prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of EFR3B in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | EFR3B | cell proliferation | Medulloblastoma Cell Line | Gene: EFR3B (EFR3 homolog B)
Type: protein-coding
Summary: Involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Located in actin cytoskeleton; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology... |
Does Knockout of GOLT1A in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | GOLT1A | cell proliferation | Breast Cancer Cell Line | Gene: GOLT1A (golgi transport 1A)
Type: protein-coding
Summary: Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus subcompartment; endoplasmic reticulum; and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Gen... |
Does Knockout of CST11 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | CST11 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: CST11 (cystatin 11)
Type: protein-coding
Summary: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inh... |
Does Knockout of PRKRA in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | PRKRA | cell proliferation | Bladder Carcinoma | Gene: PRKRA (protein activator of interferon induced protein kinase EIF2AK2)
Type: protein-coding
Summary: This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystoni... |
Does Knockout of DEFB104B in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | DEFB104B | cell proliferation | Cancer Cell Line | Gene: DEFB104B (defensin beta 104B)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins.... |
Does Knockout of C3orf62 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | C3orf62 | cell proliferation | Hepatoma Cell Line | Gene: C3orf62 (chromosome 3 open reading frame 62)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, spermatogenesis
Pathways:
UniProt: Q6ZUJ4
Entrez ID: 375341 |
Does Knockout of CDK14 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | CDK14 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: CDK14 (cyclin dependent kinase 14)
Type: protein-coding
Summary: PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
Gene Ontology: BP: G2/M transition of mitotic cell cycle, Wnt signaling pathway, c... |
Does Knockout of PSMB6 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | PSMB6 | cell proliferation | Melanoma Cell Line | Gene: PSMB6 (proteasome 20S subunit beta 6)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rin... |
Does Knockout of WDR73 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | WDR73 | cell proliferation | Endometrial Cancer Cell Line | Gene: WDR73 (WD repeat domain 73)
Type: protein-coding
Summary: The protein encoded by this gene is thought to contain multiple WD40 repeats. WD40 repeats are motifs that contain 40-60 amino acids, and usually end with Trp-Asp (WD). This protein is found in the cytoplasm during interphase, but accumulat... |
Does Knockout of ALG11 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | ALG11 | cell proliferation | Glioblastoma Cell Line | Gene: ALG11 (ALG11 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue f... |
Does Knockout of LRRC73 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | LRRC73 | cell proliferation | Medulloblastoma Cell Line | Gene: LRRC73 (leucine rich repeat containing 73)
Type: protein-coding
Summary: leucine rich repeat containing 73
Gene Ontology:
Pathways:
UniProt: Q5JTD7
Entrez ID: 221424 |
Does Knockout of BMP10 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | BMP10 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: BMP10 (bone morphogenetic protein 10)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcripti... |
Does Knockout of ZNF322 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | ZNF322 | cell proliferation | Endometrial Cancer Cell Line | Gene: ZNF322 (zinc finger protein 322)
Type: protein-coding
Summary: ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008].
... |
Does Knockout of B9D1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | B9D1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: B9D1 (B9 domain containing 1)
Type: protein-coding
Summary: This gene encodes a B9 domain-containing protein, one of several that are involved in ciliogenesis. Alterations in expression of this gene have been found in a family with Meckel syndrome. Meckel syndrome has been associated with at least... |
Does Knockout of WDTC1 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | WDTC1 | cell proliferation | Breast Cancer Cell Line | Gene: WDTC1 (WD and tetratricopeptide repeats 1)
Type: protein-coding
Summary: Predicted to enable enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to act upstream ... |
Does Knockout of UGT2A1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | UGT2A1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: UGT2A1 (UDP glucuronosyltransferase family 2 member A1 complex locus)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiot... |
Does Knockout of OST4 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | OST4 | cell proliferation | Medulloblastoma Cell Line | Gene: OST4 (oligosaccharyltransferase complex subunit 4, non-catalytic)
Type: protein-coding
Summary: Involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein N-linked gl... |
Does Knockout of RCC1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | RCC1 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: RCC1 (regulator of chromosome condensation 1)
Type: protein-coding
Summary: Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in several processes, including G1/S transition of mitoti... |
Does Knockout of C14orf93 in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | C14orf93 | cell proliferation | Prostate Cancer Cell Line | Gene: C14orf93 (chromosome 14 open reading frame 93)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to act upstream of or within anatomical structure development; cell differentiation; and positive regulation of gene expression. Predicted to be located in extracellular region. [pr... |
