prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of HNRNPH1 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | HNRNPH1 | cell proliferation | Colorectal Cancer Cell Line | Gene: HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1)
Type: protein-coding
Summary: This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins ... |
Does Knockout of RTL8B in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | RTL8B | response to virus | Lung Cancer Cell Line | Gene: RTL8B (retrotransposon Gag like 8B)
Type: protein-coding
Summary: Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q17RB0
Entrez ID: 441518 |
Does Knockout of NT5C1A in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | NT5C1A | cell proliferation | Gastric Cancer Cell Line | Gene: NT5C1A (5'-nucleotidase, cytosolic IA)
Type: protein-coding
Summary: Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: AMP catabolic process, IMP catabolic process,... |
Does Knockout of MRPL35 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | MRPL35 | cell proliferation | Melanoma Cell Line | Gene: MRPL35 (mitochondrial ribosomal protein L35)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of PIP5K1A in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | PIP5K1A | cell proliferation | Colorectal Cancer Cell Line | Gene: PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha)
Type: protein-coding
Summary: Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assem... |
Does Knockout of CYP27C1 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | CYP27C1 | cell proliferation | Glioblastoma Cell Line | Gene: CYP27C1 (cytochrome P450 family 27 subfamily C member 1)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, s... |
Does Activation of NUP188 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | NUP188 | response to virus | Hepatoma Cell Line | Gene: NUP188 (nucleoporin 188)
Type: protein-coding
Summary: The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively kno... |
Does Activation of PDE4A in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | PDE4A | protein/peptide accumulation | T cell | Gene: PDE4A (phosphodiesterase 4A)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to ex... |
Does Knockout of RIC1 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | RIC1 | cell proliferation | Multiple Myeloma Cell Line | Gene: RIC1 (RIC1 partner of RAB6A GEF complex)
Type: protein-coding
Summary: Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including positive regulation of GTPase activity; regulation of extracellular matrix constituent secretion; an... |
Does Knockout of TSSK3 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | TSSK3 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: TSSK3 (testis specific serine kinase 3)
Type: protein-coding
Summary: This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differe... |
Does Knockout of VPS41 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | VPS41 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: VPS41 (VPS41 subunit of HOPS complex)
Type: protein-coding
Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in ve... |
Does Knockout of ARHGAP39 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | ARHGAP39 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ARHGAP39 (Rho GTPase activating protein 39)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Involved in postsynapse organization. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: postsynapse organizati... |
Does Knockout of USP15 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | USP15 | cell proliferation | Monocytic Leukemia Cell Line | Gene: USP15 (ubiquitin specific peptidase 15)
Type: protein-coding
Summary: This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of u... |
Does Knockout of BOP1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | BOP1 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: BOP1 (BOP1 ribosomal biogenesis factor)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in regulation of cell cycle; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. Part of PeBo... |
Does Knockout of POR in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | POR | response to virus | Cervical Adenocarcinoma Cell Line | Gene: POR (cytochrome p450 oxidoreductase)
Type: protein-coding
Summary: This gene encodes an endoplasmic reticulum membrane oxidoreductase that is essential for multiple metabolic processes, including reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs and xenobiot... |
Does Knockout of SERPINI2 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | SERPINI2 | response to virus | Huh-7 Cell | Gene: SERPINI2 (serpin family I member 2)
Type: protein-coding
Summary: The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, mali... |
Does Knockout of AFG3L2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | AFG3L2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: AFG3L2 (AFG3 like matrix AAA peptidase subunit 2)
Type: protein-coding
Summary: This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gen... |
Does Knockout of TMEM107 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | TMEM107 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: TMEM107 (transmembrane protein 107)
Type: protein-coding
Summary: This gene encodes a transmembrane protein and component of the primary cilia transition zone. The encoded protein regulates ciliogenesis and ciliary protein composition. Human fibroblasts expressing a mutant allele of this gene exhi... |
Does Knockout of ANK2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | ANK2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ANK2 (ankyrin 2)
Type: protein-coding
Summary: This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and th... |
Does Knockout of CELF4 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | CELF4 | response to chemicals | Colorectal Cancer Cell Line | Gene: CELF4 (CUGBP Elav-like family member 4)
