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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of ELP2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
ELP2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ELP2 (elongator acetyltransferase complex subunit 2)
Type: protein-coding
Summary: The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016].
Gene Ontology: BP: regulation of receptor signaling pathway via JAK-STAT, regulation of transcription by RNA polymerase II, regulation of translation, tRNA processing, tRNA wobble uridine modification, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, protein kinase binding; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q6IA86
Entrez ID: 55250
|
Does Knockout of TMEFF1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
TMEFF1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: TMEFF1 (transmembrane protein with EGF like and two follistatin like domains 1)
Type: protein-coding
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in animal organ morphogenesis; neuron projection development; and tissue development. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: host-mediated suppression of symbiont invasion, symbiont entry into host cell; CC: membrane, plasma membrane
Pathways:
UniProt: Q8IYR6
Entrez ID: 8577
|
Does Knockout of PLEKHA1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
PLEKHA1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: PLEKHA1 (pleckstrin homology domain containing A1)
Type: protein-coding
Summary: This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010].
Gene Ontology: BP: B cell receptor signaling pathway, Leydig cell differentiation, androgen metabolic process, cellular response to hydrogen peroxide, establishment of protein localization, estrogen metabolic process, face morphogenesis, female gonad development, luteinization, multicellular organism growth, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol 3-kinase/protein kinase B signal transduction, platelet-derived growth factor receptor signaling pathway, post-embryonic development, roof of mouth development, ruffle organization, skeletal system morphogenesis, spermatogenesis; MF: PDZ domain binding, lipid binding, phosphatidylinositol-3,4-bisphosphate binding, phospholipid binding, protein binding; CC: cytoplasm, cytosol, extracellular exosome, membrane, nucleoplasm, nucleus, plasma membrane, ruffle membrane
Pathways: BCR, Class I PI3K signaling events, Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism, Synthesis of PIPs at the plasma membrane
UniProt: Q9HB21
Entrez ID: 59338
|
Does Knockout of SMC4 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
SMC4
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: SMC4 (structural maintenance of chromosomes 4)
Type: protein-coding
Summary: This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016].
Gene Ontology: BP: cell division, chromosome condensation, chromosome organization, kinetochore organization, meiotic chromosome condensation, meiotic chromosome segregation, mitotic chromosome condensation, mitotic sister chromatid segregation, nuclear chromosome segregation, nuclear division, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation; MF: ATP binding, ATP hydrolysis activity, chromatin binding, nucleotide binding, protein binding, single-stranded DNA binding; CC: chromosome, chromosome, centromeric region, condensed nuclear chromosome, condensin complex, cytoplasm, cytosol, nuclear lumen, nuclear speck, nucleoplasm, nucleus
Pathways: Aurora B signaling, Cell Cycle, Cell Cycle, Mitotic, Ciliary landscape, Condensation of Prometaphase Chromosomes, Condensation of Prophase Chromosomes, M Phase, Mitotic Prometaphase, Mitotic Prophase
UniProt: Q9NTJ3
Entrez ID: 10051
|
Does Knockout of TFAP2C in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
TFAP2C
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: TFAP2C (transcription factor AP-2 gamma)
Type: protein-coding
Summary: The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell-cell signaling, cerebral cortex development, dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis, epithelial cell differentiation, epithelial cell proliferation involved in mammary gland duct elongation, forebrain neuron fate commitment, germ-line stem cell population maintenance, hair follicle development, inner cell mass cell differentiation, keratinocyte development, male gonad development, morula formation, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell population proliferation, regulation of epidermis development, regulation of transcription by RNA polymerase II, sebaceous gland development, skin development, somatic stem cell population maintenance, stem cell differentiation, stem cell population maintenance, transcription by RNA polymerase II, trophectodermal cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Activation of the TFAP2 (AP-2) family of transcription factors, Ciliary landscape, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Developmental Lineage of Mammary Stem Cells, Developmental Lineages of the Mammary Gland, Ectoderm Differentiation, Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Negative regulation of activity of TFAP2 (AP-2) family transcription factors, Post-translational protein modification, RNA Polymerase II Transcription, Reproduction, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription factors, Specification of primordial germ cells, Specification of the neural plate border, TFAP2 (AP-2) family regulates transcription of cell cycle factors, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, TFAP2 (AP-2) family regulates transcription of other transcription factors, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Validated transcriptional targets of TAp63 isoforms
UniProt: Q92754
Entrez ID: 7022
|
Does Knockout of DDX56 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
DDX56
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: DDX56 (DEAD-box helicase 56)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: cytoplasmic pattern recognition receptor signaling pathway, defense response to virus, host-mediated perturbation of viral RNA genome replication, negative regulation of type I interferon production, positive regulation of neuron projection development, protein import into nucleus, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA stem-loop binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding, protein sequestering activity; CC: cytosol, membrane, nucleolus, nucleus
Pathways:
UniProt: Q9NY93
Entrez ID: 54606
|
Does Knockout of SLC30A5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
SLC30A5
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SLC30A5 (solute carrier family 30 member 5)
Type: protein-coding
Summary: This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: GPI anchor biosynthetic process, cobalt ion transport, insulin processing, intracellular zinc ion homeostasis, monoatomic cation transport, monoatomic ion transport, response to zinc ion, transmembrane transport, zinc ion import across plasma membrane, zinc ion import into Golgi lumen, zinc ion import into organelle, zinc ion transmembrane transport, zinc ion transport; MF: antiporter activity, cadmium ion transmembrane transporter activity, metal ion binding, monoatomic cation transmembrane transporter activity, protein binding, zinc efflux transmembrane transporter activity, zinc ion transmembrane transporter activity, zinc:proton antiporter activity; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi cis cisterna membrane, Golgi cisterna membrane, Golgi membrane, apical plasma membrane, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus, nucleoplasm, plasma membrane, secretory granule, secretory granule membrane, trans-Golgi network membrane, transport vesicle membrane
Pathways: Insulin processing, Metabolism of proteins, Metal ion SLC transporters, Peptide hormone metabolism, SLC-mediated transmembrane transport, Transport of small molecules, Zinc efflux and compartmentalization by the SLC30 family, Zinc homeostasis, Zinc transporters
UniProt: Q8TAD4
Entrez ID: 64924
|
Does Knockout of WDR48 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
WDR48
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: WDR48 (WD repeat domain 48)
Type: protein-coding
Summary: The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is ubiquitinated in response to DNA damage. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: DNA damage response, DNA repair, cell surface receptor signaling pathway via JAK-STAT, double-strand break repair via homologous recombination, embryonic organ development, homeostasis of number of cells, male gonad development, multicellular organism growth, positive regulation of double-strand break repair via homologous recombination, positive regulation of epithelial cell proliferation, positive regulation of receptor signaling pathway via JAK-STAT, regulation of macromolecule metabolic process, regulation of primary metabolic process, regulation of protein monoubiquitination, seminiferous tubule development, single fertilization, skeletal system morphogenesis, skin development, spermatogenesis; MF: DNA binding, deubiquitinase activator activity, double-stranded DNA binding, protein binding, single-stranded DNA binding, ubiquitin binding; CC: cytoplasm, cytosol, endosome, late endosome, lysosome, nucleoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Repair, DNA Repair Pathways Full Network, Deubiquitination, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Fanconi Anemia Pathway, Fanconi anemia pathway, Fanconi anemia pathway - Homo sapiens (human), Metabolism of proteins, Post-translational protein modification, Recognition of DNA damage by PCNA-containing replication complex, Signaling by PDGFR in disease, Signaling by cytosolic PDGFRA and PDGFRB fusion proteins, Ub-specific processing proteases
UniProt: Q8TAF3
Entrez ID: 57599
|
Does Knockout of TMEM127 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
TMEM127
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TMEM127 (transmembrane protein 127)
Type: protein-coding
Summary: This gene encodes a transmembrane protein with four predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2022].
