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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of TADA2B in Melanoma Cell Line causally result in response to chemicals?
| 1
| 95
|
Knockout
|
TADA2B
|
response to chemicals
|
Melanoma Cell Line
|
Gene: TADA2B (transcriptional adaptor 2B)
Type: protein-coding
Summary: TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010].
Gene Ontology: BP: chromatin remodeling, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing, regulation of transcription by RNA polymerase II; MF: chromatin binding, metal ion binding, protein binding, transcription coactivator activity, zinc ion binding; CC: SAGA complex, SAGA-type complex, nucleoplasm, nucleus
Pathways: Direct p53 effectors
UniProt: Q86TJ2
Entrez ID: 93624
|
Does Knockout of PF4V1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
PF4V1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: PF4V1 (platelet factor 4 variant 1)
Type: protein-coding
Summary: The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cellular response to lipopolysaccharide, chemotaxis, defense response, immune response, inflammatory response, neutrophil chemotaxis, signal transduction; MF: CXCR chemokine receptor binding, chemokine activity, cytokine activity, heparin binding, protein binding; CC: extracellular region, extracellular space
Pathways: Cell surface interactions at the vascular wall, Chemokine signaling pathway - Homo sapiens (human), Common Pathway of Fibrin Clot Formation, Cytokine-cytokine receptor interaction - Homo sapiens (human), Formation of Fibrin Clot (Clotting Cascade), Hemostasis, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: P10720
Entrez ID: 5197
|
Does Knockout of RABGGTA in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
RABGGTA
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: RABGGTA (Rab geranylgeranyltransferase subunit alpha)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Predicted to be involved in protein geranylgeranylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein geranylgeranylation, protein modification process, visual perception; MF: Rab geranylgeranyltransferase activity, prenyltransferase activity, protein binding, protein geranylgeranyltransferase activity, protein prenyltransferase activity, small GTPase binding, transferase activity, zinc ion binding; CC: Rab-protein geranylgeranyltransferase complex, cytoplasm, cytosol, plasma membrane
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RAB geranylgeranylation, RNA Polymerase II Transcription, Signaling events mediated by PRL, TP53 Regulates Transcription of Cell Death Genes, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, Transcriptional Regulation by TP53
UniProt: Q92696
Entrez ID: 5875
|
Does Activation of C3 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
C3
|
response to virus
|
Hepatoma Cell Line
|
Gene: C3 (complement C3)
Type: protein-coding
Summary: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: B cell activation, G protein-coupled receptor signaling pathway, activation of membrane attack complex, amyloid-beta clearance, complement activation, complement activation, GZMK pathway, complement activation, alternative pathway, complement activation, classical pathway, complement activation, lectin pathway, complement receptor mediated signaling pathway, complement-dependent cytotoxicity, complement-mediated synapse pruning, fatty acid metabolic process, immune response, immune system process, inflammatory response, innate immune response, killing of cells of another organism, leukocyte chemotaxis, lipid metabolic process, neuron remodeling, opsonization, oviduct epithelium development, positive regulation of D-glucose transmembrane transport, positive regulation of G protein-coupled receptor signaling pathway, positive regulation of activation of membrane attack complex, positive regulation of angiogenesis, positive regulation of apoptotic cell clearance, positive regulation of lipid storage, positive regulation of phagocytosis, positive regulation of phagocytosis, engulfment, positive regulation of protein phosphorylation, positive regulation of receptor-mediated endocytosis, positive regulation of type IIa hypersensitivity, positive regulation of vascular endothelial growth factor production, protein maturation, regulation of triglyceride biosynthetic process, response to bacterium, signal transduction, vertebrate eye-specific patterning; MF: C5L2 anaphylatoxin chemotactic receptor binding, antigen binding, chemokine activity, endopeptidase inhibitor activity, protein binding, receptor ligand activity, signaling receptor binding; CC: azurophil granule lumen, blood microparticle, cell surface, classical-complement-pathway C3/C5 convertase complex, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, plasma membrane, protein-containing complex, secretory granule lumen, symbiont cell surface
Pathways: 16p11.2 distal deletion syndrome, Allograft Rejection, Beta2 integrin cell surface interactions, Cells and molecules involved in local acute inflammatory response, Chagas disease - Homo sapiens (human), Complement Activation, Complement and Coagulation Cascades, Complement and coagulation cascades - Homo sapiens (human), Complement system, Coronavirus disease - COVID-19 - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Legionellosis - Homo sapiens (human), Leishmaniasis - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), Pertussis - Homo sapiens (human), Phagosome - Homo sapiens (human), Shigellosis - Homo sapiens (human), Staphylococcus aureus infection - Homo sapiens (human), Systemic lupus erythematosus - Homo sapiens (human), TYROBP causal network in microglia, Tuberculosis - Homo sapiens (human), Validated nuclear estrogen receptor alpha network, Validated nuclear estrogen receptor beta network, Viral carcinogenesis - Homo sapiens (human), alternative complement pathway, classical complement pathway, lectin induced complement pathway
UniProt: P01024
Entrez ID: 718
|
Does Knockout of THSD1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
THSD1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: THSD1 (thrombospondin type 1 domain containing 1)
Type: protein-coding
Summary: The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jan 2009].
Gene Ontology: MF: extracellular matrix binding, protein binding; CC: anchoring junction, cell periphery, cytoplasm, cytosol, endosome, endosome membrane, extracellular region, focal adhesion, membrane
Pathways: Defective B3GALTL causes PpS, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q9NS62
Entrez ID: 55901
|
Does Knockout of TICRR in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
TICRR
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: TICRR (TOPBP1 interacting checkpoint and replication regulator)
Type: protein-coding
Summary: Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, regulation of DNA-templated DNA replication initiation, response to ionizing radiation; MF: chromatin binding, protein binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Transition, Mitotic G2-G2/M phases
UniProt: Q7Z2Z1
Entrez ID: 90381
|
Does Knockout of UBE2D3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
UBE2D3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: UBE2D3 (ubiquitin conjugating enzyme E2 D3)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: DNA damage response, DNA repair, apoptotic process, negative regulation of BMP signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of protein targeting to mitochondrion, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein K6-linked ubiquitination, protein autoubiquitination, protein modification process, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: cytosol, endosome, endosome membrane, extracellular exosome, membrane, nucleoplasm, nucleus, plasma membrane
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Autophagy, BARD1 signaling events, BMP Signalling Pathway, Canonical NF-kappaB pathway, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, DDX58/IFIH1-mediated induction of interferon-alpha/beta, Death Receptor Signaling, Downregulation of SMAD2/3:SMAD4 transcriptional activity, E3 ubiquitin ligases ubiquitinate target proteins, Gene expression (Transcription), Generic Transcription Pathway, IKK complex recruitment mediated by RIP1, Immune System, Inactivation of CSF3 (G-CSF) signaling, Innate Immune System, Internalization of ErbB1, Macroautophagy, Metabolism of proteins, Mitophagy, MyD88-independent TLR4 cascade , Neddylation, Negative regulators of DDX58/IFIH1 signaling, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PINK1-PRKN Mediated Mitophagy, Peroxisomal protein import, Post-translational protein modification, Proteasome Degradation, Protein localization, Protein processing in endoplasmic reticulum - Homo sapiens (human), Protein ubiquitination, RNA Polymerase II Transcription, Regulation of TNFR1 signaling, Ribosome-associated quality control, Selective autophagy, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by BMP, Signaling by CSF3 (G-CSF), Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF_beta_Receptor, TICAM1, RIP1-mediated IKK complex recruitment, TNF signaling, TNFalpha, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Translation, Ubiquitin mediated proteolysis - Homo sapiens (human), ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
UniProt: P61077
Entrez ID: 7323
|
Does Knockout of OR5B3 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
OR5B3
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: OR5B3 (olfactory receptor family 5 subfamily B member 3)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NH48
Entrez ID: 441608
|
Does Knockout of DAW1 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
DAW1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: DAW1 (dynein assembly factor with WD repeats 1)
Type: protein-coding
Summary: Predicted to act upstream of or within several processes, including cerebrospinal fluid circulation; determination of left/right symmetry; and outer dynein arm assembly. Predicted to be located in cilium and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: axonemal dynein complex assembly, cerebrospinal fluid circulation, determination of left/right symmetry, epithelial cilium movement involved in extracellular fluid movement, establishment of localization in cell, heart development, intraciliary transport, outer dynein arm assembly, protein polyubiquitination; MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: SCF ubiquitin ligase complex, cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, extracellular region, motile cilium
Pathways:
UniProt: Q8N136
Entrez ID: 164781
|
Does Knockout of LIAS in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
LIAS
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: LIAS (lipoic acid synthetase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant. The deficient expression of this enzyme has been linked to conditions such as diabetes, atherosclerosis and neonatal-onset epilepsy. Alternative splicing occurs at this locus, and several transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: inflammatory response, lipoate biosynthetic process, neural tube closure, protein lipoylation, response to lipopolysaccharide, response to oxidative stress; MF: 4 iron, 4 sulfur cluster binding, catalytic activity, iron-sulfur cluster binding, lipoate synthase activity, metal ion binding, sulfurtransferase activity, transferase activity; CC: mitochondrial matrix, mitochondrion
Pathways: Lipoic acid metabolism - Homo sapiens (human), Metabolism of proteins, Post-translational protein modification, Protein lipoylation, lipoate biosynthesis and incorporation
UniProt: O43766
Entrez ID: 11019
|
Does Knockout of ARHGAP40 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
ARHGAP40
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ARHGAP40 (Rho GTPase activating protein 40)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of actin filament polymerization and regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of actin filament polymerization, regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity; CC: cytoplasm, cytosol
Pathways: CDC42 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q5TG30
Entrez ID: 343578
|
Does Knockout of POLR1A in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
POLR1A
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: POLR1A (RNA polymerase I subunit A)
Type: protein-coding
Summary: The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016].
Gene Ontology: BP: DNA-templated transcription, negative regulation of protein localization to nucleolus, nucleolar large rRNA transcription by RNA polymerase I, transcription by RNA polymerase I; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, DNA/RNA hybrid binding, chromatin binding, magnesium ion binding, metal ion binding, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, chromatin, chromosome, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair , Positive epigenetic regulation of rRNA expression, Pyrimidine metabolism, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Homo sapiens (human), TNFalpha, tumor suppressor arf inhibits ribosomal biogenesis
UniProt: O95602
Entrez ID: 25885
|
Does Inhibition of ZNF691 in Gastric tumor organoid model causally result in response to chemicals?