Does Knockout of FAM185A in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | FAM185A | cell proliferation | Cancer Cell Line | Gene: FAM185A (family with sequence similarity 185 member A)
Type: protein-coding
Summary: Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q8N0U4
Entrez ID: 222234 |
Does Knockout of RPRD2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | RPRD2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: RPRD2 (regulation of nuclear pre-mRNA domain containing 2)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of RANBP3 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | RANBP3 | cell proliferation | Cancer Cell Line | Gene: RANBP3 (RAN binding protein 3)
Type: protein-coding
Summary: This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different... |
Does Knockout of LONP1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | LONP1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: LONP1 (lon peptidase 1, mitochondrial)
Type: protein-coding
Summary: This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mito... |
Does Knockout of TEX36 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | TEX36 | cell proliferation | Glioblastoma Cell Line | Gene: TEX36 (testis expressed 36)
Type: protein-coding
Summary: testis expressed 36
Gene Ontology:
Pathways:
UniProt: Q5VZQ5
Entrez ID: 387718 |
Does Knockout of CAVIN1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | CAVIN1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: CAVIN1 (caveolae associated protein 1)
Type: protein-coding
Summary: This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of ... |
Does Knockout of STMN3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | STMN3 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: STMN3 (stathmin 3)
Type: protein-coding
Summary: This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and bet... |
Does Knockout of HFE in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | HFE | response to chemicals | Melanoma Cell Line | Gene: HFE (homeostatic iron regulator)
Type: protein-coding
Summary: The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating t... |
Does Knockout of PGM2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | PGM2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: PGM2 (phosphoglucomutase 2)
Type: protein-coding
Summary: Enables phosphopentomutase activity. Predicted to be involved in carbohydrate metabolic process and deoxyribose phosphate catabolic process. Predicted to act upstream of or within glucose metabolic process. Located in extracellular exosome.... |
Does Knockout of PXDN in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | PXDN | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: PXDN (peroxidasin)
Type: protein-coding
Summary: This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations... |
Does Knockout of MATR3 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | MATR3 | cell proliferation | Prostate Cancer Cell Line | Gene: MATR3 (matrin 3)
Type: protein-coding
Summary: This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced tran... |
Does Knockout of NLRC3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | NLRC3 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: NLRC3 (NLR family CARD domain containing 3)
Type: protein-coding
Summary: This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper traffic... |
Does Knockout of DISP2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | DISP2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: DISP2 (dispatched RND transporter family member 2)
Type: protein-coding
Summary: This gene is one of two human homologs of a segment-polarity gene known as dispatched identified in Drosophila. The product of this gene may be required for normal Hedgehog (Hh) signaling during embryonic pattern form... |
Does Knockout of SLC35F3 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | SLC35F3 | cell proliferation | Colonic Cancer Cell Line | Gene: SLC35F3 (solute carrier family 35 member F3)
Type: protein-coding
Summary: Involved in thiamine transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: thiamine transport
Pathways:
UniProt: Q8IY5... |
Does Knockout of CNTLN in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | CNTLN | cell proliferation | Multiple Myeloma Cell Line | Gene: CNTLN (centlein)
Type: protein-coding
Summary: Enables protein domain specific binding activity; protein kinase binding activity; and protein-macromolecule adaptor activity. Involved in centriole-centriole cohesion and protein localization to organelle. Located in cytosol; microtubule organizing c... |
Does Knockout of AMER2 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | AMER2 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: AMER2 (APC membrane recruitment protein 2)
Type: protein-coding
Summary: Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gen... |
Does Knockout of DCAF13 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 1,510 | Knockout | DCAF13 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: DCAF13 (DDB1 and CUL4 associated factor 13)
Type: protein-coding
Summary: Enables estrogen receptor binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in several cellular components, including centrosome; ... |
Does Knockout of SNTB2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | SNTB2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: SNTB2 (syntrophin beta 2)
Type: protein-coding
Summary: Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The prote... |
Does Knockout of PNMA5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | PNMA5 | cell proliferation | Colonic Cancer Cell Line | Gene: PNMA5 (PNMA family member 5)
Type: protein-coding
Summary: This gene encodes a member of the paraneoplastic Ma antigen protein family. These proteins have been implicated in the development of paraneoplastic disorders resulting from an immune response directed against them. Paraneoplastic disorder... |
Does Knockout of SLC4A7 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | SLC4A7 | cell proliferation | Multiple Myeloma Cell Line | Gene: SLC4A7 (solute carrier family 4 member 7)