Gene Ontology: BP: endosome organization, negative regulation of TOR signaling, negative regulation of cell population proliferation, regulation of TOR signaling; CC: cytoplasm, early endosome, membrane, plasma membrane
Pathways:
UniProt: O75204
Entrez ID: 55654
|
Does Knockout of FNTB in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
FNTB
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: FNTB (farnesyltransferase, CAAX box, subunit beta)
Type: protein-coding
Summary: Enables zinc ion binding activity. Contributes to protein farnesyltransferase activity. Involved in protein farnesylation. Part of microtubule associated complex and protein farnesyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: lipid metabolic process, positive regulation of cell cycle, positive regulation of cell population proliferation, protein farnesylation, regulation of microtubule-based movement; MF: acetyltransferase activator activity, catalytic activity, enzyme binding, metal ion binding, peptide binding, prenyltransferase activity, protein binding, protein farnesyltransferase activity, protein prenyltransferase activity, transferase activity, zinc ion binding; CC: cytosol, microtubule associated complex, protein farnesyltransferase complex
Pathways: Disease, Inactivation, recovery and regulation of the phototransduction cascade, Infectious disease, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Potential therapeutics for SARS, RAF/MAP kinase cascade, RAS processing, SARS-CoV Infections, Sensory Perception, Signal Transduction, Terpenoid backbone biosynthesis - Homo sapiens (human), The phototransduction cascade, Viral Infection Pathways, Visual phototransduction
UniProt: P49356
Entrez ID: 2342
|
Does Knockout of PROM1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
PROM1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: PROM1 (prominin 1)
Type: protein-coding
Summary: This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: camera-type eye photoreceptor cell differentiation, glomerular parietal epithelial cell differentiation, photoreceptor cell maintenance, podocyte differentiation, positive regulation of nephron tubule epithelial cell differentiation, retina layer formation, retina morphogenesis in camera-type eye; MF: actinin binding, cadherin binding, cholesterol binding, protein binding; CC: apical plasma membrane, cell projection, cell surface, cilium, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, extracellular space, membrane, microvillus, microvillus membrane, photoreceptor outer segment, photoreceptor outer segment membrane, plasma membrane, prominosome, vesicle
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Pancreatic Ductal Cells, Extracellular vesicle-mediated signaling in recipient cells, Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: O43490
Entrez ID: 8842
|
Does Knockout of INTS11 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
INTS11
|
cell proliferation
|
Cancer Cell Line
|
Gene: INTS11 (integrator complex subunit 11)
Type: protein-coding
Summary: The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, regulation of transcription elongation by RNA polymerase II, snRNA 3'-end processing, snRNA processing, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: RNA endonuclease activity, hydrolase activity, metal ion binding, protein binding; CC: INTAC complex, blood microparticle, cytoplasm, cytosol, integrator complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q5TA45
Entrez ID: 54973
|
Does Knockout of ELP4 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
ELP4
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ELP4 (elongator acetyltransferase complex subunit 4)
Type: protein-coding
Summary: This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: regulation of transcription by RNA polymerase II, regulation of translation, tRNA processing, tRNA wobble uridine modification; MF: phosphorylase kinase regulator activity, protein binding; CC: cytoplasm, elongator holoenzyme complex, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, Mesodermal commitment pathway
UniProt: Q96EB1
Entrez ID: 26610
|
Does Knockout of NCBP1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
NCBP1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: NCBP1 (nuclear cap binding protein subunit 1)
Type: protein-coding
Summary: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 7-methylguanosine mRNA capping, RNA catabolic process, RNA metabolic process, RNA splicing, alternative mRNA splicing, via spliceosome, cap-dependent translational initiation, defense response to virus, histone mRNA metabolic process, mRNA 3'-end processing, mRNA export from nucleus, mRNA metabolic process, mRNA processing, mRNA splicing, via spliceosome, mRNA transcription by RNA polymerase II, mRNA transport, miRNA-mediated post-transcriptional gene silencing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of RNA binding, positive regulation of cell growth, positive regulation of mRNA 3'-end processing, positive regulation of mRNA splicing, via spliceosome, positive regulation of transcription elongation by RNA polymerase II, primary miRNA processing, regulation of mRNA processing, regulation of translation, regulation of translational initiation, regulatory ncRNA-mediated gene silencing, regulatory ncRNA-mediated post-transcriptional gene silencing, snRNA export from nucleus, spliceosomal complex assembly; MF: RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, mRNA binding, molecular adaptor activity, protein binding; CC: RNA cap binding complex, cytoplasm, cytosol, mitochondrion, nuclear cap binding complex, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: 3q29 copy number variation syndrome, Abortive elongation of HIV-1 transcript in the absence of Tat, Amyotrophic lateral sclerosis - Homo sapiens (human), Axon guidance, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Metabolism of non-coding RNA, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear RNA decay, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Termination, RNA polymerase II transcribes snRNA genes, RNA transport - Homo sapiens (human), Regulation of expression of SLITs and ROBOs, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Spliceosome - Homo sapiens (human), Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, mRNA 3'-end processing, mRNA Capping, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, mRNA surveillance pathway - Homo sapiens (human), snRNP Assembly
UniProt: Q09161
Entrez ID: 4686
|
Does Knockout of EDN3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
EDN3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: EDN3 (endothelin 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: artery smooth muscle contraction, axon extension, axon guidance, blood circulation, blood vessel diameter maintenance, cell population proliferation, cell surface receptor signaling pathway, cell-cell signaling, establishment of localization in cell, intracellular calcium ion homeostasis, intracellular magnesium ion homeostasis, melanocyte differentiation, neural crest cell migration, neuron differentiation, neuron projection development, neutrophil chemotaxis, peptide hormone secretion, positive regulation of MAPK cascade, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of heart rate, positive regulation of hormone secretion, positive regulation of leukocyte chemotaxis, positive regulation of mitotic nuclear division, positive regulation of potassium ion transmembrane transport, positive regulation of smooth muscle contraction, potassium ion transmembrane transport, regulation of cell migration, regulation of developmental pigmentation, regulation of gene expression, regulation of systemic arterial blood pressure by endothelin, regulation of vasoconstriction, signal transduction, vasoconstriction, vein smooth muscle contraction; MF: endothelin B receptor binding, hormone activity, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Class A/1 (Rhodopsin-like receptors), Developmental Biology, Endothelins, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, MITF-M-regulated melanocyte development, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide ligand-binding receptors, Renin secretion - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Transcriptional and post-translational regulation of MITF-M expression and activity, Vascular smooth muscle contraction - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human)
UniProt: P14138
Entrez ID: 1908
|
Does Knockout of WDR74 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
WDR74
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: WDR74 (WD repeat domain 74)
Type: protein-coding
Summary: Involved in rRNA processing and ribosomal large subunit biogenesis. Located in nucleoplasm. Colocalizes with nuclear exosome (RNase complex) and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA metabolic process, blastocyst formation, rRNA processing, ribosomal large subunit biogenesis; CC: nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q6RFH5
Entrez ID: 54663
|
Does Knockout of C10orf71 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
C10orf71
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: C10orf71 (chromosome 10 open reading frame 71)
Type: protein-coding
Summary: Predicted to be involved in positive regulation of calcineurin-NFAT signaling cascade. Predicted to be located in Z disc. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cardiac muscle cell contraction, cardiac muscle cell differentiation, heart development, heart morphogenesis, positive regulation of calcineurin-NFAT signaling cascade; CC: Z disc, cytoplasm
Pathways:
UniProt: Q711Q0
Entrez ID: 118461
|
Does Knockout of PALB2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
PALB2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: PALB2 (partner and localizer of BRCA2)
Type: protein-coding
Summary: This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, animal organ morphogenesis, apoptotic process, double-strand break repair via homologous recombination, embryonic organ development, in utero embryonic development, inner cell mass cell proliferation, mesoderm development, multicellular organism growth, negative regulation of apoptotic process, post-anal tail morphogenesis, somitogenesis; MF: DNA binding, protein binding; CC: DNA repair complex, nuclear speck, nucleoplasm, nucleus, protein-containing complex
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Defective homologous recombination repair (HRR) due to BRCA1 loss of function, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Defective homologous recombination repair (HRR) due to PALB2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Fanconi anemia pathway, Fanconi anemia pathway - Homo sapiens (human), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to PALB2, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Post-translational protein modification, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
UniProt: Q86YC2
Entrez ID: 79728
|
Does Knockout of MBD3L4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
MBD3L4
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: MBD3L4 (methyl-CpG binding domain protein 3 like 4)
Type: protein-coding
Summary: This gene encodes a member of a family of proteins that are related to methyl-CpG-binding proteins but lack the methyl-CpG binding domain. There is no definitive support for transcription of this locus, and the transcript structure is inferred from other family members. [provided by RefSeq, Aug 2009].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, negative regulation of transcription by RNA polymerase II; CC: nucleus
Pathways:
UniProt: A6NDZ8
Entrez ID: 653656
|
Does Knockout of UTP20 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
UTP20
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: UTP20 (UTP20 small subunit processome component)
Type: protein-coding
Summary: UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009].
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of cell population proliferation, rRNA processing, ribosomal small subunit biogenesis; MF: RNA binding, protein binding; CC: 90S preribosome, cytoplasm, nucleolus, nucleoplasm, nucleus, plasma membrane, preribosome, small subunit precursor, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O75691
Entrez ID: 27340
|
Does Knockout of VMP1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
VMP1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: VMP1 (vacuole membrane protein 1)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: Golgi organization, autophagosome assembly, autophagosome membrane docking, autophagy, cell adhesion, cell junction assembly, cell-cell adhesion, embryo implantation, lipid transport, lipoprotein transport, mitochondrion-endoplasmic reticulum membrane tethering, organelle localization by membrane tethering, plasma membrane phospholipid scrambling, positive regulation of ATPase-coupled calcium transmembrane transporter activity; MF: phospholipid scramblase activity, protein binding; CC: autophagosome membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, nucleolus, phagophore assembly site, plasma membrane, vacuolar membrane, vacuole
Pathways: Autophagy - animal - Homo sapiens (human), Nanoparticle triggered autophagic cell death
UniProt: Q96GC9
Entrez ID: 81671
|
Does Knockout of C6orf47 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
C6orf47
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: C6orf47 (chromosome 6 open reading frame 47)
Type: protein-coding
Summary: Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: O95873
Entrez ID: 57827
|
Does Knockout of DNALI1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
DNALI1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: DNALI1 (dynein axonemal light intermediate chain 1)
Type: protein-coding
Summary: This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: sperm flagellum assembly; MF: dynein heavy chain binding, protein binding; CC: 9+2 motile cilium, axoneme, cell projection, ciliary base, cilium, cytoplasm, dynein axonemal particle, dynein complex, filopodium, intercellular bridge, microtubule cytoskeleton, mitotic spindle, motile cilium, nucleoplasm, sperm flagellum
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
UniProt: O14645
Entrez ID: 7802
|
Does Knockout of TIPRL in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
TIPRL
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: TIPRL (TOR signaling pathway regulator)
Type: protein-coding
Summary: TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: DNA damage checkpoint signaling, TOR signaling; MF: protein binding, protein phosphatase activator activity, protein phosphatase inhibitor activity; CC: cytoplasm, cytosol
Pathways: Ciliary landscape
UniProt: O75663
Entrez ID: 261726
|
Does Knockout of FAM50A in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
FAM50A
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: FAM50A (family with sequence similarity 50 member A)
Type: protein-coding
Summary: This gene belongs to the FAM50 family. The encoded protein is highly conserved in length and sequence across different species. It is a basic protein containing a nuclear localization signal, and may function as a DNA-binding protein or a transcriptional factor. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: RNA splicing, chromatin organization, mRNA processing, regulation of RNA splicing, spermatogenesis; MF: RNA binding, protein binding; CC: nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q14320
Entrez ID: 9130
|
Does Knockout of CLN5 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
CLN5
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CLN5 (CLN5 lysosomal BMP synthase)
Type: protein-coding
Summary: This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.[provided by RefSeq, Oct 2008].
