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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of ACTR10 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
ACTR10
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: ACTR10 (actin related protein 10)
Type: protein-coding
Summary: Predicted to be involved in retrograde axonal transport of mitochondrion. Predicted to be located in cytosol; extracellular region; and secretory granule. Predicted to be part of dynactin complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: microtubule-based movement, retrograde axonal transport of mitochondrion; CC: axon cytoplasm, azurophil granule lumen, cytoplasm, cytoskeleton, cytosol, dynactin complex, extracellular region, ficolin-1-rich granule lumen
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Salmonella infection - Homo sapiens (human), TCR, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9NZ32
Entrez ID: 55860
|
Does Knockout of MAN2A1 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
MAN2A1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: MAN2A1 (mannosidase alpha class 2A member 1)
Type: protein-coding
Summary: This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: N-glycan processing, carbohydrate metabolic process, in utero embryonic development, liver development, lung alveolus development, mannose metabolic process, mitochondrion organization, positive regulation of neurogenesis, protein glycosylation, respiratory gaseous exchange by respiratory system, retina morphogenesis in camera-type eye, vacuole organization, viral protein processing; MF: alpha-mannosidase activity, carbohydrate binding, catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing N-glycosyl compounds, mannosidase activity, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity, metal ion binding; CC: Golgi apparatus, Golgi medial cisterna, Golgi membrane, cis-Golgi network, extracellular exosome, extracellular space, membrane
Pathways: Asparagine N-linked glycosylation, Disease, Infectious disease, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Membrane Trafficking, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), N-glycan antennae elongation in the medial/trans-Golgi, Post-translational protein modification, Reactions specific to the complex N-glycan synthesis pathway, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Transport to the Golgi and subsequent modification, Various types of N-glycan biosynthesis - Homo sapiens (human), Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q16706
Entrez ID: 4124
|
Does Knockout of CDC45 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
CDC45
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CDC45 (cell division cycle 45)
Type: protein-coding
Summary: The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: DNA replication, DNA replication checkpoint signaling, DNA replication initiation, double-strand break repair via break-induced replication, mitotic DNA replication preinitiation complex assembly; MF: DNA replication origin binding, chromatin binding, protein binding, single-stranded DNA binding; CC: CMG complex, DNA replication preinitiation complex, centrosome, chromosome, ciliary basal body, nucleoplasm, nucleus
Pathways: 22q11.2 copy number variation syndrome, Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), DNA Replication, DNA Replication Pre-Initiation, DNA strand elongation, G1 to S cell cycle control, G1/S Transition, G1/S-Specific Transcription, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: O75419
Entrez ID: 8318
|
Does Knockout of KHDC1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
KHDC1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: KHDC1 (KH domain containing 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and poly(U) RNA binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding; CC: cytoplasm, membrane
Pathways:
UniProt: Q4VXA5
Entrez ID: 80759
|
Does Knockout of LTB4R2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
LTB4R2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: LTB4R2 (leukotriene B4 receptor 2)
Type: protein-coding
Summary: Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within keratinocyte migration and signal transduction. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, chemotaxis, keratinocyte migration, leukotriene signaling pathway, negative regulation of adenylate cyclase activity, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, leukotriene B4 receptor activity, leukotriene receptor activity; CC: membrane, nucleoplasm, plasma membrane
Pathways: Calcium signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, Eicosanoid metabolism via lipooxygenases (LOX), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Other, Leukotriene receptors, Neuroactive ligand-receptor interaction - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q9NPC1
Entrez ID: 56413
|
Does Knockout of POT1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
POT1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: POT1 (protection of telomeres 1)
Type: protein-coding
Summary: This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: establishment of protein localization to telomere, negative regulation of telomere maintenance via telomerase, positive regulation of DNA strand elongation, positive regulation of telomere maintenance, positive regulation of telomere maintenance via telomerase, positive regulation of telomeric D-loop disassembly, regulation of double-strand break repair via nonhomologous end joining, regulation of telomere maintenance via telomerase, telomere assembly, telomere capping, telomere maintenance, telomere maintenance via telomerase, telomeric D-loop disassembly; MF: 8-hydroxy-2'-deoxyguanosine DNA binding, DEAD/H-box RNA helicase binding, DNA binding, G-rich single-stranded DNA binding, G-rich strand telomeric DNA binding, protein binding, single-stranded telomeric DNA binding, telomerase inhibitor activity, telomeric D-loop binding, telomeric DNA binding, telomeric G-quadruplex DNA binding; CC: chromosome, chromosome, telomeric region, nuclear telomere cap complex, nucleoplasm, nucleus, shelterin complex
Pathways: Base Excision Repair, Base-Excision Repair, AP Site Formation, Cell Cycle, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromosome Maintenance, Cleavage of the damaged purine, Cleavage of the damaged pyrimidine , DNA Damage/Telomere Stress Induced Senescence, DNA Repair, Depurination, Depyrimidination, Extension of Telomeres, Inhibition of DNA recombination at telomere, Meiosis, Meiotic synapsis, Packaging Of Telomere Ends, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Recognition and association of DNA glycosylase with site containing an affected purine, Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Regulation of Telomerase, Removal of the Flap Intermediate from the C-strand, Reproduction, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q9NUX5
Entrez ID: 25913
|
Does Knockout of TCAF1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
TCAF1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: TCAF1 (TRPM8 channel associated factor 1)
Type: protein-coding
Summary: Enables transmembrane transporter binding activity. Involved in negative regulation of cell migration; positive regulation of anion channel activity; and positive regulation of protein targeting to membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of cell migration, positive regulation of anion channel activity, positive regulation of protein targeting to membrane; MF: protein binding, transmembrane transporter binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9Y4C2
Entrez ID: 9747
|
Does Activation of WFDC12 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
WFDC12
|
protein/peptide accumulation
|
T cell
|
Gene: WFDC12 (WAP four-disulfide core domain 12)
Type: protein-coding
Summary: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: antibacterial humoral response, defense response to bacterium, innate immune response; MF: peptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8WWY7
Entrez ID: 128488
|
Does Knockout of SACM1L in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
SACM1L
|
cell proliferation
|
Cancer Cell Line
|
Gene: SACM1L (SAC1 like phosphatidylinositide phosphatase)
Type: protein-coding
Summary: This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame, downstream translation termination codon via a stop codon readthrough mechanism.[provided by RefSeq, Dec 2017].
Gene Ontology: BP: exocytic insertion of neurotransmitter receptor to postsynaptic membrane, lipid metabolic process, phosphatidylinositol biosynthetic process, phosphatidylinositol dephosphorylation, vesicle-mediated transport in synapse; MF: hydrolase activity, phosphatase activity, phosphatidylinositol phosphate 4-phosphatase activity, phosphatidylinositol-3-phosphate phosphatase activity, phosphatidylinositol-4-phosphate phosphatase activity, protein binding; CC: AMPA glutamate receptor complex, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, glutamatergic synapse, membrane
Pathways: 3-phosphoinositide biosynthesis, 3-phosphoinositide degradation, Inositol phosphate metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, PI Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipid metabolism, Synthesis of PIPs at the ER membrane, Synthesis of PIPs at the Golgi membrane, superpathway of inositol phosphate compounds
UniProt: Q9NTJ5
Entrez ID: 22908
|
Does Knockout of INTS5 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
INTS5
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: INTS5 (integrator complex subunit 5)
Type: protein-coding
Summary: The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, regulation of transcription elongation by RNA polymerase II, snRNA 3'-end processing, snRNA processing; CC: INTAC complex, cytoplasm, cytosol, integrator complex, membrane, nuclear membrane, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q6P9B9
Entrez ID: 80789
|
Does Knockout of UTP15 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
UTP15
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: UTP15 (UTP15 small subunit processome component)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in endoplasmic reticulum and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding; CC: cytoplasm, endoplasmic reticulum, fibrillar center, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8TED0
Entrez ID: 84135
|
Does Knockout of CCNF in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
CCNF
|
cell proliferation
|
Cancer Cell Line
|
Gene: CCNF (cyclin F)
Type: protein-coding
Summary: This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cell division, negative regulation of centrosome duplication, placenta development, protein ubiquitination, re-entry into mitotic cell cycle, regulation of cell cycle; MF: anaphase-promoting complex binding, cyclin-dependent protein serine/threonine kinase regulator activity, protein binding; CC: SCF ubiquitin ligase complex, centriole, centrosome, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytoskeleton, cytosol, microtubule organizing center, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: P41002
Entrez ID: 899
|
Does Knockout of WBP11 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
WBP11
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: WBP11 (WW domain binding protein 11)
Type: protein-coding
Summary: This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, rRNA processing; MF: RNA binding, WW domain binding, protein binding, single-stranded DNA binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9Y2W2
Entrez ID: 51729
|
Does Knockout of ADM2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
ADM2
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ADM2 (adrenomedullin 2)
Type: protein-coding
Summary: This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: adenylate cyclase-activating G protein-coupled receptor signaling pathway, adrenomedullin receptor signaling pathway, angiogenesis, feeding behavior, negative regulation of blood pressure, positive regulation of angiogenesis, positive regulation of gene expression, positive regulation of heart rate, protein phosphorylation, regulation of systemic arterial blood pressure; MF: hormone activity, protein-containing complex binding; CC: extracellular region, extracellular space
Pathways: Calcitonin-like ligand receptors, Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Signal Transduction, Signaling by GPCR
UniProt: Q7Z4H4
Entrez ID: 79924
|
Does Knockout of ZNF792 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
ZNF792
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ZNF792 (zinc finger protein 792)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q3KQV3
Entrez ID: 126375
|
Does Knockout of KIF15 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
KIF15
