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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of EFR3B in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
EFR3B
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: EFR3B (EFR3 homolog B)
Type: protein-coding
Summary: Involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Located in actin cytoskeleton; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: phosphatidylinositol phosphate biosynthetic process, protein localization to plasma membrane, social behavior, transmission of nerve impulse; CC: actin cytoskeleton, cytoplasm, cytosol, membrane, plasma membrane
Pathways:
UniProt: Q9Y2G0
Entrez ID: 22979
|
Does Knockout of GOLT1A in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
GOLT1A
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: GOLT1A (golgi transport 1A)
Type: protein-coding
Summary: Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus subcompartment; endoplasmic reticulum; and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated transport; CC: Golgi apparatus, Golgi cis cisterna, Golgi membrane, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum, membrane, nuclear envelope, trans-Golgi network
Pathways:
UniProt: Q6ZVE7
Entrez ID: 127845
|
Does Knockout of CST11 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
CST11
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CST11 (cystatin 11)
Type: protein-coding
Summary: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: androgen receptor signaling pathway, defense response to Gram-negative bacterium, defense response to bacterium, killing of cells of another organism; MF: cysteine-type endopeptidase inhibitor activity, peptidase inhibitor activity; CC: cytoplasm, extracellular region, nucleus, sperm flagellum, sperm head
Pathways:
UniProt: Q9H112
Entrez ID: 140880
|
Does Knockout of PRKRA in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
PRKRA
|
cell proliferation
|
Bladder Carcinoma
|
Gene: PRKRA (protein activator of interferon induced protein kinase EIF2AK2)
Type: protein-coding
Summary: This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].
Gene Ontology: BP: RISC complex assembly, antiviral innate immune response, cellular response to oxidative stress, ear development, immune response, miRNA processing, middle ear morphogenesis, negative regulation of cell population proliferation, outer ear morphogenesis, positive regulation of intrinsic apoptotic signaling pathway, pre-miRNA processing, protein stabilization, regulation of regulatory ncRNA processing, regulatory ncRNA-mediated gene silencing, response to virus, siRNA processing, skeletal system morphogenesis; MF: RNA binding, double-stranded RNA binding, enzyme activator activity, enzyme binding, identical protein binding, pre-miRNA binding, protein binding, protein homodimerization activity, protein kinase activator activity, siRNA binding; CC: RISC complex, RISC-loading complex, cytoplasm, cytosol, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Ceramide signaling pathway, Ebola Virus Pathway on Host, VEGFA-VEGFR2 Signaling Pathway
UniProt: O75569
Entrez ID: 8575
|
Does Knockout of DEFB104B in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
DEFB104B
|
cell proliferation
|
Cancer Cell Line
|
Gene: DEFB104B (defensin beta 104B)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104B, represents the more telomeric copy. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: cellular response to phorbol 13-acetate 12-myristate, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, innate immune response, monocyte chemotaxis, positive chemotaxis
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q8WTQ1
Entrez ID: 503618
|
Does Knockout of C3orf62 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
C3orf62
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: C3orf62 (chromosome 3 open reading frame 62)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, spermatogenesis
Pathways:
UniProt: Q6ZUJ4
Entrez ID: 375341
|
Does Knockout of CDK14 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
CDK14
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CDK14 (cyclin dependent kinase 14)
Type: protein-coding
Summary: PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
Gene Ontology: BP: G2/M transition of mitotic cell cycle, Wnt signaling pathway, cell division, regulation of canonical Wnt signaling pathway, regulation of cell cycle phase transition; MF: ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytoplasmic cyclin-dependent protein kinase holoenzyme complex, cytosol, membrane, nucleoplasm, nucleus, plasma membrane
Pathways: Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: O94921
Entrez ID: 5218
|
Does Knockout of PSMB6 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
PSMB6
|
cell proliferation
|
Melanoma Cell Line
|
Gene: PSMB6 (proteasome 20S subunit beta 6)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: cadherin binding, endopeptidase activity, hydrolase activity, peptidase activity, protein binding, threonine-type endopeptidase activity; CC: cytoplasm, cytosol, extracellular exosome, mitochondrion, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, antigen processing and presentation, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: P28072
Entrez ID: 5694
|
Does Knockout of WDR73 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
WDR73
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: WDR73 (WD repeat domain 73)
Type: protein-coding
Summary: The protein encoded by this gene is thought to contain multiple WD40 repeats. WD40 repeats are motifs that contain 40-60 amino acids, and usually end with Trp-Asp (WD). This protein is found in the cytoplasm during interphase, but accumulates at the spindle poles and astral microtubules during mitosis. Reduced expression of this gene results in abnormalities in the size and morphology of the nucleus. Mutations in this gene have been associated with Galloway-Mowat syndrome PMID: 25466283), which is a rare autosomal recessive disorder that affects both the central nervous system and kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: cytoplasmic microtubule organization, nucleus organization; MF: protein binding, protein-macromolecule adaptor activity; CC: cleavage furrow, cytoplasm, cytoskeleton, cytosol, spindle, spindle pole
Pathways: Nephrotic syndrome
UniProt: Q6P4I2
Entrez ID: 84942
|
Does Knockout of ALG11 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
ALG11
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ALG11 (ALG11 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation; MF: GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity, alpha-1,2-mannosyltransferase activity, glycosyltransferase activity, protein binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective ALG11 causes CDG-1p, Disease, Diseases associated with N-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), Post-translational protein modification, Various types of N-glycan biosynthesis - Homo sapiens (human)
UniProt: Q2TAA5
Entrez ID: 440138
|
Does Knockout of LRRC73 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
LRRC73
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: LRRC73 (leucine rich repeat containing 73)
Type: protein-coding
Summary: leucine rich repeat containing 73
Gene Ontology:
Pathways:
UniProt: Q5JTD7
Entrez ID: 221424
|
Does Knockout of BMP10 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
BMP10
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: BMP10 (bone morphogenetic protein 10)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: BMP signaling pathway, activin receptor signaling pathway, adult heart development, atrial cardiac muscle tissue morphogenesis, cardiac muscle cell proliferation, cell adhesion, heart development, heart trabecula formation, kidney development, negative regulation of cardiac muscle hypertrophy, negative regulation of cell growth, negative regulation of cell migration, negative regulation of endothelial cell migration, positive regulation of DNA-templated transcription, positive regulation of SMAD protein signal transduction, positive regulation of cardiac muscle cell proliferation, positive regulation of cardiac muscle hypertrophy, positive regulation of cartilage development, positive regulation of cell proliferation involved in heart morphogenesis, positive regulation of gene expression, positive regulation of multicellular organismal process, positive regulation of sarcomere organization, regulation of cardiac muscle contraction, regulation of cardiac muscle hypertrophy, regulation of cardiac muscle hypertrophy in response to stress, regulation of transmembrane receptor protein serine/threonine kinase signaling pathway, sarcomere organization, ventricular cardiac muscle cell development, ventricular cardiac muscle tissue morphogenesis; MF: cytokine activity, growth factor activity, hormone activity, protein binding, receptor serine/threonine kinase binding, telethonin binding; CC: Z disc, cell surface, cytoplasm, extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human), Elastic fibre formation, Extracellular matrix organization, Heart Development, Molecules associated with elastic fibres, Signal Transduction, Signaling by BMP, Signaling by TGFB family members, VEGFA-VEGFR2 Signaling Pathway, alk in cardiac myocytes
UniProt: O95393
Entrez ID: 27302
|
Does Knockout of ZNF322 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
ZNF322
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ZNF322 (zinc finger protein 322)
Type: protein-coding
Summary: ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: positive regulation of stem cell population maintenance, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: centrosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q6U7Q0
Entrez ID: 79692
|
Does Knockout of B9D1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
B9D1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: B9D1 (B9 domain containing 1)
Type: protein-coding
Summary: This gene encodes a B9 domain-containing protein, one of several that are involved in ciliogenesis. Alterations in expression of this gene have been found in a family with Meckel syndrome. Meckel syndrome has been associated with at least six different genes. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: camera-type eye development, cell projection organization, cilium assembly, embryonic digit morphogenesis, in utero embryonic development, neuroepithelial cell differentiation, regulation of protein localization, smoothened signaling pathway, vasculature development; MF: hedgehog receptor activity, protein binding; CC: MKS complex, cell projection, centrosome, ciliary basal body, ciliary transition zone, cilium, cytoplasm, cytoskeleton, cytosol, membrane
Pathways: Anchoring of the basal body to the plasma membrane, Ciliopathies, Cilium Assembly, Genes related to primary cilium development (based on CRISPR), Joubert Syndrome, Organelle biogenesis and maintenance
UniProt: Q9UPM9
Entrez ID: 27077
|
Does Knockout of WDTC1 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
WDTC1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: WDTC1 (WD and tetratricopeptide repeats 1)
Type: protein-coding
Summary: Predicted to enable enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to act upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to insulin stimulus, glucose metabolic process, in utero embryonic development, intracellular chemical homeostasis, multicellular organism growth, negative regulation of fatty acid biosynthetic process, negative regulation of transcription by RNA polymerase II, protein ubiquitination, regulation of cell size; MF: enzyme inhibitor activity, histone binding, histone deacetylase binding, protein binding; CC: Cul4-RING E3 ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q8N5D0
Entrez ID: 23038
|
Does Knockout of UGT2A1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
UGT2A1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: UGT2A1 (UDP glucuronosyltransferase family 2 member A1 complex locus)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 infection. [provided by RefSeq, Jan 2022].