Gene Ontology: BP: brain development, glycosylation, lysosomal lumen acidification, lysosome organization, neurogenesis, neuron maturation, positive regulation of GTP binding, protein catabolic process, retrograde transport, endosome to Golgi, signal peptide processing, visual perception; MF: D-mannose binding, bis(monoacylglycero)phosphate synthase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, long-chain fatty acyl-CoA hydrolase activity, protein binding, transferase activity; CC: Golgi apparatus, cytosol, endoplasmic reticulum, extracellular exosome, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm, vacuolar lumen
Pathways: Lysosome - Homo sapiens (human)
UniProt: O75503
Entrez ID: 1203
|
Does Knockout of KDELR3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
KDELR3
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: KDELR3 (KDEL endoplasmic reticulum protein retention receptor 3)
Type: protein-coding
Summary: This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: protein retention in ER lumen, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: ER retention sequence binding, KDEL sequence binding, protein binding; CC: COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cis-Golgi network, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, IRE1alpha activates chaperones, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Unfolded Protein Response (UPR), Vesicle-mediated transport, Vibrio cholerae infection - Homo sapiens (human), XBP1(S) activates chaperone genes, adp-ribosylation factor
UniProt: O43731
Entrez ID: 11015
|
Does Knockout of INHBC in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
INHBC
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: INHBC (inhibin subunit beta C)
Type: protein-coding
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016].
Gene Ontology: MF: cytokine activity, growth factor activity, hormone activity, transforming growth factor beta receptor binding; CC: extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human), Glycoprotein hormones, Metabolism of proteins, Peptide hormone biosynthesis, Peptide hormone metabolism, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), TGF-beta signaling pathway - Homo sapiens (human)
UniProt: P55103
Entrez ID: 3626
|
Does Knockout of CDC14B in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
CDC14B
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: CDC14B (cell division cycle 14B)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, cilium assembly, microtubule cytoskeleton organization, mitotic G2 DNA damage checkpoint signaling, positive regulation of cytokinesis, positive regulation of ubiquitin protein ligase activity, protein dephosphorylation, regulation of exit from mitosis; MF: hydrolase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity; CC: cell junction, cytoplasm, cytosol, mitotic spindle, nucleolus, nucleoplasm, nucleus, spindle pole
Pathways: Cell cycle, Cell cycle - Homo sapiens (human), MAPK family signaling cascades, MAPK6/MAPK4 signaling, PLK1 signaling events, Signal Transduction
UniProt: O60729
Entrez ID: 8555
|
Does Knockout of MS4A6A in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
MS4A6A
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: MS4A6A (membrane spanning 4-domains A6A)
Type: protein-coding
Summary: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011].
Gene Ontology: CC: membrane, plasma membrane, trans-Golgi network
Pathways:
UniProt: Q9H2W1
Entrez ID: 64231
|
Does Knockout of TRAPPC1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
TRAPPC1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: TRAPPC1 (trafficking protein particle complex subunit 1)
Type: protein-coding
Summary: This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, azurophil granule lumen, cytoplasm, cytosol, endoplasmic reticulum, extracellular region
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9Y5R8
Entrez ID: 58485
|
Does Knockout of CINP in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
CINP
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CINP (cyclin dependent kinase 2 interacting protein)
Type: protein-coding
Summary: The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, cell division, ribosomal large subunit biogenesis, ribosome biogenesis; MF: preribosome binding, protein binding
Pathways:
UniProt: Q9BW66
Entrez ID: 51550
|
Does Knockout of ENTPD4 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
ENTPD4
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)
Type: protein-coding
Summary: This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: CTP metabolic process, GDP catabolic process, UDP catabolic process, nucleobase-containing small molecule catabolic process, purine ribonucleotide metabolic process, pyrimidine ribonucleotide catabolic process; MF: CDP phosphatase activity, CTPase activity, GDP phosphatase activity, GTPase activity, UDP phosphatase activity, hydrolase activity, nucleoside diphosphate phosphatase activity, protein binding, ribonucleoside triphosphate phosphatase activity; CC: Golgi apparatus, Golgi membrane, autophagosome membrane, cytoplasmic vesicle, lysosomal membrane, lysosome, membrane
Pathways: Lysosome - Homo sapiens (human), Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Phosphate bond hydrolysis by NTPDase proteins, Purine metabolism - Homo sapiens (human), Pyrimidine metabolism - Homo sapiens (human)
UniProt: Q9Y227
Entrez ID: 9583
|
Does Knockout of ABCB7 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
ABCB7
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ABCB7 (ATP binding cassette subfamily B member 7)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: heme transport, intracellular iron ion homeostasis, iron ion transmembrane transport, iron-sulfur cluster assembly, iron-sulfur cluster export from the mitochondrion, negative regulation of reactive oxygen species biosynthetic process, positive regulation of heme biosynthetic process, positive regulation of iron-sulfur cluster assembly, transmembrane transport; MF: ABC-type iron-sulfur cluster transporter activity, ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, heme transmembrane transporter activity, identical protein binding, nucleotide binding, protein binding, protein homodimerization activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: ABC transporters - Homo sapiens (human), ABC-family proteins mediated transport, Cytosolic iron-sulfur cluster assembly, Metabolism, Mitochondrial ABC transporters, Transport of small molecules
UniProt: O75027
Entrez ID: 22
|
Does Knockout of GOLGA6A in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
GOLGA6A
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: GOLGA6A (golgin A6 family member A)
Type: protein-coding
Summary: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The protein encoded by this gene is a member of the golgin family of proteins, whose members localize to the Golgi. This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, that are greather than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosome rearrangements that underlie genomic disease. The protein encoded by this gene is thought to be a functional golgin protein while the majority of the related copies of this gene are thought to be transcribed pseudogenes. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: Golgi apparatus, Golgi cis cisterna, Golgi cisterna membrane, cis-Golgi network
Pathways:
UniProt: Q9NYA3
Entrez ID: 342096
|
Does Knockout of ALG6 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
ALG6
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: ALG6 (ALG6 alpha-1,3-glucosyltransferase)
Type: protein-coding
Summary: This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein glycosylation; MF: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity, dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity, glucosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, protein binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, lumenal side of endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective ALG6 causes CDG-1c, Disease, Diseases associated with N-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, GPCRs, Other, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), Post-translational protein modification, dolichyl-diphosphooligosaccharide biosynthesis
UniProt: Q9Y672
Entrez ID: 29929
|
Does Knockout of RAP2B in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
RAP2B
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: RAP2B (RAP2B, member of RAS oncogene family)
Type: protein-coding
Summary: This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Rap protein signal transduction, establishment of endothelial intestinal barrier, negative regulation of cell migration, platelet activation, platelet aggregation, regulation of protein tyrosine kinase activity, signal transduction; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding, protein domain specific binding; CC: bicellular tight junction, bounding membrane of organelle, cell-cell contact zone, cytoplasmic vesicle membrane, cytosol, endomembrane system, endosome, extracellular exosome, membrane, membrane raft, plasma membrane, recycling endosome, recycling endosome membrane, specific granule membrane, tertiary granule membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, phospholipase c-epsilon pathway
UniProt: P61225
Entrez ID: 5912
|
Does Knockout of UBE2E1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
UBE2E1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: UBE2E1 (ubiquitin conjugating enzyme E2 E1)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: ISG15-protein conjugation, negative regulation of gene expression, positive regulation of transcription by RNA polymerase II, protein K48-linked ubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, ISG15 transferase activity, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity; CC: cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Antiviral mechanism by IFN-stimulated genes, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, E3 ubiquitin ligases ubiquitinate target proteins, Gene expression (Transcription), Generic Transcription Pathway, ISG15 antiviral mechanism, Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Interferon Signaling, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Phosphorylation of the APC/C, Photodynamic therapy-induced unfolded protein response, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: P51965
Entrez ID: 7324
|
Does Knockout of PPCS in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
PPCS
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: PPCS (phosphopantothenoylcysteine synthetase)
Type: protein-coding
Summary: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: acetyl-CoA biosynthetic process, coenzyme A biosynthetic process, heart process; MF: ATP binding, identical protein binding, ligase activity, nucleotide binding, phosphopantothenate--cysteine ligase activity, protein homodimerization activity; CC: cytoplasm, cytosol, nucleus
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA Biosynthesis, Pantothenate and CoA biosynthesis - Homo sapiens (human), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q9HAB8
Entrez ID: 79717
|
Does Knockout of RAD51D in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
RAD51D
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: RAD51D (RAD51 paralog D)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA strand invasion, chromosome organization, double-strand break repair via homologous recombination, interstrand cross-link repair, reciprocal meiotic recombination, regulation of cell cycle, telomere maintenance, telomere maintenance via recombination; MF: ATP binding, ATP-dependent DNA damage sensor activity, ATP-dependent activity, acting on DNA, DNA binding, four-way junction DNA binding, gamma-tubulin binding, nucleotide binding, protein binding, single-stranded DNA binding; CC: Rad51B-Rad51C-Rad51D-XRCC2 complex, centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytoskeleton, microtubule organizing center, nucleoplasm, nucleus, replication fork
Pathways: DNA Double-Strand Break Repair, DNA Repair, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Defective homologous recombination repair (HRR) due to BRCA1 loss of function, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Defective homologous recombination repair (HRR) due to PALB2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to PALB2, Presynaptic phase of homologous DNA pairing and strand exchange, RNA Polymerase II Transcription, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: O75771
Entrez ID: 5892
|
Does Knockout of SYVN1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
SYVN1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SYVN1 (synoviolin 1)
Type: protein-coding
Summary: This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011].