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: KIF15 (kinesin family member 15)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity and microtubule motor activity. Predicted to be involved in microtubule-based movement. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: centrosome separation, microtubule-based movement, mitotic cell cycle, mitotic spindle assembly; MF: ATP binding, ATP hydrolysis activity, cytoskeletal motor activity, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, kinesin complex, membrane, microtubule, plus-end kinesin complex, spindle, spindle pole
Pathways: Adaptive Immune System, COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Gastric Cancer Network 1, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Vesicle-mediated transport, role of ran in mitotic spindle regulation
UniProt: Q9NS87
Entrez ID: 56992
|
Does Activation of ANKRD13A in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
ANKRD13A
|
protein/peptide accumulation
|
T cell
|
Gene: ANKRD13A (ankyrin repeat domain 13A)
Type: protein-coding
Summary: Enables ubiquitin-dependent protein binding activity. Involved in negative regulation of protein localization to endosome and negative regulation of receptor internalization. Located in late endosome; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of protein localization to endosome, negative regulation of receptor internalization; MF: ubiquitin-modified protein reader activity; CC: cytoplasm, endosome, late endosome, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q8IZ07
Entrez ID: 88455
|
Does Knockout of UQCRC2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
UQCRC2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: UQCRC2 (ubiquinol-cytochrome c reductase core protein 2)
Type: protein-coding
Summary: The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: aerobic respiration, cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, oxidative phosphorylation, proteolysis; MF: metal ion binding, metalloendopeptidase activity, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Complex III assembly, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Metabolism of proteins, Mitochondrial complex III assembly, Mitochondrial protein degradation, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: P22695
Entrez ID: 7385
|
Does Knockout of EBNA1BP2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
EBNA1BP2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: EBNA1BP2 (EBNA1 binding protein 2)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding; CC: chromosome, nuclear periphery, nucleolus, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q99848
Entrez ID: 10969
|
Does Knockout of ZCWPW2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
ZCWPW2
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ZCWPW2 (zinc finger CW-type and PWWP domain containing 2)
Type: protein-coding
Summary: Enables methylated histone binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: histone H3K4me3 reader activity, metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: Q504Y3
Entrez ID: 152098
|
Does Knockout of ASPHD2 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
ASPHD2
|
response to virus
|
Hepatoma Cell Line
|
Gene: ASPHD2 (aspartate beta-hydroxylase domain containing 2)
Type: protein-coding
Summary: Predicted to enable dioxygenase activity and metal ion binding activity. Predicted to be involved in peptidyl-amino acid modification. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: dioxygenase activity, metal ion binding, oxidoreductase activity, protein binding; CC: membrane
Pathways:
UniProt: Q6ICH7
Entrez ID: 57168
|
Does Activation of NUP188 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
NUP188
|
protein/peptide accumulation
|
T cell
|
Gene: NUP188 (nucleoporin 188)
Type: protein-coding
Summary: The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: RNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein import into nucleus, protein transport; MF: structural constituent of nuclear pore; CC: cytosol, membrane, nuclear envelope, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q5SRE5
Entrez ID: 23511
|
Does Knockout of TMSB10 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
TMSB10
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TMSB10 (thymosin beta 10)
Type: protein-coding
Summary: Predicted to enable actin monomer binding activity. Predicted to be involved in regulation of cell migration and sequestering of actin monomers. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin filament organization, regulation of cell migration; MF: actin binding, actin monomer binding, protein binding, protein sequestering activity; CC: cytoplasm, cytoskeleton
Pathways: VEGFA-VEGFR2 Signaling Pathway
UniProt: P63313
Entrez ID: 9168
|
Does Knockout of ARGLU1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
ARGLU1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ARGLU1 (arginine and glutamate rich 1)
Type: protein-coding
Summary: Enables cadherin binding activity. Located in cytosol; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, positive regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, cadherin binding, pre-mRNA binding, protein binding, transcription coactivator activity; CC: chromosome, cytosol, mitochondrion, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q9NWB6
Entrez ID: 55082
|
Does Knockout of FBXO30 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
FBXO30
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: FBXO30 (F-box protein 30)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin organization, chromosome condensation, chromosome segregation, gene expression, protein ubiquitination; MF: metal ion binding, protein binding, ubiquitin protein ligase activity, zinc ion binding
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q8TB52
Entrez ID: 84085
|
Does Knockout of ADCK2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
ADCK2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ADCK2 (aarF domain containing kinase 2)
Type: protein-coding
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein serine/threonine kinase activity, transferase activity; CC: membrane, mitochondrion
Pathways:
UniProt: Q7Z695
Entrez ID: 90956
|
Does Inhibition of MRPL19 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
MRPL19
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MRPL19 (mitochondrial ribosomal protein L19)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nucleus, ribonucleoprotein complex, ribosome
Pathways: Cytoplasmic Ribosomal Proteins, Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: P49406
Entrez ID: 9801
|
Does Knockout of GEMIN4 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
GEMIN4
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: GEMIN4 (gem nuclear organelle associated protein 4)
Type: protein-coding
Summary: The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA processing, rRNA processing, spliceosomal snRNP assembly; MF: protein binding, ribonucleoprotein complex binding; CC: Cajal body, Gemini of Cajal bodies, SMN complex, SMN-Sm protein complex, cytoplasm, cytosol, extracellular exosome, membrane, nuclear body, nucleolus, nucleoplasm, nucleus, small nuclear ribonucleoprotein complex
Pathways: Disease, Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, RNA transport - Homo sapiens (human), SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, Viral Infection Pathways, snRNP Assembly
UniProt: P57678
Entrez ID: 50628
|
Does Knockout of ZNF300 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
ZNF300
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: ZNF300 (zinc finger protein 300)
Type: protein-coding
Summary: The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: nuclear body, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q96RE9
Entrez ID: 91975
|
Does Knockout of MLST8 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
MLST8
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: MLST8 (MTOR associated protein MLST8)
Type: protein-coding
Summary: Enables protein serine/threonine kinase activator activity. Involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, TOR signaling, TORC1 signaling, TORC2 signaling, cellular response to hypoxia, cellular response to nutrient levels, cellular response to osmotic stress, cytoskeleton organization, negative regulation of apoptotic process, negative regulation of autophagy, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of TOR signaling, positive regulation of actin filament polymerization, positive regulation of cell growth, positive regulation of glycolytic process, positive regulation of lipid biosynthetic process, positive regulation of pentose-phosphate shunt, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of actin cytoskeleton organization; MF: protein binding, protein serine/threonine kinase activator activity, protein-macromolecule adaptor activity; CC: TORC1 complex, TORC2 complex, cytoplasm, cytosol, lysosomal membrane, lysosome, membrane, nucleoplasm, serine/threonine protein kinase complex
Pathways: Adaptive Immune System, Amino acids regulate mTORC1, Angiopoietin Like Protein 8 Regulatory Pathway, Autophagy, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), CD28 dependent PI3K/Akt signaling, CXCR3-mediated signaling events, CXCR4-mediated signaling events, Cellular response to heat stress, Cellular response to starvation, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Cellular responses to stress, Class I PI3K signaling events mediated by Akt, Co-stimulation by CD28, Constitutive Signaling by AKT1 E17K in Cancer, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Energy dependent regulation of mTOR by LKB1-AMPK, ErbB1 downstream signaling, Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Fragile X Syndrome, Gene expression (Transcription), Generic Transcription Pathway, HSF1-dependent transactivation, Head and Neck Squamous Cell Carcinoma, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Immune System, Interferon type I signaling pathways, Intracellular signaling by second messengers, LKB1 signaling events, MTOR signalling, Macroautophagy, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, PTEN Regulation, Pathways in clear cell renal cell carcinoma, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of toll-like receptor signaling pathway, Regulatory circuits of the STAT3 signaling pathway, Response of endothelial cells to shear stress, Senescence and Autophagy in Cancer, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), TP53 Regulates Metabolic Genes, Target Of Rapamycin (TOR) Signaling, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, Transcriptional Regulation by TP53, VEGFA-VEGFR2 Pathway, VEGFA-VEGFR2 Signaling Pathway, VEGFR2 mediated vascular permeability, mTOR signaling pathway, mTOR signaling pathway - Homo sapiens (human), mTORC1-mediated signalling
UniProt: Q9BVC4
Entrez ID: 64223
|
Does Knockout of FAM32A in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
FAM32A
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: FAM32A (family with sequence similarity 32 member A)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in apoptotic process. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protein binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9Y421
Entrez ID: 26017
|
Does Knockout of AGBL4 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
AGBL4
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: AGBL4 (AGBL carboxypeptidase 4)
Type: protein-coding
Summary: Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Predicted to be involved in C-terminal protein deglutamylation; defense response to virus; and protein side chain deglutamylation. Predicted to act upstream of or within several processes, including axonal transport of mitochondrion; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of blastocyst development. Located in Golgi apparatus; centriole; and ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: C-terminal protein deglutamylation, anterograde axonal transport of mitochondrion, axonal transport, central nervous system neuron development, defense response to virus, negative regulation of cell population proliferation, positive regulation of ubiquitin-dependent protein catabolic process, protein deglutamylation, protein side chain deglutamylation, proteolysis, regulation of blastocyst development, retrograde axonal transport of mitochondrion; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, tubulin binding, zinc ion binding; CC: Golgi apparatus, axon, axon cytoplasm, cell projection, centriole, ciliary basal body, cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: Q5VU57
Entrez ID: 84871
|
Does Knockout of FANCD2OS in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
FANCD2OS
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: FANCD2OS (FANCD2 opposite strand)
Type: protein-coding
Summary: This gene encodes a conserved protein of unknown function. [provided by RefSeq, Jan 2013].
