly, lipoprotein transport, nervous system development, protein transport; MF: lipid binding, protein binding; CC: cell projection, ciliary transition zone, cilium, cytosol
Pathways: Cargo trafficking to the periciliary membrane, Cilium Assembly, Organelle biogenesis and maintenance, Trafficking of myristoylated proteins to the cilium
UniProt: A6NIH7
Entrez ID: 84747
|
Does Knockout of OR52A5 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
OR52A5
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: OR52A5 (olfactory receptor family 52 subfamily A member 5)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, nervous system process, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q9H2C5
Entrez ID: 390054
|
Does Knockout of LANCL3 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
LANCL3
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: LANCL3 (LanC like family member 3)
Type: protein-coding
Summary: Predicted to be involved in carbohydrate metabolic process. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: carbohydrate metabolic process, peptide modification
Pathways:
UniProt: Q6ZV70
Entrez ID: 347404
|
Does Knockout of DNAJC17 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
DNAJC17
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: DNAJC17 (DnaJ heat shock protein family (Hsp40) member C17)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and toxin transport. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, spliceosomal complex disassembly; MF: RNA binding, nucleic acid binding, protein binding; CC: cytoplasm, nucleus, spliceosomal complex
Pathways:
UniProt: Q9NVM6
Entrez ID: 55192
|
Does Knockout of ARL15 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
ARL15
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ARL15 (ARF like GTPase 15)
Type: protein-coding
Summary: Predicted to enable GTP binding activity and GTPase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTP binding, GTPase activity, molecular_function, nucleotide binding, protein binding
Pathways:
UniProt: Q9NXU5
Entrez ID: 54622
|
Does Knockout of MIR891B in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
MIR891B
|
response to virus
|
Hepatoma Cell Line
|
Gene: MIR891B (microRNA 891b)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100126304
|
Does Knockout of PCDHGC3 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
PCDHGC3
|
cell proliferation
|
Cancer Cell Line
|
Gene: PCDHGC3 (protocadherin gamma subfamily C, 3)
Type: protein-coding
Summary: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of neuron apoptotic process, nervous system development, synapse organization; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9UN70
Entrez ID: 5098
|
Does Knockout of KIAA0408 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
KIAA0408
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: KIAA0408 (KIAA0408)
Type: protein-coding
Summary: KIAA0408
Gene Ontology:
Pathways:
UniProt: Q6ZU52
Entrez ID: 9729
|
Does Knockout of SDHB in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
SDHB
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: SDHB (succinate dehydrogenase complex iron sulfur subunit B)
Type: protein-coding
Summary: This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits. This enzyme complex converts succinate to fumarate which releases electrons as part of the citric acid cycle, and the enzyme complex additionally provides an attachment site for released electrons to be transferred to the oxidative phosphorylation pathway. The SDH enzyme complex plays a role in oxygen-related gene regulation through its conversion of succinate, which is an oxygen sensor that stabilizes the hypoxia-inducible factor 1 (HIF1) transcription factor. Sporadic and familial mutations in this gene result in paragangliomas, pheochromocytoma, and gastrointestinal stromal tumors, supporting a link between mitochondrial dysfunction and tumorigenesis. Mutations in this gene are also implicated in nuclear type 4 mitochondrial complex II deficiency. [provided by RefSeq, Jun 2022].
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, respiratory electron transport chain, succinate metabolic process, tricarboxylic acid cycle; MF: 2 iron, 2 sulfur cluster binding, 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, electron transfer activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, protein binding, succinate dehydrogenase (quinone) activity, ubiquinone binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleoplasm, plasma membrane, respiratory chain complex II (succinate dehydrogenase)
Pathways: 2-ketoglutarate dehydrogenase complex deficiency, Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Citrate cycle (TCA cycle) - Homo sapiens (human), Citric Acid Cycle, Citric acid cycle (TCA cycle), Congenital lactic acidosis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Fumarase deficiency, Glutaminolysis and Cancer, Huntington disease - Homo sapiens (human), Maturation of TCA enzymes and regulation of TCA cycle, Metabolic reprogramming in colon cancer, Metabolism, Mitochondrial CII Assembly, Mitochondrial Electron Transport Chain, Mitochondrial complex II deficiency, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Pyruvate dehydrogenase deficiency (E2), Pyruvate dehydrogenase deficiency (E3), Respiratory electron transport, TCA Cycle (aka Krebs or citric acid cycle), TCA cycle, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate, Thermogenesis - Homo sapiens (human), Warburg Effect, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P21912
Entrez ID: 6390
|
Does Knockout of LYPD8 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
LYPD8
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: LYPD8 (LY6/PLAUR domain containing 8)
Type: protein-coding
Summary: Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: defense response to Gram-negative bacterium; CC: extracellular region, extracellular space, membrane, plasma membrane, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q6UX82
Entrez ID: 646627
|
Does Knockout of LPCAT4 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,631
|
Knockout
|
LPCAT4
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: LPCAT4 (lysophosphatidylcholine acyltransferase 4)
Type: protein-coding
Summary: Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008].
Gene Ontology: BP: lipid metabolic process, phosphatidic acid biosynthetic process, phosphatidylcholine acyl-chain remodeling, phosphatidylethanolamine acyl-chain remodeling, phosphatidylglycerol acyl-chain remodeling, phosphatidylserine acyl-chain remodeling, phospholipid biosynthetic process, phospholipid metabolic process; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, 1-acylglycerophosphocholine O-acyltransferase activity, 1-acylglycerophosphoethanolamine O-acyltransferase activity, 1-acylglycerophosphoserine O-acyltransferase activity, 1-alkenylglycerophosphoethanolamine O-acyltransferase activity, 1-alkylglycerophosphocholine O-acetyltransferase activity, 2-acylglycerol-3-phosphate O-acyltransferase activity, O-acyltransferase activity, acyltransferase activity, lysophosphatidic acid acyltransferase activity, lysophospholipid acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Acyl chain remodelling of PG, Acyl chain remodelling of PS, CDP-diacylglycerol biosynthesis, Ether lipid metabolism - Homo sapiens (human), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA, triacylglycerol biosynthesis
UniProt: Q643R3
Entrez ID: 254531
|
Does Knockout of SKP2 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
SKP2
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: SKP2 (S-phase kinase associated protein 2)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: DNA double-strand break processing, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cellular response to cell-matrix adhesion, defense response to virus, immune system process, innate immune response, positive regulation of double-strand break repair via homologous recombination, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of protein polyubiquitination, positive regulation of smooth muscle cell proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein K63-linked ubiquitination, protein localization to site of double-strand break, protein polyubiquitination, protein ubiquitination, regulation of apoptotic process, regulation of cell cycle, ubiquitin-dependent protein catabolic process; MF: identical protein binding, protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: SCF ubiquitin ligase complex, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: C-MYC pathway, Cell cycle, Cell cycle - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), FOXM1 transcription factor network, FoxO family signaling, FoxO signaling pathway - Homo sapiens (human), Imatinib and Chronic Myeloid Leukemia, Notch, Notch signaling pathway, Pathways in cancer - Homo sapiens (human), Regulation of retinoblastoma protein, Retinoblastoma gene in cancer, Small cell lung cancer - Homo sapiens (human), Ubiquitin mediated proteolysis - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), e2f1 destruction pathway, mTOR signaling pathway - Homo sapiens (human), p53 pathway, regulation of p27 phosphorylation during cell cycle progression
UniProt: Q13309
Entrez ID: 6502
|
Does Knockout of HK2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
HK2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: HK2 (hexokinase 2)
Type: protein-coding
Summary: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009].
