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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of HNRNPH1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
HNRNPH1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1)
Type: protein-coding
Summary: This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012].
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, regulation of RNA splicing; MF: RNA binding, identical protein binding, nucleic acid binding, poly(U) RNA binding, protein binding; CC: catalytic step 2 spliceosome, cytosol, membrane, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: FGFR2 alternative splicing, Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells, MECP2 and Associated Rett Syndrome, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Receptor Tyrosine Kinases, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P31943
Entrez ID: 3187
|
Does Knockout of RTL8B in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
RTL8B
|
response to virus
|
Lung Cancer Cell Line
|
Gene: RTL8B (retrotransposon Gag like 8B)
Type: protein-coding
Summary: Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q17RB0
Entrez ID: 441518
|
Does Knockout of NT5C1A in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
NT5C1A
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: NT5C1A (5'-nucleotidase, cytosolic IA)
Type: protein-coding
Summary: Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: AMP catabolic process, IMP catabolic process, adenosine metabolic process, allantoin metabolic process, dAMP catabolic process, dGMP catabolic process, nucleoside metabolic process, nucleotide metabolic process, purine nucleoside monophosphate catabolic process; MF: 5'-deoxynucleotidase activity, 5'-nucleotidase activity, hydrolase activity, magnesium ion binding, nucleotide binding, protein binding; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of nucleotides, Nicotinate and nicotinamide metabolism - Homo sapiens (human), Nucleotide catabolism, Purine catabolism, Purine metabolism - Homo sapiens (human), Pyrimidine catabolism, Pyrimidine metabolism - Homo sapiens (human), adenosine nucleotides degradation, purine nucleotides degradation
UniProt: Q9BXI3
Entrez ID: 84618
|
Does Knockout of MRPL35 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
MRPL35
|
cell proliferation
|
Melanoma Cell Line
|
Gene: MRPL35 (mitochondrial ribosomal protein L35)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9NZE8
Entrez ID: 51318
|
Does Knockout of PIP5K1A in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
PIP5K1A
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha)
Type: protein-coding
Summary: Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Located in several cellular components, including lamellipodium; nuclear speck; and ruffle membrane. Colocalizes with mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin cytoskeleton organization, activation of GTPase activity, cell chemotaxis, cell migration, fibroblast migration, focal adhesion assembly, glycerophospholipid metabolic process, keratinocyte differentiation, lipid metabolic process, phagocytosis, phosphatidylinositol biosynthetic process, phosphatidylinositol metabolic process, phosphatidylinositol phosphate biosynthetic process, phospholipid biosynthetic process, protein localization to plasma membrane, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, ruffle assembly, signal transduction; MF: 1-phosphatidylinositol-3-phosphate 5-kinase activity, 1-phosphatidylinositol-4-phosphate 5-kinase activity, 1-phosphatidylinositol-5-kinase activity, ATP binding, kinase activity, kinase binding, nucleotide binding, phosphatidylinositol kinase activity, protein binding, transferase activity; CC: cell projection, cytoplasm, cytosol, focal adhesion, lamellipodium, mRNA cleavage and polyadenylation specificity factor complex, membrane, nuclear speck, nucleoplasm, nucleus, plasma membrane, ruffle, ruffle membrane
Pathways: 3-phosphoinositide biosynthesis, Arf1 pathway, Arf6 downstream pathway, B Cell Receptor Signaling Pathway, BCR, Choline metabolism in cancer - Homo sapiens (human), D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, E-cadherin signaling in keratinocytes, Endocytosis - Homo sapiens (human), Fc gamma R-mediated phagocytosis - Homo sapiens (human), Focal adhesion - Homo sapiens (human), Inositol phosphate metabolism - Homo sapiens (human), Intracellular signaling by second messengers, Joubert syndrome, Metabolism, Metabolism of lipids, Negative regulation of the PI3K/AKT network, Osteopontin-mediated events, PI Metabolism, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Phosphatidylinositol Phosphate Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Phospholipid metabolism, RAC1 signaling pathway, Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), RhoA signaling pathway, Signal Transduction, Synthesis of PIPs at the plasma membrane, Yersinia infection - Homo sapiens (human), rho cell motility signaling pathway, superpathway of inositol phosphate compounds
UniProt: Q99755
Entrez ID: 8394
|
Does Knockout of CYP27C1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
CYP27C1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CYP27C1 (cytochrome P450 family 27 subfamily C member 1)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: alcohol metabolic process, lipid metabolic process, retinal metabolic process, retinoic acid metabolic process, retinol metabolic process; MF: 11-cis retinal binding, 11-cis-retinal 3,4-desaturase activity, all-trans retinal 3,4-desaturase activity, all-trans retinal binding, all-trans retinoic acid 3,4-desaturase activity, all-trans retinol 3,4-desaturase activity, all-trans-retinol binding, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, retinoic acid binding; CC: membrane, mitochondrial membrane, mitochondrion
Pathways: Metapathway biotransformation Phase I and II, Oxidation by Cytochrome P450, Retinol metabolism - Homo sapiens (human)
UniProt: Q4G0S4
Entrez ID: 339761
|
Does Activation of NUP188 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
NUP188
|
response to virus
|
Hepatoma Cell Line
|
Gene: NUP188 (nucleoporin 188)
Type: protein-coding
Summary: The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: RNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein import into nucleus, protein transport; MF: structural constituent of nuclear pore; CC: cytosol, membrane, nuclear envelope, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q5SRE5
Entrez ID: 23511
|
Does Activation of PDE4A in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
PDE4A
|
protein/peptide accumulation
|
T cell
|
Gene: PDE4A (phosphodiesterase 4A)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cAMP catabolic process, cellular response to xenobiotic stimulus, negative regulation of cAMP/PKA signal transduction, regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of cAMP/PKA signal transduction, sensory perception of smell, signal transduction; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cAMP binding, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity, protein binding; CC: cell projection, cytoplasm, cytosol, extrinsic component of membrane, membrane, nucleoplasm, perinuclear region of cytoplasm, plasma membrane, ruffle membrane
Pathways: G Protein Signaling Pathways, Morphine addiction - Homo sapiens (human), Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Phosphodiesterases in neuronal function, Purine metabolism - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human)
UniProt: P27815
Entrez ID: 5141
|
Does Knockout of RIC1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
RIC1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: RIC1 (RIC1 partner of RAB6A GEF complex)
Type: protein-coding
Summary: Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including positive regulation of GTPase activity; regulation of extracellular matrix constituent secretion; and retrograde transport, endosome to Golgi. Located in cytosol and membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cranial skeletal system development, intracellular protein transport, negative regulation of protein catabolic process, positive regulation of GTPase activity, regulation of extracellular matrix constituent secretion, retrograde transport, endosome to Golgi; MF: guanyl-nucleotide exchange factor activity, protein binding, small GTPase binding; CC: Golgi membrane, Ric1-Rgp1 guanyl-nucleotide exchange factor complex, cytoplasm, cytosol, membrane, protein-containing complex, trans-Golgi network membrane
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q4ADV7
Entrez ID: 57589
|
Does Knockout of TSSK3 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
TSSK3
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: TSSK3 (testis specific serine kinase 3)
Type: protein-coding
Summary: This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, protein phosphorylation, spermatid development, spermatogenesis; MF: ATP binding, kinase activity, magnesium ion binding, manganese ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell projection, cilium, motile cilium, sperm flagellum
Pathways:
UniProt: Q96PN8
Entrez ID: 81629
|
Does Knockout of VPS41 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
VPS41
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: VPS41 (VPS41 subunit of HOPS complex)
Type: protein-coding
Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi vesicle transport, autophagy, cellular response to starvation, endosomal vesicle fusion, endosome to lysosome transport, intracellular protein transport, late endosome to lysosome transport, macroautophagy, protein targeting to vacuole, protein transport, regulation of SNARE complex assembly, vesicle-mediated transport; MF: identical protein binding, metal ion binding, microtubule binding, protein binding, zinc ion binding; CC: AP-3 adaptor complex, Golgi apparatus, Golgi-associated vesicle, HOPS complex, clathrin complex, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, early endosome, early endosome membrane, endosome, endosome membrane, late endosome, late endosome membrane, lysosomal HOPS complex, lysosomal membrane, lysosome, membrane, microtubule cytoskeleton
Pathways: Disease, Ebola Virus Pathway on Host, Infectious disease, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates autophagy, SARS-CoV-2-host interactions, Salmonella infection - Homo sapiens (human), Viral Infection Pathways
UniProt: P49754
Entrez ID: 27072
|
Does Knockout of ARHGAP39 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
ARHGAP39
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ARHGAP39 (Rho GTPase activating protein 39)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Involved in postsynapse organization. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: postsynapse organization, regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity; CC: cytoplasm, cytoskeleton, cytosol, glutamatergic synapse, nucleus
Pathways: Axon guidance, CDC42 GTPase cycle, Developmental Biology, Inactivation of CDC42 and RAC1, Nervous system development, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by ROBO receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9C0H5
Entrez ID: 80728
|
Does Knockout of USP15 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
USP15
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: USP15 (ubiquitin specific peptidase 15)
Type: protein-coding
Summary: This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: BMP signaling pathway, monoubiquitinated protein deubiquitination, negative regulation of antifungal innate immune response, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of RIG-I signaling pathway, positive regulation of canonical NF-kappaB signal transduction, protein K27-linked deubiquitination, protein deubiquitination, proteolysis, regulation of RNA metabolic process, regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator, transcription elongation-coupled chromatin remodeling, transforming growth factor beta receptor signaling pathway; MF: K48-linked deubiquitinase activity, SMAD binding, catalytic activity, cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, identical protein binding, peptidase activity, protein binding, transforming growth factor beta receptor binding, ubiquitin-modified histone reader activity; CC: cytoplasm, cytosol, mitochondrion, nuclear body, nucleoplasm, nucleus
Pathways: Mitophagy - animal - Homo sapiens (human)
UniProt: Q9Y4E8
Entrez ID: 9958
|
Does Knockout of BOP1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
BOP1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: BOP1 (BOP1 ribosomal biogenesis factor)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in regulation of cell cycle; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. Part of PeBoW complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell population proliferation, cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of 5.8S rRNA, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, regulation of cell cycle, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding, ribonucleoprotein complex binding; CC: PeBoW complex, chromosome, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor, ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q14137
Entrez ID: 23246
|
Does Knockout of POR in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
POR
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: POR (cytochrome p450 oxidoreductase)
Type: protein-coding
Summary: This gene encodes an endoplasmic reticulum membrane oxidoreductase that is essential for multiple metabolic processes, including reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs and xenobiotics. The encoded protein has a flavin adenine dinucleotide (FAD)-binding domain and a flavodoxin-like domain which bind two cofactors, FAD and FMN, that allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene cause a complex set of disorders, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome, that resemble those caused by defects in steroid metabolizing enzymes such as aromatase, 21-hydroxylase, and 17 alpha-hydroxylase. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: carnitine metabolic process, cellular response to follicle-stimulating hormone stimulus, cellular response to gonadotropin stimulus, cellular response to peptide hormone stimulus, demethylation, electron transport chain, fatty acid oxidation, flavonoid metabolic process, negative regulation of apoptotic process, nitrate catabolic process, nitric oxide biosynthetic process, nitric oxide catabolic process, organofluorine metabolic process, positive regulation of chondrocyte differentiation, positive regulation of growth plate cartilage chondrocyte proliferation, positive regulation of smoothened signaling pathway, positive regulation of steroid hormone biosynthetic process, response to dexamethasone, response to hormone, response to nutrient, response to xenobiotic stimulus, xenobiotic metabolic process; MF: FMN binding, NADP binding, NADPH-hemoprotein reductase activity, cytochrome-b5 reductase activity, acting on NAD(P)H, electron transfer activity, enzyme activator activity, enzyme binding, flavin adenine dinucleotide binding, hydrolase activity, iron-cytochrome-c reductase activity, nitric oxide dioxygenase NAD(P)H activity, oxidoreductase activity, protein binding; CC: cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: 1,25-dihydroxyvitamin D<sub>3</sub> biosynthesis, Biological oxidations, Cytochrome P450 - arranged by substrate type, Doxorubicin Metabolism Pathway, Metabolism, Oxidation by Cytochrome P450, Phase I - Functionalization of compounds, bile acid biosynthesis, neutral pathway, melatonin degradation I, oxidative stress induced gene expression via nrf2, superpathway of melatonin degradation, superpathway of tryptophan utilization
UniProt: P16435
Entrez ID: 5447
|
Does Knockout of SERPINI2 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
SERPINI2
|
response to virus
|
Huh-7 Cell
|
Gene: SERPINI2 (serpin family I member 2)
Type: protein-coding
Summary: The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013].
