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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of TMEM97 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
TMEM97
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TMEM97 (transmembrane protein 97)
Type: protein-coding
Summary: TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009].
Gene Ontology: BP: cholesterol homeostasis, positive regulation of lipoprotein transport, positive regulation of wound healing, regulation of cell growth, regulation of intracellular cholesterol transport, regulation of intracellular lipid transport; MF: cholesterol binding, oxysterol binding, protein binding; CC: endoplasmic reticulum, lysosome, membrane, nuclear membrane, nucleus, plasma membrane, rough endoplasmic reticulum, rough endoplasmic reticulum membrane
Pathways:
UniProt: Q5BJF2
Entrez ID: 27346
|
Does Knockout of TUSC1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
TUSC1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: TUSC1 (tumor suppressor candidate 1)
Type: protein-coding
Summary: This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways:
UniProt: Q2TAM9
Entrez ID: 286319
|
Does Knockout of ZNF418 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
ZNF418
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: ZNF418 (zinc finger protein 418)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: microautophagy, negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: Q8TF45
Entrez ID: 147686
|
Does Activation of GPHA2 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
GPHA2
|
response to virus
|
Hepatoma Cell Line
|
Gene: GPHA2 (glycoprotein hormone subunit alpha 2)
Type: protein-coding
Summary: GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway; MF: hormone activity, protein binding, protein heterodimerization activity, thyrotropin-releasing hormone receptor binding; CC: extracellular region, extracellular space
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Hormone ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q96T91
Entrez ID: 170589
|
Does Knockout of PIK3CD in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
PIK3CD
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta)
Type: protein-coding
Summary: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010].
Gene Ontology: BP: B cell activation, B cell chemotaxis, B cell differentiation, B cell receptor signaling pathway, T cell activation, T cell chemotaxis, T cell costimulation, T cell differentiation, T cell receptor signaling pathway, adaptive immune response, cell differentiation, cell migration, cell surface receptor signaling pathway, chemotaxis, immune response, immune system process, inflammatory response, innate immune response, leukocyte mediated immunity, lipid metabolic process, mast cell chemotaxis, mast cell degranulation, mast cell differentiation, natural killer cell activation, natural killer cell chemotaxis, natural killer cell differentiation, neutrophil chemotaxis, neutrophil extravasation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, positive regulation of angiogenesis, positive regulation of cell migration, positive regulation of cytokine production, positive regulation of developmental process, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of epithelial tube formation, positive regulation of gene expression, positive regulation of multicellular organismal process, positive regulation of neutrophil apoptotic process, protein phosphorylation, regulation of anatomical structure morphogenesis, regulation of multicellular organismal development, respiratory burst involved in defense response, signal transduction, vascular endothelial growth factor signaling pathway; MF: 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, kinase activity, nucleotide binding, protein binding, transferase activity; CC: cytoplasm, cytosol, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA, plasma membrane
Pathways: 3-phosphoinositide biosynthesis, AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), AMP-activated protein kinase (AMPK) signaling, AMPK signaling pathway - Homo sapiens (human), Acute myeloid leukemia - Homo sapiens (human), Aldosterone-regulated sodium reabsorption - Homo sapiens (human), Alpha6Beta4Integrin, Alzheimer disease - Homo sapiens (human), Amoebiasis - Homo sapiens (human), Angiopoietin Like Protein 8 Regulatory Pathway, Apoptosis - Homo sapiens (human), Autophagy - animal - Homo sapiens (human), Axon guidance - Homo sapiens (human), B cell receptor signaling pathway - Homo sapiens (human), Bacterial invasion of epithelial cells - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, C-type lectin receptor signaling pathway - Homo sapiens (human), Cancer immunotherapy by CTLA4 blockade, Carbohydrate digestion and absorption - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Central carbon metabolism in cancer - Homo sapiens (human), Chagas disease - Homo sapiens (human), Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Choline metabolism in cancer - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Chronic myeloid leukemia - Homo sapiens (human), Colorectal cancer - Homo sapiens (human), Coronavirus disease - COVID-19 - Homo sapiens (human), DNA damage response (only ATM dependent), Diabetic cardiomyopathy - Homo sapiens (human), EGFR Tyrosine Kinase Inhibitor Resistance, EGFR1, ESC Pluripotency Pathways, Ebola Virus Pathway on Host, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Epithelial to mesenchymal transition in colorectal cancer, Epstein-Barr virus infection - Homo sapiens (human), ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), Estrogen signaling pathway - Homo sapiens (human), Fc epsilon RI signaling pathway - Homo sapiens (human), Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), FoxO signaling pathway - Homo sapiens (human), G13 Signaling Pathway, Gastric cancer - Homo sapiens (human), Glioblastoma signaling pathways, Glioma - Homo sapiens (human), GnRH secretion - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), HIF-1 signaling pathway - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IL-3 signaling pathway, IL-4 signaling pathway, IL2, IL3, IL4, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Influenza A - Homo sapiens (human), Inositol phosphate metabolism - Homo sapiens (human), Insulin Signaling, Insulin resistance - Homo sapiens (human), Insulin signaling pathway - Homo sapiens (human), Interferon type I signaling pathways, JAK-STAT signaling pathway - Homo sapiens (human), Joubert syndrome, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Kisspeptin-kisspeptin receptor system in the ovary, Leukocyte transendothelial migration - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Longevity regulating pathway - Homo sapiens (human), Longevity regulating pathway - multiple species - Homo sapiens (human), Measles - Homo sapiens (human), Melanoma, Melanoma - Homo sapiens (human), MicroRNAs in cancer - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, Microglia Pathogen Phagocytosis Pathway, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Neural Crest Cell Migration during Development, Neural Crest Cell Migration in Cancer, Neurotrophin signaling pathway - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), Non-alcoholic fatty liver disease - Homo sapiens (human), Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Nonalcoholic fatty liver disease, Osteoblast differentiation, Osteoclast differentiation - Homo sapiens (human), Overview of nanoparticle effects, PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Phosphatidylinositol Phosphate Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Platelet activation - Homo sapiens (human), Prion disease - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), Prolactin signaling pathway - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of lipolysis in adipocytes - Homo sapiens (human), Regulation of toll-like receptor signaling pathway, Relationship between inflammation, COX-2 and EGFR, Relaxin signaling pathway - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), Resistin as a regulator of inflammation, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Sphingolipid signaling pathway - Homo sapiens (human), Spinocerebellar ataxia - Homo sapiens (human), Synaptic signaling pathways associated with autism spectrum disorder, T cell receptor signaling pathway - Homo sapiens (human), TNF signaling pathway - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Toll-like Receptor Signaling Pathway, Toll-like receptor signaling pathway - Homo sapiens (human), Type II diabetes mellitus - Homo sapiens (human), VEGF signaling pathway - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), Yersinia infection - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human), mTOR signaling pathway - Homo sapiens (human), superpathway of inositol phosphate compounds
UniProt: O00329
Entrez ID: 5293
|
Does Knockout of DDX19A in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
DDX19A
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: DDX19A (DEAD-box helicase 19A)
Type: protein-coding
Summary: Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: poly(A)+ mRNA export from nucleus, positive regulation of apoptotic process, response to zinc ion; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding; CC: cytoplasm, cytoplasmic stress granule, membrane, nucleoplasm, nucleus
Pathways: RNA transport - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9NUU7
Entrez ID: 55308
|
Does Knockout of PCDHGB6 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
PCDHGB6
|
cell proliferation
|
Bladder Carcinoma
|
Gene: PCDHGB6 (protocadherin gamma subfamily B, 6)
Type: protein-coding
Summary: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, nervous system development; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9Y5F9
Entrez ID: 56100
|
Does Knockout of CEBPB in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
CEBPB
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CEBPB (CCAAT enhancer binding protein beta)
Type: protein-coding
Summary: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013].
Gene Ontology: BP: DNA-templated transcription, T-helper 1 cell activation, acute-phase response, brown fat cell differentiation, cell differentiation, cellular response to amino acid stimulus, cellular response to interleukin-1, cellular response to lipopolysaccharide, defense response to bacterium, embryonic placenta development, fat cell differentiation, granuloma formation, hepatocyte proliferation, immune response, inflammatory response, integrated stress response signaling, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, liver development, liver regeneration, mammary gland epithelial cell differentiation, mammary gland epithelial cell proliferation, memory, myeloid cell development, negative regulation of DNA-templated transcription, negative regulation of T cell proliferation, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, neuron differentiation, ovarian follicle development, positive regulation of DNA-templated transcription, positive regulation of biomineral tissue development, positive regulation of cold-induced thermogenesis, positive regulation of fat cell differentiation, positive regulation of gene expression, positive regulation of inflammatory response, positive regulation of interleukin-4 production, positive regulation of osteoblast differentiation, positive regulation of sodium-dependent phosphate transport, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell differentiation, regulation of dendritic cell differentiation, regulation of interleukin-6 production, regulation of odontoblast differentiation, regulation of osteoclast differentiation, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to lipopolysaccharide, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, histone acetyltransferase binding, histone deacetylase binding, identical protein binding, kinase binding, nuclear glucocorticoid receptor binding, protein binding, protein heterodimerization activity, protein homodimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, ubiquitin-like protein ligase binding; CC: C/EBP complex, CHOP-C/EBP complex, RNA polymerase II transcription regulator complex, chromatin, condensed chromosome, centromeric region, cytoplasm, nuclear matrix, nucleoplasm, nucleus
Pathways: Adipogenesis, C-MYB transcription factor network, Differentiation of white and brown adipocyte, EGFR1, Exercise-induced Circadian Regulation, FOXA1 transcription factor network, FOXA2 and FOXA3 transcription factor networks, Folate-Alcohol and Cancer Pathway Hypotheses, IFN-gamma pathway, IL-17 signaling pathway - Homo sapiens (human), IL-18 signaling pathway, IL-4 signaling pathway, IL17 signaling pathway, IL3-mediated signaling events, IL4, IL4-mediated signaling events, IL6, IL6-mediated signaling events, Lung fibrosis, Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4), NRF2-ARE regulation, Oncostatin M Signaling Pathway, Oncostatin_M, Ovarian infertility, Phytochemical activity on NRF2 transcriptional activation, Regulation of nuclear SMAD2/3 signaling, Regulation of retinoblastoma protein, Senescence and Autophagy in Cancer, Signaling mediated by p38-alpha and p38-beta, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, TCR, TNF signaling pathway - Homo sapiens (human), The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, The influence of laminopathies on Wnt signaling, Transcription factor regulation in adipogenesis, Transcriptional cascade regulating adipogenesis, Transcriptional misregulation in cancer - Homo sapiens (human), Tuberculosis - Homo sapiens (human), Validated nuclear estrogen receptor alpha network, White fat cell differentiation, il 6 signaling pathway
UniProt: P17676
Entrez ID: 1051
|
Does Knockout of DGCR6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
DGCR6
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: DGCR6 (DiGeorge syndrome critical region gene 6)
Type: protein-coding
Summary: DiGeorge syndrome, and more widely, the CATCH 22 syndrome, are associated with microdeletions in chromosomal region 22q11.2. The product of this gene shares homology with the Drosophila melanogaster gonadal protein, which participates in gonadal and germ cell development, and with the gamma-1 subunit of human laminin. This gene is a candidate for involvement in DiGeorge syndrome pathology and in schizophrenia. [provided by RefSeq, Nov 2008].
