prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of TMEM97 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | TMEM97 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: TMEM97 (transmembrane protein 97)
Type: protein-coding
Summary: TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009].
Gene Ontology: BP: cholesterol homeostasis, pos... |
Does Knockout of TUSC1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | TUSC1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: TUSC1 (tumor suppressor candidate 1)
Type: protein-coding
Summary: This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell l... |
Does Knockout of ZNF418 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | ZNF418 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: ZNF418 (zinc finger protein 418)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Activation of GPHA2 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | GPHA2 | response to virus | Hepatoma Cell Line | Gene: GPHA2 (glycoprotein hormone subunit alpha 2)
Type: protein-coding
Summary: GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: adenylate cyclase-activatin... |
Does Knockout of PIK3CD in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | PIK3CD | cell proliferation | acute lymphoblastic leukemia cell line | Gene: PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta)
Type: protein-coding
Summary: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. ... |
Does Knockout of DDX19A in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | DDX19A | cell proliferation | Medulloblastoma Cell Line | Gene: DDX19A (DEAD-box helicase 19A)
Type: protein-coding
Summary: Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: poly... |
Does Knockout of PCDHGB6 in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | PCDHGB6 | cell proliferation | Bladder Carcinoma | Gene: PCDHGB6 (protocadherin gamma subfamily B, 6)
Type: protein-coding
Summary: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanis... |
Does Knockout of CEBPB in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | CEBPB | cell proliferation | Endometrial Cancer Cell Line | Gene: CEBPB (CCAAT enhancer binding protein beta)
Type: protein-coding
Summary: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, ... |
Does Knockout of DGCR6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | DGCR6 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: DGCR6 (DiGeorge syndrome critical region gene 6)
Type: protein-coding
Summary: DiGeorge syndrome, and more widely, the CATCH 22 syndrome, are associated with microdeletions in chromosomal region 22q11.2. The product of this gene shares homology with the Drosophila melanogaster gonadal protein, whi... |
Does Knockout of SLC6A16 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | SLC6A16 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: SLC6A16 (solute carrier family 6 member 16)
Type: protein-coding
Summary: SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multipl... |
Does Knockout of NMD3 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | NMD3 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: NMD3 (NMD3 ribosome export adaptor)
Type: protein-coding
Summary: Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Sev... |
Does Knockout of HTR1D in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | HTR1D | cell proliferation | Glioblastoma Cell Line | Gene: HTR1D (5-hydroxytryptamine receptor 1D)
Type: protein-coding
Summary: Enables G protein-coupled serotonin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and intestine smooth muscle contraction. Is integral component of plasma membrane. [pro... |
Does Knockout of GRAMD1A in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | GRAMD1A | cell proliferation | Ewing's Sarcoma Cell Line | Gene: GRAMD1A (GRAM domain containing 1A)
Type: protein-coding
Summary: Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol. Located in cytosol; organelle membrane contact site; and plasma membrane. Is extrinsic... |
Does Knockout of MIR135B in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | MIR135B | response to chemicals | Monocytic Leukemia Cell Line | Gene: MIR135B (microRNA 135b)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of BUB1B in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | BUB1B | response to virus | Huh-7 Cell | Gene: BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B)
Type: protein-coding
Summary: This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), dela... |
Does Knockout of SDAD1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | SDAD1 | cell proliferation | Medulloblastoma Cell Line | Gene: SDAD1 (SDA1 domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in ribosomal large subunit biogenesis and ribosomal large subunit export from nucleus. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in nucleolus and nucleoplas... |
Does Knockout of PSMD14 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | PSMD14 | cell proliferation | Gastric Cancer Cell Line | Gene: PSMD14 (proteasome 26S subunit, non-ATPase 14)
Type: protein-coding
Summary: This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S... |
Does Knockout of RFT1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | RFT1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: RFT1 (RFT1 glycolipid translocator homolog)
Type: protein-coding
Summary: This gene encodes an enzyme which catalyzes the translocation of the Man(5)GlcNAc (2)-PP-Dol intermediate from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane in the pathway for the N-glycosylation ... |
Does Knockout of HOXD9 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | HOXD9 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: HOXD9 (homeobox D9)
Type: protein-coding
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene ... |
Does Knockout of MTBP in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | MTBP | cell proliferation | Melanoma Cell Line | Gene: MTBP (MDM2 binding protein)
Type: protein-coding
Summary: This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012].
