prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of ELP2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | ELP2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ELP2 (elongator acetyltransferase complex subunit 2)
Type: protein-coding
Summary: The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effect... |
Does Knockout of TMEFF1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | TMEFF1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: TMEFF1 (transmembrane protein with EGF like and two follistatin like domains 1)
Type: protein-coding
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in animal organ morphogenesis; neuron projection development; and tissue development. Located in plasma me... |
Does Knockout of PLEKHA1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | PLEKHA1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: PLEKHA1 (pleckstrin homology domain containing A1)
Type: protein-coding
Summary: This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be... |
Does Knockout of SMC4 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | SMC4 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: SMC4 (structural maintenance of chromosomes 4)
Type: protein-coding
Summary: This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome cond... |
Does Knockout of TFAP2C in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | TFAP2C | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: TFAP2C (transcription factor AP-2 gamma)
Type: protein-coding
Summary: The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other fam... |
Does Knockout of DDX56 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | DDX56 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: DDX56 (DEAD-box helicase 56)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alterati... |
Does Knockout of SLC30A5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | SLC30A5 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SLC30A5 (solute carrier family 30 member 5)
Type: protein-coding
Summary: This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the ... |
Does Knockout of WDR48 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | WDR48 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: WDR48 (WD repeat domain 48)
Type: protein-coding
Summary: The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is... |
Does Knockout of TMEM127 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | TMEM127 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: TMEM127 (transmembrane protein 127)
Type: protein-coding
Summary: This gene encodes a transmembrane protein with four predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysoso... |
Does Knockout of FNTB in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | FNTB | cell proliferation | Breast Cancer Cell Line | Gene: FNTB (farnesyltransferase, CAAX box, subunit beta)
Type: protein-coding
Summary: Enables zinc ion binding activity. Contributes to protein farnesyltransferase activity. Involved in protein farnesylation. Part of microtubule associated complex and protein farnesyltransferase complex. [provided by A... |
Does Knockout of PROM1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | PROM1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: PROM1 (prominin 1)
Type: protein-coding
Summary: This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. M... |
Does Knockout of INTS11 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | INTS11 | cell proliferation | Cancer Cell Line | Gene: INTS11 (integrator complex subunit 11)
Type: protein-coding
Summary: The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 18... |
Does Knockout of ELP4 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | ELP4 | cell proliferation | Medulloblastoma Cell Line | Gene: ELP4 (elongator acetyltransferase complex subunit 4)
Type: protein-coding
Summary: This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially... |
Does Knockout of NCBP1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | NCBP1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: NCBP1 (nuclear cap binding protein subunit 1)
Type: protein-coding
Summary: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap... |
Does Knockout of EDN3 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | EDN3 | cell proliferation | Colonic Cancer Cell Line | Gene: EDN3 (endothelin 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from ... |
Does Knockout of WDR74 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | WDR74 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: WDR74 (WD repeat domain 74)
Type: protein-coding
Summary: Involved in rRNA processing and ribosomal large subunit biogenesis. Located in nucleoplasm. Colocalizes with nuclear exosome (RNase complex) and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA... |
Does Knockout of C10orf71 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | C10orf71 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: C10orf71 (chromosome 10 open reading frame 71)
Type: protein-coding
Summary: Predicted to be involved in positive regulation of calcineurin-NFAT signaling cascade. Predicted to be located in Z disc. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cardiac muscle cel... |
Does Knockout of PALB2 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | PALB2 | cell proliferation | Melanoma Cell Line | Gene: PALB2 (partner and localizer of BRCA2)
Type: protein-coding
Summary: This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localizatio... |
Does Knockout of MBD3L4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | MBD3L4 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: MBD3L4 (methyl-CpG binding domain protein 3 like 4)
Type: protein-coding
Summary: This gene encodes a member of a family of proteins that are related to methyl-CpG-binding proteins but lack the methyl-CpG binding domain. There is no definitive support for transcription of this locus, and the trans... |
Does Knockout of UTP20 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | UTP20 | cell proliferation | Neuroblastoma Cell Line | Gene: UTP20 (UTP20 small subunit processome component)
Type: protein-coding
Summary: UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009].
