prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of ACTR10 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | ACTR10 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: ACTR10 (actin related protein 10)
Type: protein-coding
Summary: Predicted to be involved in retrograde axonal transport of mitochondrion. Predicted to be located in cytosol; extracellular region; and secretory granule. Predicted to be part of dynactin complex. [provided by Alliance of Genome Resou... |
Does Knockout of MAN2A1 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | MAN2A1 | cell proliferation | Astrocytoma Cell Line | Gene: MAN2A1 (mannosidase alpha class 2A member 1)
Type: protein-coding
Summary: This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene ... |
Does Knockout of CDC45 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | CDC45 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CDC45 (cell division cycle 45)
Type: protein-coding
Summary: The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein comp... |
Does Knockout of KHDC1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | KHDC1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: KHDC1 (KH domain containing 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and poly(U) RNA binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be integral component of ... |
Does Knockout of LTB4R2 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | LTB4R2 | cell proliferation | Medulloblastoma Cell Line | Gene: LTB4R2 (leukotriene B4 receptor 2)
Type: protein-coding
Summary: Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within kerati... |
Does Knockout of POT1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | POT1 | cell proliferation | Glioblastoma Cell Line | Gene: POT1 (protection of telomeres 1)
Type: protein-coding
Summary: This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, reg... |
Does Knockout of TCAF1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | TCAF1 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: TCAF1 (TRPM8 channel associated factor 1)
Type: protein-coding
Summary: Enables transmembrane transporter binding activity. Involved in negative regulation of cell migration; positive regulation of anion channel activity; and positive regulation of protein targeting to membrane. Located in plasma ... |
Does Activation of WFDC12 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | WFDC12 | protein/peptide accumulation | T cell | Gene: WFDC12 (WAP four-disulfide core domain 12)
Type: protein-coding
Summary: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as ... |
Does Knockout of SACM1L in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | SACM1L | cell proliferation | Cancer Cell Line | Gene: SACM1L (SAC1 like phosphatidylinositide phosphatase)
Type: protein-coding
Summary: This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol... |
Does Knockout of INTS5 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | INTS5 | cell proliferation | Endometrial Cancer Cell Line | Gene: INTS5 (integrator complex subunit 5)
Type: protein-coding
Summary: The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processi... |
Does Knockout of UTP15 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | UTP15 | cell proliferation | Monocytic Leukemia Cell Line | Gene: UTP15 (UTP15 small subunit processome component)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in endoplasmic reticulum and fibrillar center. [provided by Alliance... |
Does Knockout of CCNF in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | CCNF | cell proliferation | Cancer Cell Line | Gene: CCNF (cyclin F)
Type: protein-coding
Summary: This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is chara... |
Does Knockout of WBP11 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | WBP11 | cell proliferation | Medulloblastoma Cell Line | Gene: WBP11 (WW domain binding protein 11)
Type: protein-coding
Summary: This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains ... |
Does Knockout of ADM2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | ADM2 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: ADM2 (adrenomedullin 2)
Type: protein-coding
Summary: This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food ... |
Does Knockout of ZNF792 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | ZNF792 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ZNF792 (zinc finger protein 792)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: B... |
Does Knockout of KIF15 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | KIF15 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: KIF15 (kinesin family member 15)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity and microtubule motor activity. Predicted to be involved in microtubule-based movement. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: ... |
Does Activation of ANKRD13A in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | ANKRD13A | protein/peptide accumulation | T cell | Gene: ANKRD13A (ankyrin repeat domain 13A)
Type: protein-coding
