prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of RRS1 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
RRS1
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: RRS1 (regulator of ribosome synthesis 1)
Type: protein-coding
Summary: Enables 5S rRNA binding activity. Involved in several processes, including mitotic metaphase plate congression; protein localization to nucleolus; and ribosomal large subunit assembly. Located in condensed nuclear chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), hematopoietic progenitor cell differentiation, mitotic metaphase chromosome alignment, protein localization to nucleolus, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis; MF: 5S rRNA binding, RNA binding, protein binding; CC: condensed nuclear chromosome, endoplasmic reticulum, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q15050
Entrez ID: 23212
|
Does Knockout of BET1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
BET1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: BET1 (Bet1 golgi vesicular membrane trafficking protein)
Type: protein-coding
Summary: This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, protein binding; CC: Golgi apparatus, Golgi membrane, SNARE complex, cis-Golgi network, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O15155
Entrez ID: 10282
|
Does Knockout of CCDC112 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,631
|
Knockout
|
CCDC112
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: CCDC112 (coiled-coil domain containing 112)
Type: protein-coding
Summary: Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: centriolar satellite, cytoplasm, cytoskeleton
Pathways:
UniProt: Q8NEF3
Entrez ID: 153733
|
Does Knockout of DNMT1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
DNMT1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: DNMT1 (DNA methyltransferase 1)
Type: protein-coding
Summary: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, DNA-templated transcription, cellular response to amino acid stimulus, cellular response to bisphenol A, chromatin organization, chromosomal DNA methylation maintenance following DNA replication, epigenetic programming of gene expression, methylation, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, negative regulation of vascular associated smooth muscle cell apoptotic process, negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching, positive regulation of gene expression, positive regulation of vascular associated smooth muscle cell proliferation, regulation of cell population proliferation, regulation of gene expression; MF: DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA-methyltransferase activity, RNA binding, chromatin binding, lncRNA binding, metal ion binding, methyl-CpG binding, methyltransferase activity, promoter-specific chromatin binding, protein binding, transferase activity, zinc ion binding; CC: female germ cell nucleus, germ cell nucleus, heterochromatin, mitochondrion, nucleoplasm, nucleus, pericentric heterochromatin, replication fork
Pathways: Cystathionine Beta-Synthase Deficiency, Cysteine and methionine metabolism - Homo sapiens (human), DNA methylation, Defective pyroptosis, Disease, Diseases of programmed cell death, Diseases of signal transduction by growth factor receptors and second messengers, Epigenetic regulation of gene expression, Gene expression (Transcription), Glycine N-methyltransferase Deficiency, Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, MTHFR deficiency, Metabolism of proteins, Methionine Adenosyltransferase Deficiency, Methionine Metabolism, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), MicroRNAs in cancer - Homo sapiens (human), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nuclear events stimulated by ALK signaling in cancer, One-carbon metabolism, PRC2 methylates histones and DNA, Post-translational protein modification, Regulation of retinoblastoma protein, Retinoblastoma gene in cancer, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, STAT3 nuclear events downstream of ALK signaling, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA methylation proteins, Signal Transduction, Signaling by ALK, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Receptor Tyrosine Kinases, Trans-sulfuration and one-carbon metabolism, Trans-sulfuration pathway
UniProt: P26358
Entrez ID: 1786
|
Does Knockout of BICDL2 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
BICDL2
|
cell proliferation
|
T-lymphoma cell line
|
Gene: BICDL2 (BICD family like cargo adaptor 2)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and vesicle transport along microtubule. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Golgi to secretory granule transport, vesicle transport along microtubule; MF: protein binding, small GTPase binding
Pathways:
UniProt: A1A5D9
Entrez ID: 146439
|
Does Knockout of CRCP in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
CRCP
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: CRCP (CGRP receptor component)
Type: protein-coding
Summary: This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription initiation, defense response to virus, immune system process, innate immune response, neuropeptide signaling pathway, transcription by RNA polymerase III, transcription initiation at RNA polymerase III promoter; MF: DNA-directed RNA polymerase activity, calcitonin gene-related peptide receptor activity, nucleotide binding, protein binding; CC: DNA polymerase III complex, DNA-directed RNA polymerase complex, RNA polymerase III complex, RNA polymerase complex, acrosomal vesicle, cytosol, membrane, nucleoplasm, nucleus, plasma membrane
Pathways: Cytosolic sensors of pathogen-associated DNA , Gene expression (Transcription), Immune System, Innate Immune System, Myometrial relaxation and contraction pathways, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination
UniProt: O75575
Entrez ID: 27297
|
Does Knockout of RABEP2 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
RABEP2
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: RABEP2 (rabaptin, RAB GTPase binding effector protein 2)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity and growth factor activity. Involved in regulation of cilium assembly. Located in cytosol; intracellular membrane-bounded organelle; and microtubule organizing center. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell projection organization, endocytosis, protein transport, regulation of cilium assembly, signal transduction; MF: GTPase activator activity, growth factor activity, protein binding; CC: Golgi apparatus, cell projection, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, early endosome, endosome, intracellular membrane-bounded organelle
Pathways: 16p11.2 distal deletion syndrome, Ciliary landscape
UniProt: Q9H5N1
Entrez ID: 79874
|
Does Knockout of ATF4 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
ATF4
|
cell proliferation
|
T-lymphoma cell line
|
Gene: ATF4 (activating transcription factor 4)
Type: protein-coding
Summary: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: GDF15-GFRAL signaling pathway, HRI-mediated signaling, L-asparagine metabolic process, PERK-mediated unfolded protein response, bone mineralization, cellular response to UV, cellular response to amino acid starvation, cellular response to glucose starvation, cellular response to hypoxia, cellular response to leucine starvation, cellular response to oxidative stress, circadian regulation of gene expression, circadian rhythm, embryonic hemopoiesis, endoplasmic reticulum unfolded protein response, gamma-aminobutyric acid signaling pathway, gluconeogenesis, integrated stress response signaling, intracellular calcium ion homeostasis, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, lens fiber cell morphogenesis, mRNA transcription by RNA polymerase II, mitochondrial respirasome assembly, negative regulation of cold-induced thermogenesis, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of potassium ion transport, negative regulation of transcription by RNA polymerase II, negative regulation of translational initiation in response to stress, neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of biomineral tissue development, positive regulation of gene expression, positive regulation of neuron apoptotic process, positive regulation of sodium-dependent phosphate transport, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular endothelial growth factor production, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of osteoblast differentiation, regulation of synaptic plasticity, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to manganese-induced endoplasmic reticulum stress, response to nutrient levels, response to toxic substance, rhythmic process, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding protein binding, general transcription initiation factor binding, identical protein binding, leucine zipper domain binding, promoter-specific chromatin binding, protein binding, protein heterodimerization activity, protein kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: ATF1-ATF4 transcription factor complex, ATF4-CREB1 transcription factor complex, CHOP-ATF4 complex, Lewy body core, RNA polymerase II transcription regulator complex, centrosome, chromatin, cytoplasm, cytoskeleton, cytosol, dendrite membrane, membrane, mitochondrion, neuron projection, nuclear periphery, nuclear speck, nucleoplasm, nucleus, plasma membrane, protein-containing complex, transcription regulator complex
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, ATF6 (ATF6-alpha) activates chaperone genes, ATF6 (ATF6-alpha) activates chaperones, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alcoholism - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Amphetamine addiction - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis - Homo sapiens (human), Cellular response to chemical stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Cholinergic synapse - Homo sapiens (human), Cocaine addiction - Homo sapiens (human), Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Dopaminergic synapse - Homo sapiens (human), Estrogen signaling pathway - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glucagon signaling pathway - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Joubert Syndrome, KEAP1-NFE2L2 pathway, Lipid and atherosclerosis - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), Longevity regulating pathway - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mitophagy - animal - Homo sapiens (human), Myometrial relaxation and contraction pathways, NFE2L2 regulating ER-stress associated genes, NFE2L2 regulating anti-oxidant/detoxification enzymes, Neurotrophin signaling pathway - Homo sapiens (human), Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Nuclear events mediated by NFE2L2, PERK regulates gene expression, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Photodynamic therapy-induced unfolded protein response, Prion disease - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Renin-angiotensin-aldosterone system (RAAS), Response of EIF2AK1 (HRI) to heme deficiency, Response of EIF2AK4 (GCN2) to amino acid deficiency, TNF signaling pathway - Homo sapiens (human), Thyroid hormone synthesis - Homo sapiens (human), Unfolded Protein Response (UPR), Unfolded protein response, VEGFA-VEGFR2 Signaling Pathway, Validated transcriptional targets of AP1 family members Fra1 and Fra2, Viral carcinogenesis - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P18848
Entrez ID: 468
|
Does Knockout of PALM3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
PALM3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PALM3 (paralemmin 3)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Involved in Toll signaling pathway; negative regulation of cytokine-mediated signaling pathway; and response to lipopolysaccharide. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Toll signaling pathway, negative regulation of cytokine-mediated signaling pathway, regulation of cell shape, response to lipopolysaccharide; MF: ATP binding, nucleotide binding, protein binding; CC: cytoplasm, membrane, plasma membrane
Pathways:
UniProt: A6NDB9
Entrez ID: 342979
|
Does Knockout of HSPA13 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
HSPA13
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: HSPA13 (heat shock protein family A (Hsp70) member 13)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: protein folding, protein refolding; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, heat shock protein binding, nucleotide binding, protein binding, protein folding chaperone; CC: cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, intracellular membrane-bounded organelle, nucleus, plasma membrane
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: P48723
Entrez ID: 6782
|
Does Knockout of SIAH3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
SIAH3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: SIAH3 (siah E3 ubiquitin protein ligase family member 3)
Type: protein-coding
Summary: Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in negative regulation of protein targeting to mitochondrion and regulation of protein stability. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of protein targeting to mitochondrion, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of protein stability, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, mitochondrion, nucleoplasm
Pathways:
UniProt: Q8IW03
Entrez ID: 283514
|
Does Knockout of LAS1L in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
LAS1L
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: LAS1L (LAS1 like ribosome biogenesis factor)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in membrane. Part of MLL1 complex. Implicated in Wilson-Turner syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing; MF: RNA binding, endonuclease activity, hydrolase activity, protein binding; CC: Las1 complex, MLL1 complex, cytoplasm, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y4W2
Entrez ID: 81887
|
Does Knockout of SMIM14 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
SMIM14
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SMIM14 (small integral membrane protein 14)
Type: protein-coding
Summary: Predicted to act upstream of or within blastocyst hatching. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q96QK8
Entrez ID: 201895
|
Does Knockout of CCDC124 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
CCDC124
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: CCDC124 (coiled-coil domain containing 124)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in cell division. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, positive regulation of DNA-templated transcription, transcription by RNA polymerase II; MF: RNA binding, protein binding, transcription coactivator activity; CC: centrosome, cytoplasm, cytoskeleton, cytosol, midbody, nucleus, plasma membrane
Pathways: VEGFA-VEGFR2 Signaling Pathway
UniProt: Q96CT7
Entrez ID: 115098
|
Does Knockout of RFFL in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
RFFL
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase)
Type: protein-coding
Summary: Enables enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in cellular protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; and negative regulation of signal transduction. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, intracellular protein transport, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of signal transduction by p53 class mediator, negative regulation of tumor necrosis factor-mediated signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein ubiquitination, regulation of TOR signaling, regulation of fibroblast migration, regulation of signal transduction by p53 class mediator, ubiquitin-dependent protein catabolic process; MF: metal ion binding, p53 binding, protease binding, protein binding, protein kinase binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, zinc ion binding; CC: Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endosome, endosome membrane, lysosome, membrane, nucleoplasm, plasma membrane, recycling endosome membrane
Pathways: TNF receptor signaling pathway , TNF-alpha signaling pathway, TNFalpha
UniProt: Q8WZ73
Entrez ID: 117584
|
Does Knockout of ADIG in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
ADIG
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: ADIG (adipogenin)
Type: protein-coding
Summary: ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 [PubMed 15567149]; Hong et al., 2005 [PubMed 16132694]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: brown fat cell differentiation, fat cell differentiation, positive regulation of fat cell differentiation, spermatogenesis, white fat cell differentiation; CC: cytoplasm, lipid droplet, membrane, nucleus
Pathways:
UniProt: Q0VDE8
Entrez ID: 149685
|
Does Knockout of MAB21L2 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
MAB21L2
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: MAB21L2 (mab-21 like 2)
Type: protein-coding
Summary: This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: camera-type eye development, cell population proliferation, embryonic body morphogenesis, eye development, nervous system development, positive regulation of cell population proliferation; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9Y586
Entrez ID: 10586
|
Does Knockout of TCTN3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
TCTN3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: TCTN3 (tectonic family member 3)
Type: protein-coding
Summary: This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012].