... |
Does Knockout of VMP1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | VMP1 | cell proliferation | Gastric Cancer Cell Line | Gene: VMP1 (vacuole membrane protein 1)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This g... |
Does Knockout of C6orf47 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | C6orf47 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: C6orf47 (chromosome 6 open reading frame 47)
Type: protein-coding
Summary: Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: O95873
Entrez ID: 57827 |
Does Knockout of DNALI1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | DNALI1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: DNALI1 (dynein axonemal light intermediate chain 1)
Type: protein-coding
Summary: This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural ... |
Does Knockout of TIPRL in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | TIPRL | cell proliferation | Renal Cancer Cell Line | Gene: TIPRL (TOR signaling pathway regulator)
Type: protein-coding
Summary: TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010].
... |
Does Knockout of FAM50A in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | FAM50A | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: FAM50A (family with sequence similarity 50 member A)
Type: protein-coding
Summary: This gene belongs to the FAM50 family. The encoded protein is highly conserved in length and sequence across different species. It is a basic protein containing a nuclear localization signal, and may function as a D... |
Does Knockout of CLN5 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | CLN5 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CLN5 (CLN5 lysosomal BMP synthase)
Type: protein-coding
Summary: This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The gen... |
Does Knockout of KDELR3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | KDELR3 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: KDELR3 (KDEL endoplasmic reticulum protein retention receptor 3)
Type: protein-coding
Summary: This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both y... |
Does Knockout of INHBC in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | INHBC | cell proliferation | Ewing's Sarcoma Cell Line | Gene: INHBC (inhibin subunit beta C)
Type: protein-coding
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The he... |
Does Knockout of CDC14B in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | CDC14B | cell proliferation | Renal Cancer Cell Line | Gene: CDC14B (cell division cycle 14B)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mit... |
Does Knockout of MS4A6A in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | MS4A6A | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: MS4A6A (membrane spanning 4-domains A6A)
Type: protein-coding
Summary: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression ... |
Does Knockout of TRAPPC1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | TRAPPC1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: TRAPPC1 (trafficking protein particle complex subunit 1)
Type: protein-coding
Summary: This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) ... |
Does Knockout of CINP in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | CINP | cell proliferation | Endometrial Cancer Cell Line | Gene: CINP (cyclin dependent kinase 2 interacting protein)
Type: protein-coding
Summary: The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been ... |
Does Knockout of ENTPD4 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | ENTPD4 | cell proliferation | Ovarian Cancer Cell Line | Gene: ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)
Type: protein-coding
Summary: This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded p... |
Does Knockout of ABCB7 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | ABCB7 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ABCB7 (ATP binding cassette subfamily B member 7)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC g... |
Does Knockout of GOLGA6A in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | GOLGA6A | cell proliferation | Ovarian Cancer Cell Line | Gene: GOLGA6A (golgin A6 family member A)
Type: protein-coding
Summary: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtub... |
Does Knockout of ALG6 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | ALG6 | cell proliferation | Hepatoma Cell Line | Gene: ALG6 (ALG6 alpha-1,3-glucosyltransferase)
Type: protein-coding
Summary: This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. M... |
Does Knockout of RAP2B in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | RAP2B | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: RAP2B (RAP2B, member of RAS oncogene family)
Type: protein-coding
Summary: This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common.... |
Does Knockout of UBE2E1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | UBE2E1 | cell proliferation | Colonic Cancer Cell Line | Gene: UBE2E1 (ubiquitin conjugating enzyme E2 E1)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating e... |
Does Knockout of PPCS in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | PPCS | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: PPCS (phosphopantothenoylcysteine synthetase)
Type: protein-coding
Summary: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate ... |
Does Knockout of RAD51D in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | RAD51D | cell proliferation | Hepatoma Cell Line | Gene: RAD51D (RAD51 paralog D)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair o... |
Does Knockout of SYVN1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | SYVN1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SYVN1 (synoviolin 1)
Type: protein-coding
Summary: This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ... |