| 1
| 2,482
|
Inhibition
|
ZNF691
|
response to chemicals
|
Gastric tumor organoid model
|
Gene: ZNF691 (zinc finger protein 691)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q5VV52
Entrez ID: 51058
|
Does Knockout of FAM149B1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
FAM149B1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: FAM149B1 (family with sequence similarity 149 member B1)
Type: protein-coding
Summary: Involved in cilium assembly and protein localization to cilium. Predicted to be located in cilium. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell projection organization, cilium assembly, protein localization to cilium; CC: cell projection, cilium
Pathways:
UniProt: Q96BN6
Entrez ID: 317662
|
Does Knockout of MSX2 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
MSX2
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: MSX2 (msh homeobox 2)
Type: protein-coding
Summary: This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: BMP signaling pathway, activation of meiosis, animal organ morphogenesis, anterior/posterior pattern specification, bone morphogenesis, bone trabecula formation, branching involved in mammary gland duct morphogenesis, cardiac conduction system development, cartilage development, cell surface receptor signaling pathway involved in heart development, cellular response to estradiol stimulus, cellular response to growth factor stimulus, chondrocyte development, cranial suture morphogenesis, embryonic digit morphogenesis, embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, embryonic morphogenesis, embryonic nail plate morphogenesis, enamel mineralization, endochondral bone growth, epithelial to mesenchymal transition involved in endocardial cushion formation, frontal suture morphogenesis, mammary gland epithelium development, mesenchymal cell apoptotic process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of fat cell differentiation, negative regulation of keratinocyte differentiation, negative regulation of transcription by RNA polymerase II, odontogenesis, ossification, osteoblast development, osteoblast differentiation, outflow tract morphogenesis, outflow tract septum morphogenesis, positive regulation of BMP signaling pathway, positive regulation of mesenchymal cell apoptotic process, positive regulation of osteoblast differentiation, positive regulation of timing of catagen, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of transcription by RNA polymerase II, signal transduction involved in regulation of gene expression, stem cell differentiation, wound healing, wound healing, spreading of epidermal cells; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, cytosol, nuclear speck, nucleus, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Neural Crest Differentiation, RNA Polymerase II Transcription, Regulation of RUNX2 expression and activity, Transcriptional regulation by RUNX2
UniProt: P35548
Entrez ID: 4488
|
Does Knockout of KCNH7 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
KCNH7
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: KCNH7 (potassium voltage-gated channel subfamily H member 7)
Type: protein-coding
Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, regulation of membrane potential, transmembrane transport; MF: heme binding, inward rectifier potassium channel activity, monoatomic ion channel activity, potassium channel activity, voltage-gated potassium channel activity; CC: membrane, monoatomic ion channel complex, plasma membrane
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: Q9NS40
Entrez ID: 90134
|
Does Knockout of DDX52 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
DDX52
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: DDX52 (DExD-box helicase 52)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of SSU-rRNA; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: membrane, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y2R4
Entrez ID: 11056
|
Does Knockout of JAZF1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
JAZF1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: JAZF1 (JAZF zinc finger 1)
Type: protein-coding
Summary: This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008].
Gene Ontology: BP: lipid metabolic process, negative regulation of transcription by RNA polymerase II; MF: metal ion binding, protein binding, transcription corepressor activity, zinc ion binding; CC: cytosol, fibrillar center, nucleoplasm, nucleus, transcription repressor complex
Pathways:
UniProt: Q86VZ6
Entrez ID: 221895
|
Does Knockout of ANKRD13A in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
ANKRD13A
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ANKRD13A (ankyrin repeat domain 13A)
Type: protein-coding
Summary: Enables ubiquitin-dependent protein binding activity. Involved in negative regulation of protein localization to endosome and negative regulation of receptor internalization. Located in late endosome; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of protein localization to endosome, negative regulation of receptor internalization; MF: ubiquitin-modified protein reader activity; CC: cytoplasm, endosome, late endosome, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q8IZ07
Entrez ID: 88455
|
Does Knockout of MIR4668 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
MIR4668
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: MIR4668 (microRNA 4668)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100616114
|
Does Knockout of TRIP12 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
TRIP12
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: TRIP12 (thyroid hormone receptor interactor 12)
Type: protein-coding
Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, heterochromatin boundary formation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of embryonic development, ubiquitin-dependent protein catabolic process; MF: nuclear thyroid hormone receptor binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: cytosol, nuclear speck, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q14669
Entrez ID: 9320
|
Does Knockout of TRIP11 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
TRIP11
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: TRIP11 (thyroid hormone receptor interactor 11)
Type: protein-coding
Summary: This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010].
Gene Ontology: BP: Golgi organization, Golgi ribbon formation, bone development, cartilage development, chondrocyte differentiation involved in endochondral bone morphogenesis, endoplasmic reticulum to Golgi vesicle-mediated transport, inner ear receptor cell stereocilium organization, positive regulation of DNA-templated transcription, protein glycosylation, protein transmembrane transport, transcription by RNA polymerase II, ventricular septum development, vesicle tethering to Golgi; MF: protein binding, small GTPase binding, transcription coactivator activity; CC: Golgi apparatus, Golgi membrane, acrosomal membrane, cilium, cis-Golgi network, cytoplasm, cytoskeleton, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, transport vesicle
Pathways: Cilium Assembly, Disease, Diseases of signal transduction by growth factor receptors and second messengers, FLT3 signaling in disease, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Intraflagellar transport, Membrane Trafficking, Organelle biogenesis and maintenance, Signaling by FLT3 fusion proteins, Vesicle-mediated transport
UniProt: Q15643
Entrez ID: 9321
|
Does Activation of CHM in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
CHM
|
protein/peptide accumulation
|
T cell
|
Gene: CHM (CHM Rab escort protein)
Type: protein-coding
Summary: This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: intracellular protein transport, protein geranylgeranylation, protein targeting to membrane, small GTPase-mediated signal transduction, vesicle-mediated transport, visual perception; MF: GDP-dissociation inhibitor activity, GTPase activator activity, Rab geranylgeranyltransferase activity, protein binding, small GTPase binding; CC: Rab-protein geranylgeranyltransferase complex, cytoplasm, cytosol, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, RNA Polymerase II Transcription, Rab regulation of trafficking, TP53 Regulates Transcription of Cell Death Genes, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, Transcriptional Regulation by TP53, Vesicle-mediated transport
UniProt: P24386
Entrez ID: 1121
|
Does Knockout of ST6GALNAC4 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
ST6GALNAC4
|
cell proliferation
|
Cancer Cell Line
|
Gene: ST6GALNAC4 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4)
Type: protein-coding
Summary: The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. Readthrough transcripts exist for this gene and the downstream ST6GALNAC6 gene. [provided by RefSeq, Jan 2022].
Gene Ontology: BP: ganglioside biosynthetic process, glycolipid metabolic process, lipid metabolic process, oligosaccharide metabolic process, protein O-linked glycosylation via N-acetyl-galactosamine, protein glycosylation, viral protein processing; MF: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity, alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity, glycosyltransferase activity, sialyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Disease, Globo Sphingolipid Metabolism, Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human), Infectious disease, Late SARS-CoV-2 Infection Events, Maturation of protein 3a, Maturation of spike protein, Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis, Termination of O-glycan biosynthesis, Translation of Structural Proteins, Viral Infection Pathways
UniProt: Q9H4F1
Entrez ID: 27090
|
Does Knockout of BRK1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
BRK1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)
Type: protein-coding
Summary: Enables identical protein binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction and positive regulation of cellular component organization. Located in extracellular exosome. Part of SCAR complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Rac protein signal transduction, actin cytoskeleton organization, actin filament organization, cell motility, fibroblast proliferation, in utero embryonic development, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of fibroblast proliferation, positive regulation of lamellipodium assembly, positive regulation of protein-containing complex assembly, regulation of actin polymerization or depolymerization; MF: identical protein binding, protein binding, protein-containing complex binding, small GTPase binding; CC: SCAR complex, cytoplasm, cytoskeleton, cytosol, extracellular exosome, lamellipodium
Pathways: Disease, ErbB1 downstream signaling, FCGR3A-mediated phagocytosis, Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania phagocytosis, PDGFR-beta signaling pathway, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), RAC1 GTPase cycle, RAC1 signaling pathway, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: Q8WUW1
Entrez ID: 55845
|
Does Knockout of CCM2L in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 1
| 1,480
|
Knockout
|
CCM2L
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: CCM2L (CCM2 like scaffold protein)
Type: protein-coding
Summary: Predicted to act upstream of or within several processes, including heart development; negative regulation of homotypic cell-cell adhesion; and positive regulation of fibroblast growth factor production. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: biological_process, heart morphogenesis; MF: molecular_function, protein binding
Pathways:
UniProt: Q9NUG4
Entrez ID: 140706
|
Does Knockout of EP400 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
EP400
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: EP400 (E1A binding protein p400)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP binding activity; ATP-dependent chromatin remodeler activity; and protein antigen binding activity. Involved in histone H2A acetylation and histone H4 acetylation. Part of NuA4 histone acetyltransferase complex and Swr1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA repair, chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair; MF: ATP binding, DNA binding, chromatin binding, helicase activity, hydrolase activity, nucleotide binding, protein antigen binding, protein binding; CC: NuA4 histone acetyltransferase complex, Swr1 complex, nuclear speck, nucleoplasm, nucleosome, nucleus
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, DNA Damage/Telomere Stress Induced Senescence, Formation of Senescence-Associated Heterochromatin Foci (SAHF), HATs acetylate histones
UniProt: Q96L91
Entrez ID: 57634
|
Does Knockout of FAM200A in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
FAM200A
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: FAM200A (family with sequence similarity 200 member A)
Type: protein-coding
Summary: This gene encodes a protein of unknown function. The protein is weakly similar to transposase-like proteins in human and mouse. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways:
UniProt: Q8TCP9
Entrez ID: 221786
|
Does Knockout of GNG4 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
GNG4
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: GNG4 (G protein subunit gamma 4)
Type: protein-coding
Summary: Predicted to enable G-protein beta-subunit binding activity. Involved in negative regulation of cell growth. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, negative regulation of cell growth, regulation of G protein-coupled receptor signaling pathway, signal transduction; MF: G-protein beta-subunit binding, protein binding; CC: extracellular exosome, heterotrimeric G-protein complex, membrane, plasma membrane, synapse
