prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of TADA2B in Melanoma Cell Line causally result in response to chemicals? | 1 | 95 | Knockout | TADA2B | response to chemicals | Melanoma Cell Line | Gene: TADA2B (transcriptional adaptor 2B)
Type: protein-coding
Summary: TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al... |
Does Knockout of PF4V1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | PF4V1 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: PF4V1 (platelet factor 4 variant 1)
Type: protein-coding
Summary: The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also imp... |
Does Knockout of RABGGTA in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | RABGGTA | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: RABGGTA (Rab geranylgeranyltransferase subunit alpha)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Predicted to be involved in protein geranylgeranylation. Located in nucleoplasm. [provided by Al... |
Does Activation of C3 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | C3 | response to virus | Hepatoma Cell Line | Gene: C3 (complement C3)
Type: protein-coding
Summary: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alp... |
Does Knockout of THSD1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | THSD1 | cell proliferation | Endometrial Cancer Cell Line | Gene: THSD1 (thrombospondin type 1 domain containing 1)
Type: protein-coding
Summary: The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced tr... |
Does Knockout of TICRR in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | TICRR | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: TICRR (TOPBP1 interacting checkpoint and replication regulator)
Type: protein-coding
Summary: Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication,... |
Does Knockout of UBE2D3 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | UBE2D3 | cell proliferation | Colonic Cancer Cell Line | Gene: UBE2D3 (ubiquitin conjugating enzyme E2 D3)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating e... |
Does Knockout of OR5B3 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | OR5B3 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: OR5B3 (olfactory receptor family 5 subfamily B member 3)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of DAW1 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | DAW1 | cell proliferation | Astrocytoma Cell Line | Gene: DAW1 (dynein assembly factor with WD repeats 1)
Type: protein-coding
Summary: Predicted to act upstream of or within several processes, including cerebrospinal fluid circulation; determination of left/right symmetry; and outer dynein arm assembly. Predicted to be located in cilium and extracellula... |
Does Knockout of LIAS in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | LIAS | cell proliferation | Colonic Cancer Cell Line | Gene: LIAS (lipoic acid synthetase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a pote... |
Does Knockout of ARHGAP40 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | ARHGAP40 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ARHGAP40 (Rho GTPase activating protein 40)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of actin filament polymerization and regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. Predicte... |
Does Knockout of POLR1A in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | POLR1A | cell proliferation | acute lymphoblastic leukemia cell line | Gene: POLR1A (RNA polymerase I subunit A)
Type: protein-coding
Summary: The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene ... |
Does Inhibition of ZNF691 in Gastric tumor organoid model causally result in response to chemicals? | 1 | 2,482 | Inhibition | ZNF691 | response to chemicals | Gastric tumor organoid model | Gene: ZNF691 (zinc finger protein 691)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted t... |
Does Knockout of FAM149B1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | FAM149B1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: FAM149B1 (family with sequence similarity 149 member B1)
Type: protein-coding
Summary: Involved in cilium assembly and protein localization to cilium. Predicted to be located in cilium. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP:... |
Does Knockout of MSX2 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | MSX2 | cell proliferation | Multiple Myeloma Cell Line | Gene: MSX2 (msh homeobox 2)
Type: protein-coding
Summary: This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for prop... |
Does Knockout of KCNH7 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | KCNH7 | cell proliferation | Medulloblastoma Cell Line | Gene: KCNH7 (potassium voltage-gated channel subfamily H member 7)
Type: protein-coding
Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitt... |
Does Knockout of DDX52 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | DDX52 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: DDX52 (DExD-box helicase 52)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of SSU-rRNA; MF: ATP binding, ATP hydrolysis... |
Does Knockout of JAZF1 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | JAZF1 | cell proliferation | Melanoma Cell Line | Gene: JAZF1 (JAZF zinc finger 1)
Type: protein-coding
Summary: This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants w... |
Does Knockout of ANKRD13A in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | ANKRD13A | cell proliferation | Glioblastoma Cell Line | Gene: ANKRD13A (ankyrin repeat domain 13A)
Type: protein-coding
Summary: Enables ubiquitin-dependent protein binding activity. Involved in negative regulation of protein localization to endosome and negative regulation of receptor internalization. Located in late endosome; perinuclear region of cytoplas... |
Does Knockout of MIR4668 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | MIR4668 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: MIR4668 (microRNA 4668)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of TRIP12 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | TRIP12 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: TRIP12 (thyroid hormone receptor interactor 12)