Gene Ontology: BP: apoptotic process, cell projection organization, cilium assembly, positive regulation of apoptotic process, smoothened signaling pathway; CC: ciliary membrane, membrane, nucleus
Pathways: Anchoring of the basal body to the plasma membrane, Ciliopathies, Cilium Assembly, Genes related to primary cilium development (based on CRISPR), Joubert Syndrome, Organelle biogenesis and maintenance
UniProt: Q6NUS6
Entrez ID: 26123
|
Does Knockout of RIOK2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
RIOK2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: RIOK2 (RIO kinase 2)
Type: protein-coding
Summary: Predicted to enable protein kinase activity. Involved in several processes, including positive regulation of rRNA processing; positive regulation of ribosomal small subunit export from nucleus; and regulation of mitotic metaphase/anaphase transition. Located in cytoplasm. Part of preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of SSU-rRNA, positive regulation of rRNA processing, positive regulation of ribosomal small subunit export from nucleus, protein autophosphorylation, regulation of mitotic metaphase/anaphase transition, ribosomal small subunit biogenesis, ribosome biogenesis; MF: ATP binding, catalytic activity, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9BVS4
Entrez ID: 55781
|
Does Knockout of CHL1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
CHL1
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: CHL1 (cell adhesion molecule L1 like)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: adult locomotory behavior, axon guidance, cell adhesion, cell differentiation, cognition, exploration behavior, negative regulation of neuron apoptotic process, nervous system development, neuron migration, neuron projection development, signal transduction; CC: apical part of cell, dendrite, extracellular exosome, extracellular region, membrane, neuron projection, plasma membrane
Pathways: Axon guidance, CHL1 interactions, Developmental Biology, L1CAM interactions, Nervous system development, Splicing factor NOVA regulated synaptic proteins
UniProt: O00533
Entrez ID: 10752
|
Does Knockout of NUB1 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
NUB1
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: NUB1 (negative regulator of ubiquitin like proteins 1)
Type: protein-coding
Summary: This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, protein ubiquitination, proteolysis involved in protein catabolic process, regulation of ubiquitin-dependent protein catabolic process, response to tumor necrosis factor, response to type II interferon, ubiquitin-dependent protein catabolic process; CC: Lewy body, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9Y5A7
Entrez ID: 51667
|
Does Knockout of PAMR1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
PAMR1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PAMR1 (peptidase domain containing associated with muscle regeneration 1)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q6UXH9
Entrez ID: 25891
|
Does Knockout of PLAU in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
PLAU
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PLAU (plasminogen activator, urokinase)
Type: protein-coding
Summary: This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: blood coagulation, chemotaxis, epidermal growth factor receptor signaling pathway, fibrinolysis, hemostasis, negative regulation of fibrinolysis, negative regulation of plasminogen activation, plasminogen activation, positive regulation of cell migration, positive regulation of epidermal growth factor receptor signaling pathway, proteolysis, regulation of cell adhesion, regulation of cell adhesion mediated by integrin, regulation of cell population proliferation, regulation of fibrinolysis, regulation of integrin-mediated signaling pathway, regulation of plasminogen activation, regulation of smooth muscle cell migration, regulation of smooth muscle cell-matrix adhesion, regulation of wound healing, response to hypoxia, signal transduction, smooth muscle cell migration, urokinase plasminogen activator signaling pathway; MF: hydrolase activity, peptidase activity, protein binding, receptor ligand activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cell surface, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, focal adhesion, plasma membrane, protein complex involved in cell-matrix adhesion, serine protease inhibitor complex, serine-type endopeptidase complex, specific granule membrane, tertiary granule membrane
Pathways: AP-1 transcription factor network, ATF-2 transcription factor network, Beta1 integrin cell surface interactions, Beta2 integrin cell surface interactions, Beta3 integrin cell surface interactions, Beta5 beta6 beta7 and beta8 integrin cell surface interactions, Blood Clotting Cascade, Complement and Coagulation Cascades, Complement and coagulation cascades - Homo sapiens (human), DNA damage response (only ATM dependent), Dissolution of Fibrin Clot, E2F transcription factor network, Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, FGF signaling pathway, Hemostasis, Immune System, Innate Immune System, LncRNA involvement in canonical Wnt signaling and colorectal cancer, Lung fibrosis, MicroRNAs in cancer - Homo sapiens (human), NF-kappa B signaling pathway - Homo sapiens (human), Neutrophil degranulation, Osteopontin Signaling, Osteopontin-mediated events, Prostate cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Senescence and Autophagy in Cancer, Transcriptional misregulation in cancer - Homo sapiens (human), Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling, VEGFA-VEGFR2 Signaling Pathway, Validated transcriptional targets of AP1 family members Fra1 and Fra2, Wnt signaling, Wnt signaling pathway and pluripotency, amb2 Integrin signaling, fibrinolysis pathway, ncRNAs involved in Wnt signaling in hepatocellular carcinoma, platelet amyloid precursor protein pathway
UniProt: P00749
Entrez ID: 5328
|
Does Knockout of STT3B in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
STT3B
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: STT3B (STT3 oligosaccharyltransferase complex catalytic subunit B)
Type: protein-coding
Summary: The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014].
Gene Ontology: BP: ERAD pathway, glycoprotein catabolic process, post-translational protein modification, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, response to unfolded protein; MF: dolichyl-diphosphooligosaccharide-protein glycotransferase activity, glycosyltransferase activity, metal ion binding, oligosaccharyl transferase activity, protein binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex B, protein-containing complex
Pathways: Adaptive Immune System, Asparagine N-linked glycosylation, Co-inhibition by PD-1, Developmental Biology, Disease, Immune System, Infectious disease, Late SARS-CoV-2 Infection Events, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Maturation of spike protein, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Various types of N-glycan biosynthesis - Homo sapiens (human), Viral Infection Pathways
UniProt: Q8TCJ2
Entrez ID: 201595
|
Does Knockout of FAM227A in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
FAM227A
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: FAM227A (family with sequence similarity 227 member A)
Type: protein-coding
Summary: family with sequence similarity 227 member A
Gene Ontology:
Pathways:
UniProt: F5H4B4
Entrez ID: 646851
|
Does Knockout of PCGF6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
PCGF6
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: PCGF6 (polycomb group ring finger 6)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: metal ion binding, protein binding, zinc ion binding; CC: PRC1 complex, PcG protein complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Transcriptional Regulation by E2F6
UniProt: Q9BYE7
Entrez ID: 84108
|
Does Knockout of ARPC4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
ARPC4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: ARPC4 (actin related protein 2/3 complex subunit 4)
Type: protein-coding
Summary: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin filament polymerization, actin nucleation; MF: actin binding, actin filament binding, enzyme binding, protein binding, protein-macromolecule adaptor activity, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, actin cytoskeleton, cell projection, cytoplasm, cytoskeleton, cytosol, extracellular exosome, nucleus, site of double-strand break
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Homo sapiens (human), CDC42 signaling events, Clathrin-mediated endocytosis, Developmental Biology, Disease, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Homo sapiens (human), ErbB1 downstream signaling, FCGR3A-mediated phagocytosis, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania phagocytosis, Membrane Trafficking, Nervous system development, PDGFR-beta signaling pathway, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), RAC1 signaling pathway, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Homo sapiens (human), Vesicle-mediated transport, Yersinia infection - Homo sapiens (human), how does salmonella hijack a cell, role of pi3k subunit p85 in regulation of actin organization and cell migration, y branching of actin filaments
UniProt: P59998
Entrez ID: 10093
|
Does Knockout of RTCB in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
RTCB
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Type: protein-coding
Summary: Enables RNA ligase (ATP) activity and vinculin binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Located in cytosol and nucleoplasm. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA processing, in utero embryonic development, placenta development, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: GTP binding, RNA binding, RNA ligase (GTP) activity, ligase activity, ligase activity, forming phosphoric ester bonds, metal ion binding, nucleotide binding, protein binding, vinculin binding; CC: cytoplasm, cytosol, endoplasmic reticulum membrane, nuclear envelope, nucleoplasm, nucleus, tRNA-splicing ligase complex
Pathways: Metabolism of RNA, Unfolded protein response, tRNA processing, tRNA processing in the nucleus
UniProt: Q9Y3I0
Entrez ID: 51493
|
Does Knockout of IL5RA in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
IL5RA
|
response to virus
|
Huh-7 Cell
|
Gene: IL5RA (interleukin 5 receptor subunit alpha)
Type: protein-coding
Summary: The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: cell surface receptor signaling pathway, cytokine-mediated signaling pathway, eosinophil differentiation, inflammatory response to antigenic stimulus, interleukin-5-mediated signaling pathway, positive regulation of cell population proliferation, positive regulation of leukocyte proliferation, regulation of interleukin-5 production, signal transduction; MF: cytokine binding, cytokine receptor activity, interleukin-5 receptor activity, protein binding; CC: external side of plasma membrane, extracellular space, membrane, plasma membrane, receptor complex
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human), Hematopoietic cell lineage - Homo sapiens (human), IL-3 signaling pathway, IL-5 signaling pathway, IL5, IL5-mediated signaling events, Inflammatory Response Pathway, JAK-STAT signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Regulatory circuits of the STAT3 signaling pathway
UniProt: Q01344
Entrez ID: 3568
|
Does Knockout of WBP1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
WBP1
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: WBP1 (WW domain binding protein 1)
Type: protein-coding
Summary: The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011].
Gene Ontology: MF: WW domain binding, protein binding
Pathways:
UniProt: Q96G27
Entrez ID: 23559
|
Does Knockout of RNPC3 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
RNPC3
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RNPC3 (RNA binding region (RNP1, RRM) containing 3)
Type: protein-coding
Summary: Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 65K protein that is a component of the U12-type spliceosome. This protein contains two RNA recognition motifs (RRMs), suggesting that it may contact one of the small nuclear RNAs of the minor spliceosome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, U12 snRNA binding, nucleic acid binding, pre-mRNA intronic binding; CC: U12-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Minor Pathway
UniProt: Q96LT9
Entrez ID: 55599
|
Does Knockout of BCL9L in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
BCL9L
|
response to virus
|
Hepatoma Cell Line
|
Gene: BCL9L (BCL9 like)
Type: protein-coding
Summary: Enables beta-catenin binding activity. Involved in several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; and positive regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: canonical Wnt signaling pathway, myoblast differentiation, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of epithelial to mesenchymal transition, positive regulation of transcription by RNA polymerase II, regulation of cell morphogenesis, skeletal muscle cell differentiation, somatic stem cell population maintenance, transcription by RNA polymerase II; MF: beta-catenin binding, transcription coactivator activity; CC: beta-catenin-TCF complex, fibrillar center, nucleoplasm, nucleus
Pathways: Deactivation of the beta-catenin transactivating complex, Formation of the beta-catenin:TCF transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q86UU0
Entrez ID: 283149
|
Does Knockout of MFAP1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
MFAP1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MFAP1 (microfibril associated protein 1)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in centrosome; microfibril; and nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: U2-type precatalytic spliceosome, U2-type spliceosomal complex, centrosome, microfibril, nucleoplasm, nucleus, spliceosomal complex
Pathways: Canonical and non-canonical Notch signaling, Ciliary landscape, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P55081
Entrez ID: 4236
|
Does Knockout of NOX1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
NOX1
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: NOX1 (NADPH oxidase 1)
Type: protein-coding
