prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of RRS1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | RRS1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: RRS1 (regulator of ribosome synthesis 1)
Type: protein-coding
Summary: Enables 5S rRNA binding activity. Involved in several processes, including mitotic metaphase plate congression; protein localization to nucleolus; and ribosomal large subunit assembly. Located in condensed nuclear chromosome; n... |
Does Knockout of BET1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | BET1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: BET1 (Bet1 golgi vesicular membrane trafficking protein)
Type: protein-coding
Summary: This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide... |
Does Knockout of CCDC112 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,631 | Knockout | CCDC112 | response to chemicals | Non-Small Cell Lung Adenocarcinoma Cell Line | Gene: CCDC112 (coiled-coil domain containing 112)
Type: protein-coding
Summary: Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: centriolar satellite, cytoplasm, cytoskeleton
Pathways:
UniProt: Q8NEF3
Entrez ID: ... |
Does Knockout of DNMT1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | DNMT1 | cell proliferation | Glioblastoma Cell Line | Gene: DNMT1 (DNA methyltransferase 1)
Type: protein-coding
Summary: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi... |
Does Knockout of BICDL2 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | BICDL2 | cell proliferation | T-lymphoma cell line | Gene: BICDL2 (BICD family like cargo adaptor 2)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and vesicle transport along microtubule. Predicted to be located in cytoplasm. [provided by Alliance of Genome... |
Does Knockout of CRCP in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | CRCP | cell proliferation | Mammary Gland Tumor Cell Line | Gene: CRCP (CGRP receptor component)
Type: protein-coding
Summary: This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been charac... |
Does Knockout of RABEP2 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | RABEP2 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: RABEP2 (rabaptin, RAB GTPase binding effector protein 2)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity and growth factor activity. Involved in regulation of cilium assembly. Located in cytosol; intracellular membrane-bounded organelle; and microtubule organizing cente... |
Does Knockout of ATF4 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | ATF4 | cell proliferation | T-lymphoma cell line | Gene: ATF4 (activating transcription factor 4)
Type: protein-coding
Summary: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also is... |
Does Knockout of PALM3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | PALM3 | cell proliferation | Endometrial Cancer Cell Line | Gene: PALM3 (paralemmin 3)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Involved in Toll signaling pathway; negative regulation of cytokine-mediated signaling pathway; and response to lipopolysaccharide. Predicted to be located in cytoplasm and plasma membrane. [provided by Al... |
Does Knockout of HSPA13 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | HSPA13 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: HSPA13 (heat shock protein family A (Hsp70) member 13)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory pro... |
Does Knockout of SIAH3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | SIAH3 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: SIAH3 (siah E3 ubiquitin protein ligase family member 3)
Type: protein-coding
Summary: Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in negative regulation of protein targeting to mitochondrion and regulation of protein stability.... |
Does Knockout of LAS1L in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | LAS1L | cell proliferation | Multiple Myeloma Cell Line | Gene: LAS1L (LAS1 like ribosome biogenesis factor)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in membrane. Part of MLL1 complex. Implicated in Wilson-Turner syndrome. [provided by Alliance of Genome ... |
Does Knockout of SMIM14 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | SMIM14 | cell proliferation | Medulloblastoma Cell Line | Gene: SMIM14 (small integral membrane protein 14)
Type: protein-coding
Summary: Predicted to act upstream of or within blastocyst hatching. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: endoplasmic reticulum, endoplasmic reticulum memb... |
Does Knockout of CCDC124 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | CCDC124 | response to chemicals | Glioblastoma Cell Line | Gene: CCDC124 (coiled-coil domain containing 124)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in cell division. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, positive regula... |
Does Knockout of RFFL in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | RFFL | cell proliferation | Medulloblastoma Cell Line | Gene: RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase)
Type: protein-coding
Summary: Enables enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in cellular protein metabolic process; negative regulation of cysteine-type endopeptid... |
Does Knockout of ADIG in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | ADIG | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: ADIG (adipogenin)
Type: protein-coding
Summary: ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 [PubMed 15567149]; Hong et al., 2005 [PubMed 16132694]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: brown fat cell differentiat... |
Does Knockout of MAB21L2 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | MAB21L2 | cell proliferation | Ovarian Cancer Cell Line | Gene: MAB21L2 (mab-21 like 2)
Type: protein-coding
Summary: This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein encoded by this gene is ... |
Does Knockout of TCTN3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | TCTN3 | cell proliferation | Endometrial Cancer Cell Line | Gene: TCTN3 (tectonic family member 3)