Type: protein-coding
Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by ... |
Does Knockout of TRIP11 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | TRIP11 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: TRIP11 (thyroid hormone receptor interactor 11)
Type: protein-coding
Summary: This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes... |
Does Activation of CHM in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | CHM | protein/peptide accumulation | T cell | Gene: CHM (CHM Rab escort protein)
Type: protein-coding
Summary: This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transf... |
Does Knockout of ST6GALNAC4 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | ST6GALNAC4 | cell proliferation | Cancer Cell Line | Gene: ST6GALNAC4 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4)
Type: protein-coding
Summary: The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycop... |
Does Knockout of BRK1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | BRK1 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)
Type: protein-coding
Summary: Enables identical protein binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction and positive regulation of cellular component organization. Located in ext... |
Does Knockout of CCM2L in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 1 | 1,480 | Knockout | CCM2L | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: CCM2L (CCM2 like scaffold protein)
Type: protein-coding
Summary: Predicted to act upstream of or within several processes, including heart development; negative regulation of homotypic cell-cell adhesion; and positive regulation of fibroblast growth factor production. [provided by Alliance of Geno... |
Does Knockout of EP400 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | EP400 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: EP400 (E1A binding protein p400)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP binding activity; ATP-dependent chromatin remodeler activity; and protein antigen binding activity. Involved in histone H2A acetylation and histone H4 acetylation. Part of NuA4 histo... |
Does Knockout of FAM200A in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | FAM200A | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: FAM200A (family with sequence similarity 200 member A)
Type: protein-coding
Summary: This gene encodes a protein of unknown function. The protein is weakly similar to transposase-like proteins in human and mouse. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways:
... |
Does Knockout of GNG4 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | GNG4 | cell proliferation | Astrocytoma Cell Line | Gene: GNG4 (G protein subunit gamma 4)
Type: protein-coding
Summary: Predicted to enable G-protein beta-subunit binding activity. Involved in negative regulation of cell growth. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-c... |
Does Knockout of IMPDH2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | IMPDH2 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: IMPDH2 (inosine monophosphate dehydrogenase 2)
Type: protein-coding
Summary: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded ... |
Does Knockout of YAP1 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | YAP1 | cell proliferation | Cancer Cell Line | Gene: YAP1 (Yes1 associated transcriptional regulator)
Type: protein-coding
Summary: This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of m... |
Does Knockout of UROS in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | UROS | RNA accumulation | Monocytic Leukemia Cell Line | Gene: UROS (uroporphyrinogen III synthase)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 200... |
Does Knockout of TRAPPC1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | TRAPPC1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: TRAPPC1 (trafficking protein particle complex subunit 1)
Type: protein-coding
Summary: This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) ... |
Does Knockout of THEM4 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | THEM4 | cell proliferation | Monocytic Leukemia Cell Line | Gene: THEM4 (thioesterase superfamily member 4)
Type: protein-coding
Summary: Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in t... |
Does Knockout of RAB10 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | RAB10 | cell proliferation | Prostate Cancer Cell Line | Gene: RAB10 (RAB10, member RAS oncogene family)
Type: protein-coding
Summary: RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[sup... |
Does Knockout of CELF6 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | CELF6 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: CELF6 (CUGBP Elav-like family member 6)
Type: protein-coding
Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this pro... |
Does Knockout of VPS16 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | VPS16 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: VPS16 (VPS16 core subunit of CORVET and HOPS complexes)
Type: protein-coding
Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) ge... |
Does Knockout of APOC4 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | APOC4 | cell proliferation | Monocytic Leukemia Cell Line | Gene: APOC4 (apolipoprotein C4)
Type: protein-coding
Summary: This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with cor... |
Does Knockout of ADCY1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | ADCY1 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: ADCY1 (adenylate cyclase 1)
Type: protein-coding
Summary: This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results ... |
Does Knockout of POLD2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | POLD2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: POLD2 (DNA polymerase delta 2, accessory subunit)