Gene Ontology: BP: ERAD pathway, endoplasmic reticulum mannose trimming, immature B cell differentiation, negative regulation of T-helper 1 type immune response, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein stabilization, protein ubiquitination, retrograde protein transport, ER to cytosol, ubiquitin-dependent protein catabolic process; MF: ATPase binding, DNA-binding transcription factor binding, metal ion binding, protein binding, protein-folding chaperone binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-specific protease binding, unfolded protein binding, zinc ion binding; CC: Derlin-1 retrotranslocation complex, Hrd1p ubiquitin ligase ERAD-L complex, Hrd1p ubiquitin ligase complex, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, membrane, nucleoplasm, smooth endoplasmic reticulum
Pathways: Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, Cellular responses to stimuli, Cellular responses to stress, Disease, Diseases of signal transduction by growth factor receptors and second messengers, ER Quality Control Compartment (ERQC), Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, IRE1alpha activates chaperones, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Signal Transduction, Signaling by Hedgehog, Ubiquitin mediated proteolysis - Homo sapiens (human), Unfolded Protein Response (UPR), XBP1(S) activates chaperone genes
UniProt: Q86TM6
Entrez ID: 84447
|
Does Knockout of EIF1AD in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
EIF1AD
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: EIF1AD (eukaryotic translation initiation factor 1A domain containing)
Type: protein-coding
Summary: Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protein binding, translation initiation factor activity; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8N9N8
Entrez ID: 84285
|
Does Knockout of TFB1M in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
TFB1M
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: TFB1M (transcription factor B1, mitochondrial)
Type: protein-coding
Summary: The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010].
Gene Ontology: BP: methylation, rRNA methylation, rRNA modification, rRNA processing, transcription initiation at mitochondrial promoter; MF: DNA binding, RNA binding, S-adenosyl-L-methionine binding, methyltransferase activity, mitochondrial transcription factor activity, protein binding, rRNA (adenine-N6,N6-)-dimethyltransferase activity, transferase activity; CC: mitochondrial matrix, mitochondrial nucleoid, mitochondrion
Pathways: Energy Metabolism, Metabolism of RNA, Mitochondrial Gene Expression, Mitochondrial biogenesis, Organelle biogenesis and maintenance, Transcriptional activation of mitochondrial biogenesis, rRNA modification in the mitochondrion, rRNA processing, rRNA processing in the mitochondrion
UniProt: Q8WVM0
Entrez ID: 51106
|
Does Knockout of LCE2D in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
LCE2D
|
cell proliferation
|
Cancer Cell Line
|
Gene: LCE2D (late cornified envelope 2D)
Type: protein-coding
Summary: Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epidermis development, keratinization
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q5TA82
Entrez ID: 353141
|
Does Knockout of MRFAP1L1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
MRFAP1L1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: MRFAP1L1 (Morf4 family associated protein 1 like 1)
Type: protein-coding
Summary: Enables identical protein binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: identical protein binding, protein binding
Pathways:
UniProt: Q96HT8
Entrez ID: 114932
|
Does Knockout of SLC37A3 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
SLC37A3
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: SLC37A3 (solute carrier family 37 member 3)
Type: protein-coding
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in carbohydrate transport and transmembrane transport. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: glucose-6-phosphate transport, phosphate ion transmembrane transport, transmembrane transport, xenobiotic transmembrane transport; MF: glucose 6-phosphate:phosphate antiporter activity, protein binding, transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, lysosomal membrane, lysosome, membrane
Pathways:
UniProt: Q8NCC5
Entrez ID: 84255
|
Does Knockout of POFUT1 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 1
| 1,480
|
Knockout
|
POFUT1
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: POFUT1 (protein O-fucosyltransferase 1)
Type: protein-coding
Summary: This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Notch signaling pathway, angiogenesis, fucose metabolic process, heart development, nervous system development, protein O-linked glycosylation via fucose, protein glycosylation, regulation of Notch signaling pathway, somitogenesis; MF: glycosyltransferase activity, peptide-O-fucosyltransferase activity, transferase activity; CC: endoplasmic reticulum, membrane
Pathways: Notch, Other types of O-glycan biosynthesis - Homo sapiens (human), Pre-NOTCH Expression and Processing, Pre-NOTCH Processing in the Endoplasmic Reticulum, Signal Transduction, Signaling by NOTCH
UniProt: Q9H488
Entrez ID: 23509
|
Does Knockout of LRGUK in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
LRGUK
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: LRGUK (leucine rich repeats and guanylate kinase domain containing)
Type: protein-coding
Summary: Predicted to enable guanylate kinase activity. Predicted to be involved in axoneme assembly and spermatogenesis. Predicted to be located in acrosomal vesicle and manchette. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: GDP metabolic process, GMP metabolic process, axoneme assembly, cell differentiation, spermatogenesis; MF: ATP binding, GMP kinase activity, kinase activity, nucleotide binding, protein binding, transferase activity; CC: acrosomal vesicle, cell projection, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, manchette
Pathways:
UniProt: Q96M69
Entrez ID: 136332
|
Does Knockout of SULF1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
SULF1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: SULF1 (sulfatase 1)
Type: protein-coding
Summary: This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: apoptotic process, bone development, cartilage development, chondrocyte development, embryonic skeletal system development, esophagus smooth muscle contraction, glial cell-derived neurotrophic factor receptor signaling pathway, glomerular basement membrane development, glomerular filtration, heparan sulfate proteoglycan metabolic process, innervation, kidney development, negative regulation of angiogenesis, negative regulation of cell migration, negative regulation of endothelial cell proliferation, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of prostatic bud formation, positive regulation of BMP signaling pathway, positive regulation of Wnt signaling pathway, positive regulation of vascular endothelial growth factor production, regulation of fibroblast growth factor receptor signaling pathway, vascular endothelial growth factor receptor signaling pathway; MF: N-acetylglucosamine-6-sulfatase activity, arylsulfatase activity, calcium ion binding, glycosaminoglycan binding, hydrolase activity, metal ion binding, sulfuric ester hydrolase activity; CC: Golgi apparatus, Golgi stack, cell surface, endoplasmic reticulum, extracellular matrix, extracellular region, extracellular space, membrane raft, plasma membrane
Pathways:
UniProt: Q8IWU6
Entrez ID: 23213
|
Does Knockout of PSMB7 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
PSMB7
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PSMB7 (proteasome 20S subunit beta 7)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: endopeptidase activity, hydrolase activity, peptidase activity, protein binding, threonine-type endopeptidase activity; CC: cilium, cytoplasm, cytosol, extracellular region, ficolin-1-rich granule lumen, nuclear body, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: Q99436
Entrez ID: 5695
|
Does Knockout of FOXA1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
FOXA1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: FOXA1 (forkhead box A1)
Type: protein-coding
Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Notch signaling pathway, alveolar secondary septum development, anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, cell differentiation, chromatin organization, chromatin remodeling, connective tissue development, dopaminergic neuron differentiation, dorsal/ventral neural tube patterning, epithelial cell maturation involved in prostate gland development, epithelial tube branching involved in lung morphogenesis, glucose homeostasis, hormone metabolic process, lung development, lung epithelial cell differentiation, lung morphogenesis, mesenchymal-epithelial cell signaling involved in prostate gland development, negative regulation of epithelial to mesenchymal transition, negative regulation of transcription by RNA polymerase II, neuron differentiation, neuron fate specification, positive regulation of DNA-binding transcription factor activity, positive regulation of apoptotic process, positive regulation of cell-cell adhesion mediated by cadherin, positive regulation of dopaminergic neuron differentiation, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of miRNA transcription, positive regulation of mitotic cell cycle, positive regulation of smoothened signaling pathway, positive regulation of transcription by RNA polymerase II, prostate gland epithelium morphogenesis, prostate gland stromal morphogenesis, regulation of DNA-templated transcription, regulation of cell cycle, regulation of gene expression, regulation of transcription by RNA polymerase II, respiratory basal cell differentiation, response to estradiol, secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development, smoothened signaling pathway, tube morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, protein binding, protein domain specific binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, fibrillar center, microvillus, nucleoplasm, nucleus
Pathways: AndrogenReceptor, Developmental Biology, Direct p53 effectors, ESR-mediated signaling, Endoderm differentiation, Estrogen-dependent gene expression, FOXA1 transcription factor network, FOXA2 and FOXA3 transcription factor networks, FOXA2 pathway, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Formation of axial mesoderm, Gastrulation, Mesodermal commitment pathway, Signal Transduction, Signaling by Nuclear Receptors
UniProt: P55317
Entrez ID: 3169
|
Does Knockout of BYSL in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
BYSL
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: BYSL (bystin like)
Type: protein-coding
Summary: Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: blastocyst formation, in utero embryonic development, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, regulation of protein localization to nucleolus, ribosome biogenesis, stem cell proliferation, trophectodermal cell differentiation; MF: RNA binding, protein binding, snoRNA binding; CC: apical part of cell, chromosome, cytoplasm, cytosol, membrane, nucleolus, nucleoplasm, nucleus, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q13895
Entrez ID: 705
|
Does Knockout of PTH in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
PTH
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: PTH (parathyroid hormone)
Type: protein-coding
Summary: This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho protein signal transduction, adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, bone mineralization, bone resorption, cAMP metabolic process, calcium ion homeostasis, cell-cell signaling, homeostasis of number of cells within a tissue, hormone-mediated apoptotic signaling pathway, intracellular calcium ion homeostasis, macromolecule biosynthetic process, magnesium ion homeostasis, negative regulation of apoptotic process in bone marrow cell, negative regulation of bone mineralization involved in bone maturation, negative regulation of chondrocyte differentiation, negative regulation of gene expression, phosphate ion homeostasis, positive regulation of D-glucose import, positive regulation of bone mineralization, positive regulation of cell proliferation in bone marrow, positive regulation of gene expression, positive regulation of glycogen biosynthetic process, positive regulation of inositol phosphate biosynthetic process, positive regulation of ossification, positive regulation of osteoclast proliferation, positive regulation of signal transduction, positive regulation of transcription by RNA polymerase II, regulation of gene expression, response to cadmium ion, response to ethanol, response to fibroblast growth factor, response to lead ion, response to nutrient levels, response to parathyroid hormone, response to vitamin D, response to xenobiotic stimulus, signal transduction, skeletal system development, transcription by RNA polymerase II; MF: hormone activity, parathyroid hormone receptor binding, peptide hormone receptor binding, protein binding, receptor ligand activity, type 1 parathyroid hormone receptor binding; CC: extracellular region, extracellular space