Gene Ontology: MF: peptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity; CC: extracellular exosome, extracellular region, extracellular space
Pathways:
UniProt: O75830
Entrez ID: 5276
|
Does Knockout of AFG3L2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
AFG3L2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: AFG3L2 (AFG3 like matrix AAA peptidase subunit 2)
Type: protein-coding
Summary: This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: axonogenesis, calcium import into the mitochondrion, cellular response to glutathione, cristae formation, glutathione import into mitochondrion, membrane protein proteolysis, mitochondrial calcium ion homeostasis, mitochondrial fusion, mitochondrial protein processing, mitochondrial protein quality control, mitochondrion organization, muscle cell development, myelination, nerve development, neuromuscular junction development, protein autoprocessing, protein catabolic process, protein maturation, protein processing, proteolysis, regulation of calcium import into the mitochondrion, regulation of multicellular organism growth, righting reflex; MF: ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, nucleotide binding, peptidase activity, protein binding, unfolded protein binding, zinc ion binding; CC: m-AAA complex, membrane, mitochondrial inner membrane, mitochondrion
Pathways: Ciliary landscape, Metabolism of proteins, Mitochondrial calcium ion transport, Mitochondrial protein degradation, Processing of SMDT1, Spinocerebellar ataxia - Homo sapiens (human), Transport of small molecules
UniProt: Q9Y4W6
Entrez ID: 10939
|
Does Knockout of TMEM107 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
TMEM107
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: TMEM107 (transmembrane protein 107)
Type: protein-coding
Summary: This gene encodes a transmembrane protein and component of the primary cilia transition zone. The encoded protein regulates ciliogenesis and ciliary protein composition. Human fibroblasts expressing a mutant allele of this gene exhibit reduced numbers of cilia, altered cilia length, and impaired sonic hedgehog signaling. In human patients, different mutations in this gene cause different ciliopathies, including Meckel-Gruber syndrome and orofaciodigital syndrome. [provided by RefSeq, May 2017].
Gene Ontology: BP: cell projection organization, cilium assembly, cilium organization, craniofacial suture morphogenesis, detection of nodal flow, determination of left/right symmetry, embryonic digit morphogenesis, neural tube patterning, non-motile cilium assembly, protein localization to ciliary transition zone, regulation of gene expression, roof of mouth development; CC: MKS complex, cell projection, ciliary transition zone, cilium, membrane
Pathways: Ciliopathies, Genes related to primary cilium development (based on CRISPR)
UniProt: Q6UX40
Entrez ID: 84314
|
Does Knockout of ANK2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
ANK2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ANK2 (ankyrin 2)
Type: protein-coding
Summary: This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: SA node cell action potential, SA node cell to atrial cardiac muscle cell communication, T-tubule organization, atrial cardiac muscle cell action potential, atrial cardiac muscle cell to AV node cell communication, atrial septum development, cytoskeleton organization, endocytosis, intracellular calcium ion homeostasis, intracellular protein localization, membrane depolarization during SA node cell action potential, nervous system development, paranodal junction assembly, positive regulation of calcium ion transport, positive regulation of gene expression, positive regulation of potassium ion import across plasma membrane, protein localization to M-band, protein localization to T-tubule, protein localization to cell surface, protein localization to endoplasmic reticulum, protein localization to plasma membrane, protein stabilization, protein transport, regulation of SA node cell action potential, regulation of atrial cardiac muscle cell action potential, regulation of calcium ion transport, regulation of cardiac muscle cell contraction, regulation of cardiac muscle contraction, regulation of cardiac muscle contraction by calcium ion signaling, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of heart rate, regulation of heart rate by cardiac conduction, regulation of protein stability, regulation of release of sequestered calcium ion into cytosol, regulation of ventricular cardiac muscle cell membrane repolarization, response to methylmercury, sarcoplasmic reticulum calcium ion transport, signal transduction, ventricular cardiac muscle cell action potential; MF: ATPase binding, channel activator activity, cytoskeletal anchor activity, enzyme binding, phosphorylation-dependent protein binding, potassium channel activator activity, protein binding, protein kinase binding, protein-macromolecule adaptor activity, spectrin binding, structural constituent of cytoskeleton, transmembrane transporter binding; CC: A band, M band, T-tubule, Z disc, apical plasma membrane, basolateral plasma membrane, costamere, cytoplasm, cytoskeleton, cytosol, early endosome, endosome, intercalated disc, lysosome, membrane, mitochondrion, neuron projection, plasma membrane, postsynaptic membrane, recycling endosome, sarcolemma, synapse
Pathways: Asparagine N-linked glycosylation, Axon guidance, COPI-mediated anterograde transport, Developmental Biology, ER to Golgi Anterograde Transport, Interaction between L1 and Ankyrins, L1CAM interactions, Membrane Trafficking, Metabolism of proteins, Nervous system development, Post-translational protein modification, Proteoglycans in cancer - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q01484
Entrez ID: 287
|
Does Knockout of CELF4 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
CELF4
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: CELF4 (CUGBP Elav-like family member 4)
Type: protein-coding
Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, embryo development ending in birth or egg hatching, excitatory postsynaptic potential, germ cell development, in utero embryonic development, mRNA processing, mRNA splice site recognition, mRNA splicing, via spliceosome, negative regulation of excitatory postsynaptic potential, negative regulation of mRNA splicing, via spliceosome, negative regulation of translation, positive regulation of mRNA splicing, via spliceosome, regulation of alternative mRNA splicing, via spliceosome, regulation of retina development in camera-type eye; MF: BRE binding, RNA binding, mRNA binding, mRNA regulatory element binding translation repressor activity, nucleic acid binding, pre-mRNA binding, protein binding; CC: cytoplasm, nucleoplasm, nucleus, postsynapse, ribonucleoprotein complex
Pathways: mRNA Processing
UniProt: Q9BZC1
Entrez ID: 56853
|
Does Knockout of OR1J4 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
OR1J4
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: OR1J4 (olfactory receptor family 1 subfamily J member 4)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGS1
Entrez ID: 26219
|
Does Knockout of ADAMTSL2 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
ADAMTSL2
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: ADAMTSL2 (ADAMTS like 2)
Type: protein-coding
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. [provided by RefSeq, Feb 2009].
Gene Ontology: BP: extracellular matrix organization, lobar bronchus epithelium development, negative regulation of transforming growth factor beta receptor signaling pathway; MF: metalloendopeptidase activity, microfibril binding, protein binding; CC: extracellular matrix, extracellular region
Pathways: Defective B3GALTL causes PpS, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification, TGF-beta receptor signaling in skeletal dysplasias
UniProt: Q86TH1
Entrez ID: 9719
|
Does Knockout of PELP1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
PELP1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PELP1 (proline, glutamate and leucine rich protein 1)
Type: protein-coding
Summary: This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
Gene Ontology: BP: cellular response to estrogen stimulus, positive regulation of transcription by RNA polymerase II, rRNA processing; MF: RNA binding, SUMO binding, chromatin binding, protein binding; CC: MLL1 complex, cytoplasm, euchromatin, membrane, nucleolus, nucleoplasm, nucleus
Pathways: AndrogenReceptor, Coregulation of Androgen receptor activity, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nongenotropic Androgen signaling, PTK6 Expression, Plasma membrane estrogen receptor signaling, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, pelp1 modulation of estrogen receptor activity, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8IZL8
Entrez ID: 27043
|
Does Knockout of BRINP2 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
BRINP2
|
response to chemicals
|
Melanoma Cell Line
|
Gene: BRINP2 (BMP/retinoic acid inducible neural specific 2)
Type: protein-coding
Summary: Predicted to be involved in cellular response to retinoic acid; negative regulation of mitotic cell cycle; and positive regulation of neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in dendrite; endoplasmic reticulum; and neuronal cell body. Implicated in oral squamous cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to retinoic acid, central nervous system neuron differentiation, locomotion, multicellular organism growth, negative regulation of cell cycle, negative regulation of mitotic cell cycle, nervous system development, positive regulation of neuron differentiation, regulation of cell cycle; CC: cytoplasm, dendrite, extracellular region, neuronal cell body
Pathways:
UniProt: Q9C0B6
Entrez ID: 57795
|
Does Knockout of EML3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
EML3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: EML3 (EMAP like 3)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity. Involved in mitotic metaphase plate congression and regulation of mitotic spindle assembly. Located in several cellular components, including midbody; mitotic spindle microtubule; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, microtubule cytoskeleton organization, mitotic metaphase chromosome alignment, regulation of mitotic spindle assembly; MF: microtubule binding, protein binding; CC: cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, midbody, mitotic spindle, mitotic spindle microtubule, nucleus, spindle, spindle microtubule
Pathways:
UniProt: Q32P44
Entrez ID: 256364
|
Does Knockout of ZKSCAN5 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
ZKSCAN5
|
cell proliferation
|
Bladder Carcinoma
|
Gene: ZKSCAN5 (zinc finger with KRAB and SCAN domains 5)
Type: protein-coding
Summary: This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain and may be involved in transcriptional regulation. A similar protein in mouse is differentially expressed in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: negative regulation of macromolecule biosynthetic process, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q9Y2L8
Entrez ID: 23660
|
Does Knockout of ZNF131 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
ZNF131
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: ZNF131 (zinc finger protein 131)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: intermediate filament cytoskeleton, nucleoplasm, nucleus
Pathways:
UniProt: P52739
Entrez ID: 7690
|
Does Knockout of GRAMD1A in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
GRAMD1A
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: GRAMD1A (GRAM domain containing 1A)
Type: protein-coding
Summary: Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol. Located in cytosol; organelle membrane contact site; and plasma membrane. Is extrinsic component of cytoplasmic side of plasma membrane and intrinsic component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagy, cellular response to cholesterol, intracellular sterol transport, lipid transport; MF: cholesterol binding, cholesterol transfer activity, lipid binding, protein binding; CC: autophagosome, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, membrane, organelle membrane contact site, plasma membrane
Pathways:
UniProt: Q96CP6
Entrez ID: 57655
|
Does Knockout of CTCF in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
CTCF
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: CTCF (CCCTC-binding factor)
Type: protein-coding
Summary: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cardiac muscle cell development, cardiac muscle cell differentiation, chromatin looping, chromatin organization, chromosome segregation, epigenetic regulation of gene expression, gene expression, genomic imprinting, heart development, in utero embryonic development, mitochondrion organization, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, protein localization to chromosome, protein localization to chromosome, centromeric region, regulation of DNA-templated transcription, regulation of centromeric sister chromatid cohesion, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, chromatin insulator sequence binding, chromatin loop anchoring activity, cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coregulator binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, male germ cell nucleus, nucleolus, nucleoplasm, nucleus
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Developmental Biology, MECP2 and Associated Rett Syndrome, Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors, Prion disease pathway, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, TGF_beta_Receptor, ctcf: first multivalent nuclear factor
UniProt: P49711
Entrez ID: 10664
|
Does Knockout of HOXD3 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
HOXD3
|
cell proliferation
|
Cancer Cell Line
|
Gene: HOXD3 (homeobox D3)
Type: protein-coding
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, Notch signaling pathway, anterior/posterior pattern specification, cartilage development, cell-matrix adhesion, embryonic skeletal system morphogenesis, glossopharyngeal nerve morphogenesis, positive regulation of gene expression, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, thyroid gland development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: aggresome, chromatin, nuclear body, nucleoplasm, nucleus
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Developmental Biology
UniProt: P31249
Entrez ID: 3232
|
Does Knockout of ZSCAN29 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
ZSCAN29
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: ZSCAN29 (zinc finger and SCAN domain containing 29)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: Q8IWY8
Entrez ID: 146050
|
Does Knockout of RBBP8 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
RBBP8
|
cell proliferation
|
Cancer Cell Line
|
Gene: RBBP8 (RB binding protein 8, endonuclease)
Type: protein-coding
Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA double-strand break processing involved in repair via single-strand annealing, DNA repair, DNA strand resection involved in replication fork processing, G1/S transition of mitotic cell cycle, blastocyst hatching, cell division, double-strand break repair via homologous recombination, homologous recombination, meiotic cell cycle, mitotic G2/M transition checkpoint, negative regulation of DNA-templated transcription; MF: DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, damaged DNA binding, endonuclease activity, hydrolase activity, identical protein binding, metal ion binding, nuclease activity, protein binding, single-stranded DNA endodeoxyribonuclease activity, transcription corepressor activity; CC: BRCA1-C complex, chromosome, nucleoplasm, nucleus, site of double-strand break, transcription repressor complex
Pathways: ATM Signaling Network in Development and Disease, ATM pathway, BARD1 signaling events, E2F transcription factor network, Homologous recombination - Homo sapiens (human), Notch signaling pathway, Notch-mediated HES/HEY network, atm signaling pathway
UniProt: Q99708
Entrez ID: 5932
|
Does Knockout of PCBP2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
PCBP2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PCBP2 (poly(rC) binding protein 2)
Type: protein-coding
Summary: The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018].