Pathways: ADORA2B mediated anti-inflammatory cytokines production, ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of G protein gated Potassium channels, Activation of GABAB receptors, Activation of kainate receptors upon glutamate binding, Adrenaline,noradrenaline inhibits insulin secretion, Alcoholism - Homo sapiens (human), Anti-inflammatory response favouring Leishmania parasite infection, Apelin signaling pathway - Homo sapiens (human), Aquaporin-mediated transport, Beta-catenin independent WNT signaling, Ca2+ pathway, Calcium Regulation in the Cardiac Cell, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chaperonin-mediated protein folding, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Class B/2 (Secretin family receptors), Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Disease, Dopaminergic synapse - Homo sapiens (human), ESR-mediated signaling, Extra-nuclear estrogen signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, G Protein Signaling Pathways, G alpha (12/13) signalling events, G alpha (i) signalling events, G alpha (q) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G beta:gamma signalling through BTK, G beta:gamma signalling through CDC42, G beta:gamma signalling through PI3Kgamma, G beta:gamma signalling through PLC beta, G protein gated Potassium channels, G-protein activation, G-protein beta:gamma signalling, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Homo sapiens (human), GPCR downstream signalling, GPCR ligand binding, GPER1 signaling, Glucagon signaling in metabolic regulation, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Glutamatergic synapse - Homo sapiens (human), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Infectious disease, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Integration of energy metabolism, Inwardly rectifying K+ channels, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Leishmania infection, Leishmania parasite growth and survival, Metabolism, Metabolism of proteins, Morphine addiction - Homo sapiens (human), Myometrial relaxation and contraction pathways, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parasitic Infection Pathways, Pathways in cancer - Homo sapiens (human), Platelet activation, signaling and aggregation, Platelet homeostasis, Potassium Channels, Presynaptic function of Kainate receptors, Prostacyclin signalling through prostacyclin receptor, Protein folding, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of insulin secretion, Relaxin signaling pathway - Homo sapiens (human), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by WNT, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, Transmission across Chemical Synapses, Transport of small molecules, Vasopressin regulates renal water homeostasis via Aquaporins
UniProt: P50150
Entrez ID: 2786
|
Does Knockout of IMPDH2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
IMPDH2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: IMPDH2 (inosine monophosphate dehydrogenase 2)
Type: protein-coding
Summary: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 'de novo' XMP biosynthetic process, GMP biosynthetic process, GTP biosynthetic process, cellular response to interleukin-4, circadian rhythm, lymphocyte proliferation, purine nucleotide biosynthetic process; MF: DNA binding, IMP dehydrogenase activity, RNA binding, catalytic activity, metal ion binding, nucleotide binding, oxidoreductase activity, protein binding; CC: cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, nucleus, peroxisomal membrane, secretory granule lumen
Pathways: Azathioprine ADME, Disease, Drug ADME, Drug metabolism - other enzymes - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Metabolism, Metabolism of nucleotides, Mycophenolic Acid Metabolism Pathway, Neutrophil degranulation, Nucleotide biosynthesis, Potential therapeutics for SARS, Purine metabolism - Homo sapiens (human), Purine ribonucleoside monophosphate biosynthesis, Rett syndrome causing genes, SARS-CoV Infections, Viral Infection Pathways, guanosine nucleotides <i>de novo</i> biosynthesis, guanosine ribonucleotides <i>de novo</i> biosynthesis, purine nucleotides <i>de novo</i> biosynthesis, purine nucleotides degradation, superpathway of purine nucleotide salvage, urate biosynthesis/inosine 5,-phosphate degradation
UniProt: P12268
Entrez ID: 3615
|
Does Knockout of YAP1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
YAP1
|
cell proliferation
|
Cancer Cell Line
|
Gene: YAP1 (Yes1 associated transcriptional regulator)
Type: protein-coding
Summary: This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: DNA damage response, blastocyst development, bud elongation involved in lung branching, canonical Wnt signaling pathway, canonical glycolysis, cardiac muscle tissue regeneration, cell morphogenesis, cell population proliferation, cellular response to gamma radiation, cellular response to retinoic acid, embryonic heart tube morphogenesis, enterocyte differentiation, epithelial cell differentiation, epithelial cell proliferation, extrinsic apoptotic signaling pathway, glandular epithelial cell differentiation, heart process, hippo signaling, interleukin-6-mediated signaling pathway, intestinal epithelial cell development, intestinal epithelial cell differentiation, keratinocyte differentiation, lateral mesoderm development, lung epithelial cell differentiation, negative regulation of cilium assembly, negative regulation of epithelial cell apoptotic process, negative regulation of epithelial cell differentiation, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of fat cell differentiation, negative regulation of gene expression, negative regulation of stem cell differentiation, negative regulation of transcription by RNA polymerase II, notochord development, organ growth, paraxial mesoderm development, polarized epithelial cell differentiation, positive regulation of DNA-templated transcription, positive regulation of Notch signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of cardiac muscle cell proliferation, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, positive regulation of gene expression, positive regulation of organ growth, positive regulation of osteoblast differentiation, positive regulation of protein localization to nucleus, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, protein-containing complex assembly, regulation of canonical Wnt signaling pathway, regulation of cell population proliferation, regulation of gene expression, regulation of keratinocyte proliferation, regulation of metanephric nephron tubule epithelial cell differentiation, regulation of neurogenesis, regulation of stem cell proliferation, response to progesterone, somatic stem cell population maintenance, tissue homeostasis, trophectodermal cell differentiation, vasculogenesis, wound healing; MF: DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, proline-rich region binding, protein binding, transcription cis-regulatory region binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity; CC: TEAD-YAP complex, anchoring junction, bicellular tight junction, cell junction, cell-cell junction, cytoplasm, cytosol, female germ cell nucleus, membrane, mitochondrion, nucleoplasm, nucleus, plasma membrane, transcription regulator complex
Pathways: Adaptive Immune System, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Ciliary landscape, Co-inhibition by PD-1, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Cell Lineages of the Integumentary System, Developmental Lineage of Pancreatic Ductal Cells, Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin, EGR2 and SOX10-mediated initiation of Schwann cell myelination, ErbB4 signaling events, Formation of axial mesoderm, Galanin receptor pathway, Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, Hippo signaling pathway - Homo sapiens (human), Hippo signaling pathway - multiple species - Homo sapiens (human), Immune System, Maternal to zygotic transition (MZT), Mesodermal commitment pathway, Nervous system development, Netrin-UNC5B signaling pathway, Nuclear signaling by ERBB4, Overview of leukocyte-intrinsic Hippo pathway functions, RAC1-PAK1-p38-MMP2 Pathway, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, RUNX2 regulates bone development, RUNX2 regulates osteoblast differentiation, RUNX3 regulates YAP1-mediated transcription, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Response of endothelial cells to shear stress, Signal Transduction, Signaling by ERBB4, Signaling by Hippo, Signaling by Receptor Tyrosine Kinases, TGF-beta Signaling Pathway, TGF-beta receptor signaling, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Validated transcriptional targets of deltaNp63 isoforms, YAP1- and WWTR1 (TAZ)-stimulated gene expression, Zygotic genome activation (ZGA), miR-509-3p alteration of YAP1-ECM axis, p73 transcription factor network
UniProt: P46937
Entrez ID: 10413
|
Does Knockout of UROS in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
UROS
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: UROS (uroporphyrinogen III synthase)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to amine stimulus, cellular response to arsenic-containing substance, heme A biosynthetic process, heme B biosynthetic process, heme O biosynthetic process, heme biosynthetic process, porphyrin-containing compound biosynthetic process, protoporphyrinogen IX biosynthetic process, response to platinum ion, tetrapyrrole biosynthetic process, uroporphyrinogen III biosynthetic process; MF: folic acid binding, lyase activity, uroporphyrinogen-III synthase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Acute Intermittent Porphyria, Congenital Erythropoietic Porphyria (CEP) or Gunther Disease, Heme Biosynthesis, Heme biosynthesis, Hereditary Coproporphyria (HCP), Metabolism, Metabolism of porphyrins, Porphyria Variegata (PV), Porphyrin Metabolism, Porphyrin and chlorophyll metabolism - Homo sapiens (human), heme biosynthesis, hemoglobins chaperone, tetrapyrrole biosynthesis
UniProt: P10746
Entrez ID: 7390
|
Does Knockout of TRAPPC1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
TRAPPC1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: TRAPPC1 (trafficking protein particle complex subunit 1)
Type: protein-coding
Summary: This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, azurophil granule lumen, cytoplasm, cytosol, endoplasmic reticulum, extracellular region
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9Y5R8
Entrez ID: 58485
|
Does Knockout of THEM4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
THEM4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: THEM4 (thioesterase superfamily member 4)
Type: protein-coding
Summary: Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, fatty acid metabolic process, lipid metabolic process, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of mitochondrial membrane permeability involved in apoptotic process, small molecule metabolic process; MF: hydrolase activity, long-chain fatty acyl-CoA hydrolase activity, protein binding; CC: cell projection, cytoplasm, cytosol, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix, mitochondrion, plasma membrane, ruffle membrane
Pathways: Activation of AKT2, Adaptive Immune System, CD28 dependent PI3K/Akt signaling, Co-stimulation by CD28, Fatty acid elongation - Homo sapiens (human), Fatty acid metabolism, IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Insulin receptor signalling cascade, Intracellular signaling by second messengers, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, Negative regulation of the PI3K/AKT network, PI3K Cascade, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PIP3 activates AKT signaling, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by VEGF, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability
UniProt: Q5T1C6
Entrez ID: 117145
|
Does Knockout of RAB10 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
RAB10
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: RAB10 (RAB10, member RAS oncogene family)
Type: protein-coding
Summary: RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009].
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi to plasma membrane transport, antigen processing and presentation, axonogenesis, cell-cell adhesion, cellular response to insulin stimulus, endoplasmic reticulum tubular network organization, endosomal transport, establishment of neuroblast polarity, establishment of protein localization to endoplasmic reticulum membrane, establishment of protein localization to membrane, exocytosis, polarized epithelial cell differentiation, protein localization to basolateral plasma membrane, protein localization to plasma membrane, protein transport, regulated exocytosis, vesicle-mediated transport; MF: G protein activity, GDP binding, GTP binding, GTPase activity, cadherin binding involved in cell-cell adhesion, hydrolase activity, myosin V binding, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi membrane, adherens junction, cell projection, cilium, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, endosome, endosome membrane, exocyst, exocytic vesicle, extracellular exosome, focal adhesion, insulin-responsive compartment, lysosome, membrane, perinuclear region of cytoplasm, phagocytic vesicle membrane, plasma membrane, recycling endosome, recycling endosome membrane, secretory granule membrane, secretory vesicle, trans-Golgi network
Pathways: AMPK signaling pathway - Homo sapiens (human), Endocytosis - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Translocation of SLC2A4 (GLUT4) to the plasma membrane, Vesicle-mediated transport
UniProt: P61026
Entrez ID: 10890
|
Does Knockout of CELF6 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
CELF6
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: CELF6 (CUGBP Elav-like family member 6)
Type: protein-coding
Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010].
Gene Ontology: BP: mRNA processing, mRNA splice site recognition, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding; CC: cytoplasm, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q96J87
Entrez ID: 60677
|
Does Knockout of VPS16 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
VPS16
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: VPS16 (VPS16 core subunit of CORVET and HOPS complexes)
Type: protein-coding
Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: autophagosome maturation, autophagy, endosomal transport, endosomal vesicle fusion, endosome to lysosome transport, intracellular protein transport, protein transport, regulation of SNARE complex assembly, vacuole fusion, non-autophagic, vacuole organization; MF: actin binding, actin filament binding, protein binding; CC: CORVET complex, HOPS complex, autophagosome, axon, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, early endosome, endosome, endosome membrane, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, neuronal cell body, presynapse, recycling endosome, vesicle tethering complex
Pathways: Alpha4 beta1 integrin signaling events, Disease, EGFR1, Ebola Virus Pathway on Host, Infectious disease, Insulin Pathway, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates autophagy, SARS-CoV-2-host interactions, Salmonella infection - Homo sapiens (human), TCR, Viral Infection Pathways
UniProt: Q9H269
Entrez ID: 64601
|
Does Knockout of APOC4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
APOC4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: APOC4 (apolipoprotein C4)
Type: protein-coding
Summary: This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011].