Gene Ontology: BP: apoptotic mitochondrial changes, canonical glycolysis, carbohydrate derivative metabolic process, carbohydrate metabolic process, carbohydrate phosphorylation, cellular response to leukemia inhibitory factor, establishment of protein localization to mitochondrion, fructose 6-phosphate metabolic process, glucose 6-phosphate metabolic process, glucose metabolic process, glycolytic process, hexose metabolic process, intracellular glucose homeostasis, lactation, maintenance of protein location in mitochondrion, negative regulation of mitochondrial membrane permeability, negative regulation of reactive oxygen species metabolic process, organophosphate metabolic process, positive regulation of angiogenesis, positive regulation of type 2 mitophagy, regulation of D-glucose import, response to hypoxia, response to ischemia; MF: ATP binding, D-glucose binding, catalytic activity, fructokinase activity, glucokinase activity, hexokinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein binding, transferase activity; CC: centrosome, cytoplasm, cytosol, membrane, mitochondrial outer membrane, mitochondrion, sarcoplasmic reticulum
Pathways: Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Carbohydrate digestion and absorption - Homo sapiens (human), Central carbon metabolism in cancer - Homo sapiens (human), Fanconi-bickel syndrome, Fructose and mannose metabolism - Homo sapiens (human), Fructose-1,6-diphosphatase deficiency, GDP-glucose biosynthesis II, Galactose metabolism - Homo sapiens (human), Gluconeogenesis, Glucose metabolism, Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogen synthetase deficiency, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycogenosis, Type III. Cori disease, Debrancher glycogenosis, Glycogenosis, Type IV. Amylopectinosis, Anderson disease, Glycogenosis, Type VI. Hers disease, Glycogenosis, Type VII. Tarui disease, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, HIF-1 signaling pathway - Homo sapiens (human), HIF-1-alpha transcription factor network, Insulin signaling pathway - Homo sapiens (human), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Mucopolysaccharidosis VI. Sly syndrome, Neomycin, kanamycin and gentamicin biosynthesis - Homo sapiens (human), Pathways in clear cell renal cell carcinoma, Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Shigellosis - Homo sapiens (human), Starch and Sucrose Metabolism, Starch and sucrose metabolism - Homo sapiens (human), Sucrase-isomaltase deficiency, Triosephosphate isomerase, Type II diabetes mellitus - Homo sapiens (human), Warburg Effect, glycolysis, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P52789
Entrez ID: 3099
|
Does Knockout of RPL18A in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
RPL18A
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RPL18A (ribosomal protein L18a)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, postsynaptic density, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, VEGFA-VEGFR2 Signaling Pathway, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q02543
Entrez ID: 6142
|
Does Knockout of SPOUT1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
SPOUT1
|
response to virus
|
Hepatoma Cell Line
|
Gene: SPOUT1 (SPOUT domain containing methyltransferase 1)
Type: protein-coding
Summary: Enables miRNA binding activity. Involved in maintenance of centrosome location and production of miRNAs involved in gene silencing by miRNA. Located in kinetochore; mitotic spindle; and spindle pole centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, maintenance of centrosome location, methylation, miRNA processing, post-transcriptional regulation of gene expression, rRNA base methylation, rRNA processing; MF: RNA binding, S-adenosyl-L-methionine binding, methyltransferase activity, miRNA binding, protein binding, rRNA (uridine-N3-)-methyltransferase activity, transferase activity; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, kinetochore, mitotic spindle, spindle, spindle pole centrosome
Pathways:
UniProt: Q5T280
Entrez ID: 51490
|
Does Activation of PAIP2B in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
PAIP2B
|
response to virus
|
Hepatoma Cell Line
|
Gene: PAIP2B (poly(A) binding protein interacting protein 2B)
Type: protein-coding
Summary: Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: negative regulation of translation, negative regulation of translational initiation, regulation of translation; MF: mRNA regulatory element binding translation repressor activity, protein binding, translation repressor activity; CC: cytoplasm
Pathways:
UniProt: Q9ULR5
Entrez ID: 400961
|
Does Knockout of RPL37 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
RPL37
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RPL37 (ribosomal protein L37)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, positive regulation of signal transduction by p53 class mediator, translation; MF: MDM2/MDM4 family protein binding, RNA binding, metal ion binding, rRNA binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity, zinc ion binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P61927
Entrez ID: 6167
|
Does Knockout of SNRNP70 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
SNRNP70
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70)
Type: protein-coding
Summary: Enables U1 snRNA binding activity. Involved in mRNA splicing, via spliceosome and regulation of RNA splicing. Located in nucleoplasm. Part of U1 snRNP and spliceosomal complex. Implicated in disease of mental health and systemic lupus erythematosus. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, mRNA processing, mRNA splicing, via spliceosome, negative regulation of chaperone-mediated autophagy, negative regulation of protein refolding, positive regulation of mRNA splicing, via spliceosome, regulation of RNA splicing; MF: RNA binding, U1 snRNA binding, U1 snRNP binding, mRNA binding, nucleic acid binding, protein binding; CC: U1 snRNP, U2-type prespliceosome, lysosomal lumen, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), TCR, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, spliceosomal assembly
UniProt: P08621
Entrez ID: 6625
|
Does Knockout of DHDDS in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
DHDDS
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DHDDS (dehydrodolichyl diphosphate synthase subunit)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: dolichyl diphosphate biosynthetic process, dolichyl monophosphate biosynthetic process, lipid metabolic process, polyprenol biosynthetic process, protein glycosylation; MF: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity, metal ion binding, prenyltransferase activity, protein binding, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: dehydrodolichyl diphosphate synthase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective DHDDS causes RP59, Disease, Diseases associated with glycosylation precursor biosynthesis, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, Post-translational protein modification, Synthesis of dolichyl-phosphate, Synthesis of substrates in N-glycan biosythesis, Terpenoid backbone biosynthesis - Homo sapiens (human), dolichol and dolichyl phosphate biosynthesis
UniProt: Q86SQ9
Entrez ID: 79947
|
Does Knockout of DDC in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
DDC
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: DDC (dopa decarboxylase)
Type: protein-coding
Summary: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: amino acid metabolic process, biogenic amine biosynthetic process, carboxylic acid metabolic process, catecholamine biosynthetic process, catecholamine metabolic process, dopamine biosynthetic process, gene expression, kidney development, response to toxic substance, serotonin biosynthetic process; MF: 5-hydroxy-L-tryptophan decarboxylase activity, L-dopa decarboxylase activity, aromatic-L-amino-acid decarboxylase activity, carbon-carbon lyase activity, carboxy-lyase activity, enzyme binding, lyase activity, protein binding, pyridoxal phosphate binding; CC: cytoplasm, cytosol, extracellular exosome
Pathways: Alcoholism - Homo sapiens (human), Alkaptonuria, Amino Acid metabolism, Amphetamine addiction - Homo sapiens (human), AndrogenReceptor, Aromatic L-Aminoacid Decarboxylase Deficiency, Biogenic Amine Synthesis, Catecholamine Biosynthesis, Catecholamine biosynthesis, Cocaine addiction - Homo sapiens (human), Disulfiram Action Pathway, Dopamine beta-hydroxylase deficiency, Dopamine metabolism, Dopaminergic Neurogenesis, Dopaminergic synapse - Homo sapiens (human), Hawkinsinuria, Metabolism, Metabolism of amine-derived hormones, Metabolism of amino acids and derivatives, Monoamine oxidase-a deficiency (MAO-A), Nicotine Activity on Dopaminergic Neurons, Parkinson,s disease pathway, Phenylalanine metabolism - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Serotonin and melatonin biosynthesis, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Tryptophan Metabolism, Tryptophan metabolism, Tryptophan metabolism - Homo sapiens (human), Tyrosine Metabolism, Tyrosine hydroxylase deficiency, Tyrosine metabolism - Homo sapiens (human), Tyrosinemia Type I, Tyrosinemia, transient, of the newborn, catecholamine biosynthesis, serotonin and melatonin biosynthesis, superpathway of tryptophan utilization, tryptophan degradation X (mammalian, via tryptamine)
UniProt: P20711
Entrez ID: 1644
|
Does Knockout of RBM17 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
RBM17
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RBM17 (RNA binding motif protein 17)
Type: protein-coding
Summary: This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, alternative mRNA splicing, via spliceosome, mRNA cis splicing, via spliceosome, mRNA processing; MF: RNA binding, nucleic acid binding, protein binding; CC: nucleoplasm, nucleus, protein-containing complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q96I25
Entrez ID: 84991
|
Does Knockout of SUMO1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
SUMO1
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: SUMO1 (small ubiquitin like modifier 1)
Type: protein-coding
Summary: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA repair, PML body organization, cellular response to cadmium ion, cellular response to heat, negative regulation of DNA binding, negative regulation of DNA-binding transcription factor activity, negative regulation of DNA-templated transcription, negative regulation of action potential, negative regulation of delayed rectifier potassium channel activity, negative regulation of potassium ion transmembrane transporter activity, negative regulation of protein import into nucleus, negative regulation of transcription by RNA polymerase II, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein-containing complex assembly, protein localization to nuclear pore, protein stabilization, protein sumoylation, regulation of DNA-templated transcription, regulation of calcium ion transmembrane transport, regulation of cardiac muscle cell contraction, regulation of protein localization, regulation of protein stability, roof of mouth development; MF: RNA binding, enzyme binding, potassium channel regulator activity, protein binding, protein tag activity, small protein activating enzyme binding, transcription factor binding, transporter activator activity, ubiquitin protein ligase binding, ubiquitin-like protein ligase binding, ubiquitin-specific protease binding; CC: PML body, XY body, cytoplasm, cytosol, glutamatergic synapse, membrane, nuclear body, nuclear membrane, nuclear pore, nuclear speck, nuclear stress granule, nucleolus, nucleoplasm, nucleus, plasma membrane, postsynaptic cytosol, presynaptic cytosol, voltage-gated potassium channel complex
Pathways: Androgen receptor signaling pathway, Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cytokine Signaling in Immune system, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Developmental Biology, Disease, Exercise-induced Circadian Regulation, Fluid shear stress and atherosclerosis - Homo sapiens (human), Formation of Incision Complex in GG-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Immune System, Infectious disease, Interferon Signaling, Interferon gamma signaling, Late SARS-CoV-2 Infection Events, M Phase, MITF-M-regulated melanocyte development, Maturation of nucleoprotein, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Negative regulation of activity of TFAP2 (AP-2) family transcription factors, Nuclear Envelope (NE) Reassembly, Nucleotide Excision Repair, PKR-mediated signaling, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing and activation of SUMO, RNA Polymerase II Transcription, RNA transport - Homo sapiens (human), Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of IFNG signaling, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, SUMO E3 ligases SUMOylate target proteins, SUMO is conjugated to E1 (UBA2:SAE1), SUMO is proteolytically processed, SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA methylation proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of immune response proteins, SUMOylation of intracellular receptors, SUMOylation of nuclear envelope proteins, SUMOylation of transcription cofactors, SUMOylation of transcription factors, SUMOylation of ubiquitinylation proteins, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TGF-beta Signaling Pathway, TGF_beta_Receptor, TNFalpha, TP53 network, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Translation of Structural Proteins, Viral Infection Pathways, basic mechanisms of sumoylation, regulation of transcriptional activity by pml, role of parkin in ubiquitin-proteasomal pathway, sumoylation as a mechanism to modulate ctbp-dependent gene responses, sumoylation by ranbp2 regulates transcriptional repression
UniProt: P63165
Entrez ID: 7341
|
Does Knockout of SCX in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
SCX
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: SCX (scleraxis bHLH transcription factor)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and bHLH transcription factor binding activity. Contributes to E-box binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: BMP signaling pathway, DNA-templated transcription, Sertoli cell development, Sertoli cell differentiation, cell differentiation, cellular response to BMP stimulus, cellular response to cAMP, cellular response to follicle-stimulating hormone stimulus, cellular response to mechanical stimulus, cellular response to transforming growth factor beta stimulus, chondrocyte differentiation, collagen fibril organization, deltoid tuberosity development, developmental process, embryonic skeletal system development, endochondral ossification, face morphogenesis, heart valve formation, heart valve morphogenesis, mesoderm formation, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of gene expression, positive regulation of DNA-templated transcription, positive regulation of cartilage development, positive regulation of cell population proliferation, positive regulation of collagen biosynthetic process, positive regulation of gastrulation, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of cartilage development, regulation of transcription by RNA polymerase II, sclerotome development, skeletal muscle cell differentiation, tendon cell differentiation, tendon development, tendon formation, tissue homeostasis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, bHLH transcription factor binding, cis-regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity, sequence-specific DNA binding; CC: chromatin, nucleus, transcription regulator complex
Pathways:
UniProt: Q7RTU7
Entrez ID: 642658
|
Does Knockout of MRPL13 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
MRPL13
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MRPL13 (mitochondrial ribosomal protein L13)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, negative regulation of translation, translation; MF: RNA binding, mRNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9BYD1
Entrez ID: 28998
|
Does Knockout of NDUFS3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
NDUFS3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: NDUFS3 (NADH:ubiquinone oxidoreductase core subunit S3)
Type: protein-coding
Summary: This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009].