Type: protein-coding
Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this pro... |
Does Knockout of OR1J4 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | OR1J4 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: OR1J4 (olfactory receptor family 1 subfamily J member 4)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of ADAMTSL2 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | ADAMTSL2 | response to chemicals | Colorectal Cancer Cell Line | Gene: ADAMTSL2 (ADAMTS like 2)
Type: protein-coding
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metallopro... |
Does Knockout of PELP1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | PELP1 | cell proliferation | Gastric Cancer Cell Line | Gene: PELP1 (proline, glutamate and leucine rich protein 1)
Type: protein-coding
Summary: This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. ... |
Does Knockout of BRINP2 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | BRINP2 | response to chemicals | Melanoma Cell Line | Gene: BRINP2 (BMP/retinoic acid inducible neural specific 2)
Type: protein-coding
Summary: Predicted to be involved in cellular response to retinoic acid; negative regulation of mitotic cell cycle; and positive regulation of neuron differentiation. Predicted to be located in extracellular region. Predic... |
Does Knockout of EML3 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | EML3 | cell proliferation | Colonic Cancer Cell Line | Gene: EML3 (EMAP like 3)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity. Involved in mitotic metaphase plate congression and regulation of mitotic spindle assembly. Located in several cellular components, including midbody; mitotic spindle microtubule; and nucleus. [provi... |
Does Knockout of ZKSCAN5 in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | ZKSCAN5 | cell proliferation | Bladder Carcinoma | Gene: ZKSCAN5 (zinc finger with KRAB and SCAN domains 5)
Type: protein-coding
Summary: This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain and may be involved in transcriptional regulation. A similar protein in mouse is differentially expres... |
Does Knockout of ZNF131 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | ZNF131 | cell proliferation | Renal Cancer Cell Line | Gene: ZNF131 (zinc finger protein 131)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA b... |
Does Knockout of GRAMD1A in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | GRAMD1A | cell proliferation | Medulloblastoma Cell Line | Gene: GRAMD1A (GRAM domain containing 1A)
Type: protein-coding
Summary: Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol. Located in cytosol; organelle membrane contact site; and plasma membrane. Is extrinsic... |
Does Knockout of CTCF in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | CTCF | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: CTCF (CCCTC-binding factor)
Type: protein-coding
Summary: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind di... |
Does Knockout of HOXD3 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | HOXD3 | cell proliferation | Cancer Cell Line | Gene: HOXD3 (homeobox D3)
Type: protein-coding
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene ... |
Does Knockout of ZSCAN29 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | ZSCAN29 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: ZSCAN29 (zinc finger and SCAN domain containing 29)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resour... |
Does Knockout of RBBP8 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | RBBP8 | cell proliferation | Cancer Cell Line | Gene: RBBP8 (RB binding protein 8, endonuclease)
Type: protein-coding
Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with tr... |
Does Knockout of PCBP2 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | PCBP2 | cell proliferation | Colonic Cancer Cell Line | Gene: PCBP2 (poly(rC) binding protein 2)
Type: protein-coding
Summary: The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involv... |
Does Knockout of SDHAF1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | SDHAF1 | cell proliferation | Colonic Cancer Cell Line | Gene: SDHAF1 (succinate dehydrogenase complex assembly factor 1)
Type: protein-coding
Summary: The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essen... |
Does Knockout of TENM1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | TENM1 | cell proliferation | Ovarian Cancer Cell Line | Gene: TENM1 (teneurin transmembrane protein 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding... |
Does Knockout of CDK1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | CDK1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: CDK1 (cyclin dependent kinase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M ... |
Does Knockout of LETM1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | LETM1 | cell proliferation | Colonic Cancer Cell Line | Gene: LETM1 (leucine zipper and EF-hand containing transmembrane protein 1)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphol... |
Does Knockout of DRAM1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | DRAM1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: DRAM1 (DNA damage regulated autophagy modulator 1)
Type: protein-coding
Summary: This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of... |
Does Knockout of RUVBL2 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | RUVBL2 | cell proliferation | Multiple Myeloma Cell Line | Gene: RUVBL2 (RuvB like AAA ATPase 2)
Type: protein-coding
Summary: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene produ... |
Does Knockout of SESN2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | SESN2 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: SESN2 (sestrin 2)
Type: protein-coding
Summary: This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by ... |