Summary: This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: JNK cascade, MAPK cascade, NADP+ metabolic process, angiogenesis, cell migration, cellular response to hyperoxia, defense response, extracellular matrix organization, hydrogen peroxide metabolic process, inflammatory response, intrinsic apoptotic signaling pathway in response to oxidative stress, oxygen metabolic process, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of cell population proliferation, positive regulation of integrin biosynthetic process, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of smooth muscle cell proliferation, positive regulation of vascular endothelial growth factor production, regulation of blood pressure, regulation of systemic arterial blood pressure by renin-angiotensin, respiratory burst, signal transduction, superoxide anion generation; MF: NAD(P)H oxidase H2O2-forming activity, NADP binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor, protein binding, small GTPase binding, superoxide-generating NAD(P)H oxidase activity, superoxide-generating NADPH oxidase activity; CC: NADPH oxidase complex, anchoring junction, cell projection, cytoplasm, early endosome, endosome, membrane, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Disease, Fluid shear stress and atherosclerosis - Homo sapiens (human), IL-18 signaling pathway, Infectious disease, Killing mechanisms, Leishmania infection, Lipid and atherosclerosis - Homo sapiens (human), Osteoclast differentiation - Homo sapiens (human), Oxidative Stress, Parasitic Infection Pathways, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), RAC1 GTPase cycle, RAC1 signaling pathway, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate NADPH Oxidases, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TNF-alpha signaling pathway, Vitamin D Receptor Pathway, WNT5:FZD7-mediated leishmania damping
UniProt: Q9Y5S8
Entrez ID: 27035
|
Does Knockout of NHLRC2 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
NHLRC2
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: NHLRC2 (NHL repeat containing 2)
Type: protein-coding
Summary: Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, cytosol, extracellular region, platelet alpha granule lumen
Pathways:
UniProt: Q8NBF2
Entrez ID: 374354
|
Does Knockout of MYC in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
MYC
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: MYC (MYC proto-oncogene, bHLH transcription factor)
Type: protein-coding
Summary: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: B cell apoptotic process, DNA damage response, ERK1 and ERK2 cascade, G1/S transition of mitotic cell cycle, MAPK cascade, NK T cell proliferation, Wnt signaling pathway, acinar cell proliferation, branching involved in ureteric bud morphogenesis, cell population proliferation, cellular response to UV, cellular response to hypoxia, cellular response to interferon-alpha, cellular response to xenobiotic stimulus, chromatin remodeling, chromosome organization, detection of mechanical stimulus involved in sensory perception of sound, fibroblast apoptotic process, intracellular iron ion homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, middle ear morphogenesis, myotube differentiation, negative regulation of apoptotic process, negative regulation of cell division, negative regulation of fibroblast proliferation, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of monocyte differentiation, negative regulation of stress-activated MAPK cascade, negative regulation of transcription by RNA polymerase II, negative regulation of transcription initiation by RNA polymerase II, pigmentation, positive regulation of B cell apoptotic process, positive regulation of DNA-templated transcription, positive regulation of acinar cell proliferation, positive regulation of apoptotic signaling pathway, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of mesenchymal cell proliferation, positive regulation of metanephric cap mesenchymal cell proliferation, positive regulation of miRNA transcription, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein processing, protein-DNA complex disassembly, rRNA metabolic process, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle process, regulation of gene expression, regulation of somatic stem cell population maintenance, regulation of telomere maintenance, regulation of transcription by RNA polymerase II, response to alkaloid, response to growth factor, response to radiation, response to xenobiotic stimulus, skeletal muscle cell differentiation, skeletal system morphogenesis, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SCF ubiquitin ligase complex binding, cis-regulatory region sequence-specific DNA binding, core promoter sequence-specific DNA binding, identical protein binding, protein binding, protein dimerization activity, protein-containing complex binding, transcription coregulator binding, ubiquitin protein ligase binding; CC: Myc-Max complex, RNA polymerase II transcription repressor complex, axon, chromatin, chromosome, cytoplasm, euchromatin, nuclear body, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex, spindle
Pathways: 3q29 copy number variation syndrome, AP-1 transcription factor network, Acute myeloid leukemia - Homo sapiens (human), Adaptive Immune System, Adherens junctions interactions, Apoptosis, Aryl Hydrocarbon Receptor Netpath, Association Between Physico-Chemical Features and Toxicity Associated Pathways, B Cell Receptor Signaling Pathway, Binding of TCF/LEF:CTNNB1 to target gene promoters, Bladder cancer, Bladder cancer - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, C-MYB transcription factor network, C-MYC pathway, CD40/CD40L signaling, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Homo sapiens (human), Central carbon metabolism in cancer - Homo sapiens (human), Ceramide signaling pathway, Chromosomal and microsatellite instability in colorectal cancer, Chronic myeloid leukemia - Homo sapiens (human), Co-inhibition by PD-1, Colorectal cancer - Homo sapiens (human), Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA damage response, DNA damage response (only ATM dependent), Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, E2F transcription factor network, EGFR Tyrosine Kinase Inhibitor Resistance, EGFR1, ESR-mediated signaling, Ectoderm Differentiation, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), Estrogen-dependent gene expression, FOXM1 transcription factor network, Formation of the beta-catenin:TCF transactivating complex, G0 and Early G1, G1 to S cell cycle control, G1/S Transition, Gastric Cancer Network 2, Gastric cancer - Homo sapiens (human), Gastrin signaling pathway, Gene expression (Transcription), Generic Transcription Pathway, Glutaminolysis and Cancer, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Hepatitis C and Hepatocellular Carcinoma, Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), IL-2 signaling pathway, IL-5 signaling pathway, IL-7 signaling pathway, IL2 signaling events mediated by PI3K, IL2 signaling events mediated by STAT5, IL2-mediated signaling events, IL6-mediated signaling events, Imatinib and Chronic Myeloid Leukemia, Immune System, Integrated Cancer Pathway, Integrated breast cancer pathway, Interleukin-4 and Interleukin-13 signaling, JAK-STAT signaling pathway - Homo sapiens (human), KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), LKB1 signaling events, LncRNA involvement in canonical Wnt signaling and colorectal cancer, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK pathway in congenital thyroid cancer, MAPK signaling pathway - Homo sapiens (human), MAPK6/MAPK4 signaling, Mammary gland development pathway - Embryonic development (Stage 1 of 4), Mammary gland development pathway - Involution (Stage 4 of 4), Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4), Mammary gland development pathway - Puberty (Stage 2 of 4), Metabolism of proteins, Metastatic brain tumor, MicroRNAs in cancer - Homo sapiens (human), Mitotic G1 phase and G1/S transition, NOTCH1 Intracellular Domain Regulates Transcription, Neural Crest Differentiation, Notch Signaling Pathway Netpath, Notch signaling pathway, Nuclear Receptors Meta-Pathway, Nuclear events mediated by NFE2L2, PDGFR-beta signaling pathway, PI3K-AKT-mTOR - VitD3 signaling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PPAR-alpha pathway, Pathways affected in adenoid cystic carcinoma, Pathways in cancer - Homo sapiens (human), Post-translational protein modification, Presenilin action in Notch and Wnt signaling, Prolactin Signaling Pathway, Proteoglycans in cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, RNA Polymerase II Transcription, RUNX3 regulates WNT signaling, Regulation of CDH1 Expression and Function, Regulation of CDH1 mRNA translation by microRNAs, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of NFE2L2 gene expression, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Regulation of Telomerase, Regulation of apoptosis by parathyroid hormone-related protein, Regulation of nuclear SMAD2/3 signaling, Regulation of nuclear beta catenin signaling and target gene transcription, Retinoblastoma gene in cancer, S Phase, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by ALK, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Spinal Cord Injury, Structural Pathway of Interleukin 1 (IL-1), TCF dependent signaling in response to WNT, TFAP2 (AP-2) family regulates transcription of cell cycle factors, TGF-beta Signaling Pathway, TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, TP53 network, Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, Thyroid cancer - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid stimulating hormone (TSH) signaling pathway, Transcription of E2F targets under negative control by DREAM complex, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional misregulation in cancer - Homo sapiens (human), Transcriptional regulation by RUNX3, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Transcriptional regulation of granulopoiesis, Ub-specific processing proteases, Validated nuclear estrogen receptor alpha network, Validated targets of C-MYC transcriptional activation, Validated targets of C-MYC transcriptional repression, Vitamin D Receptor Pathway, Wnt Signaling Pathway, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, Wnt-beta-catenin signaling pathway in leukemia, cadmium induces dna synthesis and proliferation in macrophages, ctcf: first multivalent nuclear factor, erk1/erk2 mapk signaling pathway, inhibition of cellular proliferation by gleevec, let-7 inhibition of ES cell reprogramming, mapkinase signaling pathway, mechanism of gene regulation by peroxisome proliferators via ppara, miRNA regulation of DNA damage response, miRNAs involved in DNA damage response, ncRNAs involved in Wnt signaling in hepatocellular carcinoma, overview of telomerase protein component gene htert transcriptional regulation, p38 MAPK Signaling Pathway, p38 mapk signaling pathway, p73 transcription factor network, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, telomeres telomerase cellular aging and immortality, tumor suppressor arf inhibits ribosomal biogenesis, wnt signaling pathway
UniProt: P01106
Entrez ID: 4609
|
Does Knockout of GTF2B in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
GTF2B
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: GTF2B (general transcription factor IIB)
Type: protein-coding
Summary: This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase II core complex assembly, RNA polymerase II preinitiation complex assembly, chromatin remodeling, chromosome organization, gene expression, meiotic sister chromatid cohesion, positive regulation of core promoter binding, protein acetylation, spindle assembly, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription preinitiation complex assembly, transcriptional start site selection at RNA polymerase II promoter, viral transcription; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase II complex binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, acetyltransferase activity, acyltransferase activity, histone acetyltransferase activity, metal ion binding, nuclear thyroid hormone receptor binding, promoter-specific chromatin binding, protein binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: RNA polymerase II transcription regulator complex, cell division site, chromosome, condensed chromosome, germinal vesicle, kinetochore, nuclear body, nucleoplasm, nucleus, protein-DNA complex, transcription factor TFIID complex, transcription preinitiation complex
Pathways: Basal transcription factors - Homo sapiens (human), Disease, Eukaryotic Transcription Initiation, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Spinocerebellar ataxia - Homo sapiens (human), Transcription of the HIV genome, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), chromatin remodeling by hswi/snf atp-dependent complexes, the information processing pathway at the ifn beta enhancer
UniProt: Q00403
Entrez ID: 2959
|
Does Knockout of TRMT10C in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
TRMT10C
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TRMT10C (tRNA methyltransferase 10C, mitochondrial RNase P subunit)
Type: protein-coding
Summary: This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: mRNA processing, methylation, mitochondrial RNA 5'-end processing, mitochondrial tRNA 3'-end processing, mitochondrial tRNA 5'-end processing, mitochondrial tRNA methylation, mitochondrial tRNA processing, positive regulation of mitochondrial translation, tRNA processing; MF: RNA binding, identical protein binding, methyltransferase activity, protein binding, tRNA (adenine(9)-N1)-methyltransferase activity, tRNA (guanosine(9)-N1)-methyltransferase activity, tRNA binding, transferase activity; CC: mitochondrial matrix, mitochondrial nucleoid, mitochondrial ribonuclease P complex, mitochondrion, nucleoplasm, nucleus, tRNA methyltransferase complex
Pathways: Metabolism of RNA, rRNA processing, rRNA processing in the mitochondrion, tRNA modification in the mitochondrion, tRNA processing, tRNA processing in the mitochondrion
UniProt: Q7L0Y3
Entrez ID: 54931
|
Does Knockout of C8orf48 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
C8orf48
|
cell proliferation
|
Cancer Cell Line
|
Gene: C8orf48 (chromosome 8 open reading frame 48)
Type: protein-coding
Summary: chromosome 8 open reading frame 48
Gene Ontology:
Pathways:
UniProt: Q96LL4
Entrez ID: 157773
|
Does Knockout of MOB4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
MOB4
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: MOB4 (MOB family member 4, phocein)
Type: protein-coding
Summary: This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011].
Gene Ontology: MF: metal ion binding, protein binding, protein-macromolecule adaptor activity; CC: FAR/SIN/STRIPAK complex, Golgi apparatus, Golgi cisterna membrane, cytoplasm, glutamatergic synapse, membrane, perinuclear region of cytoplasm, postsynapse
Pathways:
UniProt: Q9Y3A3
Entrez ID: 25843
|
Does Knockout of RBX1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
RBX1
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: RBX1 (ring-box 1)
Type: protein-coding
Summary: This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010].