Type: protein-coding
Summary: This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom... |
Does Knockout of RIOK2 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | RIOK2 | cell proliferation | Gastric Cancer Cell Line | Gene: RIOK2 (RIO kinase 2)
Type: protein-coding
Summary: Predicted to enable protein kinase activity. Involved in several processes, including positive regulation of rRNA processing; positive regulation of ribosomal small subunit export from nucleus; and regulation of mitotic metaphase/anaphase transiti... |
Does Knockout of CHL1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | CHL1 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: CHL1 (cell adhesion molecule L1 like)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene ... |
Does Knockout of NUB1 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | NUB1 | response to chemicals | Monocytic Leukemia Cell Line | Gene: NUB1 (negative regulator of ubiquitin like proteins 1)
Type: protein-coding
Summary: This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by... |
Does Knockout of PAMR1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | PAMR1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: PAMR1 (peptidase domain containing associated with muscle regeneration 1)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Al... |
Does Knockout of PLAU in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | PLAU | cell proliferation | Gastric Cancer Cell Line | Gene: PLAU (plasminogen activator, urokinase)
Type: protein-coding
Summary: This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond... |
Does Knockout of STT3B in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | STT3B | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: STT3B (STT3 oligosaccharyltransferase complex catalytic subunit B)
Type: protein-coding
Summary: The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosy... |
Does Knockout of FAM227A in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | FAM227A | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: FAM227A (family with sequence similarity 227 member A)
Type: protein-coding
Summary: family with sequence similarity 227 member A
Gene Ontology:
Pathways:
UniProt: F5H4B4
Entrez ID: 646851 |
Does Knockout of PCGF6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | PCGF6 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: PCGF6 (polycomb group ring finger 6)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcr... |
Does Knockout of ARPC4 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | ARPC4 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: ARPC4 (actin related protein 2/3 complex subunit 4)
Type: protein-coding
Summary: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subun... |
Does Knockout of RTCB in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | RTCB | cell proliferation | Medulloblastoma Cell Line | Gene: RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Type: protein-coding
Summary: Enables RNA ligase (ATP) activity and vinculin binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Located in cytosol and nucleoplasm. Part of tRNA-splicing ligase complex. [provide... |
Does Knockout of IL5RA in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | IL5RA | response to virus | Huh-7 Cell | Gene: IL5RA (interleukin 5 receptor subunit alpha)
Type: protein-coding
Summary: The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the re... |
Does Knockout of WBP1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | WBP1 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: WBP1 (WW domain binding protein 1)
Type: protein-coding
Summary: The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encod... |
Does Knockout of RNPC3 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | RNPC3 | cell proliferation | Medulloblastoma Cell Line | Gene: RNPC3 (RNA binding region (RNP1, RRM) containing 3)
Type: protein-coding
Summary: Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type sp... |
Does Knockout of BCL9L in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | BCL9L | response to virus | Hepatoma Cell Line | Gene: BCL9L (BCL9 like)
Type: protein-coding
Summary: Enables beta-catenin binding activity. Involved in several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; and positive regulation of... |
Does Knockout of MFAP1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | MFAP1 | cell proliferation | Endometrial Cancer Cell Line | Gene: MFAP1 (microfibril associated protein 1)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in centrosome; microfibril; and nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of NOX1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | NOX1 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: NOX1 (NADPH oxidase 1)
Type: protein-coding
Summary: This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms hav... |
Does Knockout of NHLRC2 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | NHLRC2 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: NHLRC2 (NHL repeat containing 2)
Type: protein-coding
Summary: Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, cytosol, extracellular region, platelet alpha granule lumen
Pathways:
UniProt: Q8NBF2
Entrez ID:... |
Does Knockout of MYC in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | MYC | cell proliferation | Gastric Cancer Cell Line | Gene: MYC (MYC proto-oncogene, bHLH transcription factor)
Type: protein-coding
Summary: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcri... |
Does Knockout of GTF2B in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | GTF2B | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: GTF2B (general transcription factor IIB)
Type: protein-coding
Summary: This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) w... |
Does Knockout of TRMT10C in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | TRMT10C | cell proliferation | Colonic Cancer Cell Line | Gene: TRMT10C (tRNA methyltransferase 10C, mitochondrial RNase P subunit)
Type: protein-coding