Gene Ontology:
Pathways:
UniProt: Q96PS1
Entrez ID: 115795
|
Does Knockout of TOMM20 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
TOMM20
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: TOMM20 (translocase of outer mitochondrial membrane 20)
Type: protein-coding
Summary: Enables protein-transporting ATPase activity and unfolded protein binding activity. Involved in protein targeting to mitochondrion. Located in mitochondria-associated endoplasmic reticulum membrane and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intracellular protein transport, protein import into mitochondrial matrix, protein insertion into mitochondrial outer membrane, protein targeting, protein targeting to mitochondrion, protein transport, tRNA import into mitochondrion; MF: mitochondrion targeting sequence binding, protein binding, protein transmembrane transporter activity, protein-transporting ATPase activity, unfolded protein binding; CC: TOM complex, cell periphery, membrane, migrasome, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial envelope, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion, sperm midpiece
Pathways: Autophagy, Deubiquitination, Macroautophagy, Metabolism of proteins, Mitochondrial protein import, Mitophagy, PINK1-PRKN Mediated Mitophagy, Post-translational protein modification, Protein localization, Selective autophagy, Ub-specific processing proteases
UniProt: Q15388
Entrez ID: 9804
|
Does Knockout of PCDH20 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
PCDH20
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: PCDH20 (protocadherin 20)
Type: protein-coding
Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: RNA binding, calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q8N6Y1
Entrez ID: 64881
|
Does Knockout of UQCRH in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
UQCRH
|
cell proliferation
|
Bladder Carcinoma
|
Gene: UQCRH (ubiquinol-cytochrome c reductase hinge protein)
Type: protein-coding
Summary: Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: aerobic respiration, cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, oxidative phosphorylation, proton transmembrane transport; MF: protein binding, quinol-cytochrome-c reductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Complex III assembly, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Mitochondrial complex III assembly, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: P07919
Entrez ID: 7388
|
Does Knockout of GPR61 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
GPR61
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: GPR61 (G protein-coupled receptor 61)
Type: protein-coding
Summary: This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, arrestin family protein binding, protein binding; CC: endosome, endosome membrane, membrane, plasma membrane, receptor complex
Pathways: GPCRs, Other
UniProt: Q9BZJ8
Entrez ID: 83873
|
Does Knockout of CSE1L in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
CSE1L
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: CSE1L (chromosome segregation 1 like)
Type: protein-coding
Summary: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: intracellular protein transport, protein export from nucleus, protein import into nucleus, protein transport; MF: nuclear export signal receptor activity, protein binding, small GTPase binding; CC: cytoplasm, cytosol, extracellular exosome, membrane, nuclear envelope, nucleoplasm, nucleus
Pathways: Direct p53 effectors, Salmonella infection - Homo sapiens (human), p53 pathway
UniProt: P55060
Entrez ID: 1434
|
Does Knockout of DIS3 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
DIS3
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: DIS3 (DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease)
Type: protein-coding
Summary: Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CUT catabolic process, RNA catabolic process, RNA processing, nuclear mRNA surveillance of mRNA 3'-end processing, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, rRNA catabolic process, rRNA processing; MF: 3'-5'-RNA exonuclease activity, RNA binding, RNA nuclease activity, endonuclease activity, exonuclease activity, guanyl-nucleotide exchange factor activity, hydrolase activity, nuclease activity, protein binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, exosome (RNase complex), membrane, nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Cellular responses to stimuli, Cellular responses to stress, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, PERK regulates gene expression, RNA degradation - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, Unfolded Protein Response (UPR), mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y2L1
Entrez ID: 22894
|
Does Knockout of GPSM2 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
GPSM2
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: GPSM2 (G protein signaling modulator 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell division, establishment of mitotic spindle orientation, maintenance of centrosome location, mitotic spindle organization, neurotransmitter receptor localization to postsynaptic specialization membrane, positive regulation of protein localization to cell cortex, positive regulation of spindle assembly, regulation of mitotic spindle organization, response to light intensity; MF: G-protein alpha-subunit binding, GDP-dissociation inhibitor activity, GTPase regulator activity, dynein complex binding, identical protein binding, nucleotide binding, protein binding, protein domain specific binding; CC: cell cortex, cell cortex region, centrosome, cytoplasm, cytoskeleton, cytosol, lateral cell cortex, lateral plasma membrane, membrane, mitotic spindle pole, plasma membrane, postsynaptic density, protein-containing complex, spindle pole
Pathways: G alpha (i) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: P81274
Entrez ID: 29899
|
Does Knockout of MAP3K3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
MAP3K3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MAP3K3 (mitogen-activated protein kinase kinase kinase 3)
Type: protein-coding
Summary: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, blood vessel development, intracellular signal transduction, positive regulation of canonical NF-kappaB signal transduction, positive regulation of p38MAPK cascade, protein autophosphorylation; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, Cytokine Signaling in Immune system, EGF-EGFR signaling pathway, EGFR1, Ebstein-Barr virus LMP1 signaling, GnRH signaling pathway - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), IL-1 signaling pathway, IL1-mediated signaling events, Immune System, Insulin Signaling, Interleukin-1 family signaling, Interleukin-1 signaling, MAPK Cascade, MAPK signaling pathway - Homo sapiens (human), Neurotrophin signaling pathway - Homo sapiens (human), PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), Regulation of p38-alpha and p38-beta, Signaling by Interleukins, Structural Pathway of Interleukin 1 (IL-1), TNF receptor signaling pathway , TNF-alpha signaling pathway, TNFalpha, mapkinase signaling pathway, p38 MAPK signaling pathway
UniProt: Q99759
Entrez ID: 4215
|
Does Knockout of BIVM in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
BIVM
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: BIVM (basic, immunoglobulin-like variable motif containing)
Type: protein-coding
Summary: Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA endonuclease activity, protein binding, single-stranded DNA binding; CC: cytoplasm, extracellular space, nucleus
Pathways:
UniProt: Q86UB2
Entrez ID: 54841
|
Does Knockout of LAMP5 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
LAMP5
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: LAMP5 (lysosomal associated membrane protein family member 5)
Type: protein-coding
Summary: Predicted to be involved in establishment of protein localization to organelle. Located in endoplasmic reticulum-Golgi intermediate compartment membrane; endosome membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: establishment of protein localization to organelle, presynaptic modulation of chemical synaptic transmission; CC: GABA-ergic synapse, cell projection, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendrite, dendrite membrane, early endosome membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, endosome, endosome membrane, growth cone membrane, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, plasma membrane, recycling endosome, recycling endosome membrane, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways:
UniProt: Q9UJQ1
Entrez ID: 24141
|
Does Knockout of CTR9 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
CTR9
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: CTR9 (CTR9 component of Paf1/RNA polymerase II complex)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the PAF1 complex, which associates with RNA polymerase II and functions in transcriptional regulation and elongation. This complex also plays a role in the modification of histones. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: Wnt signaling pathway, blastocyst growth, blastocyst hatching, cell surface receptor signaling pathway via JAK-STAT, cellular response to lipopolysaccharide, chromatin organization, endodermal cell fate commitment, inner cell mass cell differentiation, interleukin-6-mediated signaling pathway, negative regulation of gene expression, epigenetic, negative regulation of myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II, trophectodermal cell differentiation; MF: RNA polymerase II complex binding, SH2 domain binding, protein binding; CC: Cdc73/Paf1 complex, euchromatin, nuclear speck, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Endoderm differentiation, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q6PD62
Entrez ID: 9646
|
Does Knockout of NUDT4 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
NUDT4
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: NUDT4 (nudix hydrolase 4)
Type: protein-coding
Summary: The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adenosine 5'-(hexahydrogen pentaphosphate) catabolic process, calcium-mediated signaling, diadenosine hexaphosphate catabolic process, diadenosine pentaphosphate catabolic process, diphosphoinositol polyphosphate metabolic process, intracellular signal transduction; MF: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity, RNA binding, bis(5'-adenosyl)-hexaphosphatase activity, bis(5'-adenosyl)-pentaphosphatase activity, diphosphoinositol-polyphosphate diphosphatase activity, endopolyphosphatase activity, hydrolase activity, inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity, inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity, inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity, metal ion binding, protein binding, pyrophosphatase activity, snoRNA binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q9NZJ9, A0A024RBG1
Entrez ID: 11163
|
Does Knockout of PIK3C2A in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
PIK3C2A
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell migration, clathrin coat assembly, endocytosis, epidermal growth factor receptor signaling pathway, exocytosis, insulin receptor signaling pathway, lipid metabolic process, membrane organization, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol biosynthetic process, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, platelet-derived growth factor receptor signaling pathway, positive regulation of autophagy, positive regulation of cell migration involved in sprouting angiogenesis, vascular associated smooth muscle contraction; MF: 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, clathrin binding, kinase activity, nucleotide binding, phosphatidylinositol binding, transferase activity; CC: Golgi apparatus, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, membrane, nucleoplasm, nucleus, plasma membrane, trans-Golgi network, vesicle