Does Knockout of NLE1 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | NLE1 | cell proliferation | Renal Cancer Cell Line | Gene: NLE1 (notchless homolog 1)
Type: protein-coding
Summary: Predicted to be involved in Notch signaling pathway and ribosomal large subunit assembly. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and regulation... |
Does Knockout of IL18RAP in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | IL18RAP | RNA accumulation | Monocytic Leukemia Cell Line | Gene: IL18RAP (interleukin 18 receptor accessory protein)
Type: protein-coding
Summary: The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18... |
Does Knockout of ATP6V1E1 in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | ATP6V1E1 | response to virus | Hepatoma Cell Line | Gene: ATP6V1E1 (ATPase H+ transporting V1 subunit E1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intr... |
Does Knockout of CCDC172 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | CCDC172 | response to virus | Hepatoma Cell Line | Gene: CCDC172 (coiled-coil domain containing 172)
Type: protein-coding
Summary: Predicted to be located in cytoplasm and sperm midpiece. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell projection, cilium, cytoplasm, sperm midpiece
Pathways:
UniPro... |
Does Knockout of KCNIP3 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | KCNIP3 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: KCNIP3 (potassium voltage-gated channel interacting protein 3)
Type: protein-coding
Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calc... |
Does Knockout of MIEF2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | MIEF2 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: MIEF2 (mitochondrial elongation factor 2)
Type: protein-coding
Summary: This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface... |
Does Knockout of ALG1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | ALG1 | cell proliferation | Colonic Cancer Cell Line | Gene: ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase)
Type: protein-coding
Summary: The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. [provid... |
Does Knockout of SAP30BP in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | SAP30BP | cell proliferation | Astrocytoma Cell Line | Gene: SAP30BP (SAP30 binding protein)
Type: protein-coding
Summary: Involved in modulation by host of symbiont transcription; positive regulation of histone deacetylation; and response to virus. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Apr... |
Does Knockout of PRPS2 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | PRPS2 | response to chemicals | Colorectal Cancer Cell Line | Gene: PRPS2 (phosphoribosyl pyrophosphate synthetase 2)
Type: protein-coding
Summary: This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from AT... |
Does Knockout of SELENOV in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | SELENOV | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: SELENOV (selenoprotein V)
Type: protein-coding
Summary: This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec ... |
Does Knockout of C1RL in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | C1RL | cell proliferation | Glioblastoma Cell Line | Gene: C1RL (complement C1r subcomponent like)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: complemen... |
Does Knockout of RHOG in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | RHOG | cell proliferation | Glioblastoma Cell Line | Gene: RHOG (ras homolog family member G)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization... |
Does Knockout of RPS5 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | RPS5 | cell proliferation | Ovarian Cancer Cell Line | Gene: RPS5 (ribosomal protein S5)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ... |
Does Knockout of HS2ST1 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,391 | Knockout | HS2ST1 | response to chemicals | Non-Small Cell Lung Adenocarcinoma Cell Line | Gene: HS2ST1 (heparan sulfate 2-O-sulfotransferase 1)
Type: protein-coding
Summary: Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate bi... |
Does Knockout of BAMBI in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | BAMBI | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: BAMBI (BMP and activin membrane bound inhibitor)
Type: protein-coding
Summary: This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental an... |
Does Knockout of KLC2 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | KLC2 | cell proliferation | Medulloblastoma Cell Line | Gene: KLC2 (kinesin light chain 2)
Type: protein-coding
Summary: The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN... |
Does Knockout of PTPN23 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | PTPN23 | cell proliferation | Colonic Cancer Cell Line | Gene: PTPN23 (protein tyrosine phosphatase non-receptor type 23)
Type: protein-coding
Summary: This gene encodes a member of the non-receptor type protein-tyrosine phosphatase family. The encoded protein may be involved in the regulation of small nuclear ribonucleo protein assembly and pre-mRNA splicing... |
Does Knockout of SLC17A3 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | SLC17A3 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: SLC17A3 (solute carrier family 17 member 3)
Type: protein-coding
Summary: The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been foun... |
Does Inhibition of MAPK14 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,184 | Inhibition | MAPK14 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: MAPK14 (mitogen-activated protein kinase 14)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation... |
Does Knockout of ASF1B in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | ASF1B | cell proliferation | Colonic Cancer Cell Line | Gene: ASF1B (anti-silencing function 1B histone chaperone)