Gene Ontology: BP: animal organ morphogenesis, cell adhesion; CC: extracellular matrix, nucleus
Pathways:
UniProt: Q14129
Entrez ID: 8214
|
Does Knockout of SLC6A16 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
SLC6A16
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: SLC6A16 (solute carrier family 6 member 16)
Type: protein-coding
Summary: SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008].
Gene Ontology: BP: amino acid transport, neurotransmitter transport, sodium ion transmembrane transport; MF: neurotransmitter transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: membrane, plasma membrane
Pathways: NRF2 pathway, Nuclear Receptors Meta-Pathway
UniProt: Q9GZN6
Entrez ID: 28968
|
Does Knockout of NMD3 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
NMD3
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: NMD3 (NMD3 ribosome export adaptor)
Type: protein-coding
Summary: Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: positive regulation of RNA biosynthetic process, positive regulation of protein localization to nucleolus, protein transport, ribosomal large subunit export from nucleus; MF: RNA binding, protein-macromolecule adaptor activity, ribosomal large subunit binding; CC: cytoplasm, membrane, nucleolus, nucleoplasm, nucleus
Pathways: RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q96D46
Entrez ID: 51068
|
Does Knockout of HTR1D in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
HTR1D
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: HTR1D (5-hydroxytryptamine receptor 1D)
Type: protein-coding
Summary: Enables G protein-coupled serotonin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and intestine smooth muscle contraction. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting serotonin receptor signaling pathway, chemical synaptic transmission, intestine smooth muscle contraction, regulation of behavior, regulation of locomotion, signal transduction, smooth muscle contraction, vasoconstriction; MF: G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, Gi/o-coupled serotonin receptor activity, neurotransmitter receptor activity, serotonin receptor activity; CC: dendrite, membrane, plasma membrane, synapse
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Monoamine GPCRs, Neuroactive ligand-receptor interaction - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Serotonin receptors, Signal Transduction, Signaling by GPCR, Taste transduction - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human)
UniProt: P28221
Entrez ID: 3352
|
Does Knockout of GRAMD1A in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
GRAMD1A
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: GRAMD1A (GRAM domain containing 1A)
Type: protein-coding
Summary: Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol. Located in cytosol; organelle membrane contact site; and plasma membrane. Is extrinsic component of cytoplasmic side of plasma membrane and intrinsic component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagy, cellular response to cholesterol, intracellular sterol transport, lipid transport; MF: cholesterol binding, cholesterol transfer activity, lipid binding, protein binding; CC: autophagosome, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, membrane, organelle membrane contact site, plasma membrane
Pathways:
UniProt: Q96CP6
Entrez ID: 57655
|
Does Knockout of MIR135B in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
MIR135B
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: MIR135B (microRNA 135b)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated gene silencing by mRNA destabilization, miRNA-mediated post-transcriptional gene silencing, negative regulation of gene expression, nervous system development, positive regulation of blood vessel endothelial cell migration, positive regulation of vascular associated smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, positive regulation of vascular endothelial cell proliferation; MF: mRNA 3'-UTR binding, mRNA base-pairing post-transcriptional repressor activity
Pathways: MicroRNAs in cancer - Homo sapiens (human)
UniProt:
Entrez ID: 442891
|
Does Knockout of BUB1B in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
BUB1B
|
response to virus
|
Huh-7 Cell
|
Gene: BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B)
Type: protein-coding
Summary: This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, cell division, meiotic sister chromatid cohesion, centromeric, metaphase/anaphase transition of mitotic cell cycle, mitotic spindle assembly checkpoint signaling, protein localization to chromosome, centromeric region, regulation of sister chromatid segregation; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: anaphase-promoting complex, centrosome, chromosome, chromosome, centromeric region, ciliary basal body, cytoplasm, cytoskeleton, cytosol, kinetochore, mitotic checkpoint complex, nucleus, outer kinetochore, perinuclear region of cytoplasm, spindle
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of mitotic proteins, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Homo sapiens (human), EML4 and NUDC in mitotic spindle formation, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, PLK1 signaling events, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, Regulation of sister chromatid separation at the metaphase-anaphase transition, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O60566
Entrez ID: 701
|
Does Knockout of SDAD1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
SDAD1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SDAD1 (SDA1 domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in ribosomal large subunit biogenesis and ribosomal large subunit export from nucleus. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein transport, ribosomal large subunit biogenesis, ribosomal large subunit export from nucleus, ribosome biogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9NVU7
Entrez ID: 55153
|
Does Knockout of PSMD14 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
PSMD14
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PSMD14 (proteasome 26S subunit, non-ATPase 14)
Type: protein-coding
Summary: This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked deubiquitination, protein deubiquitination, proteolysis, regulation of proteasomal protein catabolic process, response to ethanol, ubiquitin-dependent protein catabolic process; MF: K63-linked deubiquitinase activity, endopeptidase activator activity, hydrolase activity, metal ion binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, proteasome binding, protein binding; CC: cytosol, cytosolic proteasome complex, extracellular region, ficolin-1-rich granule lumen, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, lid subcomplex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Metalloprotease DUBs, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: O00487
Entrez ID: 10213
|
Does Knockout of RFT1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
RFT1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: RFT1 (RFT1 glycolipid translocator homolog)
Type: protein-coding
Summary: This gene encodes an enzyme which catalyzes the translocation of the Man(5)GlcNAc (2)-PP-Dol intermediate from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane in the pathway for the N-glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type In.[provided by RefSeq, Dec 2008].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, glycolipid translocation, protein N-linked glycosylation; MF: glycolipid floppase activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective RFT1 causes CDG-1n, Disease, Diseases associated with N-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, Post-translational protein modification
UniProt: Q96AA3
Entrez ID: 91869
|
Does Knockout of HOXD9 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
HOXD9
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: HOXD9 (homeobox D9)
Type: protein-coding
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, adult locomotory behavior, anterior/posterior pattern specification, embryonic forelimb morphogenesis, embryonic skeletal system development, embryonic skeletal system morphogenesis, forelimb morphogenesis, hindlimb morphogenesis, mammary gland development, negative regulation of transcription by RNA polymerase II, peripheral nervous system neuron development, positive regulation of transcription by RNA polymerase II, proximal/distal pattern formation, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II, single fertilization, skeletal muscle tissue development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: P28356
Entrez ID: 3235
|
Does Knockout of MTBP in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
MTBP
|
cell proliferation
|
Melanoma Cell Line
|
Gene: MTBP (MDM2 binding protein)
Type: protein-coding
Summary: This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: negative regulation of cell population proliferation, negative regulation of mitotic nuclear division, protein localization to kinetochore, regulation of cell cycle, regulation of protein ubiquitination, traversing start control point of mitotic cell cycle; CC: chromatin, kinetochore
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Degradation of CDH1, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q96DY7
Entrez ID: 27085
|
Does Knockout of PHF5A in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
PHF5A
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PHF5A (PHD finger protein 5A)
Type: protein-coding
Summary: This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, positive regulation of DNA-templated transcription, stem cell differentiation; MF: DNA binding, RNA binding, metal ion binding, protein binding, zinc ion binding; CC: U12-type spliceosomal complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, nuclear matrix, nuclear speck, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q7RTV0
Entrez ID: 84844
|
Does Knockout of DNAH3 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
DNAH3
|
cell proliferation
|
Cancer Cell Line
|
Gene: DNAH3 (dynein axonemal heavy chain 3)
Type: protein-coding
Summary: This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016].