Gene Ontology: BP: bile acid metabolic process, lipid metabolic process, response to symbiont, sensory perception of chemical stimulus, sensory perception of smell, xenobiotic metabolic process; MF: UDP-glycosyltransferase activity, glucuronosyltransferase activity, glycosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Ascorbate and aldarate metabolism - Homo sapiens (human), Aspirin ADME, Bile secretion - Homo sapiens (human), Biological oxidations, Chemical carcinogenesis - Homo sapiens (human), Drug ADME, Drug metabolism - cytochrome P450 - Homo sapiens (human), Drug metabolism - other enzymes - Homo sapiens (human), Glucuronidation, Metabolism, Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human), Metapathway biotransformation Phase I and II, Pentose and glucuronate interconversions - Homo sapiens (human), Phase II - Conjugation of compounds, Porphyrin and chlorophyll metabolism - Homo sapiens (human), Retinol metabolism - Homo sapiens (human), Steroid hormone biosynthesis - Homo sapiens (human)
UniProt: P0DTE4
Entrez ID: 10941
|
Does Knockout of OST4 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
OST4
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: OST4 (oligosaccharyltransferase complex subunit 4, non-catalytic)
Type: protein-coding
Summary: Involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Asparagine N-linked glycosylation, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Disease, Immune System, Infectious disease, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Viral Infection Pathways
UniProt: P0C6T2
Entrez ID: 100128731
|
Does Knockout of RCC1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
RCC1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: RCC1 (regulator of chromosome condensation 1)
Type: protein-coding
Summary: Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in several processes, including G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Located in chromatin; cytoplasm; and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, chromosome segregation, mitotic nuclear membrane reassembly, mitotic spindle organization, regulation of mitotic cell cycle, regulation of mitotic nuclear division, regulation of mitotic spindle assembly, spindle assembly, viral process; MF: DNA binding, chromatin binding, guanyl-nucleotide exchange factor activity, histone binding, nucleosomal DNA binding, nucleosome binding, protein binding, protein heterodimerization activity, small GTPase binding, sulfate binding; CC: chromatin, chromosome, condensed nuclear chromosome, cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways: 22q11.2 copy number variation syndrome, Cell Cycle, Cell Cycle, Mitotic, Disease, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, Infectious disease, Interactions of Rev with host cellular proteins, Late Phase of HIV Life Cycle, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Nuclear Envelope (NE) Reassembly, Nuclear import of Rev protein, Postmitotic nuclear pore complex (NPC) reformation, Rev-mediated nuclear export of HIV RNA, Validated targets of C-MYC transcriptional activation, Viral Infection Pathways, cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, role of ran in mitotic spindle regulation
UniProt: P18754
Entrez ID: 1104
|
Does Knockout of C14orf93 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
C14orf93
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: C14orf93 (chromosome 14 open reading frame 93)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to act upstream of or within anatomical structure development; cell differentiation; and positive regulation of gene expression. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, positive regulation of gene expression; MF: RNA binding, protein binding
Pathways:
UniProt: Q9H972
Entrez ID: 60686
|
Does Knockout of FAM185A in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
FAM185A
|
cell proliferation
|
Cancer Cell Line
|
Gene: FAM185A (family with sequence similarity 185 member A)
Type: protein-coding
Summary: Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q8N0U4
Entrez ID: 222234
|
Does Knockout of RPRD2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
RPRD2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RPRD2 (regulation of nuclear pre-mRNA domain containing 2)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA polymerase II C-terminal domain binding, RNA polymerase II complex binding; CC: nucleoplasm, transcription preinitiation complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q5VT52
Entrez ID: 23248
|
Does Knockout of RANBP3 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
RANBP3
|
cell proliferation
|
Cancer Cell Line
|
Gene: RANBP3 (RAN binding protein 3)
Type: protein-coding
Summary: This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: protein export from nucleus, protein transport; MF: R-SMAD binding, protein binding, small GTPase binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Canonical Wnt signaling pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human)
UniProt: Q9H6Z4
Entrez ID: 8498
|
Does Knockout of LONP1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
LONP1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: LONP1 (lon peptidase 1, mitochondrial)
Type: protein-coding
Summary: This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: cellular response to oxidative stress, chaperone-mediated protein complex assembly, mitochondrial DNA metabolic process, mitochondrial protein catabolic process, mitochondrion organization, negative regulation of insulin receptor signaling pathway, oxidation-dependent protein catabolic process, protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins, protein-containing complex assembly, proteolysis, proteolysis involved in protein catabolic process, response to aluminum ion, response to hormone, response to hypoxia; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, DNA binding, DNA polymerase binding, G-quadruplex DNA binding, PH domain binding, hydrolase activity, identical protein binding, insulin receptor substrate binding, mitochondrial promoter sequence-specific DNA binding, nucleotide binding, peptidase activity, protein binding, sequence-specific DNA binding, serine-type endopeptidase activity, serine-type peptidase activity, single-stranded DNA binding, single-stranded RNA binding; CC: cytosol, membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleoplasm
Pathways: Cellular responses to stimuli, Cellular responses to stress, Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial unfolded protein response (UPRmt)
UniProt: P36776
Entrez ID: 9361
|
Does Knockout of TEX36 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
TEX36
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: TEX36 (testis expressed 36)
Type: protein-coding
Summary: testis expressed 36
Gene Ontology:
Pathways:
UniProt: Q5VZQ5
Entrez ID: 387718
|
Does Knockout of CAVIN1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
CAVIN1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: CAVIN1 (caveolae associated protein 1)
Type: protein-coding
Summary: This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009].
Gene Ontology: BP: DNA-templated transcription termination, positive regulation of cell motility, protein secretion, rRNA transcription, termination of RNA polymerase I transcription, transcription initiation at RNA polymerase I promoter; MF: RNA binding, identical protein binding, protein binding, rRNA binding, rRNA primary transcript binding; CC: caveola, cytoplasm, cytosol, endoplasmic reticulum, membrane, membrane raft, mitochondrion, nucleoplasm, nucleus, plasma membrane, protein-containing complex
Pathways: EGFR1, Gene expression (Transcription), RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RNA Polymerase I Transcription, RNA Polymerase I Transcription Termination, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6NZI2
Entrez ID: 284119
|
Does Knockout of STMN3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
STMN3
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: STMN3 (stathmin 3)
Type: protein-coding
Summary: This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: blastocyst hatching, cytoplasmic microtubule organization, microtubule depolymerization, negative regulation of Rac protein signal transduction, negative regulation of neuron projection development, nervous system development, neuron projection development, regulation of cytoskeleton organization, regulation of microtubule polymerization or depolymerization; MF: protein binding, protein domain specific binding, tubulin binding; CC: Golgi apparatus, axon, cell projection, cytoplasm, cytosol, growth cone, neuron projection
Pathways:
UniProt: Q9NZ72
Entrez ID: 50861
|
Does Knockout of HFE in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
HFE
|
response to chemicals
|
Melanoma Cell Line
|
Gene: HFE (homeostatic iron regulator)
Type: protein-coding
Summary: The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. [provided by RefSeq, May 2022].
Gene Ontology: BP: BMP signaling pathway, antigen processing and presentation, antigen processing and presentation of peptide antigen via MHC class I, cell surface receptor signaling pathway, cellular response to iron ion, hormone biosynthetic process, intracellular iron ion homeostasis, iron ion transport, monoatomic ion transport, multicellular organismal-level iron ion homeostasis, negative regulation of CD8-positive, alpha-beta T cell activation, negative regulation of T cell cytokine production, negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of SMAD protein signal transduction, positive regulation of gene expression, positive regulation of peptide hormone secretion, positive regulation of receptor-mediated endocytosis, protein-containing complex assembly, receptor-mediated endocytosis, regulation of T cell mediated immunity, regulation of iron ion transport, regulation of protein localization to cell surface, response to iron ion, response to iron ion starvation, transferrin transport; MF: beta-2-microglobulin binding, co-receptor binding, peptide antigen binding, protein binding, signaling receptor binding, transferrin receptor binding, transporter activator activity; CC: HFE-transferrin receptor complex, MHC class I protein complex, apical part of cell, basal part of cell, cytoplasmic vesicle, early endosome, external side of plasma membrane, extracellular space, membrane, nucleoplasm, perinuclear region of cytoplasm, plasma membrane, recycling endosome
Pathways: 3q29 copy number variation syndrome, Hfe effect on hepcidin production, Iron uptake and transport, Transferrin endocytosis and recycling, Transport of small molecules
UniProt: Q30201
Entrez ID: 3077
|
Does Knockout of PGM2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
PGM2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: PGM2 (phosphoglucomutase 2)
Type: protein-coding
Summary: Enables phosphopentomutase activity. Predicted to be involved in carbohydrate metabolic process and deoxyribose phosphate catabolic process. Predicted to act upstream of or within glucose metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: carbohydrate metabolic process, glucose metabolic process, glycogen biosynthetic process, glycogen catabolic process, purine ribonucleoside salvage; MF: catalytic activity, intramolecular phosphotransferase activity, isomerase activity, magnesium ion binding, metal ion binding, phosphoglucomutase activity, phosphopentomutase activity, protein binding; CC: cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, secretory granule lumen
Pathways: 2,-deoxy-α-D-ribose 1-phosphate degradation, Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), D-galactose degradation V (Leloir pathway), GDP-glucose biosynthesis II, Galactose metabolism - Homo sapiens (human), Glucuronidation, Glycolysis / Gluconeogenesis - Homo sapiens (human), Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Pathways in clear cell renal cell carcinoma, Pentose phosphate pathway, Pentose phosphate pathway - Homo sapiens (human), Purine metabolism - Homo sapiens (human), Starch and sucrose metabolism - Homo sapiens (human), glycogen biosynthesis, glycogenolysis, purine ribonucleosides degradation to ribose-1-phosphate
UniProt: Q96G03
Entrez ID: 55276
|
Does Knockout of PXDN in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
PXDN
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: PXDN (peroxidasin)
Type: protein-coding
Summary: This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: angiogenesis, basement membrane assembly, basement membrane organization, cell adhesion, cellular oxidant detoxification, collagen fibril organization, extracellular matrix organization, eye development, hydrogen peroxide catabolic process, immune response, negative regulation of cytokine-mediated signaling pathway, protein homooligomerization, protein homotrimerization, response to oxidative stress, system development; MF: extracellular matrix structural constituent, heme binding, interleukin-1 receptor antagonist activity, lactoperoxidase activity, laminin-1 binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on peroxide as acceptor, peroxidase activity; CC: basement membrane, cell surface, endoplasmic reticulum, extracellular exosome, extracellular matrix, extracellular region, extracellular space
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, Developmental Biology, EGF-EGFR signaling pathway, Extracellular matrix organization, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
UniProt: Q92626
Entrez ID: 7837
|
Does Knockout of MATR3 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
MATR3
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: MATR3 (matrin 3)
Type: protein-coding