Summary: Enables ubiquitin-dependent protein binding activity. Involved in negative regulation of protein localization to endosome and negative regulation of receptor internalization. Located in late endosome; perinuclear region of cytoplas... |
Does Knockout of UQCRC2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | UQCRC2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: UQCRC2 (ubiquinol-cytochrome c reductase core protein 2)
Type: protein-coding
Summary: The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondria... |
Does Knockout of EBNA1BP2 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | EBNA1BP2 | cell proliferation | Medulloblastoma Cell Line | Gene: EBNA1BP2 (EBNA1 binding protein 2)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: r... |
Does Knockout of ZCWPW2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | ZCWPW2 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: ZCWPW2 (zinc finger CW-type and PWWP domain containing 2)
Type: protein-coding
Summary: Enables methylated histone binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: histone H3K4me3 reader activity, metal ion bindin... |
Does Knockout of ASPHD2 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | ASPHD2 | response to virus | Hepatoma Cell Line | Gene: ASPHD2 (aspartate beta-hydroxylase domain containing 2)
Type: protein-coding
Summary: Predicted to enable dioxygenase activity and metal ion binding activity. Predicted to be involved in peptidyl-amino acid modification. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Activation of NUP188 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | NUP188 | protein/peptide accumulation | T cell | Gene: NUP188 (nucleoporin 188)
Type: protein-coding
Summary: The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively kno... |
Does Knockout of TMSB10 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | TMSB10 | cell proliferation | Gastric Cancer Cell Line | Gene: TMSB10 (thymosin beta 10)
Type: protein-coding
Summary: Predicted to enable actin monomer binding activity. Predicted to be involved in regulation of cell migration and sequestering of actin monomers. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Allian... |
Does Knockout of ARGLU1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | ARGLU1 | cell proliferation | Colonic Cancer Cell Line | Gene: ARGLU1 (arginine and glutamate rich 1)
Type: protein-coding
Summary: Enables cadherin binding activity. Located in cytosol; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, positive regulation of DNA-tem... |
Does Knockout of FBXO30 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | FBXO30 | cell proliferation | Colonic Cancer Cell Line | Gene: FBXO30 (F-box protein 30)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1... |
Does Knockout of ADCK2 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | ADCK2 | cell proliferation | Medulloblastoma Cell Line | Gene: ADCK2 (aarF domain containing kinase 2)
Type: protein-coding
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resource... |
Does Inhibition of MRPL19 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,184 | Inhibition | MRPL19 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: MRPL19 (mitochondrial ribosomal protein L19)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of GEMIN4 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | GEMIN4 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: GEMIN4 (gem nuclear organelle associated protein 4)
Type: protein-coding
Summary: The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytopl... |
Does Knockout of ZNF300 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | ZNF300 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: ZNF300 (zinc finger protein 300)
Type: protein-coding
Summary: The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found ... |
Does Knockout of MLST8 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | MLST8 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: MLST8 (MTOR associated protein MLST8)
Type: protein-coding
Summary: Enables protein serine/threonine kinase activator activity. Involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided b... |
Does Knockout of FAM32A in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | FAM32A | cell proliferation | Ewing's Sarcoma Cell Line | Gene: FAM32A (family with sequence similarity 32 member A)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in apoptotic process. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protei... |
Does Knockout of AGBL4 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | AGBL4 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: AGBL4 (AGBL carboxypeptidase 4)
Type: protein-coding
Summary: Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Predicted to be involved in C-terminal protein deglutamylation; defense response to virus; and protein side chain deglutamylation. Predicted to act upstr... |
Does Knockout of FANCD2OS in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | FANCD2OS | cell proliferation | Neuroblastoma Cell Line | Gene: FANCD2OS (FANCD2 opposite strand)
Type: protein-coding
Summary: This gene encodes a conserved protein of unknown function. [provided by RefSeq, Jan 2013].