Gene Ontology: BP: cilium movement, cilium movement involved in cell motility, cilium-dependent cell motility, inner dynein arm assembly, microtubule-based movement; MF: ATP binding, dynein intermediate chain binding, dynein light intermediate chain binding, microtubule motor activity, minus-end-directed microtubule motor activity, nucleotide binding; CC: 9+2 motile cilium, axonemal dynein complex, cell projection, cilium, cytoplasm, cytoskeleton, dynein complex, inner dynein arm, microtubule
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), lissencephaly gene (lis1) in neuronal migration and development
UniProt: Q8TD57
Entrez ID: 55567
|
Does Knockout of SOHLH1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
SOHLH1
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: SOHLH1 (spermatogenesis and oogenesis specific basic helix-loop-helix 1)
Type: protein-coding
Summary: This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 9. Mutations in this gene are associated with nonobstructive azoospermia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: cell differentiation, oocyte differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, protein binding, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, nucleus
Pathways:
UniProt: Q5JUK2
Entrez ID: 402381
|
Does Knockout of RPL5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
RPL5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPL5 (ribosomal protein L5)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18P family of ribosomal proteins and component of the 60S subunit. The encoded protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The encoded protein may also function to inhibit tumorigenesis through the activation of downstream tumor suppressors and the downregulation of oncoprotein expression. Mutations in this gene have been identified in patients with Diamond-Blackfan Anemia (DBA). This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: cytoplasmic translation, negative regulation of protein neddylation, negative regulation of ubiquitin protein ligase activity, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of gene expression, positive regulation of translation, protein stabilization, rRNA processing, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosomal large subunit biogenesis, translation; MF: 5S rRNA binding, RNA binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, protein binding, rRNA binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, VEGFA-VEGFR2 Signaling Pathway, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, p53 pathway, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46777
Entrez ID: 6125
|
Does Knockout of PPP1R12B in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
PPP1R12B
|
cell proliferation
|
Melanoma Cell Line
|
Gene: PPP1R12B (protein phosphatase 1 regulatory subunit 12B)
Type: protein-coding
Summary: Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: neuron projection morphogenesis, regulation of muscle contraction, signal transduction; MF: enzyme activator activity, enzyme inhibitor activity, myosin phosphatase regulator activity, phosphatase regulator activity, protein binding, protein kinase binding; CC: A band, Z disc, cytoplasm, cytoskeleton, cytosol, nucleoplasm, stress fiber
Pathways: Focal Adhesion, Focal adhesion - Homo sapiens (human), Oxytocin signaling pathway - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Regulation of actin cytoskeleton - Homo sapiens (human), Vascular smooth muscle contraction - Homo sapiens (human), ccr3 signaling in eosinophils, integrin signaling pathway, pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase, rac1 cell motility signaling pathway, rho cell motility signaling pathway, thrombin signaling and protease-activated receptors
UniProt: O60237
Entrez ID: 4660
|
Does Knockout of CENPN in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
CENPN
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: CENPN (centromere protein N)
Type: protein-coding
Summary: The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: CENP-A containing chromatin assembly, chromosome segregation; CC: chromosome, chromosome, centromeric region, cytosol, inner kinetochore, kinetochore, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q96H22
Entrez ID: 55839
|
Does Knockout of NECTIN3 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
NECTIN3
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: NECTIN3 (nectin cell adhesion molecule 3)
Type: protein-coding
Summary: This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: cell adhesion, cell-cell adhesion, cochlea morphogenesis, establishment of protein localization to plasma membrane, fertilization, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, lens morphogenesis in camera-type eye, protein localization to cell junction, regulation of postsynapse assembly, retina morphogenesis in camera-type eye, symbiont entry into host cell; MF: cell adhesion mediator activity, cell adhesion molecule binding, identical protein binding, protein binding, protein homodimerization activity; CC: adherens junction, anchoring junction, apical junction complex, axon, cell-cell contact zone, cell-cell junction, dendrite, hippocampal mossy fiber to CA3 synapse, membrane, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse
Pathways: Adherens junction - Homo sapiens (human), Cell adhesion molecules - Homo sapiens (human), Nectin adhesion pathway
UniProt: Q9NQS3
Entrez ID: 25945
|
Does Knockout of REG3G in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
REG3G
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: REG3G (regenerating family member 3 gamma)
Type: protein-coding
Summary: This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: MyD88-dependent toll-like receptor signaling pathway, acute-phase response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response to Gram-positive bacterium, inflammatory response, negative regulation of keratinocyte differentiation, positive regulation of cell population proliferation, positive regulation of keratinocyte proliferation, positive regulation of wound healing, response to peptide hormone; MF: carbohydrate binding, metal ion binding, oligosaccharide binding, peptidoglycan binding, signaling receptor activity; CC: cytoplasm, extracellular region, extracellular space
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: Q6UW15
Entrez ID: 130120
|
Does Knockout of NT5M in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
NT5M
|
response to virus
|
Hepatoma Cell Line
|
Gene: NT5M (5',3'-nucleotidase, mitochondrial)
Type: protein-coding
Summary: This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, dUMP catabolic process, deoxyribonucleotide catabolic process, nucleobase-containing compound metabolic process, nucleotide metabolic process, pyrimidine deoxyribonucleotide catabolic process; MF: 5'-nucleotidase activity, hydrolase activity, metal ion binding, nucleotidase activity, nucleotide binding; CC: mitochondrial matrix, mitochondrion
Pathways: Metabolism, Metabolism of nucleotides, Nicotinate and nicotinamide metabolism - Homo sapiens (human), Nucleotide catabolism, Purine metabolism - Homo sapiens (human), Pyrimidine catabolism, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human)
UniProt: Q9NPB1
Entrez ID: 56953
|
Does Knockout of CA1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
CA1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: CA1 (carbonic anhydrase 1)
Type: protein-coding
Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016].
Gene Ontology: MF: arylesterase activity, carbonate dehydratase activity, cyanamide hydratase activity, hydro-lyase activity, lyase activity, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol, extracellular exosome
Pathways: Betazole Action Pathway, C-MYB transcription factor network, Cimetidine Action Pathway, Cytokine Signaling in Immune system, Erythrocytes take up carbon dioxide and release oxygen, Erythrocytes take up oxygen and release carbon dioxide, Esomeprazole Action Pathway, Famotidine Action Pathway, Gastric Acid Production, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Immune System, Interleukin-12 family signaling, Interleukin-12 signaling, Lansoprazole Action Pathway, Metabolism, Metiamide Action Pathway, Nitrogen metabolism - Homo sapiens (human), Nizatidine Action Pathway, O2/CO2 exchange in erythrocytes, Omeprazole Action Pathway, Pantoprazole Action Pathway, Pirenzepine Action Pathway, Rabeprazole Action Pathway, Ranitidine Action Pathway, Reversible hydration of carbon dioxide, Roxatidine acetate Action Pathway, Signaling by Interleukins, Transport of small molecules
UniProt: P00915
Entrez ID: 759
|
Does Knockout of EID3 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
EID3
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: EID3 (EP300 interacting inhibitor of differentiation 3)
Type: protein-coding
Summary: Predicted to be involved in DNA repair. Located in nucleolus and nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin looping, double-strand break repair via homologous recombination, protein sumoylation, regulation of telomere maintenance; CC: Smc5-Smc6 complex, chromosome, chromosome, telomeric region, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q8N140
Entrez ID: 493861
|
Does Knockout of RRP7A in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
RRP7A
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: RRP7A (ribosomal RNA processing 7 homolog A)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to act upstream of or within blastocyst formation. Predicted to be located in nucleoplasm. Predicted to be part of CURI complex and UTP-C complex. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: blastocyst formation, cilium disassembly, protein localization to nucleolus, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, nucleic acid binding, protein binding; CC: CURI complex, UTP-C complex, cell junction, cell projection, centrosome, cilium, cytoplasm, cytoskeleton, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y3A4
Entrez ID: 27341
|
Does Knockout of RNASEH2A in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
RNASEH2A
|
response to virus
|
Lung Cancer Cell Line
|
Gene: RNASEH2A (ribonuclease H2 subunit A)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].
Gene Ontology: BP: DNA replication, DNA replication, removal of RNA primer, RNA catabolic process, RNA metabolic process, mismatch repair; MF: RNA binding, RNA nuclease activity, RNA-DNA hybrid ribonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, protein binding; CC: cytosol, nucleoplasm, nucleus, ribonuclease H2 complex
Pathways: DNA replication - Homo sapiens (human)
UniProt: O75792
Entrez ID: 10535
|
Does Knockout of PSMA5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
PSMA5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PSMA5 (proteasome 20S subunit alpha 5)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; CC: cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: P28066
Entrez ID: 5686
|
Does Knockout of DAB2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
DAB2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DAB2 (DAB adaptor protein 2)
Type: protein-coding
Summary: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: Wnt signaling pathway, apoptotic process, cell differentiation, cellular response to epidermal growth factor stimulus, cellular response to transforming growth factor beta stimulus, clathrin coat assembly, endocytosis, integrin-mediated signaling pathway, leading edge cell differentiation, negative regulation of ERK1 and ERK2 cascade, negative regulation of androgen receptor signaling pathway, negative regulation of apoptotic process, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, negative regulation of epithelial cell proliferation, negative regulation of neuron projection development, negative regulation of protein localization to plasma membrane, negative regulation of transcription by RNA polymerase II, positive regulation of SMAD protein signal transduction, positive regulation of Wnt signaling pathway, planar cell polarity pathway, positive regulation of aldosterone biosynthetic process, positive regulation of aldosterone secretion, positive regulation of cell migration, positive regulation of clathrin-dependent endocytosis, positive regulation of early endosome to late endosome transport, positive regulation of endocytosis, positive regulation of epithelial to mesenchymal transition, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of substrate adhesion-dependent cell spreading, positive regulation of transcription by RNA polymerase II, protein transport, receptor-mediated endocytosis, response to salt, response to steroid hormone, transforming growth factor beta receptor signaling pathway; MF: SMAD binding, cargo receptor activity, clathrin adaptor activity, low-density lipoprotein particle receptor binding, protein binding; CC: clathrin-coated pit, clathrin-coated vesicle, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, fibrillar center, focal adhesion, intracellular membrane-bounded organelle, lysosomal membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, EGFR1, Endocytosis - Homo sapiens (human), Endoderm differentiation, Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, TGF-beta Signaling Pathway, TGF-beta receptor signaling, TGF_beta_Receptor, Vesicle-mediated transport
UniProt: P98082
Entrez ID: 1601
|
Does Knockout of RSPO3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
RSPO3
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: RSPO3 (R-spondin 3)
Type: protein-coding