Pathways: Class B/2 (Secretin family receptors), Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), FGF23 signaling in hypophosphatemic rickets and related disorders, G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Homo sapiens (human), Osteoblast Signaling, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Regucalcin in proximal tubule epithelial kidney cells, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Vitamin D Metabolism, Vitamin D Receptor Pathway
UniProt: P01270
Entrez ID: 5741
|
Does Knockout of GRAPL in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
GRAPL
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GRAPL (GRB2 related adaptor protein like)
Type: protein-coding
Summary: Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in cell migration and signal transduction. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell migration, enzyme-linked receptor protein signaling pathway; MF: protein binding, receptor tyrosine kinase binding, signaling adaptor activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q8TC17
Entrez ID: 400581
|
Does Knockout of STON1 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
STON1
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: STON1 (stonin 1)
Type: protein-coding
Summary: Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010].
Gene Ontology: BP: clathrin-dependent endocytosis, endocytosis, focal adhesion assembly, focal adhesion disassembly, platelet-derived growth factor receptor signaling pathway, regulation of endocytosis, ruffle assembly, substrate-dependent cell migration, synaptic vesicle endocytosis; MF: cargo adaptor activity, clathrin adaptor activity; CC: AP-2 adaptor complex, cell leading edge, cell projection, clathrin-coated pit, cytoplasm, membrane, synaptic vesicle
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9Y6Q2
Entrez ID: 11037
|
Does Knockout of NEUROG3 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
NEUROG3
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: NEUROG3 (neurogenin 3)
Type: protein-coding
Summary: The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010].
Gene Ontology: BP: axon development, cell differentiation, central nervous system development, enteroendocrine cell differentiation, epithelial cell differentiation, forebrain development, hindbrain development, negative regulation of transcription by RNA polymerase II, nervous system development, peripheral nervous system development, positive regulation of DNA-templated transcription, positive regulation of cell differentiation, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of dendrite morphogenesis, sensory organ development, spinal cord development, transdifferentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, double-stranded DNA binding, protein binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways: Developmental Biology, Maturity onset diabetes of the young - Homo sapiens (human), Notch-mediated HES/HEY network, Regulation of beta-cell development, Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
UniProt: Q9Y4Z2
Entrez ID: 50674
|
Does Knockout of TMEM229B in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
TMEM229B
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TMEM229B (transmembrane protein 229B)
Type: protein-coding
Summary: Predicted to act upstream of or within response to bacterium. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: macrophage activation, response to bacterium
Pathways:
UniProt: Q8NBD8
Entrez ID: 161145
|
Does Knockout of MED8 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
MED8
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: MED8 (mediator complex subunit 8)
Type: protein-coding
Summary: This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q96G25
Entrez ID: 112950
|
Does Knockout of TCOF1 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
TCOF1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: TCOF1 (treacle ribosome biogenesis factor 1)
Type: protein-coding
Summary: This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
Gene Ontology: BP: neural crest cell development, neural crest formation, nucleolar large rRNA transcription by RNA polymerase I, regulation of translation, skeletal system development; MF: RNA binding, protein binding, protein heterodimerization activity, protein-macromolecule adaptor activity, scaffold protein binding; CC: cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q13428
Entrez ID: 6949
|
Does Knockout of MFSD11 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
MFSD11
|
response to virus
|
Huh-7 Cell
|
Gene: MFSD11 (major facilitator superfamily domain containing 11)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: response to food, response to starvation
Pathways:
UniProt: O43934
Entrez ID: 79157
|
Does Knockout of HMOX1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
HMOX1
|
response to virus
|
Hepatoma Cell Line
|
Gene: HMOX1 (heme oxygenase 1)
Type: protein-coding
Summary: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: angiogenesis, apoptotic process, cellular response to arsenic-containing substance, cellular response to cadmium ion, cellular response to cisplatin, cellular response to heat, endothelial cell proliferation, epithelial cell apoptotic process, erythrocyte homeostasis, heme catabolic process, heme metabolic process, heme oxidation, intracellular iron ion homeostasis, intracellular signal transduction, low-density lipoprotein particle clearance, macroautophagy, multicellular organismal-level iron ion homeostasis, negative regulation of cytokine production involved in inflammatory response, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of ferroptosis, negative regulation of leukocyte migration, negative regulation of macroautophagy, negative regulation of smooth muscle cell proliferation, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of chemokine production, positive regulation of epithelial cell apoptotic process, positive regulation of macroautophagy, positive regulation of smooth muscle cell proliferation, regulation of angiogenesis, regulation of transcription by RNA polymerase II, response to hydrogen peroxide, response to nicotine, response to oxidative stress, smooth muscle hyperplasia, wound healing involved in inflammatory response; MF: enzyme binding, heme binding, heme oxygenase (decyclizing) activity, identical protein binding, metal ion binding, oxidoreductase activity, protein binding, protein homodimerization activity, structural molecule activity; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular space, membrane, mitochondrial outer membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Acute Intermittent Porphyria, CAMKK2 Pathway, Cell recruitment (pro-inflammatory response), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Congenital Erythropoietic Porphyria (CEP) or Gunther Disease, Cytokine Signaling in Immune system, Cytoprotection by HMOX1, Disease, Ferroptosis, Ferroptosis - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), HIF-1 signaling pathway - Homo sapiens (human), HIF-1-alpha transcription factor network, Heme degradation, Heme signaling, Hepatocellular carcinoma - Homo sapiens (human), Hereditary Coproporphyria (HCP), IL-10 Anti-inflammatory Signaling Pathway, IL-18 signaling pathway, Immune System, Infectious disease, Inflammasomes, Innate Immune System, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, Interleukin-4 and Interleukin-13 signaling, Iron uptake and transport, KEAP1-NFE2L2 pathway, Leishmania infection, Lung fibrosis, Metabolism, Metabolism of porphyrins, MicroRNAs in cancer - Homo sapiens (human), Mineral absorption - Homo sapiens (human), NFE2L2 regulating anti-oxidant/detoxification enzymes, NRF2 pathway, NRF2-ARE regulation, Nuclear Receptors Meta-Pathway, Nuclear events mediated by NFE2L2, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Overview of nanoparticle effects, Oxidative Stress, Parasitic Infection Pathways, Pathways in cancer - Homo sapiens (human), Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, Phytochemical activity on NRF2 transcriptional activation, Porphyria Variegata (PV), Porphyrin Metabolism, Porphyrin and chlorophyll metabolism - Homo sapiens (human), Protein localization, Purinergic signaling in leishmaniasis infection, Regulation of HMOX1 expression and activity, Signaling by Interleukins, The NLRP3 inflammasome, Transport of small molecules, Validated transcriptional targets of AP1 family members Fra1 and Fra2, heme degradation, il-10 anti-inflammatory signaling pathway, oxidative stress induced gene expression via nrf2
UniProt: P09601
Entrez ID: 3162
|
Does Knockout of LSM7 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
LSM7
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: LSM7 (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process; MF: RNA binding, U6 snRNA binding, protein binding; CC: Lsm1-7-Pat1 complex, Lsm2-8 complex, U12-type spliceosomal complex, U2-type precatalytic spliceosome, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, catalytic step 2 spliceosome, cytosol, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Homo sapiens (human), Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q9UK45
Entrez ID: 51690
|
Does Knockout of TET1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
TET1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: TET1 (tet methylcytosine dioxygenase 1)
Type: protein-coding
Summary: DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cellular response to reactive oxygen species, chromatin organization, chromatin remodeling, epigenetic regulation of gene expression, inner cell mass cell differentiation, negative regulation of cell migration, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of gene expression via chromosomal CpG island demethylation, positive regulation of macromolecule biosynthetic process, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, protein O-linked glycosylation, regulation of gene expression, stem cell population maintenance; MF: 2-oxoglutarate-dependent dioxygenase activity, DNA 5-methylcytosine dioxygenase activity, DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, dioxygenase activity, iron ion binding, metal ion binding, methyl-CpG binding, oxidoreductase activity, protein binding, zinc ion binding; CC: Sin3-type complex, chromosome, nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), MECP2 and Associated Rett Syndrome, Mesodermal commitment pathway, TET1,2,3 and TDG demethylate DNA, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate
UniProt: Q8NFU7
Entrez ID: 80312
|
Does Knockout of RPIA in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
RPIA
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RPIA (ribose 5-phosphate isomerase A)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: D-ribose metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch; MF: carbohydrate binding, identical protein binding, isomerase activity, monosaccharide binding, protein binding, ribose-5-phosphate isomerase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Disease, Diseases of carbohydrate metabolism, Diseases of metabolism, Glucose-6-phosphate dehydrogenase deficiency, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose Phosphate Metabolism, Pentose Phosphate Pathway, Pentose phosphate pathway, Pentose phosphate pathway - Homo sapiens (human), Pentose phosphate pathway disease, RPIA deficiency: failed conversion of R5P to RU5P, RPIA deficiency: failed conversion of RU5P to R5P, Ribose-5-phosphate isomerase deficiency, Transaldolase deficiency, Warburg Effect, pentose phosphate pathway, pentose phosphate pathway (non-oxidative branch)
UniProt: P49247
Entrez ID: 22934
|
Does Knockout of UTP18 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
UTP18
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: UTP18 (UTP18 small subunit processome component)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis; MF: RNA binding, protein binding; CC: Pwp2p-containing subcomplex of 90S preribosome, nuclear membrane, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y5J1
Entrez ID: 51096
|
Does Knockout of ZBTB20 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
ZBTB20
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ZBTB20 (zinc finger and BTB domain containing 20)
Type: protein-coding
Summary: This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017].