Gene Ontology: BP: lipid metabolic process, lipid storage, lipid transport, triglyceride homeostasis; MF: lipid transporter activity, protein binding; CC: extracellular region, high-density lipoprotein particle, very-low-density lipoprotein particle
Pathways: NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Signal Transduction, Signaling by Nuclear Receptors, Transport of small molecules, VLDL assembly, VLDL clearance
UniProt: P55056
Entrez ID: 346
|
Does Knockout of ADCY1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
ADCY1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: ADCY1 (adenylate cyclase 1)
Type: protein-coding
Summary: This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: adenylate cyclase-activating G protein-coupled receptor signaling pathway, axonogenesis, cAMP biosynthetic process, cellular response to calcium ion, cellular response to forskolin, cyclic nucleotide biosynthetic process, intracellular signal transduction, long-term memory, modulation of chemical synaptic transmission, neuroinflammatory response, positive regulation of CREB transcription factor activity, positive regulation of long-term synaptic potentiation, presynaptic modulation of chemical synaptic transmission, regulation of circadian rhythm, rhythmic process; MF: ATP binding, adenylate cyclase activity, calcium- and calmodulin-responsive adenylate cyclase activity, calmodulin binding, lyase activity, metal ion binding, nucleotide binding, phosphorus-oxygen lyase activity; CC: Schaffer collateral - CA1 synapse, cytoplasm, extracellular exosome, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane, membrane raft, plasma membrane, postsynaptic density, postsynaptic density membrane, presynapse
Pathways: ADORA2B mediated anti-inflammatory cytokines production, Activation of GABAB receptors, Activation of NMDA receptors and postsynaptic events, Adenylate cyclase activating pathway, Adenylate cyclase inhibitory pathway, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Amoebiasis - Homo sapiens (human), Anti-inflammatory response favouring Leishmania parasite infection, Apelin signaling pathway - Homo sapiens (human), Aquaporin-mediated transport, BDNF-TrkB Signaling, Bile secretion - Homo sapiens (human), CREB1 phosphorylation through the activation of Adenylate Cyclase, Ca-dependent events, CaM pathway, Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Calmodulin induced events, Cannabinoid receptor signaling, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chagas disease - Homo sapiens (human), Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Common Pathways Underlying Drug Addiction, Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), DAG and IP3 signaling, Dilated cardiomyopathy - Homo sapiens (human), Disease, Endothelins, Envelope proteins and their potential roles in EDMD physiopathology, Estrogen signaling pathway - Homo sapiens (human), FCGR3A-mediated IL10 synthesis, G Protein Signaling Pathways, G alpha (i) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G-protein mediated events, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Homo sapiens (human), GPCR downstream signalling, GPER1 signaling, Gap junction - Homo sapiens (human), Gastric acid secretion - Homo sapiens (human), Glucagon signaling in metabolic regulation, Glutamatergic synapse - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hedgehog 'off' state, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Infectious disease, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Integration of energy metabolism, Intracellular signaling by second messengers, LPA receptor mediated events, LPA4-mediated signaling events, Leishmania infection, Leishmania parasite growth and survival, Long-term potentiation - Homo sapiens (human), Longevity regulating pathway - Homo sapiens (human), Longevity regulating pathway - multiple species - Homo sapiens (human), Melanogenesis - Homo sapiens (human), Metabolism, Morphine addiction - Homo sapiens (human), Myometrial relaxation and contraction pathways, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Oocyte meiosis - Homo sapiens (human), Opioid Signalling, Ovarian steroidogenesis - Homo sapiens (human), Oxytocin signaling pathway - Homo sapiens (human), PKA activation, PKA activation in glucagon signalling, PKA-mediated phosphorylation of CREB, PLC beta mediated events, Pancreatic secretion - Homo sapiens (human), Parasitic Infection Pathways, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Phosphodiesterases in neuronal function, Phospholipase D signaling pathway - Homo sapiens (human), Platelet activation - Homo sapiens (human), Post NMDA receptor activation events, Progesterone-mediated oocyte maturation - Homo sapiens (human), Purine metabolism - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Regulation of lipolysis in adipocytes - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Homo sapiens (human), Salivary secretion - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Signaling by Hedgehog, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormone synthesis - Homo sapiens (human), Transmission across Chemical Synapses, Transport of small molecules, Vascular smooth muscle contraction - Homo sapiens (human), Vasopressin regulates renal water homeostasis via Aquaporins, activation of camp-dependent protein kinase pka, activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor, cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human), chrebp regulation by carbohydrates and camp, cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway, gata3 participate in activating the th2 cytokine genes expression, how progesterone initiates the oocyte maturation, ion channels and their functional role in vascular endothelium, phospholipids as signalling intermediaries, regulation of bad phosphorylation, regulation of ck1/cdk5 by type 1 glutamate receptors, regulation of spermatogenesis by crem, thrombin signaling and protease-activated receptors
UniProt: Q08828
Entrez ID: 107
|
Does Knockout of POLD2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
POLD2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: POLD2 (DNA polymerase delta 2, accessory subunit)
Type: protein-coding
Summary: This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA-templated DNA replication, error-prone translesion synthesis; MF: DNA binding, protein binding; CC: delta DNA polymerase complex, nucleoplasm, nucleus, zeta DNA polymerase complex
Pathways: Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Pyrimidine metabolism, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P49005
Entrez ID: 5425
|
Does Knockout of ZPR1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
ZPR1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ZPR1 (ZPR1 zinc finger)
Type: protein-coding
Summary: The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: Cajal body organization, DNA endoreduplication, DNA replication, RNA splicing, apoptotic process involved in development, axon development, cell differentiation, cellular response to epidermal growth factor stimulus, inner cell mass cell proliferation, mRNA processing, microtubule cytoskeleton organization, negative regulation of motor neuron apoptotic process, positive regulation of RNA splicing, positive regulation of cell cycle, positive regulation of gene expression, positive regulation of growth, positive regulation of protein import into nucleus, pre-mRNA catabolic process, protein folding, regulation of myelination, signal transduction, spinal cord development, trophectodermal cell proliferation; MF: metal ion binding, protein binding, protein folding chaperone, receptor tyrosine kinase binding, translation initiation factor binding, zinc ion binding; CC: Cajal body, Gemini of Cajal bodies, axon, cell projection, cytoplasm, growth cone, neuronal cell body, nucleolus, nucleoplasm, nucleus, perikaryon, perinuclear region of cytoplasm
Pathways: EGFR1
UniProt: O75312
Entrez ID: 8882
|
Does Knockout of RANBP17 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
RANBP17
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: RANBP17 (RAN binding protein 17)
Type: protein-coding
Summary: The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002].
Gene Ontology: BP: intracellular protein transport, mRNA transport, nuclear transport, nucleocytoplasmic transport, protein export from nucleus, protein import into nucleus, protein transport; MF: GTP binding, nuclear export signal receptor activity, small GTPase binding; CC: cytoplasm, nuclear pore, nucleus
Pathways:
UniProt: Q9H2T7
Entrez ID: 64901
|
Does Knockout of IGHV3-7 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
IGHV3-7
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: IGHV3-7 (immunoglobulin heavy variable 3-7)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of BRCA1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
BRCA1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: BRCA1 (BRCA1 DNA repair associated)
Type: protein-coding
Summary: This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA strand resection involved in replication fork processing, cellular response to indole-3-methanol, cellular response to ionizing radiation, cellular response to tumor necrosis factor, centrosome cycle, chordate embryonic development, chromatin remodeling, chromosome segregation, double-strand break repair, double-strand break repair via homologous recombination, fatty acid biosynthetic process, fatty acid metabolic process, homologous recombination, intrinsic apoptotic signaling pathway in response to DNA damage, lipid metabolic process, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, negative regulation of DNA-templated transcription, negative regulation of cell cycle, negative regulation of cell growth, negative regulation of centriole replication, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of fatty acid biosynthetic process, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of reactive oxygen species metabolic process, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of angiogenesis, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial growth factor production, postreplication repair, protein K6-linked ubiquitination, protein autoubiquitination, protein ubiquitination, random inactivation of X chromosome, regulation of DNA damage checkpoint, regulation of DNA repair, regulation of cell cycle, regulation of transcription by RNA polymerase II, response to ionizing radiation, sex-chromosome dosage compensation; MF: DNA binding, RNA binding, RNA polymerase binding, damaged DNA binding, enzyme binding, histone H2AK127 ubiquitin ligase activity, histone H2AK129 ubiquitin ligase activity, identical protein binding, metal ion binding, p53 binding, protein binding, transcription cis-regulatory region binding, transcription coactivator activity, transferase activity, tubulin binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-modified histone reader activity, ubiquitin-protein transferase activity, zinc ion binding; CC: BRCA1-A complex, BRCA1-B complex, BRCA1-BARD1 complex, BRCA1-C complex, DNA repair complex, XY body, chromosome, condensed chromosome, condensed nuclear chromosome, cytoplasm, gamma-tubulin ring complex, lateral element, male germ cell nucleus, nuclear body, nuclear ubiquitin ligase complex, nucleoplasm, nucleus, plasma membrane, protein-containing complex, ribonucleoprotein complex, ubiquitin ligase complex
Pathways: ATF-2 transcription factor network, ATM pathway, Androgen receptor signaling pathway, AndrogenReceptor, Aurora A signaling, BARD1 signaling events, Breast cancer - Homo sapiens (human), Breast cancer pathway, Coregulation of Androgen receptor activity, DNA Repair Pathways Full Network, DNA damage response, E2F transcription factor network, FOXA1 transcription factor network, Fanconi anemia pathway, Fanconi anemia pathway - Homo sapiens (human), Glioblastoma signaling pathways, Hepatitis C and Hepatocellular Carcinoma, Homologous recombination - Homo sapiens (human), MicroRNAs in cancer - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways affected in adenoid cystic carcinoma, TGF_beta_Receptor, Ubiquitin mediated proteolysis - Homo sapiens (human), Validated nuclear estrogen receptor alpha network, Validated targets of C-MYC transcriptional repression, atm signaling pathway, brca1 dependent ub ligase activity, cell cycle: g2/m checkpoint, miRNA regulation of DNA damage response, role of brca1 brca2 and atr in cancer susceptibility
UniProt: P38398
Entrez ID: 672
|
Does Knockout of CAST in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
CAST
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CAST (calpastatin)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of ZNF208 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
ZNF208
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ZNF208 (zinc finger protein 208)
Type: protein-coding
Summary: Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009].