Summary: This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: Wnt signaling pathway, angiogenesis, blood vessel remodeling, branching involved in labyrinthine layer morphogenesis, canonical Wnt signaling pathway, positive regulation of Wnt signaling pathway, positive regulation of Wnt signaling pathway, planar cell polarity pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of non-canonical Wnt signaling pathway, sprouting angiogenesis; MF: frizzled binding, heparin binding, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in WNT signaling, Regulation of FZD by ubiquitination, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Transcriptional regulation by RUNX1, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q9BXY4
Entrez ID: 84870
|
Does Knockout of CSH2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
CSH2
|
cell proliferation
|
Cancer Cell Line
|
Gene: CSH2 (chorionic somatomammotropin hormone 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: animal organ development, growth hormone receptor signaling pathway, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels; MF: growth factor activity, growth hormone receptor binding, hormone activity, metal ion binding, protein binding; CC: cytoplasm, endomembrane system, endoplasmic reticulum, extracellular region, extracellular space, vesicle
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), JAK-STAT signaling pathway - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human)
UniProt: P0DML3
Entrez ID: 1443
|
Does Knockout of BCL2L1 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
BCL2L1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: BCL2L1 (BCL2 like 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: apoptotic mitochondrial changes, apoptotic process, apoptotic process in bone marrow cell, cellular response to alkaloid, cellular response to amino acid stimulus, cellular response to gamma radiation, defense response to virus, dendritic cell apoptotic process, dendritic cell proliferation, ectopic germ cell programmed cell death, endocytosis, epithelial cell proliferation, extrinsic apoptotic signaling pathway in absence of ligand, fertilization, germ cell development, hepatocyte apoptotic process, in utero embryonic development, intrinsic apoptotic signaling pathway in response to DNA damage, male gonad development, mitochondrion organization, negative regulation of anoikis, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of dendritic cell apoptotic process, negative regulation of developmental process, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of execution phase of apoptosis, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, negative regulation of neuron apoptotic process, negative regulation of protein localization to plasma membrane, negative regulation of release of cytochrome c from mitochondria, negative regulation of reproductive process, neuron apoptotic process, ovarian follicle development, positive regulation of apoptotic process, positive regulation of mononuclear cell proliferation, regulation of apoptotic process, regulation of apoptotic signaling pathway, regulation of cytokinesis, regulation of growth, regulation of intracellular signal transduction, regulation of mitochondrial membrane permeability, regulation of mitochondrial membrane potential, release of cytochrome c from mitochondria, response to cycloheximide, response to cytokine, response to other organism, response to radiation, response to stress, response to virus, spermatogenesis, transmembrane transport; MF: BH3 domain binding, channel activity, identical protein binding, protein binding, protein kinase binding; CC: Bcl-2 family protein complex, centrosome, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endoplasmic reticulum, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, nuclear membrane, nucleus, synapse, synaptic vesicle membrane
Pathways: ATF-2 transcription factor network, Acute viral myocarditis, Amyotrophic lateral sclerosis (ALS), Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis - multiple species - Homo sapiens (human), Apoptosis Modulation and Signaling, Autophagy - animal - Homo sapiens (human), CD40/CD40L signaling, Caspase Cascade in Apoptosis, Chronic myeloid leukemia - Homo sapiens (human), Class I PI3K signaling events mediated by Akt, Direct p53 effectors, EGFR Tyrosine Kinase Inhibitor Resistance, EPO signaling pathway, ErbB1 downstream signaling, Gastrin signaling pathway, Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex, Hepatitis C and Hepatocellular Carcinoma, Hepatocellular carcinoma - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Host-pathogen interaction of human coronaviruses - apoptosis, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), IL-18 signaling pathway, IL-3 signaling pathway, IL-6 signaling pathway, IL-7 signaling pathway, IL2 signaling events mediated by PI3K, IL2 signaling events mediated by STAT5, IL3-mediated signaling events, IL4-mediated signaling events, IL6-mediated signaling events, JAK-STAT signaling pathway - Homo sapiens (human), Leptin signaling pathway, Lipid and atherosclerosis - Homo sapiens (human), LncRNA-mediated mechanisms of therapeutic resistance, Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4), Measles - Homo sapiens (human), Mitophagy - animal - Homo sapiens (human), NF-kappa B signaling pathway - Homo sapiens (human), NOD-like receptor signaling pathway - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Photodynamic therapy-induced HIF-1 survival signaling, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of apoptosis by parathyroid hormone-related protein, Role of Calcineurin-dependent NFAT signaling in lymphocytes, Shigellosis - Homo sapiens (human), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), TNF-alpha signaling pathway, TNFalpha, Toxoplasmosis - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, apoptotic signaling in response to dna damage, il-2 receptor beta chain in t cell activation, opposing roles of aif in apoptosis and cell survival, p53 signaling pathway - Homo sapiens (human), ras signaling pathway, regulation of bad phosphorylation, role of mitochondria in apoptotic signaling
UniProt: Q07817
Entrez ID: 598
|
Does Knockout of ID2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
ID2
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: ID2 (inhibitor of DNA binding 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: B cell differentiation, Peyer's patch development, adipose tissue development, adult locomotory behavior, astrocyte differentiation, bundle of His development, cell development, cell maturation, cell morphogenesis involved in neuron differentiation, cellular response to lithium ion, cellular senescence, circadian regulation of gene expression, circadian rhythm, dopaminergic neuron differentiation, embryonic digestive tract morphogenesis, endodermal digestive tract morphogenesis, entrainment of circadian clock, entrainment of circadian clock by photoperiod, enucleate erythrocyte differentiation, epithelial cell differentiation involved in mammary gland alveolus development, erythrocyte differentiation, heart development, leukocyte differentiation, locomotor rhythm, mammary gland alveolus development, mammary gland epithelial cell proliferation, membranous septum morphogenesis, metanephros development, natural killer cell differentiation, negative regulation of B cell differentiation, negative regulation of DNA-binding transcription factor activity, negative regulation of DNA-templated transcription, negative regulation of dopaminergic neuron differentiation, negative regulation of gene expression, negative regulation of muscle cell differentiation, negative regulation of oligodendrocyte differentiation, negative regulation of osteoblast differentiation, negative regulation of transcription by RNA polymerase II, neuron differentiation, neuron fate commitment, olfactory bulb development, oligodendrocyte development, oligodendrocyte differentiation, positive regulation of DNA-templated transcription, positive regulation of astrocyte differentiation, positive regulation of blood pressure, positive regulation of erythrocyte differentiation, positive regulation of fat cell differentiation, positive regulation of gene expression, positive regulation of macrophage differentiation, positive regulation of smooth muscle cell proliferation, regulation of G1/S transition of mitotic cell cycle, regulation of circadian rhythm, regulation of gene expression, regulation of lipid metabolic process, regulation of neural precursor cell proliferation, regulation of neuron differentiation, regulation of transcription by RNA polymerase II, rhythmic process, thigmotaxis, white fat cell differentiation; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, protein dimerization activity, transcription corepressor activity, transcription regulator inhibitor activity, transmembrane transporter binding; CC: cytoplasm, cytosol, euchromatin, nucleoplasm, nucleus, protein-containing complex
Pathways: Cell Differentiation - Index expanded, Development and heterogeneity of the ILC family, Development of pulmonary dendritic cells and macrophage subsets, Epithelial to mesenchymal transition in colorectal cancer, Genotoxicity pathway, HIF-1-alpha transcription factor network, Hippo signaling pathway - Homo sapiens (human), ID, ID signaling pathway, NGF-stimulated transcription, Nuclear Events (kinase and transcription factor activation), Regulation of nuclear beta catenin signaling and target gene transcription, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), TGF-beta signaling pathway - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), Validated targets of C-MYC transcriptional activation, Validated targets of C-MYC transcriptional repression, miR-517 relationship with ARCN1 and USP1
UniProt: Q02363
Entrez ID: 3398
|
Does Knockout of PRAMEF7 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
PRAMEF7
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: PRAMEF7 (PRAME family member 7)
Type: protein-coding
Summary: Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q5VXH5
Entrez ID: 441871
|
Does Knockout of NUDT21 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
NUDT21
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: NUDT21 (nudix hydrolase 21)
Type: protein-coding
Summary: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA alternative polyadenylation, mRNA processing, positive regulation of pro-B cell differentiation, positive regulation of stem cell differentiation, post-transcriptional regulation of gene expression, protein heterotetramerization, protein tetramerization; MF: RNA binding, chromatin binding, histone deacetylase binding, identical protein binding, mRNA 3'-UTR AU-rich region binding, mRNA binding, protein binding, protein homodimerization activity; CC: centriolar satellite, centrosome, cytoplasm, mRNA cleavage and polyadenylation specificity factor complex, mRNA cleavage factor complex, nuclear body, nucleoplasm, nucleus, paraspeckles
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human)
UniProt: O43809
Entrez ID: 11051
|
Does Knockout of COPG1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
COPG1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: COPG1 (coat protein complex I subunit gamma 1)
Type: protein-coding
Summary: Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of Golgi localization, intra-Golgi vesicle-mediated transport, intracellular protein transport, organelle transport along microtubule, protein secretion, protein transport, vesicle-mediated transport; MF: protein binding, structural molecule activity; CC: COPI vesicle coat, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, membrane, membrane coat, organelle membrane, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport
UniProt: Q9Y678
Entrez ID: 22820
|
Does Knockout of BANF1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
BANF1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: BANF1 (barrier to autointegration nuclear assembly factor 1)
Type: protein-coding
Summary: The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Jan 2009].
Gene Ontology: BP: DNA integration, DNA repair, cGAS/STING signaling pathway, chromatin organization, chromosome organization, mitotic nuclear membrane reassembly, negative regulation of cGAS/STING signaling pathway, negative regulation of innate immune response, negative regulation of protein ADP-ribosylation, negative regulation of type I interferon production, negative regulation of viral genome replication, positive regulation of type I interferon production, response to oxidative stress, response to virus; MF: DNA binding, double-stranded DNA binding, identical protein binding, protein binding, protein homodimerization activity; CC: chromatin, chromosome, condensed chromosome, cytoplasm, cytosol, nuclear envelope, nucleoplasm, nucleus
Pathways: 2-LTR circle formation, APOBEC3G mediated resistance to HIV-1 infection, Autointegration results in viral DNA circles, Cell Cycle, Cell Cycle, Mitotic, Disease, Early Phase of HIV Life Cycle, Envelope proteins and their potential roles in EDMD physiopathology, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, Infectious disease, Initiation of Nuclear Envelope (NE) Reformation, Integration of provirus, Integration of viral DNA into host genomic DNA, Interactions of Vpr with host cellular proteins, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Viral Infection Pathways, Vpr-mediated nuclear import of PICs
UniProt: O75531
Entrez ID: 8815
|
Does Knockout of ILK in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
ILK
|
response to virus
|
Hepatoma Cell Line