Gene Ontology:
Pathways:
UniProt: Q96PS1
Entrez ID: 115795 |
Does Knockout of TOMM20 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | TOMM20 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: TOMM20 (translocase of outer mitochondrial membrane 20)
Type: protein-coding
Summary: Enables protein-transporting ATPase activity and unfolded protein binding activity. Involved in protein targeting to mitochondrion. Located in mitochondria-associated endoplasmic reticulum membrane and mitochondr... |
Does Knockout of PCDH20 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | PCDH20 | cell proliferation | Colorectal Cancer Cell Line | Gene: PCDH20 (protocadherin 20)
Type: protein-coding
Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of th... |
Does Knockout of UQCRH in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | UQCRH | cell proliferation | Bladder Carcinoma | Gene: UQCRH (ubiquinol-cytochrome c reductase hinge protein)
Type: protein-coding
Summary: Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. [provided by Alliance of Genome Res... |
Does Knockout of GPR61 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | GPR61 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: GPR61 (G protein-coupled receptor 61)
Type: protein-coding
Summary: This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is m... |
Does Knockout of CSE1L in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | CSE1L | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: CSE1L (chromosome segregation 1 like)
Type: protein-coding
Summary: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore com... |
Does Knockout of DIS3 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | DIS3 | cell proliferation | Ovarian Cancer Cell Line | Gene: DIS3 (DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease)
Type: protein-coding
Summary: Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleop... |
Does Knockout of GPSM2 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | GPSM2 | cell proliferation | Hepatoma Cell Line | Gene: GPSM2 (G protein signaling modulator 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal... |
Does Knockout of MAP3K3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | MAP3K3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: MAP3K3 (mitogen-activated protein kinase kinase kinase 3)
Type: protein-coding
Summary: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast... |
Does Knockout of BIVM in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | BIVM | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: BIVM (basic, immunoglobulin-like variable motif containing)
Type: protein-coding
Summary: Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA endonuclease activity, protein binding, single-stranded DNA binding; CC: cytoplasm, extrace... |
Does Knockout of LAMP5 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | LAMP5 | cell proliferation | Hepatoma Cell Line | Gene: LAMP5 (lysosomal associated membrane protein family member 5)
Type: protein-coding
Summary: Predicted to be involved in establishment of protein localization to organelle. Located in endoplasmic reticulum-Golgi intermediate compartment membrane; endosome membrane; and plasma membrane. [provided by... |
Does Knockout of CTR9 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | CTR9 | cell proliferation | Renal Cancer Cell Line | Gene: CTR9 (CTR9 component of Paf1/RNA polymerase II complex)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the PAF1 complex, which associates with RNA polymerase II and functions in transcriptional regulation and elongation. This complex also plays a role in the modif... |
Does Knockout of NUDT4 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | NUDT4 | cell proliferation | Multiple Myeloma Cell Line | Gene: NUDT4 (nudix hydrolase 4)
Type: protein-coding
Summary: The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. ... |
Does Knockout of PIK3C2A in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | PIK3C2A | cell proliferation | Medulloblastoma Cell Line | Gene: PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transform... |
Does Knockout of CCNA2 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | CCNA2 | cell proliferation | Endometrial Cancer Cell Line | Gene: CCNA2 (cyclin A2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [pr... |
Does Knockout of LRRN3 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | LRRN3 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: LRRN3 (leucine rich repeat neuronal 3)
Type: protein-coding
Summary: Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Geno... |
Does Activation of FBLN5 in Mammary Epithelial Cell Line causally result in cell proliferation? | 0 | 2,280 | Activation | FBLN5 | cell proliferation | Mammary Epithelial Cell Line | Gene: FBLN5 (fibulin 5)
Type: protein-coding
Summary: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It ... |
Does Knockout of CPNE5 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | CPNE5 | response to virus | Hepatoma Cell Line | Gene: CPNE5 (copine 5)
Type: protein-coding
Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and a... |
Does Knockout of INS in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | INS | cell proliferation | Monocytic Leukemia Cell Line | Gene: INS (insulin)
Type: protein-coding
Summary: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A ... |
Does Knockout of PPM1G in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | PPM1G | cell proliferation | Monocytic Leukemia Cell Line | Gene: PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to ... |
Does Knockout of SUPT4H1 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | SUPT4H1 | cell proliferation | T-lymphoma cell line | Gene: SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit)
Type: protein-coding
Summary: This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymer... |
Does Knockout of XRN1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | XRN1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: XRN1 (5'-3' exoribonuclease 1)
Type: protein-coding
Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA ... |
Does Knockout of HIC2 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | HIC2 | response to chemicals | Monocytic Leukemia Cell Line | Gene: HIC2 (HIC ZBTB transcriptional repressor 2)
Type: protein-coding
Summary: Enables protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: ... |