Pathways: 3-phosphoinositide biosynthesis, Angiopoietin Like Protein 8 Regulatory Pathway, Clathrin-mediated endocytosis, DNA damage response (only ATM dependent), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glioblastoma signaling pathways, Golgi Associated Vesicle Biogenesis, Inositol phosphate metabolism - Homo sapiens (human), Insulin Signaling, Integrins in angiogenesis, Joubert syndrome, Membrane Trafficking, Metabolism, Metabolism of lipids, Microglia Pathogen Phagocytosis Pathway, Osteoblast differentiation, PI Metabolism, Phosphatidylinositol Phosphate Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipid metabolism, Regulation of Actin Cytoskeleton, Salmonella infection - Homo sapiens (human), Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, Synthesis of PIPs at the plasma membrane, Vesicle-mediated transport, superpathway of inositol phosphate compounds, trans-Golgi Network Vesicle Budding
UniProt: O00443
Entrez ID: 5286
|
Does Knockout of CCNA2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
CCNA2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CCNA2 (cyclin A2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: DNA-templated transcription, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, Ras protein signal transduction, animal organ regeneration, cell cycle G1/S phase transition, cell division, cellular response to cocaine, cellular response to estradiol stimulus, cellular response to hypoxia, cellular response to insulin-like growth factor stimulus, cellular response to leptin stimulus, cellular response to luteinizing hormone stimulus, cellular response to nitric oxide, cellular response to platelet-derived growth factor stimulus, cochlea development, mitotic cell cycle phase transition, positive regulation of DNA biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of fibroblast proliferation, post-translational protein modification, regulation of DNA replication, response to estradiol, response to glucagon; MF: cyclin-dependent protein serine/threonine kinase regulator activity, protein binding, protein domain specific binding, protein kinase binding; CC: cyclin A2-CDK1 complex, cyclin A2-CDK2 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, female pronucleus, male pronucleus, microtubule organizing center, nucleoplasm, nucleus
Pathways: AMP-activated protein kinase (AMPK) signaling, AMPK signaling pathway - Homo sapiens (human), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of mitotic proteins, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, ATF-2 transcription factor network, ATR signaling pathway, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Acute myeloid leukemia - Homo sapiens (human), CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Homo sapiens (human), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Chromosome Maintenance, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , DNA Damage/Telomere Stress Induced Senescence, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, Deubiquitination, E2F transcription factor network, Epstein-Barr virus infection - Homo sapiens (human), Extension of Telomeres, FOXM1 transcription factor network, G0 and Early G1, G1/S DNA Damage Checkpoints, G1/S Transition, G2 Phase, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M DNA replication checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatitis B - Homo sapiens (human), Homology Directed Repair, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IL-18 signaling pathway, IL2 signaling events mediated by STAT5, Metabolism of proteins, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Orc1 removal from chromatin, Pathways in cancer - Homo sapiens (human), Post-translational protein modification, Processing of DNA double-strand break ends, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of mitotic cell cycle, Regulation of retinoblastoma protein, Retinoblastoma gene in cancer, S Phase, SCF(Skp2)-mediated degradation of p27/p21, Senescence-Associated Secretory Phenotype (SASP), Signaling events mediated by PRL, Switching of origins to a post-replicative state, Synthesis of DNA, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, Telomere Extension By Telomerase, Telomere Maintenance, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1, Transcriptional Regulation by TP53, Transcriptional misregulation in cancer - Homo sapiens (human), Ub-specific processing proteases, Validated transcriptional targets of AP1 family members Fra1 and Fra2, Viral carcinogenesis - Homo sapiens (human), p53 pathway, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p73 transcription factor network
UniProt: P20248
Entrez ID: 890
|
Does Knockout of LRRN3 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
LRRN3
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: LRRN3 (leucine rich repeat neuronal 3)
Type: protein-coding
Summary: Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, signaling receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q9H3W5
Entrez ID: 54674
|
Does Activation of FBLN5 in Mammary Epithelial Cell Line causally result in cell proliferation?
| 0
| 2,280
|
Activation
|
FBLN5
|
cell proliferation
|
Mammary Epithelial Cell Line
|
Gene: FBLN5 (fibulin 5)
Type: protein-coding
Summary: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, cell-matrix adhesion, elastic fiber assembly, extracellular matrix organization, intramembranous bone growth, negative regulation of angiogenesis, negative regulation of transcription by RNA polymerase II, positive regulation of osteoblast proliferation, positive regulation of transcription by RNA polymerase II, protein localization to cell surface, regulation of removal of superoxide radicals, secretion; MF: calcium ion binding, extracellular matrix constituent conferring elasticity, integrin binding, protein binding, protein homodimerization activity; CC: elastic fiber, extracellular exosome, extracellular matrix, extracellular region, extracellular space
Pathways: Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres
UniProt: Q9UBX5
Entrez ID: 10516
|
Does Knockout of CPNE5 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
CPNE5
|
response to virus
|
Hepatoma Cell Line
|
Gene: CPNE5 (copine 5)
Type: protein-coding
Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. More variants may exist, but their full-length natures could not be determined. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cell differentiation, cellular response to calcium ion, positive regulation of dendrite extension; MF: calcium-dependent phospholipid binding, metal ion binding; CC: cell projection, extracellular exosome, neuron projection, neuronal cell body, perikaryon, plasma membrane
Pathways:
UniProt: Q9HCH3
Entrez ID: 57699
|
Does Knockout of INS in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
INS
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: INS (insulin)
Type: protein-coding
Summary: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, TORC1 signaling, acute-phase response, alpha-beta T cell activation, cell-cell signaling, cellular response to oxygen-containing compound, cognition, fatty acid homeostasis, glucose homeostasis, glucose metabolic process, insulin receptor signaling pathway, negative regulation of acute inflammatory response, negative regulation of fatty acid metabolic process, negative regulation of feeding behavior, negative regulation of gene expression, negative regulation of gluconeogenesis, negative regulation of glycogen catabolic process, negative regulation of lipid catabolic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of protein catabolic process, negative regulation of protein secretion, negative regulation of reactive oxygen species biosynthetic process, negative regulation of respiratory burst involved in inflammatory response, negative regulation of ubiquitin-dependent protein catabolic process, neuron projection maintenance, nitric oxide-cGMP-mediated signaling, positive regulation of D-glucose import, positive regulation of MAPK cascade, positive regulation of brown fat cell differentiation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell differentiation, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cytokine production, positive regulation of dendritic spine maintenance, positive regulation of gene expression, positive regulation of glycogen biosynthetic process, positive regulation of glycolytic process, positive regulation of insulin receptor signaling pathway, positive regulation of lipid biosynthetic process, positive regulation of long-term synaptic potentiation, positive regulation of mitotic nuclear division, positive regulation of neuron projection development, positive regulation of nitric oxide mediated signal transduction, positive regulation of nitric-oxide synthase activity, positive regulation of peptide hormone secretion, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to nucleus, positive regulation of protein secretion, positive regulation of respiratory burst, positive regulation of translation, regulation of DNA-templated transcription, regulation of protein localization, regulation of protein localization to plasma membrane, regulation of protein secretion, regulation of synaptic plasticity, vasodilation, wound healing; MF: hormone activity, identical protein binding, insulin receptor binding, insulin-like growth factor receptor binding, protease binding, protein binding, receptor ligand activity; CC: Golgi lumen, Golgi membrane, endoplasmic reticulum lumen, endoplasmic reticulum-Golgi intermediate compartment membrane, endosome lumen, extracellular region, extracellular space, secretory granule lumen, transport vesicle
Pathways: AGE-RAGE pathway, AMPK signaling pathway - Homo sapiens (human), ATF-2 transcription factor network, Adipogenesis, Aldosterone-regulated sodium reabsorption - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Arf6 trafficking events, Autophagy - animal - Homo sapiens (human), Cardiac Progenitor Differentiation, Cori Cycle, Diabetic cardiomyopathy - Homo sapiens (human), Differentiation Pathway, FOXA1 transcription factor network, FOXA2 and FOXA3 transcription factor networks, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Folate Metabolism, FoxO signaling pathway - Homo sapiens (human), Galanin receptor pathway, Glibenclamide Action Pathway, Gliclazide Action Pathway, Glucose Homeostasis, HIF-1 signaling pathway - Homo sapiens (human), Insulin Pathway, Insulin Signalling, Insulin resistance - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Insulin signaling pathway - Homo sapiens (human), Insulin-mediated glucose transport, Leptin Insulin Overlap, Leucine Stimulation on Insulin Signaling, Longevity regulating pathway - Homo sapiens (human), Longevity regulating pathway - multiple species - Homo sapiens (human), MAPK signaling pathway - Homo sapiens (human), Maturity onset diabetes of the young - Homo sapiens (human), Nateglinide Action Pathway, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oocyte meiosis - Homo sapiens (human), Ovarian steroidogenesis - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pancreas Function, Phospholipase D signaling pathway - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), Prolactin signaling pathway - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of lipolysis in adipocytes - Homo sapiens (human), Repaglinide Action Pathway, Selenium Micronutrient Network, Senescence and Autophagy in Cancer, Signaling events mediated by PTP1B, Signaling events mediated by TCPTP, Type I diabetes mellitus - Homo sapiens (human), Type II diabetes mellitus - Homo sapiens (human), Vitamin B12 metabolism, White fat cell differentiation, cGMP-PKG signaling pathway - Homo sapiens (human), growth hormone signaling pathway, insulin signaling pathway, mTOR signaling pathway - Homo sapiens (human)
UniProt: P01308
Entrez ID: 3630
|
Does Knockout of PPM1G in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
PPM1G
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010].