|
Gene: ILK (integrin linked kinase)
Type: protein-coding
Summary: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: Schwann cell development, anatomical structure morphogenesis, branching involved in ureteric bud morphogenesis, caveola assembly, cell differentiation, cell morphogenesis, cell population proliferation, cell projection organization, cell-matrix adhesion, establishment or maintenance of epithelial cell apical/basal polarity, fibroblast migration, integrin-mediated signaling pathway, mitotic spindle organization, myelination in peripheral nervous system, negative regulation of neural precursor cell proliferation, nerve development, neural precursor cell proliferation, outflow tract morphogenesis, phosphatidylinositol 3-kinase/protein kinase B signal transduction, platelet aggregation, positive regulation of BMP signaling pathway, positive regulation of DNA-templated transcription, positive regulation of canonical NF-kappaB signal transduction, positive regulation of canonical Wnt signaling pathway, positive regulation of cell population proliferation, positive regulation of osteoblast differentiation, positive regulation of signal transduction, positive regulation of substrate adhesion-dependent cell spreading, protein localization to cell cortex, substrate adhesion-dependent cell spreading, tumor necrosis factor-mediated signaling pathway; MF: ATP binding, integrin binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein-macromolecule adaptor activity, signaling receptor binding; CC: actin cytoskeleton, anchoring junction, cell cortex, cell projection, centrosome, chromatin, cytoplasm, cytoskeleton, cytosol, focal adhesion, lamellipodium, membrane, nucleoplasm, nucleus, plasma membrane, sarcomere
Pathways: Acute viral myocarditis, Axon guidance - Homo sapiens (human), Bacterial invasion of epithelial cells - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions, Development of ureteric collection system, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Eukaryotic Transcription Initiation, Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Focal Adhesion, Focal adhesion - Homo sapiens (human), Genes controlling nephrogenesis, Integrin-linked kinase signaling, Integrin-mediated Cell Adhesion, Integrins in angiogenesis, Localization of the PINCH-ILK-PARVIN complex to focal adhesions, Osteopontin-mediated events, PPAR signaling pathway, PPAR signaling pathway - Homo sapiens (human), Primary focal segmental glomerulosclerosis (FSGS), Shigellosis - Homo sapiens (human), Wnt, pten dependent cell cycle arrest and apoptosis
UniProt: Q13418
Entrez ID: 3611
|
Does Knockout of PLBD1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
PLBD1
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: PLBD1 (phospholipase B domain containing 1)
Type: protein-coding
Summary: Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: lipid catabolic process, lipid metabolic process, lysosomal protein catabolic process, phospholipid catabolic process; MF: aminopeptidase activity, hydrolase activity, phospholipase activity; CC: cytosol, extracellular region, extracellular space, lysosome
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Acyl chain remodelling of PI, Glycerophospholipid biosynthesis, Hydrolysis of LPC, Metabolism, Metabolism of lipids, Phospholipid metabolism
UniProt: Q6P4A8
Entrez ID: 79887
|
Does Knockout of PDPK1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
PDPK1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PDPK1 (3-phosphoinositide dependent protein kinase 1)
Type: protein-coding
Summary: Enables 3-phosphoinositide-dependent protein kinase activity; phospholipase activator activity; and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of protein kinase activity; and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection; cytosol; and plasma membrane. Implicated in prostate cancer. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: T cell costimulation, actin cytoskeleton organization, calcium-mediated signaling, cell migration, cellular response to epidermal growth factor stimulus, cellular response to insulin stimulus, epidermal growth factor receptor signaling pathway, extrinsic apoptotic signaling pathway, hyperosmotic response, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, intracellular signal transduction, intracellular signaling cassette, negative regulation of apoptotic process, negative regulation of cardiac muscle cell apoptotic process, negative regulation of endothelial cell apoptotic process, negative regulation of toll-like receptor signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to plasma membrane, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of sprouting angiogenesis, positive regulation of vascular endothelial cell proliferation, protein autophosphorylation, protein phosphorylation, regulation of canonical NF-kappaB signal transduction, regulation of endothelial cell migration, regulation of mast cell degranulation, type B pancreatic cell development, vascular endothelial cell response to laminar fluid shear stress; MF: 3-phosphoinositide-dependent protein kinase activity, ATP binding, kinase activity, nucleotide binding, phospholipase activator activity, phospholipase binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: anchoring junction, cell projection, cytoplasm, cytoplasmic vesicle, cytosol, focal adhesion, membrane, nucleus, plasma membrane, postsynaptic density
Pathways: AMPK signaling pathway - Homo sapiens (human), Aldosterone-regulated sodium reabsorption - Homo sapiens (human), Angiopoietin Like Protein 8 Regulatory Pathway, Apoptosis - Homo sapiens (human), Autophagy - animal - Homo sapiens (human), Axon guidance - Homo sapiens (human), B Cell Receptor Signaling Pathway, BCR, BCR signaling pathway, Brain-derived neurotrophic factor (BDNF) signaling pathway, CXCR3-mediated signaling events, CXCR4-mediated signaling events, Cardiac Hypertrophic Response, Choline metabolism in cancer - Homo sapiens (human), Class I PI3K signaling events, Class I PI3K signaling events mediated by Akt, EGF-EGFR signaling pathway, EGFR Tyrosine Kinase Inhibitor Resistance, EGFR1, Endometrial cancer, Endometrial cancer - Homo sapiens (human), ErbB signaling pathway, ErbB1 downstream signaling, FAS (CD95) signaling pathway, FGF signaling pathway, Fc epsilon RI signaling pathway - Homo sapiens (human), Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), FoxO signaling pathway - Homo sapiens (human), Ghrelin, Glioblastoma signaling pathways, Head and Neck Squamous Cell Carcinoma, IGF1 pathway, IL8- and CXCR1-mediated signaling events, IL8- and CXCR2-mediated signaling events, Insulin Pathway, Insulin Signaling, Insulin Signalling, Insulin resistance - Homo sapiens (human), Insulin signaling pathway - Homo sapiens (human), Integrin-mediated Cell Adhesion, Interleukin-11 Signaling Pathway, Intracellular Signalling Through Adenosine Receptor A2a and Adenosine, Intracellular Signalling Through Adenosine Receptor A2b and Adenosine, Leptin Insulin Overlap, Lipid and atherosclerosis - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, Modulators of TCR signaling and T cell activation, Neurotrophin signaling pathway - Homo sapiens (human), Non-small cell lung cancer - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PPAR signaling pathway, PPAR signaling pathway - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by Stem cell factor receptor (c-Kit), Signaling events mediated by VEGFR1 and VEGFR2, Sphingolipid signaling pathway - Homo sapiens (human), T cell receptor signaling pathway - Homo sapiens (human), T-cell receptor (TCR) signaling pathway, TCR signaling in naïve CD4+ T cells, TCR signaling in naïve CD8+ T cells, TGF-beta receptor signaling, TGF_beta_Receptor, Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid stimulating hormone (TSH) signaling pathway, Toxoplasmosis - Homo sapiens (human), Trk receptor signaling mediated by PI3K and PLC-gamma, VEGFA-VEGFR2 Signaling Pathway, VEGFR1 specific signals, actions of nitric oxide in the heart, akt signaling pathway, b cell survival pathway, control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk), corticosteroids and cardioprotection, human cytomegalovirus and map kinase pathways, il-2 receptor beta chain in t cell activation, inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages, influence of ras and rho proteins on g1 to s transition, mTOR signaling pathway, mTOR signaling pathway - Homo sapiens (human), mtor signaling pathway, nfat and hypertrophy of the heart , phosphoinositides and their downstream targets, phospholipase c signaling pathway, phospholipids as signalling intermediaries, ras signaling pathway, regulation of bad phosphorylation, regulation of eif-4e and p70s6 kinase, role of erbb2 in signal transduction and oncology, role of erk5 in neuronal survival pathway, role of nicotinic acetylcholine receptors in the regulation of apoptosis, skeletal muscle hypertrophy is regulated via akt-mtor pathway, the igf-1 receptor and longevity, transcription factor creb and its extracellular signals, trefoil factors initiate mucosal healing, trka receptor signaling pathway, vegf hypoxia and angiogenesis
UniProt: O15530
Entrez ID: 5170
|
Does Knockout of MRPL4 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
MRPL4
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: MRPL4 (mitochondrial ribosomal protein L4)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9BYD3
Entrez ID: 51073
|
Does Knockout of SPAG7 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
SPAG7
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SPAG7 (sperm associated antigen 7)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: nucleic acid binding, protein binding
Pathways:
UniProt: O75391
Entrez ID: 9552
|
Does Knockout of RPL7 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
RPL7
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: RPL7 (ribosomal protein L7)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal large subunit biogenesis, translation; MF: DNA binding, RNA binding, identical protein binding, mRNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, focal adhesion, membrane, nucleolus, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, VEGFA-VEGFR2 Signaling Pathway, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P18124
Entrez ID: 6129
|
Does Knockout of NOC4L in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
NOC4L
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: NOC4L (nucleolar complex associated 4 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: rRNA processing, ribosome biogenesis; MF: RNA binding, protein binding; CC: Noc4p-Nop14p complex, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9BVI4
Entrez ID: 79050
|
Does Knockout of CDK7 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
CDK7
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CDK7 (cyclin dependent kinase 7)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II promoter clearance, RNA polymerase II transcription initiation surveillance, cell division, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, snRNA transcription by RNA polymerase II, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription pausing by RNA polymerase II; MF: ATP binding, ATP-dependent activity, acting on DNA, RNA polymerase II CTD heptapeptide repeat S5 kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: CAK-ERCC2 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, fibrillar center, male germ cell nucleus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, transcription factor TFIIH core complex, transcription factor TFIIH holo complex, transcription factor TFIIK complex
Pathways: AndrogenReceptor, BCR, Basal transcription factors - Homo sapiens (human), Cardiac Hypertrophic Response, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA Repair, DNA Repair Pathways Full Network, Disease, Dual incision in TC-NER, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, G1 Phase, G1 to S cell cycle control, G1/S Transition, G2/M Transition, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Integrated breast cancer pathway, Late Phase of HIV Life Cycle, Metabolism of RNA, MicroRNAs in cardiomyocyte hypertrophy, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Retinoic acid receptors-mediated signaling, S Phase, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, Viral Infection Pathways, cyclins and cell cycle regulation, estrogen responsive protein efp controls cell cycle and breast tumors growth, mRNA Capping, sonic hedgehog receptor ptc1 regulates cell cycle
UniProt: P50613
Entrez ID: 1022
|
Does Knockout of TXNL4B in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
TXNL4B
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: TXNL4B (thioredoxin like 4B)
Type: protein-coding
Summary: Predicted to be involved in mRNA splicing, via spliceosome. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; CC: U4/U6 x U5 tri-snRNP complex, U5 snRNP, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways:
UniProt: Q9NX01
Entrez ID: 54957
|
Does Knockout of XRN1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
XRN1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: XRN1 (5'-3' exoribonuclease 1)
Type: protein-coding
Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: RNA metabolic process, cellular response to cycloheximide, cellular response to puromycin, histone mRNA catabolic process, negative regulation of telomere maintenance via telomerase, negative regulation of translation, nuclear mRNA surveillance, nuclear-transcribed mRNA catabolic process, rRNA catabolic process, response to testosterone; MF: 5'-3' RNA exonuclease activity, 5'-3' exonuclease activity, DNA binding, G-quadruplex DNA binding, G-quadruplex RNA binding, RNA binding, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, protein binding, telomerase RNA binding; CC: P-body, cytoplasm, cytosol, dendrite, membrane, neuronal cell body, nucleus, plasma membrane