Does Knockout of UBE2G2 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | UBE2G2 | cell proliferation | Gastric Cancer Cell Line | Gene: UBE2G2 (ubiquitin conjugating enzyme E2 G2)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating e... |
Does Knockout of GUK1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | GUK1 | cell proliferation | Bladder Carcinoma | Gene: GUK1 (guanylate kinase 1)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemot... |
Does Knockout of MGAT5 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | MGAT5 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked olig... |
Does Knockout of NTSR2 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | NTSR2 | response to virus | Huh-7 Cell | Gene: NTSR2 (neurotensin receptor 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin ... |
Does Knockout of RPE in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | RPE | cell proliferation | Endometrial Cancer Cell Line | Gene: RPE (ribulose-5-phosphate-3-epimerase)
Type: protein-coding
Summary: Enables metal ion binding activity; protein homodimerization activity; and ribulose-phosphate 3-epimerase activity. Involved in carbohydrate metabolic process and pentose-phosphate shunt. Located in extracellular exosome. [provid... |
Does Knockout of PPP2R5A in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | PPP2R5A | cell proliferation | Neuroblastoma Cell Line | Gene: PPP2R5A (protein phosphatase 2 regulatory subunit B'alpha)
Type: protein-coding
Summary: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell gr... |
Does Knockout of NHP2 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | NHP2 | response to chemicals | Monocytic Leukemia Cell Line | Gene: NHP2 (NHP2 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA ... |
Does Knockout of SH2D7 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | SH2D7 | cell proliferation | Glioblastoma Cell Line | Gene: SH2D7 (SH2 domain containing 7)
Type: protein-coding
Summary: Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A6NKC9
Entrez ID: 646892 |
Does Knockout of ZFP36 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | ZFP36 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ZFP36 (ZFP36 ring finger protein)
Type: protein-coding
Summary: Enables several functions, including 14-3-3 protein binding activity; heat shock protein binding activity; and mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including cellular response to cytokine stimulu... |
Does Knockout of PSMA1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | PSMA1 | cell proliferation | Medulloblastoma Cell Line | Gene: PSMA1 (proteasome 20S subunit alpha 1)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 ri... |
Does Knockout of CCL28 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | CCL28 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: CCL28 (C-C motif chemokine ligand 28)
Type: protein-coding
Summary: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two a... |
Does Knockout of TRAV3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | TRAV3 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: TRAV3 (T cell receptor alpha variable 3)
Type: other
Summary: T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer cons... |
Does Knockout of TMEM132D in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | TMEM132D | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: TMEM132D (transmembrane protein 132D)
Type: protein-coding
Summary: Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: membrane
Pathways:
UniProt: Q14C87
Entrez ID: 121256 |
Does Knockout of ZNF75D in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | ZNF75D | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ZNF75D (zinc finger protein 75D)
Type: protein-coding
Summary: This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene... |
Does Knockout of GSTM5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | GSTM5 | cell proliferation | Colonic Cancer Cell Line | Gene: GSTM5 (glutathione S-transferase mu 5)
Type: protein-coding
Summary: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identifi... |
Does Knockout of DEK in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | DEK | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: DEK (DEK proto-oncogene)
Type: protein-coding
Summary: This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal a... |
Does Knockout of ZNF468 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | ZNF468 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: ZNF468 (zinc finger protein 468)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of PKNOX2 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | PKNOX2 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: PKNOX2 (PBX/knotted 1 homeobox 2)
Type: protein-coding
Summary: Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid l... |
Does Knockout of SDHD in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | SDHD | cell proliferation | Colonic Cancer Cell Line | Gene: SDHD (succinate dehydrogenase complex subunit D)
Type: protein-coding
Summary: This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix si... |
Does Knockout of CFB in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | CFB | cell proliferation | Astrocytoma Cell Line | Gene: CFB (complement factor B)
Type: protein-coding
Summary: This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement fa... |
Does Knockout of MAU2 in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | MAU2 | response to virus | Hepatoma Cell Line | Gene: MAU2 (MAU2 sister chromatid cohesion factor)
Type: protein-coding
Summary: Enables protein N-terminus binding activity. Involved in cohesin loading and maintenance of mitotic sister chromatid cohesion. Located in chromatin and nuclear body. Part of Scc2-Scc4 cohesin loading complex. [provided by A... |
Does Knockout of RIPK3 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | RIPK3 | response to chemicals | Colorectal Cancer Cell Line | Gene: RIPK3 (receptor interacting serine/threonine kinase 3)
Type: protein-coding
Summary: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein... |
Does Knockout of LARGE2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | LARGE2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: LARGE2 (LARGE xylosyl- and glucuronyltransferase 2)
Type: protein-coding
Summary: Predicted to enable dystroglycan binding activity; glucuronosyltransferase activity; and xylosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in intracellular membrane-boun... |
Does Knockout of CDC27 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | CDC27 | cell proliferation | Cancer Cell Line | Gene: CDC27 (cell division cycle 27)