Gene Ontology: BP: IRES-dependent viral translational initiation, cGAS/STING signaling pathway, chromatin looping, defense response to virus, immune system process, innate immune response, mRNA metabolic process, negative regulation of cGAS/STING signaling pathway, negative regulation of defense response to virus, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of transcription by RNA polymerase II, viral RNA genome replication; MF: DNA binding, RNA binding, enzyme binding, lncRNA binding, mRNA binding, nucleic acid binding, promoter-enhancer loop anchoring activity, protein binding, single-stranded DNA binding, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, extracellular exosome, focal adhesion, membrane, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: DDX58/IFIH1-mediated induction of interferon-alpha/beta, Disease, Ferroptosis, Ferroptosis - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Metabolism of RNA, Modulators of TCR signaling and T cell activation, Negative regulators of DDX58/IFIH1 signaling, Processing of Capped Intron-Containing Pre-mRNA, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 activates/modulates innate immune responses, SARS-CoV-1-host interactions, Viral Infection Pathways, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q15366
Entrez ID: 5094
|
Does Knockout of SDHAF1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
SDHAF1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SDHAF1 (succinate dehydrogenase complex assembly factor 1)
Type: protein-coding
Summary: The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).[provided by RefSeq, Mar 2010].
Gene Ontology: BP: mitochondrial respiratory chain complex II assembly; CC: mitochondrial matrix, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial CII Assembly
UniProt: A6NFY7
Entrez ID: 644096
|
Does Knockout of TENM1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
TENM1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: TENM1 (teneurin transmembrane protein 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: immune response, negative regulation of cell population proliferation, nervous system development, neuron development, neuropeptide signaling pathway, positive regulation of MAP kinase activity, positive regulation of actin filament polymerization, positive regulation of filopodium assembly, positive regulation of intracellular protein transport, positive regulation of peptidyl-serine phosphorylation, regulation of transcription by RNA polymerase III, signal transduction; MF: cell adhesion molecule binding, heparin binding, identical protein binding, protein heterodimerization activity, protein homodimerization activity; CC: Golgi apparatus, cytoplasm, cytoskeleton, endoplasmic reticulum, extracellular region, membrane, neuron projection, nuclear matrix, nuclear speck, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q9UKZ4
Entrez ID: 10178
|
Does Knockout of CDK1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
CDK1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: CDK1 (cyclin dependent kinase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA strand resection involved in replication fork processing, DNA synthesis involved in mitotic DNA replication, ERK1 and ERK2 cascade, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, Golgi disassembly, apoptotic process, cell division, cell migration, cellular response to hydrogen peroxide, centrosome cycle, chromatin remodeling, chromosome condensation, cilium disassembly, epithelial cell differentiation, fibroblast proliferation, microtubule cytoskeleton organization, microtubule cytoskeleton organization involved in mitosis, microtubule polymerization, mitotic DNA-templated DNA replication, mitotic G2 DNA damage checkpoint signaling, mitotic cell cycle phase transition, mitotic nuclear membrane disassembly, negative regulation of apoptotic process, negative regulation of gene expression, nuclear envelope organization, peptidyl-threonine phosphorylation, positive regulation of DNA replication, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cardiac muscle cell proliferation, positive regulation of gene expression, positive regulation of mitochondrial ATP synthesis coupled electron transport, positive regulation of mitotic sister chromatid segregation, positive regulation of protein import into nucleus, positive regulation of protein localization to nucleus, pronuclear fusion, protein deubiquitination, protein localization to kinetochore, protein localization to site of double-strand break, protein-containing complex assembly, regulation of Schwann cell differentiation, regulation of attachment of mitotic spindle microtubules to kinetochore, regulation of circadian rhythm, regulation of embryonic development, regulation of transcription by RNA polymerase II, response to activity, response to amine, response to axon injury, response to cadmium ion, response to copper ion, response to ethanol, response to hydrogen peroxide, response to toxic substance, rhythmic process, symbiont entry into host cell, thymidine biosynthetic process, ventricular cardiac muscle cell development; MF: ATP binding, Hsp70 protein binding, RNA polymerase II CTD heptapeptide repeat kinase activity, chromatin binding, cyclin binding, cyclin-dependent protein kinase activity, cyclin-dependent protein serine/threonine kinase activity, histone kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, virus receptor activity; CC: centrosome, chromosome, telomeric region, cyclin A1-CDK1 complex, cyclin A2-CDK1 complex, cyclin B1-CDK1 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum membrane, extracellular exosome, membrane, midbody, mitochondrial matrix, mitochondrion, mitotic spindle, nucleoplasm, nucleus, spindle, spindle microtubule
Pathways: AP-1 transcription factor network, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of mitotic proteins, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, ATM Signaling Network in Development and Disease, ATM Signaling Pathway, AURKA Activation by TPX2, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NIMA Kinases NEK9, NEK6, NEK7, Anchoring of the basal body to the plasma membrane, Antiviral mechanism by IFN-stimulated genes, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Centrosome maturation, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Cilium Assembly, Condensation of Prometaphase Chromosomes, Condensation of Prophase Chromosomes, Cyclin A/B1/B2 associated events during G2/M transition, Cytokine Signaling in Immune system, DNA damage response, Depolymerization of the Nuclear Lamina, Deubiquitination, E2F mediated regulation of DNA replication, E2F transcription factor network, E2F-enabled inhibition of pre-replication complex formation, EGFR1, FOXM1 transcription factor network, G0 and Early G1, G1 to S cell cycle control, G1/S Transition, G1/S-Specific Transcription, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M DNA replication checkpoint, G2/M Transition, Gap junction - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, Golgi Cisternae Pericentriolar Stack Reorganization, Human immunodeficiency virus 1 infection - Homo sapiens (human), Immune System, Initiation of Nuclear Envelope (NE) Reformation, Interferon Signaling, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK3 (ERK1) activation, MAPK6/MAPK4 signaling, MASTL Facilitates Mitotic Progression, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear Receptors Meta-Pathway, Oocyte meiosis - Homo sapiens (human), Organelle biogenesis and maintenance, Ovarian tumor domain proteases, PKR-mediated signaling, PLK1 signaling events, PPAR-alpha pathway, Phosphorylation of Emi1, Phosphorylation of the APC/C, Post-translational protein modification, Progesterone-mediated oocyte maturation - Homo sapiens (human), RAF-independent MAPK1/3 activation, RNA Polymerase II Transcription, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Microtubule Cytoskeleton, Regulation of PLK1 Activity at G2/M Transition, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of mitotic cell cycle, Resolution of Sister Chromatid Cohesion, Retinoblastoma gene in cancer, Retinoic acid receptors-mediated signaling, Signal Transduction, Spinal Cord Injury, TCR, TGF-beta Signaling Pathway, TGF_beta_Receptor, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1, Transcriptional Regulation by TP53, Transcriptional regulation by RUNX2, Viral carcinogenesis - Homo sapiens (human), akap95 role in mitosis and chromosome dynamics, cdc25 and chk1 regulatory pathway in response to dna damage, cell cycle: g1/s check point, cell cycle: g2/m checkpoint, cyclins and cell cycle regulation, estrogen responsive protein efp controls cell cycle and breast tumors growth, how progesterone initiates the oocyte maturation, miRNA regulation of DNA damage response, p53 signaling pathway - Homo sapiens (human), p73 transcription factor network, protein kinase a at the centrosome, rb tumor suppressor/checkpoint signaling in response to dna damage, regulation of cell cycle progression by plk3, regulation of splicing through sam68, sonic hedgehog receptor ptc1 regulates cell cycle, stathmin and breast cancer resistance to antimicrotubule agents
UniProt: P06493
Entrez ID: 983
|
Does Knockout of LETM1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
LETM1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: LETM1 (leucine zipper and EF-hand containing transmembrane protein 1)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: calcium export from the mitochondrion, calcium ion transport, cristae formation, inner mitochondrial membrane organization, mitochondrial calcium ion homeostasis, mitochondrial calcium ion transmembrane transport, mitochondrial potassium ion transmembrane transport, mitochondrion organization, monoatomic ion transport, negative regulation of mitochondrial calcium ion concentration, potassium ion transport, protein hexamerization, protein homooligomerization, proton transmembrane transport, regulation of cellular hyperosmotic salinity response; MF: antiporter activity, calcium ion binding, calcium:proton antiporter activity, metal ion binding, protein binding, ribosome binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex III assembly, Metabolism, Mitochondrial calcium ion transport, RHO GTPase cycle, RHOG GTPase cycle, Respiratory electron transport, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport of small molecules
UniProt: O95202
Entrez ID: 3954
|
Does Knockout of DRAM1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
DRAM1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: DRAM1 (DNA damage regulated autophagy modulator 1)
Type: protein-coding
Summary: This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, autophagy, cellular response to oxygen-glucose deprivation, regulation of autophagy; CC: cytoplasm, lysosomal membrane, lysosome, membrane
Pathways: p53 transcriptional gene network
UniProt: Q8N682
Entrez ID: 55332
|
Does Knockout of RUVBL2 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
RUVBL2
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: RUVBL2 (RuvB like AAA ATPase 2)
Type: protein-coding
Summary: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, box C/D snoRNP assembly, cellular response to UV, cellular response to estradiol stimulus, chromatin organization, chromatin remodeling, establishment of protein localization to chromatin, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, protein folding, protein stabilization, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of chromosome organization, regulation of double-strand break repair, regulation of embryonic development, regulation of transcription by RNA polymerase II, telomerase RNA localization to Cajal body, telomere maintenance; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATPase binding, DNA helicase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, TBP-class protein binding, TFIID-class transcription factor complex binding, beta-catenin binding, chromatin DNA binding, helicase activity, hydrolase activity, identical protein binding, nucleotide binding, promoter-enhancer loop anchoring activity, protein binding, protein homodimerization activity, transcription corepressor activity, unfolded protein binding; CC: Ino80 complex, MLL1 complex, NuA4 histone acetyltransferase complex, R2TP complex, RPAP3/R2TP/prefoldin-like complex, Swr1 complex, centrosome, ciliary basal body, cytoplasm, cytosol, dynein axonemal particle, euchromatin, extracellular exosome, membrane, nuclear matrix, nucleoplasm, nucleosome, nucleus, protein folding chaperone complex, ribonucleoprotein complex
Pathways: ATF-2 transcription factor network, C-MYC pathway, Cell Cycle, Chromatin modifying enzymes, Chromatin organization, Chromosome Maintenance, Extension of Telomeres, HATs acetylate histones, Integrin-linked kinase signaling, Regulation of nuclear beta catenin signaling and target gene transcription, Telomere Extension By Telomerase, Telomere Maintenance, Validated targets of C-MYC transcriptional activation
UniProt: Q9Y230
Entrez ID: 10856
|
Does Knockout of SESN2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
SESN2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: SESN2 (sestrin 2)
Type: protein-coding
Summary: This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: D-glucose import, DNA damage response, signal transduction by p53 class mediator, cellular oxidant detoxification, cellular response to L-leucine, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to glucose starvation, cellular response to leucine starvation, cellular response to nutrient levels, cellular response to oxidative stress, fatty acid beta-oxidation, glucose homeostasis, mitochondrial DNA metabolic process, mitochondrion organization, negative regulation of TORC1 signaling, negative regulation of cell growth, negative regulation of translation in response to endoplasmic reticulum stress, positive regulation of TORC1 signaling, positive regulation of lipophagy, positive regulation of macroautophagy, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to nucleus, protein K6-linked ubiquitination, protein K63-linked ubiquitination, reactive oxygen species metabolic process, regulation of TORC1 signaling, regulation of cAMP/PKA signal transduction, regulation of gluconeogenesis, regulation of protein phosphorylation, regulation of response to reactive oxygen species, response to glucose, response to insulin, triglyceride homeostasis; MF: GDP-dissociation inhibitor activity, L-leucine binding, PH domain binding, oxidoreductase activity, oxidoreductase activity, acting on peroxide as acceptor, peroxidase activity, protein binding, protein sequestering activity, protein-containing complex binding, sulfiredoxin activity; CC: Atg1/ULK1 kinase complex, TORC2 complex, cytoplasm, cytosol, lysosomal membrane, mitochondrion, nucleotide-activated protein kinase complex, nucleus