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q8IZH2
Entrez ID: 54464
|
Does Knockout of NDUFAF7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
NDUFAF7
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: NDUFAF7 (NADH:ubiquinone oxidoreductase complex assembly factor 7)
Type: protein-coding
Summary: This gene encodes an assembly factor protein which helps in the assembly and stabilization of Complex I, a large multi-subunit enzyme in the mitochondrial respiratory chain. Complex I is involved in several physiological activities in the cell, including metabolite transport and ATP synthesis. The encoded protein is a methyltransferase which methylates Arg85 of a subunit of Complex I in the early stages of its assembly. A pseudogene related to this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: methylation, mitochondrial respiratory chain complex I assembly, peptidyl-arginine methylation, to symmetrical-dimethyl arginine; MF: enzyme binding, methyltransferase activity, protein binding, protein-arginine omega-N symmetric methyltransferase activity, transferase activity; CC: extracellular space, mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: Q7L592
Entrez ID: 55471
|
Does Knockout of USP7 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
USP7
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: USP7 (ubiquitin specific peptidase 7)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: DNA alkylation repair, DNA damage response, DNA repair, TORC1 signaling, autophagosome assembly, cellular response to nutrient levels, monoubiquitinated protein deubiquitination, negative regulation of TORC1 signaling, negative regulation of autophagy, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of gluconeogenesis, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of autophagy, protein deubiquitination, protein stabilization, protein ubiquitination, proteolysis, regulation of DNA-binding transcription factor activity, regulation of circadian rhythm, regulation of establishment of protein localization to telomere, regulation of protein stability, regulation of retrograde transport, endosome to Golgi, regulation of signal transduction by p53 class mediator, regulation of telomere capping, rhythmic process, symbiont-mediated disruption of host cell PML body, transcription-coupled nucleotide-excision repair; MF: K48-linked deubiquitinase activity, cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, p53 binding, peptidase activity, protein binding; CC: PML body, chromosome, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus, protein-containing complex
Pathways: DNA Repair, Deubiquitination, Dual incision in TC-NER, Epstein-Barr virus infection - Homo sapiens (human), Formation of TC-NER Pre-Incision Complex, FoxO family signaling, FoxO signaling pathway - Homo sapiens (human), Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, Metabolism of proteins, Nucleotide Excision Repair, PIP3 activates AKT signaling, PTEN Regulation, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Transcription, Regulation of PTEN localization, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of toll-like receptor signaling pathway, Signal Transduction, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Ub-specific processing proteases, Viral carcinogenesis - Homo sapiens (human), p53 pathway
UniProt: Q93009
Entrez ID: 7874
|
Does Knockout of PAFAH2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
PAFAH2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PAFAH2 (platelet activating factor acetylhydrolase 2)
Type: protein-coding
Summary: This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: blood coagulation, lipid catabolic process, lipid metabolic process; MF: 1-alkyl-2-acetylglycerophosphocholine esterase activity, hydrolase activity, phospholipid binding, platelet-activating factor acetyltransferase activity, transferase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Ether lipid metabolism - Homo sapiens (human), Hemostasis, Platelet homeostasis
UniProt: Q99487
Entrez ID: 5051
|
Does Knockout of AK6 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
AK6
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: AK6 (adenylate kinase 6)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: nucleobase-containing small molecule interconversion, nucleoside monophosphate phosphorylation, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: AMP kinase activity, ATP binding, ATP hydrolysis activity, kinase activity, nucleoside monophosphate kinase activity, nucleotide binding, protein binding, transferase activity; CC: Cajal body, centrosome, cytoplasm, membrane, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways: Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q9Y3D8
Entrez ID: 102157402
|
Does Knockout of NXT1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
NXT1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: NXT1 (nuclear transport factor 2 like export factor 1)
Type: protein-coding
Summary: The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA export from nucleus, mRNA export from nucleus, nucleocytoplasmic transport, poly(A)+ mRNA export from nucleus, protein export from nucleus, protein transport; MF: protein binding, small GTPase binding; CC: cytoplasm, cytosol, nuclear RNA export factor complex, nuclear pore, nuclear pore central transport channel, nuclear speck, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Influenza A - Homo sapiens (human), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9UKK6
Entrez ID: 29107
|
Does Knockout of VCP in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
VCP
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: VCP (valosin containing protein)
Type: protein-coding
Summary: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: ATP metabolic process, DNA damage response, DNA repair, ERAD pathway, NAD+ metabolic process, aggresome assembly, autophagosome maturation, autophagy, canonical NF-kappaB signal transduction, cellular response to arsenite ion, cellular response to heat, cellular response to misfolded protein, cytoplasm protein quality control, double-strand break repair, endoplasmic reticulum stress-induced pre-emptive quality control, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum unfolded protein response, endosome to lysosome transport via multivesicular body sorting pathway, establishment of protein localization, flavin adenine dinucleotide catabolic process, interstrand cross-link repair, macroautophagy, mitotic spindle disassembly, negative regulation of hippo signaling, negative regulation of protein localization to chromatin, negative regulation of smoothened signaling pathway, positive regulation of ATP biosynthetic process, positive regulation of canonical Wnt signaling pathway, positive regulation of mitochondrial membrane potential, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of oxidative phosphorylation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K63-linked deubiquitination, positive regulation of protein catabolic process, positive regulation of protein-containing complex assembly, positive regulation of ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, protein-DNA covalent cross-linking repair, regulation of aerobic respiration, regulation of apoptotic process, regulation of protein localization to chromatin, regulation of synapse organization, retrograde protein transport, ER to cytosol, stress granule disassembly, translesion synthesis, ubiquitin-dependent protein catabolic process, viral genome replication; MF: ADP binding, ATP binding, ATP hydrolysis activity, BAT3 complex binding, K48-linked polyubiquitin modification-dependent protein binding, MHC class I protein binding, RNA binding, deubiquitinase activator activity, hydrolase activity, identical protein binding, lipid binding, nucleotide binding, polyubiquitin modification-dependent protein binding, protein binding, protein domain specific binding, protein phosphatase binding, protein-containing complex binding, ubiquitin protein ligase binding, ubiquitin-like protein ligase binding, ubiquitin-modified protein reader activity, ubiquitin-specific protease binding; CC: ATPase complex, Derlin-1 retrotranslocation complex, VCP-NPL4-UFD1 AAA ATPase complex, VCP-NSFL1C complex, azurophil granule lumen, ciliary basal body, cytoplasm, cytoplasmic stress granule, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, glutamatergic synapse, intracellular membrane-bounded organelle, lipid droplet, nucleoplasm, nucleus, perinuclear region of cytoplasm, proteasome complex, protein-containing complex, secretory granule lumen, site of double-strand break, synapse
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Aggrephagy, Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, Attachment and Entry, Autophagy, Cellular response to chemical stress, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Co-inhibition by PD-1, DNA Damage Bypass, DNA Repair, Defective CFTR causes cystic fibrosis, Deubiquitination, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, E3 ubiquitin ligases ubiquitinate target proteins, Early SARS-CoV-2 Infection Events, HSF1 activation, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Immune System, Infectious disease, Innate Immune System, Josephin domain DUBs, KEAP1-NFE2L2 pathway, Legionellosis - Homo sapiens (human), Macroautophagy, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Neddylation, Neutrophil degranulation, Ovarian tumor domain proteases, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Protein methylation, Protein processing in endoplasmic reticulum - Homo sapiens (human), Protein ubiquitination, RHO GTPase cycle, RHOH GTPase cycle, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Selective autophagy, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Translation, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Transport of small molecules, Viral Infection Pathways
UniProt: P55072
Entrez ID: 7415
|
Does Knockout of LRRC37B in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
LRRC37B
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: LRRC37B (leucine rich repeat containing 37B)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q96QE4
Entrez ID: 114659
|
Does Knockout of PPP2CA in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
PPP2CA
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PPP2CA (protein phosphatase 2 catalytic subunit alpha)
Type: protein-coding
Summary: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, T cell homeostasis, intracellular signal transduction, meiotic cell cycle, mesoderm development, mitotic cell cycle, negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial to mesenchymal transition, negative regulation of glycolytic process through fructose-6-phosphate, negative regulation of hippo signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, peptidyl-threonine dephosphorylation, positive regulation of NLRP3 inflammasome complex assembly, protein dephosphorylation, regulation of G1/S transition of mitotic cell cycle, regulation of cell differentiation, regulation of growth, regulation of microtubule polymerization, regulation of transcription by RNA polymerase II, response to lead ion, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, vascular endothelial cell response to oscillatory fluid shear stress; MF: GABA receptor binding, RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein heterodimerization activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, tau protein binding; CC: FAR/SIN/STRIPAK complex, INTAC complex, chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, extracellular exosome, membrane, membrane raft, microtubule cytoskeleton, mitochondrion, nucleus, plasma membrane, protein phosphatase type 2A complex, protein serine/threonine phosphatase complex, spindle pole, synapse
Pathways: 16p11.2 proximal deletion syndrome, AMPK signaling pathway - Homo sapiens (human), ATR signaling pathway, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Association Between Physico-Chemical Features and Toxicity Associated Pathways, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), Brain-derived neurotrophic factor (BDNF) signaling pathway, C-MYC pathway, Cancer immunotherapy by CTLA4 blockade, Chagas disease - Homo sapiens (human), Dopamine metabolism, Dopaminergic synapse - Homo sapiens (human), ErbB1 downstream signaling, FGFR3 signaling in chondrocyte proliferation and terminal differentiation, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glycogen Synthesis and Degradation, Hepatitis C - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IL3, IL8- and CXCR2-mediated signaling events, Long-term depression - Homo sapiens (human), Mesodermal commitment pathway, Oocyte meiosis - Homo sapiens (human), PDGFR-beta signaling pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PLK1 signaling events, Regulation of retinoblastoma protein, Sphingolipid pathway, Sphingolipid signaling pathway - Homo sapiens (human), TGF-beta receptor signaling, TGF-beta signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, Tight junction - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, Wnt, Wnt signaling pathway and pluripotency, akt signaling pathway, mRNA surveillance pathway - Homo sapiens (human), p53 pathway, regulation of eif-4e and p70s6 kinase