Gene Ontology: BP: cellular response to glucose stimulus, lipid homeostasis, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, positive regulation of glycolytic process, positive regulation of interferon-beta production, positive regulation of interleukin-6 production, positive regulation of lipid biosynthetic process, positive regulation of tumor necrosis factor production, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: cytoplasm, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q9HC78
Entrez ID: 26137
|
Does Knockout of UTP3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
UTP3
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: UTP3 (UTP3 small subunit processome component)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in brain development and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: brain development, chromatin organization, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit biogenesis; MF: RNA binding, protein binding; CC: nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NQZ2
Entrez ID: 57050
|
Does Knockout of PRTG in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
PRTG
|
response to chemicals
|
Melanoma Cell Line
|
Gene: PRTG (protogenin)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014].
Gene Ontology: BP: cell-cell adhesion, negative regulation of neurogenesis; MF: identical protein binding, signaling receptor activity; CC: extracellular space, membrane, plasma membrane
Pathways: Neural Crest Differentiation
UniProt: Q2VWP7
Entrez ID: 283659
|
Does Knockout of MT2A in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
MT2A
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: MT2A (metallothionein 2A)
Type: protein-coding
Summary: This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. [provided by RefSeq, Sep 2017].
Gene Ontology: BP: cellular response to cadmium ion, cellular response to copper ion, cellular response to erythropoietin, cellular response to interleukin-3, cellular response to zinc ion, detoxification of copper ion, intracellular copper ion homeostasis, intracellular zinc ion homeostasis, negative regulation of growth; MF: metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol, nucleus
Pathways: AP-1 transcription factor network, Cellular responses to stimuli, Copper homeostasis, Cytokine Signaling in Immune system, Immune System, Interferon Signaling, Interferon gamma signaling, Lung fibrosis, Metallothioneins bind metals, Mineral absorption - Homo sapiens (human), Response to metal ions, Zinc homeostasis
UniProt: P02795
Entrez ID: 4502
|
Does Knockout of ARR3 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
ARR3
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: ARR3 (arrestin 3)
Type: protein-coding
Summary: The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016].
Gene Ontology: BP: G protein-coupled receptor internalization, endocytosis, signal transduction, visual perception; MF: G protein-coupled receptor binding, opsin binding, phosphoprotein binding, protein binding; CC: cell projection, cytoplasm, photoreceptor inner segment, photoreceptor outer segment, synapse
Pathways: CXCR4-mediated signaling events, Joubert Syndrome, Thromboxane A2 receptor signaling, Visual signal transduction: Cones
UniProt: P36575
Entrez ID: 407
|
Does Knockout of UNC13A in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
UNC13A
|
response to chemicals
|
Melanoma Cell Line
|
Gene: UNC13A (unc-13 homolog A)
Type: protein-coding
Summary: This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: cell differentiation, chemical synaptic transmission, dense core granule priming, exocytosis, neuronal dense core vesicle exocytosis, neurotransmitter secretion, positive regulation of dendrite extension, regulation of synaptic transmission, glutamatergic, synaptic transmission, glutamatergic, synaptic vesicle docking, synaptic vesicle priming; MF: calcium ion binding, calmodulin binding, diacylglycerol binding, metal ion binding, phospholipid binding, syntaxin-1 binding, zinc ion binding; CC: cell projection, cytoplasm, membrane, neuromuscular junction, neuron projection, plasma membrane, presynaptic active zone, presynaptic membrane, synapse, synaptic vesicle membrane, terminal bouton
Pathways: 16p11.2 proximal deletion syndrome, Synaptic Vesicle Pathway, Synaptic vesicle cycle - Homo sapiens (human)
UniProt: Q9UPW8
Entrez ID: 23025
|
Does Knockout of TEX10 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
TEX10
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: TEX10 (testis expressed 10)
Type: protein-coding
Summary: Located in mitochondrion and nucleoplasm. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: MLL1 complex, cytoplasm, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NXF1
Entrez ID: 54881
|
Does Knockout of STRAP in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
STRAP
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: STRAP (serine/threonine kinase receptor associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of transforming growth factor beta receptor signaling pathway; and spliceosomal snRNP assembly. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, maintenance of gastrointestinal epithelium, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, neuron differentiation, protein-RNA complex assembly, spliceosomal snRNP assembly; MF: RNA binding, U2 snRNP binding, mRNA binding, protein binding, signaling receptor binding; CC: SMN complex, SMN-Sm protein complex, cytoplasm, cytosol, nucleus
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Downregulation of TGF-beta receptor signaling, Epithelial to mesenchymal transition in colorectal cancer, Positive Regulation of CDH1 Gene Transcription, RNA transport - Homo sapiens (human), Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta Signaling Pathway, TGF-beta receptor signaling, TGF-beta receptor signaling activates SMADs, TGF_beta_Receptor
UniProt: Q9Y3F4
Entrez ID: 11171
|
Does Knockout of RCC1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
RCC1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: RCC1 (regulator of chromosome condensation 1)
Type: protein-coding
Summary: Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in several processes, including G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Located in chromatin; cytoplasm; and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, chromosome segregation, mitotic nuclear membrane reassembly, mitotic spindle organization, regulation of mitotic cell cycle, regulation of mitotic nuclear division, regulation of mitotic spindle assembly, spindle assembly, viral process; MF: DNA binding, chromatin binding, guanyl-nucleotide exchange factor activity, histone binding, nucleosomal DNA binding, nucleosome binding, protein binding, protein heterodimerization activity, small GTPase binding, sulfate binding; CC: chromatin, chromosome, condensed nuclear chromosome, cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways: 22q11.2 copy number variation syndrome, Cell Cycle, Cell Cycle, Mitotic, Disease, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, Infectious disease, Interactions of Rev with host cellular proteins, Late Phase of HIV Life Cycle, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Nuclear Envelope (NE) Reassembly, Nuclear import of Rev protein, Postmitotic nuclear pore complex (NPC) reformation, Rev-mediated nuclear export of HIV RNA, Validated targets of C-MYC transcriptional activation, Viral Infection Pathways, cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, role of ran in mitotic spindle regulation
UniProt: P18754
Entrez ID: 1104
|
Does Knockout of CAPN10 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
CAPN10
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CAPN10 (calpain 10)
Type: protein-coding
Summary: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: cellular component disassembly involved in execution phase of apoptosis, cellular response to insulin stimulus, positive regulation of D-glucose import, positive regulation of insulin secretion, positive regulation of intracellular transport, positive regulation of type B pancreatic cell apoptotic process, proteolysis, regulation of actin cytoskeleton organization, type B pancreatic cell apoptotic process, vesicle-mediated transport to the plasma membrane; MF: SNARE binding, calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity, cytoskeletal protein binding, hydrolase activity, peptidase activity, protein binding; CC: cytoplasm, cytosol, mitochondrion, plasma membrane
Pathways: Degradation of the extracellular matrix, Extracellular matrix organization, Integrin-mediated Cell Adhesion
UniProt: Q9HC96
Entrez ID: 11132
|
Does Knockout of SERPINH1 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
SERPINH1
|
response to chemicals
|
Melanoma Cell Line
|
Gene: SERPINH1 (serpin family H member 1)
Type: protein-coding
Summary: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011].