Type: protein-coding
Summary: This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The enco... |
Does Knockout of ZPR1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | ZPR1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ZPR1 (ZPR1 zinc finger)
Type: protein-coding
Summary: The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to ... |
Does Knockout of RANBP17 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | RANBP17 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: RANBP17 (RAN binding protein 17)
Type: protein-coding
Summary: The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or mor... |
Does Knockout of IGHV3-7 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | IGHV3-7 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: IGHV3-7 (immunoglobulin heavy variable 3-7)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of BRCA1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | BRCA1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: BRCA1 (BRCA1 DNA repair associated)
Type: protein-coding
Summary: This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combine... |
Does Knockout of CAST in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | CAST | cell proliferation | Colonic Cancer Cell Line | Gene: CAST (calpastatin)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of ZNF208 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | ZNF208 | cell proliferation | Colonic Cancer Cell Line | Gene: ZNF208 (zinc finger protein 208)
Type: protein-coding
Summary: Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed th... |
Does Knockout of TCERG1 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | TCERG1 | cell proliferation | Colorectal Cancer Cell Line | Gene: TCERG1 (transcription elongation regulator 1)
Type: protein-coding
Summary: This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains... |
Does Knockout of NECTIN1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | NECTIN1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: NECTIN1 (nectin cell adhesion molecule 1)
Type: protein-coding
Summary: This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule th... |
Does Knockout of PIP4K2C in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | PIP4K2C | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma)
Type: protein-coding
Summary: Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and identical protein binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic ... |
Does Knockout of DCLRE1A in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | DCLRE1A | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: DCLRE1A (DNA cross-link repair 1A)
Type: protein-coding
Summary: This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cyc... |
Does Knockout of SAMD7 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | SAMD7 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: SAMD7 (sterile alpha motif domain containing 7)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be located in cytoplasm. Predicted to be active i... |
Does Knockout of CELA2B in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | CELA2B | cell proliferation | Neuroblastoma Cell Line | Gene: CELA2B (chymotrypsin like elastase 2B)
Type: protein-coding
Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the... |
Does Knockout of CTR9 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | CTR9 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: CTR9 (CTR9 component of Paf1/RNA polymerase II complex)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the PAF1 complex, which associates with RNA polymerase II and functions in transcriptional regulation and elongation. This complex also plays a role in the modif... |
Does Knockout of RUVBL1 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | RUVBL1 | cell proliferation | Renal Cancer Cell Line | Gene: RUVBL1 (RuvB like AAA ATPase 1)
Type: protein-coding
Summary: This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisu... |
Does Knockout of MUC19 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | MUC19 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: MUC19 (mucin 19, oligomeric (gene/pseudogene))
Type: protein-coding
Summary: This gene encodes a member of the gel-forming mucin protein family. Mucin family members are glycoproteins that have tandem repeats which are extensively O-glycosylated. The structural features of mucin proteins are respo... |
Does Knockout of HADH in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | HADH | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: HADH (hydroxyacyl-CoA dehydrogenase)
Type: protein-coding
Summary: This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathwa... |
Does Knockout of ORAI3 in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | ORAI3 | cell proliferation | Prostate Cancer Cell Line | Gene: ORAI3 (ORAI calcium release-activated calcium modulator 3)
Type: protein-coding
Summary: Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be located in plasma membrane. Predicted to be integral component of membrane... |
Does Knockout of S100A12 in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | S100A12 | RNA accumulation | Monocytic Leukemia Cell Line | Gene: S100A12 (S100 calcium binding protein A12)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in th... |
Does Knockout of ZNF76 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | ZNF76 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: ZNF76 (zinc finger protein 76)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located i... |
Does Knockout of HPR in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | HPR | response to virus | Cervical Adenocarcinoma Cell Line | Gene: HPR (haptoglobin-related protein)
Type: protein-coding
Summary: This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascula... |
Does Knockout of VEGFC in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | VEGFC | cell proliferation | Monocytic Leukemia Cell Line | Gene: VEGFC (vascular endothelial growth factor C)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also a... |