UniProt: P67775
Entrez ID: 5515
|
Does Knockout of USP17L13 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
USP17L13
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: USP17L13 (ubiquitin specific peptidase 17 like family member 13)
Type: protein-coding
Summary: Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein deubiquitination, proteolysis, regulation of apoptotic process, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: cytosol, endoplasmic reticulum, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: C9JLJ4
Entrez ID: 100287238
|
Does Knockout of GALNT7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
GALNT7
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: GALNT7 (polypeptide N-acetylgalactosaminyltransferase 7)
Type: protein-coding
Summary: This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate metabolic process, protein O-linked glycosylation, protein O-linked glycosylation via N-acetyl-galactosamine, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, extracellular exosome, membrane
Pathways: Metabolism of proteins, Mucin type O-glycan biosynthesis - Homo sapiens (human), O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Homo sapiens (human), Post-translational protein modification, mucin core 1 and core 2 <i>O</i>-glycosylation
UniProt: Q86SF2
Entrez ID: 51809
|
Does Knockout of NOL7 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
NOL7
|
cell proliferation
|
Cancer Cell Line
|
Gene: NOL7 (nucleolar protein 7)
Type: protein-coding
Summary: The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: maturation of SSU-rRNA, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding; CC: chromosome, mitochondrion, nucleolus, nucleus, small-subunit processome
Pathways:
UniProt: Q9UMY1
Entrez ID: 51406
|
Does Knockout of LIX1L in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
LIX1L
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: LIX1L (limb and CNS expressed 1 like)
Type: protein-coding
Summary: Predicted to be involved in autophagosome maturation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8IVB5
Entrez ID: 128077
|
Does Knockout of MOB2 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
MOB2
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: MOB2 (MOB kinase activator 2)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to act upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding, protein kinase activator activity; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q70IA6
Entrez ID: 81532
|
Does Knockout of CENPA in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
CENPA
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: CENPA (centromere protein A)
Type: protein-coding
Summary: Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: CENP-A containing chromatin assembly, cell division, establishment of mitotic spindle orientation, kinetochore assembly, mitotic cytokinesis, protein localization to CENP-A containing chromatin, protein localization to chromosome, centromeric region; MF: DNA binding, chromatin binding, protein binding, protein heterodimerization activity, structural constituent of chromatin; CC: CENP-A containing chromatin, CENP-A containing nucleosome, chromosome, chromosome, centromeric region, condensed chromosome, centromeric region, cytosol, nucleoplasm, nucleosome, nucleus, pericentric heterochromatin
Pathways: Aurora A signaling, Aurora B signaling, FOXM1 transcription factor network
UniProt: P49450
Entrez ID: 1058
|
Does Knockout of IFI6 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
IFI6
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: IFI6 (interferon alpha inducible protein 6)
Type: protein-coding
Summary: This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, cellular response to virus, defense response to virus, immune response, immune system process, innate immune response, intrinsic apoptotic signaling pathway, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of mitochondrial depolarization, negative regulation of release of cytochrome c from mitochondria, reactive oxygen species metabolic process, regulation of epidermal growth factor receptor signaling pathway; MF: molecular adaptor activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, plasma membrane
Pathways: Cytokine Signaling in Immune system, Immune System, Interferon Signaling, Interferon alpha/beta signaling, Modulation of host responses by IFN-stimulated genes, Type II interferon signaling (IFNG)
UniProt: P09912
Entrez ID: 2537
|
Does Knockout of RGS17 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
RGS17
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: RGS17 (regulator of G protein signaling 17)
Type: protein-coding
Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, negative regulation of signal transduction, response to amphetamine; MF: GTPase activator activity, GTPase activity, protein binding; CC: cytoplasm, membrane, neuron projection, nucleus, plasma membrane, synapse
Pathways: Calcium Regulation in the Cardiac Cell, G alpha (i) signalling events, G alpha (q) signalling events, G alpha (z) signalling events, GPCR downstream signalling, Myometrial relaxation and contraction pathways, Signal Transduction, Signaling by GPCR
UniProt: Q9UGC6
Entrez ID: 26575
|
Does Knockout of FEN1 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
FEN1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: FEN1 (flap structure-specific endonuclease 1)
Type: protein-coding
Summary: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA replication, DNA replication, removal of RNA primer, UV protection, base-excision repair, base-excision repair, gap-filling, double-strand break repair, double-strand break repair via homologous recombination, memory, positive regulation of sister chromatid cohesion, telomere maintenance via semi-conservative replication; MF: 5'-3' exonuclease activity, 5'-flap endonuclease activity, DNA binding, DNA endonuclease activity, RNA-DNA hybrid ribonuclease activity, catalytic activity, damaged DNA binding, double-stranded DNA binding, double-stranded DNA exodeoxyribonuclease activity, endonuclease activity, exonuclease activity, flap endonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds, magnesium ion binding, manganese ion binding, metal ion binding, nuclease activity, protein binding; CC: chromosome, telomeric region, membrane, mitochondrion, nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways: Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Disease, Early Phase of HIV Life Cycle, Extension of Telomeres, HDR through MMEJ (alt-NHEJ), HIV Infection, HIV Life Cycle, Homology Directed Repair, Infectious disease, Lagging Strand Synthesis, Non-homologous end-joining - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, POLB-Dependent Long Patch Base Excision Repair, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Viral Infection Pathways
UniProt: P39748
Entrez ID: 2237
|
Does Knockout of ZNF45 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
ZNF45
|
cell proliferation
|
Cancer Cell Line
|
Gene: ZNF45 (zinc finger protein 45)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q02386
Entrez ID: 7596
|
Does Knockout of ATP6V0B in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
ATP6V0B
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ATP6V0B (ATPase H+ transporting V0 subunit b)
Type: protein-coding
Summary: This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
Gene Ontology: BP: Golgi lumen acidification, endosomal lumen acidification, intracellular pH reduction, lysosomal lumen acidification, monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, vacuolar acidification; MF: protein binding, proton transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism; CC: Golgi membrane, clathrin-coated vesicle membrane, cytoplasmic vesicle, endosome, endosome membrane, lysosomal membrane, membrane, phagocytic vesicle membrane, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V0 domain, proton-transporting two-sector ATPase complex, proton-transporting domain, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Homo sapiens (human), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Homo sapiens (human), Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: Q99437
Entrez ID: 533
|
Does Knockout of MAJIN in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
MAJIN
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: MAJIN (membrane anchored junction protein)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to be located in chromosome, telomeric region. Predicted to be integral component of nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: double-strand break repair involved in meiotic recombination, homologous chromosome pairing at meiosis, meiotic attachment of telomere to nuclear envelope, meiotic cell cycle, meiotic telomere clustering, oogenesis, spermatogenesis; MF: DNA binding, protein binding; CC: chromosome, chromosome, telomeric region, membrane, nuclear envelope, nuclear inner membrane, nucleus
Pathways:
UniProt: Q3KP22
Entrez ID: 283129
|
Does Knockout of UCHL5 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
UCHL5
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: UCHL5 (ubiquitin C-terminal hydrolase L5)
Type: protein-coding
Summary: Enables endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin remodeling, forebrain morphogenesis, lateral ventricle development, midbrain development, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of smoothened signaling pathway, positive regulation of telomere maintenance in response to DNA damage, protein deubiquitination, proteolysis, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, regulation of proteasomal protein catabolic process, telomere maintenance, ubiquitin-dependent protein catabolic process; MF: RNA binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, endopeptidase inhibitor activity, hydrolase activity, peptidase activity, proteasome binding, protein binding; CC: Ino80 complex, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, proteasome complex
Pathways: TGF-beta Signaling Pathway
UniProt: Q9Y5K5
Entrez ID: 51377
|
Does Knockout of BORA in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
BORA
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: BORA (BORA aurora kinase A activator)
Type: protein-coding
Summary: BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell division, regulation of mitotic nuclear division, regulation of mitotic spindle organization, regulation of protein localization; MF: protein binding, protein kinase binding; CC: cytoplasm, cytosol, meiotic spindle, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Transition, Mitotic G2-G2/M phases, PLK1 signaling events, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q6PGQ7
Entrez ID: 79866
|
Does Knockout of SLURP1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
SLURP1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SLURP1 (secreted LY6/PLAUR domain containing 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell activation, cell adhesion, locomotory behavior, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of keratinocyte proliferation, neuromuscular process controlling posture, urokinase plasminogen activator signaling pathway; MF: acetylcholine receptor activator activity, cytokine activity, protein binding; CC: extracellular exosome, extracellular region, extracellular space
Pathways: Neuroactive ligand-receptor interaction - Homo sapiens (human)
UniProt: P55000
Entrez ID: 57152
|
Does Knockout of VHL in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
VHL
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: VHL (von Hippel-Lindau tumor suppressor)
Type: protein-coding
Summary: This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [provided by RefSeq, Jun 2022].
Gene Ontology: BP: amyloid fibril formation, cell morphogenesis, cellular response to hypoxia, negative regulation of TORC1 signaling, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of macromolecule biosynthetic process, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of signal transduction, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of cell differentiation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization, protein ubiquitination, proteolysis, regulation of DNA-templated transcription, regulation of cellular response to hypoxia, regulation of gene expression, response to hypoxia; MF: DNA-binding transcription factor binding, enzyme binding, molecular adaptor activity, protein binding, protein serine/threonine kinase binding, transcription elongation factor activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activity; CC: cilium, cytoplasm, cytosol, endoplasmic reticulum, membrane, microtubule cytoskeleton, mitochondrion, nucleoplasm, nucleus, plasma membrane
Pathways: Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, HIF-1 signaling pathway - Homo sapiens (human), HIF-2-alpha transcription factor network, Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, Pathways in cancer - Homo sapiens (human), Pathways in clear cell renal cell carcinoma, Renal cell carcinoma - Homo sapiens (human), Type 2 papillary renal cell carcinoma, Ubiquitin mediated proteolysis - Homo sapiens (human), hypoxia-inducible factor in the cardivascular system, vegf hypoxia and angiogenesis
UniProt: P40337
Entrez ID: 7428
|
Does Knockout of VEZT in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
VEZT
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: VEZT (vezatin, adherens junctions transmembrane protein)
Type: protein-coding
Summary: This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011].