Summary: This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: activation of innate immune response, blastocyst formation, heart valve development, immune system process, innate immune response, post-transcriptional regulation of gene expression, ventricular septum development; MF: RNA binding, identical protein binding, metal ion binding, miRNA binding, nucleic acid binding, protein binding, structural molecule activity, zinc ion binding; CC: membrane, nuclear inner membrane, nuclear matrix, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), antisense pathway
UniProt: P43243
Entrez ID: 9782
|
Does Knockout of NLRC3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
NLRC3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: NLRC3 (NLR family CARD domain containing 3)
Type: protein-coding
Summary: This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: T cell activation, canonical NF-kappaB signal transduction, negative regulation of NF-kappaB transcription factor activity, negative regulation of NLRP3 inflammasome complex assembly, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cytokine production involved in inflammatory response, negative regulation of epithelial cell proliferation, negative regulation of fibroblast proliferation, negative regulation of immune system process, negative regulation of inflammatory response, negative regulation of innate immune response, negative regulation of interferon-alpha production, negative regulation of interferon-beta production, negative regulation of interleukin-6 production, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of tumor necrosis factor production, regulation of innate immune response, regulation of primary metabolic process; MF: ATP binding, nucleotide binding, phosphatidylinositol 3-kinase regulatory subunit binding, protein binding; CC: centriolar satellite, cytoplasm, cytosol, perinuclear region of cytoplasm
Pathways: Cytosolic sensors of pathogen-associated DNA , IRF3-mediated induction of type I IFN, Immune System, Innate Immune System, STING mediated induction of host immune responses
UniProt: Q7RTR2
Entrez ID: 197358
|
Does Knockout of DISP2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
DISP2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: DISP2 (dispatched RND transporter family member 2)
Type: protein-coding
Summary: This gene is one of two human homologs of a segment-polarity gene known as dispatched identified in Drosophila. The product of this gene may be required for normal Hedgehog (Hh) signaling during embryonic pattern formation. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: smoothened signaling pathway; CC: membrane, plasma membrane
Pathways: Hedgehog ligand biogenesis, Release of Hh-Np from the secreting cell, Signal Transduction, Signaling by Hedgehog
UniProt: A7MBM2
Entrez ID: 85455
|
Does Knockout of SLC35F3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
SLC35F3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SLC35F3 (solute carrier family 35 member F3)
Type: protein-coding
Summary: Involved in thiamine transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: thiamine transport
Pathways:
UniProt: Q8IY50
Entrez ID: 148641
|
Does Knockout of CNTLN in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
CNTLN
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: CNTLN (centlein)
Type: protein-coding
Summary: Enables protein domain specific binding activity; protein kinase binding activity; and protein-macromolecule adaptor activity. Involved in centriole-centriole cohesion and protein localization to organelle. Located in cytosol; microtubule organizing center; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: centriole-centriole cohesion, intracellular protein localization, protein localization to organelle, protein-containing complex assembly, regulation of protein localization, single fertilization, spermatogenesis; MF: protein binding, protein domain specific binding, protein kinase binding, protein-macromolecule adaptor activity; CC: centriole, centrosome, cytoplasm, cytoskeleton, cytosol, extracellular exosome, nucleoplasm, sperm head-tail coupling apparatus
Pathways:
UniProt: Q9NXG0
Entrez ID: 54875
|
Does Knockout of AMER2 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
AMER2
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: AMER2 (APC membrane recruitment protein 2)
Type: protein-coding
Summary: Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Wnt signaling pathway, ectoderm development, negative regulation of canonical Wnt signaling pathway, regulation of canonical Wnt signaling pathway; MF: beta-catenin binding, lipid binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q8N7J2
Entrez ID: 219287
|
Does Knockout of DCAF13 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,510
|
Knockout
|
DCAF13
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: DCAF13 (DDB1 and CUL4 associated factor 13)
Type: protein-coding
Summary: Enables estrogen receptor binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in several cellular components, including centrosome; cytosol; and nuclear lumen. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: decidualization, epigenetic programming in the zygotic pronuclei, female gamete generation, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, oocyte growth, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, rRNA processing, ribosome biogenesis, spindle assembly involved in female meiosis; MF: RNA binding, nuclear estrogen receptor binding, protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul4-RING E3 ubiquitin ligase complex, cell junction, centrosome, cytosol, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Neddylation, Post-translational protein modification, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NV06
Entrez ID: 25879
|
Does Knockout of SNTB2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
SNTB2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: SNTB2 (syntrophin beta 2)
Type: protein-coding
Summary: Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: RNA binding, actin binding, calmodulin binding, protein binding, structural molecule activity; CC: Golgi apparatus, anchoring junction, centriolar satellite, ciliary basal body, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, dystrophin-associated glycoprotein complex, focal adhesion, membrane, microtubule, nucleoplasm, plasma membrane, protein-containing complex, synapse, transport vesicle membrane
Pathways: Acebutolol Action Pathway, Alprenolol Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupranolol Action Pathway, Carteolol Action Pathway, Carvedilol Action Pathway, Diltiazem Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Epinephrine Action Pathway, Esmolol Action Pathway, Extracellular matrix organization, Felodipine Action Pathway, Flecainide Action Pathway, Formation of the dystrophin-glycoprotein complex (DGC), Fosphenytoin (Antiarrhythmic) Action Pathway, Fosphenytoin (Antiarrhythmic) Metabolism Pathway, Ibutilide Action Pathway, Isoprenaline Action Pathway, Isradipine Action Pathway, Labetalol Action Pathway, Levobunolol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Muscle/Heart Contraction, Nadolol Action Pathway, Nebivolol Action Pathway, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Non-integrin membrane-ECM interactions, Oxprenolol Action Pathway, Penbutolol Action Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Practolol Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Sotalol Action Pathway, Timolol Action Pathway, Tocainide Action Pathway, Verapamil Action Pathway
UniProt: Q13425
Entrez ID: 6645
|
Does Knockout of PNMA5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
PNMA5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PNMA5 (PNMA family member 5)
Type: protein-coding
Summary: This gene encodes a member of the paraneoplastic Ma antigen protein family. These proteins have been implicated in the development of paraneoplastic disorders resulting from an immune response directed against them. Paraneoplastic disorders are the result of an abnormal immune response to a tumor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2011].
Gene Ontology: MF: identical protein binding, protein binding; CC: nucleus
Pathways:
UniProt: Q96PV4
Entrez ID: 114824
|
Does Knockout of SLC4A7 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
SLC4A7
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: SLC4A7 (solute carrier family 4 member 7)
Type: protein-coding
Summary: This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: auditory receptor cell development, bicarbonate transport, cellular response to growth factor stimulus, inorganic anion transport, monoatomic anion transmembrane transport, monoatomic anion transport, monoatomic ion transport, phagosome acidification, purine nucleotide biosynthetic process, pyrimidine nucleotide biosynthetic process, regulation of intracellular pH, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: monoatomic anion transmembrane transporter activity, protein binding, sodium:bicarbonate symporter activity, solute:inorganic anion antiporter activity, symporter activity; CC: apical plasma membrane, basolateral plasma membrane, cell projection, membrane, plasma membrane, stereocilium
Pathways: Bicarbonate transporters, IL-18 signaling pathway, RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOH GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport of small molecules
UniProt: Q9Y6M7
Entrez ID: 9497
|
Does Knockout of MKS1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
MKS1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: MKS1 (MKS transition zone complex subunit 1)
Type: protein-coding
Summary: The protein encoded by this gene localizes to the basal body and is required for formation of the primary cilium in ciliated epithelial cells. Mutations in this gene result in Meckel syndrome type 1 and in Bardet-Biedl syndrome type 13. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: branching morphogenesis of an epithelial tube, cardiac septum morphogenesis, cell projection organization, cilium assembly, common bile duct development, determination of left/right symmetry, embryonic brain development, embryonic digit morphogenesis, embryonic skeletal system development, epithelial structure maintenance, head development, inner ear receptor cell stereocilium organization, motile cilium assembly, neural tube closure, non-motile cilium assembly, regulation of Wnt signaling pathway, planar cell polarity pathway, regulation of canonical Wnt signaling pathway, regulation of smoothened signaling pathway, smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation; CC: MKS complex, cell projection, centriole, centrosome, ciliary basal body, ciliary transition zone, cilium, cytoplasm, cytoskeleton, cytosol, membrane, nucleolus, nucleoplasm
Pathways: Anchoring of the basal body to the plasma membrane, Ciliary landscape, Ciliopathies, Cilium Assembly, Ectoderm Differentiation, Genes related to primary cilium development (based on CRISPR), Hedgehog 'off' state, Joubert Syndrome, Organelle biogenesis and maintenance, Signal Transduction, Signaling by Hedgehog
UniProt: Q9NXB0
Entrez ID: 54903
|
Does Knockout of HIRA in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
HIRA
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: HIRA (histone cell cycle regulator)
Type: protein-coding
Summary: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, anatomical structure morphogenesis, chromatin organization, chromatin remodeling, gastrulation, muscle cell differentiation, negative regulation of DNA-templated transcription, nucleosome assembly, osteoblast differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: RNA polymerase II-specific DNA-binding transcription factor binding, histone binding, nucleosome binding, protein binding, transcription corepressor activity; CC: HIR complex, PML body, chromatin, extracellular exosome, nucleoplasm, nucleus, protein-containing complex
Pathways: 16p11.2 proximal deletion syndrome, 22q11.2 copy number variation syndrome, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, DNA Damage/Telomere Stress Induced Senescence, Developmental Biology, Formation of Senescence-Associated Heterochromatin Foci (SAHF), Maternal to zygotic transition (MZT), Replacement of protamines by nucleosomes in the male pronucleus
UniProt: P54198
Entrez ID: 7290
|
Does Knockout of RPL32 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
RPL32
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPL32 (ribosomal protein L32)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62910
Entrez ID: 6161
|
Does Knockout of HTATSF1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
HTATSF1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: HTATSF1 (HIV-1 Tat specific factor 1)
Type: protein-coding
Summary: The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009].
Gene Ontology: BP: DNA damage response, DNA repair, RNA splicing, U2-type prespliceosome assembly, chromatin organization, double-strand break repair via homologous recombination, mRNA processing, mRNA splicing, via spliceosome, protein localization to site of double-strand break; MF: RNA binding, chromatin-protein adaptor activity, nucleic acid binding, poly-ADP-D-ribose modification-dependent protein binding, protein binding; CC: U2 snRNP, U2-type spliceosomal complex, chromosome, nucleoplasm, nucleus, site of double-strand break, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O43719
Entrez ID: 27336
|
Does Knockout of VHL in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
VHL
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: VHL (von Hippel-Lindau tumor suppressor)
Type: protein-coding
Summary: This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [provided by RefSeq, Jun 2022].