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: O43345
Entrez ID: 7757
|
Does Knockout of TCERG1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
TCERG1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: TCERG1 (transcription elongation regulator 1)
Type: protein-coding
Summary: This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA processing, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II; MF: RNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, RNA polymerase binding, identical protein binding, protein binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity, transcription elongation factor activity, ubiquitin-like protein conjugating enzyme binding; CC: nuclear speck, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O14776
Entrez ID: 10915
|
Does Knockout of NECTIN1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
NECTIN1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: NECTIN1 (nectin cell adhesion molecule 1)
Type: protein-coding
Summary: This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: axon guidance, camera-type eye morphogenesis, cell adhesion, cell-cell adhesion, cochlea morphogenesis, desmosome organization, enamel mineralization, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, immune response, iron ion transport, lens morphogenesis in camera-type eye, protein localization to cell junction, regulation of synapse assembly, regulation of synapse organization, retina development in camera-type eye, symbiont entry into host cell; MF: carbohydrate binding, cell adhesion mediator activity, cell adhesion molecule binding, coreceptor activity, identical protein binding, protein binding, protein homodimerization activity, protein-containing complex binding, signaling receptor activity, virion binding, virus receptor activity; CC: adherens junction, anchoring junction, apical junction complex, axon, cell projection, cell-cell contact zone, dendrite, extracellular region, growth cone membrane, hippocampal mossy fiber to CA3 synapse, membrane, plasma membrane, presynaptic active zone membrane, presynaptic membrane, synapse
Pathways: Adherens junction - Homo sapiens (human), Adherens junctions interactions, Cell adhesion molecules - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, EGFR1, Herpes simplex virus 1 infection - Homo sapiens (human), Nectin adhesion pathway, Nectin/Necl trans heterodimerization
UniProt: Q15223
Entrez ID: 5818
|
Does Knockout of PIP4K2C in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
PIP4K2C
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma)
Type: protein-coding
Summary: Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and identical protein binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity; and positive regulation of autophagosome assembly. Located in several cellular components, including autophagosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process, lipid metabolic process, negative regulation of insulin receptor signaling pathway, phosphatidylinositol metabolic process, phosphatidylinositol phosphate biosynthetic process, positive regulation of autophagosome assembly, regulation of autophagy; MF: 1-phosphatidylinositol-4-phosphate 5-kinase activity, 1-phosphatidylinositol-5-phosphate 4-kinase activity, ATP binding, identical protein binding, kinase activity, nucleotide binding, phosphatidylinositol kinase activity, protein binding, transferase activity; CC: autophagosome, cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, intracellular membrane-bounded organelle, nucleoplasm, plasma membrane
Pathways: BCR, D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, D-<i>myo</i>-inositol-5-phosphate metabolism, Gene expression (Transcription), Generic Transcription Pathway, Inositol phosphate metabolism - Homo sapiens (human), Intracellular signaling by second messengers, Metabolism, Metabolism of lipids, Negative regulation of the PI3K/AKT network, PI Metabolism, PI5P Regulates TP53 Acetylation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipid metabolism, RNA Polymerase II Transcription, Regulation of Actin Cytoskeleton, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of actin cytoskeleton - Homo sapiens (human), Signal Transduction, Synthesis of PIPs at the plasma membrane, Synthesis of PIPs in the nucleus, Transcriptional Regulation by TP53, superpathway of inositol phosphate compounds
UniProt: Q8TBX8
Entrez ID: 79837
|
Does Knockout of DCLRE1A in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
DCLRE1A
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: DCLRE1A (DNA cross-link repair 1A)
Type: protein-coding
Summary: This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: DNA damage response, DNA repair, cell division, double-strand break repair via nonhomologous end joining, interstrand cross-link repair; MF: 5'-3' DNA exonuclease activity, DNA binding, beta-lactamase activity, damaged DNA binding, hydrolase activity, metal ion binding, zinc ion binding; CC: fibrillar center, nucleoplasm, nucleus
Pathways: DNA Repair, Fanconi Anemia Pathway
UniProt: Q6PJP8
Entrez ID: 9937
|
Does Knockout of SAMD7 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
SAMD7
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: SAMD7 (sterile alpha motif domain containing 7)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, retinal rod cell development; MF: DNA-binding transcription repressor activity, RNA polymerase II-specific, chromatin binding, histone binding, protein binding; CC: PRC1 complex, cytoplasm, nucleus
Pathways:
UniProt: Q7Z3H4
Entrez ID: 344658
|
Does Knockout of CELA2B in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
CELA2B
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: CELA2B (chymotrypsin like elastase 2B)
Type: protein-coding
Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region, extracellular space
Pathways: Pancreatic secretion - Homo sapiens (human), Protein digestion and absorption - Homo sapiens (human)
UniProt: P08218
Entrez ID: 51032
|
Does Knockout of CTR9 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
CTR9
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CTR9 (CTR9 component of Paf1/RNA polymerase II complex)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the PAF1 complex, which associates with RNA polymerase II and functions in transcriptional regulation and elongation. This complex also plays a role in the modification of histones. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: Wnt signaling pathway, blastocyst growth, blastocyst hatching, cell surface receptor signaling pathway via JAK-STAT, cellular response to lipopolysaccharide, chromatin organization, endodermal cell fate commitment, inner cell mass cell differentiation, interleukin-6-mediated signaling pathway, negative regulation of gene expression, epigenetic, negative regulation of myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II, trophectodermal cell differentiation; MF: RNA polymerase II complex binding, SH2 domain binding, protein binding; CC: Cdc73/Paf1 complex, euchromatin, nuclear speck, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Endoderm differentiation, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q6PD62
Entrez ID: 9646
|
Does Knockout of RUVBL1 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
RUVBL1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: RUVBL1 (RuvB like AAA ATPase 1)
Type: protein-coding
Summary: This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, box C/D snoRNP assembly, cell division, chromatin organization, chromatin remodeling, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of canonical Wnt signaling pathway, positive regulation of double-strand break repair via homologous recombination, positive regulation of telomere maintenance in response to DNA damage, protein stabilization, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of chromosome organization, regulation of double-strand break repair, regulation of embryonic development, regulation of transcription by RNA polymerase II, spermatogenesis, telomerase RNA localization to Cajal body, telomere maintenance; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATPase binding, DNA helicase activity, TBP-class protein binding, TFIID-class transcription factor complex binding, cadherin binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, transcription coactivator activity; CC: Ino80 complex, MLL1 complex, NuA4 histone acetyltransferase complex, R2TP complex, RPAP3/R2TP/prefoldin-like complex, Swr1 complex, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, dynein axonemal particle, extracellular exosome, membrane, nuclear matrix, nuclear speck, nucleoplasm, nucleosome, nucleus, protein folding chaperone complex, ribonucleoprotein complex
Pathways: C-MYC pathway, Cell Cycle, Chromatin modifying enzymes, Chromatin organization, Chromosome Maintenance, DNA Damage Recognition in GG-NER, DNA Repair, Deposition of new CENPA-containing nucleosomes at the centromere, Deubiquitination, Extension of Telomeres, Formation of the beta-catenin:TCF transactivating complex, Gastric Cancer Network 1, Global Genome Nucleotide Excision Repair (GG-NER), HATs acetylate histones, Integrin-linked kinase signaling, LncRNA involvement in canonical Wnt signaling and colorectal cancer, Metabolism of proteins, Nucleosome assembly, Nucleotide Excision Repair, Post-translational protein modification, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Telomere Extension By Telomerase, Telomere Maintenance, UCH proteinases, Ub-specific processing proteases, Validated targets of C-MYC transcriptional activation, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q9Y265
Entrez ID: 8607
|
Does Knockout of MUC19 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
MUC19
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: MUC19 (mucin 19, oligomeric (gene/pseudogene))
Type: protein-coding
Summary: This gene encodes a member of the gel-forming mucin protein family. Mucin family members are glycoproteins that have tandem repeats which are extensively O-glycosylated. The structural features of mucin proteins are responsible for the gel-like properties of mucus. The encoded protein may be involved in disruption of the ocular surface in Sjogren syndrome. [provided by RefSeq, Apr 2014].
Gene Ontology: CC: Golgi lumen, endomembrane system, extracellular region, plasma membrane
Pathways: C-type lectin receptors (CLRs), Dectin-2 family, Defective C1GALT1C1 causes TNPS, Defective GALNT12 causes CRCS1, Defective GALNT3 causes HFTC, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Immune System, Innate Immune System, Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, Termination of O-glycan biosynthesis
UniProt: Q7Z5P9
Entrez ID: 283463
|
Does Knockout of HADH in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
HADH
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: HADH (hydroxyacyl-CoA dehydrogenase)
Type: protein-coding
Summary: This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010].
Gene Ontology: BP: cell differentiation, fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process, negative regulation of insulin secretion, positive regulation of cold-induced thermogenesis, regulation of insulin secretion, response to activity, response to hormone, response to insulin, response to xenobiotic stimulus, spermatogenesis; MF: (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity, NAD+ binding, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, transferase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways: 2-aminoadipic 2-oxoadipic aciduria, Amino Acid metabolism, Beta oxidation of butanoyl-CoA to acetyl-CoA, Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA, Beta oxidation of hexanoyl-CoA to butanoyl-CoA, Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA, Beta oxidation of octanoyl-CoA to hexanoyl-CoA, Butanoate metabolism - Homo sapiens (human), Butyrate Metabolism, FOXA2 and FOXA3 transcription factor networks, Fatty Acid Biosynthesis, Fatty acid beta-oxidation, Fatty acid degradation - Homo sapiens (human), Fatty acid elongation - Homo sapiens (human), Fatty acid metabolism, Glutaric Aciduria Type I, Hyperlysinemia I, Familial, Hyperlysinemia II or Saccharopinuria, IL-18 signaling pathway, Lysine Degradation, Lysine degradation - Homo sapiens (human), Metabolism, Metabolism of lipids, Metabolism of proteins, Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids, Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids, Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids, Mitochondrial Fatty Acid Beta-Oxidation, Mitochondrial LC-Fatty Acid Beta-Oxidation, Mitochondrial protein degradation, Pyridoxine dependency with seizures, Saccharopinuria/Hyperlysinemia II, Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (SCHAD), Tryptophan metabolism, Tryptophan metabolism - Homo sapiens (human), Valine, leucine and isoleucine degradation - Homo sapiens (human), fatty acid β-oxidation, fatty acid β-oxidation (peroxisome), mitochondrial fatty acid beta-oxidation of saturated fatty acids
UniProt: Q16836
Entrez ID: 3033
|
Does Knockout of ORAI3 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
ORAI3
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: ORAI3 (ORAI calcium release-activated calcium modulator 3)
Type: protein-coding
Summary: Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, store-operated calcium entry; MF: calcium channel activity, protein binding, store-operated calcium channel activity; CC: membrane, plasma membrane
Pathways: Calcium signaling pathway - Homo sapiens (human)
UniProt: Q9BRQ5
Entrez ID: 93129
|
Does Knockout of S100A12 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
S100A12
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: S100A12 (S100 calcium binding protein A12)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, defense response to bacterium, defense response to fungus, endothelial cell migration, immune system process, inflammatory response, innate immune response, killing of cells of another organism, mast cell activation, monocyte chemotaxis, neutrophil chemotaxis, positive regulation of MAP kinase activity, positive regulation of NF-kappaB transcription factor activity, positive regulation of canonical NF-kappaB signal transduction, positive regulation of inflammatory response, xenobiotic metabolic process; MF: RAGE receptor binding, calcium ion binding, calcium-dependent protein binding, copper ion binding, identical protein binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytoskeleton, cytosol, extracellular region, membrane, nucleus, plasma membrane, secretory granule lumen
Pathways: Advanced glycosylation endproduct receptor signaling, Cytokine Signaling in Immune system, DDX58/IFIH1-mediated induction of interferon-alpha/beta, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Neutrophil degranulation, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated NF-kB activation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: P80511
Entrez ID: 6283
|
Does Knockout of ZNF76 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
ZNF76
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: ZNF76 (zinc finger protein 76)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase III; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: 3q29 copy number variation syndrome
UniProt: P36508
Entrez ID: 7629
|
Does Knockout of HPR in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
HPR
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: HPR (haptoglobin-related protein)
Type: protein-coding
Summary: This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011].