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport, reactive oxygen species metabolic process, substantia nigra development; MF: NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, electron transfer activity, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, nuclear body, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Doxorubicin Metabolism Pathway, Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), RHO GTPase cycle, RHOG GTPase cycle, Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Thermogenesis - Homo sapiens (human), cardiolipin biosynthesis
UniProt: O75489
Entrez ID: 4722
|
Does Knockout of FIGN in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
FIGN
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: FIGN (fidgetin, microtubule severing factor)
Type: protein-coding
Summary: Predicted to enable microtubule-severing ATPase activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to act upstream of or within locomotory behavior. Predicted to be located in nuclear matrix. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, microtubule severing; MF: ATP binding, ATP hydrolysis activity, microtubule severing ATPase activity, nucleotide binding, protein binding; CC: centrosome, cytoplasm, cytoskeleton, microtubule, nuclear matrix, nucleus
Pathways:
UniProt: Q5HY92
Entrez ID: 55137
|
Does Activation of FSIP2 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
FSIP2
|
response to virus
|
Hepatoma Cell Line
|
Gene: FSIP2 (fibrous sheath interacting protein 2)
Type: protein-coding
Summary: This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: flagellated sperm motility, protein localization to cilium, sperm axoneme assembly; CC: sperm end piece, sperm head-tail coupling apparatus, sperm midpiece, sperm principal piece
Pathways:
UniProt: Q5CZC0
Entrez ID: 401024
|
Does Knockout of CRH in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
CRH
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: CRH (corticotropin releasing hormone)
Type: protein-coding
Summary: This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: adrenal gland development, associative learning, cellular response to cocaine, cellular response to dexamethasone stimulus, chemical synaptic transmission, diterpenoid metabolic process, female pregnancy, glucocorticoid biosynthetic process, hormone-mediated apoptotic signaling pathway, hypothalamus development, inflammatory response, learning or memory, locomotory exploration behavior, long-term synaptic potentiation, lung development, monoatomic ion homeostasis, negative regulation of circadian sleep/wake cycle, REM sleep, negative regulation of epinephrine secretion, negative regulation of gene expression, negative regulation of glucagon secretion, negative regulation of luteinizing hormone secretion, negative regulation of norepinephrine secretion, negative regulation of systemic arterial blood pressure, neuron apoptotic process, parturition, positive regulation of behavioral fear response, positive regulation of cAMP/PKA signal transduction, positive regulation of calcium ion import, positive regulation of cell population proliferation, positive regulation of circadian sleep/wake cycle, wakefulness, positive regulation of corticosterone secretion, positive regulation of corticotropin secretion, positive regulation of cortisol secretion, positive regulation of digestive system process, positive regulation of gene expression, positive regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of NMDA receptor activity, regulation of serotonin secretion, response to alcohol, response to aldosterone, response to cocaine, response to corticosterone, response to estrogen, response to ethanol, response to ether, response to immobilization stress, response to pain, response to xenobiotic stimulus, signal transduction, steroid metabolic process, synaptic transmission, dopaminergic; MF: corticotropin-releasing hormone activity, corticotropin-releasing hormone receptor 1 binding, corticotropin-releasing hormone receptor 2 binding, hormone activity, neuropeptide hormone activity, protein binding, signaling receptor binding; CC: extracellular region, extracellular space, neuronal cell body, neuronal dense core vesicle lumen, perikaryon, synapse, varicosity
Pathways: Alcoholism - Homo sapiens (human), CRH, Class B/2 (Secretin family receptors), Corticotropin-releasing hormone signaling pathway, Cushing syndrome - Homo sapiens (human), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Gene expression (Transcription), Generic Transcription Pathway, Long-term depression - Homo sapiens (human), MECP2 regulates transcription of neuronal ligands, Myometrial relaxation and contraction pathways, Neuroactive ligand-receptor interaction - Homo sapiens (human), RNA Polymerase II Transcription, Serotonin and anxiety, Serotonin and anxiety-related events, Signal Transduction, Signaling by GPCR, Transcriptional Regulation by MECP2
UniProt: P06850
Entrez ID: 1392
|
Does Knockout of DMRT3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
DMRT3
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: DMRT3 (doublesex and mab-3 related transcription factor 3)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in male sex differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult walking behavior; transmission of nerve impulse; and ventral spinal cord interneuron specification. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: adult locomotory behavior, adult walking behavior, cell differentiation, male sex differentiation, regulation of DNA-templated transcription, regulation of odontogenesis of dentin-containing tooth, regulation of transcription by RNA polymerase II, sex differentiation, transmission of nerve impulse, ventral spinal cord interneuron specification; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: Q9NQL9
Entrez ID: 58524
|
Does Knockout of ZBTB7A in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
ZBTB7A
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: ZBTB7A (zinc finger and BTB domain containing 7A)
Type: protein-coding
Summary: Enables several functions, including SMAD binding activity; androgen receptor binding activity; and transcription corepressor binding activity. Involved in several processes, including erythrocyte maturation; negative regulation of signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Colocalizes with DNA-dependent protein kinase complex and NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: B cell differentiation, DNA-templated transcription, cell differentiation, chromatin organization, chromatin remodeling, double-strand break repair via classical nonhomologous end joining, erythrocyte maturation, fat cell differentiation, negative regulation of DNA-templated transcription, negative regulation of Notch signaling pathway, negative regulation of androgen receptor signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of NF-kappaB transcription factor activity, protein localization to nucleus, regulation of DNA-binding transcription factor activity, regulation of alternative mRNA splicing, via spliceosome, regulation of apoptotic process, regulation of glycolytic process, regulation of transcription by RNA polymerase II, regulation of transcription regulatory region DNA binding; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SMAD binding, histone acetyltransferase binding, metal ion binding, nuclear androgen receptor binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription corepressor binding, zinc ion binding; CC: DNA-dependent protein kinase complex, cytoplasm, nucleus, site of double-strand break
Pathways: IL-18 signaling pathway, b cell survival pathway
UniProt: O95365
Entrez ID: 51341
|
Does Knockout of REXO1L1P in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
REXO1L1P
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: REXO1L1P (REXO1 like 1, pseudogene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of RPS27 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
RPS27
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: RPS27 (ribosomal protein S27)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2018].