Gene Ontology: BP: amyloid fibril formation, cell morphogenesis, cellular response to hypoxia, negative regulation of TORC1 signaling, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of macromolecule biosynthetic process, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of signal transduction, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of cell differentiation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization, protein ubiquitination, proteolysis, regulation of DNA-templated transcription, regulation of cellular response to hypoxia, regulation of gene expression, response to hypoxia; MF: DNA-binding transcription factor binding, enzyme binding, molecular adaptor activity, protein binding, protein serine/threonine kinase binding, transcription elongation factor activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activity; CC: cilium, cytoplasm, cytosol, endoplasmic reticulum, membrane, microtubule cytoskeleton, mitochondrion, nucleoplasm, nucleus, plasma membrane
Pathways: Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, HIF-1 signaling pathway - Homo sapiens (human), HIF-2-alpha transcription factor network, Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, Pathways in cancer - Homo sapiens (human), Pathways in clear cell renal cell carcinoma, Renal cell carcinoma - Homo sapiens (human), Type 2 papillary renal cell carcinoma, Ubiquitin mediated proteolysis - Homo sapiens (human), hypoxia-inducible factor in the cardivascular system, vegf hypoxia and angiogenesis
UniProt: P40337
Entrez ID: 7428
|
Does Knockout of WRAP73 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
WRAP73
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: WRAP73 (WD repeat containing, antisense to TP73)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: cell projection organization, mitotic spindle assembly, positive regulation of non-motile cilium assembly; CC: MWP complex, centriolar satellite, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, microtubule organizing center
Pathways:
UniProt: Q9P2S5
Entrez ID: 49856
|
Does Knockout of MIR6869 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
MIR6869
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: MIR6869 (microRNA 6869)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cellular response to lipopolysaccharide, miRNA-mediated post-transcriptional gene silencing, negative regulation of inflammatory response to antigenic stimulus, negative regulation of interleukin-6 production, negative regulation of tumor necrosis factor production
Pathways:
UniProt:
Entrez ID: 102465524
|
Does Knockout of LRRC56 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
LRRC56
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: LRRC56 (leucine rich repeat containing 56)
Type: protein-coding
Summary: Predicted to be involved in cell projection organization. Predicted to be located in cilium. Implicated in primary ciliary dyskinesia 39. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell projection, cilium
Pathways:
UniProt: Q8IYG6
Entrez ID: 115399
|
Does Knockout of SEC13 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
SEC13
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: SEC13 (SEC13 homolog, nuclear pore and COPII component)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: COPII-coated vesicle budding, COPII-coated vesicle cargo loading, cellular response to nutrient levels, intracellular protein transport, mRNA transport, negative regulation of TORC1 signaling, nucleocytoplasmic transport, positive regulation of TOR signaling, positive regulation of TORC1 signaling, protein exit from endoplasmic reticulum, protein import into nucleus, protein transport, vesicle-mediated transport; MF: identical protein binding, protein binding, structural molecule activity; CC: COPII vesicle coat, ER to Golgi transport vesicle membrane, GATOR2 complex, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, kinetochore, lysosomal membrane, lysosome, membrane, nuclear envelope, nuclear pore, nuclear pore outer ring, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), RNA transport - Homo sapiens (human), Sterol regulatory element-binding proteins (SREBP) signaling, mTOR signaling pathway - Homo sapiens (human)
UniProt: P55735
Entrez ID: 6396
|
Does Knockout of CACNA2D4 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
CACNA2D4
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: CACNA2D4 (calcium voltage-gated channel auxiliary subunit alpha2delta 4)
Type: protein-coding
Summary: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, detection of light stimulus involved in visual perception, monoatomic ion transmembrane transport, monoatomic ion transport; MF: calcium channel activity, metal ion binding, voltage-gated calcium channel activity; CC: membrane, monoatomic ion channel complex, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Dilated cardiomyopathy - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Oxytocin signaling pathway - Homo sapiens (human)
UniProt: Q7Z3S7
Entrez ID: 93589
|
Does Knockout of PGA3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
PGA3
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: PGA3 (pepsinogen A3)
Type: protein-coding
Summary: This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: digestion, proteolysis; MF: aspartic-type endopeptidase activity, hydrolase activity, peptidase activity; CC: extracellular exosome, extracellular region, multivesicular body lumen
Pathways: Metabolism of proteins, Protein digestion and absorption - Homo sapiens (human), Surfactant metabolism
UniProt: P0DJD8
Entrez ID: 643834
|
Does Knockout of ESPL1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
ESPL1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ESPL1 (extra spindle pole bodies like 1, separase)
Type: protein-coding
Summary: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: apoptotic process, chromosome segregation, establishment of mitotic spindle localization, homologous chromosome segregation, meiosis I, meiotic chromosome separation, meiotic spindle organization, mitotic cell cycle, mitotic cytokinesis, mitotic sister chromatid segregation, mitotic sister chromatid separation, negative regulation of sister chromatid cohesion, nuclear chromosome segregation, nuclear division, positive regulation of mitotic metaphase/anaphase transition, proteolysis; MF: catalytic activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding; CC: centrosome, cytoplasm, cytosol, mitotic spindle, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Oocyte meiosis - Homo sapiens (human), Regulation of sister chromatid separation at the metaphase-anaphase transition, Separation of Sister Chromatids
UniProt: Q14674
Entrez ID: 9700
|
Does Knockout of BRAP in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
BRAP
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: BRAP (BRCA1 associated protein)
Type: protein-coding
Summary: The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, Ras protein signal transduction, negative regulation of signal transduction, protein ubiquitination; MF: identical protein binding, metal ion binding, nuclear localization sequence binding, nucleic acid binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nuclear membrane, nucleoplasm, ubiquitin ligase complex
Pathways: Disease, Diseases of signal transduction by growth factor receptors and second messengers, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of MAPK pathway, Oncogenic MAPK signaling, Paradoxical activation of RAF signaling by kinase inactive BRAF, RAF activation, RAF/MAP kinase cascade, Ras signaling, Ras signaling pathway - Homo sapiens (human), Signal Transduction, Signaling by RAS mutants, Signaling by moderate kinase activity BRAF mutants, Signaling downstream of RAS mutants
UniProt: Q7Z569
Entrez ID: 8315
|
Does Knockout of GCK in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
GCK
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: GCK (glucokinase)
Type: protein-coding
Summary: This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: NADP+ metabolic process, calcium ion import, canonical glycolysis, carbohydrate metabolic process, carbohydrate phosphorylation, cellular response to insulin stimulus, cellular response to leptin stimulus, glucose 6-phosphate metabolic process, glucose catabolic process, glucose homeostasis, glucose metabolic process, glycolytic process, hexose metabolic process, intracellular glucose homeostasis, negative regulation of gluconeogenesis, nicotinamide nucleotide metabolic process, positive regulation of glycogen biosynthetic process, positive regulation of insulin secretion, purine nucleotide metabolic process, regulation of glycolytic process, regulation of insulin secretion, regulation of potassium ion transport, response to glucose; MF: ATP binding, D-glucose binding, catalytic activity, fructokinase activity, glucokinase activity, glucose sensor activity, hexokinase activity, kinase activity, mannokinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein binding, transferase activity; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Central carbon metabolism in cancer - Homo sapiens (human), Defective GCK causes maturity-onset diabetes of the young 2 (MODY2), Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Developmental Biology, Disease, Disorders of transmembrane transporters, FOXA2 and FOXA3 transcription factor networks, FOXO-mediated transcription, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, GDP-glucose biosynthesis II, Galactose Metabolism, Galactose metabolism - Homo sapiens (human), Galactosemia, Galactosemia II (GALK), Galactosemia III, Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling pathway - Homo sapiens (human), Glucose metabolism, Glycogen synthetase deficiency, Glycogenosis, Type III. Cori disease, Debrancher glycogenosis, Glycogenosis, Type IV. Amylopectinosis, Anderson disease, Glycogenosis, Type VI. Hers disease, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, HIF-1-alpha transcription factor network, Insulin secretion - Homo sapiens (human), Insulin signaling pathway - Homo sapiens (human), Maturity onset diabetes of the young - Homo sapiens (human), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Mucopolysaccharidosis VI. Sly syndrome, Neomycin, kanamycin and gentamicin biosynthesis - Homo sapiens (human), Nucleotide Sugars Metabolism, Prolactin signaling pathway - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of beta-cell development, Regulation of gene expression in beta cells, SLC transporter disorders, Starch and Sucrose Metabolism, Starch and sucrose metabolism - Homo sapiens (human), Sucrase-isomaltase deficiency, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Trehalose Degradation, Type II diabetes mellitus - Homo sapiens (human), UDP-<i>N</i>-acetyl-D-galactosamine biosynthesis II, glycolysis, mapkinase signaling pathway, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle, trehalose degradation
UniProt: P35557
Entrez ID: 2645
|
Does Knockout of GLUD1 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
GLUD1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: GLUD1 (glutamate dehydrogenase 1)
Type: protein-coding
Summary: This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: L-glutamate catabolic process, amino acid metabolic process, glutamate biosynthetic process, glutamine metabolic process, positive regulation of insulin secretion, substantia nigra development, tricarboxylic acid metabolic process; MF: ADP binding, ATP binding, GTP binding, L-leucine binding, NAD+ binding, glutamate dehydrogenase (NAD+) activity, glutamate dehydrogenase (NADP+) activity, glutamate dehydrogenase [NAD(P)+] activity, nucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor, protein binding, protein homodimerization activity; CC: cytoplasm, endoplasmic reticulum, mitochondrial matrix, mitochondrion
Pathways: 2-Hydroxyglutric Aciduria (D And L Form), 22q11.2 copy number variation syndrome, 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency, Alanine, aspartate and glutamate metabolism - Homo sapiens (human), Amino Acid Metabolism Pathway Excerpt (Histidine catabolism extension), Amino Acid metabolism, Ammonia Recycling, Arginine and Proline Metabolism, Arginine biosynthesis - Homo sapiens (human), Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency), Argininemia, Argininosuccinic Aciduria, Carbamoyl Phosphate Synthetase Deficiency, Citrullinemia Type I, Creatine deficiency, guanidinoacetate methyltransferase deficiency, D-Glutamine and D-glutamate metabolism - Homo sapiens (human), GABA shunt, Glucose-Alanine Cycle, Glutamate Metabolism, Glutamate and glutamine metabolism, Glutaminolysis and Cancer, Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency), Homocarnosinosis, Hyperinsulinism-Hyperammonemia Syndrome, Hyperornithinemia with gyrate atrophy (HOGA), Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome], Hyperprolinemia Type I, Hyperprolinemia Type II, L-arginine:glycine amidinotransferase deficiency, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Mitochondrial biogenesis, Mitochondrial protein degradation, Necroptosis - Homo sapiens (human), Nitrogen metabolism - Homo sapiens (human), Organelle biogenesis and maintenance, Ornithine Aminotransferase Deficiency (OAT Deficiency), Ornithine Transcarbamylase Deficiency (OTC Deficiency), Prolidase Deficiency (PD), Prolinemia Type II, Proximal tubule bicarbonate reclamation - Homo sapiens (human), Succinic semialdehyde dehydrogenase deficiency, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, Transcriptional activation of mitochondrial biogenesis, Urea Cycle, VEGFA-VEGFR2 Signaling Pathway, Warburg Effect, glutamate biosynthesis/degradation, ornithine <i>de novo </i> biosynthesis
UniProt: P00367
Entrez ID: 2746
|
Does Knockout of ATP6V1G2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
ATP6V1G2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: ATP6V1G2 (ATPase H+ transporting V1 subunit G2)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification; MF: ATP hydrolysis activity, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: clathrin-coated vesicle membrane, cytoplasmic vesicle, cytosol, extrinsic component of synaptic vesicle membrane, melanosome, membrane, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), ROS and RNS production in phagocytes, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Vibrio cholerae infection - Homo sapiens (human), mTOR signaling pathway - Homo sapiens (human)
UniProt: O95670
Entrez ID: 534
|
Does Knockout of AADACL3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
AADACL3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: AADACL3 (arylacetamide deacetylase like 3)
Type: protein-coding
Summary: Predicted to enable hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: carboxylic ester hydrolase activity, hydrolase activity
Pathways:
UniProt: Q5VUY0
Entrez ID: 126767
|
Does Knockout of SIRT6 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
SIRT6
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SIRT6 (sirtuin 6)
Type: protein-coding