Type: protein-coding
Summary: This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded prot... |
Does Knockout of MKS1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | MKS1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: MKS1 (MKS transition zone complex subunit 1)
Type: protein-coding
Summary: The protein encoded by this gene localizes to the basal body and is required for formation of the primary cilium in ciliated epithelial cells. Mutations in this gene result in Meckel syndrome type 1 and in Bardet-Biedl synd... |
Does Knockout of HIRA in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | HIRA | cell proliferation | Colonic Cancer Cell Line | Gene: HIRA (histone cell cycle regulator)
Type: protein-coding
Summary: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin.... |
Does Knockout of RPL32 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | RPL32 | cell proliferation | Colonic Cancer Cell Line | Gene: RPL32 (ribosomal protein L32)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of HTATSF1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | HTATSF1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: HTATSF1 (HIV-1 Tat specific factor 1)
Type: protein-coding
Summary: The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function... |
Does Knockout of VHL in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | VHL | cell proliferation | Prostate Cancer Cell Line | Gene: VHL (von Hippel-Lindau tumor suppressor)
Type: protein-coding
Summary: This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in th... |
Does Knockout of WRAP73 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | WRAP73 | cell proliferation | Medulloblastoma Cell Line | Gene: WRAP73 (WD repeat containing, antisense to TP73)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation o... |
Does Knockout of MIR6869 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | MIR6869 | response to chemicals | Glioblastoma Cell Line | Gene: MIR6869 (microRNA 6869)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of LRRC56 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | LRRC56 | cell proliferation | Colonic Cancer Cell Line | Gene: LRRC56 (leucine rich repeat containing 56)
Type: protein-coding
Summary: Predicted to be involved in cell projection organization. Predicted to be located in cilium. Implicated in primary ciliary dyskinesia 39. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell p... |
Does Knockout of SEC13 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | SEC13 | cell proliferation | Multiple Myeloma Cell Line | Gene: SEC13 (SEC13 homolog, nuclear pore and COPII component)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, whi... |
Does Knockout of CACNA2D4 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | CACNA2D4 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: CACNA2D4 (calcium voltage-gated channel auxiliary subunit alpha2delta 4)
Type: protein-coding
Summary: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon ... |
Does Knockout of PGA3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | PGA3 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: PGA3 (pepsinogen A3)
Type: protein-coding
Summary: This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form... |
Does Knockout of ESPL1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | ESPL1 | cell proliferation | Colonic Cancer Cell Line | Gene: ESPL1 (extra spindle pole bodies like 1, separase)
Type: protein-coding
Summary: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via disti... |
Does Knockout of BRAP in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | BRAP | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: BRAP (BRCA1 associated protein)
Type: protein-coding
Summary: The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear... |
Does Knockout of GCK in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | GCK | cell proliferation | Endometrial Cancer Cell Line | Gene: GCK (glucokinase)
Type: protein-coding
Summary: This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibi... |
Does Knockout of GLUD1 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | GLUD1 | cell proliferation | Astrocytoma Cell Line | Gene: GLUD1 (glutamate dehydrogenase 1)
Type: protein-coding
Summary: This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-ind... |
Does Knockout of ATP6V1G2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | ATP6V1G2 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: ATP6V1G2 (ATPase H+ transporting V1 subunit G2)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such int... |
Does Knockout of AADACL3 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | AADACL3 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: AADACL3 (arylacetamide deacetylase like 3)
Type: protein-coding
Summary: Predicted to enable hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: carboxylic ester hydrolase activity, hydrolase activity
... |
Does Knockout of SIRT6 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | SIRT6 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SIRT6 (sirtuin 6)
Type: protein-coding
Summary: This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transf... |
Does Knockout of SEC14L5 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | SEC14L5 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: SEC14L5 (SEC14 like lipid binding 5)
Type: protein-coding
Summary: Predicted to be located in mitochondrial intermembrane space. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: O43304
E... |
Does Knockout of EIF3E in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | EIF3E | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: EIF3E (eukaryotic translation initiation factor 3 subunit E)
Type: protein-coding
Summary: Enables protein N-terminus binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; regulation of gene expression; and translational ... |
Does Knockout of NRIP3 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | NRIP3 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: NRIP3 (nuclear receptor interacting protein 3)