Does Knockout of MAMDC4 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | MAMDC4 | response to virus | Hepatoma Cell Line | Gene: MAMDC4 (MAM domain containing 4)
Type: protein-coding
Summary: Predicted to be involved in protein transport. Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: nervous system develop... |
Does Knockout of RCC1L in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | RCC1L | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: RCC1L (RCC1 like)
Type: protein-coding
Summary: This gene encodes a protein containing regulator of chromosome condensation 1-like repeats. The encoded protein may function as a guanine nucleotide exchange factor. This gene is located in a region of chromosome 7 that is deleted in Williams-Beuren ... |
Does Knockout of UFD1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | UFD1 | cell proliferation | Endometrial Cancer Cell Line | Gene: UFD1 (ubiquitin recognition factor in ER associated degradation 1)
Type: protein-coding
Summary: The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinat... |
Does Knockout of SUPT6H in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | SUPT6H | cell proliferation | Bladder Carcinoma | Gene: SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor)
Type: protein-coding
Summary: Enables histone binding activity. Involved in negative regulation of histone H3-K27 methylation and positive regulation of transcription elongation from RNA polymerase II promoter. Predicted ... |
Does Knockout of ADIPOR1 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | ADIPOR1 | response to chemicals | Glioblastoma Cell Line | Gene: ADIPOR1 (adiponectin receptor 1)
Type: protein-coding
Summary: This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an ... |
Does Knockout of SEZ6L2 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | SEZ6L2 | cell proliferation | Colorectal Cancer Cell Line | Gene: SEZ6L2 (seizure related 6 homolog like 2)
Type: protein-coding
Summary: This gene encodes a seizure-related protein that is localized on the cell surface. The gene is located in a region of chromosome 16p11.2 that is thought to contain candidate genes for autism spectrum disorders (ASD), though th... |
Does Knockout of PTPRCAP in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | PTPRCAP | response to chemicals | Melanoma Cell Line | Gene: PTPRCAP (protein tyrosine phosphatase receptor type C associated protein)
Type: protein-coding
Summary: The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation.... |
Does Knockout of TTR in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | TTR | response to virus | Huh-7 Cell | Gene: TTR (transthyretin)
Type: protein-coding
Summary: This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebros... |
Does Knockout of YAF2 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | YAF2 | cell proliferation | Gastric Cancer Cell Line | Gene: YAF2 (YY1 associated factor 2)
Type: protein-coding
Summary: This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcrip... |
Does Knockout of LUC7L3 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | LUC7L3 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: LUC7L3 (LUC7 like 3 pre-mRNA splicing factor)
Type: protein-coding
Summary: This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and s... |
Does Knockout of FUT2 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | FUT2 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: FUT2 (fucosyltransferase 2 (H blood group))
Type: protein-coding
Summary: This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. The encoded protein is important for the final step in the soluble ABO blood group antigen synthesis pathway. It is also involved in cell-cell i... |
Does Knockout of SLC5A4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | SLC5A4 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: SLC5A4 (solute carrier family 5 member 4)
Type: protein-coding
Summary: Predicted to enable glucose:sodium symporter activity and proton transmembrane transporter activity. Predicted to be involved in sodium ion transport. Predicted to act upstream of or within proton transmembrane transport. Pred... |
Does Knockout of SASS6 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | SASS6 | cell proliferation | Colonic Cancer Cell Line | Gene: SASS6 (SAS-6 centriolar assembly protein)
Type: protein-coding
Summary: The protein encoded by this gene is a central component of centrioles and is necessary for their duplication and function. Centrioles adopt a cartwheel-shaped structure, with the encoded protein forming the hub and spokes insi... |
Does Knockout of KAT14 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | KAT14 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: KAT14 (lysine acetyltransferase 14)
Type: protein-coding
Summary: CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form ... |
Does Knockout of DLG3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | DLG3 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: DLG3 (discs large MAGUK scaffold protein 3)
Type: protein-coding
Summary: This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell prolifer... |
Does Knockout of UQCRC2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | UQCRC2 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: UQCRC2 (ubiquinol-cytochrome c reductase core protein 2)
Type: protein-coding
Summary: The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondria... |
Does Knockout of RUVBL2 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | RUVBL2 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: RUVBL2 (RuvB like AAA ATPase 2)
Type: protein-coding
Summary: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene produ... |