Summary: This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, Ras protein signal transduction, base-excision repair, cardiac muscle cell differentiation, chromatin organization, chromatin remodeling, circadian regulation of gene expression, determination of adult lifespan, double-strand break repair, gluconeogenesis, glucose homeostasis, glycolytic process, inflammatory response, ketone biosynthetic process, negative regulation of D-glucose import, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of cellular senescence, negative regulation of gene expression, epigenetic, negative regulation of gluconeogenesis, negative regulation of glycolytic process, negative regulation of protein import into nucleus, negative regulation of protein localization to chromatin, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, pericentric heterochromatin formation, positive regulation of blood vessel branching, positive regulation of cellular senescence, positive regulation of chondrocyte proliferation, positive regulation of cold-induced thermogenesis, positive regulation of double-strand break repair, positive regulation of fat cell differentiation, positive regulation of fibroblast proliferation, positive regulation of gluconeogenesis, positive regulation of insulin secretion, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein export from nucleus, positive regulation of protein localization to chromatin, positive regulation of stem cell differentiation, positive regulation of stem cell population maintenance, positive regulation of stem cell proliferation, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial cell proliferation, protein deacetylation, protein delipidation, protein destabilization, protein import into nucleus, protein localization to site of double-strand break, protein poly-ADP-ribosylation, regulation of DNA repair, regulation of circadian rhythm, regulation of double-strand break repair via homologous recombination, regulation of gluconeogenesis, regulation of lipid catabolic process, regulation of lipid metabolic process, regulation of protein localization to plasma membrane, regulation of protein secretion, response to UV, subtelomeric heterochromatin formation, transcription pausing by RNA polymerase II, transposable element silencing; MF: DNA binding, DNA damage sensor activity, NAD+ binding, NAD+ poly-ADP-ribosyltransferase activity, NAD+-protein mono-ADP-ribosyltransferase activity, NAD+-protein-arginine ADP-ribosyltransferase activity, NAD+-protein-lysine ADP-ribosyltransferase activity, NAD-dependent protein demyristoylase activity, NAD-dependent protein depalmitoylase activity, NAD-dependent protein lysine deacetylase activity, RNA binding, TORC2 complex binding, acyltransferase activity, chromatin DNA binding, chromatin binding, damaged DNA binding, enzyme regulator activity, glycosyltransferase activity, histone H3K18 deacetylase activity, NAD-dependent, histone H3K56 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, hydrolytic mechanism, histone deacetylase activity, NAD-dependent, histone deacetylase regulator activity, metal ion binding, nucleosome binding, nucleotidyltransferase activity, protein binding, protein homodimerization activity, transcription corepressor activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, chromosome, subtelomeric region, chromosome, telomeric region, endoplasmic reticulum, nucleolus, nucleoplasm, nucleus, pericentric heterochromatin, site of DNA damage, site of double-strand break
Pathways: Central carbon metabolism in cancer - Homo sapiens (human), DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, NAD+ biosynthetic pathways, NAD+ metabolism, Nicotinate and nicotinamide metabolism - Homo sapiens (human), Pre-NOTCH Expression and Processing, Pre-NOTCH Transcription and Translation, Processing of DNA double-strand break ends, SREBF and miR33 in cholesterol and lipid homeostasis, Signal Transduction, Signaling by NOTCH, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects
UniProt: Q8N6T7
Entrez ID: 51548
|
Does Knockout of SEC14L5 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
SEC14L5
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: SEC14L5 (SEC14 like lipid binding 5)
Type: protein-coding
Summary: Predicted to be located in mitochondrial intermembrane space. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: O43304
Entrez ID: 9717
|
Does Knockout of EIF3E in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
EIF3E
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: EIF3E (eukaryotic translation initiation factor 3 subunit E)
Type: protein-coding
Summary: Enables protein N-terminus binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; regulation of gene expression; and translational initiation. Located in cytosol and nucleus. Part of eukaryotic translation initiation factor 3 complex. Colocalizes with PML body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, negative regulation of translational initiation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of translation, regulation of translational initiation, translation, translational initiation; MF: RNA binding, cadherin binding, protein binding, translation initiation factor activity; CC: PML body, chromatin, cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3e, extracellular exosome, membrane, nucleoplasm, nucleus, postsynaptic density, protein-containing complex
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, HIF-2-alpha transcription factor network, Hepatitis C - Homo sapiens (human), L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: P60228
Entrez ID: 3646
|
Does Knockout of NRIP3 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
NRIP3
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: NRIP3 (nuclear receptor interacting protein 3)
Type: protein-coding
Summary: Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: aspartic-type endopeptidase activity, protein binding
Pathways:
UniProt: Q9NQ35
Entrez ID: 56675
|
Does Knockout of CLDN16 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
CLDN16
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: CLDN16 (claudin 16)
Type: protein-coding
Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: bicellular tight junction assembly, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion, intercellular transport, intracellular monoatomic cation homeostasis, magnesium ion transmembrane transport, metal ion transport, monoatomic ion transport, paracellular transport, renal absorption; MF: PDZ domain binding, identical protein binding, magnesium ion transmembrane transporter activity, paracellular tight junction channel activity, protein binding, structural molecule activity; CC: anchoring junction, bicellular tight junction, membrane, plasma membrane, tight junction
Pathways: Cell adhesion molecules - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Epithelial to mesenchymal transition in colorectal cancer, Hepatitis C - Homo sapiens (human), Leukocyte transendothelial migration - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Tight junction - Homo sapiens (human), Tight junction interactions
UniProt: Q9Y5I7
Entrez ID: 10686
|
Does Knockout of UQCRH in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
UQCRH
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: UQCRH (ubiquinol-cytochrome c reductase hinge protein)
Type: protein-coding
Summary: Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: aerobic respiration, cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, oxidative phosphorylation, proton transmembrane transport; MF: protein binding, quinol-cytochrome-c reductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Complex III assembly, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Mitochondrial complex III assembly, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: P07919
Entrez ID: 7388
|
Does Knockout of PMAIP1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
PMAIP1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1)
Type: protein-coding
Summary: This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: DNA damage response, T cell homeostasis, apoptotic process, cellular response to glucose starvation, cellular response to hypoxia, defense response to virus, intrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of mitochondrial membrane potential, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of apoptotic process, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of glucose metabolic process, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of release of cytochrome c from mitochondria, proteasomal protein catabolic process, reactive oxygen species metabolic process, regulation of mitochondrial membrane permeability, release of cytochrome c from mitochondria, response to dsRNA; CC: Bcl-2 family protein complex, cytosol, mitochondrial outer membrane, mitochondrion, nucleus
Pathways: Activation of BH3-only proteins, Activation of NOXA and translocation to mitochondria, Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis - multiple species - Homo sapiens (human), Apoptosis Modulation and Signaling, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, Chromosomal and microsatellite instability in colorectal cancer, Colorectal cancer - Homo sapiens (human), DNA damage response, DNA damage response (only ATM dependent), Direct p53 effectors, Gene expression (Transcription), Generic Transcription Pathway, H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity, Intrinsic Pathway for Apoptosis, Pathways in cancer - Homo sapiens (human), Photodynamic therapy-induced HIF-1 survival signaling, Programmed Cell Death, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, TP53 network, Transcriptional Regulation by TP53, Unfolded protein response, Validated targets of C-MYC transcriptional activation, Validated transcriptional targets of TAp63 isoforms, Viral carcinogenesis - Homo sapiens (human), miRNA regulation of DNA damage response, miRNA regulation of p53 pathway in prostate cancer, p53 signaling pathway - Homo sapiens (human), p53 transcriptional gene network
UniProt: Q13794
Entrez ID: 5366
|
Does Knockout of CDH4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
CDH4
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: CDH4 (cadherin 4)
Type: protein-coding
Summary: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: adherens junction organization, axon extension, axon guidance, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, positive regulation of axon extension; MF: beta-catenin binding, cadherin binding, calcium ion binding, metal ion binding; CC: adherens junction, catenin complex, membrane, plasma membrane
Pathways: Adherens junctions interactions, Cell adhesion molecules - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Developmental Biology, Hippo-Merlin Signaling Dysregulation, Myogenesis, Pathways Regulating Hippo Signaling
UniProt: P55283
Entrez ID: 1002
|
Does Knockout of PRSS3 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
PRSS3
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: PRSS3 (serine protease 3)
Type: protein-coding
Summary: This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010].
Gene Ontology: BP: antimicrobial humoral response, digestion, endothelial cell migration, proteolysis, zymogen activation; MF: calcium ion binding, hydrolase activity, metal ion binding, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region, extracellular space, tertiary granule lumen
Pathways: Alpha-defensins, Antimicrobial peptides, Cobalamin (Cbl, vitamin B12) transport and metabolism, Defensins, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin, Immune System, Influenza A - Homo sapiens (human), Innate Immune System, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Neuroactive ligand-receptor interaction - Homo sapiens (human), Neutrophil degranulation, Pancreatic secretion - Homo sapiens (human), Protein digestion and absorption - Homo sapiens (human), Uptake of dietary cobalamins into enterocytes
UniProt: P35030
Entrez ID: 5646
|
Does Knockout of HNRNPUL1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
HNRNPUL1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U like 1)
Type: protein-coding
Summary: This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: RNA processing, alternative mRNA splicing, via spliceosome, response to virus; MF: RNA binding, enzyme binding, protein binding; CC: nucleoplasm, nucleus, ribonucleoprotein complex, synapse
Pathways: Influenza A - Homo sapiens (human)
UniProt: Q9BUJ2
Entrez ID: 11100
|
Does Knockout of ZNF594 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
ZNF594
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: ZNF594 (zinc finger protein 594)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q96JF6
Entrez ID: 84622
|
Does Knockout of PSMD12 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
PSMD12
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: PSMD12 (proteasome 26S subunit, non-ATPase 12)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: CC: cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, nucleoplasm, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: O00232
Entrez ID: 5718
|
Does Knockout of CXorf66 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
CXorf66
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: CXorf66 (chromosome X open reading frame 66)
Type: protein-coding
Summary: The protein encoded by this gene is predicted to be a type I membrane protein, however, its exact function is not known. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt: Q5JRM2
Entrez ID: 347487
|
Does Knockout of BCL9L in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
BCL9L
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: BCL9L (BCL9 like)
Type: protein-coding
Summary: Enables beta-catenin binding activity. Involved in several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; and positive regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: canonical Wnt signaling pathway, myoblast differentiation, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of epithelial to mesenchymal transition, positive regulation of transcription by RNA polymerase II, regulation of cell morphogenesis, skeletal muscle cell differentiation, somatic stem cell population maintenance, transcription by RNA polymerase II; MF: beta-catenin binding, transcription coactivator activity; CC: beta-catenin-TCF complex, fibrillar center, nucleoplasm, nucleus
Pathways: Deactivation of the beta-catenin transactivating complex, Formation of the beta-catenin:TCF transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q86UU0
Entrez ID: 283149
|
Does Knockout of TXNDC15 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
TXNDC15
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: TXNDC15 (thioredoxin domain containing 15)
Type: protein-coding
Summary: This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. [provided by RefSeq, Apr 2017].
Gene Ontology: BP: cell projection organization, cilium assembly, positive regulation of smoothened signaling pathway; CC: cell projection, ciliary membrane, cilium, membrane, plasma membrane
Pathways: Genes related to primary cilium development (based on CRISPR)
UniProt: Q96J42
Entrez ID: 79770
|
Does Knockout of GGTLC2 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
GGTLC2
|
cell proliferation
|
Bladder Carcinoma
|
Gene: GGTLC2 (gamma-glutamyltransferase light chain 2)
Type: protein-coding
Summary: This gene encodes a protein related to enzymes that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides. Unlike similar proteins, the encoded protein contains only the light chain portion and may not have catalytic activity. Alternative splicing results in multiple transcript variants. There are several related family members and related pseudogene for this gene situated in the same region of chromosome 22. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: glutathione catabolic process, leukotriene D4 biosynthetic process; MF: glutathione hydrolase activity, protein binding
Pathways:
UniProt: Q14390
Entrez ID: 91227
|
Does Knockout of CYCS in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
CYCS
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: CYCS (cytochrome c, somatic)
Type: protein-coding
Summary: This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010].