Type: protein-coding
Summary: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of c... |
Does Knockout of WWC3 in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | WWC3 | RNA accumulation | Monocytic Leukemia Cell Line | Gene: WWC3 (WWC family member 3)
Type: protein-coding
Summary: This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the r... |
Does Knockout of LAS1L in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | LAS1L | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: LAS1L (LAS1 like ribosome biogenesis factor)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in membrane. Part of MLL1 complex. Implicated in Wilson-Turner syndrome. [provided by Alliance of Genome ... |
Does Activation of IKBKB in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | IKBKB | protein/peptide accumulation | T cell | Gene: IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta)
Type: protein-coding
Summary: The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found i... |
Does Knockout of CHMP3 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | CHMP3 | cell proliferation | Bladder Carcinoma | Gene: CHMP3 (charged multivesicular body protein 3)
Type: protein-coding
Summary: This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESC... |
Does Knockout of ALKBH5 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | ALKBH5 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: ALKBH5 (alkB homolog 5, RNA demethylase)
Type: protein-coding
Summary: Enables mRNA N6-methyladenosine dioxygenase activity. Involved in RNA metabolic process; mRNA export from nucleus; and response to hypoxia. Located in Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome... |
Does Knockout of HMGCS1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | HMGCS1 | cell proliferation | Glioblastoma Cell Line | Gene: HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Type: protein-coding
Summary: Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytoplasm. Predicted to... |
Does Knockout of BUD13 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | BUD13 | cell proliferation | Colonic Cancer Cell Line | Gene: BUD13 (BUD13 spliceosome associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RN... |
Does Knockout of LNPK in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | LNPK | response to virus | Cervical Adenocarcinoma Cell Line | Gene: LNPK (lunapark, ER junction formation factor)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in endoplasmic reticulum tubular network maintenance and positive regulation of endoplasmic reticulum tubular network organization. Located in endoplasmic reticulum tubu... |
Does Knockout of AKAP7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | AKAP7 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: AKAP7 (A-kinase anchoring protein 7)
Type: protein-coding
Summary: This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific... |
Does Knockout of IFNA13 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | IFNA13 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: IFNA13 (interferon alpha 13)
Type: protein-coding
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation o... |
Does Activation of CYP4F11 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | CYP4F11 | protein/peptide accumulation | T cell | Gene: CYP4F11 (cytochrome P450 family 4 subfamily F member 11)
Type: protein-coding
Summary: This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of chol... |
Does Knockout of ITPA in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | ITPA | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: ITPA (inosine triphosphatase)
Type: protein-coding
Summary: This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1... |
Does Knockout of CTDSPL2 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | CTDSPL2 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: CTDSPL2 (CTD small phosphatase like 2)
Type: protein-coding
Summary: Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to act upstream of or within negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; and protein dephosph... |
Does Knockout of GATC in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | GATC | cell proliferation | Monocytic Leukemia Cell Line | Gene: GATC (glutamyl-tRNA amidotransferase subunit C)
Type: protein-coding
Summary: Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidot... |
Does Knockout of PTGFR in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | PTGFR | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: PTGFR (prostaglandin F receptor)
Type: protein-coding
Summary: The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modula... |
Does Knockout of SOX8 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | SOX8 | response to chemicals | Melanoma Cell Line | Gene: SOX8 (SRY-box transcription factor 8)
Type: protein-coding
Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcript... |
Does Knockout of ISCA2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | ISCA2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ISCA2 (iron-sulfur cluster assembly 2)
Type: protein-coding
Summary: The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants en... |
Does Activation of EVI2A in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | EVI2A | response to virus | Hepatoma Cell Line | Gene: EVI2A (ecotropic viral integration site 2A)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, transmembrane signaling receptor activity; CC: Golgi apparatus, cilium, cytoso... |
Does Knockout of CHEK1 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | CHEK1 | cell proliferation | Melanoma Cell Line | Gene: CHEK1 (checkpoint kinase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals fr... |