Gene Ontology: BP: peptidyl-threonine dephosphorylation, protein dephosphorylation, regulation of cell cycle, signal transduction; MF: cation binding, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity; CC: cytoplasm, membrane, nucleoplasm, nucleus
Pathways: VEGFA-VEGFR2 Signaling Pathway, mRNA Processing
UniProt: O15355
Entrez ID: 5496
|
Does Knockout of SUPT4H1 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
SUPT4H1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit)
Type: protein-coding
Summary: This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: negative regulation of DNA-templated transcription, elongation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription elongation by RNA polymerase II, transcription elongation by RNA polymerase II, transcription elongation-coupled chromatin remodeling; MF: RNA polymerase II complex binding, metal ion binding, protein binding, protein heterodimerization activity, zinc ion binding; CC: DSIF complex, nucleoplasm, nucleus
Pathways: Abortive elongation of HIV-1 transcript in the absence of Tat, Disease, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV elongation arrest and recovery, Infectious disease, Initiation of transcription and translation elongation at the HIV-1 LTR, Late Phase of HIV Life Cycle, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA polymerase II transcribes snRNA genes, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcriptional Regulation by TP53, Viral Infection Pathways
UniProt: P63272
Entrez ID: 6827
|
Does Knockout of XRN1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
XRN1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: XRN1 (5'-3' exoribonuclease 1)
Type: protein-coding
Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: RNA metabolic process, cellular response to cycloheximide, cellular response to puromycin, histone mRNA catabolic process, negative regulation of telomere maintenance via telomerase, negative regulation of translation, nuclear mRNA surveillance, nuclear-transcribed mRNA catabolic process, rRNA catabolic process, response to testosterone; MF: 5'-3' RNA exonuclease activity, 5'-3' exonuclease activity, DNA binding, G-quadruplex DNA binding, G-quadruplex RNA binding, RNA binding, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, protein binding, telomerase RNA binding; CC: P-body, cytoplasm, cytosol, dendrite, membrane, neuronal cell body, nucleus, plasma membrane
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q8IZH2
Entrez ID: 54464
|
Does Knockout of HIC2 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
HIC2
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: HIC2 (HIC ZBTB transcriptional repressor 2)
Type: protein-coding
Summary: Enables protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q96JB3
Entrez ID: 23119
|
Does Knockout of UBE2G2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
UBE2G2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: UBE2G2 (ubiquitin conjugating enzyme E2 G2)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: ERAD pathway, cellular response to interferon-beta, negative regulation of retrograde protein transport, ER to cytosol, protein K48-linked ubiquitination, protein modification by small protein conjugation, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, identical protein binding, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity; CC: cytosol, endoplasmic reticulum, lipid droplet
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Parkinson,s disease pathway, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Homo sapiens (human), role of parkin in ubiquitin-proteasomal pathway
UniProt: P60604
Entrez ID: 7327
|
Does Knockout of GUK1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
GUK1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: GUK1 (guanylate kinase 1)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: GDP biosynthetic process, GDP-mannose metabolic process, GMP metabolic process, dATP metabolic process, dGDP biosynthetic process, dGMP metabolic process, glycoprotein transport, nucleobase-containing small molecule interconversion, purine nucleotide metabolic process, xenobiotic metabolic process; MF: ATP binding, GMP kinase activity, kinase activity, nucleotide binding, protein binding, transferase activity; CC: cytoplasm, cytosol, mitochondrion, photoreceptor inner segment
Pathways: AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine ADME, Azathioprine Action Pathway, Drug ADME, Gout or Kelley-Seegmiller Syndrome, Interconversion of nucleotide di- and triphosphates, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, guanosine nucleotides <i>de novo</i> biosynthesis, guanosine ribonucleotides <i>de novo</i> biosynthesis, purine deoxyribonucleosides salvage, purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: Q16774
Entrez ID: 2987
|
Does Knockout of MGAT5 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
MGAT5
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: positive regulation of cell migration, positive regulation of receptor signaling pathway via STAT, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, viral protein processing; MF: acetylglucosaminyltransferase activity, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity, glycosyltransferase activity, manganese ion binding, protein phosphatase inhibitor activity, transferase activity; CC: Golgi apparatus, Golgi membrane, extracellular exosome, extracellular region, membrane
Pathways: Asparagine N-linked glycosylation, Disease, Infectious disease, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, N-Glycan antennae elongation, N-Glycan biosynthesis - Homo sapiens (human), N-glycan antennae elongation in the medial/trans-Golgi, Post-translational protein modification, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Transport to the Golgi and subsequent modification, Viral Infection Pathways
UniProt: Q09328
Entrez ID: 4249
|
Does Knockout of NTSR2 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
NTSR2
|
response to virus
|
Huh-7 Cell
|
Gene: NTSR2 (neurotensin receptor 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, neuropeptide signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, regulation of membrane potential, sensory perception, signal transduction; MF: G protein-coupled neurotensin receptor activity, G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide GPCRs, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: O95665
Entrez ID: 23620
|
Does Knockout of RPE in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
RPE
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: RPE (ribulose-5-phosphate-3-epimerase)
Type: protein-coding
Summary: Enables metal ion binding activity; protein homodimerization activity; and ribulose-phosphate 3-epimerase activity. Involved in carbohydrate metabolic process and pentose-phosphate shunt. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: carbohydrate metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch; MF: D-ribulose-phosphate 3-epimerase activity, identical protein binding, isomerase activity, metal ion binding, protein binding, protein homodimerization activity, racemase and epimerase activity, acting on carbohydrates and derivatives; CC: cytosol, extracellular exosome
Pathways: Glucose-6-phosphate dehydrogenase deficiency, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose Phosphate Metabolism, Pentose Phosphate Pathway, Pentose and glucuronate interconversions - Homo sapiens (human), Pentose phosphate pathway, Pentose phosphate pathway - Homo sapiens (human), Ribose-5-phosphate isomerase deficiency, Transaldolase deficiency, pentose phosphate pathway, pentose phosphate pathway (non-oxidative branch)
UniProt: Q96AT9
Entrez ID: 6120
|
Does Knockout of PPP2R5A in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
PPP2R5A
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: PPP2R5A (protein phosphatase 2 regulatory subunit B'alpha)
Type: protein-coding
Summary: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: negative regulation of protein localization to plasma membrane, signal transduction; MF: kinase binding, kinase inhibitor activity, protein binding, protein phosphatase activator activity, protein phosphatase regulator activity; CC: M band, Z disc, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytosol, nucleus, plasma membrane, protein phosphatase type 2A complex
Pathways: AMPK signaling pathway - Homo sapiens (human), APC truncation mutants have impaired AXIN binding, AXIN missense mutants destabilize the destruction complex, Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Antiviral mechanism by IFN-stimulated genes, Beta-catenin phosphorylation cascade, C-MYC pathway, CTNNB1 S33 mutants aren't phosphorylated, CTNNB1 S37 mutants aren't phosphorylated, CTNNB1 S45 mutants aren't phosphorylated, CTNNB1 T41 mutants aren't phosphorylated, Canonical Wnt signaling pathway, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Co-inhibition by CTLA4, Co-stimulation by CD28, Cytokine Signaling in Immune system, Degradation of beta-catenin by the destruction complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dopaminergic synapse - Homo sapiens (human), EML4 and NUDC in mitotic spindle formation, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glycogen Synthesis and Degradation, Hemostasis, Human papillomavirus infection - Homo sapiens (human), Immune System, Interferon Signaling, Intracellular signaling by second messengers, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Negative regulation of MAPK pathway, Negative regulation of the PI3K/AKT network, Oocyte meiosis - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PKR-mediated signaling, Platelet homeostasis, Platelet sensitization by LDL, RAF activation, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of T cell activation by CD28 family, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by AMER1 mutants, Signaling by APC mutants, Signaling by AXIN mutants, Signaling by CTNNB1 phospho-site mutants, Signaling by GSK3beta mutants, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Signaling by WNT in cancer, Sphingolipid signaling pathway - Homo sapiens (human), TCF dependent signaling in response to WNT, Truncations of AMER1 destabilize the destruction complex, Validated transcriptional targets of deltaNp63 isoforms, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q15172
Entrez ID: 5525
|
Does Knockout of NHP2 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
NHP2
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: NHP2 (NHP2 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: rRNA processing, rRNA pseudouridine synthesis, ribosome biogenesis, snRNA pseudouridine synthesis, snoRNA guided rRNA pseudouridine synthesis, telomerase RNA localization to Cajal body, telomere maintenance via telomerase; MF: RNA binding, U3 snoRNA binding, box H/ACA snoRNA binding, mRNA 3'-UTR binding, protein binding, telomerase RNA binding; CC: Cajal body, box H/ACA scaRNP complex, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, chromosome, telomeric region, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Telomere Extension By Telomerase, Telomere Maintenance, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NX24
Entrez ID: 55651
|
Does Knockout of SH2D7 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
SH2D7
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SH2D7 (SH2 domain containing 7)
Type: protein-coding
Summary: Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A6NKC9
Entrez ID: 646892
|
Does Knockout of ZFP36 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
ZFP36
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ZFP36 (ZFP36 ring finger protein)
Type: protein-coding
Summary: Enables several functions, including 14-3-3 protein binding activity; heat shock protein binding activity; and mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to growth factor stimulus; and regulation of gene expression. Acts upstream of or within mRNA catabolic process. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Part of ribonucleoprotein complex. Colocalizes with RISC-loading complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, 3'-UTR-mediated mRNA stabilization, MAPK cascade, cellular response to epidermal growth factor stimulus, cellular response to fibroblast growth factor stimulus, cellular response to glucocorticoid stimulus, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to lipopolysaccharide, cellular response to tumor necrosis factor, mRNA catabolic process, mRNA transport, miRNA-mediated gene silencing by inhibition of translation, negative regulation of 3'-UTR-mediated mRNA stabilization, negative regulation of cytokine production involved in inflammatory response, negative regulation of erythrocyte differentiation, negative regulation of interleukin-2 production, negative regulation of polynucleotide adenylyltransferase activity, negative regulation of transcription by RNA polymerase II, negative regulation of viral transcription, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, nuclear-transcribed mRNA catabolic process, deadenylation-independent decay, nuclear-transcribed mRNA poly(A) tail shortening, p38MAPK cascade, positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA, positive regulation of fat cell differentiation, positive regulation of intracellular mRNA localization, positive regulation of miRNA-mediated gene silencing, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, regulation of keratinocyte apoptotic process, regulation of keratinocyte differentiation, regulation of keratinocyte proliferation, regulation of mRNA stability, regulation of tumor necrosis factor production, regulatory ncRNA-mediated gene silencing, response to starvation, response to wounding; MF: 14-3-3 protein binding, C-C chemokine binding, DNA binding, RNA binding, RNA polymerase binding, enzyme binding, heat shock protein binding, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, mRNA binding, metal ion binding, protein binding, protein kinase binding, protein-RNA sequence-specific adaptor activity, protein-containing complex binding, zinc ion binding; CC: CCR4-NOT complex, P-body, cytoplasm, cytoplasmic stress granule, cytosol, exosome (RNase complex), nucleus, ribonucleoprotein complex
Pathways: ErbB1 downstream signaling, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Metabolism of RNA, Pre-implantation embryo, Regulation of mRNA stability by proteins that bind AU-rich elements, Spinal Cord Injury, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
UniProt: P26651
Entrez ID: 7538
|
Does Knockout of PSMA1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
PSMA1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PSMA1 (proteasome 20S subunit alpha 1)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009].