Gene Ontology: BP: apoptotic process, apoptotic signaling pathway, cellular respiration, execution phase of apoptosis, intrinsic apoptotic signaling pathway, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial electron transport, ubiquinol to cytochrome c; MF: electron transfer activity, heme binding, metal ion binding, protein binding; CC: apoptosome, cytosol, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, nucleus
Pathways: AGE-RAGE pathway, Acute viral myocarditis, Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis - multiple species - Homo sapiens (human), Apoptosis Modulation and Signaling, Apoptosis Modulation by HSP70, BCR, Caspase Cascade in Apoptosis, Ceramide signaling pathway, Chromosomal and microsatellite instability in colorectal cancer, Colorectal cancer - Homo sapiens (human), DNA damage response, Epstein-Barr virus infection - Homo sapiens (human), Fas ligand pathway and stress induction of heat shock proteins, HIV-1 Nef: Negative effector of Fas and TNF-alpha, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), IL-18 signaling pathway, Influenza A - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Legionellosis - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Measles - Homo sapiens (human), Mitochondrial Electron Transport Chain, NO-cGMP-PKG mediated Neuroprotection, Nanomaterial induced apoptosis, Non-alcoholic fatty liver disease - Homo sapiens (human), Non-small cell lung cancer, Nonalcoholic fatty liver disease, Oxidative Damage, Parkinson disease - Homo sapiens (human), Parkinson,s disease pathway, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), RAGE, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Spinocerebellar ataxia - Homo sapiens (human), Toxoplasmosis - Homo sapiens (human), Tuberculosis - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, Viral myocarditis - Homo sapiens (human), apoptotic signaling in response to dna damage, ceramide signaling pathway, hiv-1 nef: negative effector of fas and tnf, mTOR signaling pathway, miRNA regulation of DNA damage response, p53 signaling pathway - Homo sapiens (human), p75(NTR)-mediated signaling, regulation of cell cycle progression by plk3, role of mitochondria in apoptotic signaling, stress induction of hsp regulation, trefoil factors initiate mucosal healing, west nile virus
UniProt: P99999
Entrez ID: 54205
|
Does Knockout of GID8 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
GID8
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GID8 (GID complex subunit 8 homolog)
Type: protein-coding
Summary: Predicted to enable protein homodimerization activity. Involved in positive regulation of canonical Wnt signaling pathway and positive regulation of cell population proliferation. Located in cell junction; cytosol; and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: protein binding, protein homodimerization activity; CC: cell junction, cytoplasm, cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Ciliary landscape, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: Q9NWU2
Entrez ID: 54994
|
Does Activation of IRAK3 in T cell causally result in protein/peptide accumulation?
| 1
| 2,426
|
Activation
|
IRAK3
|
protein/peptide accumulation
|
T cell
|
Gene: IRAK3 (interleukin 1 receptor associated kinase 3)
Type: protein-coding
Summary: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Gene Ontology: BP: MyD88-dependent toll-like receptor signaling pathway, Toll signaling pathway, cytokine-mediated signaling pathway, interleukin-1-mediated signaling pathway, intracellular signal transduction, lipopolysaccharide-mediated signaling pathway, negative regulation of MAPK cascade, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cytokine-mediated signaling pathway, negative regulation of innate immune response, negative regulation of interleukin-12 production, negative regulation of interleukin-6 production, negative regulation of macrophage cytokine production, negative regulation of protein catabolic process, negative regulation of protein-containing complex disassembly, negative regulation of toll-like receptor signaling pathway, negative regulation of tumor necrosis factor production, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cytokine production, positive regulation of immune system process, positive regulation of macrophage tolerance induction, protein phosphorylation, regulation of innate immune response, regulation of protein-containing complex disassembly, response to exogenous dsRNA, response to interleukin-1, response to lipopolysaccharide, response to peptidoglycan, response to virus, signal transduction; MF: ATP binding, magnesium ion binding, nucleotide binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity; CC: cytoplasm, nucleus, plasma membrane
Pathways: Cytokine Signaling in Immune system, IL-1 signaling pathway, IL1, IL1-mediated signaling events, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Neurotrophin signaling pathway - Homo sapiens (human), Regulation of toll-like receptor signaling pathway, Signal transduction through IL1R, Signaling by Interleukins, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, signal transduction through il1r
UniProt: Q9Y616
Entrez ID: 11213
|
Does Knockout of ZNF578 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
ZNF578
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: ZNF578 (zinc finger protein 578)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, nucleus
Pathways: Herpes simplex virus 1 infection - Homo sapiens (human)
UniProt: Q96N58
Entrez ID: 147660
|
Does Knockout of ARL13B in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
ARL13B
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: ARL13B (ARF like GTPase 13B)
Type: protein-coding
Summary: This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in this gene are the cause of Joubert syndrome 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: cilium assembly, determination of left/right symmetry, dorsal/ventral pattern formation, formation of radial glial scaffolds, heart looping, interneuron migration from the subpallium to the cortex, left/right axis specification, neural tube patterning, non-motile cilium assembly, receptor localization to non-motile cilium, smoothened signaling pathway; MF: GTP binding, GTPase activity, nucleotide binding, protein binding; CC: axoneme, cell projection, ciliary basal body, ciliary membrane, cilium, cytoplasm, cytoskeleton, cytosol, intercellular bridge, membrane, microtubule cytoskeleton, motile cilium, non-motile cilium, plasma membrane
Pathways: ARL13B-mediated ciliary trafficking of INPP5E, Aggrephagy, Autophagy, Cargo trafficking to the periciliary membrane, Chaperone Mediated Autophagy, Ciliopathies, Cilium Assembly, Genes related to primary cilium development (based on CRISPR), Joubert Syndrome, Late endosomal microautophagy, Macroautophagy, Organelle biogenesis and maintenance, RHO GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, Selective autophagy, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q3SXY8
Entrez ID: 200894
|
Does Knockout of GEMIN5 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
GEMIN5
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GEMIN5 (gem nuclear organelle associated protein 5)
Type: protein-coding
Summary: This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, protein-containing complex assembly, regulation of translation, spliceosomal snRNP assembly, translation; MF: RNA 7-methylguanosine cap binding, RNA binding, U1 snRNA binding, U4 snRNA binding, U4atac snRNA binding, mRNA 3'-UTR binding, protein binding, ribosome binding, snRNA binding; CC: Gemini of Cajal bodies, SMN complex, SMN-Gemin2 complex, SMN-Sm protein complex, cytoplasm, cytosol, membrane, nuclear body, nucleoplasm, nucleus
Pathways: Disease, Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, RNA transport - Homo sapiens (human), SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, Viral Infection Pathways, snRNP Assembly
UniProt: Q8TEQ6
Entrez ID: 25929
|
Does Knockout of RBPJ in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
RBPJ
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: RBPJ (recombination signal binding protein for immunoglobulin kappa J region)
Type: protein-coding
Summary: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013].
Gene Ontology: BP: B cell differentiation, Notch signaling pathway, angiogenesis, animal organ development, aortic valve development, arterial endothelial cell fate commitment, artery morphogenesis, atrioventricular canal development, auditory receptor cell fate commitment, blood vessel endothelial cell fate specification, blood vessel lumenization, blood vessel remodeling, cardiac left ventricle morphogenesis, cardiac muscle cell myoblast differentiation, cell differentiation, cell fate commitment, cell population proliferation, club cell differentiation, defense response to bacterium, dorsal aorta morphogenesis, endocardium development, endocardium morphogenesis, epidermal cell fate specification, epithelial cell proliferation, epithelial to mesenchymal transition, epithelial to mesenchymal transition involved in endocardial cushion formation, hair follicle maturation, heart development, hemopoiesis, humoral immune response, inflammatory response to antigenic stimulus, keratinocyte differentiation, labyrinthine layer blood vessel development, myeloid dendritic cell differentiation, negative regulation of DNA-templated transcription, negative regulation of cell differentiation, negative regulation of cold-induced thermogenesis, negative regulation of ossification, negative regulation of stem cell proliferation, negative regulation of transcription by RNA polymerase II, neuron differentiation, outflow tract morphogenesis, pituitary gland development, positive regulation of BMP signaling pathway, positive regulation of ERBB signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of cardiac muscle cell proliferation, positive regulation of cell proliferation involved in heart morphogenesis, positive regulation of ephrin receptor signaling pathway, positive regulation of epithelial cell proliferation, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of Notch receptor target, pulmonary valve development, regulation of DNA-templated transcription, regulation of cell adhesion involved in heart morphogenesis, regulation of epithelial cell proliferation, regulation of gene expression, regulation of generation of precursor metabolites and energy, regulation of timing of cell differentiation, regulation of transcription by RNA polymerase II, sebaceous gland development, secondary heart field specification, somatic stem cell population maintenance, somitogenesis, stem cell proliferation, ventricular septum morphogenesis, ventricular trabecula myocardium morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, protein binding, sequence-specific DNA binding; CC: MAML1-RBP-Jkappa- ICN1 complex, chromatin, cytoplasm, nucleolus, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Canonical and non-canonical Notch signaling, Epithelial to mesenchymal transition in colorectal cancer, Epstein-Barr virus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Neural Crest Differentiation, Notch, Notch Signaling, Notch Signaling Pathway Netpath, Notch signaling pathway, Notch signaling pathway - Homo sapiens (human), Notch-mediated HES/HEY network, Osteoblast differentiation, PTF1A related regulatory pathway, Presenilin action in Notch and Wnt signaling, Spinocerebellar ataxia - Homo sapiens (human), Th1 and Th2 cell differentiation - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), proteolysis and signaling pathway of notch, segmentation clock
UniProt: Q06330
Entrez ID: 3516
|
Does Knockout of TTC27 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
TTC27
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: TTC27 (tetratricopeptide repeat domain 27)
Type: protein-coding
Summary: tetratricopeptide repeat domain 27
Gene Ontology:
Pathways:
UniProt: Q6P3X3
Entrez ID: 55622
|
Does Knockout of RPL3 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
RPL3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: RPL3 (ribosomal protein L3)
Type: protein-coding
Summary: Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to interleukin-4, cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, nucleolus, nucleus, protein-containing complex, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P39023
Entrez ID: 6122
|
Does Knockout of LENG1 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
LENG1
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: LENG1 (leukocyte receptor cluster member 1)
Type: protein-coding
Summary: Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q96BZ8
Entrez ID: 79165
|
Does Knockout of HAS2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
HAS2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: HAS2 (hyaluronan synthase 2)
Type: protein-coding
Summary: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: atrioventricular canal development, bone morphogenesis, cellular response to fluid shear stress, cellular response to interleukin-1, cellular response to platelet-derived growth factor stimulus, cellular response to tumor necrosis factor, endocardial cushion to mesenchymal transition, estrous cycle, extracellular matrix assembly, glycosaminoglycan biosynthetic process, hyaluronan biosynthetic process, hyaluronan metabolic process, kidney development, polysaccharide biosynthetic process, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of hyaluronan biosynthetic process, positive regulation of keratinocyte migration, positive regulation of keratinocyte proliferation, positive regulation of monocyte aggregation, positive regulation of smooth muscle cell migration, positive regulation of substrate adhesion-dependent cell spreading, positive regulation of urine volume, regulation of extracellular matrix assembly, renal water absorption, vasculogenesis; MF: glycosyltransferase activity, hyaluronan synthase activity, identical protein binding, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular vesicle, lysosome, membrane, plasma membrane, plasma membrane raft, vesicle
Pathways: Glycosaminoglycan metabolism, Hyaluronan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q92819
Entrez ID: 3037
|
Does Knockout of TP53 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
TP53
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: TP53 (tumor protein p53)
Type: protein-coding
Summary: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].