Gene Ontology: MF: hemoglobin binding, serine-type endopeptidase activity; CC: blood microparticle, extracellular exosome, extracellular region, extracellular space, spherical high-density lipoprotein particle
Pathways: African trypanosomiasis - Homo sapiens (human), Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport
UniProt: P00739
Entrez ID: 3250
|
Does Knockout of VEGFC in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
VEGFC
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: VEGFC (vascular endothelial growth factor C)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: angiogenesis, animal organ morphogenesis, cell differentiation, cell population proliferation, cellular response to leukemia inhibitory factor, glial cell proliferation, induction of positive chemotaxis, morphogenesis of embryonic epithelium, negative regulation of blood pressure, negative regulation of osteoblast differentiation, positive chemotaxis, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of cell division, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, positive regulation of glial cell proliferation, positive regulation of lymphangiogenesis, positive regulation of mast cell chemotaxis, positive regulation of mesenchymal stem cell proliferation, positive regulation of neuroblast proliferation, positive regulation of protein secretion, regulation of vascular endothelial growth factor receptor signaling pathway, response to hypoxia, response to xenobiotic stimulus, signal transduction, sprouting angiogenesis, substrate-dependent cell migration, vascular endothelial growth factor receptor signaling pathway, vascular endothelial growth factor signaling pathway; MF: chemoattractant activity, growth factor activity, protein binding, receptor ligand activity, vascular endothelial growth factor receptor 3 binding; CC: extracellular region, extracellular space, membrane, platelet alpha granule lumen
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Alpha9 beta1 integrin signaling events, Calcium signaling pathway - Homo sapiens (human), Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Heart Development, Hemostasis, MAPK signaling pathway - Homo sapiens (human), MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Platelet activation, signaling and aggregation, Platelet degranulation , Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Response to elevated platelet cytosolic Ca2+, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, TNF signaling pathway - Homo sapiens (human), VEGF and VEGFR signaling network, VEGF binds to VEGFR leading to receptor dimerization, VEGF ligand-receptor interactions, VEGFR3 signaling in lymphatic endothelium
UniProt: P49767
Entrez ID: 7424
|
Does Knockout of MAMDC4 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
MAMDC4
|
response to virus
|
Hepatoma Cell Line
|
Gene: MAMDC4 (MAM domain containing 4)
Type: protein-coding
Summary: Predicted to be involved in protein transport. Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: nervous system development, protein transport
Pathways:
UniProt: Q6UXC1
Entrez ID: 158056
|
Does Knockout of RCC1L in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
RCC1L
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RCC1L (RCC1 like)
Type: protein-coding
Summary: This gene encodes a protein containing regulator of chromosome condensation 1-like repeats. The encoded protein may function as a guanine nucleotide exchange factor. This gene is located in a region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: mitochondrial fusion, mitochondrial large ribosomal subunit assembly, mitochondrial small ribosomal subunit assembly; MF: GTP binding, RNA binding, guanyl-nucleotide exchange factor activity, nucleotide binding, protein binding, rRNA binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion
Pathways: Metabolism of RNA, Mitochondrial mRNA modification, rRNA modification in the mitochondrion, rRNA processing, rRNA processing in the mitochondrion
UniProt: Q96I51
Entrez ID: 81554
|
Does Knockout of UFD1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
UFD1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: UFD1 (ubiquitin recognition factor in ER associated degradation 1)
Type: protein-coding
Summary: The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: ERAD pathway, cellular response to misfolded protein, negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, proteasome-mediated ubiquitin-dependent protein catabolic process, retrograde protein transport, ER to cytosol, skeletal system development, ubiquitin-dependent protein catabolic process; MF: K48-linked polyubiquitin modification-dependent protein binding, cysteine-type deubiquitinase activity, polyubiquitin modification-dependent protein binding, protein binding; CC: UFD1-NPL4 complex, VCP-NPL4-UFD1 AAA ATPase complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: 22q11.2 copy number variation syndrome, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, DNA Damage Bypass, DNA Repair, Deubiquitination, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Translation, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Ub-specific processing proteases
UniProt: Q92890
Entrez ID: 7353
|
Does Knockout of SUPT6H in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
SUPT6H
|
cell proliferation
|
Bladder Carcinoma
|
Gene: SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor)
Type: protein-coding
Summary: Enables histone binding activity. Involved in negative regulation of histone H3-K27 methylation and positive regulation of transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. Predicted to be active in transcriptionally active chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, blastocyst formation, mRNA processing, mRNA transport, nucleobase-containing compound metabolic process, nucleosome organization, positive regulation of transcription elongation by RNA polymerase II, regulation of isotype switching, regulation of muscle cell differentiation, transcription elongation by RNA polymerase II, transcription elongation-coupled chromatin remodeling; MF: DNA binding, RNA binding, histone binding, nucleic acid binding, nucleosome binding, protein binding; CC: nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Formation of RNA Pol II elongation complex , Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q7KZ85
Entrez ID: 6830
|
Does Knockout of ADIPOR1 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
ADIPOR1
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: ADIPOR1 (adiponectin receptor 1)
Type: protein-coding
Summary: This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: adiponectin-activated signaling pathway, fatty acid metabolic process, fatty acid oxidation, glucose homeostasis, hormone-mediated signaling pathway, leptin-mediated signaling pathway, lipid metabolic process, negative regulation of cell growth, negative regulation of epithelial cell migration, negative regulation of epithelial to mesenchymal transition, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of receptor signaling pathway via JAK-STAT, positive regulation of cold-induced thermogenesis, positive regulation of insulin receptor signaling pathway, positive regulation of receptor signaling pathway via JAK-STAT, regulation of glucose metabolic process, regulation of lipid metabolic process; MF: adipokinetic hormone receptor activity, adiponectin binding, identical protein binding, metal ion binding, protein binding, protein kinase binding, signaling receptor activity; CC: membrane, plasma membrane
Pathways: AMP-activated protein kinase (AMPK) signaling, AMPK inhibits chREBP transcriptional activation activity, AMPK signaling pathway - Homo sapiens (human), Adipocytokine signaling pathway - Homo sapiens (human), Integration of energy metabolism, Leptin and adiponectin, Longevity regulating pathway - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease
UniProt: Q96A54
Entrez ID: 51094
|
Does Knockout of SEZ6L2 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
SEZ6L2
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: SEZ6L2 (seizure related 6 homolog like 2)
Type: protein-coding
Summary: This gene encodes a seizure-related protein that is localized on the cell surface. The gene is located in a region of chromosome 16p11.2 that is thought to contain candidate genes for autism spectrum disorders (ASD), though there is no evidence directly implicating this gene in ASD. Increased expression of this gene has been found in lung cancers, and the protein is therefore considered to be a novel prognostic marker for lung cancer. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: adult locomotory behavior, cerebellar Purkinje cell layer development, synapse maturation; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, neuronal cell body, plasma membrane
Pathways: 16p11.2 proximal deletion syndrome
UniProt: Q6UXD5
Entrez ID: 26470
|
Does Knockout of PTPRCAP in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
PTPRCAP
|
response to chemicals
|
Melanoma Cell Line
|
Gene: PTPRCAP (protein tyrosine phosphatase receptor type C associated protein)
Type: protein-coding
Summary: The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: membrane, plasma membrane
Pathways: TNF-alpha signaling pathway
UniProt: Q14761
Entrez ID: 5790
|
Does Knockout of TTR in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
TTR
|
response to virus
|
Huh-7 Cell
|
Gene: TTR (transthyretin)
Type: protein-coding
Summary: This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: negative regulation of glomerular filtration, phototransduction, visible light, purine nucleobase metabolic process, retinoid metabolic process; MF: hormone activity, hormone binding, identical protein binding, molecular sequestering activity, protein binding, protein-containing complex binding; CC: azurophil granule lumen, cytoplasm, extracellular exosome, extracellular region, extracellular space, protein-containing complex
Pathways: Amyloid fiber formation, Defective visual phototransduction due to STRA6 loss of function, Disease, Diseases associated with visual transduction, Diseases of the neuronal system, Extracellular matrix organization, FOXA2 and FOXA3 transcription factor networks, Immune System, Innate Immune System, Metabolism, Metabolism of fat-soluble vitamins, Metabolism of proteins, Metabolism of vitamins and cofactors, Neutrophil degranulation, Non-integrin membrane-ECM interactions, Retinoid cycle disease events, Retinoid metabolism and transport, Sensory Perception, The canonical retinoid cycle in rods (twilight vision), Thyroid hormone synthesis - Homo sapiens (human), Visual phototransduction
UniProt: P02766
Entrez ID: 7276
|
Does Knockout of YAF2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
YAF2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: YAF2 (YY1 associated factor 2)
Type: protein-coding
Summary: This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: DNA binding, metal ion binding, protein binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8IY57
Entrez ID: 10138
|
Does Knockout of LUC7L3 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
LUC7L3
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: LUC7L3 (LUC7 like 3 pre-mRNA splicing factor)
Type: protein-coding
Summary: This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splice site recognition; MF: DNA binding, RNA binding, mRNA binding, protein binding; CC: U1 snRNP, U2-type prespliceosome, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: O95232
Entrez ID: 51747
|
Does Knockout of FUT2 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
FUT2
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: FUT2 (fucosyltransferase 2 (H blood group))
Type: protein-coding
Summary: This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. The encoded protein is important for the final step in the soluble ABO blood group antigen synthesis pathway. It is also involved in cell-cell interaction, cell surface expression, and cell proliferation. Mutations in this gene are a cause of the H-Bombay blood group where red blood cells lack the H antigen. [provided by RefSeq, May 2022].
Gene Ontology: BP: L-fucose catabolic process, carbohydrate metabolic process, fucosylation, glycolipid metabolic process, glycosphingolipid biosynthetic process, lipid metabolic process, oligosaccharide biosynthetic process, protein glycosylation, regulation of cell adhesion, regulation of endothelial cell proliferation; MF: alpha-(1,2)-fucosyltransferase activity, fucosyltransferase activity, galactoside 2-alpha-L-fucosyltransferase activity, glycosyltransferase activity, protein binding, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, extracellular exosome, membrane
Pathways: ABO blood group biosynthesis, Blood group systems biosynthesis, Globo Sphingolipid Metabolism, Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - globo and isoglobo series - Homo sapiens (human), Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human), Glycosphingolipid metabolism, Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of lipids, Sphingolipid metabolism
UniProt: Q10981
Entrez ID: 2524
|
Does Knockout of SLC5A4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
SLC5A4
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: SLC5A4 (solute carrier family 5 member 4)
Type: protein-coding
Summary: Predicted to enable glucose:sodium symporter activity and proton transmembrane transporter activity. Predicted to be involved in sodium ion transport. Predicted to act upstream of or within proton transmembrane transport. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: monoatomic ion transport, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: D-glucose:sodium symporter activity, protein binding, solute:sodium symporter activity, transmembrane transporter activity; CC: membrane, plasma membrane
Pathways: Cellular hexose transport, NRF2 pathway, Nuclear Receptors Meta-Pathway, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q9NY91
Entrez ID: 6527
|
Does Knockout of SASS6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
SASS6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SASS6 (SAS-6 centriolar assembly protein)
Type: protein-coding
Summary: The protein encoded by this gene is a central component of centrioles and is necessary for their duplication and function. Centrioles adopt a cartwheel-shaped structure, with the encoded protein forming the hub and spokes inside a microtubule cylinder. Defects in this gene are a cause of autosomal recessive primary microcephaly. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: centriole replication, centrosome duplication, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of centriole replication, positive regulation of spindle assembly, regulation of mitotic spindle organization, spermatogenesis; CC: centriole, centrosome, cytoplasm, cytoskeleton, deuterosome, procentriole replication complex
Pathways: Genes related to primary cilium development (based on CRISPR)
UniProt: Q6UVJ0
Entrez ID: 163786
|
Does Knockout of KAT14 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
KAT14
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: KAT14 (lysine acetyltransferase 14)
Type: protein-coding
Summary: CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: chromatin remodeling, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II; MF: LIM domain binding, acyltransferase activity, transferring groups other than amino-acyl groups, histone acetyltransferase activity, protein binding; CC: ATAC complex, cytoplasm, mitotic spindle, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones
UniProt: Q9H8E8
Entrez ID: 57325
|
Does Knockout of DLG3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
DLG3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: DLG3 (discs large MAGUK scaffold protein 3)
Type: protein-coding
Summary: This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: cell-cell adhesion, chemical synaptic transmission, establishment of planar polarity, establishment or maintenance of epithelial cell apical/basal polarity, negative regulation of cell population proliferation, nervous system development, protein localization to synapse, receptor clustering, receptor localization to synapse, regulation of postsynaptic membrane neurotransmitter receptor levels; MF: ionotropic glutamate receptor binding, kinase binding, phosphatase binding, protein binding, protein kinase binding, ubiquitin protein ligase binding; CC: AMPA glutamate receptor complex, adherens junction, basolateral plasma membrane, bicellular tight junction, cell-cell junction, cytoplasm, cytosol, extracellular space, glutamatergic synapse, neuromuscular junction, neuron projection, plasma membrane, postsynaptic density membrane
Pathways: Activation of Ca-permeable Kainate Receptor, Activation of NMDA receptors and postsynaptic events, Activation of kainate receptors upon glutamate binding, Assembly and cell surface presentation of NMDA receptors, Axon guidance, CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling, Developmental Biology, EGFR1, Fibroblast growth factor-1, Hippo signaling pathway - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Ionotropic activity of kainate receptors, L1CAM interactions, Long-term potentiation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of NMDA receptor-mediated neuronal transmission, Nervous system development, Neurexins and neuroligins, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, NrCAM interactions, Post NMDA receptor activation events, Protein-protein interactions at synapses, RAF/MAP kinase cascade, Ras activation upon Ca2+ influx through NMDA receptor, Signal Transduction, Synaptic adhesion-like molecules, Tight junction - Homo sapiens (human), Transmission across Chemical Synapses, Unblocking of NMDA receptors, glutamate binding and activation