Gene Ontology: BP: immune system process, negative regulation of inflammatory response to antigenic stimulus, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: lipopolysaccharide binding, protein binding; CC: centrosome, cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), proteasome complex
UniProt: P25786
Entrez ID: 5682
|
Does Knockout of CCL28 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
CCL28
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: CCL28 (C-C motif chemokine ligand 28)
Type: protein-coding
Summary: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cell chemotaxis, cellular response to lipopolysaccharide, chemotaxis, cytolysis in another organism, immune response, inflammatory response, killing of cells of another organism, negative regulation of leukocyte tethering or rolling, neutrophil chemotaxis, positive regulation of cell-matrix adhesion, positive regulation of cytosolic calcium ion concentration, response to nutrient, signal transduction; MF: CXCR chemokine receptor binding, chemokine activity, chemokine receptor binding, cytokine activity, protein binding; CC: extracellular exosome, extracellular region, extracellular space, secretory granule
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Homo sapiens (human), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Intestinal immune network for IgA production - Homo sapiens (human), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: Q9NRJ3
Entrez ID: 56477
|
Does Knockout of TRAV3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
TRAV3
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TRAV3 (T cell receptor alpha variable 3)
Type: other
Summary: T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]
Gene Ontology: BP: adaptive immune response, immune system process; CC: T cell receptor complex, membrane, plasma membrane
Pathways:
UniProt:
Entrez ID: 28690
|
Does Knockout of TMEM132D in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
TMEM132D
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: TMEM132D (transmembrane protein 132D)
Type: protein-coding
Summary: Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: membrane
Pathways:
UniProt: Q14C87
Entrez ID: 121256
|
Does Knockout of ZNF75D in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
ZNF75D
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ZNF75D (zinc finger protein 75D)
Type: protein-coding
Summary: This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: P51815
Entrez ID: 7626
|
Does Knockout of GSTM5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
GSTM5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: GSTM5 (glutathione S-transferase mu 5)
Type: protein-coding
Summary: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: glutathione metabolic process; MF: glutathione transferase activity, identical protein binding, protein binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Biological oxidations, Chemical carcinogenesis - Homo sapiens (human), Drug metabolism - cytochrome P450 - Homo sapiens (human), Drug metabolism - other enzymes - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), Glutathione conjugation, Glutathione metabolism - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human), Metapathway biotransformation Phase I and II, NRF2 pathway, Nuclear Receptors Meta-Pathway, Pathways in cancer - Homo sapiens (human), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: P46439
Entrez ID: 2949
|
Does Knockout of DEK in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
DEK
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: DEK (DEK proto-oncogene)
Type: protein-coding
Summary: This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, regulation of double-strand break repair, regulation of double-strand break repair via nonhomologous end joining, regulation of transcription by RNA polymerase II, signal transduction, transcription by RNA polymerase II, viral genome replication; MF: DNA binding, RNA binding, histone binding, protein binding; CC: B-WICH complex, contractile muscle fiber, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Developmental Biology, Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, IL-18 signaling pathway, Positive epigenetic regulation of rRNA expression, RNA Polymerase II Transcription, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Transcriptional regulation of granulopoiesis
UniProt: P35659
Entrez ID: 7913
|
Does Knockout of ZNF468 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
ZNF468
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: ZNF468 (zinc finger protein 468)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of macromolecule biosynthetic process, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q5VIY5
Entrez ID: 90333
|
Does Knockout of PKNOX2 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
PKNOX2
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: PKNOX2 (PBX/knotted 1 homeobox 2)
Type: protein-coding
Summary: Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009].
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, actin filament binding, actin monomer binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: actin cytoskeleton, cytoplasm, intercellular bridge, microtubule cytoskeleton, nucleoplasm, nucleus
Pathways:
UniProt: Q96KN3
Entrez ID: 63876
|
Does Knockout of SDHD in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
SDHD
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SDHD (succinate dehydrogenase complex subunit D)
Type: protein-coding
Summary: This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: cellular response to hypoxia, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, regulation of catecholamine secretion, tricarboxylic acid cycle; MF: electron transfer activity, heme binding, metal ion binding, protein binding, succinate dehydrogenase (quinone) activity, ubiquinone binding; CC: membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion, respiratory chain complex II (succinate dehydrogenase)
Pathways: 2-ketoglutarate dehydrogenase complex deficiency, Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Citrate cycle (TCA cycle) - Homo sapiens (human), Citric Acid Cycle, Citric acid cycle (TCA cycle), Congenital lactic acidosis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Fumarase deficiency, Glutaminolysis and Cancer, Huntington disease - Homo sapiens (human), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial CII Assembly, Mitochondrial Electron Transport Chain, Mitochondrial complex II deficiency, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Pyruvate dehydrogenase deficiency (E2), Pyruvate dehydrogenase deficiency (E3), Respiratory electron transport, TCA Cycle (aka Krebs or citric acid cycle), TCA cycle, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate, Thermogenesis - Homo sapiens (human), Warburg Effect, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: O14521
Entrez ID: 6392
|
Does Knockout of CFB in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
CFB
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: CFB (complement factor B)
Type: protein-coding
Summary: This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: activation of membrane attack complex, complement activation, complement activation, alternative pathway, immune system process, innate immune response, killing of cells of another organism, pre-B cell differentiation, protein maturation, proteolysis, response to bacterium; MF: complement binding, hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: blood microparticle, cell surface, extracellular exosome, extracellular region, extracellular space, plasma membrane, symbiont cell surface
Pathways: Activation of C3 and C5, Alternative complement activation, Complement Activation, Complement and Coagulation Cascades, Complement and coagulation cascades - Homo sapiens (human), Complement cascade, Complement system, Coronavirus disease - COVID-19 - Homo sapiens (human), Immune System, Initial triggering of complement, Innate Immune System, Regulation of Complement cascade, Staphylococcus aureus infection - Homo sapiens (human)
UniProt: P00751
Entrez ID: 629
|
Does Knockout of MAU2 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
MAU2
|
response to virus
|
Hepatoma Cell Line
|
Gene: MAU2 (MAU2 sister chromatid cohesion factor)
Type: protein-coding
Summary: Enables protein N-terminus binding activity. Involved in cohesin loading and maintenance of mitotic sister chromatid cohesion. Located in chromatin and nuclear body. Part of Scc2-Scc4 cohesin loading complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, chromosome segregation, maintenance of mitotic sister chromatid cohesion, mitotic sister chromatid cohesion; MF: cohesin loader activity, protein binding; CC: SMC loading complex, Scc2-Scc4 cohesin loading complex, chromatin, chromosome, nuclear body, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cohesin Loading onto Chromatin, M Phase, Mitotic Telophase/Cytokinesis
UniProt: Q9Y6X3
Entrez ID: 23383
|
Does Knockout of RIPK3 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
RIPK3
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: RIPK3 (receptor interacting serine/threonine kinase 3)
Type: protein-coding
Summary: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell differentiation in thymus, T cell homeostasis, activation of protein kinase activity, amyloid fibril formation, apoptotic process, apoptotic signaling pathway, cellular response to hydrogen peroxide, defense response to virus, execution phase of necroptosis, lymph node development, necroptotic process, necroptotic signaling pathway, non-canonical NF-kappaB signal transduction, positive regulation of DNA-templated transcription, positive regulation of NF-kappaB transcription factor activity, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of metabolic process, positive regulation of necroptotic process, positive regulation of reactive oxygen species metabolic process, programmed cell death, programmed necrotic cell death, protein modification process, reactive oxygen species metabolic process, regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation, regulation of T cell mediated cytotoxicity, regulation of activated T cell proliferation, regulation of activation-induced cell death of T cells, regulation of adaptive immune response, regulation of apoptotic process, regulation of gene expression, regulation of reactive oxygen species metabolic process, regulation of type II interferon production, signal transduction, spleen development, thymus development; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transcription coactivator activity, transferase activity; CC: cytoplasm, cytosol, nucleus, protein-containing complex
Pathways: Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , Defective RIPK1-mediated regulated necrosis, Disease, Diseases of programmed cell death, IKK complex recruitment mediated by RIP1, Immune System, Infectious disease, Innate Immune System, Ion channel transport, Microbial modulation of RIPK1-mediated regulated necrosis, MyD88-independent TLR4 cascade , NOD-like receptor signaling pathway - Homo sapiens (human), Nanoparticle triggered regulated necrosis, Necroptosis - Homo sapiens (human), Programmed Cell Death, RIP-mediated NFkB activation via ZBP1, RIPK1-mediated regulated necrosis, Regulated Necrosis, Regulation of necroptotic cell death, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 activates/modulates innate immune responses, SARS-CoV-1-host interactions, SARS-CoV-1-mediated effects on programmed cell death, Salmonella infection - Homo sapiens (human), Stimuli-sensing channels, TICAM1, RIP1-mediated IKK complex recruitment, TLR3-mediated TICAM1-dependent programmed cell death, TNF signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, TNFalpha, TRIF (TICAM1)-mediated TLR4 signaling , TRIF-mediated programmed cell death, TRP channels, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Transport of small molecules, Viral Infection Pathways, ZBP1(DAI) mediated induction of type I IFNs