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, G1/S transition of mitotic cell cycle, MAPK cascade, RNA polymerase II transcription initiation surveillance, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, T cell activation, TORC1 signaling, apoptotic process, autophagosome assembly, base-excision repair, AP site formation via deaminated base removal, cellular response to UV, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to chemical stress, cellular response to insulin stimulus, cellular response to nutrient levels, cellular response to oxidative stress, cytokine-mediated signaling pathway, epithelial to mesenchymal transition, insulin receptor signaling pathway, lysosome organization, miRNA-mediated gene silencing by mRNA destabilization, mitophagy, negative regulation of TORC1 signaling, negative regulation of autophagy, negative regulation of canonical NF-kappaB signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of insulin receptor signaling pathway, negative regulation of mitophagy, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of response to oxidative stress, negative regulation of signal transduction by p53 class mediator, negative regulation of type I interferon production, negative regulation of ubiquitin-dependent protein catabolic process, p38MAPK cascade, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of epithelial cell apoptotic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein autoubiquitination, positive regulation of protein catabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of translation, positive regulation of type I interferon production, post-translational protein modification, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein catabolic process, protein monoubiquitination, protein neddylation, protein polyubiquitination, protein ubiquitination, regulation of cellular response to insulin stimulus, regulation of mitotic cell cycle, renal sodium ion absorption, response to oxidative stress, signal transduction in response to DNA damage, spermatogenesis, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription-coupled nucleotide-excision repair, type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: NEDD8 ligase activity, NEDD8 transferase activity, RNA polymerase II-specific DNA-binding transcription factor binding, cullin family protein binding, metal ion binding, molecular adaptor activity, protein binding, protein-containing complex binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, zinc ion binding; CC: Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, Cul5-RING ubiquitin ligase complex, Cul7-RING ubiquitin ligase complex, SCF ubiquitin ligase complex, VCB complex, cullin-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus, site of DNA damage
Pathways: 22q11.2 copy number variation syndrome, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Axon guidance, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Circadian rhythm - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Cytokine Signaling in Immune system, DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dual Incision in GG-NER, Dual hijack model of Vif in HIV infection, Dual incision in TC-NER, Evasion by RSV of host interferon responses, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FBXW7 Mutants and NOTCH1 in Cancer, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, G1/S DNA Damage Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIF-1 signaling pathway - Homo sapiens (human), HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hijack of ubiquitination by SARS-CoV-2, Hippo-Merlin Signaling Dysregulation, Host Interactions of HIV factors, Human immunodeficiency virus 1 infection - Homo sapiens (human), Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, Immune System, Infectious disease, Interleukin-1 family signaling, Interleukin-1 signaling, KEAP1-NFE2L2 pathway, Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Metabolism of proteins, Mitotic G2-G2/M phases, NOTCH1 Intracellular Domain Regulates Transcription, NRF2-ARE regulation, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Notch, Nuclear events mediated by NFE2L2, Nuclear events stimulated by ALK signaling in cancer, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Pathways in cancer - Homo sapiens (human), Post-translational protein modification, Potential therapeutics for SARS, Prolactin receptor signaling, Protein processing in endoplasmic reticulum - Homo sapiens (human), RAF/MAP kinase cascade, RNA Polymerase II Transcription, RSV-host interactions, Recognition of DNA damage by PCNA-containing replication complex, Regulation of BACH1 activity, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of T cell activation by CD28 family, Regulation of expression of SLITs and ROBOs, Renal cell carcinoma - Homo sapiens (human), Respiratory Syncytial Virus Infection Pathway, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SARS-CoV Infections, SPOP-mediated proteasomal degradation of PD-L1(CD274), Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TGF-beta Signaling Pathway, TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional regulation by RUNX2, Translation, Type 2 papillary renal cell carcinoma, Ubiquitin mediated proteolysis - Homo sapiens (human), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Wnt signaling pathway - Homo sapiens (human), er associated degradation (erad) pathway, p53-Independent G1/S DNA Damage Checkpoint, regulation of p27 phosphorylation during cell cycle progression
UniProt: P62877
Entrez ID: 9978
|
Does Knockout of CCNB1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
CCNB1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: CCNB1 (cyclin B1)
Type: protein-coding
Summary: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, cell division, cellular response to fatty acid, cellular response to hypoxia, cellular response to iron(III) ion, digestive tract development, in utero embryonic development, mitotic cell cycle phase transition, mitotic metaphase chromosome alignment, mitotic spindle organization, negative regulation of gene expression, oocyte maturation, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of attachment of spindle microtubules to kinetochore, positive regulation of cardiac muscle cell proliferation, positive regulation of cell cycle, positive regulation of fibroblast proliferation, positive regulation of mRNA 3'-end processing, positive regulation of mitochondrial ATP synthesis coupled electron transport, positive regulation of mitotic cell cycle, protein-containing complex assembly, regulation of chromosome condensation, regulation of mitotic cell cycle spindle assembly checkpoint, response to DDT, response to mechanical stimulus, response to toxic substance, response to xenobiotic stimulus, spermatogenesis, tissue regeneration, ventricular cardiac muscle cell development; MF: cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase regulator activity, patched binding, protein binding, protein kinase binding, ubiquitin-like protein ligase binding; CC: centrosome, cyclin B1-CDK1 complex, cytoplasm, cytoskeleton, cytosol, membrane, microtubule organizing center, mitochondrial matrix, nucleoplasm, nucleus, outer kinetochore, spindle pole
Pathways: AMP-activated protein kinase (AMPK) signaling, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of mitotic proteins, ATM Signaling Pathway, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NIMA Kinases NEK9, NEK6, NEK7, C-MYB transcription factor network, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Condensation of Prometaphase Chromosomes, Condensation of Prophase Chromosomes, Cyclin A/B1/B2 associated events during G2/M transition, DNA damage response, Depolymerization of the Nuclear Lamina, Developmental Biology, Direct p53 effectors, Disease, Diseases of signal transduction by growth factor receptors and second messengers, E2F mediated regulation of DNA replication, E2F-enabled inhibition of pre-replication complex formation, FOXM1 transcription factor network, FoxO family signaling, FoxO signaling pathway - Homo sapiens (human), G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M DNA replication checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, Golgi Cisternae Pericentriolar Stack Reorganization, Hedgehog, Human immunodeficiency virus 1 infection - Homo sapiens (human), Initiation of Nuclear Envelope (NE) Reformation, M Phase, MASTL Facilitates Mitotic Progression, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear events stimulated by ALK signaling in cancer, Oocyte meiosis - Homo sapiens (human), PLK1 signaling events, Phosphorylation of Emi1, Phosphorylation of the APC/C, Polo-like kinase mediated events, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation, Regulation of PLK1 Activity at G2/M Transition, Regulation of mitotic cell cycle, Resolution of Sister Chromatid Cohesion, Retinoblastoma gene in cancer, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional Regulation by TP53, Transcriptional regulation by RUNX2, Validated targets of C-MYC transcriptional activation, akap95 role in mitosis and chromosome dynamics, cell cycle: g2/m checkpoint, cyclins and cell cycle regulation, estrogen responsive protein efp controls cell cycle and breast tumors growth, how progesterone initiates the oocyte maturation, il-2 receptor beta chain in t cell activation, miRNA regulation of DNA damage response, p53 signaling pathway - Homo sapiens (human), p73 transcription factor network, regulation of cell cycle progression by plk3, sonic hedgehog receptor ptc1 regulates cell cycle, stathmin and breast cancer resistance to antimicrotubule agents
UniProt: P14635
Entrez ID: 891
|
Does Knockout of MYC in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
MYC
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: MYC (MYC proto-oncogene, bHLH transcription factor)
Type: protein-coding
Summary: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: B cell apoptotic process, DNA damage response, ERK1 and ERK2 cascade, G1/S transition of mitotic cell cycle, MAPK cascade, NK T cell proliferation, Wnt signaling pathway, acinar cell proliferation, branching involved in ureteric bud morphogenesis, cell population proliferation, cellular response to UV, cellular response to hypoxia, cellular response to interferon-alpha, cellular response to xenobiotic stimulus, chromatin remodeling, chromosome organization, detection of mechanical stimulus involved in sensory perception of sound, fibroblast apoptotic process, intracellular iron ion homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, middle ear morphogenesis, myotube differentiation, negative regulation of apoptotic process, negative regulation of cell division, negative regulation of fibroblast proliferation, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of monocyte differentiation, negative regulation of stress-activated MAPK cascade, negative regulation of transcription by RNA polymerase II, negative regulation of transcription initiation by RNA polymerase II, pigmentation, positive regulation of B cell apoptotic process, positive regulation of DNA-templated transcription, positive regulation of acinar cell proliferation, positive regulation of apoptotic signaling pathway, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of mesenchymal cell proliferation, positive regulation of metanephric cap mesenchymal cell proliferation, positive regulation of miRNA transcription, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein processing, protein-DNA complex disassembly, rRNA metabolic process, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle process, regulation of gene expression, regulation of somatic stem cell population maintenance, regulation of telomere maintenance, regulation of transcription by RNA polymerase II, response to alkaloid, response to growth factor, response to radiation, response to xenobiotic stimulus, skeletal muscle cell differentiation, skeletal system morphogenesis, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SCF ubiquitin ligase complex binding, cis-regulatory region sequence-specific DNA binding, core promoter sequence-specific DNA binding, identical protein binding, protein binding, protein dimerization activity, protein-containing complex binding, transcription coregulator binding, ubiquitin protein ligase binding; CC: Myc-Max complex, RNA polymerase II transcription repressor complex, axon, chromatin, chromosome, cytoplasm, euchromatin, nuclear body, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex, spindle
Pathways: 3q29 copy number variation syndrome, AP-1 transcription factor network, Acute myeloid leukemia - Homo sapiens (human), Adaptive Immune System, Adherens junctions interactions, Apoptosis, Aryl Hydrocarbon Receptor Netpath, Association Between Physico-Chemical Features and Toxicity Associated Pathways, B Cell Receptor Signaling Pathway, Binding of TCF/LEF:CTNNB1 to target gene promoters, Bladder cancer, Bladder cancer - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, C-MYB transcription factor network, C-MYC pathway, CD40/CD40L signaling, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Homo sapiens (human), Central carbon metabolism in cancer - Homo sapiens (human), Ceramide signaling pathway, Chromosomal and microsatellite instability in colorectal cancer, Chronic myeloid leukemia - Homo sapiens (human), Co-inhibition by PD-1, Colorectal cancer - Homo sapiens (human), Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA damage response, DNA damage response (only ATM dependent), Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, E2F transcription factor network, EGFR Tyrosine Kinase Inhibitor Resistance, EGFR1, ESR-mediated signaling, Ectoderm Differentiation, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), Estrogen-dependent gene expression, FOXM1 transcription factor network, Formation of the beta-catenin:TCF transactivating complex, G0 and Early G1, G1 to S cell cycle control, G1/S Transition, Gastric Cancer Network 2, Gastric cancer - Homo sapiens (human), Gastrin signaling pathway, Gene expression (Transcription), Generic Transcription Pathway, Glutaminolysis and Cancer, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Hepatitis C and Hepatocellular Carcinoma, Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), IL-2 signaling pathway, IL-5 signaling pathway, IL-7 signaling pathway, IL2 signaling events mediated by PI3K, IL2 signaling events mediated by STAT5, IL2-mediated signaling events, IL6-mediated signaling events, Imatinib and Chronic Myeloid Leukemia, Immune System, Integrated Cancer Pathway, Integrated breast cancer pathway, Interleukin-4 and Interleukin-13 signaling, JAK-STAT signaling pathway - Homo sapiens (human), KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), LKB1 signaling events, LncRNA involvement in canonical Wnt signaling and colorectal cancer, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK pathway in congenital thyroid cancer, MAPK signaling pathway - Homo sapiens (human), MAPK6/MAPK4 signaling, Mammary gland development pathway - Embryonic development (Stage 1 of 4), Mammary gland development pathway - Involution (Stage 4 of 4), Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4), Mammary gland development pathway - Puberty (Stage 2 of 4), Metabolism of proteins, Metastatic brain tumor, MicroRNAs in cancer - Homo sapiens (human), Mitotic G1 phase and G1/S transition, NOTCH1 Intracellular Domain Regulates Transcription, Neural Crest Differentiation, Notch Signaling Pathway Netpath, Notch signaling pathway, Nuclear Receptors Meta-Pathway, Nuclear events mediated by NFE2L2, PDGFR-beta signaling pathway, PI3K-AKT-mTOR - VitD3 signaling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PPAR-alpha pathway, Pathways affected in adenoid cystic carcinoma, Pathways in cancer - Homo sapiens (human), Post-translational protein modification, Presenilin action in Notch and Wnt signaling, Prolactin Signaling Pathway, Proteoglycans in cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, RNA Polymerase II Transcription, RUNX3 regulates WNT signaling, Regulation of CDH1 Expression and Function, Regulation of CDH1 mRNA translation by microRNAs, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of NFE2L2 gene expression, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Regulation of Telomerase, Regulation of apoptosis by parathyroid hormone-related protein, Regulation of nuclear SMAD2/3 signaling, Regulation of nuclear beta catenin signaling and target gene transcription, Retinoblastoma gene in cancer, S Phase, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by ALK, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Spinal Cord Injury, Structural Pathway of Interleukin 1 (IL-1), TCF dependent signaling in response to WNT, TFAP2 (AP-2) family regulates transcription of cell cycle factors, TGF-beta Signaling Pathway, TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, TP53 network, Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, Thyroid cancer - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid stimulating hormone (TSH) signaling pathway, Transcription of E2F targets under negative control by DREAM complex, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional misregulation in cancer - Homo sapiens (human), Transcriptional regulation by RUNX3, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Transcriptional regulation of granulopoiesis, Ub-specific processing proteases, Validated nuclear estrogen receptor alpha network, Validated targets of C-MYC transcriptional activation, Validated targets of C-MYC transcriptional repression, Vitamin D Receptor Pathway, Wnt Signaling Pathway, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, Wnt-beta-catenin signaling pathway in leukemia, cadmium induces dna synthesis and proliferation in macrophages, ctcf: first multivalent nuclear factor, erk1/erk2 mapk signaling pathway, inhibition of cellular proliferation by gleevec, let-7 inhibition of ES cell reprogramming, mapkinase signaling pathway, mechanism of gene regulation by peroxisome proliferators via ppara, miRNA regulation of DNA damage response, miRNAs involved in DNA damage response, ncRNAs involved in Wnt signaling in hepatocellular carcinoma, overview of telomerase protein component gene htert transcriptional regulation, p38 MAPK Signaling Pathway, p38 mapk signaling pathway, p73 transcription factor network, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, telomeres telomerase cellular aging and immortality, tumor suppressor arf inhibits ribosomal biogenesis, wnt signaling pathway