Gene Ontology: BP: cytoplasmic translation, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, translation; MF: DNA binding, RNA binding, metal ion binding, protein binding, structural constituent of ribosome, zinc ion binding; CC: GABA-ergic synapse, cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, glutamatergic synapse, nucleolus, nucleoplasm, nucleus, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Axon guidance, Cap-dependent Translation Initiation, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, EML4 and NUDC in mitotic spindle formation, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Genotoxicity pathway, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, M Phase, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of expression of SLITs and ROBOs, Resolution of Sister Chromatid Cohesion, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Separation of Sister Chromatids, Signal Transduction, Signaling by ROBO receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P42677
Entrez ID: 6232
|
Does Knockout of MED25 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
MED25
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: MED25 (mediator complex subunit 25)
Type: protein-coding
Summary: This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, negative regulation of fibroblast proliferation, negative regulation of transcription by RNA polymerase II, positive regulation of chromatin binding, positive regulation of mediator complex assembly, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II; MF: nuclear retinoic acid receptor binding, nuclear retinoid X receptor binding, protein binding, transcription coactivator binding; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Adipogenesis, Developmental Biology, Disease, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q71SY5
Entrez ID: 81857
|
Does Knockout of MFSD6 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
MFSD6
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MFSD6 (major facilitator superfamily domain containing 6)
Type: protein-coding
Summary: Predicted to enable MHC class I protein binding activity and MHC class I receptor activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class I. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q6ZSS7
Entrez ID: 54842
|
Does Knockout of SPART in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
SPART
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: SPART (spartin)
Type: protein-coding
Summary: This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008].
Gene Ontology: BP: BMP signaling pathway, adipose tissue development, cell division, collateral sprouting in absence of injury, lipid catabolic process, lipid droplet organization, lipid metabolic process, lipid transport, lipophagy, midbody abscission, negative regulation of BMP signaling pathway, negative regulation of collateral sprouting in absence of injury, neuromuscular process, regulation of biological quality, regulation of mitochondrial membrane potential; MF: lipid binding, protein binding, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, lipid droplet, midbody, mitochondrial outer membrane, plasma membrane, synapse
Pathways: EGFR1, Endocytosis - Homo sapiens (human)
UniProt: Q8N0X7
Entrez ID: 23111
|
Does Knockout of OR10T2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
OR10T2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: OR10T2 (olfactory receptor family 10 subfamily T member 2)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGX3
Entrez ID: 128360
|
Does Knockout of FUCA1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
FUCA1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: FUCA1 (alpha-L-fucosidase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: carbohydrate metabolic process, fucose metabolic process, glycolipid catabolic process, glycoside catabolic process, lipid metabolic process; MF: alpha-L-fucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, protein binding; CC: azurophil granule lumen, cytoplasm, extracellular exosome, extracellular region, lysosomal lumen, lysosome, membrane
Pathways: Asparagine N-linked glycosylation, Immune System, Innate Immune System, Lysosome - Homo sapiens (human), Metabolism of proteins, N-glycan antennae elongation in the medial/trans-Golgi, Neutrophil degranulation, Other glycan degradation - Homo sapiens (human), Post-translational protein modification, Reactions specific to the complex N-glycan synthesis pathway, Transport to the Golgi and subsequent modification, p53 transcriptional gene network
UniProt: P04066
Entrez ID: 2517
|
Does Knockout of CNRIP1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
CNRIP1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: CNRIP1 (cannabinoid receptor interacting protein 1)
Type: protein-coding
Summary: This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: negative regulation of signaling receptor activity, regulation of signaling receptor activity, regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission; MF: protein binding, type 1 cannabinoid receptor binding; CC: GABA-ergic synapse, cytoplasm, glutamatergic synapse, plasma membrane, presynapse
Pathways:
UniProt: Q96F85
Entrez ID: 25927
|
Does Knockout of SLC25A37 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
SLC25A37
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: SLC25A37 (solute carrier family 25 member 37)
Type: protein-coding
Summary: SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011].
Gene Ontology: BP: iron import into the mitochondrion, iron ion transport, monoatomic ion transport, positive regulation of hemoglobin biosynthetic process; MF: ferrous iron transmembrane transporter activity, iron ion transmembrane transporter activity, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways: Metabolism, Mitochondrial iron-sulfur cluster biogenesis
UniProt: Q9NYZ2
Entrez ID: 51312
|
Does Knockout of COL11A2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
COL11A2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: COL11A2 (collagen type XI alpha 2 chain)
Type: protein-coding
Summary: This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: cartilage development, collagen fibril organization, roof of mouth development, sensory perception of sound, skeletal system development, soft palate development; MF: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, metal ion binding, protein binding, protein-macromolecule adaptor activity; CC: collagen trimer, collagen type II trimer, collagen type XI trimer, endoplasmic reticulum lumen, extracellular matrix, extracellular region
Pathways: Assembly of collagen fibrils and other multimeric structures, Beta1 integrin cell surface interactions, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Pancreatic Ductal Cells, Extracellular matrix organization, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Integrins in angiogenesis, MET activates PTK2 signaling, MET promotes cell motility, Neural Crest Differentiation, Non-integrin membrane-ECM interactions, Protein digestion and absorption - Homo sapiens (human), Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Syndecan-1-mediated signaling events
UniProt: P13942
Entrez ID: 1302
|
Does Knockout of DMRT1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
DMRT1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DMRT1 (doublesex and mab-3 related transcription factor 1)
Type: protein-coding
Summary: This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Sertoli cell development, Sertoli cell differentiation, cell differentiation, cell morphogenesis, developmental process involved in reproduction, germ cell migration, intracellular signal transduction, male germ cell proliferation, male gonad development, male sex determination, male sex differentiation, meiosis I, negative regulation of meiotic nuclear division, negative regulation of transcription by RNA polymerase II, oocyte development, positive regulation of male gonad development, positive regulation of meiosis I, positive regulation of mitotic nuclear division, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of nodal signaling pathway, regulation of transcription by RNA polymerase II, sex differentiation, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytoplasm, female germ cell nucleus, nucleus
Pathways: Developmental Biology, Mammalian disorder of sexual development, Somatic sex determination, Transcriptional regulation of testis differentiation
UniProt: Q9Y5R6
Entrez ID: 1761
|
Does Knockout of SNRNP40 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
SNRNP40
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: SNRNP40 (small nuclear ribonucleoprotein U5 subunit 40)
Type: protein-coding
Summary: This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA processing, RNA splicing, RNA splicing, via transesterification reactions, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: U2-type catalytic step 2 spliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, cytosol, nuclear speck, nucleoplasm, nucleus, sno(s)RNA-containing ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q96DI7
Entrez ID: 9410
|
Does Knockout of UBA2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
UBA2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: UBA2 (ubiquitin like modifier activating enzyme 2)
Type: protein-coding
Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010].
Gene Ontology: BP: positive regulation of protein sumoylation, protein sumoylation; MF: ATP binding, SUMO activating enzyme activity, SUMO binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein heterodimerization activity, small protein activating enzyme binding, transferase activity, ubiquitin-like modifier activating enzyme activity, ubiquitin-like protein conjugating enzyme binding; CC: SUMO activating enzyme complex, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, SUMO is conjugated to E1 (UBA2:SAE1), SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, Ubiquitin mediated proteolysis - Homo sapiens (human), basic mechanisms of sumoylation
UniProt: Q9UBT2
Entrez ID: 10054
|
Does Knockout of RPL18 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
RPL18
|
cell proliferation
|
Cancer Cell Line
|
Gene: RPL18 (ribosomal protein L18)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, focal adhesion, membrane, nucleolus, nucleus, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q07020
Entrez ID: 6141
|
Does Knockout of SNAPC4 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
SNAPC4
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: SNAPC4 (small nuclear RNA activating complex polypeptide 4)
Type: protein-coding
Summary: This gene encodes the largest subunit of the small nuclear RNA-activating protein (SNAP) complex. The encoded protein contains a Myb DNA-binding domain, and is essential for RNA polymerase II and III polymerase transcription from small nuclear RNA promoters. A mutation in this gene is associated with ankylosing spondylitis. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III; MF: DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase III general transcription initiation factor activity, RNA polymerase III type 3 promoter sequence-specific DNA binding, protein binding; CC: nucleoplasm, nucleus, snRNA-activating protein complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes
UniProt: Q5SXM2
Entrez ID: 6621
|
Does Knockout of RPL34 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
RPL34
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RPL34 (ribosomal protein L34)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, cadherin binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, extracellular exosome, nucleolus, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P49207
Entrez ID: 6164
|
Does Knockout of RBX1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
RBX1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: RBX1 (ring-box 1)
Type: protein-coding
Summary: This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010].