UniProt: Q9Y572
Entrez ID: 11035
|
Does Knockout of LARGE2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
LARGE2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: LARGE2 (LARGE xylosyl- and glucuronyltransferase 2)
Type: protein-coding
Summary: Predicted to enable dystroglycan binding activity; glucuronosyltransferase activity; and xylosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: muscle cell cellular homeostasis, protein O-linked glycosylation, protein O-linked glycosylation via mannose, protein glycosylation; MF: UDP-xylosyltransferase activity, catalytic activity, glucuronosyltransferase activity, glycosyltransferase activity, manganese ion binding, metal ion binding, protein binding, transferase activity, xylosyltransferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: DAG1 glycosylations, Mannose type O-glycan biosynthesis - Homo sapiens (human), Matriglycan biosynthesis on DAG1, Metabolism of proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8N3Y3
Entrez ID: 120071
|
Does Knockout of CDC27 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
CDC27
|
cell proliferation
|
Cancer Cell Line
|
Gene: CDC27 (cell division cycle 27)
Type: protein-coding
Summary: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, metaphase/anaphase transition of mitotic cell cycle, neuron projection development, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; MF: protein binding, protein phosphatase binding; CC: anaphase-promoting complex, centrosome, cytoplasm, cytoskeleton, cytosol, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: Cell cycle, Cell cycle - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), TGF_beta_Receptor, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: P30260
Entrez ID: 996
|
Does Knockout of NCBP1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
NCBP1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: NCBP1 (nuclear cap binding protein subunit 1)
Type: protein-coding
Summary: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 7-methylguanosine mRNA capping, RNA catabolic process, RNA metabolic process, RNA splicing, alternative mRNA splicing, via spliceosome, cap-dependent translational initiation, defense response to virus, histone mRNA metabolic process, mRNA 3'-end processing, mRNA export from nucleus, mRNA metabolic process, mRNA processing, mRNA splicing, via spliceosome, mRNA transcription by RNA polymerase II, mRNA transport, miRNA-mediated post-transcriptional gene silencing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of RNA binding, positive regulation of cell growth, positive regulation of mRNA 3'-end processing, positive regulation of mRNA splicing, via spliceosome, positive regulation of transcription elongation by RNA polymerase II, primary miRNA processing, regulation of mRNA processing, regulation of translation, regulation of translational initiation, regulatory ncRNA-mediated gene silencing, regulatory ncRNA-mediated post-transcriptional gene silencing, snRNA export from nucleus, spliceosomal complex assembly; MF: RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, mRNA binding, molecular adaptor activity, protein binding; CC: RNA cap binding complex, cytoplasm, cytosol, mitochondrion, nuclear cap binding complex, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: 3q29 copy number variation syndrome, Abortive elongation of HIV-1 transcript in the absence of Tat, Amyotrophic lateral sclerosis - Homo sapiens (human), Axon guidance, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Metabolism of non-coding RNA, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear RNA decay, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Termination, RNA polymerase II transcribes snRNA genes, RNA transport - Homo sapiens (human), Regulation of expression of SLITs and ROBOs, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Spliceosome - Homo sapiens (human), Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, mRNA 3'-end processing, mRNA Capping, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, mRNA surveillance pathway - Homo sapiens (human), snRNP Assembly
UniProt: Q09161
Entrez ID: 4686
|
Does Knockout of DBF4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
DBF4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: DBF4 (DBF4-CDC7 kinase regulatory subunit)
Type: protein-coding
Summary: Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA replication, G1/S transition of mitotic cell cycle, positive regulation of nuclear cell cycle DNA replication, regulation of cell cycle phase transition; MF: enzyme activator activity, metal ion binding, nucleic acid binding, protein binding, protein serine/threonine kinase activator activity, zinc ion binding; CC: Dbf4-dependent protein kinase complex, nuclear body, nucleoplasm, nucleus
Pathways: Cell cycle, Cell cycle - Homo sapiens (human), DNA Replication
UniProt: Q9UBU7
Entrez ID: 10926
|
Does Knockout of NECTIN4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
NECTIN4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: NECTIN4 (nectin cell adhesion molecule 4)
Type: protein-coding
Summary: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011].
Gene Ontology: BP: cell adhesion, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of natural killer cell mediated cytotoxicity, signal transduction, symbiont entry into host cell; MF: cell adhesion mediator activity, identical protein binding, protein binding, receptor ligand activity, virus receptor activity; CC: adherens junction, anchoring junction, extracellular exosome, extracellular region, membrane, plasma membrane
Pathways: Adherens junction - Homo sapiens (human), Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Nectin/Necl trans heterodimerization
UniProt: Q96NY8
Entrez ID: 81607
|
Does Knockout of PRR3 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
PRR3
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: PRR3 (proline rich 3)
Type: protein-coding
Summary: Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: P79522
Entrez ID: 80742
|
Does Knockout of SUPT16H in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
SUPT16H
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit)
Type: protein-coding
Summary: Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, nucleosome assembly, nucleosome disassembly, positive regulation of DNA-templated transcription, elongation, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: RNA binding, nucleosome binding, protein binding; CC: FACT complex, chromosome, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Disease, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV elongation arrest and recovery, Infectious disease, Late Phase of HIV Life Cycle, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcriptional Regulation by TP53, Viral Infection Pathways
UniProt: Q9Y5B9
Entrez ID: 11198
|
Does Knockout of CTRL in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
CTRL
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CTRL (chymotrypsin like)
Type: protein-coding
Summary: This gene encodes a serine-type endopeptidase with chymotrypsin- and elastase-2-like activities. The gene encoding this zymogen is expressed specifically in the pancreas and likely functions as a digestive enzyme. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: protein catabolic process, proteolysis; MF: hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Pancreatic Acinar Cells, Pancreatic secretion - Homo sapiens (human), Protein digestion and absorption - Homo sapiens (human)
UniProt: P40313
Entrez ID: 1506
|
Does Knockout of GTF2H2C_2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
GTF2H2C_2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GTF2H2C_2 (GTF2H2 family member C, copy 2)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in nucleotide-excision repair and regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: metal ion binding, protein binding, zinc ion binding; CC: nuclear speck, nucleus, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Homo sapiens (human), Nucleotide excision repair - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human)
UniProt: Q6P1K8
Entrez ID: 730394
|
Does Knockout of STX4 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
STX4
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: STX4 (syntaxin 4)
Type: protein-coding
Summary: Enables sphingomyelin phosphodiesterase activator activity. Involved in several processes, including cornified envelope assembly; positive regulation of immune effector process; and positive regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lamellipodium. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: SNARE complex assembly, cellular response to oxidative stress, cellular response to type II interferon, cornified envelope assembly, exocytosis, intracellular protein transport, long-term synaptic potentiation, membrane organization, neurotransmitter transport, organelle fusion, positive regulation of catalytic activity, positive regulation of cell adhesion, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of chemotaxis, positive regulation of eosinophil degranulation, positive regulation of immunoglobulin production, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of protein localization to cell surface, positive regulation of protein localization to plasma membrane, protein localization to cell surface, regulation of exocytosis, regulation of extrinsic apoptotic signaling pathway via death domain receptors, regulation of postsynaptic membrane neurotransmitter receptor levels, sensory perception of sound, vesicle docking, vesicle fusion, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding, protein binding, sphingomyelin phosphodiesterase activator activity; CC: SNARE complex, Schaffer collateral - CA1 synapse, basolateral plasma membrane, cell projection, cell surface, cytoplasm, cytosol, dendritic spine, endomembrane system, endosome, extracellular exosome, extracellular space, glutamatergic synapse, lamellipodium, lateral loop, membrane, myelin sheath adaxonal region, neuron projection, neuron projection membrane, perinuclear region of cytoplasm, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, postsynapse, somatodendritic compartment, specific granule, stereocilium, storage vacuole, synapse, trans-Golgi network, vacuole
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Disinhibition of SNARE formation, EGFR1, ER-Phagosome pathway, Hemostasis, Immune System, Insulin Signaling, Insulin-mediated glucose transport, Membrane Trafficking, Other interleukin signaling, Platelet activation, signaling and aggregation, Response to elevated platelet cytosolic Ca2+, SNARE interactions in vesicular transport - Homo sapiens (human), Signaling by Interleukins, Stabilization and expansion of the E-cadherin adherens junction, Translocation of SLC2A4 (GLUT4) to the plasma membrane, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q12846
Entrez ID: 6810
|
Does Knockout of ZFP69B in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
ZFP69B
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ZFP69B (ZFP69 zinc finger protein B)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Golgi organization. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Golgi organization, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nuclear lumen, nucleolus, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9UJL9
Entrez ID: 65243
|
Does Knockout of GNL3L in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
GNL3L
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: GNL3L (G protein nucleolar 3 like)
Type: protein-coding
Summary: The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010].