Does Knockout of EIF1AD in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | EIF1AD | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: EIF1AD (eukaryotic translation initiation factor 1A domain containing)
Type: protein-coding
Summary: Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Allianc... |
Does Knockout of TFB1M in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | TFB1M | cell proliferation | Ovarian Cancer Cell Line | Gene: TFB1M (transcription factor B1, mitochondrial)
Type: protein-coding
Summary: The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessa... |
Does Knockout of LCE2D in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | LCE2D | cell proliferation | Cancer Cell Line | Gene: LCE2D (late cornified envelope 2D)
Type: protein-coding
Summary: Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epidermis development, keratinization
Pathways: Developmental Biology, Formation of the cornified e... |
Does Knockout of MRFAP1L1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | MRFAP1L1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: MRFAP1L1 (Morf4 family associated protein 1 like 1)
Type: protein-coding
Summary: Enables identical protein binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: identical protein binding, protein binding
Pathways:
UniProt: Q96HT8
... |
Does Knockout of SLC37A3 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | SLC37A3 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: SLC37A3 (solute carrier family 37 member 3)
Type: protein-coding
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in carbohydrate transport and transmembrane transport. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome... |
Does Knockout of POFUT1 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 1 | 1,480 | Knockout | POFUT1 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: POFUT1 (protein O-fucosyltransferase 1)
Type: protein-coding
Summary: This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of c... |
Does Knockout of LRGUK in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | LRGUK | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: LRGUK (leucine rich repeats and guanylate kinase domain containing)
Type: protein-coding
Summary: Predicted to enable guanylate kinase activity. Predicted to be involved in axoneme assembly and spermatogenesis. Predicted to be located in acrosomal vesicle and manchette. Predicted to be active in c... |
Does Knockout of SULF1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | SULF1 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: SULF1 (sulfatase 1)
Type: protein-coding
Summary: This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subseq... |
Does Knockout of PSMB7 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | PSMB7 | cell proliferation | Medulloblastoma Cell Line | Gene: PSMB7 (proteasome 20S subunit beta 7)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rin... |
Does Knockout of FOXA1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 1 | 1,996 | Knockout | FOXA1 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: FOXA1 (forkhead box A1)
Type: protein-coding
Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. S... |
Does Knockout of BYSL in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | BYSL | cell proliferation | Astrocytoma Cell Line | Gene: BYSL (bystin like)
Type: protein-coding
Summary: Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding... |
Does Knockout of PTH in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | PTH | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: PTH (parathyroid hormone)
Type: protein-coding
Summary: This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates bl... |
Does Knockout of GRAPL in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | GRAPL | cell proliferation | Monocytic Leukemia Cell Line | Gene: GRAPL (GRB2 related adaptor protein like)
Type: protein-coding
Summary: Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in cell migration and signal transduction. [provided by Alliance of Genome Resources, Apr 2022]
Ge... |
Does Knockout of STON1 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | STON1 | response to chemicals | Colorectal Cancer Cell Line | Gene: STON1 (stonin 1)
Type: protein-coding
Summary: Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is ... |
Does Knockout of NEUROG3 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | NEUROG3 | cell proliferation | Neuroblastoma Cell Line | Gene: NEUROG3 (neurogenin 3)
Type: protein-coding
Summary: The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabso... |
Does Knockout of TMEM229B in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | TMEM229B | cell proliferation | Gastric Cancer Cell Line | Gene: TMEM229B (transmembrane protein 229B)
Type: protein-coding
Summary: Predicted to act upstream of or within response to bacterium. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: macrophage activation, response to bact... |
Does Knockout of MED8 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | MED8 | cell proliferation | Medulloblastoma Cell Line | Gene: MED8 (mediator complex subunit 8)
Type: protein-coding
Summary: This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiqu... |
Does Knockout of TCOF1 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | TCOF1 | cell proliferation | Renal Cancer Cell Line | Gene: TCOF1 (treacle ribosome biogenesis factor 1)
Type: protein-coding
Summary: This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been ass... |
Does Knockout of MFSD11 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | MFSD11 | response to virus | Huh-7 Cell | Gene: MFSD11 (major facilitator superfamily domain containing 11)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: response to food, response to starvation
Pathways:
UniProt: ... |