UniProt: P01106
Entrez ID: 4609
|
Does Knockout of KRTAP9-6 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
KRTAP9-6
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: KRTAP9-6 (keratin associated protein 9-6)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: A8MVA2
Entrez ID: 100507608
|
Does Knockout of GTF3C5 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
GTF3C5
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: GTF3C5 (general transcription factor IIIC subunit 5)
Type: protein-coding
Summary: Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and tRNA transcription by RNA polymerase III. Predicted to act upstream of or within skeletal muscle cell differentiation. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 5S class rRNA transcription by RNA polymerase III, skeletal muscle cell differentiation, tRNA transcription by RNA polymerase III, transcription by RNA polymerase III, transcription initiation at RNA polymerase III promoter; MF: DNA binding, RNA polymerase III general transcription initiation factor activity, RNA polymerase III type 1 promoter sequence-specific DNA binding, RNA polymerase III type 2 promoter sequence-specific DNA binding, protein binding; CC: nucleoplasm, nucleus, transcription factor TFIIIC complex
Pathways: Gene expression (Transcription), RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, rna polymerase iii transcription
UniProt: Q9Y5Q8
Entrez ID: 9328
|
Does Knockout of GRIN1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
GRIN1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)
Type: protein-coding
Summary: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: brain development, calcium ion homeostasis, calcium ion transmembrane import into cytosol, calcium ion transmembrane transport, calcium-mediated signaling, cellular response to amyloid-beta, chemical synaptic transmission, excitatory chemical synaptic transmission, excitatory postsynaptic potential, ionotropic glutamate receptor signaling pathway, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of calcium ion transport into cytosol, positive regulation of excitatory postsynaptic potential, positive regulation of reactive oxygen species biosynthetic process, positive regulation of synaptic transmission, glutamatergic, positive regulation of transcription by RNA polymerase II, propylene metabolic process, protein heterotetramerization, regulation of membrane potential, regulation of monoatomic cation transmembrane transport, regulation of neuronal synaptic plasticity, regulation of synaptic plasticity, response to ethanol, response to glycine, sodium ion transmembrane transport, visual learning; MF: NMDA glutamate receptor activity, amyloid-beta binding, calcium channel activity, calcium ion binding, calmodulin binding, glutamate binding, glutamate-gated calcium ion channel activity, glycine binding, glycine-gated cation channel activity, ligand-gated monoatomic ion channel activity, ligand-gated sodium channel activity, metal ion binding, monoatomic ion channel activity, protein binding, protein-containing complex binding, signaling receptor activity; CC: NMDA selective glutamate receptor complex, cell surface, cytoplasm, dendrite, dendritic spine, endoplasmic reticulum membrane, excitatory synapse, membrane, monoatomic ion channel complex, neuron projection, neurotransmitter receptor complex, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, synapse, synaptic cleft, synaptic membrane, synaptic vesicle, terminal bouton
Pathways: 3-Methylthiofentanyl Action Pathway, Alcoholism - Homo sapiens (human), Alfentanil Action Pathway, Alvimopan Action Pathway, Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amphetamine addiction - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Anileridine Action Pathway, BDNF-TrkB Signaling, Benzocaine Action Pathway, Brain-derived neurotrophic factor (BDNF) signaling pathway, Bupivacaine Action Pathway, Buprenorphine Action Pathway, Calcium signaling pathway - Homo sapiens (human), Carfentanil Action Pathway, Chloroprocaine Action Pathway, Circadian entrainment - Homo sapiens (human), Citalopram Action Pathway, Cocaine Action Pathway, Cocaine addiction - Homo sapiens (human), Codeine Action Pathway, Common Pathways Underlying Drug Addiction, Desipramine Action Pathway, Dezocine Action Pathway, Dibucaine Action Pathway, Dihydromorphine Action Pathway, Dimethylthiambutene Action Pathway, Diphenoxylate Action Pathway, Disruption of postsynaptic signaling by CNV, Escitalopram Action Pathway, Ethylmorphine Action Pathway, Fentanyl Action Pathway, Fluoxetine Action Pathway, Fragile X Syndrome, Glutamatergic synapse - Homo sapiens (human), Heroin Action Pathway, Huntington disease - Homo sapiens (human), Hydrocodone Action Pathway, Hydromorphone Action Pathway, Imipramine Action Pathway, Ketobemidone Action Pathway, Levallorphan Action Pathway, Levobupivacaine Action Pathway, Levomethadyl Acetate Action Action Pathway, Levorphanol Action Pathway, Lidocaine (Local Anaesthetic) Action Pathway, Long-term potentiation - Homo sapiens (human), MECP2 and Associated Rett Syndrome, Mepivacaine Action Pathway, Methadone Action Pathway, Methadone Metabolism Pathway, Methadyl Acetate Action Pathway, Morphine Action Pathway, NO-cGMP-PKG mediated Neuroprotection, Nalbuphine Action Pathway, Naloxone Action Pathway, Naltrexone Action Pathway, Neuroactive ligand-receptor interaction - Homo sapiens (human), Nicotine Action Pathway, Nicotine addiction - Homo sapiens (human), Oxybuprocaine Action Pathway, Oxycodone Action Pathway, Oxymorphone Action Pathway, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Pentazocine Action Pathway, Phosphodiesterases in neuronal function, Prilocaine Action Pathway, Prion disease - Homo sapiens (human), Procaine Action Pathway, Proparacaine Action Pathway, Propoxyphene Action Pathway, Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Remifentanil Action Pathway, Ropivacaine Action Pathway, Spinal Cord Injury, Spinocerebellar ataxia - Homo sapiens (human), Splicing factor NOVA regulated synaptic proteins, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Sufentanil Action Pathway, Synaptic signaling pathways associated with autism spectrum disorder, Tramadol Action Action Pathway, Vitamin D-sensitive calcium signaling in depression, cAMP signaling pathway - Homo sapiens (human), nitric oxide signaling pathway
UniProt: Q05586
Entrez ID: 2902
|
Does Knockout of EED in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
EED
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: EED (embryonic ectoderm development)
Type: protein-coding
Summary: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, chromatin organization, facultative heterochromatin formation, genomic imprinting, heterochromatin formation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, oligodendrocyte differentiation, regulation of adaxial/abaxial pattern formation, spinal cord development; MF: chromatin binding, enzyme activator activity, identical protein binding, nucleosome binding, protein binding, transcription corepressor binding; CC: ESC/E(Z) complex, chromatin silencing complex, chromosome, cytosol, nucleoplasm, nucleus, pronucleus, sex chromatin
Pathways: Epithelial to mesenchymal transition in colorectal cancer, FBXL10 enhancement of MAP-ERK signaling in diffuse large B-cell lymphoma, Histone Modifications, Interactome of polycomb repressive complex 2 (PRC2), TNFalpha, Tumor suppressor activity of SMARCB1, the prc2 complex sets long-term gene silencing through modification of histone tails
UniProt: O75530
Entrez ID: 8726
|
Does Knockout of SP7 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
SP7
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SP7 (Sp7 transcription factor)
Type: protein-coding
Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010].
Gene Ontology: BP: cellular response to zinc ion starvation, cementum mineralization, diphosphate metabolic process, gene expression, hematopoietic stem cell differentiation, osteoblast differentiation, positive regulation of stem cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, response to insulin; MF: DEAD/H-box RNA helicase binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: chromatin, cytoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX2 regulates bone development, RUNX2 regulates osteoblast differentiation, Role of Osx and miRNAs in tooth development, Transcriptional regulation by RUNX2, Type I collagen synthesis in the context of Osteogenesis imperfecta
UniProt: Q8TDD2
Entrez ID: 121340
|
Does Knockout of NACAD in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
NACAD
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: NACAD (NAC alpha domain containing)
Type: protein-coding
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein targeting to membrane, protein transport; MF: protein binding, unfolded protein binding; CC: cytoplasm, nascent polypeptide-associated complex, nucleus
Pathways:
UniProt: O15069
Entrez ID: 23148
|
Does Knockout of TSHZ3 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
TSHZ3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: TSHZ3 (teashirt zinc finger homeobox 3)
Type: protein-coding
Summary: This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: long-term synaptic potentiation, negative regulation of DNA-templated transcription, positive regulation of synaptic transmission, glutamatergic, regulation of gene expression, regulation of respiratory gaseous exchange by nervous system process, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, chromatin binding, metal ion binding, protein binding, zinc ion binding; CC: cell projection, chromatin, growth cone, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q63HK5
Entrez ID: 57616
|
Does Knockout of TAF6L in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
TAF6L
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: TAF6L (TATA-box binding protein associated factor 6 like)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, chromatin remodeling, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of somatic stem cell population maintenance, regulation of transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, protein binding, protein heterodimerization activity, transcription coactivator activity; CC: SAGA complex, SLIK (SAGA-like) complex, extracellular exosome, histone deacetylase complex, nucleoplasm, nucleus, transcription factor TFIID complex
Pathways: Basal transcription factors - Homo sapiens (human), Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9Y6J9
Entrez ID: 10629
|
Does Knockout of CYB5R2 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
CYB5R2
|
response to virus
|
Lung Cancer Cell Line
|
Gene: CYB5R2 (cytochrome b5 reductase 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: bicarbonate transport, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: FAD binding, cytochrome-b5 reductase activity, acting on NAD(P)H, oxidoreductase activity, protein binding; CC: endoplasmic reticulum membrane, membrane, mitochondrion, nucleus
Pathways: Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Oxidation by Cytochrome P450
UniProt: Q6BCY4
Entrez ID: 51700
|
Does Knockout of SNX3 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,430
|
Knockout
|
SNX3
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: SNX3 (sorting nexin 3)
Type: protein-coding
Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: endocytic recycling, host-mediated suppression of symbiont invasion, intralumenal vesicle formation, late endosome to Golgi transport, membrane invagination, negative regulation of early endosome to late endosome transport, negative regulation of phagocytosis, negative regulation of protein catabolic process, negative regulation of protein transport, positive regulation of neuron projection development, protein to membrane docking, protein transport, regulation of Wnt signaling pathway, response to bacterium; MF: lipid binding, phosphatidylinositol binding, phosphatidylinositol phosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding, protein binding, protein phosphatase binding, retromer complex binding; CC: clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, early endosome, early endosome membrane, early phagosome, endosome, endosome membrane, extracellular exosome, phagocytic vesicle, retromer complex
Pathways: Deubiquitination, Endocytosis - Homo sapiens (human), Metabolism of proteins, Post-translational protein modification, Signal Transduction, Signaling by WNT, Ub-specific processing proteases, WNT ligand biogenesis and trafficking
UniProt: O60493
Entrez ID: 8724
|
Does Knockout of GAPVD1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
GAPVD1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: GAPVD1 (GTPase activating protein and VPS9 domains 1)
Type: protein-coding
Summary: Enables GTPase activating protein binding activity and guanyl-nucleotide exchange factor activity. Involved in regulation of protein transport. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endocytosis, regulation of protein transport, vesicle-mediated transport; MF: GTPase activating protein binding, GTPase activator activity, cadherin binding, guanyl-nucleotide exchange factor activity, protein binding, small GTPase binding; CC: cytosol, endocytic vesicle, endosome, membrane, plasma membrane
Pathways: Clathrin-mediated endocytosis, Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q14C86
Entrez ID: 26130
|
Does Knockout of HS6ST1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
HS6ST1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: HS6ST1 (heparan sulfate 6-O-sulfotransferase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: angiogenesis, heparan sulfate proteoglycan biosynthetic process, labyrinthine layer blood vessel development, lung alveolus development, neuron development; MF: heparan sulfate 6-sulfotransferase activity, protein binding, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane, plasma membrane
Pathways: Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human), Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metapathway biotransformation Phase I and II, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: O60243
Entrez ID: 9394
|
Does Knockout of LCMT1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
LCMT1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: LCMT1 (leucine carboxyl methyltransferase 1)
Type: protein-coding
Summary: LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: C-terminal protein methylation, G2/M transition of mitotic cell cycle, methylation, negative regulation of protein-containing complex assembly, protein methylation, protein modification process, regulation of apoptotic process, regulation of glucose metabolic process, regulation of mitotic cell cycle spindle assembly checkpoint, regulation of signal transduction; MF: S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, protein C-terminal carboxyl O-methyltransferase activity, protein C-terminal leucine carboxyl O-methyltransferase activity, protein binding, protein methyltransferase activity, transferase activity; CC: cytosol, nucleoplasm
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Transition, Mitotic G2-G2/M phases
UniProt: Q9UIC8
Entrez ID: 51451
|
Does Knockout of GIMAP5 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
GIMAP5
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: GIMAP5 (GTPase, IMAP family member 5)
Type: protein-coding
Summary: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010].