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, G1/S transition of mitotic cell cycle, MAPK cascade, RNA polymerase II transcription initiation surveillance, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, T cell activation, TORC1 signaling, apoptotic process, autophagosome assembly, base-excision repair, AP site formation via deaminated base removal, cellular response to UV, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to chemical stress, cellular response to insulin stimulus, cellular response to nutrient levels, cellular response to oxidative stress, cytokine-mediated signaling pathway, epithelial to mesenchymal transition, insulin receptor signaling pathway, lysosome organization, miRNA-mediated gene silencing by mRNA destabilization, mitophagy, negative regulation of TORC1 signaling, negative regulation of autophagy, negative regulation of canonical NF-kappaB signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of insulin receptor signaling pathway, negative regulation of mitophagy, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of response to oxidative stress, negative regulation of signal transduction by p53 class mediator, negative regulation of type I interferon production, negative regulation of ubiquitin-dependent protein catabolic process, p38MAPK cascade, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of epithelial cell apoptotic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein autoubiquitination, positive regulation of protein catabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of translation, positive regulation of type I interferon production, post-translational protein modification, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein catabolic process, protein monoubiquitination, protein neddylation, protein polyubiquitination, protein ubiquitination, regulation of cellular response to insulin stimulus, regulation of mitotic cell cycle, renal sodium ion absorption, response to oxidative stress, signal transduction in response to DNA damage, spermatogenesis, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription-coupled nucleotide-excision repair, type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: NEDD8 ligase activity, NEDD8 transferase activity, RNA polymerase II-specific DNA-binding transcription factor binding, cullin family protein binding, metal ion binding, molecular adaptor activity, protein binding, protein-containing complex binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, zinc ion binding; CC: Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, Cul5-RING ubiquitin ligase complex, Cul7-RING ubiquitin ligase complex, SCF ubiquitin ligase complex, VCB complex, cullin-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus, site of DNA damage
Pathways: 22q11.2 copy number variation syndrome, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Axon guidance, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Circadian rhythm - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Cytokine Signaling in Immune system, DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dual Incision in GG-NER, Dual hijack model of Vif in HIV infection, Dual incision in TC-NER, Evasion by RSV of host interferon responses, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FBXW7 Mutants and NOTCH1 in Cancer, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, G1/S DNA Damage Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIF-1 signaling pathway - Homo sapiens (human), HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hijack of ubiquitination by SARS-CoV-2, Hippo-Merlin Signaling Dysregulation, Host Interactions of HIV factors, Human immunodeficiency virus 1 infection - Homo sapiens (human), Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, Immune System, Infectious disease, Interleukin-1 family signaling, Interleukin-1 signaling, KEAP1-NFE2L2 pathway, Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Metabolism of proteins, Mitotic G2-G2/M phases, NOTCH1 Intracellular Domain Regulates Transcription, NRF2-ARE regulation, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Notch, Nuclear events mediated by NFE2L2, Nuclear events stimulated by ALK signaling in cancer, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Pathways in cancer - Homo sapiens (human), Post-translational protein modification, Potential therapeutics for SARS, Prolactin receptor signaling, Protein processing in endoplasmic reticulum - Homo sapiens (human), RAF/MAP kinase cascade, RNA Polymerase II Transcription, RSV-host interactions, Recognition of DNA damage by PCNA-containing replication complex, Regulation of BACH1 activity, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of T cell activation by CD28 family, Regulation of expression of SLITs and ROBOs, Renal cell carcinoma - Homo sapiens (human), Respiratory Syncytial Virus Infection Pathway, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SARS-CoV Infections, SPOP-mediated proteasomal degradation of PD-L1(CD274), Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TGF-beta Signaling Pathway, TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional regulation by RUNX2, Translation, Type 2 papillary renal cell carcinoma, Ubiquitin mediated proteolysis - Homo sapiens (human), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Wnt signaling pathway - Homo sapiens (human), er associated degradation (erad) pathway, p53-Independent G1/S DNA Damage Checkpoint, regulation of p27 phosphorylation during cell cycle progression
UniProt: P62877
Entrez ID: 9978
|
Does Knockout of PELO in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
PELO
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PELO (pelota mRNA surveillance and ribosome rescue factor)
Type: protein-coding
Summary: This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA surveillance, cell division, chromosome organization, endoderm development, inner cell mass cell proliferation, mesenchymal to epithelial transition, nonfunctional rRNA decay, nuclear-transcribed mRNA catabolic process, no-go decay, nuclear-transcribed mRNA catabolic process, non-stop decay, positive regulation of BMP signaling pathway, regulation of translation, rescue of stalled ribosome, ribosome disassembly, stem cell population maintenance; MF: metal ion binding, nucleoside-triphosphatase regulator activity, protein binding, ribosome binding, stalled ribosome sensor activity; CC: Dom34-Hbs1 complex, cytoplasm, cytosolic ribosome
Pathways: Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Metabolism of proteins, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome-associated quality control, Translation, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9BRX2
Entrez ID: 53918
|
Does Knockout of NR4A2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
NR4A2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NR4A2 (nuclear receptor subfamily 4 group A member 2)
Type: protein-coding
Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, adult locomotory behavior, canonical Wnt signaling pathway, cellular response to corticotropin-releasing hormone stimulus, cellular response to oxidative stress, central nervous system neuron differentiation, central nervous system projection neuron axonogenesis, dopamine biosynthetic process, dopamine metabolic process, dopaminergic neuron differentiation, fat cell differentiation, gene expression, general adaptation syndrome, habenula development, intracellular receptor signaling pathway, midbrain dopaminergic neuron differentiation, negative regulation of apoptotic signaling pathway, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, nervous system development, neuron apoptotic process, neuron maturation, neuron migration, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, post-embryonic development, regulation of DNA-templated transcription, regulation of dopamine metabolic process, regulation of gene expression, regulation of respiratory gaseous exchange, regulation of transcription by RNA polymerase II, response to amphetamine, response to hypoxia, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, beta-catenin binding, metal ion binding, nuclear glucocorticoid receptor binding, nuclear receptor activity, nuclear retinoid X receptor binding, protein binding, protein heterodimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromatin, cytoplasm, nuclear speck, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: Aldosterone synthesis and secretion - Homo sapiens (human), Corticotropin-releasing hormone signaling pathway, Dopaminergic Neurogenesis, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Nuclear Receptor transcription pathway, Nuclear receptors, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of intracellular receptors, VEGFA-VEGFR2 Signaling Pathway
UniProt: P43354
Entrez ID: 4929
|
Does Knockout of CELSR3 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
CELSR3
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3)
Type: protein-coding
Summary: This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Wnt signaling pathway, planar cell polarity pathway, axonogenesis, cell adhesion, cell surface receptor signaling pathway, cell-cell adhesion mediated by cadherin, dopaminergic neuron axon guidance, homophilic cell adhesion via plasma membrane adhesion molecules, serotonergic neuron axon guidance, signal transduction; MF: G protein-coupled receptor activity, calcium ion binding, protein binding, transmembrane signaling receptor activity; CC: adherens junction, membrane, plasma membrane
Pathways: GPCRs, Other
UniProt: Q9NYQ7
Entrez ID: 1951
|
Does Knockout of GLRX in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
GLRX
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: GLRX (glutaredoxin)
Type: protein-coding
Summary: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: nucleobase-containing small molecule interconversion, positive regulation of membrane potential; MF: disulfide oxidoreductase activity, glutathione disulfide oxidoreductase activity, protein binding, sodium channel regulator activity; CC: cytoplasm, cytosol, extracellular exosome, nucleus
Pathways: Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, One-carbon metabolism, arsenate detoxification I (glutaredoxin), ascorbate recycling (cytosolic), glutathione redox reactions II
UniProt: P35754
Entrez ID: 2745
|
Does Knockout of DYNC1H1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
DYNC1H1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Type: protein-coding
Summary: Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: P-body assembly, cell division, cytoplasmic microtubule organization, establishment of spindle localization, microtubule-based movement, mitotic spindle organization, nuclear migration, positive regulation of cold-induced thermogenesis, positive regulation of intracellular transport, positive regulation of spindle assembly, regulation of metaphase plate congression, regulation of mitotic spindle organization, retrograde axonal transport, stress granule assembly; MF: ATP binding, RNA binding, dynein intermediate chain binding, dynein light intermediate chain binding, identical protein binding, minus-end-directed microtubule motor activity, nucleotide binding, protein binding; CC: axon cytoplasm, azurophil granule lumen, cell cortex, centrosome, cytoplasm, cytoplasmic dynein complex, cytoplasmic microtubule, cytoskeleton, cytosol, dynein complex, extracellular exosome, extracellular region, filopodium, membrane, microtubule
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Aggrephagy, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, Autophagy, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Ciliary landscape, Cilium Assembly, Disease, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HCMV Early Events, HCMV Infection, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Immune System, Infectious disease, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport proteins binding to dynein, Lissencephaly gene (LIS1) in neuronal migration and development, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Neutrophil degranulation, Organelle biogenesis and maintenance, Phagosome - Homo sapiens (human), Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Salmonella infection - Homo sapiens (human), Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q14204
Entrez ID: 1778
|
Does Knockout of AIFM2 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
AIFM2
|
cell proliferation
|
Bladder Carcinoma
|
Gene: AIFM2 (AIF family member 2)
Type: protein-coding
Summary: This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: apoptotic mitochondrial changes, cellular detoxification, negative regulation of ferroptosis, positive regulation of apoptotic process, regulation of cellular response to oxidative stress, respiratory electron transport chain, ubiquinone metabolic process, vitamin K metabolic process; MF: DNA binding, electron-transferring-flavoprotein dehydrogenase activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, protein binding; CC: cytoplasm, cytosol, extracellular space, lipid droplet, membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, nucleus, plasma membrane
Pathways: Apoptosis Modulation and Signaling, Direct p53 effectors, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53, p53 signaling pathway - Homo sapiens (human)
UniProt: Q9BRQ8
Entrez ID: 84883
|
Does Knockout of FRG2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
FRG2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: FRG2 (FSHD region gene 2)
Type: protein-coding
Summary: Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q64ET8
Entrez ID: 448831
|
Does Knockout of HMOX2 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
HMOX2
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: HMOX2 (heme oxygenase 2)
Type: protein-coding
Summary: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013].