Gene Ontology: BP: chondrocyte development involved in endochondral bone morphogenesis, collagen biosynthetic process, collagen fibril organization, protein maturation, response to unfolded protein; MF: RNA binding, collagen binding, protein binding, serine-type endopeptidase inhibitor activity, unfolded protein binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum-Golgi intermediate compartment, extracellular matrix, extracellular space, membrane raft
Pathways: 15q13.3 copy number variation syndrome, Collagen biosynthesis and modifying enzymes, Collagen formation, Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, Extracellular matrix organization, Type I collagen synthesis in the context of Osteogenesis imperfecta
UniProt: P50454
Entrez ID: 871
|
Does Knockout of CIAO1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
CIAO1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: CIAO1 (cytosolic iron-sulfur assembly component 1)
Type: protein-coding
Summary: Involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in cytoplasm. Part of CIA complex and MMXD complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromosome segregation, iron-sulfur cluster assembly, protein maturation, regulation of transcription by RNA polymerase II; CC: MMXD complex, cytoplasm, cytosolic [4Fe-4S] assembly targeting complex
Pathways: Cytosolic iron-sulfur cluster assembly, Metabolism
UniProt: O76071
Entrez ID: 9391
|
Does Knockout of MAN1C1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
MAN1C1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MAN1C1 (mannosidase alpha class 1C member 1)
Type: protein-coding
Summary: Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERAD pathway, Golgi apparatus mannose trimming, N-glycan processing, carbohydrate metabolic process, protein N-linked glycosylation, protein glycosylation; MF: calcium ion binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity, metal ion binding, protein binding; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, extracellular exosome, membrane
Pathways: Asparagine N-linked glycosylation, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), N-glycan trimming and elongation in the cis-Golgi, Post-translational protein modification, Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2, Protein processing in endoplasmic reticulum - Homo sapiens (human), Transport to the Golgi and subsequent modification, Various types of N-glycan biosynthesis - Homo sapiens (human), Vesicle-mediated transport, er associated degradation (erad) pathway
UniProt: Q9NR34
Entrez ID: 57134
|
Does Knockout of NCOA7 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
NCOA7
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: NCOA7 (nuclear receptor coactivator 7)
Type: protein-coding
Summary: Enables nuclear receptor binding activity and nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of cellular response to oxidative stress, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, response to oxidative stress; MF: nuclear receptor binding, protein binding, transcription coactivator activity; CC: nucleus
Pathways: Aryl Hydrocarbon Receptor Netpath, Validated nuclear estrogen receptor alpha network
UniProt: Q8NI08
Entrez ID: 135112
|
Does Knockout of DEUP1 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
DEUP1
|
response to virus
|
Huh-7 Cell
|
Gene: DEUP1 (deuterosome assembly protein 1)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Predicted to be located in cytoplasm. Predicted to be integral component of membrane. Predicted to be active in centriole and deuterosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell projection organization, centriole replication, de novo centriole assembly involved in multi-ciliated epithelial cell differentiation, multi-ciliated epithelial cell differentiation; MF: identical protein binding, protein binding; CC: centriole, cytoplasm, deuterosome
Pathways:
UniProt: Q05D60
Entrez ID: 159989
|
Does Knockout of ANKRD50 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
ANKRD50
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: ANKRD50 (ankyrin repeat domain containing 50)
Type: protein-coding
Summary: Involved in endocytic recycling. Predicted to be located in endosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endocytic recycling, protein transport
Pathways:
UniProt: Q9ULJ7
Entrez ID: 57182
|
Does Knockout of PRELID3B in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
PRELID3B
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PRELID3B (PRELI domain containing 3B)
Type: protein-coding
Summary: Predicted to enable phosphatidic acid transfer activity. Predicted to be involved in phospholipid transport. Predicted to be active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intermembrane lipid transfer, phospholipid transport; MF: phosphatidic acid transfer activity, protein binding; CC: mitochondrial intermembrane space, mitochondrion
Pathways:
UniProt: Q9Y3B1
Entrez ID: 51012
|
Does Knockout of SRP19 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
SRP19
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SRP19 (signal recognition particle 19)
Type: protein-coding
Summary: Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, cotranslational protein targeting to membrane; MF: 7S RNA binding, RNA binding, protein binding, ribosome binding; CC: cytoplasm, cytosol, nuclear body, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Homo sapiens (human), SRP-dependent cotranslational protein targeting to membrane, Translation
UniProt: P09132
Entrez ID: 6728
|
Does Knockout of TYROBP in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
TYROBP
|
response to virus
|
Hepatoma Cell Line
|
Gene: TYROBP (transmembrane immune signaling adaptor TYROBP)
Type: protein-coding
Summary: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, actin cytoskeleton organization, amyloid-beta clearance, apoptotic cell clearance, cell surface receptor signaling pathway, cellular defense response, cellular response to amyloid-beta, defense response, forebrain development, immune effector process, immune response, immune system process, integrin-mediated signaling pathway, intracellular signal transduction, macrophage activation involved in immune response, microglial cell activation involved in immune response, myeloid leukocyte activation, natural killer cell mediated immunity, negative regulation of B cell proliferation, negative regulation of cytokine production, negative regulation of interleukin-10 production, negative regulation of long-term synaptic potentiation, negative regulation of transforming growth factor beta1 production, negative regulation of type I interferon production, neutrophil activation involved in immune response, osteoclast differentiation, positive regulation of gene expression, positive regulation of immune system process, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, positive regulation of macrophage fusion, positive regulation of microglial cell mediated cytotoxicity, positive regulation of natural killer cell activation, positive regulation of osteoclast development, positive regulation of protein localization to cell surface, positive regulation of receptor localization to synapse, positive regulation of superoxide anion generation, positive regulation of tumor necrosis factor production, positive regulation of type I interferon production, protein stabilization, regulation of biological quality, regulation of osteoclast development, response to axon injury, semaphorin-plexin signaling pathway, signal transduction, stimulatory C-type lectin receptor signaling pathway, stimulatory killer cell immunoglobulin-like receptor signaling pathway; MF: identical protein binding, metal ion binding, molecular adaptor activity, protein binding, protein homodimerization activity, protein-macromolecule adaptor activity, signaling receptor binding; CC: cell surface, membrane, plasma membrane, secretory granule membrane
Pathways: Adaptive Immune System, Axon guidance, Cell-Cell communication, DAP12 interactions, DAP12 signaling, Developmental Biology, Fibrin Complement Receptor 3 Signaling Pathway, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Microglia Pathogen Phagocytosis Pathway, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Nervous system development, Neutrophil degranulation, Osteoclast differentiation - Homo sapiens (human), Other semaphorin interactions, RANKL, Semaphorin interactions, Signal regulatory protein family interactions, TYROBP causal network in microglia
UniProt: O43914
Entrez ID: 7305
|
Does Knockout of USP10 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
USP10
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: USP10 (ubiquitin specific peptidase 10)
Type: protein-coding
Summary: Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, autophagy, cellular response to interleukin-1, chromatin remodeling, monoubiquitinated protein deubiquitination, negative regulation of canonical NF-kappaB signal transduction, negative regulation of stress granule assembly, protein deubiquitination, protein monoubiquitination, proteolysis, regulation of autophagy, regulation of protein stability, rescue of stalled ribosome, ribosome-associated ubiquitin-dependent protein catabolic process, stress granule assembly, translesion synthesis; MF: RNA binding, cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, molecular function inhibitor activity, p53 binding, peptidase activity, protein binding, transmembrane transporter binding; CC: cytoplasm, cytosol, cytosolic ribosome, early endosome, endosome, intermediate filament cytoskeleton, nucleoplasm, nucleus, protein-containing complex
Pathways: DNA Damage Bypass, DNA Repair, Deubiquitination, Metabolism of proteins, Post-translational protein modification, Termination of translesion DNA synthesis, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Ub-specific processing proteases, VEGFA-VEGFR2 Signaling Pathway
UniProt: Q14694
Entrez ID: 9100
|
Does Knockout of TMEM135 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
TMEM135
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: TMEM135 (transmembrane protein 135)
Type: protein-coding
Summary: Predicted to be involved in peroxisome organization. Predicted to act upstream of or within response to cold and response to food. Predicted to be located in mitochondrion and peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: alpha-linolenic acid metabolic process, fatty acid derivative biosynthetic process, fatty acid derivative transport, long-chain fatty acid biosynthetic process, long-chain fatty acid transport, mitochondrion organization, peroxisome organization, regulation of mitochondrial fission, regulation of oxidative phosphorylation, response to cold, response to food, retinal pigment epithelium development, unsaturated fatty acid biosynthetic process; MF: lipid transporter activity, protein binding; CC: lipid droplet, membrane, mitochondrial membrane, mitochondrion, peroxisomal membrane, peroxisome
Pathways:
UniProt: Q86UB9
Entrez ID: 65084
|
Does Knockout of ZNF222 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
ZNF222
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: ZNF222 (zinc finger protein 222)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, metal ion binding, sequence-specific DNA binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9UK12
Entrez ID: 7673
|
Does Knockout of ZNF253 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
ZNF253
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: ZNF253 (zinc finger protein 253)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: O75346
Entrez ID: 56242
|
Does Knockout of MIR1180 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
MIR1180
|
response to virus
|
Hepatoma Cell Line
|
Gene: MIR1180 (microRNA 1180)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100302256
|
Does Knockout of SMARCA2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