Gene Ontology: MF: GTP binding, GTPase activity, nucleotide binding, protein binding; CC: endosome, endosome membrane, lysosomal membrane, lysosome, membrane, multivesicular body membrane
Pathways:
UniProt: Q96F15
Entrez ID: 55340
|
Does Knockout of B3GALNT1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
B3GALNT1
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: B3GALNT1 (beta-1,3-N-acetylgalactosaminyltransferase 1 (Globoside blood group))
Type: protein-coding
Summary: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: carbohydrate derivative biosynthetic process, glycosphingolipid biosynthetic process, lipid metabolic process, oligosaccharide biosynthetic process, protein O-linked glycosylation, protein glycosylation; MF: N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity, galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - globo and isoglobo series - Homo sapiens (human), Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human), Glycosphingolipid metabolism, Metabolism, Metabolism of Spingolipids in ER and Golgi apparatus, Metabolism of lipids, Sphingolipid metabolism
UniProt: O75752
Entrez ID: 8706
|
Does Knockout of ESPL1 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
ESPL1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: ESPL1 (extra spindle pole bodies like 1, separase)
Type: protein-coding
Summary: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: apoptotic process, chromosome segregation, establishment of mitotic spindle localization, homologous chromosome segregation, meiosis I, meiotic chromosome separation, meiotic spindle organization, mitotic cell cycle, mitotic cytokinesis, mitotic sister chromatid segregation, mitotic sister chromatid separation, negative regulation of sister chromatid cohesion, nuclear chromosome segregation, nuclear division, positive regulation of mitotic metaphase/anaphase transition, proteolysis; MF: catalytic activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding; CC: centrosome, cytoplasm, cytosol, mitotic spindle, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Oocyte meiosis - Homo sapiens (human), Regulation of sister chromatid separation at the metaphase-anaphase transition, Separation of Sister Chromatids
UniProt: Q14674
Entrez ID: 9700
|
Does Knockout of MYB in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
MYB
|
response to virus
|
Lung Cancer Cell Line
|
Gene: MYB (MYB proto-oncogene, transcription factor)
Type: protein-coding
Summary: This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: B cell differentiation, G1/S transition of mitotic cell cycle, T-helper 2 cell differentiation, calcium ion transport, cellular response to hydrogen peroxide, cellular response to interleukin-6, cellular response to leukemia inhibitory factor, cellular response to retinoic acid, embryonic digestive tract development, erythrocyte differentiation, homeostasis of number of cells, in utero embryonic development, mitotic cell cycle, myeloid cell development, myeloid cell differentiation, negative regulation of DNA-templated transcription, negative regulation of hematopoietic progenitor cell differentiation, negative regulation of megakaryocyte differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of collagen biosynthetic process, positive regulation of glial cell proliferation, positive regulation of hepatic stellate cell activation, positive regulation of hepatic stellate cell proliferation, positive regulation of miRNA transcription, positive regulation of neuron apoptotic process, positive regulation of smooth muscle cell proliferation, positive regulation of testosterone secretion, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta production, regulation of DNA-templated transcription, regulation of gene expression, response to hypoxia, response to ischemia, skeletal muscle cell proliferation, spleen development, stem cell division, thymus development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, WD40-repeat domain binding, protein binding; CC: RNA polymerase II transcription regulator complex, cytosol, nuclear matrix, nucleoplasm, nucleus
Pathways: AP-1 transcription factor network, C-MYB transcription factor network, Developmental Biology, ESR-mediated signaling, EV release from cardiac cells and their functional effects, Estrogen-dependent gene expression, Factors involved in megakaryocyte development and platelet production, Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, Hemostasis, IL2 signaling events mediated by PI3K, IL4-mediated signaling events, Neural Crest Differentiation, Notch-mediated HES/HEY network, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways affected in adenoid cystic carcinoma, Prolactin, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Signal Transduction, Signaling by Nuclear Receptors, Specification of the neural plate border, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Transcriptional regulation by RUNX1, Transcriptional regulation of granulopoiesis
UniProt: P10242
Entrez ID: 4602
|
Does Knockout of PFN1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
PFN1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PFN1 (profilin 1)
Type: protein-coding
Summary: This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: actin cytoskeleton organization, modification of postsynaptic actin cytoskeleton, modulation of chemical synaptic transmission, negative regulation of actin filament bundle assembly, negative regulation of stress fiber assembly, neural tube closure, positive regulation of actin filament bundle assembly, positive regulation of actin filament polymerization, positive regulation of epithelial cell migration, positive regulation of ruffle assembly, protein stabilization, regulation of actin filament organization, regulation of actin filament polymerization, regulation of transcription by RNA polymerase II, synapse maturation; MF: RNA binding, actin binding, actin monomer binding, adenyl-nucleotide exchange factor activity, cadherin binding, phosphatidylinositol-4,5-bisphosphate binding, phosphotyrosine residue binding, proline-rich region binding, protein binding, small GTPase binding; CC: blood microparticle, cell cortex, cytoplasm, cytoskeleton, cytosol, extracellular exosome, focal adhesion, glutamatergic synapse, membrane, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Association Between Physico-Chemical Features and Toxicity Associated Pathways, Axon guidance, Beta-catenin independent WNT signaling, Developmental Biology, EGFR1, G13 Signaling Pathway, Hemostasis, Nervous system development, PCP/CE pathway, Platelet activation, signaling and aggregation, Platelet degranulation , RHO GTPase Effectors, RHO GTPases Activate Formins, Rap1 signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Response to elevated platelet cytosolic Ca2+, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by ROBO receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, VEGFA-VEGFR2 Signaling Pathway, erk and pi-3 kinase are necessary for collagen binding in corneal epithelia, rho cell motility signaling pathway
UniProt: P07737
Entrez ID: 5216
|
Does Knockout of NRAP in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
NRAP
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: NRAP (nebulin related anchoring protein)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity and muscle alpha-actinin binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to be located in fascia adherens; muscle tendon junction; and myofibril. Predicted to be active in Z disc. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: actin binding, actin filament binding, metal ion binding, muscle alpha-actinin binding, protein binding, vinculin binding; CC: Z disc, cytoplasm, fascia adherens, muscle tendon junction, myofibril
Pathways:
UniProt: Q86VF7
Entrez ID: 4892
|
Does Knockout of S1PR2 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
S1PR2
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: S1PR2 (sphingosine-1-phosphate receptor 2)
Type: protein-coding
Summary: This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, actin cytoskeleton organization, adenylate cyclase-activating G protein-coupled receptor signaling pathway, excitatory postsynaptic potential, filopodium assembly, negative regulation of excitatory postsynaptic potential, positive regulation of cell population proliferation, positive regulation of establishment of endothelial barrier, regulation of postsynapse assembly, signal transduction, sphingosine-1-phosphate receptor signaling pathway; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, G protein-coupled receptor binding, integrin binding, lipid binding, protein binding, sphingosine-1-phosphate receptor activity; CC: cytoplasm, glutamatergic synapse, membrane, plasma membrane, postsynapse, presynapse
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Lysosphingolipid and LPA receptors, Neuroactive ligand-receptor interaction - Homo sapiens (human), S1P2 pathway, Signal Transduction, Signal Transduction of S1P Receptor, Signaling by GPCR, Small Ligand GPCRs, Sphingolipid signaling pathway - Homo sapiens (human), Sphingosine 1-phosphate (S1P) pathway
UniProt: O95136
Entrez ID: 9294
|
Does Knockout of NUP98 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
NUP98
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: NUP98 (nucleoporin 98 and 96 precursor)
Type: protein-coding
Summary: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: RNA export from nucleus, mRNA transport, nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, positive regulation of mRNA splicing, via spliceosome, post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery, protein import into nucleus, protein transport, proteolysis, telomere tethering at nuclear periphery; MF: RNA binding, hydrolase activity, mRNA binding, molecular condensate scaffold activity, nuclear localization sequence binding, peptidase activity, peptide binding, promoter-specific chromatin binding, protein binding, serine-type peptidase activity, structural constituent of nuclear pore, transcription coactivator activity; CC: cytosol, kinetochore, membrane, nuclear body, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore cytoplasmic filaments, nuclear pore nuclear basket, nuclear pore outer ring, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Influenza A - Homo sapiens (human), RNA transport - Homo sapiens (human), SARS-CoV-2 innate immunity evasion and cell-specific immune response
UniProt: P52948
Entrez ID: 4928
|
Does Activation of TPST1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
TPST1
|
response to virus
|
Hepatoma Cell Line
|
Gene: TPST1 (tyrosylprotein sulfotransferase 1)
Type: protein-coding
Summary: Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation. Is integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate metabolic process, post-translational protein modification; MF: protein homodimerization activity, protein-tyrosine sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi lumen, Golgi membrane, membrane, trans-Golgi network
Pathways: Biological oxidations, Cytosolic sulfonation of small molecules, Defective F8 sulfation at Y1699, Defective factor VIII causes hemophilia A, Defects of contact activation system (CAS) and kallikrein/kinin system (KKS), Disease, Diseases of hemostasis, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism, Metabolism of proteins, Phase II - Conjugation of compounds, Post-translational protein modification
UniProt: O60507
Entrez ID: 8460
|
Does Knockout of EIF2B4 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
EIF2B4
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)
Type: protein-coding
Summary: Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell receptor signaling pathway, animal organ development, central nervous system development, cytoplasmic translational initiation, myelination, oligodendrocyte development, ovarian follicle development, regulation of translation, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, protein binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Translation, Translation Factors
UniProt: Q9UI10
Entrez ID: 8890
|
Does Knockout of SPEF2 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
SPEF2
|
cell proliferation
|
Bladder Carcinoma
|
Gene: SPEF2 (sperm flagellar 2)
Type: protein-coding
Summary: Involved in sperm axoneme assembly. Located in sperm flagellum. Implicated in spermatogenic failure 43. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: brain morphogenesis, cell differentiation, epithelial cilium movement involved in extracellular fluid movement, respiratory system development, skeletal system morphogenesis, sperm axoneme assembly, spermatogenesis; CC: Golgi apparatus, cell projection, cilium, cytoplasm, cytosol, extracellular region, manchette, motile cilium, nuclear body, sperm flagellum, sperm midpiece
Pathways:
UniProt: Q9C093
Entrez ID: 79925
|
Does Knockout of UBAP2L in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
UBAP2L
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: UBAP2L (ubiquitin associated protein 2 like)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in binding activity of sperm to zona pellucida and stress granule assembly. Acts upstream of or within hematopoietic stem cell homeostasis. Part of PcG protein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: binding of sperm to zona pellucida, hematopoietic stem cell homeostasis, positive regulation of stress granule assembly, stress granule assembly; MF: RNA binding, protein binding; CC: PcG protein complex, chromosome, cytoplasm, cytoplasmic stress granule, nucleus
Pathways: VEGFA-VEGFR2 Signaling Pathway
UniProt: Q14157
Entrez ID: 9898
|
Does Knockout of PPFIA4 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
PPFIA4
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: PPFIA4 (PPFI scaffold protein A4)
Type: protein-coding
Summary: PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family. See liprin-alpha-1 (LIP1, or PPFIA1; MIM 611054) for background on liprins.[supplied by OMIM, Mar 2008].
Gene Ontology: CC: cell surface, cytoplasm, cytosol, presynaptic active zone, synapse
Pathways: Acetylcholine Neurotransmitter Release Cycle, Dopamine Neurotransmitter Release Cycle, Glutamate Neurotransmitter Release Cycle, Neuronal System, Neurotransmitter release cycle, Norepinephrine Neurotransmitter Release Cycle, Protein-protein interactions at synapses, Receptor-type tyrosine-protein phosphatases, Serotonin Neurotransmitter Release Cycle, Transmission across Chemical Synapses
UniProt: O75335
Entrez ID: 8497
|
Does Knockout of GMDS in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
GMDS
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: GMDS (GDP-mannose 4,6-dehydratase)
Type: protein-coding
Summary: GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009].
Gene Ontology: BP: 'de novo' GDP-L-fucose biosynthetic process, GDP-L-fucose biosynthetic process, GDP-mannose metabolic process, Notch signaling pathway; MF: GDP-mannose 4,6-dehydratase activity, NADP+ binding, identical protein binding, lyase activity, protein binding; CC: cytoplasm, cytosol, extracellular exosome
Pathways: Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Fructose and Mannose Degradation, Fructose and mannose metabolism - Homo sapiens (human), Fructose intolerance, hereditary, Fructosuria, GDP-L-fucose biosynthesis I (from GDP-D-mannose), GDP-fucose biosynthesis, Metabolism of proteins, Post-translational protein modification, Synthesis of substrates in N-glycan biosythesis
UniProt: O60547
Entrez ID: 2762
|
Does Activation of ARMC5 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
ARMC5
|
response to virus
|
Hepatoma Cell Line
|
Gene: ARMC5 (armadillo repeat containing 5)
Type: protein-coding
Summary: This gene encodes a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. The ARM repeat is a tandemly repeated sequence motif with approximately 40 amino acid long. This repeat is implicated in mediating protein-protein interactions. The encoded protein contains seven ARM repeats. Mutations in this gene are associated with primary bilateral macronodular adrenal hyperplasia, which is also known as ACTH-independent macronodular adrenal hyperplasia 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: CD4-positive, alpha-beta T cell differentiation, RNA polymerase II transcription initiation surveillance, T cell proliferation, adrenal cortex development, anatomical structure morphogenesis, defense response to virus, gastrulation, hemopoiesis, in utero embryonic development, mesoderm formation, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of steroid biosynthetic process, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, chromatin, chromosome, cytoplasm, cytosol, focal adhesion, membrane, nucleoplasm, nucleus
Pathways: Cushing syndrome - Homo sapiens (human)
UniProt: Q96C12
Entrez ID: 79798
|
Does Knockout of STAG1 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
STAG1
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: STAG1 (STAG1 cohesin complex component)
Type: protein-coding
Summary: This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell division, chromosome segregation, establishment of mitotic sister chromatid cohesion, mitotic spindle assembly, sister chromatid cohesion; MF: chromatin binding, protein binding; CC: chromatin, chromosome, chromosome, centromeric region, cilium, cohesin complex, cytosol, mitotic cohesin complex, mitotic spindle pole, nuclear body, nuclear matrix, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cohesin Loading onto Chromatin, ESR-mediated signaling, Establishment of Sister Chromatid Cohesion, Estrogen-dependent gene expression, M Phase, Meiosis, Meiotic synapsis, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Telophase/Cytokinesis, Post-translational protein modification, Regulation of sister chromatid separation at the metaphase-anaphase transition, Reproduction, Resolution of Sister Chromatid Cohesion, S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q8WVM7
Entrez ID: 10274
|
Does Knockout of PNO1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
PNO1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PNO1 (partner of NOB1 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, nucleic acid binding, protein binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NRX1
Entrez ID: 56902
|
Does Knockout of DGUOK in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
DGUOK
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: DGUOK (deoxyguanosine kinase)
Type: protein-coding
Summary: In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate derivative metabolic process, dAMP salvage, dGTP metabolic process, guanosine metabolic process, mitochondrial ATP synthesis coupled electron transport, negative regulation of neuron projection development, nucleobase-containing compound metabolic process, purine deoxyribonucleoside metabolic process; MF: ATP binding, deoxyadenosine kinase activity, deoxyguanosine kinase activity, deoxynucleoside kinase activity, kinase activity, nucleotide binding, protein binding, transferase activity; CC: cytoplasm, cytosol, mitochondrial matrix, mitochondrion, nucleus
Pathways: AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Gout or Kelley-Seegmiller Syndrome, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide salvage, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Purine salvage, Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, purine deoxyribonucleosides salvage
UniProt: Q16854
Entrez ID: 1716
|
Does Knockout of CCDC86 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
CCDC86
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: CCDC86 (coiled-coil domain containing 86)
Type: protein-coding
Summary: Enables RNA binding activity. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromosome segregation, mitotic nuclear division; MF: RNA binding, protein binding; CC: chromosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9H6F5
Entrez ID: 79080
|
Does Knockout of INS-IGF2 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
INS-IGF2
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: INS-IGF2 (INS-IGF2 readthrough)
Type: protein-coding
Summary: This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: hormone activity, insulin receptor binding; CC: extracellular region, extracellular space
Pathways: AMP-activated protein kinase (AMPK) signaling, Type II diabetes mellitus
UniProt: F8WCM5
Entrez ID: 723961
|
Does Knockout of CA10 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
CA10
|
cell proliferation
|
Bladder Carcinoma
|
Gene: CA10 (carbonic anhydrase 10)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a role in the central nervous system, especially in brain development. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: carbonate dehydratase activity, hydro-lyase activity, zinc ion binding
Pathways:
UniProt: Q9NS85
Entrez ID: 56934
|
Does Knockout of RPL35 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
RPL35
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPL35 (ribosomal protein L35)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation; MF: RNA binding, mRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, membrane, nucleolus, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P42766
Entrez ID: 11224
|
Does Knockout of TAAR2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
TAAR2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TAAR2 (trace amine associated receptor 2)
Type: protein-coding
Summary: Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, trace-amine receptor activity; CC: membrane, plasma membrane
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Other, Neuroactive ligand-receptor interaction - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q9P1P5
Entrez ID: 9287
|
Does Knockout of TMEM62 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
TMEM62
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: TMEM62 (transmembrane protein 62)
Type: protein-coding
Summary: Predicted to enable hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: hydrolase activity, protein binding
Pathways:
UniProt: Q0P6H9
Entrez ID: 80021
|
Does Knockout of CA5B in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
CA5B
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CA5B (carbonic anhydrase 5B)
Type: protein-coding
Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes carbonic anhydrase 5B. CA5B, and the related CA5A gene, has its expression localized in the mitochondria though CA5B has a wider tissue distribution than CA5A, which is restricted to the liver, kidneys, and skeletal muscle. A carbonic anhydrase pseudogene (CA5BP1) is adjacent to the CA5B gene and these two loci produce CA5BP1-CA5B readthrough transcripts. [provided by RefSeq, Jan 2019].