Pathways: Amino acids regulate mTORC1, Cellular response to chemical stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Gene expression (Transcription), Generic Transcription Pathway, Head and Neck Squamous Cell Carcinoma, KEAP1-NFE2L2 pathway, Longevity regulating pathway - Homo sapiens (human), RNA Polymerase II Transcription, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Homo sapiens (human), p53 signaling pathway - Homo sapiens (human), p53 transcriptional gene network
UniProt: P58004
Entrez ID: 83667
|
Does Knockout of NLE1 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
NLE1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: NLE1 (notchless homolog 1)
Type: protein-coding
Summary: Predicted to be involved in Notch signaling pathway and ribosomal large subunit assembly. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and regulation of signal transduction. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Notch signaling pathway, hematopoietic stem cell homeostasis, inner cell mass cell differentiation, kidney development, mitotic cell cycle, negative regulation of mitotic cell cycle, positive regulation of canonical Wnt signaling pathway, regulation of Notch signaling pathway, ribosomal large subunit biogenesis, skeletal system morphogenesis, somitogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9NVX2
Entrez ID: 54475
|
Does Knockout of IL18RAP in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
IL18RAP
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: IL18RAP (interleukin 18 receptor accessory protein)
Type: protein-coding
Summary: The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: adaptive immune response, cell population proliferation, cellular response to cytokine stimulus, cellular response to hydrogen peroxide, cellular response to interleukin-18, immune response, immune system process, inflammatory response, interleukin-18-mediated signaling pathway, neutrophil activation, positive regulation of NF-kappaB transcription factor activity, positive regulation of natural killer cell mediated cytotoxicity, signal transduction; MF: NAD+ nucleosidase activity, cyclic ADP-ribose generating, coreceptor activity, hydrolase activity, interleukin-18 receptor activity, protein binding, signaling receptor activity; CC: cell surface, interleukin-18 receptor complex, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), IL-18 signaling pathway, IL12 signaling mediated by STAT4, IL12-mediated signaling events, IL23-mediated signaling events, Immune System, Inflammatory bowel disease - Homo sapiens (human), Interleukin-1 family signaling, Interleukin-18 signaling, Signaling by Interleukins, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: O95256
Entrez ID: 8807
|
Does Knockout of ATP6V1E1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
ATP6V1E1
|
response to virus
|
Hepatoma Cell Line
|
Gene: ATP6V1E1 (ATPase H+ transporting V1 subunit E1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification; MF: ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, endosome, extracellular exosome, lysosomal membrane, membrane, microvillus, plasma membrane, proton-transporting two-sector ATPase complex, proton-transporting two-sector ATPase complex, catalytic domain, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, RANKL, ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, VEGFA-VEGFR2 Signaling Pathway, Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, mTOR signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: P36543
Entrez ID: 529
|
Does Knockout of CCDC172 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
CCDC172
|
response to virus
|
Hepatoma Cell Line
|
Gene: CCDC172 (coiled-coil domain containing 172)
Type: protein-coding
Summary: Predicted to be located in cytoplasm and sperm midpiece. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell projection, cilium, cytoplasm, sperm midpiece
Pathways:
UniProt: P0C7W6
Entrez ID: 374355
|
Does Knockout of KCNIP3 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
KCNIP3
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: KCNIP3 (potassium voltage-gated channel interacting protein 3)
Type: protein-coding
Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of transcription by RNA polymerase II, potassium ion transmembrane transport, potassium ion transport, protein localization to plasma membrane, regulation of potassium ion transmembrane transport, regulation of signal transduction, signal transduction; MF: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, calcium ion binding, metal ion binding, potassium channel activity, potassium channel regulator activity, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum, membrane, monoatomic ion channel complex, nucleus, plasma membrane, voltage-gated potassium channel complex
Pathways: Cardiac conduction, Gene expression (Transcription), Generic Transcription Pathway, IL3, Muscle contraction, Phase 1 - inactivation of fast Na+ channels, RNA Polymerase II Transcription, Regulation of NPAS4 gene expression, Regulation of NPAS4 gene transcription, Thyroid stimulating hormone (TSH) signaling pathway, Transcriptional Regulation by NPAS4, repression of pain sensation by the transcriptional regulator dream
UniProt: Q9Y2W7
Entrez ID: 30818
|
Does Knockout of MIEF2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
MIEF2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MIEF2 (mitochondrial elongation factor 2)
Type: protein-coding
Summary: This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: mitochondrial fusion, mitochondrion organization, positive regulation of mitochondrial fission, positive regulation of protein targeting to membrane, regulation of mitochondrion organization; CC: membrane, mitochondrial outer membrane, mitochondrion, peroxisome
Pathways:
UniProt: Q96C03
Entrez ID: 125170
|
Does Knockout of ALG1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
ALG1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase)
Type: protein-coding
Summary: The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. [provided by RefSeq, Dec 2008].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein glycosylation; MF: chitobiosyldiphosphodolichol beta-mannosyltransferase activity, glycosyltransferase activity, mannosyltransferase activity, transferase activity; CC: cytoplasmic side of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective ALG1 causes CDG-1k, Disease, Diseases associated with N-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), Nephrotic syndrome, Post-translational protein modification, Various types of N-glycan biosynthesis - Homo sapiens (human), dolichyl-diphosphooligosaccharide biosynthesis
UniProt: Q9BT22
Entrez ID: 56052
|
Does Knockout of SAP30BP in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
SAP30BP
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: SAP30BP (SAP30 binding protein)
Type: protein-coding
Summary: Involved in modulation by host of symbiont transcription; positive regulation of histone deacetylation; and response to virus. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, response to virus; CC: intermediate filament cytoskeleton, nucleoplasm, nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression
UniProt: Q9UHR5
Entrez ID: 29115
|
Does Knockout of PRPS2 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
PRPS2
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: PRPS2 (phosphoribosyl pyrophosphate synthetase 2)
Type: protein-coding
Summary: This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: 5-phosphoribose 1-diphosphate biosynthetic process, nucleobase-containing compound metabolic process, nucleotide biosynthetic process, pentose-phosphate shunt, purine nucleotide biosynthetic process, ribonucleoside monophosphate biosynthetic process; MF: ATP binding, identical protein binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, ribose phosphate diphosphokinase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: 5-Phosphoribose 1-diphosphate biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Nucleotide metabolism, PRPP biosynthesis, Pentose phosphate pathway, Pentose phosphate pathway - Homo sapiens (human), Purine metabolism - Homo sapiens (human)
UniProt: P11908
Entrez ID: 5634
|
Does Knockout of SELENOV in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
SELENOV
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: SELENOV (selenoprotein V)
Type: protein-coding
Summary: This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2017].
Gene Ontology:
Pathways: Selenium Micronutrient Network
UniProt: P59797
Entrez ID: 348303
|
Does Knockout of C1RL in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
C1RL
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: C1RL (complement C1r subcomponent like)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: complement activation, classical pathway, immune system process, innate immune response, proteolysis, zymogen activation; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: blood microparticle, extracellular exosome, extracellular region, extracellular space
Pathways:
UniProt: Q9NZP8
Entrez ID: 51279
|
Does Knockout of RHOG in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
RHOG
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: RHOG (ras homolog family member G)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: Rac protein signal transduction, Rho protein signal transduction, actin cytoskeleton organization, actin filament organization, activation of GTPase activity, cell chemotaxis, cortical cytoskeleton organization, establishment or maintenance of cell polarity, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of protein localization to plasma membrane, regulation of actin cytoskeleton organization, regulation of cell shape, regulation of postsynapse assembly, regulation of ruffle assembly, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding; CC: cell projection, cytoplasmic vesicle, cytoskeleton, cytosol, endoplasmic reticulum membrane, extracellular exosome, focal adhesion, glutamatergic synapse, membrane, plasma membrane, postsynapse, secretory granule membrane
Pathways: Bacterial invasion of epithelial cells - Homo sapiens (human), Brain-derived neurotrophic factor (BDNF) signaling pathway, Constitutive Signaling by Aberrant PI3K in Cancer, Disease, Diseases of signal transduction by growth factor receptors and second messengers, GPVI-mediated activation cascade, Hemostasis, Immune System, Innate Immune System, Integrin-linked kinase signaling, Intracellular signaling by second messengers, Negative regulation of the PI3K/AKT network, Neurotrophic factor-mediated Trk receptor signaling, Neutrophil degranulation, PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Platelet activation, signaling and aggregation, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate KTN1, RHOG GTPase cycle, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Yersinia infection - Homo sapiens (human)
UniProt: P84095
Entrez ID: 391
|
Does Knockout of RPS5 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
RPS5
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: RPS5 (ribosomal protein S5)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, regulation of translational fidelity, ribosomal small subunit biogenesis, translation, translational initiation; MF: RNA binding, mRNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46782
Entrez ID: 6193
|
Does Knockout of HS2ST1 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,391
|
Knockout
|
HS2ST1
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: HS2ST1 (heparan sulfate 2-O-sulfotransferase 1)
Type: protein-coding
Summary: Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: gene expression, heparan sulfate proteoglycan biosynthetic process, heparin proteoglycan metabolic process, ureteric bud formation; MF: heparan sulfate 2-sulfotransferase activity, protein binding, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human), Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metapathway biotransformation Phase I and II, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: Q7LGA3
Entrez ID: 9653
|
Does Knockout of BAMBI in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
BAMBI
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: BAMBI (BMP and activin membrane bound inhibitor)
Type: protein-coding
Summary: This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell migration, negative regulation of BMP signaling pathway, negative regulation of osteoblast differentiation, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of DNA-templated transcription, positive regulation of canonical Wnt signaling pathway, positive regulation of cell population proliferation, positive regulation of epithelial to mesenchymal transition, regulation of cell shape, transforming growth factor beta receptor signaling pathway; MF: frizzled binding, protein binding, type II transforming growth factor beta receptor binding; CC: cytoplasm, membrane, plasma membrane
Pathways: BMP receptor signaling, Downregulation of TGF-beta receptor signaling, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta Receptor Signaling, TGF-beta receptor signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in skeletal dysplasias, TGF-beta signaling pathway - Homo sapiens (human), Wnt signaling pathway - Homo sapiens (human)
UniProt: Q13145
Entrez ID: 25805
|
Does Knockout of KLC2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
KLC2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: KLC2 (kinesin light chain 2)
Type: protein-coding
Summary: The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: lysosome localization, microtubule-based movement; MF: cadherin binding, kinesin binding, protein binding; CC: cytoplasm, cytoskeleton, cytosol, kinesin I complex, kinesin complex, lysosomal membrane, lysosome, membrane, microtubule, mitochondrion, nucleoplasm, plasma membrane, protein-containing complex
Pathways: Adaptive Immune System, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), RHO GTPase Effectors, RHO GTPases activate KTN1, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q9H0B6
Entrez ID: 64837
|
Does Knockout of PTPN23 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
PTPN23
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PTPN23 (protein tyrosine phosphatase non-receptor type 23)
Type: protein-coding
Summary: This gene encodes a member of the non-receptor type protein-tyrosine phosphatase family. The encoded protein may be involved in the regulation of small nuclear ribonucleo protein assembly and pre-mRNA splicing by modifying the survival motor neuron (SMN) complex. The encoded protein additionally plays a role in ciliogenesis and is part of endosomal sorting complex required for transport (ESCRT) pathways. This gene may serve a tumor suppressor function. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: cell projection organization, cilium assembly, early endosome to late endosome transport, endocytic recycling, negative regulation of epithelial cell migration, positive regulation of Wnt protein secretion, positive regulation of adherens junction organization, positive regulation of early endosome to late endosome transport, positive regulation of homophilic cell adhesion, protein transport, protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; MF: hydrolase activity, phosphoprotein phosphatase activity, protein binding, protein kinase binding, protein tyrosine phosphatase activity; CC: cell projection, centriolar satellite, ciliary basal body, cilium, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, early endosome, endosome, extracellular exosome, nuclear body, nucleoplasm, nucleus