Summary: This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mito... |
Does Knockout of C8orf48 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | C8orf48 | cell proliferation | Cancer Cell Line | Gene: C8orf48 (chromosome 8 open reading frame 48)
Type: protein-coding
Summary: chromosome 8 open reading frame 48
Gene Ontology:
Pathways:
UniProt: Q96LL4
Entrez ID: 157773 |
Does Knockout of MOB4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | MOB4 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: MOB4 (MOB family member 4, phocein)
Type: protein-coding
Summary: This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic g... |
Does Knockout of RBX1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | RBX1 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: RBX1 (ring-box 1)
Type: protein-coding
Summary: This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnove... |
Does Knockout of CCNB1 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | CCNB1 | cell proliferation | Melanoma Cell Line | Gene: CCNB1 (cyclin B1)
Type: protein-coding
Summary: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of... |
Does Knockout of MYC in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | MYC | cell proliferation | Medulloblastoma Cell Line | Gene: MYC (MYC proto-oncogene, bHLH transcription factor)
Type: protein-coding
Summary: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcri... |
Does Knockout of KRTAP9-6 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | KRTAP9-6 | cell proliferation | Neuroblastoma Cell Line | Gene: KRTAP9-6 (keratin associated protein 9-6)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
... |
Does Knockout of GTF3C5 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | GTF3C5 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: GTF3C5 (general transcription factor IIIC subunit 5)
Type: protein-coding
Summary: Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and tRNA transcription by RNA polymerase III. Predicted to act upstream of or within ske... |
Does Knockout of GRIN1 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | GRIN1 | cell proliferation | Multiple Myeloma Cell Line | Gene: GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)
Type: protein-coding
Summary: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arr... |
Does Knockout of EED in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | EED | response to virus | Cervical Adenocarcinoma Cell Line | Gene: EED (embryonic ectoderm development)
Type: protein-coding
Summary: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. ... |
Does Knockout of SP7 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | SP7 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SP7 (Sp7 transcription factor)
Type: protein-coding
Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc fin... |
Does Knockout of NACAD in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | NACAD | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: NACAD (NAC alpha domain containing)
Type: protein-coding
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be ac... |
Does Knockout of TSHZ3 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | TSHZ3 | cell proliferation | Glioblastoma Cell Line | Gene: TSHZ3 (teashirt zinc finger homeobox 3)
Type: protein-coding
Summary: This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gen... |
Does Knockout of TAF6L in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | TAF6L | cell proliferation | Astrocytoma Cell Line | Gene: TAF6L (TATA-box binding protein associated factor 6 like)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core ... |
Does Knockout of CYB5R2 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | CYB5R2 | response to virus | Lung Cancer Cell Line | Gene: CYB5R2 (cytochrome b5 reductase 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, ... |
Does Knockout of SNX3 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,430 | Knockout | SNX3 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: SNX3 (sorting nexin 3)
Type: protein-coding
Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil reg... |
Does Knockout of GAPVD1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | GAPVD1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: GAPVD1 (GTPase activating protein and VPS9 domains 1)
Type: protein-coding
Summary: Enables GTPase activating protein binding activity and guanyl-nucleotide exchange factor activity. Involved in regulation of protein transport. Located in cytosol and plasma membrane. [provided by Alliance of Genom... |
Does Knockout of HS6ST1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | HS6ST1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: HS6ST1 (heparan sulfate 6-O-sulfotransferase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures t... |
Does Knockout of LCMT1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | LCMT1 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: LCMT1 (leucine carboxyl methyltransferase 1)
Type: protein-coding
Summary: LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by... |
Does Knockout of GIMAP5 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | GIMAP5 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: GIMAP5 (GTPase, IMAP family member 5)
Type: protein-coding
Summary: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. Th... |
Does Knockout of B3GALNT1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | B3GALNT1 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: B3GALNT1 (beta-1,3-N-acetylgalactosaminyltransferase 1 (Globoside blood group))
Type: protein-coding
Summary: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using differe... |
Does Knockout of ESPL1 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | ESPL1 | cell proliferation | Astrocytoma Cell Line | Gene: ESPL1 (extra spindle pole bodies like 1, separase)
Type: protein-coding
Summary: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via disti... |
Does Knockout of MYB in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | MYB | response to virus | Lung Cancer Cell Line | Gene: MYB (MYB proto-oncogene, transcription factor)