Gene Ontology: MF: carbonate dehydratase activity, lyase activity, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Metabolism, Nitrogen metabolism - Homo sapiens (human), Reversible hydration of carbon dioxide
UniProt: Q9Y2D0
Entrez ID: 11238
|
Does Knockout of GOLGA6L6 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
GOLGA6L6
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: GOLGA6L6 (golgin A6 family like 6 (gene/pseudogene))
Type: protein-coding
Summary: golgin A6 family like 6 (gene/pseudogene)
Gene Ontology:
Pathways:
UniProt: A8MZA4
Entrez ID: 727832
|
Does Knockout of LRRN1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
LRRN1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: LRRN1 (leucine rich repeat neuronal 1)
Type: protein-coding
Summary: Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, signaling receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q6UXK5
Entrez ID: 57633
|
Does Knockout of MC3R in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
MC3R
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MC3R (melanocortin 3 receptor)
Type: protein-coding
Summary: This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, circadian regulation of gene expression, homoiothermy, locomotor rhythm, phospholipase C-activating G protein-coupled receptor signaling pathway, regulation of blood pressure, regulation of feeding behavior, regulation of heart rate, rhythmic process, signal transduction, sodium ion homeostasis; MF: G protein-coupled receptor activity, melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, neuropeptide binding, peptide hormone binding, protein binding; CC: cytoplasm, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Developmental Biology, G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Ghrelin, MITF-M-regulated melanocyte development, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide GPCRs, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Transcriptional and post-translational regulation of MITF-M expression and activity
UniProt: P41968
Entrez ID: 4159
|
Does Knockout of METTL3 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
METTL3
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)
Type: protein-coding
Summary: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, RNA methylation, cell differentiation, cellular response to UV, circadian rhythm, dosage compensation by inactivation of X chromosome, endothelial to hematopoietic transition, forebrain radial glial cell differentiation, gliogenesis, immune system process, innate immune response, mRNA destabilization, mRNA export from nucleus, mRNA modification, mRNA processing, mRNA splicing, via spliceosome, methylation, negative regulation of Notch signaling pathway, negative regulation of type I interferon-mediated signaling pathway, oogenesis, positive regulation of cap-independent translational initiation, positive regulation of translation, primary miRNA processing, regulation of T cell differentiation, regulation of hematopoietic stem cell differentiation, regulation of meiotic cell cycle, rhythmic process, spermatogenesis, stem cell population maintenance; MF: RNA binding, RNA methyltransferase activity, S-adenosyl-L-methionine binding, mRNA binding, mRNA m(6)A methyltransferase activity, methyltransferase activity, protein binding, protein heterodimerization activity, transferase activity; CC: Golgi apparatus, RNA N6-methyladenosine methyltransferase complex, cytoplasm, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus, oxidoreductase complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Processing
UniProt: Q86U44
Entrez ID: 56339
|
Does Knockout of APLP2 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
APLP2
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: APLP2 (amyloid beta precursor like protein 2)
Type: protein-coding
Summary: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, axonogenesis, central nervous system development; MF: DNA binding, heparin binding, identical protein binding, metal ion binding, peptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity, transition metal ion binding; CC: endoplasmic reticulum lumen, extracellular exosome, membrane, nucleus, plasma membrane, platelet alpha granule, platelet alpha granule membrane
Pathways: EGFR1, Splicing factor NOVA regulated synaptic proteins
UniProt: Q06481
Entrez ID: 334
|
Does Knockout of THG1L in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
THG1L
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: THG1L (tRNA-histidine guanylyltransferase 1 like)
Type: protein-coding
Summary: The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: mitochondrial fusion, protein homotetramerization, response to oxidative stress, stress-induced mitochondrial fusion, tRNA 5'-end processing, tRNA modification, tRNA processing; MF: ATP binding, GTP binding, guanyl-nucleotide exchange factor activity, identical protein binding, magnesium ion binding, metal ion binding, nucleotide binding, nucleotidyltransferase activity, protein binding, tRNA binding, tRNA guanylyltransferase activity, transferase activity; CC: cytoplasm, cytosol, membrane, mitochondrial outer membrane, mitochondrion, transferase complex
Pathways: Metabolism of RNA, tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q9NWX6
Entrez ID: 54974
|
Does Knockout of RELA in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
RELA
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: RELA (RELA proto-oncogene, NF-kB subunit)
Type: protein-coding
Summary: NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: DNA-templated transcription, animal organ morphogenesis, antiviral innate immune response, canonical NF-kappaB signal transduction, cellular defense response, cellular response to angiotensin, cellular response to hepatocyte growth factor stimulus, cellular response to hydrogen peroxide, cellular response to interleukin-1, cellular response to interleukin-6, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to nicotine, cellular response to peptidoglycan, cellular response to tumor necrosis factor, chromatin organization, cytokine-mediated signaling pathway, defense response, defense response to tumor cell, defense response to virus, hair follicle development, inflammatory response, innate immune response, interleukin-1-mediated signaling pathway, intracellular signal transduction, liver development, negative regulation of DNA-templated transcription, negative regulation of angiogenesis, negative regulation of apoptotic process, negative regulation of cytokine production, negative regulation of cytokine production involved in inflammatory response, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of insulin receptor signaling pathway, negative regulation of miRNA transcription, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of protein catabolic process, negative regulation of protein sumoylation, negative regulation of transcription by RNA polymerase II, neuropeptide signaling pathway, non-canonical NF-kappaB signal transduction, nucleotide-binding oligomerization domain containing 2 signaling pathway, positive regulation of DNA-templated transcription, positive regulation of NF-kappaB transcription factor activity, positive regulation of Schwann cell differentiation, positive regulation of T cell receptor signaling pathway, positive regulation of amyloid-beta formation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of interleukin-1 beta production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of miRNA metabolic process, positive regulation of miRNA transcription, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial growth factor production, postsynapse to nucleus signaling pathway, prolactin signaling pathway, protein catabolic process, regulation of DNA-templated transcription, regulation of inflammatory response, regulation of transcription by RNA polymerase II, response to UV-B, response to amino acid, response to bacterium, response to cAMP, response to cobalamin, response to cytokine, response to ethanol, response to hydrogen peroxide, response to insulin, response to interleukin-1, response to ischemia, response to lipopolysaccharide, response to mechanical stimulus, response to morphine, response to muramyl dipeptide, response to muscle stretch, response to progesterone, response to xenobiotic stimulus, signal transduction involved in regulation of gene expression, toll-like receptor 4 signaling pathway, toll-like receptor TLR6:TLR2 signaling pathway, tumor necrosis factor-mediated signaling pathway, vascular endothelial growth factor signaling pathway; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, NF-kappaB binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, actinin binding, ankyrin repeat binding, chromatin DNA binding, chromatin binding, double-stranded DNA binding, enzyme binding, general transcription initiation factor binding, histone deacetylase binding, identical protein binding, peptide binding, phosphate ion binding, protein binding, protein homodimerization activity, protein kinase binding, protein-containing complex binding, sequence-specific DNA binding, transcription cis-regulatory region binding, transcription coactivator binding, ubiquitin protein ligase binding; CC: NF-kappaB complex, NF-kappaB p50/p65 complex, chromatin, cytoplasm, cytosol, glutamatergic synapse, nucleolus, nucleoplasm, nucleus, protein-containing complex, synapse, transcription regulator complex
Pathways: AGE-RAGE pathway, AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Activation of NLRP3 Inflammasome by SARS-CoV-2, Acute myeloid leukemia - Homo sapiens (human), Adipocytokine signaling pathway - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Amoebiasis - Homo sapiens (human), Androgen receptor signaling pathway, Angiopoietin receptor Tie2-mediated signaling, ApoE and miR-146 in inflammation and atherosclerosis, Apoptosis, Apoptosis - Homo sapiens (human), Aryl Hydrocarbon Receptor Netpath, Atypical NF-kappaB pathway, B Cell Receptor Signaling Pathway, B cell receptor signaling pathway - Homo sapiens (human), BCR, BCR signaling pathway, BDNF, Brain-derived neurotrophic factor (BDNF) signaling pathway, C-type lectin receptor signaling pathway - Homo sapiens (human), CAMKK2 Pathway, CD40/CD40L signaling, CRH, Canonical NF-KB pathway, Canonical NF-kappaB pathway, Cellular senescence - Homo sapiens (human), Ceramide signaling pathway, Chagas disease - Homo sapiens (human), Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Chronic myeloid leukemia - Homo sapiens (human), Cocaine addiction - Homo sapiens (human), Coronavirus disease - COVID-19 - Homo sapiens (human), Corticotropin-releasing hormone signaling pathway, Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Diabetic cardiomyopathy - Homo sapiens (human), EGFR1, Ebola Virus Pathway on Host, Ebstein-Barr virus LMP1 signaling, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), Fc-epsilon receptor I signaling in mast cells, Fluid shear stress and atherosclerosis - Homo sapiens (human), Folate Metabolism, Gastrin, Gastrin signaling pathway, Ghrelin, Glucocorticoid receptor regulatory network, HIF-1 signaling pathway - Homo sapiens (human), HIV-1 Nef: Negative effector of Fas and TNF-alpha, Head and Neck Squamous Cell Carcinoma, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IL-1 signaling pathway, IL-17 signaling pathway - Homo sapiens (human), IL-18 signaling pathway, IL-4 signaling pathway, IL1, IL1-mediated signaling events, IL11, IL12-mediated signaling events, IL17 signaling pathway, IL2, IL2 signaling events mediated by PI3K, IL23-mediated signaling events, Inflammatory bowel disease - Homo sapiens (human), Influenza A - Homo sapiens (human), Initiation of transcription and translation elongation at the HIV-1 LTR, Insulin resistance - Homo sapiens (human), Interleukin-11 Signaling Pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), KitReceptor, LPA receptor mediated events, Legionellosis - Homo sapiens (human), Leishmaniasis - Homo sapiens (human), Leptin signaling pathway, Lipid and atherosclerosis - Homo sapiens (human), Longevity regulating pathway - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Measles - Homo sapiens (human), Mitophagy - animal - Homo sapiens (human), Modulators of TCR signaling and T cell activation, NF-kappa B signaling pathway - Homo sapiens (human), NLR Proteins, NO-cGMP-PKG mediated Neuroprotection, NOD-like receptor signaling pathway - Homo sapiens (human), Neuroinflammation, Neurotrophin signaling pathway - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Notch, Novel intracellular components of RIG-I-like receptor (RLR) pathway, Nucleotide-binding Oligomerization Domain (NOD) pathway, Oncostatin M Signaling Pathway, Oncostatin_M, Osteoclast differentiation - Homo sapiens (human), Osteopontin Signaling, Osteopontin-mediated events, PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), PI3K-AKT-mTOR - VitD3 signaling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Pertussis - Homo sapiens (human), Photodynamic therapy-induced NF-kB survival signaling, Prolactin, Prolactin Signaling Pathway, Prolactin signaling pathway - Homo sapiens (human), Prostate cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, RAGE, RANKL-RANK signaling pathway, RIG-I-like receptor signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of toll-like receptor signaling pathway, Relaxin signaling pathway - Homo sapiens (human), Resistin as a regulator of inflammation, Role of Altered Glycolysation of MUC1 in Tumour Microenvironment, STING pathway in Kawasaki-like disease and COVID-19, Salmonella infection - Homo sapiens (human), Selenium Micronutrient Network, Shigellosis - Homo sapiens (human), Signal transduction through IL1R, Signaling events mediated by HDAC Class I, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Sphingolipid signaling pathway - Homo sapiens (human), Structural Pathway of Interleukin 1 (IL-1), Supression of HMGB1 mediated inflammation by THBD, T cell receptor signaling pathway - Homo sapiens (human), T-cell receptor (TCR) signaling pathway, TCR, TNF receptor signaling pathway , TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, TNF signaling pathway - Homo sapiens (human), TNFalpha, TSLP, TWEAK, Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, Toll-like Receptor Signaling Pathway, Toll-like Receptor Signaling related to MyD88, Toll-like receptor signaling pathway - Homo sapiens (human), Toxoplasmosis - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), Tuberculosis - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, Viral carcinogenesis - Homo sapiens (human), Vitamin B12 metabolism, Vitamin D in inflammatory diseases, Yersinia infection - Homo sapiens (human), acetylation and deacetylation of rela in nucleus, akt signaling pathway, atm signaling pathway, bone remodeling, cAMP signaling pathway - Homo sapiens (human), cadmium induces dna synthesis and proliferation in macrophages, cd40l signaling pathway, ceramide signaling pathway, chaperones modulate interferon signaling pathway, corticosteroids and cardioprotection, double stranded rna induced gene expression, erythropoietin mediated neuroprotection through nf-kb, fmlp induced chemokine gene expression in hmc-1 cells, hiv-1 nef: negative effector of fas and tnf, human cytomegalovirus and map kinase pathways, inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages, influence of ras and rho proteins on g1 to s transition, keratinocyte differentiation, mechanism of gene regulation by peroxisome proliferators via ppara, miRNAs involvement in the immune response in sepsis, ncRNAs involved in STAT3 signaling in hepatocellular carcinoma, nf-kb signaling pathway, nfkb activation by nontypeable hemophilus influenzae, p73 transcription factor network, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, signal transduction through il1r, t cell receptor signaling pathway, the 41bb-dependent immune response, the information processing pathway at the ifn beta enhancer, tnfr2 signaling pathway, toll-like receptor pathway, trefoil factors initiate mucosal healing