Gene Ontology: BP: heme catabolic process, heme oxidation, response to hypoxia, response to oxidative stress; MF: heme binding, heme oxygenase (decyclizing) activity, metal ion binding, oxidoreductase activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane, specific granule membrane
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Heme degradation, Immune System, Innate Immune System, Iron uptake and transport, Metabolism, Metabolism of porphyrins, Mineral absorption - Homo sapiens (human), Neutrophil degranulation, Porphyrin and chlorophyll metabolism - Homo sapiens (human), RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport of small molecules, heme degradation, oxidative stress induced gene expression via nrf2
UniProt: P30519
Entrez ID: 3163
|
Does Knockout of TELO2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
TELO2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: TELO2 (telomere maintenance 2)
Type: protein-coding
Summary: This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009].
Gene Ontology: BP: 'de novo' cotranslational protein folding, positive regulation of DNA damage checkpoint, protein stabilization; MF: Hsp90 protein binding, molecular adaptor activity, protein binding, protein kinase binding, protein-containing complex binding, telomeric DNA binding; CC: TTT Hsp90 cochaperone complex, chromosome, chromosome, telomeric region, cytoplasm, cytosol, membrane, nuclear body, nucleus
Pathways: Fanconi anemia pathway - Homo sapiens (human), Fragile X Syndrome, mTOR signaling pathway - Homo sapiens (human)
UniProt: Q9Y4R8
Entrez ID: 9894
|
Does Knockout of ZMYND12 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
ZMYND12
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ZMYND12 (zinc finger MYND-type containing 12)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: flagellated sperm motility, sperm axoneme assembly; MF: metal ion binding, protein binding, zinc ion binding; CC: cell projection, cilium, motile cilium, sperm flagellum
Pathways:
UniProt: Q9H0C1
Entrez ID: 84217
|
Does Knockout of IFNA14 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
IFNA14
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: IFNA14 (interferon alpha 14)
Type: protein-coding
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, cellular response to virus, defense response, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, protein binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways: Autoimmune thyroid disease - Homo sapiens (human), Coronavirus disease - COVID-19 - Homo sapiens (human), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), DDX58/IFIH1-mediated induction of interferon-alpha/beta, Disease, Downstream signaling in naïve CD8+ T cells, Epstein-Barr virus infection - Homo sapiens (human), Evasion by RSV of host interferon responses, Factors involved in megakaryocyte development and platelet production, Hemostasis, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Infectious disease, Influenza A - Homo sapiens (human), Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, JAK-STAT signaling pathway - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Measles - Homo sapiens (human), NOD-like receptor signaling pathway - Homo sapiens (human), Natural killer cell mediated cytotoxicity - Homo sapiens (human), Necroptosis - Homo sapiens (human), Overview of interferons-mediated signaling pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), RIG-I-like receptor signaling pathway - Homo sapiens (human), RSV-host interactions, Regulation of IFNA/IFNB signaling, Regulation of toll-like receptor signaling pathway, Respiratory Syncytial Virus Infection Pathway, SARS coronavirus and innate immunity, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, TRAF6 mediated IRF7 activation, Toll-like Receptor Signaling Pathway, Toll-like receptor signaling pathway - Homo sapiens (human), Tuberculosis - Homo sapiens (human), Viral Infection Pathways
UniProt: P01570
Entrez ID: 3448
|
Does Knockout of DEFB105A in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
DEFB105A
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: DEFB105A (defensin beta 105A)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: defense response, defense response to bacterium, innate immune response
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q8NG35
Entrez ID: 245908
|
Does Knockout of HM13 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
HM13
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: HM13 (histocompatibility minor 13)
Type: protein-coding
Summary: The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to oxidative stress, in utero embryonic development, membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, membrane protein proteolysis, membrane protein proteolysis involved in retrograde protein transport, ER to cytosol, proteolysis, signal peptide processing; MF: aspartic endopeptidase activity, intramembrane cleaving, hydrolase activity, peptidase activity, protein binding, protein homodimerization activity, ubiquitin protein ligase binding; CC: Derlin-1 retrotranslocation complex, cell surface, cytoplasmic side of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, lumenal side of endoplasmic reticulum membrane, membrane, plasma membrane, rough endoplasmic reticulum
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Regulation of HMOX1 expression and activity
UniProt: Q8TCT9
Entrez ID: 81502
|
Does Knockout of SPTBN4 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
SPTBN4
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: SPTBN4 (spectrin beta, non-erythrocytic 4)
Type: protein-coding
Summary: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin cytoskeleton organization, actin filament capping, adult behavior, adult walking behavior, axonogenesis, cardiac conduction, central nervous system projection neuron axonogenesis, clustering of voltage-gated sodium channels, fertilization, intracellular protein localization, negative regulation of heart rate, neuromuscular junction development, neuromuscular process, positive regulation of multicellular organism growth, protein localization to plasma membrane, protein-containing complex assembly, regulation of sodium ion transport, sensory perception of sound, transmission of nerve impulse, vesicle-mediated transport; MF: actin binding, actin filament binding, ankyrin binding, cytoskeletal protein binding, cytoskeletal protein-membrane anchor activity, phosphatase binding, phospholipid binding, protein binding, spectrin binding, structural constituent of cytoskeleton; CC: PML body, actin filament, adherens junction, axon, axon hillock, axon initial segment, cell body fiber, cell cortex, cell junction, cell projection, cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, extracellular exosome, intercalated disc, juxtaparanode region of axon, membrane, neuronal cell body, node of Ranvier, nuclear matrix, paranode region of axon, plasma membrane, spectrin
Pathways: Asparagine N-linked glycosylation, Axon guidance, COPI-mediated anterograde transport, Developmental Biology, ER to Golgi Anterograde Transport, Interaction between L1 and Ankyrins, L1CAM interactions, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Membrane Trafficking, Metabolism of proteins, NCAM signaling for neurite out-growth, Nervous system development, Post-translational protein modification, RAF/MAP kinase cascade, Signal Transduction, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9H254
Entrez ID: 57731
|
Does Knockout of PRDX4 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
PRDX4
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: PRDX4 (peroxiredoxin 4)
Type: protein-coding
Summary: The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: I-kappaB phosphorylation, cell redox homeostasis, cellular oxidant detoxification, extracellular matrix organization, hydrogen peroxide catabolic process, male gonad development, negative regulation of male germ cell proliferation, protein maturation, reactive oxygen species metabolic process, response to oxidative stress, spermatogenesis; MF: antioxidant activity, identical protein binding, molecular adaptor activity, molecular sequestering activity, oxidoreductase activity, peroxidase activity, peroxiredoxin activity, protein binding, thioredoxin peroxidase activity, thioredoxin-dependent peroxiredoxin activity; CC: cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, nucleus, secretory granule lumen
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, Selenium Micronutrient Network
UniProt: Q13162
Entrez ID: 10549
|
Does Knockout of CCL1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
CCL1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: CCL1 (C-C motif chemokine ligand 1)
Type: protein-coding
Summary: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, chemokine-mediated signaling pathway, chemotaxis, eosinophil chemotaxis, immune response, inflammatory response, intracellular calcium ion homeostasis, killing of cells of another organism, positive regulation of cell migration, positive regulation of cytosolic calcium ion concentration, positive regulation of inflammatory response, positive regulation of interleukin-17 production, positive regulation of monocyte chemotaxis, signal transduction, viral process; MF: CCR chemokine receptor binding, chemokine activity, cytokine activity; CC: extracellular region, extracellular space
Pathways: Aryl Hydrocarbon Receptor Netpath, Chemokine receptors bind chemokines, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Homo sapiens (human), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, IL-18 signaling pathway, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: P22362
Entrez ID: 6346
|
Does Knockout of TPSG1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
TPSG1
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: TPSG1 (tryptase gamma 1)
Type: protein-coding
Summary: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular space, membrane, plasma membrane
Pathways:
UniProt: Q9NRR2
Entrez ID: 25823
|
Does Knockout of PARS2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
PARS2
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: PARS2 (prolyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: prolyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, proline-tRNA ligase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Metabolism of proteins, Mitochondrial tRNA aminoacylation, Translation, tRNA Aminoacylation, tRNA charging
UniProt: Q7L3T8
Entrez ID: 25973
|
Does Knockout of CKAP4 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
CKAP4
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CKAP4 (cytoskeleton associated protein 4)
Type: protein-coding
Summary: Enables RNA binding activity. Located in several cellular components, including lipid droplet; nuclear speck; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protein binding; CC: azurophil granule membrane, cytoplasm, cytoskeleton, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, extracellular exosome, lamellar body, lipid droplet, membrane, mitochondrion, nuclear speck, perinuclear region of cytoplasm, plasma membrane, rough endoplasmic reticulum, specific granule membrane
Pathways: Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, Post-translational protein phosphorylation, Protein processing in endoplasmic reticulum - Homo sapiens (human), RHO GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Surfactant metabolism
UniProt: Q07065
Entrez ID: 10970
|
Does Knockout of C5orf24 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
C5orf24
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: C5orf24 (chromosome 5 open reading frame 24)
Type: protein-coding
Summary: chromosome 5 open reading frame 24
Gene Ontology:
Pathways:
UniProt: Q7Z6I8
Entrez ID: 134553
|
Does Activation of POLR3GL in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
POLR3GL
|
response to virus
|
Hepatoma Cell Line
|
Gene: POLR3GL (RNA polymerase III subunit GL)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity. Involved in transcription by RNA polymerase III. Located in nucleus. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: transcription by RNA polymerase III; CC: RNA polymerase III complex, cytosol, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , Gene expression (Transcription), Immune System, Innate Immune System, Pyrimidine metabolism, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human)
UniProt: Q9BT43
Entrez ID: 84265
|
Does Knockout of MPPE1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
MPPE1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MPPE1 (metallophosphoesterase 1)
Type: protein-coding
Summary: Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Involved in GPI anchor biosynthetic process. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: GPI anchor biosynthetic process, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle-mediated transport; MF: GPI-mannose ethanolamine phosphate phosphodiesterase activity, hydrolase activity, manganese ion binding, metal ion binding, phosphoric diester hydrolase activity, protein binding; CC: Golgi apparatus, endoplasmic reticulum exit site, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, nucleoplasm
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Homo sapiens (human)
UniProt: Q53F39
Entrez ID: 65258
|
Does Knockout of GATA3 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
GATA3
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: GATA3 (GATA binding protein 3)
Type: protein-coding
Summary: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009].