Does Knockout of TSPAN5 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | TSPAN5 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: TSPAN5 (tetraspanin 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The protei... |
Does Knockout of SLC35A1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | SLC35A1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: SLC35A1 (solute carrier family 35 member A1)
Type: protein-coding
Summary: The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the e... |
Does Knockout of EIF3H in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | EIF3H | cell proliferation | Melanoma Cell Line | Gene: EIF3H (eukaryotic translation initiation factor 3 subunit H)
Type: protein-coding
Summary: Enables deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiati... |
Does Activation of RASL12 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | RASL12 | response to virus | Hepatoma Cell Line | Gene: RASL12 (RAS like family 12)
Type: protein-coding
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
G... |
Does Knockout of RPL37A in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | RPL37A | cell proliferation | Cancer Cell Line | Gene: RPL37A (ribosomal protein L37a)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene enco... |
Does Knockout of GLMN in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | GLMN | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: GLMN (glomulin, FKBP associated protein)
Type: protein-coding
Summary: This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenou... |
Does Knockout of MRPL4 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | MRPL4 | cell proliferation | Breast Cancer Cell Line | Gene: MRPL4 (mitochondrial ribosomal protein L4)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. T... |
Does Knockout of SLC25A44 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | SLC25A44 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: SLC25A44 (solute carrier family 25 member 44)
Type: protein-coding
Summary: SLC25A44 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: amino acid transport, branched-chain amino acid cata... |
Does Knockout of CTSC in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | CTSC | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: CTSC (cathepsin C)
Type: protein-coding
Summary: This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transc... |
Does Knockout of HECTD1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | HECTD1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: HECTD1 (HECT domain E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in anatomical structure development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein K63-li... |
Does Knockout of DIS3L2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | DIS3L2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)
Type: protein-coding
Summary: The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several t... |
Does Knockout of UTP14A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | UTP14A | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: UTP14A (UTP14A small subunit processome component)
Type: protein-coding
Summary: This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogene... |
Does Knockout of TRPV3 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | TRPV3 | cell proliferation | Cancer Cell Line | Gene: TRPV3 (transient receptor potential cation channel subfamily V member 3)
Type: protein-coding
Summary: This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of t... |
Does Knockout of PKP4 in Lung Cancer Cell Line causally result in response to radiation? | 1 | 1,952 | Knockout | PKP4 | response to radiation | Lung Cancer Cell Line | Gene: PKP4 (plakophilin 4)
Type: protein-coding
Summary: Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their ... |
Does Knockout of EXOSC6 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | EXOSC6 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: EXOSC6 (exosome component 6)
Type: protein-coding
Summary: This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast M... |
Does Knockout of NDC1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | NDC1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: NDC1 (NDC1 transmembrane nucleoporin)
Type: protein-coding
Summary: A structural constituent of nuclear pore. Involved in nuclear pore complex assembly and nuclear pore localization. Located in actin cytoskeleton; nuclear membrane; and plasma membrane. Part of nuclear pore. [provided by Alliance o... |
Does Knockout of CCNK in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | CCNK | cell proliferation | Colorectal Cancer Cell Line | Gene: CCNK (cyclin K)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of ... |
Does Knockout of TUBGCP5 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | TUBGCP5 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: TUBGCP5 (tubulin gamma complex component 5)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: B... |
Does Knockout of CCR6 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | CCR6 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: CCR6 (C-C motif chemokine receptor 6)
Type: protein-coding
Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and ... |
Does Activation of DBH in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | DBH | response to virus | Hepatoma Cell Line | Gene: DBH (dopamine beta-hydroxylase)
Type: protein-coding
Summary: The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, ca... |
Does Knockout of FAM76B in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | FAM76B | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: FAM76B (family with sequence similarity 76 member B)
Type: protein-coding
Summary: Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mRNA stabilization, negative regulation of inflammatory response, negative regulation of macrophage activati... |
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