UniProt: Q04206
Entrez ID: 5970
|
Does Knockout of MYH9 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
MYH9
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MYH9 (myosin heavy chain 9)
Type: protein-coding
Summary: This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: actin cytoskeleton organization, actin filament-based movement, actomyosin structure organization, angiogenesis, blood vessel endothelial cell migration, cell adhesion, cell morphogenesis, cell motility, cell-cell adhesion, cortical granule exocytosis, cytokinetic process, cytoplasmic actin-based contraction involved in cell motility, cytoskeleton organization, endodermal cell differentiation, establishment of T cell polarity, establishment of meiotic spindle localization, in utero embryonic development, integrin-mediated signaling pathway, leukocyte migration, lysosome localization, meiotic spindle organization, membrane protein ectodomain proteolysis, monocyte differentiation, myoblast fusion, negative regulation of actin filament severing, phagocytosis, engulfment, plasma membrane repair, platelet aggregation, platelet formation, positive regulation of protein processing in phagocytic vesicle, protein transport, regulated exocytosis, regulation of actin filament-based process, regulation of cell shape, regulation of plasma membrane repair, symbiont entry into host cell, uropod organization; MF: ADP binding, ATP binding, RNA binding, actin binding, actin filament binding, cadherin binding, calmodulin binding, cytoskeletal motor activity, identical protein binding, integrin binding, microfilament motor activity, nucleotide binding, protein binding, protein domain specific binding, protein homodimerization activity, protein-membrane adaptor activity, virus receptor activity; CC: COP9 signalosome, Golgi apparatus, actin cytoskeleton, actomyosin, actomyosin contractile ring, adherens junction, brush border, cell cortex, cell leading edge, cell surface, cleavage furrow, cortical cytoskeleton, cortical granule, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, cytosol, extracellular exosome, focal adhesion, immunological synapse, membrane, myosin II complex, myosin II filament, myosin complex, myosin filament, neuromuscular junction, nuclear body, nucleus, plasma membrane, protein-containing complex, ruffle, spindle, stress fiber, supramolecular fiber, uropod
Pathways: Anti-inflammatory response favouring Leishmania parasite infection, Axon guidance, CD163 mediating an anti-inflammatory response, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, EGFR1, EPH-Ephrin signaling, EPHA-mediated growth cone collapse, FCGR3A-mediated phagocytosis, Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania parasite growth and survival, Leishmania phagocytosis, Membrane Trafficking, Nephrotic syndrome, Nervous system development, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), Primary focal segmental glomerulosclerosis (FSGS), RHO GTPase Effectors, RHO GTPases Activate ROCKs, RHO GTPases activate CIT, RHO GTPases activate PAKs, RHO GTPases activate PKNs, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Semaphorin interactions, Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea, Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, VEGFA-VEGFR2 Signaling Pathway, Vascular smooth muscle contraction - Homo sapiens (human), Vesicle-mediated transport
UniProt: P35579
Entrez ID: 4627
|
Does Knockout of DDX42 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
DDX42
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: DDX42 (DEAD-box helicase 42)
Type: protein-coding
Summary: This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: U2-type prespliceosome assembly, intracellular protein localization, regulation of apoptotic process; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: Cajal body, U2-type prespliceosome, cytoplasm, cytosol, membrane, nuclear speck, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q86XP3
Entrez ID: 11325
|
Does Knockout of INHBA in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
INHBA
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: INHBA (inhibin subunit beta A)
Type: protein-coding
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: GABAergic neuron differentiation, SMAD protein signal transduction, Sertoli cell differentiation, activin receptor signaling pathway, androgen metabolic process, androst-4-ene-3,17-dione biosynthetic process, animal organ development, autophagy, cardiac fibroblast cell development, cell development, cell differentiation, cell surface receptor protein serine/threonine kinase signaling pathway, cell surface receptor signaling pathway, cell-cell signaling, cellular response to angiotensin, cellular response to cholesterol, cellular response to follicle-stimulating hormone stimulus, cellular response to hypoxia, cellular response to oxygen-glucose deprivation, cytokine-mediated signaling pathway, defense response, endodermal cell differentiation, erythrocyte differentiation, extrinsic apoptotic signaling pathway, eyelid development in camera-type eye, gene expression, hair follicle development, hematopoietic progenitor cell differentiation, hemoglobin biosynthetic process, lipid metabolic process, male gonad development, mesoderm formation, mesodermal cell differentiation, negative regulation of B cell differentiation, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of follicle-stimulating hormone secretion, negative regulation of macrophage differentiation, negative regulation of phosphorylation, negative regulation of type II interferon production, nervous system development, odontogenesis, ovarian follicle development, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of SMAD protein signal transduction, positive regulation of collagen biosynthetic process, positive regulation of erythrocyte differentiation, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of follicle-stimulating hormone secretion, positive regulation of gene expression, positive regulation of ovulation, positive regulation of protein metabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, progesterone secretion, regulation of follicle-stimulating hormone secretion, regulation of transcription by RNA polymerase II, response to aldosterone, response to wounding, roof of mouth development, steroid biosynthetic process, steroid metabolic process, striatal medium spiny neuron differentiation, system development, testosterone biosynthetic process, transcription by RNA polymerase II; MF: cytokine activity, growth factor activity, hormone activity, identical protein binding, peptide hormone binding, protein binding, protein-containing complex binding, signaling receptor binding, type II activin receptor binding; CC: activin A complex, enzyme activator complex, extracellular region, extracellular space, inhibin A complex, perinuclear region of cytoplasm
Pathways: ALK1 signaling events, Antagonism of Activin by Follistatin, Cardiac Progenitor Differentiation, Cytokine-cytokine receptor interaction - Homo sapiens (human), Differentiation Pathway, Glycoprotein hormones, Mesodermal commitment pathway, Metabolism of proteins, Peptide hormone biosynthesis, Peptide hormone metabolism, Senescence and Autophagy in Cancer, Signal Transduction, Signaling by Activin, Signaling by BMP, Signaling by TGFB family members, Signaling by TGFBR3, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), TGF-beta Receptor Signaling, TGF-beta receptor signaling in skeletal dysplasias, TGF-beta signaling pathway - Homo sapiens (human), TGFBR3 regulates activin signaling
UniProt: P08476
Entrez ID: 3624
|
Does Knockout of MIR4442 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
MIR4442
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: MIR4442 (microRNA 4442)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100616477
|
Does Knockout of RBBP5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
RBBP5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit)
Type: protein-coding
Summary: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: DNA damage response, chromatin organization, response to estrogen, transcription initiation-coupled chromatin remodeling; MF: histone binding, protein binding, transcription cis-regulatory region binding; CC: MLL1 complex, MLL1/2 complex, MLL3/4 complex, Set1C/COMPASS complex, histone methyltransferase complex, nucleolus, nucleoplasm, nucleus
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Adaptive Immune System, Chromatin modifying enzymes, Chromatin organization, Co-inhibition by PD-1, Cushing syndrome - Homo sapiens (human), Deactivation of the beta-catenin transactivating complex, Developmental Biology, Disease, Disorders of Developmental Biology, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Formation of WDR5-containing histone-modifying complexes, Formation of the beta-catenin:TCF transactivating complex, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Loss of Function of KMT2D in Kabuki Syndrome, Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism of proteins, Neddylation, PKMTs methylate histone lysines, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Transcriptional regulation by RUNX1
UniProt: Q15291
Entrez ID: 5929
|
Does Knockout of LSM5 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
LSM5
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: LSM5 (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: RNA splicing, mRNA catabolic process, mRNA processing, mRNA splicing, via spliceosome, response to bacterium; MF: RNA binding, protein binding, protein heterodimerization activity; CC: Lsm1-7-Pat1 complex, Lsm2-8 complex, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, cytosol, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Homo sapiens (human), Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q9Y4Y9
Entrez ID: 23658
|
Does Knockout of PHF1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
PHF1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: PHF1 (PHD finger protein 1)
Type: protein-coding
Summary: This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Gene Ontology: BP: DNA damage response, DNA repair-dependent chromatin remodeling, chromatin organization, negative regulation of gene expression, epigenetic; MF: DNA binding, chromatin binding, histone H3K36me3 reader activity, histone H3K4me3 reader activity, histone methyltransferase binding, identical protein binding, metal ion binding, protein binding, transcription corepressor binding, zinc ion binding; CC: ESC/E(Z) complex, centrosome, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, site of double-strand break
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), PRC2 methylates histones and DNA
UniProt: O43189
Entrez ID: 5252
|
Does Knockout of ETFRF1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
ETFRF1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: ETFRF1 (electron transfer flavoprotein regulatory factor 1)
Type: protein-coding
Summary: Involved in respiratory electron transport chain. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of cellular respiration, negative regulation of oxidative phosphorylation; MF: enzyme inhibitor activity, protein binding; CC: mitochondrion
Pathways:
UniProt: Q6IPR1
Entrez ID: 144363
|
Does Knockout of MOBP in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
MOBP
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: MOBP (myelin associated oligodendrocyte basic protein)
Type: protein-coding
Summary: Predicted to enable actin binding activity and myosin binding activity. Predicted to be a structural constituent of myelin sheath. Predicted to be involved in nervous system development. Predicted to be located in mitochondrion. Predicted to be active in cortical actin cytoskeleton. Implicated in frontotemporal dementia. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, structural constituent of myelin sheath; CC: cytoplasm, mitochondrion, perinuclear region of cytoplasm
Pathways:
UniProt: Q13875
Entrez ID: 4336
|
Does Knockout of PPAT in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
PPAT
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: PPAT (phosphoribosyl pyrophosphate amidotransferase)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011].
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, purine nucleobase biosynthetic process, purine nucleotide biosynthetic process; MF: 4 iron, 4 sulfur cluster binding, amidophosphoribosyltransferase activity, catalytic activity, glycosyltransferase activity, iron-sulfur cluster binding, metal ion binding, protein binding, transferase activity
Pathways: 2-Hydroxyglutric Aciduria (D And L Form), 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency, 5-aminoimidazole ribonucleotide biosynthesis, AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Alanine, aspartate and glutamate metabolism - Homo sapiens (human), Azathioprine Action Pathway, Fluoropyrimidine Activity, Glutamate Metabolism, Gout or Kelley-Seegmiller Syndrome, Homocarnosinosis, Hyperinsulinism-Hyperammonemia Syndrome, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Mercaptopurine Metabolism Pathway, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide biosynthesis, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Purine ribonucleoside monophosphate biosynthesis, Succinic semialdehyde dehydrogenase deficiency, Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, purine nucleotides <i>de novo</i> biosynthesis
UniProt: Q06203
Entrez ID: 5471
|
Does Knockout of RRN3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
RRN3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RRN3 (RNA polymerase I transcription factor RRN3)
Type: protein-coding
Summary: Enables RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation from RNA polymerase I promoter. Predicted to act upstream of or within several processes, including DNA-templated transcription, initiation; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of transcription, DNA-templated. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase I preinitiation complex assembly, cytoplasm organization, fibroblast proliferation, homeostasis of number of cells, in utero embryonic development, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, nucleolus organization, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription initiation, ribosome biogenesis, transcription initiation at RNA polymerase I promoter; MF: RNA polymerase I core binding, RNA polymerase I core promoter sequence-specific DNA binding, RNA polymerase I general transcription initiation factor activity, RNA polymerase binding, protein binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, mTOR signaling pathway
UniProt: Q9NYV6
Entrez ID: 54700
|
Does Knockout of TRIM10 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
TRIM10
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: TRIM10 (tripartite motif containing 10)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: erythrocyte differentiation, host-mediated suppression of symbiont invasion, innate immune response; MF: metal ion binding, protein binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm
Pathways:
UniProt: Q9UDY6
Entrez ID: 10107
|
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