UniProt: Q92796
Entrez ID: 1741
|
Does Knockout of UQCRC2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
UQCRC2
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: UQCRC2 (ubiquinol-cytochrome c reductase core protein 2)
Type: protein-coding
Summary: The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: aerobic respiration, cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, oxidative phosphorylation, proteolysis; MF: metal ion binding, metalloendopeptidase activity, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Complex III assembly, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Metabolism of proteins, Mitochondrial complex III assembly, Mitochondrial protein degradation, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: P22695
Entrez ID: 7385
|
Does Knockout of RUVBL2 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
RUVBL2
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: RUVBL2 (RuvB like AAA ATPase 2)
Type: protein-coding
Summary: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, box C/D snoRNP assembly, cellular response to UV, cellular response to estradiol stimulus, chromatin organization, chromatin remodeling, establishment of protein localization to chromatin, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, protein folding, protein stabilization, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of chromosome organization, regulation of double-strand break repair, regulation of embryonic development, regulation of transcription by RNA polymerase II, telomerase RNA localization to Cajal body, telomere maintenance; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATPase binding, DNA helicase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, TBP-class protein binding, TFIID-class transcription factor complex binding, beta-catenin binding, chromatin DNA binding, helicase activity, hydrolase activity, identical protein binding, nucleotide binding, promoter-enhancer loop anchoring activity, protein binding, protein homodimerization activity, transcription corepressor activity, unfolded protein binding; CC: Ino80 complex, MLL1 complex, NuA4 histone acetyltransferase complex, R2TP complex, RPAP3/R2TP/prefoldin-like complex, Swr1 complex, centrosome, ciliary basal body, cytoplasm, cytosol, dynein axonemal particle, euchromatin, extracellular exosome, membrane, nuclear matrix, nucleoplasm, nucleosome, nucleus, protein folding chaperone complex, ribonucleoprotein complex
Pathways: ATF-2 transcription factor network, C-MYC pathway, Cell Cycle, Chromatin modifying enzymes, Chromatin organization, Chromosome Maintenance, Extension of Telomeres, HATs acetylate histones, Integrin-linked kinase signaling, Regulation of nuclear beta catenin signaling and target gene transcription, Telomere Extension By Telomerase, Telomere Maintenance, Validated targets of C-MYC transcriptional activation
UniProt: Q9Y230
Entrez ID: 10856
|
Does Knockout of SNRPF in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
SNRPF
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SNRPF (small nuclear ribonucleoprotein polypeptide F)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in spliceosomal snRNP assembly. Located in cytosol and nucleus. Part of several cellular components, including methylosome; nucleus; and pICln-Sm protein complex. Biomarker of nasopharynx carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 7-methylguanosine cap hypermethylation, RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, protein-RNA complex assembly, spliceosomal snRNP assembly; MF: RNA binding, protein binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, pICln-Sm protein complex, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex
Pathways: Disease, Gene expression (Transcription), Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Homo sapiens (human), Viral Infection Pathways, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62306
Entrez ID: 6636
|
Does Knockout of KLRF2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
KLRF2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: KLRF2 (killer cell lectin like receptor F2)
Type: protein-coding
Summary: Enables protein homodimerization activity. Predicted to be involved in natural killer cell degranulation and positive regulation of cytokine production. Predicted to act upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: natural killer cell degranulation, positive regulation of cytokine production; MF: carbohydrate binding, protein binding, protein homodimerization activity; CC: membrane, plasma membrane
Pathways:
UniProt: D3W0D1
Entrez ID: 100431172
|
Does Knockout of ZNF230 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
ZNF230
|
response to virus
|
Hepatoma Cell Line
|
Gene: ZNF230 (zinc finger protein 230)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, metal ion binding, protein binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9UIE0
Entrez ID: 7773
|
Does Knockout of FHL1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
FHL1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: FHL1 (four and a half LIM domains 1)
Type: protein-coding
Summary: This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009].
Gene Ontology: BP: animal organ morphogenesis, cell differentiation, muscle organ development, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of cell growth, positive regulation of potassium ion transmembrane transport, regulation of atrial cardiac muscle cell membrane depolarization; MF: channel activator activity, metal ion binding, potassium channel activator activity, protein binding, transmembrane transporter binding, zinc ion binding; CC: cytoplasm, cytosol, focal adhesion, nucleus, plasma membrane
Pathways: JAK-STAT signaling pathway - Homo sapiens (human), Notch, Notch Signaling Pathway Netpath
UniProt: Q13642
Entrez ID: 2273
|
Does Knockout of P2RX2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
P2RX2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: P2RX2 (purinergic receptor P2X 2)
Type: protein-coding
Summary: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: behavioral response to pain, calcium ion transmembrane transport, chemical synaptic transmission, detection of hypoxic conditions in blood by carotid body chemoreceptor signaling, excitatory postsynaptic potential, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, neuromuscular junction development, neuromuscular synaptic transmission, peristalsis, positive regulation of calcium ion transport into cytosol, positive regulation of calcium-mediated signaling, purinergic nucleotide receptor signaling pathway, response to ATP, response to carbohydrate, response to hypoxia, response to ischemia, sensory perception of sound, sensory perception of taste, skeletal muscle fiber development, urinary bladder smooth muscle contraction; MF: ATP binding, extracellularly ATP-gated monoatomic cation channel activity, identical protein binding, ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, nucleotide binding, purinergic nucleotide receptor activity; CC: apical plasma membrane, membrane, neuronal cell body, neuronal dense core vesicle, plasma membrane, postsynapse, receptor complex, synapse
Pathways: Calcium signaling pathway - Homo sapiens (human), Elevation of cytosolic Ca2+ levels, Hemostasis, Neuroactive ligand-receptor interaction - Homo sapiens (human), Platelet calcium homeostasis, Platelet homeostasis, Purinergic signaling, Taste transduction - Homo sapiens (human)
UniProt: Q9UBL9
Entrez ID: 22953
|
Does Knockout of WDR18 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
WDR18
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: WDR18 (WD repeat domain 18)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated DNA replication, rRNA processing; CC: cytoplasm, dynein axonemal particle, nuclear pre-replicative complex, nucleolus, nucleoplasm, nucleus, rixosome complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9BV38
Entrez ID: 57418
|
Does Knockout of RHOU in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
RHOU
|
cell proliferation
|
Cancer Cell Line
|
Gene: RHOU (ras homolog family member U)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, Rac protein signal transduction, actin cytoskeleton organization, actin filament organization, cytoskeleton organization, endocytosis, establishment of cell polarity, positive regulation of focal adhesion disassembly, positive regulation of protein targeting to mitochondrion, regulation of cell shape, regulation of small GTPase mediated signal transduction, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, guanyl-nucleotide exchange factor activity, metal ion binding, nucleotide binding, protein binding, protein kinase binding, protein-macromolecule adaptor activity; CC: Golgi apparatus, Golgi membrane, anchoring junction, cell projection, cytosol, endosome membrane, focal adhesion, membrane, plasma membrane, podosome
Pathways: Cytokine Signaling in Immune system, Immune System, Interleukin-4 and Interleukin-13 signaling, RHO GTPase cycle, RHOU GTPase cycle, Signal Transduction, Signaling by Interleukins, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q7L0Q8
Entrez ID: 58480
|
Does Knockout of RPL35 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
RPL35
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RPL35 (ribosomal protein L35)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation; MF: RNA binding, mRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, membrane, nucleolus, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P42766
Entrez ID: 11224
|
Does Knockout of IFT22 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
IFT22
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: IFT22 (intraflagellar transport 22)
Type: protein-coding
Summary: Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to be located in ciliary tip. Predicted to be part of intraciliary transport particle B. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cilium assembly, intracellular protein transport, intraciliary anterograde transport; MF: GTP binding, GTPase activity, nucleotide binding; CC: cell projection, centrosome, ciliary tip, cilium, endomembrane system, intraciliary transport particle B
Pathways: Ciliary landscape, Cilium Assembly, Intraflagellar transport, Intraflagellar transport proteins binding to dynein, Organelle biogenesis and maintenance
UniProt: Q9H7X7
Entrez ID: 64792
|
Does Knockout of MCM7 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
MCM7
|
cell proliferation
|
Cancer Cell Line
|
Gene: MCM7 (minichromosome maintenance complex component 7)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA replication, DNA replication initiation, DNA strand elongation involved in DNA replication, cell population proliferation, cellular response to epidermal growth factor stimulus, cellular response to xenobiotic stimulus, double-strand break repair via break-induced replication, regulation of DNA-templated DNA replication initiation, regulation of phosphorylation, response to xenobiotic stimulus; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: CMG complex, MCM complex, chromatin, chromosome, chromosome, telomeric region, membrane, nucleolus, nucleoplasm, nucleus
Pathways: ATR signaling pathway, Cell cycle, Cell cycle - Homo sapiens (human), Ciliary landscape, DNA Replication, DNA replication - Homo sapiens (human), G1 to S cell cycle control, Retinoblastoma gene in cancer, TNFalpha, cdk regulation of dna replication, miRNA regulation of DNA damage response
UniProt: P33993
Entrez ID: 4176
|
Does Knockout of INHA in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
INHA
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: INHA (inhibin subunit alpha)
Type: protein-coding
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: cell differentiation, cell surface receptor protein serine/threonine kinase signaling pathway, cell surface receptor signaling pathway, cell-cell signaling, erythrocyte differentiation, hemoglobin biosynthetic process, male gonad development, negative regulation of B cell differentiation, negative regulation of cell cycle, negative regulation of follicle-stimulating hormone secretion, negative regulation of macrophage differentiation, negative regulation of multicellular organismal process, negative regulation of phosphorylation, negative regulation of type II interferon production, ovarian follicle development, positive regulation of follicle-stimulating hormone secretion, regulation of cell cycle, regulation of cell population proliferation, regulation of follicle-stimulating hormone secretion, signal transduction, skeletal system development, system development; MF: cytokine activity, growth factor activity, hormone activity, inhibin binding, protein binding, protein-containing complex binding, signaling receptor binding; CC: extracellular region, extracellular space, inhibin A complex, inhibin B complex, inhibin-betaglycan-ActRII complex, neuronal cell body, photoreceptor inner segment, photoreceptor outer segment
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human), Glycoprotein hormones, Metabolism of proteins, Ovarian infertility, Peptide hormone biosynthesis, Peptide hormone metabolism, Signal Transduction, Signaling by Activin, Signaling by BMP, Signaling by TGFB family members, Signaling by TGFBR3, TGFBR3 regulates activin signaling
UniProt: P05111
Entrez ID: 3623
|
Does Knockout of DGCR8 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
DGCR8
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: DGCR8 (DGCR8 microprocessor complex subunit)
Type: protein-coding
Summary: This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: DNA damage response, positive regulation of pre-miRNA processing, primary miRNA processing, regulation of stem cell proliferation; MF: RNA binding, double-stranded RNA binding, heme binding, identical protein binding, metal ion binding, primary miRNA binding, protein binding, protein homodimerization activity, protein-RNA adaptor activity, protein-macromolecule adaptor activity; CC: cytoplasm, cytosol, glutamatergic synapse, microprocessor complex, nuclear body, nucleolus, nucleoplasm, nucleus, postsynaptic density, site of double-strand break
Pathways: 22q11.2 copy number variation syndrome, DDX1 as a regulatory component of the Drosha microprocessor, Direct p53 effectors, Gene Silencing by RNA, Gene expression (Transcription), Generic Transcription Pathway, MicroRNA (miRNA) biogenesis, RNA Polymerase II Transcription, Transcriptional Regulation by MECP2, exRNA mechanism of action and biogenesis, miRNA Biogenesis
UniProt: Q8WYQ5
Entrez ID: 54487
|
Does Knockout of NUDT21 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
NUDT21
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: NUDT21 (nudix hydrolase 21)
Type: protein-coding
Summary: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA alternative polyadenylation, mRNA processing, positive regulation of pro-B cell differentiation, positive regulation of stem cell differentiation, post-transcriptional regulation of gene expression, protein heterotetramerization, protein tetramerization; MF: RNA binding, chromatin binding, histone deacetylase binding, identical protein binding, mRNA 3'-UTR AU-rich region binding, mRNA binding, protein binding, protein homodimerization activity; CC: centriolar satellite, centrosome, cytoplasm, mRNA cleavage and polyadenylation specificity factor complex, mRNA cleavage factor complex, nuclear body, nucleoplasm, nucleus, paraspeckles
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human)
UniProt: O43809
Entrez ID: 11051
|
Does Knockout of ZMYND8 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
ZMYND8
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: ZMYND8 (zinc finger MYND-type containing 8)
Type: protein-coding
Summary: The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin organization, double-strand break repair via homologous recombination, modulation of excitatory postsynaptic potential, negative regulation of DNA-templated transcription, negative regulation of cell migration, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of dendritic spine development, positive regulation of dendritic spine maintenance, positive regulation of filopodium assembly, positive regulation of transcription elongation by RNA polymerase II, protein localization to chromatin, regulation of DNA-templated transcription, regulation of postsynaptic density protein 95 clustering; MF: DNA-binding transcription factor binding, histone H3K14ac reader activity, histone H3K4me1 reader activity, metal ion binding, protein binding, protein domain specific binding, transcription corepressor activity, zinc ion binding; CC: chromatin, chromosome, cytoplasm, dendritic shaft, dendritic spine, nucleolus, nucleoplasm, nucleus, site of DNA damage
Pathways:
UniProt: Q9ULU4
Entrez ID: 23613
|
Does Knockout of BAP1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
BAP1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: BAP1 (BRCA1 associated deubiquitinase 1)
Type: protein-coding
Summary: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013].