Pathways: Cytokine Signaling in Immune system, EGFR1, Immune System, Interleukin-1 family signaling, Interleukin-37 signaling, Signaling by Interleukins
UniProt: Q9H3S7
Entrez ID: 25930
|
Does Knockout of SLC17A3 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
SLC17A3
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: SLC17A3 (solute carrier family 17 member 3)
Type: protein-coding
Summary: The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: glucose-6-phosphate transport, monoatomic anion transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, organic anion transport, phosphate ion transport, sodium ion transmembrane transport, sodium ion transport, transmembrane transport, urate metabolic process, urate transport, xenobiotic detoxification by transmembrane export across the plasma membrane; MF: efflux transmembrane transporter activity, organic anion transmembrane transporter activity, sodium:phosphate symporter activity, symporter activity, toxin transmembrane transporter activity, transmembrane transporter activity, urate transmembrane transporter activity, voltage-gated monoatomic anion channel activity, xenobiotic transmembrane transporter activity; CC: apical plasma membrane, brush border membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: O00476
Entrez ID: 10786
|
Does Inhibition of MAPK14 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
MAPK14
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MAPK14 (mitogen-activated protein kinase 14)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, D-glucose import, DNA damage checkpoint signaling, DNA damage response, MAPK cascade, NLRP1 inflammasome complex assembly, angiogenesis, apoptotic process, bone development, cartilage condensation, cell morphogenesis, cell surface receptor protein serine/threonine kinase signaling pathway, cell surface receptor signaling pathway, cellular response to UV-B, cellular response to ionizing radiation, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to tumor necrosis factor, cellular response to vascular endothelial growth factor stimulus, cellular response to virus, cellular senescence, chemotaxis, chondrocyte differentiation, fatty acid oxidation, glucose metabolic process, intracellular signal transduction, lipopolysaccharide-mediated signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of hippo signaling, negative regulation of inflammatory response to antigenic stimulus, osteoblast differentiation, osteoclast differentiation, p38MAPK cascade, placenta development, platelet activation, positive regulation of D-glucose import, positive regulation of blood vessel endothelial cell migration, positive regulation of brown fat cell differentiation, positive regulation of cardiac muscle cell proliferation, positive regulation of cyclase activity, positive regulation of erythrocyte differentiation, positive regulation of gene expression, positive regulation of interleukin-12 production, positive regulation of muscle cell differentiation, positive regulation of myoblast differentiation, positive regulation of myoblast fusion, positive regulation of myotube differentiation, positive regulation of protein import into nucleus, positive regulation of reactive oxygen species metabolic process, positive regulation of transcription by RNA polymerase II, protein maturation, pyroptotic inflammatory response, regulation of DNA-templated transcription, regulation of cytokine production involved in inflammatory response, regulation of ossification, regulation of synaptic membrane adhesion, regulation of transcription by RNA polymerase II, response to dietary excess, response to insulin, response to lipopolysaccharide, response to muramyl dipeptide, response to muscle stretch, signal transduction, signal transduction in response to DNA damage, skeletal muscle tissue development, stem cell differentiation, stress-activated MAPK cascade, stress-activated protein kinase signaling cascade, stress-induced premature senescence, striated muscle cell differentiation, transcription by RNA polymerase II, tumor necrosis factor-mediated signaling pathway, vascular endothelial growth factor receptor signaling pathway; MF: ATP binding, MAP kinase activity, MAP kinase kinase activity, NFAT protein binding, enzyme binding, kinase activity, mitogen-activated protein kinase p38 binding, nucleotide binding, protein binding, protein kinase activity, protein phosphatase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, extracellular region, ficolin-1-rich granule lumen, glutamatergic synapse, mitochondrion, nuclear speck, nucleoplasm, nucleus, secretory granule lumen, spindle pole
Pathways: AGE-RAGE pathway, AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), ATF-2 transcription factor network, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alpha 6 Beta 4 signaling pathway, Alpha6Beta4Integrin, Amyotrophic lateral sclerosis (ALS), Amyotrophic lateral sclerosis - Homo sapiens (human), Angiogenesis, Angiopoietin Like Protein 8 Regulatory Pathway, Angiopoietin receptor Tie2-mediated signaling, Atypical NF-kappaB pathway, B Cell Receptor Signaling Pathway, BCR, BCR signaling pathway, Brain-derived neurotrophic factor (BDNF) signaling pathway, C-type lectin receptor signaling pathway - Homo sapiens (human), CD40/CD40L signaling, CDC42 signaling events, CRH, CXCR3-mediated signaling events, Canonical and non-canonical TGF-B signaling, Cardiac Hypertrophic Response, Cardiac Progenitor Differentiation, Cellular senescence - Homo sapiens (human), Chagas disease - Homo sapiens (human), Coronavirus disease - COVID-19 - Homo sapiens (human), Corticotropin-releasing hormone signaling pathway, Diabetic cardiomyopathy - Homo sapiens (human), Dopaminergic synapse - Homo sapiens (human), EGF-EGFR signaling pathway, EGFR1, EPO signaling pathway, Endothelins, Energy Metabolism, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Epithelial to mesenchymal transition in colorectal cancer, Epstein-Barr virus infection - Homo sapiens (human), Estrogen signaling pathway, FAS (CD95) signaling pathway, FGF signaling pathway, FGFR3 signaling in chondrocyte proliferation and terminal differentiation, Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), Fibroblast growth factor-1, Fluid shear stress and atherosclerosis - Homo sapiens (human), Follicle Stimulating Hormone (FSH) signaling pathway, FoxO signaling pathway - Homo sapiens (human), Gastrin, Gastrin signaling pathway, Glucocorticoid receptor regulatory network, GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C and Hepatocellular Carcinoma, Host-pathogen interaction of human coronaviruses - MAPK signaling, Host-pathogen interaction of human coronaviruses - apoptosis, Host-pathogen interaction of human coronaviruses - interferon induction, Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Hypothesized Pathways in Pathogenesis of Cardiovascular Disease, IL-1 signaling pathway, IL-17 signaling pathway - Homo sapiens (human), IL-4 signaling pathway, IL1, IL12-mediated signaling events, IL2, IL2-mediated signaling events, IL4, IL4-mediated signaling events, IL5, IL6, IL6-mediated signaling events, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Insulin Signaling, Interferon type I signaling pathways, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Kit receptor signaling pathway, KitReceptor, Leishmaniasis - Homo sapiens (human), Leptin, Leptin signaling pathway, Leukocyte transendothelial migration - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), MAPK Cascade, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, Monoamine Transport, NOD-like receptor signaling pathway - Homo sapiens (human), Netrin-UNC5B signaling pathway, Neuroinflammation, Neurotrophin signaling pathway - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), Non-genomic actions of 1,25 dihydroxyvitamin D3, Novel intracellular components of RIG-I-like receptor (RLR) pathway, Oncostatin M Signaling Pathway, Oocyte meiosis - Homo sapiens (human), Osteoblast differentiation, Osteoclast differentiation - Homo sapiens (human), Overview of leukocyte-intrinsic Hippo pathway functions, Oxidative Stress, PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), Parkinson,s disease pathway, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Pertussis - Homo sapiens (human), Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, Physiological and pathological hypertrophy of the heart, Platelet activation - Homo sapiens (human), Prion disease - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), Prolactin, Prolactin Signaling Pathway, Prolactin signaling pathway - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAC1 signaling pathway, RAC1-PAK1-p38-MMP2 Pathway, RAGE, RANKL, RANKL-RANK signaling pathway, RIG-I-like receptor signaling pathway - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Rapid glucocorticoid signaling, Regulation of Androgen receptor activity, Regulation of p38-alpha and p38-beta, Regulation of retinoblastoma protein, Regulation of toll-like receptor signaling pathway, Regulatory circuits of the STAT3 signaling pathway, Relaxin signaling pathway - Homo sapiens (human), Resistin as a regulator of inflammation, Retinoic acid receptors-mediated signaling, Retrograde endocannabinoid signaling - Homo sapiens (human), Role of Calcineurin-dependent NFAT signaling in lymphocytes, S1P2 pathway, Salmonella infection - Homo sapiens (human), Senescence and Autophagy in Cancer, Shigellosis - Homo sapiens (human), Signal transduction through IL1R, Signaling events mediated by VEGFR1 and VEGFR2, Signaling mediated by p38-alpha and p38-beta, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Sphingolipid signaling pathway - Homo sapiens (human), Structural Pathway of Interleukin 1 (IL-1), T cell receptor signaling pathway - Homo sapiens (human), T-cell receptor (TCR) signaling pathway, TCR, TGF-beta Signaling Pathway, TGF_beta_Receptor, TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, TNF signaling pathway - Homo sapiens (human), TNFalpha, TSLP, Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Thermogenesis, Thermogenesis - Homo sapiens (human), Thromboxane A2 receptor signaling, Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, Thyroid stimulating hormone (TSH) signaling pathway, Toll-like Receptor Signaling Pathway, Toll-like receptor signaling pathway - Homo sapiens (human), Toxoplasmosis - Homo sapiens (human), Translation inhibitors in chronically activated PDGFRA cells, Trk receptor signaling mediated by the MAPK pathway, Tuberculosis - Homo sapiens (human), VEGF signaling pathway - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, VEGFR3 signaling in lymphatic endothelium, Vitamin D in inflammatory diseases, Yersinia infection - Homo sapiens (human), bcr signaling pathway, bioactive peptide induced signaling pathway, control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk), fmlp induced chemokine gene expression in hmc-1 cells, gata3 participate in activating the th2 cytokine genes expression, human cytomegalovirus and map kinase pathways, il-10 anti-inflammatory signaling pathway, il12 and stat4 dependent signaling pathway in th1 development, keratinocyte differentiation, links between pyk2 and map kinases, map kinase inactivation of smrt corepressor, mapkinase signaling pathway, miRNAs involvement in the immune response in sepsis, nfkb activation by nontypeable hemophilus influenzae, p38 MAPK Signaling Pathway, p38 MAPK signaling pathway, p38 mapk signaling pathway, p38 signaling mediated by MAPKAP kinases, p53 pathway, p73 transcription factor network, regulation of eif-4e and p70s6 kinase, regulation of map kinase pathways through dual specificity phosphatases, signal transduction through il1r, the 41bb-dependent immune response, tnf/stress related signaling, toll-like receptor pathway, transcription factor creb and its extracellular signals, tsp-1 induced apoptosis in microvascular endothelial cell
UniProt: Q16539
Entrez ID: 1432
|
Does Knockout of ASF1B in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
ASF1B
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ASF1B (anti-silencing function 1B histone chaperone)
Type: protein-coding
Summary: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication-dependent chromatin assembly, blastocyst hatching, cell differentiation, chromatin organization, nucleosome assembly, spermatogenesis; MF: histone binding, histone chaperone activity, protein binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q9NVP2
Entrez ID: 55723
|
Does Knockout of WWC3 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
WWC3
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: WWC3 (WWC family member 3)
Type: protein-coding
Summary: This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: cell migration, hippo signaling, negative regulation of cell population proliferation, negative regulation of hippo signaling, negative regulation of organ growth, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of hippo signaling; MF: kinase binding, molecular adaptor activity, signaling adaptor activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q9ULE0
Entrez ID: 55841
|
Does Knockout of LAS1L in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
LAS1L
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: LAS1L (LAS1 like ribosome biogenesis factor)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in membrane. Part of MLL1 complex. Implicated in Wilson-Turner syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing; MF: RNA binding, endonuclease activity, hydrolase activity, protein binding; CC: Las1 complex, MLL1 complex, cytoplasm, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y4W2
Entrez ID: 81887
|
Does Activation of IKBKB in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
IKBKB
|
protein/peptide accumulation
|
T cell
|
Gene: IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta)
Type: protein-coding