Gene Ontology: BP: T cell differentiation, T cell differentiation in thymus, T cell receptor signaling pathway, T-helper 2 cell differentiation, TOR signaling, anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, aortic valve morphogenesis, axon guidance, canonical Wnt signaling pathway, cardiac right ventricle morphogenesis, cartilage development, cell activation, cell differentiation, cell fate commitment, cell fate determination, cell maturation, cell morphogenesis, cell population proliferation, cellular response to BMP stimulus, cellular response to cytokine stimulus, cellular response to interferon-alpha, cellular response to interleukin-4, cellular response to tumor necrosis factor, chromatin remodeling, cochlea development, defense response, developmental growth, ear development, embryonic hemopoiesis, embryonic organ development, erythrocyte differentiation, gene expression, homeostasis of number of cells, humoral immune response, immune system development, immune system process, in utero embryonic development, inflammatory response, innate immune response, inner ear morphogenesis, kidney development, lens development in camera-type eye, lymphocyte migration, macrophage differentiation, male gonad development, mast cell differentiation, mesenchymal to epithelial transition, mesonephros development, negative regulation of DNA-templated transcription, negative regulation of cell cycle, negative regulation of cell motility, negative regulation of cell population proliferation, negative regulation of cell proliferation involved in mesonephros development, negative regulation of endothelial cell apoptotic process, negative regulation of epithelial to mesenchymal transition, negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation, negative regulation of gene expression, negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation, negative regulation of inflammatory response, negative regulation of interleukin-2 production, negative regulation of mammary gland epithelial cell proliferation, negative regulation of transcription by RNA polymerase II, negative regulation of type II interferon production, nephric duct formation, nephric duct morphogenesis, nervous system development, neuron differentiation, neuron migration, norepinephrine biosynthetic process, otic vesicle development, parathyroid gland development, parathyroid hormone secretion, pharyngeal system development, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of T-helper 2 cell cytokine production, positive regulation of cell differentiation, positive regulation of cytokine production, positive regulation of endothelial cell migration, positive regulation of gene expression, positive regulation of interleukin-13 production, positive regulation of interleukin-4 production, positive regulation of interleukin-5 production, positive regulation of miRNA transcription, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of signal transduction, positive regulation of thyroid hormone generation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription regulatory region DNA binding, positive regulation of ureteric bud formation, post-embryonic development, pro-T cell differentiation, regulation of DNA-templated transcription, regulation of T-helper cell differentiation, regulation of cellular response to X-ray, regulation of cytokine production, regulation of developmental process, regulation of epithelial cell differentiation, regulation of establishment of cell polarity, regulation of nephron tubule epithelial cell differentiation, regulation of neuron apoptotic process, regulation of neuron projection development, regulation of transcription by RNA polymerase II, response to estrogen, response to ethanol, response to gamma radiation, response to virus, response to xenobiotic stimulus, signal transduction, sympathetic nervous system development, system development, thymic T cell selection, thymus development, transcription by RNA polymerase II, type IV hypersensitivity, ureter maturation, ureter morphogenesis, ureteric bud formation, uterus development, ventricular septum development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, HMG box domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cis-regulatory region sequence-specific DNA binding, histone methyltransferase binding, identical protein binding, interleukin-2 receptor binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coactivator binding, zinc ion binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Adipogenesis, C-MYB transcription factor network, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Cytokine Signaling in Immune system, Deubiquitination, Development and heterogeneity of the ILC family, Development of ureteric collection system, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Developmental Lineage of Mammary Stem Cells, Developmental Lineages of the Mammary Gland, ESR-mediated signaling, Estrogen-dependent gene expression, Factors involved in megakaryocyte development and platelet production, Formation of the nephric duct, GDNF-RET signaling axis, Gene expression (Transcription), Generic Transcription Pathway, Glucocorticoid receptor regulatory network, Hemostasis, IL-4 signaling pathway, IL27-mediated signaling events, Immune System, Inflammatory bowel disease - Homo sapiens (human), Interleukin-4 and Interleukin-13 signaling, Kidney development, Mesodermal commitment pathway, Metabolism of proteins, Notch Signaling Pathway Netpath, Notch signaling pathway, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Post-translational protein modification, Pre-implantation embryo, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of nuclear SMAD2/3 signaling, Signal Transduction, Signaling by Interleukins, Signaling by Nuclear Receptors, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, T-cell receptor (TCR) signaling pathway, Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Transcriptional cascade regulating adipogenesis, Transcriptional regulation by RUNX1, Ub-specific processing proteases, White fat cell differentiation, gata3 participate in activating the th2 cytokine genes expression
UniProt: P23771
Entrez ID: 2625
|
Does Knockout of ANAPC13 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
ANAPC13
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: ANAPC13 (anaphase promoting complex subunit 13)
Type: protein-coding
Summary: This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; CC: anaphase-promoting complex, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cell cycle, Cell cycle - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, Immune System, Oocyte meiosis - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9BS18
Entrez ID: 25847
|
Does Knockout of CIC in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
CIC
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: CIC (capicua transcriptional repressor)
Type: protein-coding
Summary: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: brain development, learning, lung alveolus development, memory, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, social behavior, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, protein binding; CC: chromatin, nucleoplasm, nucleus, protein-containing complex
Pathways: Spinocerebellar ataxia - Homo sapiens (human)
UniProt: Q96RK0
Entrez ID: 23152
|
Does Knockout of LAMTOR4 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
LAMTOR4
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: LAMTOR4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4)
Type: protein-coding
Summary: Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cellular response to amino acid stimulus; positive regulation of TOR signaling; and protein localization to lysosome. Located in lysosome. Part of Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: TORC1 signaling, cellular response to amino acid stimulus, positive regulation of TOR signaling, positive regulation of TORC1 signaling, protein localization to lysosome, regulation of cell size; MF: guanyl-nucleotide exchange factor activity, molecular adaptor activity, protein binding; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, late endosome membrane, lysosomal membrane, lysosome
Pathways: Amino acids regulate mTORC1, Autophagy, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Homo sapiens (human), mTORC1-mediated signalling
UniProt: Q0VGL1
Entrez ID: 389541
|
Does Knockout of CYP2C19 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
CYP2C19
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CYP2C19 (cytochrome P450 family 2 subfamily C member 19)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: epoxygenase P450 pathway, fatty acid metabolic process, lipid metabolic process, long-chain fatty acid metabolic process, monocarboxylic acid metabolic process, monoterpenoid metabolic process, omega-hydroxylase P450 pathway, steroid metabolic process, terpenoid metabolic process, xenobiotic catabolic process, xenobiotic metabolic process; MF: (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity, enzyme binding, heme binding, iron ion binding, long-chain fatty acid omega-1 hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, oxygen binding, steroid hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, plasma membrane
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Homo sapiens (human), Aspirin ADME, Biological oxidations, CYP2E1 reactions, Cannabinoid receptor signaling, Carbamazepine Metabolism Pathway, Chemical carcinogenesis - Homo sapiens (human), Citalopram Action Pathway, Citalopram Metabolism Pathway, Clomipramine Metabolism Pathway, Clopidogrel Action Pathway, Clopidogrel Metabolism Pathway, Constitutive Androstane Receptor Pathway, Cyclophosphamide Action Pathway, Cyclophosphamide Metabolism Pathway, Cytochrome P450 - arranged by substrate type, Doxepin Metabolism Pathway, Drug ADME, Drug metabolism - cytochrome P450 - Homo sapiens (human), Fatty acid metabolism, Fluoxetine Action Pathway, Fluoxetine Metabolism Pathway, Ibuprofen Action Pathway, Ibuprofen Metabolism Pathway, Imipramine Action Pathway, Imipramine Metabolism Pathway, Linoleic acid metabolism - Homo sapiens (human), Melatonin metabolism and effects, Metabolism, Metabolism of lipids, Metapathway biotransformation Phase I and II, Methadone Action Pathway, Methadone Metabolism Pathway, Nuclear Receptors Meta-Pathway, Oxidation by Cytochrome P450, Phase I - Functionalization of compounds, Phenytoin (Antiarrhythmic) Action Pathway, Pregnane X receptor pathway, Serotonergic synapse - Homo sapiens (human), Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE), Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET), Tamoxifen metabolism, Venlafaxine Metabolism Pathway, Xenobiotics, melatonin degradation I, superpathway of melatonin degradation, superpathway of tryptophan utilization