Gene Ontology: BP: cell differentiation, cell population proliferation, chromatin organization, common myeloid progenitor cell proliferation, erythrocyte differentiation, erythrocyte maturation, gene expression, granulocyte differentiation, hematopoietic stem cell homeostasis, heterochromatin formation, in utero embryonic development, leukocyte proliferation, macrophage homeostasis, mitotic cell cycle, monoubiquitinated protein deubiquitination, myeloid cell apoptotic process, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, neuron cellular homeostasis, neutrophil differentiation, nucleate erythrocyte differentiation, platelet morphogenesis, positive regulation of protein targeting to mitochondrion, protein K48-linked deubiquitination, protein deubiquitination, protein modification process, proteolysis, regulation of cell cycle, regulation of cell growth, regulation of cytokine production involved in inflammatory response, regulation of gene expression, regulation of inflammatory response, thrombocyte differentiation, tissue homeostasis, ubiquitin-dependent protein catabolic process; MF: chromatin DNA binding, chromatin binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2A deubiquitinase activity, hydrolase activity, peptidase activity, protein binding; CC: PR-DUB complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, Metabolism of proteins, Pathways in clear cell renal cell carcinoma, Post-translational protein modification, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, UCH proteinases
UniProt: Q92560
Entrez ID: 8314
|
Does Knockout of PSMC5 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
PSMC5
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: PSMC5 (proteasome 26S subunit, ATPase 5)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of programmed cell death, positive regulation of DNA-templated transcription, positive regulation of inclusion body assembly, positive regulation of proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of transcription by RNA polymerase II; MF: ATP binding, ATP hydrolysis activity, DNA-binding transcription factor binding, TBP-class protein binding, general transcription initiation factor binding, nucleotide binding, proteasome-activating activity, protein binding, signaling receptor binding, thyrotropin-releasing hormone receptor binding, transcription factor binding; CC: blood microparticle, cytoplasm, cytoplasmic vesicle, cytosol, cytosolic proteasome complex, extracellular exosome, inclusion body, membrane, nuclear proteasome complex, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, base subcomplex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Nuclear Receptors Meta-Pathway, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Pregnane X receptor pathway, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P62195
Entrez ID: 5705
|
Does Knockout of KCNIP2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
KCNIP2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: KCNIP2 (potassium voltage-gated channel interacting protein 2)
Type: protein-coding
Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: action potential, chemical synaptic transmission, clustering of voltage-gated potassium channels, detection of calcium ion, membrane repolarization, membrane repolarization during cardiac muscle cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, muscle contraction, positive regulation of potassium ion export across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of heart contraction, regulation of membrane repolarization, regulation of potassium ion export across plasma membrane, regulation of potassium ion transmembrane transport, regulation of signal transduction, signal transduction; MF: A-type (transient outward) potassium channel activity, ER retention sequence binding, calcium ion binding, identical protein binding, metal ion binding, potassium channel activity, potassium channel regulator activity, protein binding, protein-containing complex binding, transmembrane transporter binding; CC: Kv4.2-KChIP2 channel complex, cytoplasm, dendrite, membrane, monoatomic ion channel complex, plasma membrane, synapse, voltage-gated potassium channel complex
Pathways: 3-Methylthiofentanyl Action Pathway, Acebutolol Action Pathway, Alfentanil Action Pathway, Alprenolol Action Pathway, Alvimopan Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Anileridine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Benzocaine Action Pathway, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupivacaine Action Pathway, Bupranolol Action Pathway, Buprenorphine Action Pathway, Cardiac conduction, Carfentanil Action Pathway, Carteolol Action Pathway, Carvedilol Action Pathway, Chloroprocaine Action Pathway, Citalopram Action Pathway, Cocaine Action Pathway, Codeine Action Pathway, Desipramine Action Pathway, Dezocine Action Pathway, Dibucaine Action Pathway, Dihydromorphine Action Pathway, Diltiazem Action Pathway, Dimethylthiambutene Action Pathway, Diphenoxylate Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Epinephrine Action Pathway, Escitalopram Action Pathway, Esmolol Action Pathway, Ethylmorphine Action Pathway, Felodipine Action Pathway, Fentanyl Action Pathway, Flecainide Action Pathway, Fluoxetine Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, Heroin Action Pathway, Hydrocodone Action Pathway, Hydromorphone Action Pathway, Ibutilide Action Pathway, Imipramine Action Pathway, Isoprenaline Action Pathway, Isradipine Action Pathway, Ketobemidone Action Pathway, Labetalol Action Pathway, Levallorphan Action Pathway, Levobunolol Action Pathway, Levobupivacaine Action Pathway, Levomethadyl Acetate Action Action Pathway, Levorphanol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, Lidocaine (Local Anaesthetic) Action Pathway, Mepivacaine Action Pathway, Methadone Action Pathway, Methadyl Acetate Action Pathway, Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Morphine Action Pathway, Muscle contraction, Muscle/Heart Contraction, Nadolol Action Pathway, Nalbuphine Action Pathway, Naloxone Action Pathway, Naltrexone Action Pathway, Nebivolol Action Pathway, Nicotine Action Pathway, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Oxybuprocaine Action Pathway, Oxycodone Action Pathway, Oxymorphone Action Pathway, Penbutolol Action Pathway, Pentazocine Action Pathway, Phase 1 - inactivation of fast Na+ channels, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Practolol Action Pathway, Prilocaine Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Procaine Action Pathway, Proparacaine Action Pathway, Propoxyphene Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Remifentanil Action Pathway, Ropivacaine Action Pathway, Sotalol Action Pathway, Sufentanil Action Pathway, Timolol Action Pathway, Tocainide Action Pathway, Tramadol Action Action Pathway, Verapamil Action Pathway
UniProt: Q9NS61
Entrez ID: 30819
|
Does Knockout of SDHD in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
SDHD
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SDHD (succinate dehydrogenase complex subunit D)
Type: protein-coding
Summary: This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: cellular response to hypoxia, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, regulation of catecholamine secretion, tricarboxylic acid cycle; MF: electron transfer activity, heme binding, metal ion binding, protein binding, succinate dehydrogenase (quinone) activity, ubiquinone binding; CC: membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion, respiratory chain complex II (succinate dehydrogenase)
Pathways: 2-ketoglutarate dehydrogenase complex deficiency, Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Citrate cycle (TCA cycle) - Homo sapiens (human), Citric Acid Cycle, Citric acid cycle (TCA cycle), Congenital lactic acidosis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Fumarase deficiency, Glutaminolysis and Cancer, Huntington disease - Homo sapiens (human), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial CII Assembly, Mitochondrial Electron Transport Chain, Mitochondrial complex II deficiency, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Pyruvate dehydrogenase deficiency (E2), Pyruvate dehydrogenase deficiency (E3), Respiratory electron transport, TCA Cycle (aka Krebs or citric acid cycle), TCA cycle, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate, Thermogenesis - Homo sapiens (human), Warburg Effect, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: O14521
Entrez ID: 6392
|
Does Knockout of RACGAP1 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
RACGAP1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: RACGAP1 (Rac GTPase activating protein 1)
Type: protein-coding
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: Rho protein signal transduction, actomyosin contractile ring assembly, cell differentiation, cell division, erythrocyte differentiation, mitotic cytokinesis, mitotic spindle midzone assembly, monoatomic ion transport, neuroblast proliferation, positive regulation of cytokinesis, regulation of attachment of spindle microtubules to kinetochore, regulation of embryonic development, regulation of small GTPase mediated signal transduction, signal transduction, spermatogenesis, sulfate transmembrane transport; MF: GTPase activator activity, alpha-tubulin binding, beta-tubulin binding, gamma-tubulin binding, lipid binding, metal ion binding, microtubule binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding, protein kinase binding, protein-macromolecule adaptor activity, zinc ion binding; CC: Flemming body, acrosomal vesicle, centralspindlin complex, cleavage furrow, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, cytosol, extracellular exosome, membrane, microtubule, midbody, mitochondrion, mitotic spindle, nucleoplasm, nucleus, plasma membrane, spindle, spindle midzone
Pathways: Adaptive Immune System, Aurora B signaling, CDC42 GTPase cycle, COPI-dependent Golgi-to-ER retrograde traffic, EGFR1, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, RAC1 GTPase cycle, RAC1 signaling pathway, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, Regulation of CDC42 activity, Regulation of RAC1 activity, Signal Transduction, Signal Transduction of S1P Receptor, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport, Wnt signaling pathway and pluripotency
UniProt: Q9H0H5
Entrez ID: 29127
|
Does Knockout of PDZD2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
PDZD2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PDZD2 (PDZ domain containing 2)
Type: protein-coding
Summary: The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015].
Gene Ontology: CC: cell-cell junction, centriolar satellite, cytoplasm, cytosol, endoplasmic reticulum, extracellular region, nucleus, plasma membrane
Pathways:
UniProt: O15018
Entrez ID: 23037
|
Does Knockout of HAUS1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
HAUS1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: HAUS1 (HAUS augmin like complex subunit 1)
Type: protein-coding
Summary: HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010].
Gene Ontology: BP: cell division, centrosome cycle, regulation of microtubule nucleation, spindle assembly; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule, mitotic spindle microtubule, spindle, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q96CS2
Entrez ID: 115106
|
Does Knockout of COPS8 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
COPS8
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: COPS8 (COP9 signalosome subunit 8)
Type: protein-coding
Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: COP9 signalosome assembly, activation of NF-kappaB-inducing kinase activity, negative regulation of cell population proliferation, protein deneddylation, protein neddylation, protein phosphorylation, regulation of protein neddylation; CC: COP9 signalosome, cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Cargo recognition for clathrin-mediated endocytosis, Ciliary landscape, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q99627
Entrez ID: 10920
|
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