SMARCA2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: SMARCA2 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: chromatin remodeling, heterochromatin formation, negative regulation of DNA-templated transcription, negative regulation of cell differentiation, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, spermatid development; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, DNA binding, chromatin binding, helicase activity, histone binding, hydrolase activity, nucleosome array spacer activity, protein binding, transcription cis-regulatory region binding, transcription coactivator activity; CC: GBAF complex, SWI/SNF complex, bBAF complex, brahma complex, chromatin, intermediate filament cytoskeleton, nBAF complex, npBAF complex, nucleoplasm, nucleus
Pathways: C-MYB transcription factor network, E2F transcription factor network, Hepatocellular carcinoma - Homo sapiens (human), Pathways affected in adenoid cystic carcinoma, Regulation of Androgen receptor activity, Retinoblastoma gene in cancer, Rett syndrome causing genes, Thermogenesis, Thermogenesis - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway
UniProt: P51531
Entrez ID: 6595
|
Does Knockout of PPP1R10 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
PPP1R10
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PPP1R10 (protein phosphatase 1 regulatory subunit 10)
Type: protein-coding
Summary: This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: RNA polymerase II promoter clearance, negative regulation of cardiac muscle cell apoptotic process, negative regulation of mitotic DNA damage checkpoint, negative regulation of transcription elongation by RNA polymerase II, positive regulation of telomere maintenance, positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled, positive regulation of transcription elongation by RNA polymerase II, protein import into nucleus, protein stabilization, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: DNA binding, RNA binding, enzyme-substrate adaptor activity, metal ion binding, protein binding, protein phosphatase 1 binding, protein phosphatase inhibitor activity, protein phosphatase regulator activity, zinc ion binding; CC: PTW/PP1 phosphatase complex, chromatin, chromosome, chromosome, telomeric region, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q96QC0
Entrez ID: 5514
|
Does Knockout of MAOA in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
MAOA
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: MAOA (monoamine oxidase A)
Type: protein-coding
Summary: This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: biogenic amine metabolic process, catecholamine metabolic process, dopamine catabolic process, positive regulation of signal transduction; MF: flavin adenine dinucleotide binding, monoamine oxidase activity, oxidoreductase activity, primary methylamine oxidase activity, protein binding; CC: cytosol, membrane, mitochondrial outer membrane, mitochondrion
Pathways: 3-Phosphoglycerate dehydrogenase deficiency, Alcoholism - Homo sapiens (human), Alkaptonuria, Amine Oxidase reactions, Amino Acid metabolism, Amphetamine addiction - Homo sapiens (human), Arginine and proline metabolism - Homo sapiens (human), Biogenic Amine Synthesis, Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB, Biological oxidations, Citalopram Action Pathway, Citalopram Metabolism Pathway, Cocaine addiction - Homo sapiens (human), Cytokine Signaling in Immune system, Defective MAOA causes BRUNS, Dihydropyrimidine Dehydrogenase Deficiency (DHPD), Dimethylglycine Dehydrogenase Deficiency, Disease, Diseases of metabolism, Disulfiram Action Pathway, Dopamine beta-hydroxylase deficiency, Dopamine clearance from the synaptic cleft, Dopamine metabolism, Dopaminergic synapse - Homo sapiens (human), Drug metabolism - cytochrome P450 - Homo sapiens (human), Enzymatic degradation of Dopamine by monoamine oxidase, Enzymatic degradation of dopamine by COMT, Glycine and Serine Metabolism, Glycine, serine and threonine metabolism - Homo sapiens (human), Hawkinsinuria, Histidine Metabolism, Histidine metabolism - Homo sapiens (human), Histidinemia, Hyperglycinemia, non-ketotic, Immune System, Interleukin-4 and Interleukin-13 signaling, Melatonin metabolism and effects, Metabolic disorders of biological oxidation enzymes, Metabolism, Metabolism of serotonin, Monoamine oxidase-a deficiency (MAO-A), Neuronal System, Neurotransmitter Disorders, Neurotransmitter clearance, Neurotransmitter release cycle, Non Ketotic Hyperglycinemia, Norepinephrine Neurotransmitter Release Cycle, Oxidative Stress, Parkinson disease - Homo sapiens (human), Phase I - Functionalization of compounds, Phenylalanine metabolism - Homo sapiens (human), Sarcosinemia, Serotonergic synapse - Homo sapiens (human), Serotonin Transporter Activity, Serotonin clearance from the synaptic cleft, Signaling by Interleukins, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, Transmission across Chemical Synapses, Tryptophan metabolism - Homo sapiens (human), Tyrosine Metabolism, Tyrosine metabolism - Homo sapiens (human), Tyrosinemia Type I, Tyrosinemia, transient, of the newborn, dopamine degradation, melatonin degradation II, noradrenaline and adrenaline degradation, putrescine degradation III, serotonin degradation, superpathway of melatonin degradation, superpathway of tryptophan utilization
UniProt: P21397
Entrez ID: 4128
|
Does Knockout of GTF2E2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
GTF2E2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: GTF2E2 (general transcription factor IIE subunit 2)
Type: protein-coding
Summary: The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA binding, RNA polymerase II general transcription initiation factor activity, TFIIH-class transcription factor complex binding, protein binding; CC: cytosol, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIE complex
Pathways: Basal transcription factors - Homo sapiens (human), Disease, Eukaryotic Transcription Initiation, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Transcription of the HIV genome, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human)
UniProt: P29084
Entrez ID: 2961
|
Does Knockout of ONECUT1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
ONECUT1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ONECUT1 (one cut homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: B cell differentiation, Notch signaling pathway, anatomical structure morphogenesis, cell fate commitment, cell migration, cilium assembly, endocrine pancreas development, endoderm development, enteroendocrine cell differentiation, epithelial cell development, glucose metabolic process, liver development, negative regulation of transforming growth factor beta receptor signaling pathway, pancreas development, pancreatic A cell differentiation, pancreatic D cell differentiation, positive regulation of cell migration, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell-matrix adhesion, regulation of transcription by RNA polymerase II, spleen development, transforming growth factor beta receptor signaling pathway, type B pancreatic cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Multipotent Pancreatic Progenitor Cells, Developmental Lineage of Pancreatic Acinar Cells, Developmental Lineage of Pancreatic Ductal Cells, Endoderm differentiation, FOXM1 transcription factor network, Maturity onset diabetes of the young - Homo sapiens (human), Regulation of beta-cell development, Regulation of gene expression in early pancreatic precursor cells, Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
UniProt: Q9UBC0
Entrez ID: 3175
|
Does Knockout of PPCDC in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
PPCDC
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PPCDC (phosphopantothenoylcysteine decarboxylase)
Type: protein-coding
Summary: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: coenzyme A biosynthetic process; MF: FMN binding, carboxy-lyase activity, catalytic activity, identical protein binding, lyase activity, phosphopantothenoylcysteine decarboxylase activity, protein binding; CC: cytosol, phosphopantothenoylcysteine decarboxylase complex
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA Biosynthesis, Pantothenate and CoA biosynthesis - Homo sapiens (human), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q96CD2
Entrez ID: 60490
|
Does Knockout of MRO in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
MRO
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MRO (maestro)
Type: protein-coding
Summary: This gene is specifically transcribed in males before and after differentiation of testis, and the encoded protein may play an important role in a mammalian sex determination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: nucleolus, nucleus
Pathways:
UniProt: Q9BYG7
Entrez ID: 83876
|
Does Knockout of ELP2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
ELP2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: ELP2 (elongator acetyltransferase complex subunit 2)
Type: protein-coding
Summary: The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016].
Gene Ontology: BP: regulation of receptor signaling pathway via JAK-STAT, regulation of transcription by RNA polymerase II, regulation of translation, tRNA processing, tRNA wobble uridine modification, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, protein kinase binding; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q6IA86
Entrez ID: 55250
|
Does Knockout of COQ4 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
COQ4
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: COQ4 (coenzyme Q4)
Type: protein-coding
Summary: This gene encodes a component of the coenzyme Q biosynthesis pathway. Coenzyme Q, an essential component of the electron transport chain, shuttles electrons between complexes I or II to complex III of the mitochondrial transport chain. This protein appears to play a structural role in stabilizing a complex that contains most of the coenzyme Q biosynthesis enzymes. Mutations in this gene are associated with mitochondrial disorders linked to coenzyme Q deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: ubiquinone biosynthetic process; MF: 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity, lyase activity, protein binding; CC: extrinsic component of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion, protein-containing complex, ubiquinone biosynthesis complex
Pathways: Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Ubiquinol biosynthesis
UniProt: Q9Y3A0
Entrez ID: 51117
|
Does Knockout of SNAPC2 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
SNAPC2
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: SNAPC2 (small nuclear RNA activating complex polypeptide 2)
Type: protein-coding
Summary: This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009].
Gene Ontology: BP: snRNA transcription, transcription by RNA polymerase II, transcription by RNA polymerase III; MF: RNA polymerase II general transcription initiation factor activity; CC: cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes
UniProt: Q13487
Entrez ID: 6618
|
Does Knockout of MORC1 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
MORC1
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: MORC1 (MORC family CW-type zinc finger 1)
Type: protein-coding
Summary: This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009].
Gene Ontology: BP: behavioral fear response, cell differentiation, epigenetic programing of male pronucleus, epigenetic regulation of gene expression, negative regulation of DNA-templated transcription initiation, negative regulation of gene expression, regulatory ncRNA-mediated gene silencing, retrotransposition, spermatogenesis, transposable element silencing by heterochromatin formation; MF: metal ion binding, protein binding, zinc ion binding; CC: male germ cell nucleus, nucleus
Pathways:
UniProt: Q86VD1
Entrez ID: 27136
|
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