Type: protein-coding
Summary: This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or... |
Does Knockout of PFN1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | PFN1 | cell proliferation | Medulloblastoma Cell Line | Gene: PFN1 (profilin 1)
Type: protein-coding
Summary: This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associa... |
Does Knockout of NRAP in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | NRAP | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: NRAP (nebulin related anchoring protein)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity and muscle alpha-actinin binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to be located in fascia adherens; muscle tendon junctio... |
Does Knockout of S1PR2 in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | S1PR2 | cell proliferation | Prostate Cancer Cell Line | Gene: S1PR2 (sphingosine-1-phosphate receptor 2)
Type: protein-coding
Summary: This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and tran... |
Does Knockout of NUP98 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | NUP98 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: NUP98 (nucleoporin 98 and 96 precursor)
Type: protein-coding
Summary: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nu... |
Does Activation of TPST1 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | TPST1 | response to virus | Hepatoma Cell Line | Gene: TPST1 (tyrosylprotein sulfotransferase 1)
Type: protein-coding
Summary: Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation. Is integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of EIF2B4 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | EIF2B4 | cell proliferation | Gastric Cancer Cell Line | Gene: EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)
Type: protein-coding
Summary: Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta... |
Does Knockout of SPEF2 in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | SPEF2 | cell proliferation | Bladder Carcinoma | Gene: SPEF2 (sperm flagellar 2)
Type: protein-coding
Summary: Involved in sperm axoneme assembly. Located in sperm flagellum. Implicated in spermatogenic failure 43. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: brain morphogenesis, cell differentiation, epithelial cil... |
Does Knockout of UBAP2L in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | UBAP2L | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: UBAP2L (ubiquitin associated protein 2 like)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in binding activity of sperm to zona pellucida and stress granule assembly. Acts upstream of or within hematopoietic stem cell homeostasis. Part of PcG protein complex. [provided by Al... |
Does Knockout of PPFIA4 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | PPFIA4 | cell proliferation | Glioblastoma Cell Line | Gene: PPFIA4 (PPFI scaffold protein A4)
Type: protein-coding
Summary: PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family. See liprin-alpha-1 (LIP1, or PPFIA1; MIM 611054) for background on liprins.[supplied by OMIM, Mar 2008].
Gene Ontology: CC: cell surface, cytoplasm, cytosol,... |
Does Knockout of GMDS in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | GMDS | cell proliferation | Colonic Cancer Cell Line | Gene: GMDS (GDP-mannose 4,6-dehydratase)
Type: protein-coding
Summary: GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third step... |
Does Activation of ARMC5 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | ARMC5 | response to virus | Hepatoma Cell Line | Gene: ARMC5 (armadillo repeat containing 5)
Type: protein-coding
Summary: This gene encodes a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. The ARM repeat is a tandemly repeated sequence motif with approximately 40 amino acid long. This repeat is implicated in mediating protein-pro... |
Does Knockout of STAG1 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | STAG1 | cell proliferation | Neuroblastoma Cell Line | Gene: STAG1 (STAG1 cohesin complex component)
Type: protein-coding
Summary: This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replic... |
Does Knockout of PNO1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | PNO1 | cell proliferation | Colonic Cancer Cell Line | Gene: PNO1 (partner of NOB1 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, nucleic acid binding, protein binding; CC: cytosol, nucleolus, nucleoplasm,... |
Does Knockout of DGUOK in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | DGUOK | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: DGUOK (deoxyguanosine kinase)
Type: protein-coding
Summary: In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene ... |
Does Knockout of CCDC86 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | CCDC86 | cell proliferation | Breast Cancer Cell Line | Gene: CCDC86 (coiled-coil domain containing 86)
Type: protein-coding
Summary: Enables RNA binding activity. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromosome segregation, mitotic nuclear division; MF: RNA bindin... |
Does Knockout of INS-IGF2 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | INS-IGF2 | cell proliferation | Hepatoma Cell Line | Gene: INS-IGF2 (INS-IGF2 readthrough)
Type: protein-coding
Summary: This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-termin... |
Does Knockout of CA10 in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | CA10 | cell proliferation | Bladder Carcinoma | Gene: CA10 (carbonic anhydrase 10)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic ... |
Does Knockout of RPL35 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | RPL35 | cell proliferation | Colonic Cancer Cell Line | Gene: RPL35 (ribosomal protein L35)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of TAAR2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | TAAR2 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: TAAR2 (trace amine associated receptor 2)
Type: protein-coding
Summary: Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided... |