Type: protein-coding
Summary: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is... |
Does Knockout of NCBP1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | NCBP1 | cell proliferation | Glioblastoma Cell Line | Gene: NCBP1 (nuclear cap binding protein subunit 1)
Type: protein-coding
Summary: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap... |
Does Knockout of DBF4 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | DBF4 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: DBF4 (DBF4-CDC7 kinase regulatory subunit)
Type: protein-coding
Summary: Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Located in nuclear b... |
Does Knockout of NECTIN4 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | NECTIN4 | cell proliferation | Colonic Cancer Cell Line | Gene: NECTIN4 (nectin cell adhesion molecule 4)
Type: protein-coding
Summary: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heter... |
Does Knockout of PRR3 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | PRR3 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: PRR3 (proline rich 3)
Type: protein-coding
Summary: Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: P79522
Entrez ID: 80742 |
Does Knockout of SUPT16H in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | SUPT16H | cell proliferation | Mammary Gland Tumor Cell Line | Gene: SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit)
Type: protein-coding
Summary: Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged int... |
Does Knockout of CTRL in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | CTRL | cell proliferation | Gastric Cancer Cell Line | Gene: CTRL (chymotrypsin like)
Type: protein-coding
Summary: This gene encodes a serine-type endopeptidase with chymotrypsin- and elastase-2-like activities. The gene encoding this zymogen is expressed specifically in the pancreas and likely functions as a digestive enzyme. [provided by RefSeq, Sep 2016... |
Does Knockout of GTF2H2C_2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | GTF2H2C_2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: GTF2H2C_2 (GTF2H2 family member C, copy 2)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in nucleotide-excision repair and regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, ... |
Does Knockout of STX4 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | STX4 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: STX4 (syntaxin 4)
Type: protein-coding
Summary: Enables sphingomyelin phosphodiesterase activator activity. Involved in several processes, including cornified envelope assembly; positive regulation of immune effector process; and positive regulation of protein localization. Located in several cell... |
Does Knockout of ZFP69B in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | ZFP69B | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ZFP69B (ZFP69 zinc finger protein B)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Golgi organization. Located in n... |
Does Knockout of GNL3L in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | GNL3L | cell proliferation | Gastric Cancer Cell Line | Gene: GNL3L (G protein nucleolar 3 like)
Type: protein-coding
Summary: The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided ... |
Does Knockout of TGFBRAP1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | TGFBRAP1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: TGFBRAP1 (transforming growth factor beta receptor associated protein 1)
Type: protein-coding
Summary: This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstre... |
Does Knockout of TMEM61 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | TMEM61 | cell proliferation | Colonic Cancer Cell Line | Gene: TMEM61 (transmembrane protein 61)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8N0U2
Entrez ID: 199964 |
Does Knockout of UBR4 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | UBR4 | cell proliferation | Colonic Cancer Cell Line | Gene: UBR4 (ubiquitin protein ligase E3 component n-recognin 4)
Type: protein-coding
Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protei... |
Does Knockout of RASEF in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | RASEF | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: RASEF (RAS and EF-hand domain containing)
Type: protein-coding
Summary: This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential ro... |
Does Knockout of KATNAL2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | KATNAL2 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: KATNAL2 (katanin catalytic subunit A1 like 2)
Type: protein-coding
Summary: Predicted to enable microtubule-severing ATPase activity. Predicted to be involved in cytoplasmic microtubule organization. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Ap... |
Does Knockout of U2SURP in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | U2SURP | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: U2SURP (U2 snRNP associated SURP domain containing)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in RNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, nucleic acid binding, pr... |
Does Knockout of SSRP1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | SSRP1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SSRP1 (structure specific recognition protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome dis... |
Does Knockout of TRPV3 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | TRPV3 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: TRPV3 (transient receptor potential cation channel subfamily V member 3)
Type: protein-coding
Summary: This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of t... |
Does Knockout of ZNF644 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | ZNF644 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: ZNF644 (zinc finger protein 644)
Type: protein-coding
Summary: The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have ... |
Does Knockout of UBE2I in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | UBE2I | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: UBE2I (ubiquitin conjugating enzyme E2 I)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enz... |
Does Knockout of ETV7 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | ETV7 | cell proliferation | Ovarian Cancer Cell Line | Gene: ETV7 (ETS variant transcription factor 7)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes ... |
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