Summary: The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: Fc-epsilon receptor signaling pathway, MyD88-dependent toll-like receptor signaling pathway, T cell receptor signaling pathway, TRIF-dependent toll-like receptor signaling pathway, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, canonical NF-kappaB signal transduction, cellular response to tumor necrosis factor, inflammatory response, innate immune response, interleukin-1-mediated signaling pathway, negative regulation of bicellular tight junction assembly, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cytokine production involved in inflammatory response, non-canonical NF-kappaB signal transduction, pattern recognition receptor signaling pathway, peptidyl-serine phosphorylation, positive regulation of DNA-templated transcription, positive regulation of NF-kappaB transcription factor activity, positive regulation of canonical NF-kappaB signal transduction, positive regulation of macromolecule metabolic process, positive regulation of transcription by RNA polymerase II, protein localization to plasma membrane, protein maturation, protein phosphorylation, protein polyubiquitination, regulation of establishment of endothelial barrier, regulation of toll-like receptor signaling pathway, regulation of transcription by RNA polymerase II, regulation of tumor necrosis factor-mediated signaling pathway, response to virus, signal transduction involved in regulation of gene expression, stimulatory C-type lectin receptor signaling pathway, stress-activated MAPK cascade, toll-like receptor 3 signaling pathway, tumor necrosis factor-mediated signaling pathway; MF: ATP binding, IkappaB kinase activity, identical protein binding, kinase activity, nucleotide binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, scaffold protein binding, transferase activity, transferrin receptor binding; CC: CD40 receptor complex, IkappaB kinase complex, cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane, membrane raft, nucleus
Pathways: AGE-RAGE pathway, Activation of NF-kappaB in B cells, Acute myeloid leukemia - Homo sapiens (human), Adaptive Immune System, Adipocytokine signaling pathway - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Antigen processing-Cross presentation, Antiviral mechanism by IFN-stimulated genes, Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis Modulation and Signaling, Atypical NF-kappaB pathway, Autosomal recessive Osteopetrosis pathways, B Cell Receptor Signaling Pathway, B cell receptor signaling pathway - Homo sapiens (human), BCR, BCR signaling pathway, Brain-derived neurotrophic factor (BDNF) signaling pathway, C-type lectin receptor signaling pathway - Homo sapiens (human), C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Canonical NF-KB pathway, Canonical NF-kappaB pathway, Cardiac Hypertrophic Response, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chagas disease - Homo sapiens (human), Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Chronic myeloid leukemia - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytokine Signaling in Immune system, Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, Death Receptor Signaling, Disease, Diseases associated with the TLR signaling cascade, Diseases of Immune System, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Ebstein-Barr virus LMP1 signaling, Endogenous TLR signaling, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), Estrogen signaling pathway, FAS (CD95) signaling pathway, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Fc-epsilon receptor I signaling in mast cells, Fibrin Complement Receptor 3 Signaling Pathway, Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, FoxO family signaling, FoxO signaling pathway - Homo sapiens (human), GMCSF-mediated signaling events, Gastrin signaling pathway, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Host-pathogen interaction of human coronaviruses - interferon induction, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IKBKB deficiency causes SCID, IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR), IKK complex recruitment mediated by RIP1, IL-1 signaling pathway, IL-17 signaling pathway - Homo sapiens (human), IL-18 signaling pathway, IL-4 signaling pathway, IL1, IL1-mediated signaling events, IL11, IL17 signaling pathway, IL4, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, IkBA variant leads to EDA-ID, Immune System, Infectious disease, Influenza A - Homo sapiens (human), Innate Immune System, Insulin Signaling, Insulin resistance - Homo sapiens (human), Insulin signaling pathway - Homo sapiens (human), Interferon Signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-11 Signaling Pathway, Interleukin-17 signaling, Intracellular Signalling Through Adenosine Receptor A2a and Adenosine, Intracellular Signalling Through Adenosine Receptor A2b and Adenosine, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Leptin, Leptin signaling pathway, Lipid and atherosclerosis - Homo sapiens (human), MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK Signaling Pathway, MAPK and NFkB signaling pathways inhibited by Yersinia YopJ, MAPK signaling pathway - Homo sapiens (human), Measles - Homo sapiens (human), MicroRNAs in cancer - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, Modulation of host responses by IFN-stimulated genes, Modulators of TCR signaling and T cell activation, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, NF-kB is activated and signals survival, NF-kappa B signaling pathway - Homo sapiens (human), NLR Proteins, NOD-like receptor signaling pathway - Homo sapiens (human), NOD1/2 Signaling Pathway, Neurotrophin signaling pathway - Homo sapiens (human), Non-alcoholic fatty liver disease - Homo sapiens (human), Non-genomic actions of 1,25 dihydroxyvitamin D3, Nonalcoholic fatty liver disease, Novel intracellular components of RIG-I-like receptor (RLR) pathway, Nucleotide-binding Oligomerization Domain (NOD) pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Osteoclast differentiation - Homo sapiens (human), Osteopontin Signaling, PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PKR-mediated signaling, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Photodynamic therapy-induced NF-kB survival signaling, Prostate cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, RAGE, RANKL, RANKL-RANK signaling pathway, RIG-I-like receptor signaling pathway - Homo sapiens (human), RIP-mediated NFkB activation via ZBP1, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of NF-kappa B signaling, Regulation of TNFR1 signaling, Regulation of toll-like receptor signaling pathway, Resistin as a regulator of inflammation, Response of endothelial cells to shear stress, Role of Altered Glycolysation of MUC1 in Tumour Microenvironment, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC15A4:TASL-dependent IRF5 activation, STING pathway in Kawasaki-like disease and COVID-19, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signal Transduction, Signal transduction through IL1R, Signaling by Interleukins, Signaling by the B Cell Receptor (BCR), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Structural Pathway of Interleukin 1 (IL-1), Supression of HMGB1 mediated inflammation by THBD, T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, T-cell receptor (TCR) signaling pathway, TAK1-dependent IKK and NF-kappa-B activation , TCR, TCR signaling, TCR signaling in naïve CD4+ T cells, TCR signaling in naïve CD8+ T cells, TICAM1, RIP1-mediated IKK complex recruitment, TNF receptor signaling pathway , TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, TNF signaling, TNF signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, TNFR1-induced NF-kappa-B signaling pathway, TNFalpha, TRAF6 mediated NF-kB activation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAIL signaling pathway, TRIF (TICAM1)-mediated TLR4 signaling , TSH, TWEAK, Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like Receptor Signaling Pathway, Toll-like Receptor Signaling related to MyD88, Toll-like receptor signaling pathway - Homo sapiens (human), Toxoplasmosis - Homo sapiens (human), Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Type II diabetes mellitus, Type II diabetes mellitus - Homo sapiens (human), Validated transcriptional targets of TAp63 isoforms, Viral Infection Pathways, Vitamin D in inflammatory diseases, Yersinia infection - Homo sapiens (human), ZBP1(DAI) mediated induction of type I IFNs, bone remodeling, ceramide signaling pathway, chaperones modulate interferon signaling pathway, double stranded rna induced gene expression, inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages, influence of ras and rho proteins on g1 to s transition, keratinocyte differentiation, mTOR signaling pathway, mTOR signaling pathway - Homo sapiens (human), mapkinase signaling pathway, miRNAs involvement in the immune response in sepsis, nf-kb signaling pathway, nfkb activation by nontypeable hemophilus influenzae, p75 NTR receptor-mediated signalling, p75(NTR)-mediated signaling, p75NTR recruits signalling complexes, p75NTR signals via NF-kB, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, signal transduction through il1r, tnf/stress related signaling, toll-like receptor pathway, trefoil factors initiate mucosal healing
UniProt: O14920
Entrez ID: 3551
|
Does Knockout of CHMP3 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
CHMP3
|
cell proliferation
|
Bladder Carcinoma
|
Gene: CHMP3 (charged multivesicular body protein 3)
Type: protein-coding
Summary: This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: apoptotic process, autophagosome maturation, autophagy, cell division, endosome to lysosome transport, endosome transport via multivesicular body sorting pathway, late endosome to lysosome transport, late endosome to vacuole transport, macroautophagy, membrane fission, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, positive regulation of cytokinesis, protein polymerization, protein transport, regulation of centrosome duplication, regulation of early endosome to late endosome transport, regulation of endosome size, regulation of exosomal secretion, regulation of mitotic spindle assembly, suppression of viral release by host, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex, viral release from host cell; MF: identical protein binding, molecular function inhibitor activity, phosphatidylcholine binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, ubiquitin-specific protease binding; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, cytoplasm, cytoplasmic vesicle, cytosol, early endosome, endosome, extracellular exosome, kinetochore, kinetochore microtubule, late endosome, late endosome membrane, lysosomal membrane, membrane, midbody, multivesicular body, multivesicular body membrane, nuclear pore, plasma membrane
Pathways: Endocytosis - Homo sapiens (human), Internalization of ErbB1, Necroptosis - Homo sapiens (human)
UniProt: Q9Y3E7
Entrez ID: 51652
|
Does Knockout of ALKBH5 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
ALKBH5
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: ALKBH5 (alkB homolog 5, RNA demethylase)
Type: protein-coding
Summary: Enables mRNA N6-methyladenosine dioxygenase activity. Involved in RNA metabolic process; mRNA export from nucleus; and response to hypoxia. Located in Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, gamma-delta T cell proliferation, mRNA destabilization, mRNA processing, membraneless organelle assembly, regulation of mRNA export from nucleus, regulation of mRNA processing, regulation of mRNA stability, regulation of translation, response to hypoxia, spermatogenesis; MF: 2-oxoglutarate-dependent dioxygenase activity, RNA binding, dioxygenase activity, mRNA N6-methyladenosine dioxygenase activity, metal ion binding, molecular condensate scaffold activity, oxidative RNA demethylase activity, oxidoreductase activity; CC: Golgi apparatus, cytosol, nuclear speck, nucleoplasm, nucleus, paraspeckles
Pathways: DNA Damage Reversal, DNA Repair, Reversal of alkylation damage by DNA dioxygenases
UniProt: Q6P6C2
Entrez ID: 54890
|
Does Knockout of HMGCS1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
HMGCS1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Type: protein-coding
Summary: Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: acetyl-CoA metabolic process, cholesterol biosynthetic process, cholesterol metabolic process, farnesyl diphosphate biosynthetic process, mevalonate pathway, isoprenoid biosynthetic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: acyltransferase activity, hydroxymethylglutaryl-CoA synthase activity, protein binding, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Activation of gene expression by SREBF (SREBP), Alendronate Action Pathway, Atorvastatin Action Pathway, Butanoate metabolism - Homo sapiens (human), CHILD Syndrome, Cerivastatin Action Pathway, Cholesterol Biosynthesis Pathway, Cholesterol biosynthesis, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Cholesteryl ester storage disease, Chondrodysplasia Punctata II, X Linked Dominant (CDPX2), Desmosterolosis, Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, FOXA2 and FOXA3 transcription factor networks, Fluvastatin Action Pathway, Hyper-IgD syndrome, Hypercholesterolemia, Ibandronate Action Pathway, Lovastatin Action Pathway, Lysosomal Acid Lipase Deficiency (Wolman Disease), Metabolism, Metabolism of lipids, Metabolism of steroids, Mevalonic aciduria, PPAR signaling pathway - Homo sapiens (human), PPARA activates gene expression, Pamidronate Action Pathway, Pravastatin Action Pathway, Regulation of cholesterol biosynthesis by SREBP (SREBF), Regulation of lipid metabolism by PPARalpha, Risedronate Action Pathway, Rosuvastatin Action Pathway, SREBF and miR33 in cholesterol and lipid homeostasis, Simvastatin Action Pathway, Smith-Lemli-Opitz Syndrome (SLOS), Steroid Biosynthesis, Sterol regulatory element-binding proteins (SREBP) signaling, Synthesis and degradation of ketone bodies - Homo sapiens (human), Terpenoid backbone biosynthesis - Homo sapiens (human), Valine, leucine and isoleucine degradation - Homo sapiens (human), Wolman disease, Zoledronate Action Pathway, ketogenesis, mevalonate pathway, srebp control of lipid synthesis, superpathway of cholesterol biosynthesis, superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
UniProt: Q01581
Entrez ID: 3157
|
Does Knockout of BUD13 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
BUD13
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: BUD13 (BUD13 spliceosome associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: RES complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9BRD0
Entrez ID: 84811
|
Does Knockout of LNPK in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
LNPK
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: LNPK (lunapark, ER junction formation factor)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in endoplasmic reticulum tubular network maintenance and positive regulation of endoplasmic reticulum tubular network organization. Located in endoplasmic reticulum tubular network membrane and nucleoplasm. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: blood coagulation, embryonic digit morphogenesis, embryonic forelimb morphogenesis, endoplasmic reticulum organization, endoplasmic reticulum tubular network maintenance, endoplasmic reticulum tubular network organization, limb development, positive regulation of endoplasmic reticulum tubular network organization, regulation of chondrocyte differentiation; MF: identical protein binding, metal ion binding, protein binding, zinc ion binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, endoplasmic reticulum tubular network membrane, membrane, nucleoplasm
Pathways:
UniProt: Q9C0E8
Entrez ID: 80856
|
Does Knockout of AKAP7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
AKAP7
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: AKAP7 (A-kinase anchoring protein 7)
Type: protein-coding
Summary: This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011].