Does Knockout of SNRPF in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | SNRPF | cell proliferation | Monocytic Leukemia Cell Line | Gene: SNRPF (small nuclear ribonucleoprotein polypeptide F)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in spliceosomal snRNP assembly. Located in cytosol and nucleus. Part of several cellular components, including methylosome; nucleus; and pICln-Sm protein complex. Biomarker of... |
Does Knockout of KLRF2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | KLRF2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: KLRF2 (killer cell lectin like receptor F2)
Type: protein-coding
Summary: Enables protein homodimerization activity. Predicted to be involved in natural killer cell degranulation and positive regulation of cytokine production. Predicted to act upstream of or within natural killer cell activation a... |
Does Knockout of ZNF230 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | ZNF230 | response to virus | Hepatoma Cell Line | Gene: ZNF230 (zinc finger protein 230)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of FHL1 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | FHL1 | cell proliferation | Multiple Myeloma Cell Line | Gene: FHL1 (four and a half LIM domains 1)
Type: protein-coding
Summary: This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc fi... |
Does Knockout of P2RX2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | P2RX2 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: P2RX2 (purinergic receptor P2X 2)
Type: protein-coding
Summary: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple ... |
Does Knockout of WDR18 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | WDR18 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: WDR18 (WD repeat domain 18)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or m... |
Does Knockout of RHOU in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | RHOU | cell proliferation | Cancer Cell Line | Gene: RHOU (ras homolog family member U)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation o... |
Does Knockout of RPL35 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | RPL35 | cell proliferation | Monocytic Leukemia Cell Line | Gene: RPL35 (ribosomal protein L35)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of IFT22 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | IFT22 | cell proliferation | Glioblastoma Cell Line | Gene: IFT22 (intraflagellar transport 22)
Type: protein-coding
Summary: Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to be located in ciliary tip. Predicted to be part of intraciliary transport particle B. Predicted to be active in endomembr... |
Does Knockout of MCM7 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | MCM7 | cell proliferation | Cancer Cell Line | Gene: MCM7 (minichromosome maintenance complex component 7)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex forme... |
Does Knockout of INHA in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | INHA | cell proliferation | Colonic Cancer Cell Line | Gene: INHA (inhibin subunit alpha)
Type: protein-coding
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin ... |
Does Knockout of DGCR8 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | DGCR8 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: DGCR8 (DGCR8 microprocessor complex subunit)
Type: protein-coding
Summary: This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the n... |
Does Knockout of NUDT21 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | NUDT21 | cell proliferation | Gastric Cancer Cell Line | Gene: NUDT21 (nudix hydrolase 21)
Type: protein-coding
Summary: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end process... |
Does Knockout of ZMYND8 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | ZMYND8 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: ZMYND8 (zinc finger MYND-type containing 8)
Type: protein-coding
Summary: The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell ... |
Does Knockout of BAP1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | BAP1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: BAP1 (BRCA1 associated deubiquitinase 1)
Type: protein-coding
Summary: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility prot... |
Does Knockout of PSMC5 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | PSMC5 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: PSMC5 (proteasome 26S subunit, ATPase 5)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are co... |
Does Knockout of KCNIP2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | KCNIP2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: KCNIP2 (potassium voltage-gated channel interacting protein 2)
Type: protein-coding
Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family... |
Does Knockout of SDHD in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | SDHD | cell proliferation | Monocytic Leukemia Cell Line | Gene: SDHD (succinate dehydrogenase complex subunit D)
Type: protein-coding
Summary: This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix si... |
Does Knockout of RACGAP1 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | RACGAP1 | cell proliferation | Astrocytoma Cell Line | Gene: RACGAP1 (Rac GTPase activating protein 1)
Type: protein-coding
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of R... |
Does Knockout of PDZD2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | PDZD2 | cell proliferation | Colonic Cancer Cell Line | Gene: PDZD2 (PDZ domain containing 2)
Type: protein-coding
Summary: The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a c... |
Does Knockout of HAUS1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | HAUS1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: HAUS1 (HAUS augmin like complex subunit 1)
Type: protein-coding
Summary: HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin compl... |
Does Knockout of COPS8 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | COPS8 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: COPS8 (COP9 signalosome subunit 8)
Type: protein-coding
Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalo... |
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