Gene Ontology: BP: cell-cell adhesion; CC: acrosomal vesicle, adherens junction, anchoring junction, cell projection, cytoplasmic vesicle, cytosol, membrane, nucleoplasm, nucleus, plasma membrane, stereocilia ankle link complex, stereocilium membrane
Pathways:
UniProt: Q9HBM0
Entrez ID: 55591
|
Does Knockout of PSMD8 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
PSMD8
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: PSMD8 (proteasome 26S subunit, non-ATPase 8)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis; CC: cytosol, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex, protein-containing complex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P48556
Entrez ID: 5714
|
Does Knockout of WDR43 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
WDR43
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: WDR43 (WD repeat domain 43)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, rRNA processing, regulation of DNA-templated transcription, regulation of stem cell population maintenance, regulation of transcription elongation by RNA polymerase II, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, RNA polymerase II complex binding, protein binding, transcription elongation factor activity; CC: chromatin, fibrillar center, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q15061
Entrez ID: 23160
|
Does Knockout of EIF2B3 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
EIF2B3
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)
Type: protein-coding
Summary: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: T cell receptor signaling pathway, central nervous system development, cytoplasmic translational initiation, oligodendrocyte development, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, protein binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Translation, Translation Factors
UniProt: Q9NR50
Entrez ID: 8891
|
Does Knockout of MED21 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
MED21
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: MED21 (mediator complex subunit 21)
Type: protein-coding
Summary: This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, blastocyst development, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance; MF: DNA-directed RNA polymerase activity, protein binding, transcription coactivator activity, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Infectious disease, Metabolism, Metabolism of lipids, PPARA activates gene expression, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q13503
Entrez ID: 9412
|
Does Knockout of MYBPC1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
MYBPC1
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: MYBPC1 (myosin binding protein C1)
Type: protein-coding
Summary: This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: cell adhesion, sarcomere organization; MF: actin binding, myosin binding, protein binding, structural constituent of muscle, titin binding; CC: M band, cytosol, myofibril, myosin filament
Pathways: Muscle contraction, Striated Muscle Contraction, Striated Muscle Contraction Pathway
UniProt: Q00872
Entrez ID: 4604
|
Does Knockout of TUBGCP5 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
TUBGCP5
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TUBGCP5 (tubulin gamma complex component 5)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, spindle assembly; MF: gamma-tubulin binding, microtubule binding, microtubule minus-end binding, protein binding; CC: centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, gamma-tubulin complex, gamma-tubulin ring complex, microtubule, microtubule organizing center, spindle pole
Pathways: 15q11.2 copy number variation syndrome, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Prader-Willi and Angelman Syndrome, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes
UniProt: Q96RT8
Entrez ID: 114791
|
Does Knockout of EMD in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
EMD
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: EMD (emerin)
Type: protein-coding
Summary: Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: amyloid fibril formation, cellular response to growth factor stimulus, muscle contraction, muscle organ development, negative regulation of canonical Wnt signaling pathway, negative regulation of fibroblast proliferation, nuclear membrane organization, positive regulation of protein export from nucleus, regulation of canonical Wnt signaling pathway, skeletal muscle cell differentiation; MF: actin binding, beta-tubulin binding, cadherin binding, protein binding; CC: TMEM240-body, cortical endoplasmic reticulum, cytoplasm, cytosol, endoplasmic reticulum, membrane, microtubule, nuclear envelope, nuclear inner membrane, nuclear membrane, nuclear outer membrane, nucleoplasm, nucleus, spindle, spindle pole centrosome
Pathways: Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Depolymerization of the Nuclear Lamina, Dilated cardiomyopathy - Homo sapiens (human), Envelope proteins and their potential roles in EDMD physiopathology, Hypertrophic cardiomyopathy - Homo sapiens (human), Initiation of Nuclear Envelope (NE) Reformation, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Protein localization, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOD GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The influence of laminopathies on Wnt signaling
UniProt: P50402
Entrez ID: 2010
|
Does Knockout of C11orf16 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
C11orf16
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: C11orf16 (chromosome 11 open reading frame 16)
Type: protein-coding
Summary: chromosome 11 open reading frame 16
Gene Ontology:
Pathways:
UniProt: Q9NQ32
Entrez ID: 56673
|
Does Knockout of MAST3 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
MAST3
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: MAST3 (microtubule associated serine/threonine kinase 3)
Type: protein-coding
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization; intracellular signal transduction; and peptidyl-serine phosphorylation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoskeleton organization, intracellular signal transduction; MF: ATP binding, kinase activity, magnesium ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, microtubule cytoskeleton
Pathways:
UniProt: O60307
Entrez ID: 23031
|
Does Knockout of ADGRL3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
ADGRL3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ADGRL3 (adhesion G protein-coupled receptor L3)
Type: protein-coding
Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell adhesion, cell surface receptor signaling pathway, cell-cell adhesion via plasma-membrane adhesion molecules, excitatory synapse assembly, neuron migration, signal transduction, synapse assembly; MF: G protein-coupled receptor activity, calcium ion binding, carbohydrate binding, cell adhesion mediator activity, metal ion binding, molecular condensate scaffold activity, protein binding, transmembrane signaling receptor activity; CC: anchoring junction, axon, cell projection, cell-cell junction, glutamatergic synapse, membrane, plasma membrane, postsynaptic membrane, synapse
Pathways: GPCRs, Class B Secretin-like, GPCRs, Other
UniProt: Q9HAR2
Entrez ID: 23284
|
Does Knockout of PRCC in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
PRCC
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: PRCC (proline rich mitotic checkpoint control factor)
Type: protein-coding
Summary: This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010].
Gene Ontology: CC: nuclear speck, nucleoplasm, nucleus
Pathways: IL-18 signaling pathway, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Renal cell carcinoma - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), Type 2 papillary renal cell carcinoma, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q92733
Entrez ID: 5546
|
Does Knockout of KCTD9 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
KCTD9
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: KCTD9 (potassium channel tetramerization domain containing 9)
Type: protein-coding
Summary: Enables cullin family protein binding activity; identical protein binding activity; and protein self-association. Predicted to be involved in intracellular signal transduction; protein homooligomerization; and protein ubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intracellular signal transduction, protein homooligomerization, protein ubiquitination; MF: cullin family protein binding, identical protein binding, protein binding
Pathways:
UniProt: Q7L273
Entrez ID: 54793
|
Does Knockout of MCOLN2 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
MCOLN2
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: MCOLN2 (mucolipin TRP cation channel 2)
Type: protein-coding
Summary: Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009].
Gene Ontology: BP: adaptive immune response, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, immune system process, innate immune response, iron ion transmembrane transport, macrophage migration, monoatomic ion transmembrane transport, monoatomic ion transport, neutrophil migration, positive regulation of chemokine (C-C motif) ligand 5 production, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of chemokine production, positive regulation of macrophage inflammatory protein 1 alpha production, positive regulation of monocyte chemotactic protein-1 production, protein transport, regulation of chemokine (C-X-C motif) ligand 2 production; MF: NAADP-sensitive calcium-release channel activity, calcium channel activity, identical protein binding, iron ion transmembrane transporter activity, monoatomic cation channel activity; CC: endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, plasma membrane, recycling endosome, recycling endosome membrane
Pathways: Calcium signaling pathway - Homo sapiens (human), Ion channel transport, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q8IZK6
Entrez ID: 255231
|
Does Knockout of GLRX5 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
GLRX5
|
response to virus
|
Huh-7 Cell
|
Gene: GLRX5 (glutaredoxin 5)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010].
Gene Ontology: BP: [2Fe-2S] cluster assembly, cell redox homeostasis, hemopoiesis, intracellular iron ion homeostasis, iron-sulfur cluster assembly, protein maturation; MF: 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding, protein binding; CC: dendrite, iron-sulfur cluster assembly complex, mitochondrial matrix, mitochondrion, neuronal cell body
Pathways: Metabolism, Mitochondrial iron-sulfur cluster biogenesis
UniProt: Q86SX6
Entrez ID: 51218
|
Does Knockout of ASGR1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
ASGR1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ASGR1 (asialoglycoprotein receptor 1)
Type: protein-coding
Summary: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: endocytosis, immune response, receptor-mediated endocytosis; MF: D-mannose binding, asialoglycoprotein receptor activity, carbohydrate binding, fucose binding, identical protein binding, metal ion binding, pattern recognition receptor activity, protein binding; CC: external side of plasma membrane, extracellular region, membrane, plasma membrane
Pathways: Asparagine N-linked glycosylation, Ebola Virus Pathway on Host, Metabolism of proteins, Post-translational protein modification, Thyroid hormone synthesis - Homo sapiens (human)
UniProt: P07306
Entrez ID: 432
|
Does Knockout of L3MBTL4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
L3MBTL4
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: L3MBTL4 (L3MBTL histone methyl-lysine binding protein 4)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of macromolecule metabolic process, regulation of primary metabolic process; MF: chromatin binding, histone binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8NA19
Entrez ID: 91133
|
Does Knockout of ASPA in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
ASPA
|
response to virus
|
Hepatoma Cell Line
|
Gene: ASPA (aspartoacylase)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: acetate metabolic process, aspartate metabolic process; MF: aspartoacylase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, hydrolase activity, acting on ester bonds, identical protein binding, metal ion binding, protein binding; CC: cytoplasm, cytosol, nucleus
Pathways: Alanine and aspartate metabolism, Alanine, aspartate and glutamate metabolism - Homo sapiens (human), Aspartate Metabolism, Aspartate and asparagine metabolism, Canavan Disease, Histidine metabolism - Homo sapiens (human), Hypoacetylaspartia, Metabolism, Metabolism of amino acids and derivatives
UniProt: P45381
Entrez ID: 443
|
Does Knockout of CILP in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
CILP
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CILP (cartilage intermediate layer protein)
Type: protein-coding
Summary: Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: negative regulation of SMAD protein signal transduction, negative regulation of gene expression, negative regulation of insulin-like growth factor receptor signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway; MF: alkaline phosphatase activity, dinucleotide phosphatase activity, extracellular matrix structural constituent; CC: extracellular exosome, extracellular matrix, extracellular region, extracellular space
Pathways: Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: O75339
Entrez ID: 8483
|
Does Knockout of MAP10 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
MAP10
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: MAP10 (microtubule associated protein 10)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in microtubule cytoskeleton organization; positive regulation of cytokinesis; and regulation of microtubule-based process. Located in microtubule cytoskeleton and midbody. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, cytoplasmic microtubule organization, microtubule cytoskeleton organization, mitotic spindle midzone assembly, positive regulation of cytokinesis, regulation of microtubule-based process; MF: microtubule binding; CC: centrosome, cytoplasm, cytoplasmic microtubule, cytoskeleton, midbody, mitotic spindle midzone, mitotic spindle pole, spindle pole
Pathways:
UniProt: Q9P2G4
Entrez ID: 54627
|
Does Knockout of KRTAP19-6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
KRTAP19-6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: KRTAP19-6 (keratin associated protein 19-6)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: Q3LI70
Entrez ID: 337973
|
Does Knockout of TP53I3 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
TP53I3
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TP53I3 (tumor protein p53 inducible protein 3)
Type: protein-coding
Summary: The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
Gene Ontology: MF: NADPH binding, oxidoreductase activity, protein homodimerization activity, quinone binding, quinone reductase (NADPH) activity
Pathways: Direct p53 effectors, Gene expression (Transcription), Generic Transcription Pathway, Genotoxicity pathway, RNA Polymerase II Transcription, SARS-CoV-2 innate immunity evasion and cell-specific immune response, TP53 Regulates Transcription of Cell Death Genes, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, Transcriptional Regulation by TP53, Validated transcriptional targets of TAp63 isoforms, p53 signaling pathway - Homo sapiens (human), p53 transcriptional gene network, p73 transcription factor network
UniProt: Q53FA7
Entrez ID: 9540
|
Does Knockout of MRPL27 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
MRPL27
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: MRPL27 (mitochondrial ribosomal protein L27)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9P0M9
Entrez ID: 51264
|
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