Does Knockout of HMOX1 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | HMOX1 | response to virus | Hepatoma Cell Line | Gene: HMOX1 (heme oxygenase 1)
Type: protein-coding
Summary: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced... |
Does Knockout of LSM7 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | LSM7 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: LSM7 (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which c... |
Does Knockout of TET1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | TET1 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: TET1 (tet methylcytosine dioxygenase 1)
Type: protein-coding
Summary: DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protei... |
Does Knockout of RPIA in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | RPIA | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: RPIA (ribose 5-phosphate isomerase A)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The en... |
Does Knockout of UTP18 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | UTP18 | cell proliferation | Glioblastoma Cell Line | Gene: UTP18 (UTP18 small subunit processome component)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: rRNA p... |
Does Knockout of ZBTB20 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | ZBTB20 | cell proliferation | Gastric Cancer Cell Line | Gene: ZBTB20 (zinc finger and BTB domain containing 20)
Type: protein-coding
Summary: This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger dom... |
Does Knockout of UTP3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | UTP3 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: UTP3 (UTP3 small subunit processome component)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in brain development and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Geno... |
Does Knockout of PRTG in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | PRTG | response to chemicals | Melanoma Cell Line | Gene: PRTG (protogenin)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attentio... |
Does Knockout of MT2A in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | MT2A | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: MT2A (metallothionein 2A)
Type: protein-coding
Summary: This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentr... |
Does Knockout of ARR3 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | ARR3 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: ARR3 (arrestin 3)
Type: protein-coding
Summary: The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-c... |
Does Knockout of UNC13A in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | UNC13A | response to chemicals | Melanoma Cell Line | Gene: UNC13A (unc-13 homolog A)
Type: protein-coding
Summary: This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with spo... |
Does Knockout of TEX10 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | TEX10 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: TEX10 (testis expressed 10)
Type: protein-coding
Summary: Located in mitochondrion and nucleoplasm. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: MLL1 complex, cytoplasm, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways: Majo... |
Does Knockout of STRAP in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | STRAP | cell proliferation | Monocytic Leukemia Cell Line | Gene: STRAP (serine/threonine kinase receptor associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of transforming growth factor beta receptor signaling pathway; and spliceosomal snRNP assembly. Locate... |
Does Knockout of RCC1 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | RCC1 | cell proliferation | Multiple Myeloma Cell Line | Gene: RCC1 (regulator of chromosome condensation 1)
Type: protein-coding
Summary: Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in several processes, including G1/S transition of mitoti... |
Does Knockout of CAPN10 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | CAPN10 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: CAPN10 (calpain 10)
Type: protein-coding
Summary: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains... |
Does Knockout of SERPINH1 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | SERPINH1 | response to chemicals | Melanoma Cell Line | Gene: SERPINH1 (serpin family H member 1)
Type: protein-coding
Summary: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone... |
Does Knockout of CIAO1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | CIAO1 | cell proliferation | Bladder Carcinoma | Gene: CIAO1 (cytosolic iron-sulfur assembly component 1)
Type: protein-coding
Summary: Involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in cytoplasm. Part of CIA complex and MMXD complex. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of MAN1C1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | MAN1C1 | cell proliferation | Endometrial Cancer Cell Line | Gene: MAN1C1 (mannosidase alpha class 1C member 1)
Type: protein-coding
Summary: Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
G... |
Does Knockout of NCOA7 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | NCOA7 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: NCOA7 (nuclear receptor coactivator 7)
Type: protein-coding
Summary: Enables nuclear receptor binding activity and nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resour... |
Does Knockout of DEUP1 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | DEUP1 | response to virus | Huh-7 Cell | Gene: DEUP1 (deuterosome assembly protein 1)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Predicted to be located in cytoplasm. Predic... |
Does Knockout of ANKRD50 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | ANKRD50 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: ANKRD50 (ankyrin repeat domain containing 50)
Type: protein-coding