UniProt: P33261
Entrez ID: 1557
|
Does Knockout of TAF7 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
TAF7
|
cell proliferation
|
Cancer Cell Line
|
Gene: TAF7 (TATA-box binding protein associated factor 7)
Type: protein-coding
Summary: The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase II preinitiation complex assembly, chromatin organization, estrogen receptor signaling pathway, mRNA transcription by RNA polymerase II, negative regulation of DNA-templated transcription, negative regulation of MHC class I biosynthetic process, negative regulation of MHC class II biosynthetic process, negative regulation of protein kinase activity, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of DNA repair, regulation of transcription by RNA polymerase II, spermine transport, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA-binding transcription factor binding, P-TEFb complex binding, RNA polymerase II general transcription initiation factor activity, TFIIH-class transcription factor complex binding, histone H3K27me3 reader activity, histone acetyltransferase binding, nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, protein binding, protein heterodimerization activity, transcription cis-regulatory region binding; CC: MLL1 complex, cytoplasm, male germ cell nucleus, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFTC complex, transcription regulator complex
Pathways: Basal transcription factors - Homo sapiens (human), Disease, Eukaryotic Transcription Initiation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcription of the HIV genome, Transcriptional Regulation by TP53, Viral Infection Pathways
UniProt: Q15545
Entrez ID: 6879
|
Does Knockout of GID8 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
GID8
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: GID8 (GID complex subunit 8 homolog)
Type: protein-coding
Summary: Predicted to enable protein homodimerization activity. Involved in positive regulation of canonical Wnt signaling pathway and positive regulation of cell population proliferation. Located in cell junction; cytosol; and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: protein binding, protein homodimerization activity; CC: cell junction, cytoplasm, cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Ciliary landscape, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: Q9NWU2
Entrez ID: 54994
|
Does Knockout of NAT2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
NAT2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: NAT2 (N-acetyltransferase 2)
Type: protein-coding
Summary: This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2). [provided by RefSeq, Sep 2019].
Gene Ontology: MF: N-hydroxyarylamine O-acetyltransferase activity, acetyltransferase activity, acyltransferase activity, arylamine N-acetyltransferase activity, protein binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Acetylation, Arylamine metabolism, Biological oxidations, Caffeine and Theobromine metabolism, Caffeine metabolism - Homo sapiens (human), Chemical carcinogenesis - Homo sapiens (human), Drug ADME, Drug metabolism - other enzymes - Homo sapiens (human), Metabolism, Metapathway biotransformation Phase I and II, Paracetamol ADME, Phase II - Conjugation of compounds
UniProt: P11245
Entrez ID: 10
|
Does Knockout of MIR149 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
MIR149
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: MIR149 (microRNA 149)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cellular response to fibroblast growth factor stimulus, cellular response to interleukin-6, miRNA-mediated gene silencing by mRNA destabilization, miRNA-mediated post-transcriptional gene silencing, negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, negative regulation of cell migration, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of cell population proliferation, negative regulation of endothelial cell chemotaxis to fibroblast growth factor, negative regulation of epithelial to mesenchymal transition, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of inflammatory response, negative regulation of interleukin-6 production, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of receptor signaling pathway via STAT, negative regulation of stress fiber assembly, negative regulation of toll-like receptor 4 signaling pathway, negative regulation of tumor necrosis factor production, positive regulation of collagen biosynthetic process, positive regulation of transforming growth factor beta3 production; MF: mRNA base-pairing post-transcriptional repressor activity
Pathways: miRNAs involvement in the immune response in sepsis
UniProt:
Entrez ID: 406941
|
Does Knockout of NSF in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
NSF
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase)
Type: protein-coding
Summary: Enables PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in intracellular protein transport; positive regulation of protein catabolic process; and positive regulation of receptor recycling. Located in Golgi apparatus; cytosol; and plasma membrane. Implicated in developmental and epileptic encephalopathy. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Golgi to plasma membrane protein transport, SNARE complex disassembly, exocytosis, intra-Golgi vesicle-mediated transport, intracellular protein transport, plasma membrane fusion, positive regulation of protein catabolic process, positive regulation of receptor recycling, potassium ion transport, protein transport, regulation of exocytosis, vesicle-mediated transport; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein disaggregase activity, PDZ domain binding, SNARE binding, hydrolase activity, ionotropic glutamate receptor binding, metal ion binding, nucleotide binding, protein binding, protein kinase binding, protein-containing complex binding, syntaxin binding, syntaxin-1 binding; CC: GABA-ergic synapse, Golgi apparatus, Golgi stack, cytoplasm, cytosol, dendritic shaft, lysosomal membrane, plasma membrane, postsynaptic specialization, intracellular component
Pathways: Asparagine N-linked glycosylation, BDNF, Brain-derived neurotrophic factor (BDNF) signaling pathway, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, GABAergic synapse - Homo sapiens (human), Glutamate binding, activation of AMPA receptors and synaptic plasticity, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Synaptic Vesicle Pathway, Synaptic vesicle cycle - Homo sapiens (human), Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transmission across Chemical Synapses, Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, gamma-aminobutyric acid receptor life cycle pathway
UniProt: P46459
Entrez ID: 4905
|
Does Knockout of SFRP2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
SFRP2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: SFRP2 (secreted frizzled related protein 2)
Type: protein-coding
Summary: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: BMP signaling pathway, Wnt signaling pathway, Wnt signaling pathway involved in somitogenesis, anterior/posterior pattern specification, apoptotic process, branching involved in blood vessel morphogenesis, canonical Wnt signaling pathway, cardiac left ventricle morphogenesis, cardiac muscle cell apoptotic process, cartilage development, cell differentiation, cell-cell signaling, cellular response to X-ray, chondrocyte development, collagen fibril organization, convergent extension involved in axis elongation, development of primary male sexual characteristics, digestive tract morphogenesis, embryonic digit morphogenesis, hematopoietic stem cell proliferation, male gonad development, mesodermal cell fate specification, negative regulation of BMP signaling pathway, negative regulation of DNA-templated transcription, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell growth, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of dermatome development, negative regulation of epithelial cell proliferation, negative regulation of epithelial to mesenchymal transition, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of gene expression, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of mesodermal cell fate specification, negative regulation of peptidyl-tyrosine phosphorylation, neural tube closure, neural tube development, non-canonical Wnt signaling pathway, outflow tract morphogenesis, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of canonical Wnt signaling pathway, positive regulation of cell adhesion mediated by integrin, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of fat cell differentiation, positive regulation of osteoblast differentiation, positive regulation of transcription by RNA polymerase II, post-anal tail morphogenesis, regulation of Wnt signaling pathway, regulation of apoptotic process, regulation of cell growth, regulation of cell population proliferation, regulation of establishment of planar polarity, regulation of midbrain dopaminergic neuron differentiation, regulation of neuron projection development, regulation of stem cell division, response to nutrient, response to xenobiotic stimulus, sclerotome development, somitogenesis, stem cell fate specification; MF: Wnt-protein binding, endopeptidase activator activity, enzyme activator activity, fibronectin binding, integrin binding, receptor ligand activity; CC: extracellular matrix, extracellular region, extracellular space
Pathways: LncRNA involvement in canonical Wnt signaling and colorectal cancer, Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), ncRNAs involved in Wnt signaling in hepatocellular carcinoma
UniProt: Q96HF1
Entrez ID: 6423
|
Does Knockout of RPF1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
RPF1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: RPF1 (ribosome production factor 1 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing, ribosome biogenesis; MF: RNA binding, protein binding, rRNA binding, rRNA primary transcript binding; CC: nucleolus, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q9H9Y2
Entrez ID: 80135
|
Does Knockout of TNFAIP8L2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
TNFAIP8L2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: TNFAIP8L2 (TNF alpha induced protein 8 like 2)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of T cell activation and negative regulation of inflammatory response. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: T cell activation, immune system process, innate immune response, negative regulation of T cell activation, negative regulation of inflammatory response, regulation of apoptotic process; CC: cytoplasm, lysosome, nucleus
Pathways: Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism
UniProt: Q6P589
Entrez ID: 79626
|
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