Gene Ontology: BP: B cell lineage commitment, DNA damage response, DNA damage response, signal transduction by p53 class mediator, ER overload response, Ras protein signal transduction, T cell differentiation in thymus, T cell lineage commitment, T cell proliferation involved in immune response, apoptotic process, apoptotic signaling pathway, autophagy, bone marrow development, cardiac muscle cell apoptotic process, cardiac septum morphogenesis, cell population proliferation, cellular response to UV, cellular response to UV-C, cellular response to actinomycin D, cellular response to gamma radiation, cellular response to glucose starvation, cellular response to hypoxia, cellular response to ionizing radiation, cellular response to stress, cellular response to xenobiotic stimulus, cellular senescence, central nervous system development, cerebellum development, chromosome organization, circadian behavior, circadian rhythm, determination of adult lifespan, double-strand break repair, embryo development ending in birth or egg hatching, embryonic organ development, entrainment of circadian clock by photoperiod, fibroblast proliferation, gastrulation, glial cell proliferation, glucose catabolic process to lactate via pyruvate, heart development, hematopoietic progenitor cell differentiation, hematopoietic stem cell differentiation, in utero embryonic development, intracellular protein localization, intrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, intrinsic apoptotic signaling pathway in response to hypoxia, mRNA transcription, mitochondrial DNA repair, mitophagy, mitotic G1 DNA damage checkpoint signaling, multicellular organism growth, necroptotic process, negative regulation of DNA metabolic process, negative regulation of DNA replication, negative regulation of DNA-templated transcription, negative regulation of G1 to G0 transition, negative regulation of apoptotic process, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of fibroblast proliferation, negative regulation of gene expression, negative regulation of glial cell proliferation, negative regulation of glucose catabolic process to lactate via pyruvate, negative regulation of helicase activity, negative regulation of miRNA processing, negative regulation of mitophagy, negative regulation of mitotic cell cycle, negative regulation of neuroblast proliferation, negative regulation of pentose-phosphate shunt, negative regulation of proteolysis, negative regulation of reactive oxygen species metabolic process, negative regulation of stem cell proliferation, negative regulation of telomere maintenance via telomerase, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, neuroblast proliferation, neuron apoptotic process, nucleotide-excision repair, oligodendrocyte apoptotic process, oxidative stress-induced premature senescence, positive regulation of DNA-templated transcription, positive regulation of RNA polymerase II transcription preinitiation complex assembly, positive regulation of apoptotic process, positive regulation of cardiac muscle cell apoptotic process, positive regulation of cellular senescence, positive regulation of execution phase of apoptosis, positive regulation of gene expression, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of miRNA transcription, positive regulation of mitochondrial membrane permeability, positive regulation of neuron apoptotic process, positive regulation of programmed necrotic cell death, positive regulation of reactive oxygen species metabolic process, positive regulation of release of cytochrome c from mitochondria, positive regulation of thymocyte apoptotic process, positive regulation of transcription by RNA polymerase II, programmed cell death, protein import into nucleus, protein stabilization, protein tetramerization, protein-containing complex assembly, rRNA transcription, reactive oxygen species metabolic process, regulation of DNA damage response, signal transduction by p53 class mediator, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of cell cycle G2/M phase transition, regulation of cell population proliferation, regulation of cellular senescence, regulation of fibroblast apoptotic process, regulation of intrinsic apoptotic signaling pathway, regulation of intrinsic apoptotic signaling pathway by p53 class mediator, regulation of mitochondrial membrane permeability involved in apoptotic process, regulation of mitotic cell cycle, regulation of neuron apoptotic process, regulation of thymocyte apoptotic process, regulation of tissue remodeling, regulation of transcription by RNA polymerase II, release of cytochrome c from mitochondria, replicative senescence, response to UV, response to X-ray, response to antibiotic, response to gamma radiation, response to ionizing radiation, response to ischemia, response to oxidative stress, response to salt stress, response to xenobiotic stimulus, rhythmic process, signal transduction by p53 class mediator, somitogenesis, stem cell proliferation, thymocyte apoptotic process, transcription initiation-coupled chromatin remodeling, transforming growth factor beta receptor signaling pathway, tumor necrosis factor-mediated signaling pathway, type II interferon-mediated signaling pathway, viral process; MF: 14-3-3 protein binding, ATP-dependent DNA/DNA annealing activity, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, MDM2/MDM4 family protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, TFIID-class transcription factor complex binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, copper ion binding, core promoter sequence-specific DNA binding, disordered domain specific binding, enzyme binding, general transcription initiation factor binding, histone deacetylase binding, histone deacetylase regulator activity, identical protein binding, mRNA 3'-UTR binding, metal ion binding, molecular condensate scaffold activity, molecular function activator activity, p53 binding, promoter-specific chromatin binding, protease binding, protein binding, protein heterodimerization activity, protein phosphatase 2A binding, protein-folding chaperone binding, receptor tyrosine kinase binding, transcription cis-regulatory region binding, transcription coactivator binding, ubiquitin protein ligase binding, zinc ion binding; CC: PML body, centrosome, chromatin, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum, germ cell nucleus, mitochondrial matrix, mitochondrion, nuclear body, nuclear matrix, nucleolus, nucleoplasm, nucleus, protein-containing complex, replication fork, site of double-strand break, transcription regulator complex, transcription repressor complex
Pathways: 16p11.2 proximal deletion syndrome, 22q11.2 copy number variation syndrome, AMP-activated protein kinase (AMPK) signaling, AP-1 transcription factor network, ATM Signaling Pathway, Alzheimer,s disease, Amyotrophic lateral sclerosis (ALS), Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis Modulation and Signaling, Aurora A signaling, BARD1 signaling events, Basal cell carcinoma - Homo sapiens (human), Bladder cancer, Bladder cancer - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, Caloric restriction and aging, Cell cycle, Cell cycle - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Central carbon metabolism in cancer - Homo sapiens (human), Chromosomal and microsatellite instability in colorectal cancer, Chronic myeloid leukemia - Homo sapiens (human), Colorectal cancer - Homo sapiens (human), Copper homeostasis, DNA damage response, DNA damage response (only ATM dependent), Direct p53 effectors, EGFR1, Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Epithelial to mesenchymal transition in colorectal cancer, Epstein-Barr virus infection - Homo sapiens (human), ErbB signaling pathway, Ferroptosis, Ferroptosis - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), Fluoropyrimidine Activity, Folate Metabolism, G1 to S cell cycle control, Gastric Cancer Network 2, Gastric cancer - Homo sapiens (human), Glioblastoma signaling pathways, Glioma - Homo sapiens (human), Glucocorticoid receptor regulatory network, Glycolysis in senescence, Head and Neck Squamous Cell Carcinoma, Hepatitis B - Homo sapiens (human), Hepatitis C - Homo sapiens (human), Hepatitis C and Hepatocellular Carcinoma, Hepatocellular carcinoma - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, IL-18 signaling pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), LKB1 signaling events, Lipid and atherosclerosis - Homo sapiens (human), LncRNA-mediated mechanisms of therapeutic resistance, Longevity regulating pathway - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mammary gland development pathway - Involution (Stage 4 of 4), Measles - Homo sapiens (human), Melanoma, Melanoma - Homo sapiens (human), Metastatic brain tumor, MicroRNA network associated with chronic lymphocytic leukemia, MicroRNAs in cancer - Homo sapiens (human), Mitophagy - animal - Homo sapiens (human), NAD Metabolism in Oncogene-Induced Senescence and Mitochondrial Dysfunction-Associated Senescence, Netrin-UNC5B signaling pathway, Neurotrophin signaling pathway - Homo sapiens (human), Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Oncostatin M Signaling Pathway, Oncostatin_M, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PLK3 signaling events, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways affected in adenoid cystic carcinoma, Pathways in cancer - Homo sapiens (human), Photodynamic therapy-induced HIF-1 survival signaling, Prostate cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, Retinoblastoma gene in cancer, Senescence and Autophagy in Cancer, Shigellosis - Homo sapiens (human), Signaling events mediated by HDAC Class III, Signaling mediated by p38-alpha and p38-beta, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Sphingolipid signaling pathway - Homo sapiens (human), Spinal Cord Injury, TCA cycle in senescence, TGF-beta Signaling Pathway, TGF_beta_Receptor, TP53 network, Thyroid cancer - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, Transcriptional misregulation in cancer - Homo sapiens (human), Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer, Unfolded protein response, Validated targets of C-MYC transcriptional activation, Vinblastine Action Pathway, Vincristine Action Pathway, Vindesine Action Pathway, Vinorelbine Action Pathway, Viral carcinogenesis - Homo sapiens (human), Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, apoptotic signaling in response to dna damage, atm signaling pathway, btg family proteins and cell cycle regulation, cell cycle: g1/s check point, cell cycle: g2/m checkpoint, chaperones modulate interferon signaling pathway, double stranded rna induced gene expression, estrogen responsive protein efp controls cell cycle and breast tumors growth, hypoxia and p53 in the cardiovascular system, miRNA regulation of DNA damage response, miRNA regulation of p53 pathway in prostate cancer, miRNAs involved in DNA damage response, overview of telomerase protein component gene htert transcriptional regulation, p53 pathway, p53 signaling pathway, p53 signaling pathway - Homo sapiens (human), p75(NTR)-mediated signaling, rb tumor suppressor/checkpoint signaling in response to dna damage, regulation of cell cycle progression by plk3, regulation of transcriptional activity by pml, role of brca1 brca2 and atr in cancer susceptibility, telomeres telomerase cellular aging and immortality, tumor suppressor arf inhibits ribosomal biogenesis
UniProt: P04637
Entrez ID: 7157
|
Does Knockout of ACVR2B in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
ACVR2B
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: ACVR2B (activin A receptor type 2B)
Type: protein-coding
Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: BMP signaling pathway, activin receptor signaling pathway, anterior/posterior pattern specification, artery development, blood vessel remodeling, cell surface receptor protein serine/threonine kinase signaling pathway, cellular response to growth factor stimulus, determination of left/right symmetry, developmental process, embryonic foregut morphogenesis, gastrulation with mouth forming second, heart development, insulin secretion, intracellular iron ion homeostasis, kidney development, lung development, lymphangiogenesis, lymphatic endothelial cell differentiation, mesoderm development, negative regulation of adipose tissue development, negative regulation of cold-induced thermogenesis, negative regulation of ossification, negative regulation of transcription by RNA polymerase II, odontogenesis of dentin-containing tooth, organ growth, pancreas development, pattern specification process, positive regulation of activin receptor signaling pathway, positive regulation of bone mineralization, positive regulation of osteoblast differentiation, post-embryonic development, regulation of DNA-templated transcription, regulation of signal transduction, response to glucose, retina vasculature development in camera-type eye, roof of mouth development, signal transduction, skeletal system development, skeletal system morphogenesis, trophoblast cell migration, venous blood vessel development; MF: ATP binding, activin binding, activin receptor activity, activin receptor activity, type II, growth factor binding, kinase activator activity, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, transferase activity, transmembrane receptor protein serine/threonine kinase activity; CC: activin receptor complex, cytoplasm, membrane, plasma membrane, protein-containing complex, receptor complex
Pathways: ALK1 signaling events, BMP Signalling Pathway, Cytokine-cytokine receptor interaction - Homo sapiens (human), Developmental Biology, Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Fluid shear stress and atherosclerosis - Homo sapiens (human), Mesodermal commitment pathway, Regulation of signaling by NODAL, Signal Transduction, Signaling by Activin, Signaling by BMP, Signaling by NODAL, Signaling by TGFB family members, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), TGF-beta signaling pathway - Homo sapiens (human)
UniProt: Q13705
Entrez ID: 93
|
Does Knockout of PCDHA8 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
PCDHA8
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PCDHA8 (protocadherin alpha 8)
Type: protein-coding
Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, nervous system development; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9Y5H6
Entrez ID: 56140
|
Does Knockout of STAMBP in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
STAMBP
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: STAMBP (STAM binding protein)
Type: protein-coding