Summary: Involved in endocytic recycling. Predicted to be located in endosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endocytic recycling, protein transport
Pathways:
Uni... |
Does Knockout of PRELID3B in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | PRELID3B | cell proliferation | Medulloblastoma Cell Line | Gene: PRELID3B (PRELI domain containing 3B)
Type: protein-coding
Summary: Predicted to enable phosphatidic acid transfer activity. Predicted to be involved in phospholipid transport. Predicted to be active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of SRP19 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | SRP19 | cell proliferation | Colonic Cancer Cell Line | Gene: SRP19 (signal recognition particle 19)
Type: protein-coding
Summary: Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal... |
Does Knockout of TYROBP in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | TYROBP | response to virus | Hepatoma Cell Line | Gene: TYROBP (transmembrane immune signaling adaptor TYROBP)
Type: protein-coding
Summary: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inh... |
Does Knockout of USP10 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | USP10 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: USP10 (ubiquitin specific peptidase 10)
Type: protein-coding
Summary: Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzy... |
Does Knockout of TMEM135 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | TMEM135 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: TMEM135 (transmembrane protein 135)
Type: protein-coding
Summary: Predicted to be involved in peroxisome organization. Predicted to act upstream of or within response to cold and response to food. Predicted to be located in mitochondrion and peroxisome. [provided by Alliance of Genome Resources, A... |
Does Knockout of ZNF222 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | ZNF222 | response to chemicals | Glioblastoma Cell Line | Gene: ZNF222 (zinc finger protein 222)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of ZNF253 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | ZNF253 | cell proliferation | Breast Cancer Cell Line | Gene: ZNF253 (zinc finger protein 253)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-... |
Does Knockout of MIR1180 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | MIR1180 | response to virus | Hepatoma Cell Line | Gene: MIR1180 (microRNA 1180)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of SMARCA2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | SMARCA2 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: SMARCA2 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activi... |
Does Knockout of PPP1R10 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | PPP1R10 | cell proliferation | Colonic Cancer Cell Line | Gene: PPP1R10 (protein phosphatase 1 regulatory subunit 10)
Type: protein-coding
Summary: This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protei... |
Does Knockout of MAOA in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | MAOA | response to chemicals | Glioblastoma Cell Line | Gene: MAOA (monoamine oxidase A)
Type: protein-coding
Summary: This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome.... |
Does Knockout of GTF2E2 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | GTF2E2 | cell proliferation | Melanoma Cell Line | Gene: GTF2E2 (general transcription factor IIE subunit 2)
Type: protein-coding
Summary: The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer... |
Does Knockout of ONECUT1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | ONECUT1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ONECUT1 (one cut homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulat... |
Does Knockout of PPCDC in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | PPCDC | cell proliferation | Monocytic Leukemia Cell Line | Gene: PPCDC (phosphopantothenoylcysteine decarboxylase)
Type: protein-coding
Summary: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantoth... |
Does Knockout of MRO in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | MRO | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: MRO (maestro)
Type: protein-coding
Summary: This gene is specifically transcribed in males before and after differentiation of testis, and the encoded protein may play an important role in a mammalian sex determination. Multiple transcript variants encoding different isoforms have been found for t... |
Does Knockout of ELP2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | ELP2 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: ELP2 (elongator acetyltransferase complex subunit 2)
Type: protein-coding
Summary: The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effect... |
Does Knockout of COQ4 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | COQ4 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: COQ4 (coenzyme Q4)
Type: protein-coding
Summary: This gene encodes a component of the coenzyme Q biosynthesis pathway. Coenzyme Q, an essential component of the electron transport chain, shuttles electrons between complexes I or II to complex III of the mitochondrial transport chain. This protein ... |
Does Knockout of SNAPC2 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | SNAPC2 | cell proliferation | Prostate Cancer Cell Line | Gene: SNAPC2 (small nuclear RNA activating complex polypeptide 2)
Type: protein-coding
Summary: This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclea... |
Does Knockout of MORC1 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | MORC1 | response to chemicals | Monocytic Leukemia Cell Line | Gene: MORC1 (MORC family CW-type zinc finger 1)
Type: protein-coding
Summary: This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent... |
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