Gene Ontology: BP: action potential, cellular response to cAMP, intracellular protein localization, intracellular signal transduction, modulation of chemical synaptic transmission, monoatomic ion transport, positive regulation of potassium ion transmembrane transport, regulation of membrane repolarization; MF: nucleotide binding, protein binding, protein kinase A binding, protein kinase A regulatory subunit binding, protein kinase binding; CC: apical plasma membrane, cytoplasm, cytosol, hippocampal mossy fiber to CA3 synapse, lateral plasma membrane, membrane, nucleus, plasma membrane, protein-containing complex
Pathways: G Protein Signaling Pathways
UniProt: Q9P0M2, O43687
Entrez ID: 9465
|
Does Knockout of IFNA13 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
IFNA13
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: IFNA13 (interferon alpha 13)
Type: protein-coding
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: Autoimmune thyroid disease - Homo sapiens (human), Coronavirus disease - COVID-19 - Homo sapiens (human), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), DDX58/IFIH1-mediated induction of interferon-alpha/beta, Disease, Downstream signaling in naïve CD8+ T cells, Epstein-Barr virus infection - Homo sapiens (human), Evasion by RSV of host interferon responses, Factors involved in megakaryocyte development and platelet production, Hemostasis, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Infectious disease, Influenza A - Homo sapiens (human), Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, JAK-STAT signaling pathway - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Measles - Homo sapiens (human), NOD-like receptor signaling pathway - Homo sapiens (human), Natural killer cell mediated cytotoxicity - Homo sapiens (human), Necroptosis - Homo sapiens (human), Overview of interferons-mediated signaling pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), RIG-I-like receptor signaling pathway - Homo sapiens (human), RSV-host interactions, Regulation of IFNA/IFNB signaling, Regulation of toll-like receptor signaling pathway, Respiratory Syncytial Virus Infection Pathway, SARS coronavirus and innate immunity, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, TRAF6 mediated IRF7 activation, Toll-like Receptor Signaling Pathway, Toll-like receptor signaling pathway - Homo sapiens (human), Tuberculosis - Homo sapiens (human), Viral Infection Pathways, double stranded rna induced gene expression, ifn alpha signaling pathway, signal transduction through il1r
UniProt: P01562
Entrez ID: 3447
|
Does Activation of CYP4F11 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
CYP4F11
|
protein/peptide accumulation
|
T cell
|
Gene: CYP4F11 (cytochrome P450 family 4 subfamily F member 11)
Type: protein-coding
Summary: This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: arachidonate metabolic process, blood coagulation, cytochrome metabolic process, fatty acid metabolic process, lipid metabolic process, menaquinone catabolic process, omega-hydroxylase P450 pathway, oxylipin biosynthetic process, phylloquinone catabolic process, vitamin K catabolic process; MF: arachidonate omega-hydroxylase activity, fatty acid binding, heme binding, iron ion binding, long-chain fatty acid omega-hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Arachidonate metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, Fatty acid metabolism, Fatty acids, Metabolism, Metabolism of lipids, Metapathway biotransformation Phase I and II, Miscellaneous substrates, Oxidation by Cytochrome P450, Phase I - Functionalization of compounds, Synthesis of Leukotrienes (LT) and Eoxins (EX)
UniProt: Q9HBI6
Entrez ID: 57834
|
Does Knockout of ITPA in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
ITPA
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: ITPA (inosine triphosphatase)
Type: protein-coding
Summary: This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: ITP catabolic process, chromosome organization, deoxyribonucleoside triphosphate catabolic process, nucleoside triphosphate catabolic process, nucleotide metabolic process; MF: ITP diphosphatase activity, XTP diphosphatase activity, dITP diphosphatase activity, hydrolase activity, identical protein binding, metal ion binding, nucleoside triphosphate diphosphatase activity, nucleotide binding; CC: cytoplasm, cytosol, nucleoplasm
Pathways: AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Beta Ureidopropionase Deficiency, Dihydropyrimidinase Deficiency, Drug ADME, Drug metabolism - other enzymes - Homo sapiens (human), Gout or Kelley-Seegmiller Syndrome, Lesch-Nyhan Syndrome (LNS), MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide catabolism, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine catabolism, Purine metabolism - Homo sapiens (human), Pyrimidine Metabolism, Ribavirin ADME, Thioguanine Action Pathway, UMP Synthase Deiciency (Orotic Aciduria), Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II
UniProt: Q9BY32
Entrez ID: 3704
|
Does Knockout of CTDSPL2 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
CTDSPL2
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: CTDSPL2 (CTD small phosphatase like 2)
Type: protein-coding
Summary: Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to act upstream of or within negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; and protein dephosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of BMP signaling pathway, positive regulation of protein export from nucleus, protein export from nucleus, regulation of transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat phosphatase activity, hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q05D32
Entrez ID: 51496
|
Does Knockout of GATC in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
GATC
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GATC (glutamyl-tRNA amidotransferase subunit C)
Type: protein-coding
Summary: Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined oxidative phosphorylation deficiency 42. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: glutaminyl-tRNAGln biosynthesis via transamidation, mitochondrial translation, regulation of translational fidelity, translation; MF: ATP binding, carbon-nitrogen ligase activity, with glutamine as amido-N-donor, glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, ligase activity, nucleotide binding, protein binding; CC: glutamyl-tRNA(Gln) amidotransferase complex, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human)
UniProt: O43716
Entrez ID: 283459
|
Does Knockout of PTGFR in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
PTGFR
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: PTGFR (prostaglandin F receptor)
Type: protein-coding
Summary: The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cellular response to prostaglandin D stimulus, inflammatory response, negative regulation of apoptotic process, parturition, positive regulation of cell population proliferation, positive regulation of cytosolic calcium ion concentration, positive regulation of gene expression, response to estradiol, response to lipid, response to lipopolysaccharide, signal transduction; MF: G protein-coupled receptor activity, prostaglandin F receptor activity; CC: cytoplasm, extracellular region, membrane, plasma membrane
Pathways: Calcium signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, Eicosanoid metabolism via cyclooxygenases (COX), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, GPCRs, Other, Neuroactive ligand-receptor interaction - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Prostaglandin Synthesis and Regulation, Prostanoid ligand receptors, Signal Transduction, Signaling by GPCR, Small Ligand GPCRs, eicosanoid metabolism
UniProt: P43088
Entrez ID: 5737
|
Does Knockout of SOX8 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
SOX8
|
response to chemicals
|
Melanoma Cell Line
|
Gene: SOX8 (SRY-box transcription factor 8)
Type: protein-coding
Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: Sertoli cell development, adipose tissue development, astrocyte fate commitment, cell fate commitment, cell maturation, enteric nervous system development, fat cell differentiation, in utero embryonic development, male gonad development, metanephric nephron tubule formation, morphogenesis of a branching epithelium, morphogenesis of an epithelium, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of myoblast differentiation, negative regulation of photoreceptor cell differentiation, negative regulation of transcription by RNA polymerase II, neural crest cell development, neural crest cell migration, oligodendrocyte differentiation, osteoblast differentiation, peripheral nervous system development, positive regulation of DNA-templated transcription, positive regulation of branching involved in ureteric bud morphogenesis, positive regulation of gene expression, positive regulation of gliogenesis, positive regulation of kidney development, positive regulation of osteoblast proliferation, positive regulation of transcription by RNA polymerase II, regulation of hormone levels, renal vesicle induction, retina development in camera-type eye, retinal rod cell differentiation, signal transduction, skeletal muscle cell differentiation, spermatogenesis, ureter morphogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytoplasm, nucleus, transcription regulator complex
Pathways: Mammalian disorder of sexual development, Pre-implantation embryo, Somatic sex determination
UniProt: P57073
Entrez ID: 30812
|
Does Knockout of ISCA2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
ISCA2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ISCA2 (iron-sulfur cluster assembly 2)
Type: protein-coding
Summary: The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: iron-sulfur cluster assembly, protein maturation; MF: 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, identical protein binding, iron ion binding, iron-sulfur cluster binding, metal ion binding, protein binding; CC: mitochondrial [4Fe-4S] assembly complex, mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis
UniProt: Q86U28
Entrez ID: 122961
|
Does Activation of EVI2A in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
EVI2A
|
response to virus
|
Hepatoma Cell Line
|
Gene: EVI2A (ecotropic viral integration site 2A)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, transmembrane signaling receptor activity; CC: Golgi apparatus, cilium, cytosol, membrane, plasma membrane
Pathways:
UniProt: P22794
Entrez ID: 2123
|
Does Knockout of CHEK1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
CHEK1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: CHEK1 (checkpoint kinase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, DNA replication, G2/M transition of mitotic cell cycle, apoptotic process, apoptotic process involved in development, cellular response to mechanical stimulus, chromatin remodeling, inner cell mass cell proliferation, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, mitotic nuclear membrane disassembly, negative regulation of G0 to G1 transition, negative regulation of cell cycle phase transition, negative regulation of gene expression, epigenetic, negative regulation of mitotic nuclear division, nuclear envelope organization, nucleus organization, peptidyl-threonine phosphorylation, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell cycle, protein phosphorylation, regulation of cell population proliferation, regulation of double-strand break repair via homologous recombination, regulation of gene expression, regulation of mitotic centrosome separation, regulation of signal transduction by p53 class mediator, replicative senescence, signal transduction in response to DNA damage; MF: ATP binding, histone H3T11 kinase activity, kinase activity, nucleotide binding, protein binding, protein domain specific binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, chromatin, chromosome, chromosome, telomeric region, condensed nuclear chromosome, cytoplasm, cytoskeleton, cytosol, extracellular space, nucleoplasm, nucleus, protein-containing complex, replication fork
Pathways: ATM Signaling Network in Development and Disease, ATR Signaling, ATR signaling pathway, Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, Cell cycle, Cell cycle - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Circadian rhythm pathway, DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, DNA damage response, Fanconi anemia pathway, G1/S DNA Damage Checkpoints, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Retinoblastoma gene in cancer, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by E2F6, Transcriptional Regulation by TP53, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Viral carcinogenesis - Homo sapiens (human), atm signaling pathway, cdc25 and chk1 regulatory pathway in response to dna damage, cell cycle: g2/m checkpoint, miRNA regulation of DNA damage response, p53 pathway, p53 signaling pathway - Homo sapiens (human), p53-Independent G1/S DNA Damage Checkpoint, p73 transcription factor network, rb tumor suppressor/checkpoint signaling in response to dna damage, regulation of cell cycle progression by plk3, role of brca1 brca2 and atr in cancer susceptibility
UniProt: O14757
Entrez ID: 1111
|
Does Knockout of TSPAN5 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
TSPAN5
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: TSPAN5 (tetraspanin 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: intracellular protein localization, positive regulation of Notch signaling pathway, protein localization to plasma membrane, protein maturation, regulation of membrane protein ectodomain proteolysis; MF: enzyme binding, protein binding; CC: endoplasmic reticulum lumen, membrane, nucleoplasm, plasma membrane
Pathways: Amyloid fiber formation, Metabolism of proteins
UniProt: P62079
Entrez ID: 10098
|
Does Knockout of SLC35A1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
SLC35A1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: SLC35A1 (solute carrier family 35 member A1)
Type: protein-coding
Summary: The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009].