Type: protein-coding
Summary: Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: aspartic-type endopeptidase activity, pro... |
Does Knockout of CLDN16 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | CLDN16 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: CLDN16 (claudin 16)
Type: protein-coding
Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular ... |
Does Knockout of UQCRH in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | UQCRH | cell proliferation | Glioblastoma Cell Line | Gene: UQCRH (ubiquinol-cytochrome c reductase hinge protein)
Type: protein-coding
Summary: Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. [provided by Alliance of Genome Res... |
Does Knockout of PMAIP1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | PMAIP1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1)
Type: protein-coding
Summary: This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response... |
Does Knockout of CDH4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | CDH4 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: CDH4 (cadherin 4)
Type: protein-coding
Summary: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic ta... |
Does Knockout of PRSS3 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | PRSS3 | cell proliferation | Colorectal Cancer Cell Line | Gene: PRSS3 (serine protease 3)
Type: protein-coding
Summary: This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the car... |
Does Knockout of HNRNPUL1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | HNRNPUL1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U like 1)
Type: protein-coding
Summary: This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an importan... |
Does Knockout of ZNF594 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | ZNF594 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: ZNF594 (zinc finger protein 594)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by... |
Does Knockout of PSMD12 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | PSMD12 | cell proliferation | Glioblastoma Cell Line | Gene: PSMD12 (proteasome 26S subunit, non-ATPase 12)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings ... |
Does Knockout of CXorf66 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | CXorf66 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: CXorf66 (chromosome X open reading frame 66)
Type: protein-coding
Summary: The protein encoded by this gene is predicted to be a type I membrane protein, however, its exact function is not known. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt: Q5JRM2
... |
Does Knockout of BCL9L in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | BCL9L | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: BCL9L (BCL9 like)
Type: protein-coding
Summary: Enables beta-catenin binding activity. Involved in several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; and positive regulation of... |
Does Knockout of TXNDC15 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | TXNDC15 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: TXNDC15 (thioredoxin domain containing 15)
Type: protein-coding
Summary: This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. [provided ... |
Does Knockout of GGTLC2 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | GGTLC2 | cell proliferation | Bladder Carcinoma | Gene: GGTLC2 (gamma-glutamyltransferase light chain 2)
Type: protein-coding
Summary: This gene encodes a protein related to enzymes that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides. Unlike similar proteins, the encoded protein contains only the light chain portion and may not ... |
Does Knockout of CYCS in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | CYCS | cell proliferation | Neuroblastoma Cell Line | Gene: CYCS (cytochrome c, somatic)
Type: protein-coding
Summary: This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytoc... |
Does Knockout of GID8 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | GID8 | cell proliferation | Monocytic Leukemia Cell Line | Gene: GID8 (GID complex subunit 8 homolog)
Type: protein-coding
Summary: Predicted to enable protein homodimerization activity. Involved in positive regulation of canonical Wnt signaling pathway and positive regulation of cell population proliferation. Located in cell junction; cytosol; and nucleoplasm.... |
Does Activation of IRAK3 in T cell causally result in protein/peptide accumulation? | 1 | 2,426 | Activation | IRAK3 | protein/peptide accumulation | T cell | Gene: IRAK3 (interleukin 1 receptor associated kinase 3)
Type: protein-coding
Summary: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primaril... |
Does Knockout of ZNF578 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | ZNF578 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: ZNF578 (zinc finger protein 578)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of ARL13B in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | ARL13B | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: ARL13B (ARF like GTPase 13B)
Type: protein-coding
Summary: This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a... |
Does Knockout of GEMIN5 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | GEMIN5 | cell proliferation | Monocytic Leukemia Cell Line | Gene: GEMIN5 (gem nuclear organelle associated protein 5)
Type: protein-coding
Summary: This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribo... |
Does Knockout of RBPJ in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | RBPJ | response to virus | Cervical Adenocarcinoma Cell Line | Gene: RBPJ (recombination signal binding protein for immunoglobulin kappa J region)
Type: protein-coding
Summary: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an acti... |
Does Knockout of TTC27 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | TTC27 | cell proliferation | Prostate Cancer Cell Line | Gene: TTC27 (tetratricopeptide repeat domain 27)
Type: protein-coding
Summary: tetratricopeptide repeat domain 27