Gene Ontology: BP: negative regulation of protein sumoylation, negative regulation of protein ubiquitination, negative regulation of telomere maintenance via telomerase, positive regulation of protein localization to chromosome, telomeric region, positive regulation of protein-containing complex assembly, regulation of protein stability, ribosome biogenesis; MF: GTP binding, RNA binding, nucleotide binding, protein binding; CC: cytosol, membrane, nucleolus, nucleoplasm, nucleus, telomerase holoenzyme complex
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q9NVN8
Entrez ID: 54552
|
Does Knockout of TGFBRAP1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
TGFBRAP1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: TGFBRAP1 (transforming growth factor beta receptor associated protein 1)
Type: protein-coding
Summary: This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016].
Gene Ontology: BP: autophagy, endosomal vesicle fusion, endosome to lysosome transport, intracellular protein transport, protein transport, regulation of DNA-templated transcription, regulation of SNARE complex assembly, signal transduction, transforming growth factor beta receptor signaling pathway, vesicle-mediated transport; MF: SMAD binding, protein binding, transforming growth factor beta receptor binding; CC: CORVET complex, cytoplasm, early endosome, endomembrane system, endosome, membrane
Pathways: Regulation of cytoplasmic and nuclear SMAD2/3 signaling, TGF-beta receptor signaling
UniProt: Q8WUH2
Entrez ID: 9392
|
Does Knockout of TMEM61 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
TMEM61
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TMEM61 (transmembrane protein 61)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8N0U2
Entrez ID: 199964
|
Does Knockout of UBR4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
UBR4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: UBR4 (ubiquitin protein ligase E3 component n-recognin 4)
Type: protein-coding
Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: HRI-mediated signaling, cellular response to stress, cytoplasm protein quality control, cytoplasm protein quality control by the ubiquitin-proteasome system, cytoplasmic translation, endosome organization, fatty acid biosynthetic process, negative regulation of HRI-mediated signaling, negative regulation of fatty acid biosynthetic process, positive regulation of autophagy, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins, protein stabilization, protein targeting to vacuole involved in autophagy, protein ubiquitination, response to oxidative stress, translational initiation, type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the N-end rule pathway; MF: calmodulin binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytoskeleton, cytosol, endosome, ficolin-1-rich granule membrane, membrane, nucleus, plasma membrane, specific granule membrane, tertiary granule membrane
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Neutrophil degranulation, Viral carcinogenesis - Homo sapiens (human)
UniProt: Q5T4S7
Entrez ID: 23352
|
Does Knockout of RASEF in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
RASEF
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: RASEF (RAS and EF-hand domain containing)
Type: protein-coding
Summary: This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential role as tumor suppressor has been indicated for this gene. [provided by RefSeq, Nov 2012].
Gene Ontology: MF: GDP binding, GTP binding, GTPase activity, calcium ion binding, identical protein binding, metal ion binding, nucleotide binding; CC: cytoplasm, cytosol, perinuclear region of cytoplasm
Pathways:
UniProt: Q8IZ41
Entrez ID: 158158
|
Does Knockout of KATNAL2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
KATNAL2
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: KATNAL2 (katanin catalytic subunit A1 like 2)
Type: protein-coding
Summary: Predicted to enable microtubule-severing ATPase activity. Predicted to be involved in cytoplasmic microtubule organization. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic spindle organization, microtubule severing; MF: ATP binding, ATP hydrolysis activity, isomerase activity, microtubule binding, microtubule severing ATPase activity, nucleotide binding, protein binding; CC: cytoplasm, cytoskeleton, katanin complex, microtubule, microtubule cytoskeleton, spindle, spindle pole
Pathways: VEGFA-VEGFR2 Signaling Pathway
UniProt: Q8IYT4
Entrez ID: 83473
|
Does Knockout of U2SURP in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
U2SURP
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: U2SURP (U2 snRNP associated SURP domain containing)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in RNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, nucleic acid binding, protein binding; CC: U2 snRNP, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O15042
Entrez ID: 23350
|
Does Knockout of SSRP1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
SSRP1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SSRP1 (structure specific recognition protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, nucleosome assembly, nucleosome disassembly, regulation of chromatin organization; MF: DNA binding, RNA binding, chromatin binding, histone binding, nucleosome binding, protein binding; CC: FACT complex, chromosome, nucleolus, nucleoplasm, nucleus
Pathways: Disease, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV elongation arrest and recovery, Infectious disease, Late Phase of HIV Life Cycle, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcriptional Regulation by TP53, Validated transcriptional targets of TAp63 isoforms, Viral Infection Pathways
UniProt: Q08945
Entrez ID: 6749
|
Does Knockout of TRPV3 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
TRPV3
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: TRPV3 (transient receptor potential cation channel subfamily V member 3)
Type: protein-coding
Summary: This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: actin filament organization, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of hair cycle, osmosensory signaling pathway, positive regulation of calcium ion import, response to temperature stimulus, sodium ion transmembrane transport, transmembrane transport; MF: calcium channel activity, identical protein binding, metal ion binding, monoatomic cation channel activity, monoatomic ion channel activity, protein binding, sodium channel activity; CC: cilium, cytoplasm, lysosome, membrane, plasma membrane, receptor complex
Pathways: Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Ion channel transport, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q8NET8
Entrez ID: 162514
|
Does Knockout of ZNF644 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
ZNF644
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ZNF644 (zinc finger protein 644)
Type: protein-coding
Summary: The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, transcription corepressor binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q9H582
Entrez ID: 84146
|
Does Knockout of UBE2I in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
UBE2I
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: UBE2I (ubiquitin conjugating enzyme E2 I)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell division, chromosome segregation, mitotic nuclear membrane reassembly, modulation of chemical synaptic transmission, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, nuclear export, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, protein modification process, protein sumoylation, ubiquitin-dependent protein catabolic process; MF: ATP binding, HLH domain binding, RING-like zinc finger domain binding, RNA binding, SUMO conjugating enzyme activity, SUMO transferase activity, enzyme binding, nucleotide binding, protein binding, small protein activating enzyme binding, transcription coregulator binding, transcription factor binding, transferase activity; CC: PML body, SUMO ligase complex, Schaffer collateral - CA1 synapse, cytoplasm, cytosol, glutamatergic synapse, nuclear body, nuclear envelope, nuclear pore, nucleoplasm, nucleus, perinuclear region of cytoplasm, postsynaptic cytosol, presynaptic cytosol, synaptonemal complex, transferase complex
Pathways: Androgen receptor signaling pathway, AndrogenReceptor, Antiviral mechanism by IFN-stimulated genes, C-MYB transcription factor network, Cell Cycle, Cell Cycle, Mitotic, Coregulation of Androgen receptor activity, Cytokine Signaling in Immune system, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Developmental Biology, Disease, Epigenetic regulation of gene expression, Formation of Incision Complex in GG-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Immune System, Infectious disease, Interferon Signaling, Late SARS-CoV-2 Infection Events, M Phase, MITF-M-regulated melanocyte development, Maturation of nucleoprotein, Meiosis, Meiotic synapsis, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, MicroRNAs in cancer - Homo sapiens (human), Mitotic Anaphase, Mitotic Metaphase and Anaphase, NF-kappa B signaling pathway - Homo sapiens (human), Negative regulation of activity of TFAP2 (AP-2) family transcription factors, Nuclear Envelope (NE) Reassembly, Nucleotide Excision Repair, PKR-mediated signaling, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing and activation of SUMO, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, RNA transport - Homo sapiens (human), Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of cytoplasmic and nuclear SMAD2/3 signaling, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins, Reproduction, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 targets host intracellular signalling and regulatory pathways, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SUMO E3 ligases SUMOylate target proteins, SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA methylation proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of immune response proteins, SUMOylation of intracellular receptors, SUMOylation of nuclear envelope proteins, SUMOylation of transcription cofactors, SUMOylation of transcription factors, SUMOylation of ubiquitinylation proteins, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TGF-beta Signaling Pathway, TGF_beta_Receptor, TNFalpha, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Translation of Structural Proteins, Ubiquitin mediated proteolysis - Homo sapiens (human), Viral Infection Pathways, Vitamin D (calciferol) metabolism, basic mechanisms of sumoylation, er associated degradation (erad) pathway, regulation of transcriptional activity by pml
UniProt: P63279
Entrez ID: 7329
|
Does Knockout of ETV7 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
ETV7
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: ETV7 (ETS variant transcription factor 7)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011].
Gene Ontology: BP: animal organ morphogenesis, cell differentiation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: Q9Y603
Entrez ID: 51513
|
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