Gene Ontology: BP: CMP-N-acetylneuraminate biosynthetic process, CMP-N-acetylneuraminate transmembrane transport, N-acetylneuraminate metabolic process, carbohydrate metabolic process, protein modification process, pyrimidine nucleotide-sugar transmembrane transport; MF: CMP-N-acetylneuraminate transmembrane transporter activity, antiporter activity, protein binding, pyrimidine nucleotide-sugar transmembrane transporter activity; CC: Golgi apparatus, Golgi membrane, membrane, plasma membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, DAG1 glycosylations, Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F), Disease, Disorders of transmembrane transporters, Matriglycan biosynthesis on DAG1, Metabolism of proteins, O-linked glycosylation, Post-translational protein modification, SLC transporter disorders, SLC-mediated transmembrane transport, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis, Transport of nucleotide sugars, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: P78382
Entrez ID: 10559
|
Does Knockout of EIF3H in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
EIF3H
|
cell proliferation
|
Melanoma Cell Line
|
Gene: EIF3H (eukaryotic translation initiation factor 3 subunit H)
Type: protein-coding
Summary: Enables deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of translational initiation, translation, translational initiation; MF: RNA binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, protein binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, extracellular exosome, membrane
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Measles - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, VEGFA-VEGFR2 Signaling Pathway, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: O15372
Entrez ID: 8667
|
Does Activation of RASL12 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
RASL12
|
response to virus
|
Hepatoma Cell Line
|
Gene: RASL12 (RAS like family 12)
Type: protein-coding
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding
Pathways:
UniProt: Q9NYN1
Entrez ID: 51285
|
Does Knockout of RPL37A in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
RPL37A
|
cell proliferation
|
Cancer Cell Line
|
Gene: RPL37A (ribosomal protein L37a)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, metal ion binding, protein binding, structural constituent of ribosome, zinc ion binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, nucleus, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P61513
Entrez ID: 6168
|
Does Knockout of GLMN in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
GLMN
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GLMN (glomulin, FKBP associated protein)
Type: protein-coding
Summary: This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cell surface receptor signaling pathway, circulatory system development, epigenetic regulation of gene expression, muscle cell differentiation, negative regulation of T cell proliferation, negative regulation of cell population proliferation, neural tube closure, positive regulation of cytokine production, positive regulation of interleukin-2 production, positive regulation of phosphorylation, regulation of proteasomal ubiquitin-dependent protein catabolic process, vasculogenesis; MF: hepatocyte growth factor receptor binding, protein binding, signaling receptor binding, ubiquitin protein ligase binding, ubiquitin-protein transferase inhibitor activity; CC: Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Shigellosis - Homo sapiens (human)
UniProt: Q92990
Entrez ID: 11146
|
Does Knockout of MRPL4 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
MRPL4
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: MRPL4 (mitochondrial ribosomal protein L4)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9BYD3
Entrez ID: 51073
|
Does Knockout of SLC25A44 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
SLC25A44
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SLC25A44 (solute carrier family 25 member 44)
Type: protein-coding
Summary: SLC25A44 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: amino acid transport, branched-chain amino acid catabolic process, branched-chain amino acid transport, regulation of cold-induced thermogenesis, transmembrane transport; MF: branched-chain amino acid transmembrane transporter activity; CC: membrane, mitochondrial membrane, mitochondrion
Pathways: Branched-chain amino acid catabolism, Metabolism, Metabolism of amino acids and derivatives
UniProt: Q96H78
Entrez ID: 9673
|
Does Knockout of CTSC in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
CTSC
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: CTSC (cathepsin C)
Type: protein-coding
Summary: This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: T cell mediated cytotoxicity, apoptotic process, immune response, negative regulation of myelination, positive regulation of apoptotic signaling pathway, positive regulation of microglial cell activation, positive regulation of proteolysis involved in protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: chloride ion binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, dipeptidyl-peptidase activity, hydrolase activity, identical protein binding, peptidase activator activity involved in apoptotic process, peptidase activity, phosphatase binding, protein binding, protein-folding chaperone binding, serine-type endopeptidase activity; CC: COPII-coated ER to Golgi transport vesicle, azurophil granule lumen, centrosome, cytoplasm, endoplasmic reticulum lumen, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular exosome, extracellular matrix, extracellular region, extracellular space, lysosome, membrane, nucleoplasm
Pathways: Adaptive Immune System, Apoptosis - Homo sapiens (human), Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, ER to Golgi Anterograde Transport, Immune System, Innate Immune System, Lysosome - Homo sapiens (human), MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P53634
Entrez ID: 1075
|
Does Knockout of HECTD1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
HECTD1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: HECTD1 (HECT domain E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in anatomical structure development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein K63-linked ubiquitination. Predicted to act upstream of or within several processes, including animal organ development; negative regulation of protein localization to plasma membrane; and protein autoubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: aorta development, heart valve development, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination, ubiquitin-dependent protein catabolic process, ventricular septum development; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q9ULT8
Entrez ID: 25831
|
Does Knockout of DIS3L2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
DIS3L2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)
Type: protein-coding
Summary: The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: cell division, mRNA catabolic process, miRNA catabolic process, mitotic cell cycle, mitotic sister chromatid separation, negative regulation of cell population proliferation, nuclear-transcribed mRNA catabolic process, polyuridylation-dependent mRNA catabolic process, stem cell population maintenance; MF: 3'-5'-RNA exonuclease activity, RNA binding, RNA nuclease activity, exonuclease activity, hydrolase activity, magnesium ion binding, metal ion binding, nuclease activity, poly(U) RNA binding, protein binding; CC: P-body, cytoplasm
Pathways: Developmental Biology, Maternal to zygotic transition (MZT), Z-decay: degradation of maternal mRNAs by zygotically expressed factors
UniProt: Q8IYB7
Entrez ID: 129563
|
Does Knockout of UTP14A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
UTP14A
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: UTP14A (UTP14A small subunit processome component)
Type: protein-coding
Summary: This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: rRNA processing, ribosome biogenesis; MF: RNA binding, protein binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9BVJ6
Entrez ID: 10813
|
Does Knockout of TRPV3 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
TRPV3
|
cell proliferation
|
Cancer Cell Line
|
Gene: TRPV3 (transient receptor potential cation channel subfamily V member 3)
Type: protein-coding
Summary: This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: actin filament organization, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of hair cycle, osmosensory signaling pathway, positive regulation of calcium ion import, response to temperature stimulus, sodium ion transmembrane transport, transmembrane transport; MF: calcium channel activity, identical protein binding, metal ion binding, monoatomic cation channel activity, monoatomic ion channel activity, protein binding, sodium channel activity; CC: cilium, cytoplasm, lysosome, membrane, plasma membrane, receptor complex
Pathways: Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Ion channel transport, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q8NET8
Entrez ID: 162514
|
Does Knockout of PKP4 in Lung Cancer Cell Line causally result in response to radiation?
| 1
| 1,952
|
Knockout
|
PKP4
|
response to radiation
|
Lung Cancer Cell Line
|
Gene: PKP4 (plakophilin 4)
Type: protein-coding
Summary: Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: cell adhesion, cell-cell adhesion, cell-cell junction assembly, cell-cell signaling, positive regulation of cytokinesis, regulation of Rho protein signal transduction, regulation of cell adhesion; MF: cadherin binding, protein binding; CC: adherens junction, anchoring junction, cell junction, cell-cell contact zone, cell-cell junction, cornified envelope, cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, desmosome, membrane, midbody, mitotic spindle, nucleus, organelle, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, spindle, spindle midzone, spindle pole
Pathways: EGFR1, Fibroblast growth factor-1, TCR
UniProt: Q99569
Entrez ID: 8502
|
Does Knockout of EXOSC6 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
EXOSC6
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: EXOSC6 (exosome component 6)
Type: protein-coding
Summary: This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA deamination, DNA metabolic process, RNA catabolic process, RNA processing, U4 snRNA 3'-end processing, isotype switching, nuclear mRNA surveillance, poly(A)-dependent snoRNA 3'-end processing, positive regulation of isotype switching, rRNA catabolic process, rRNA processing; MF: RNA binding, RNA exonuclease activity; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, exosome (RNase complex), nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Cellular responses to stimuli, Cellular responses to stress, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, PERK regulates gene expression, RNA degradation - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, Unfolded Protein Response (UPR), mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q5RKV6
Entrez ID: 118460
|
Does Knockout of NDC1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
NDC1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NDC1 (NDC1 transmembrane nucleoporin)
Type: protein-coding
Summary: A structural constituent of nuclear pore. Involved in nuclear pore complex assembly and nuclear pore localization. Located in actin cytoskeleton; nuclear membrane; and plasma membrane. Part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: homologous chromosome pairing at meiosis, mRNA transport, nuclear pore complex assembly, nuclear pore localization, nuclear pore organization, nucleocytoplasmic transport, protein transport, spermatogenesis; MF: protein-macromolecule adaptor activity, structural constituent of nuclear pore; CC: actin cytoskeleton, cytoplasm, membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore transmembrane ring, nucleus, plasma membrane
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q9BTX1
Entrez ID: 55706
|
Does Knockout of CCNK in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
CCNK
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: CCNK (cyclin K)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, cell division, host-mediated suppression of viral genome replication, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of cell cycle, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of signal transduction, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein binding, protein kinase binding; CC: cyclin K-CDK12 complex, cyclin K-CDK13 complex, cyclin-dependent protein kinase holoenzyme complex, cyclin/CDK positive transcription elongation factor complex, nucleoplasm, nucleus
Pathways: Direct p53 effectors, Male infertility
UniProt: O75909
Entrez ID: 8812
|
Does Knockout of TUBGCP5 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
TUBGCP5
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: TUBGCP5 (tubulin gamma complex component 5)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, spindle assembly; MF: gamma-tubulin binding, microtubule binding, microtubule minus-end binding, protein binding; CC: centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, gamma-tubulin complex, gamma-tubulin ring complex, microtubule, microtubule organizing center, spindle pole
Pathways: 15q11.2 copy number variation syndrome, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Prader-Willi and Angelman Syndrome, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes
UniProt: Q96RT8
Entrez ID: 114791
|
Does Knockout of CCR6 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
CCR6
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: CCR6 (C-C motif chemokine receptor 6)
Type: protein-coding
Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DN2 thymocyte differentiation, DN3 thymocyte differentiation, G protein-coupled receptor signaling pathway, T cell migration, calcium-mediated signaling, cell chemotaxis, cellular defense response, chemokine-mediated signaling pathway, chemotaxis, dendritic cell chemotaxis, humoral immune response, immune response, isotype switching to IgA isotypes, leukocyte migration involved in inflammatory response, lymphocyte migration, positive regulation of cytosolic calcium ion concentration, positive regulation of dendritic cell chemotaxis, positive regulation of flagellated sperm motility involved in capacitation, regulation of T cell migration, signal transduction, thymocyte migration; MF: C-C chemokine binding, C-C chemokine receptor activity, G protein-coupled receptor activity, chemokine receptor activity, protein binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane, sperm flagellum, sperm midpiece, sperm plasma membrane, sperm principal piece
Pathways: Antimicrobial peptides, Beta defensins, Chemokine receptors bind chemokines, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Homo sapiens (human), Defensins, G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Immune System, Innate Immune System, Peptide GPCRs, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: P51684
Entrez ID: 1235
|
Does Activation of DBH in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
DBH
|
response to virus
|
Hepatoma Cell Line
|
Gene: DBH (dopamine beta-hydroxylase)
Type: protein-coding
Summary: The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: associative learning, behavioral response to ethanol, blood vessel remodeling, catecholamine biosynthetic process, chemical synaptic transmission, dopamine catabolic process, fear response, glucose homeostasis, homoiothermy, leukocyte mediated immunity, leukocyte migration, locomotory behavior, maternal behavior, memory, norepinephrine biosynthetic process, octopamine biosynthetic process, positive regulation of cold-induced thermogenesis, positive regulation of vasoconstriction, regulation of extrinsic apoptotic signaling pathway, regulation of vascular associated smooth muscle cell proliferation, regulation of vascular endothelial cell proliferation, response to amphetamine, response to pain, vasoconstriction, visual learning; MF: L-ascorbic acid binding, catalytic activity, copper ion binding, dopamine beta-monooxygenase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen, protein binding; CC: centriolar satellite, chromaffin granule lumen, chromaffin granule membrane, cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, extracellular region, extracellular space, membrane, secretory granule lumen, secretory granule membrane, synapse, transport vesicle membrane
Pathways: Alkaptonuria, Amino Acid metabolism, Aromatic L-Aminoacid Decarboxylase Deficiency, Biogenic Amine Synthesis, Catecholamine Biosynthesis, Catecholamine biosynthesis, Disulfiram Action Pathway, Dopamine beta-hydroxylase deficiency, Hawkinsinuria, Metabolism, Metabolism of amine-derived hormones, Metabolism of amino acids and derivatives, Monoamine Transport, Monoamine oxidase-a deficiency (MAO-A), Tyrosine Metabolism, Tyrosine hydroxylase deficiency, Tyrosine metabolism - Homo sapiens (human), Tyrosinemia Type I, Tyrosinemia, transient, of the newborn, catecholamine biosynthesis
UniProt: P09172
Entrez ID: 1621
|
Does Knockout of FAM76B in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
FAM76B
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: FAM76B (family with sequence similarity 76 member B)
Type: protein-coding
Summary: Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mRNA stabilization, negative regulation of inflammatory response, negative regulation of macrophage activation, negative regulation of protein export from nucleus; MF: RNA binding, protein binding; CC: nuclear speck, nucleus
Pathways:
UniProt: Q5HYJ3
Entrez ID: 143684
|
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