Summary: Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, hippocampal neuron apoptotic process, mitotic cytokinesis, negative regulation of Ras protein signal transduction, negative regulation of hippocampal neuron apoptotic process, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of cell population proliferation, protein K63-linked deubiquitination, protein deubiquitination, proteolysis; MF: K63-linked deubiquitinase activity, deubiquitinase activity, hydrolase activity, metal ion binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, protein binding, protein domain specific binding; CC: cleavage furrow, cytoplasm, cytosol, early endosome, endosome, extracellular exosome, membrane, nucleoplasm, nucleus, plasma membrane
Pathways: Deubiquitination, EGF-EGFR signaling pathway, EGFR1, Endocytosis - Homo sapiens (human), Internalization of ErbB1, Metabolism of proteins, Metalloprotease DUBs, Post-translational protein modification
UniProt: O95630
Entrez ID: 10617
|
Does Knockout of ZNHIT3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
ZNHIT3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ZNHIT3 (zinc finger HIT-type containing 3)
Type: protein-coding
Summary: Predicted to enable thyroid hormone receptor binding activity. Predicted to be involved in box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA localization. Located in cytoplasm and nucleus. Implicated in PEHO syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: box C/D snoRNP assembly, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), regulation of DNA-templated transcription; MF: metal ion binding, nuclear thyroid hormone receptor binding, protein binding, zinc ion binding; CC: cytoplasm, nucleus, pre-snoRNP complex
Pathways:
UniProt: Q15649
Entrez ID: 9326
|
Does Knockout of POLE in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
POLE
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: POLE (DNA polymerase epsilon, catalytic subunit)
Type: protein-coding
Summary: This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA replication proofreading, DNA synthesis involved in DNA repair, DNA-templated DNA replication, G1/S transition of mitotic cell cycle, base-excision repair, gap-filling, embryonic organ development, leading strand elongation, mitotic cell cycle, nucleotide-excision repair, DNA gap filling; MF: 4 iron, 4 sulfur cluster binding, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, chromatin binding, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, protein binding, single-stranded DNA 3'-5' DNA exonuclease activity, transferase activity, zinc ion binding; CC: epsilon DNA polymerase complex, nucleoplasm, nucleus, plasma membrane
Pathways: Activation of the pre-replicative complex, Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA replication initiation, Dual Incision in GG-NER, Dual incision in TC-NER, G1 to S cell cycle control, G1/S Transition, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Mitotic G1 phase and G1/S transition, Nucleotide Excision Repair, Nucleotide Excision Repair , Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Pyrimidine metabolism, Recognition of DNA damage by PCNA-containing replication complex, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q07864
Entrez ID: 5426
|
Does Knockout of CALD1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
CALD1
|
response to virus
|
Hepatoma Cell Line
|
Gene: CALD1 (caldesmon 1)
Type: protein-coding
Summary: This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin filament bundle assembly, muscle contraction; MF: actin binding, cadherin binding, calmodulin binding, myosin binding, protein binding, tropomyosin binding; CC: actin cap, actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, membrane, myofibril, plasma membrane, stress fiber
Pathways: EGFR1, Muscle contraction, Myometrial relaxation and contraction pathways, Smooth Muscle Contraction, Vascular smooth muscle contraction - Homo sapiens (human)
UniProt: Q05682
Entrez ID: 800
|
Does Knockout of PDCL2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
PDCL2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PDCL2 (phosducin like 2)
Type: protein-coding
Summary: This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: acrosome assembly, cell differentiation, flagellated sperm motility, protein folding, sperm axoneme assembly, sperm flagellum assembly, spermatid development, spermatogenesis; CC: cytoplasm, endoplasmic reticulum
Pathways:
UniProt: Q8N4E4
Entrez ID: 132954
|
Does Knockout of MYH9 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
MYH9
|
cell proliferation
|
Cancer Cell Line
|
Gene: MYH9 (myosin heavy chain 9)
Type: protein-coding
Summary: This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: actin cytoskeleton organization, actin filament-based movement, actomyosin structure organization, angiogenesis, blood vessel endothelial cell migration, cell adhesion, cell morphogenesis, cell motility, cell-cell adhesion, cortical granule exocytosis, cytokinetic process, cytoplasmic actin-based contraction involved in cell motility, cytoskeleton organization, endodermal cell differentiation, establishment of T cell polarity, establishment of meiotic spindle localization, in utero embryonic development, integrin-mediated signaling pathway, leukocyte migration, lysosome localization, meiotic spindle organization, membrane protein ectodomain proteolysis, monocyte differentiation, myoblast fusion, negative regulation of actin filament severing, phagocytosis, engulfment, plasma membrane repair, platelet aggregation, platelet formation, positive regulation of protein processing in phagocytic vesicle, protein transport, regulated exocytosis, regulation of actin filament-based process, regulation of cell shape, regulation of plasma membrane repair, symbiont entry into host cell, uropod organization; MF: ADP binding, ATP binding, RNA binding, actin binding, actin filament binding, cadherin binding, calmodulin binding, cytoskeletal motor activity, identical protein binding, integrin binding, microfilament motor activity, nucleotide binding, protein binding, protein domain specific binding, protein homodimerization activity, protein-membrane adaptor activity, virus receptor activity; CC: COP9 signalosome, Golgi apparatus, actin cytoskeleton, actomyosin, actomyosin contractile ring, adherens junction, brush border, cell cortex, cell leading edge, cell surface, cleavage furrow, cortical cytoskeleton, cortical granule, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, cytosol, extracellular exosome, focal adhesion, immunological synapse, membrane, myosin II complex, myosin II filament, myosin complex, myosin filament, neuromuscular junction, nuclear body, nucleus, plasma membrane, protein-containing complex, ruffle, spindle, stress fiber, supramolecular fiber, uropod
Pathways: Anti-inflammatory response favouring Leishmania parasite infection, Axon guidance, CD163 mediating an anti-inflammatory response, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, EGFR1, EPH-Ephrin signaling, EPHA-mediated growth cone collapse, FCGR3A-mediated phagocytosis, Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania parasite growth and survival, Leishmania phagocytosis, Membrane Trafficking, Nephrotic syndrome, Nervous system development, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), Primary focal segmental glomerulosclerosis (FSGS), RHO GTPase Effectors, RHO GTPases Activate ROCKs, RHO GTPases activate CIT, RHO GTPases activate PAKs, RHO GTPases activate PKNs, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Semaphorin interactions, Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea, Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, VEGFA-VEGFR2 Signaling Pathway, Vascular smooth muscle contraction - Homo sapiens (human), Vesicle-mediated transport
UniProt: P35579
Entrez ID: 4627
|
Does Knockout of KCNJ9 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
KCNJ9
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: KCNJ9 (potassium inwardly rectifying channel subfamily J member 9)
Type: protein-coding
Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion import across plasma membrane, potassium ion transport, regulation of monoatomic ion transmembrane transport, regulation of presynaptic membrane potential; MF: G-protein activated inward rectifier potassium channel activity, inward rectifier potassium channel activity, ligand-gated monoatomic cation channel activity, protein binding; CC: inward rectifier potassium channel complex, membrane, monoatomic ion channel complex, parallel fiber to Purkinje cell synapse, plasma membrane, presynaptic membrane, voltage-gated potassium channel complex
Pathways: Activation of G protein gated Potassium channels, Activation of GABAB receptors, Circadian entrainment - Homo sapiens (human), Dopaminergic synapse - Homo sapiens (human), Estrogen signaling pathway - Homo sapiens (human), G protein gated Potassium channels, GABA B receptor activation, GABA receptor activation, GnRH secretion - Homo sapiens (human), Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Inwardly rectifying K+ channels, Morphine addiction - Homo sapiens (human), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Oxytocin signaling pathway - Homo sapiens (human), Potassium Channels, Retrograde endocannabinoid signaling - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Transmission across Chemical Synapses
UniProt: Q92806
Entrez ID: 3765
|
Does Knockout of ARGLU1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
ARGLU1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: ARGLU1 (arginine and glutamate rich 1)
Type: protein-coding
Summary: Enables cadherin binding activity. Located in cytosol; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, positive regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, cadherin binding, pre-mRNA binding, protein binding, transcription coactivator activity; CC: chromosome, cytosol, mitochondrion, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q9NWB6
Entrez ID: 55082
|
Does Knockout of DPY19L3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
DPY19L3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DPY19L3 (dpy-19 like C-mannosyltransferase 3)
Type: protein-coding
Summary: Predicted to enable mannosyltransferase activity. Predicted to be involved in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan. Predicted to be integral component of membrane. Predicted to be active in nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: glycosyltransferase activity, mannosyltransferase activity, protein binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q6ZPD9
Entrez ID: 147991
|
Does Knockout of NSMCE2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
NSMCE2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: NSMCE2 (NSE2 SUMO ligase component of SMC5/6 complex)
Type: protein-coding
Summary: This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell division, cellular senescence, chromatin looping, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, positive regulation of maintenance of mitotic sister chromatid cohesion, positive regulation of mitotic metaphase/anaphase transition, protein sumoylation, regulation of telomere maintenance, telomere maintenance via recombination; MF: SUMO ligase activity, SUMO transferase activity, metal ion binding, protein binding, transferase activity, zinc ion binding; CC: PML body, Smc5-Smc6 complex, chromosome, chromosome, telomeric region, nuclear body, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q96MF7
Entrez ID: 286053
|
Does Activation of CDH24 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
CDH24
|
protein/peptide accumulation
|
T cell
|
Gene: CDH24 (cadherin 24)
Type: protein-coding
Summary: Enables several functions, including alpha-catenin binding activity; beta-catenin binding activity; and delta-catenin binding activity. Acts upstream of or within cell-cell adhesion. Located in cell-cell junction. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: adherens junction organization, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, homophilic cell adhesion via plasma membrane adhesion molecules; MF: alpha-catenin binding, beta-catenin binding, cadherin binding, calcium ion binding, delta-catenin binding, metal ion binding; CC: adherens junction, catenin complex, cell-cell junction, membrane, plasma membrane
Pathways: Adherens junctions interactions, CDH11 homotypic and heterotypic interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Hippo-Merlin Signaling Dysregulation, Pathways Regulating Hippo Signaling, Regulation of CDH11 Expression and Function, Regulation of CDH11 function, Regulation of Expression and Function of Type II Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q86UP0
Entrez ID: 64403
|
Does Knockout of MRPS5 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
MRPS5
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: MRPS5 (mitochondrial ribosomal protein S5)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: P82675
Entrez ID: 64969
|
Does Knockout of DNAJC24 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
DNAJC24
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
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Gene: DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24)
Type: protein-coding
Summary: Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: positive regulation of ATP-dependent activity, protein folding, protein histidyl modification to diphthamide; MF: ATPase activator activity, ferrous iron binding, metal ion binding, zinc ion binding; CC: actin cytoskeleton, cytoplasm, cytoskeleton
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Synthesis of diphthamide-EEF2
UniProt: Q6P3W2
Entrez ID: 120526
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Does Knockout of CCDC34 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
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| 1,397
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Knockout
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CCDC34
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response to chemicals
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Chronic Myeloid Leukemia Cell Line
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Gene: CCDC34 (coiled-coil domain containing 34)
Type: protein-coding
Summary: Involved in spermatogenesis. Located in sperm midpiece. Implicated in spermatogenic failure 76. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: spermatogenesis; CC: cell projection, cilium, motile cilium, sperm midpiece
Pathways:
UniProt: Q96HJ3
Entrez ID: 91057
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