Does Knockout of TMEM62 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | TMEM62 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: TMEM62 (transmembrane protein 62)
Type: protein-coding
Summary: Predicted to enable hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: hydrolase activity, protein binding
Pathways:
... |
Does Knockout of CA5B in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | CA5B | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: CA5B (carbonic anhydrase 5B)
Type: protein-coding
Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, b... |
Does Knockout of GOLGA6L6 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | GOLGA6L6 | cell proliferation | Medulloblastoma Cell Line | Gene: GOLGA6L6 (golgin A6 family like 6 (gene/pseudogene))
Type: protein-coding
Summary: golgin A6 family like 6 (gene/pseudogene)
Gene Ontology:
Pathways:
UniProt: A8MZA4
Entrez ID: 727832 |
Does Knockout of LRRN1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | LRRN1 | cell proliferation | Ovarian Cancer Cell Line | Gene: LRRN1 (leucine rich repeat neuronal 1)
Type: protein-coding
Summary: Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Geno... |
Does Knockout of MC3R in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | MC3R | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: MC3R (melanocortin 3 receptor)
Type: protein-coding
Summary: This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus ... |
Does Knockout of METTL3 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | METTL3 | cell proliferation | Neuroblastoma Cell Line | Gene: METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)
Type: protein-coding
Summary: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine re... |
Does Knockout of APLP2 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | APLP2 | cell proliferation | Multiple Myeloma Cell Line | Gene: APLP2 (amyloid beta precursor like protein 2)
Type: protein-coding
Summary: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, cop... |
Does Knockout of THG1L in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | THG1L | cell proliferation | Medulloblastoma Cell Line | Gene: THG1L (tRNA-histidine guanylyltransferase 1 like)
Type: protein-coding
Summary: The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which... |
Does Knockout of RELA in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | RELA | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: RELA (RELA proto-oncogene, NF-kB subunit)
Type: protein-coding
Summary: NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucl... |
Does Knockout of MYH9 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | MYH9 | cell proliferation | Monocytic Leukemia Cell Line | Gene: MYH9 (myosin heavy chain 9)
Type: protein-coding
Summary: This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-l... |
Does Knockout of DDX42 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | DDX42 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: DDX42 (DEAD-box helicase 42)
Type: protein-coding
Summary: This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure su... |
Does Knockout of INHBA in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | INHBA | cell proliferation | Endometrial Cancer Cell Line | Gene: INHBA (inhibin subunit beta A)
Type: protein-coding
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. Thes... |
Does Knockout of MIR4442 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | MIR4442 | response to chemicals | Monocytic Leukemia Cell Line | Gene: MIR4442 (microRNA 4442)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of RBBP5 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | RBBP5 | cell proliferation | Colonic Cancer Cell Line | Gene: RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit)
Type: protein-coding
Summary: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein,... |
Does Knockout of LSM5 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | LSM5 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: LSM5 (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which c... |
Does Knockout of PHF1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | PHF1 | cell proliferation | Melanoma Cell Line | Gene: PHF1 (PHD finger protein 1)
Type: protein-coding
Summary: This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to dou... |
Does Knockout of ETFRF1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | ETFRF1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: ETFRF1 (electron transfer flavoprotein regulatory factor 1)
Type: protein-coding
Summary: Involved in respiratory electron transport chain. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of cellular respiration, negati... |
Does Knockout of MOBP in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | MOBP | response to chemicals | Glioblastoma Cell Line | Gene: MOBP (myelin associated oligodendrocyte basic protein)
Type: protein-coding
Summary: Predicted to enable actin binding activity and myosin binding activity. Predicted to be a structural constituent of myelin sheath. Predicted to be involved in nervous system development. Predicted to be located in... |
Does Knockout of PPAT in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | PPAT | cell proliferation | acute lymphoblastic leukemia cell line | Gene: PPAT (phosphoribosyl pyrophosphate amidotransferase)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pat... |
Does Knockout of RRN3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | RRN3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: RRN3 (RNA polymerase I transcription factor RRN3)
Type: protein-coding
Summary: Enables RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation from RNA polymerase I promoter. Predicted to act upstream of or within several process... |
Does Knockout of TRIM10 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 1 | 1,996 | Knockout | TRIM10 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: TRIM10 (tripartite motif containing 10)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes ... |
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