Gene Ontology:
Pathways:
UniProt: Q6P3X3
Entrez ID: 55622 |
Does Knockout of RPL3 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | RPL3 | cell proliferation | Glioblastoma Cell Line | Gene: RPL3 (ribosomal protein L3)
Type: protein-coding
Summary: Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a... |
Does Knockout of LENG1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | LENG1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: LENG1 (leukocyte receptor cluster member 1)
Type: protein-coding
Summary: Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA... |
Does Knockout of HAS2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | HAS2 | cell proliferation | Colonic Cancer Cell Line | Gene: HAS2 (hyaluronan synthase 2)
Type: protein-coding
Summary: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating gluc... |
Does Knockout of TP53 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | TP53 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: TP53 (tumor protein p53)
Type: protein-coding
Summary: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing ce... |
Does Knockout of ACVR2B in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | ACVR2B | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: ACVR2B (activin A receptor type 2B)
Type: protein-coding
Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor... |
Does Knockout of PCDHA8 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | PCDHA8 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PCDHA8 (protocadherin alpha 8)
Type: protein-coding
Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clus... |
Does Knockout of STAMBP in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | STAMBP | cell proliferation | Mammary Gland Tumor Cell Line | Gene: STAMBP (STAM binding protein)
Type: protein-coding
Summary: Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The pr... |
Does Knockout of ZNHIT3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | ZNHIT3 | cell proliferation | Endometrial Cancer Cell Line | Gene: ZNHIT3 (zinc finger HIT-type containing 3)
Type: protein-coding
Summary: Predicted to enable thyroid hormone receptor binding activity. Predicted to be involved in box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA localiza... |
Does Knockout of POLE in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | POLE | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: POLE (DNA polymerase epsilon, catalytic subunit)
Type: protein-coding
Summary: This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial d... |
Does Knockout of CALD1 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | CALD1 | response to virus | Hepatoma Cell Line | Gene: CALD1 (caldesmon 1)
Type: protein-coding
Summary: This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, ... |
Does Knockout of PDCL2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | PDCL2 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: PDCL2 (phosducin like 2)
Type: protein-coding
Summary: This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family ha... |
Does Knockout of MYH9 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | MYH9 | cell proliferation | Cancer Cell Line | Gene: MYH9 (myosin heavy chain 9)
Type: protein-coding
Summary: This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-l... |
Does Knockout of KCNJ9 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | KCNJ9 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: KCNJ9 (potassium inwardly rectifying channel subfamily J member 9)
Type: protein-coding
Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rect... |
Does Knockout of ARGLU1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | ARGLU1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: ARGLU1 (arginine and glutamate rich 1)
Type: protein-coding
Summary: Enables cadherin binding activity. Located in cytosol; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, positive regulation of DNA-tem... |
Does Knockout of DPY19L3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | DPY19L3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: DPY19L3 (dpy-19 like C-mannosyltransferase 3)
Type: protein-coding
Summary: Predicted to enable mannosyltransferase activity. Predicted to be involved in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan. Predicted to be integral component of membrane. Predicted to be active in nuc... |
Does Knockout of NSMCE2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | NSMCE2 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: NSMCE2 (NSE2 SUMO ligase component of SMC5/6 complex)
Type: protein-coding
Summary: This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segre... |
Does Activation of CDH24 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | CDH24 | protein/peptide accumulation | T cell | Gene: CDH24 (cadherin 24)
Type: protein-coding
Summary: Enables several functions, including alpha-catenin binding activity; beta-catenin binding activity; and delta-catenin binding activity. Acts upstream of or within cell-cell adhesion. Located in cell-cell junction. [provided by Alliance of Genome Re... |
Does Knockout of MRPS5 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | MRPS5 | cell proliferation | Glioblastoma Cell Line | Gene: MRPS5 (mitochondrial ribosomal protein S5)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. T... |
Does Knockout of DNAJC24 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | DNAJC24 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24)
Type: protein-coding
Summary: Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the ... |
Does Knockout of CCDC34 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | CCDC34 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: CCDC34 (coiled-coil domain containing 34)
Type: protein-coding
Summary: Involved in spermatogenesis. Located in sperm midpiece. Implicated in spermatogenic failure 76. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: spermatogenesis; CC: cell projection, cilium, mot... |
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