Gene On... |
Does Knockout of PHF5A in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | PHF5A | cell proliferation | Endometrial Cancer Cell Line | Gene: PHF5A (PHD finger protein 5A)
Type: protein-coding
Summary: This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a co... |
Does Knockout of DNAH3 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | DNAH3 | cell proliferation | Cancer Cell Line | Gene: DNAH3 (dynein axonemal heavy chain 3)
Type: protein-coding
Summary: This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which ... |
Does Knockout of SOHLH1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | SOHLH1 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: SOHLH1 (spermatogenesis and oogenesis specific basic helix-loop-helix 1)
Type: protein-coding
Summary: This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 9. Mutations in this gen... |
Does Knockout of RPL5 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | RPL5 | cell proliferation | Colonic Cancer Cell Line | Gene: RPL5 (ribosomal protein L5)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encod... |
Does Knockout of PPP1R12B in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | PPP1R12B | cell proliferation | Melanoma Cell Line | Gene: PPP1R12B (protein phosphatase 1 regulatory subunit 12B)
Type: protein-coding
Summary: Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) ... |
Does Knockout of CENPN in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | CENPN | cell proliferation | Medulloblastoma Cell Line | Gene: CENPN (centromere protein N)
Type: protein-coding
Summary: The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of thi... |
Does Knockout of NECTIN3 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | NECTIN3 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: NECTIN3 (nectin cell adhesion molecule 3)
Type: protein-coding
Summary: This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding... |
Does Knockout of REG3G in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | REG3G | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: REG3G (regenerating family member 3 gamma)
Type: protein-coding
Summary: This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded b... |
Does Knockout of NT5M in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | NT5M | response to virus | Hepatoma Cell Line | Gene: NT5M (5',3'-nucleotidase, mitochondrial)
Type: protein-coding
Summary: This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis... |
Does Knockout of CA1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | CA1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: CA1 (carbonic anhydrase 1)
Type: protein-coding
Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bon... |
Does Knockout of EID3 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | EID3 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: EID3 (EP300 interacting inhibitor of differentiation 3)
Type: protein-coding
Summary: Predicted to be involved in DNA repair. Located in nucleolus and nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA r... |
Does Knockout of RRP7A in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | RRP7A | cell proliferation | Neuroblastoma Cell Line | Gene: RRP7A (ribosomal RNA processing 7 homolog A)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to act upstream of or within blastocyst formation. Predicted to be located in nucleoplasm. Predicted ... |
Does Knockout of RNASEH2A in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | RNASEH2A | response to virus | Lung Cancer Cell Line | Gene: RNASEH2A (ribonuclease H2 subunit A)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotide... |
Does Knockout of PSMA5 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | PSMA5 | cell proliferation | Colonic Cancer Cell Line | Gene: PSMA5 (proteasome 20S subunit alpha 5)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 ri... |
Does Knockout of DAB2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | DAB2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: DAB2 (DAB adaptor protein 2)
Type: protein-coding
Summary: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to ... |
Does Knockout of RSPO3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | RSPO3 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: RSPO3 (R-spondin 3)
Type: protein-coding
Summary: This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development,... |
Does Knockout of CSH2 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | CSH2 | cell proliferation | Cancer Cell Line | Gene: CSH2 (chorionic somatomammotropin hormone 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four o... |
Does Knockout of BCL2L1 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | BCL2L1 | cell proliferation | T-lymphoma cell line | Gene: BCL2L1 (BCL2 like 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by ... |
Does Knockout of ID2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | ID2 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: ID2 (inhibitor of DNA binding 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA bindi... |
Does Knockout of PRAMEF7 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | PRAMEF7 | cell proliferation | Renal Cancer Cell Line | Gene: PRAMEF7 (PRAME family member 7)
Type: protein-coding
Summary: Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in ... |
Does Knockout of NUDT21 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | NUDT21 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: NUDT21 (nudix hydrolase 21)
Type: protein-coding
Summary: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end process... |
Does Knockout of COPG1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | COPG1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: COPG1 (coat protein complex I subunit gamma 1)
Type: protein-coding
Summary: Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Located i... |
Does Knockout of BANF1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | BANF1 | cell proliferation | Bladder Carcinoma | Gene: BANF1 (barrier to autointegration nuclear assembly factor 1)
Type: protein-coding
Summary: The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The pr... |
Does Knockout of ILK in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | ILK | response to virus | Hepatoma Cell Line | Gene: ILK (integrin linked kinase)
Type: protein-coding
Summary: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transductio... |
Does Knockout of PLBD1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | PLBD1 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: PLBD1 (phospholipase B domain containing 1)
Type: protein-coding
Summary: Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: lipid c... |
Does Knockout of PDPK1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | PDPK1 | cell proliferation | Gastric Cancer Cell Line | Gene: PDPK1 (3-phosphoinositide dependent protein kinase 1)
Type: protein-coding
Summary: Enables 3-phosphoinositide-dependent protein kinase activity; phospholipase activator activity; and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; ... |
Does Knockout of MRPL4 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | MRPL4 | cell proliferation | Renal Cancer Cell Line | Gene: MRPL4 (mitochondrial ribosomal protein L4)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. T... |
Does Knockout of SPAG7 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | SPAG7 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: SPAG7 (sperm associated antigen 7)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: nucleic acid binding, protein binding
Pathways:
... |
Does Knockout of RPL7 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | RPL7 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: RPL7 (ribosomal protein L7)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ... |
Does Knockout of NOC4L in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | NOC4L | cell proliferation | Medulloblastoma Cell Line | Gene: NOC4L (nucleolar complex associated 4 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: rRNA processing, ribosome b... |
Does Knockout of CDK7 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | CDK7 | cell proliferation | Endometrial Cancer Cell Line | Gene: CDK7 (cyclin dependent kinase 7)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are... |
Does Knockout of TXNL4B in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | TXNL4B | cell proliferation | Mammary Gland Tumor Cell Line | Gene: TXNL4B (thioredoxin like 4B)
Type: protein-coding
Summary: Predicted to be involved in mRNA splicing, via spliceosome. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome;... |
Does Knockout of XRN1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | XRN1 | cell proliferation | Endometrial Cancer Cell Line | Gene: XRN1 (5'-3' exoribonuclease 1)
Type: protein-coding
Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA ... |
Does Knockout of NDUFAF7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | NDUFAF7 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: NDUFAF7 (NADH:ubiquinone oxidoreductase complex assembly factor 7)
Type: protein-coding
Summary: This gene encodes an assembly factor protein which helps in the assembly and stabilization of Complex I, a large multi-subunit enzyme in the mitochondrial respiratory chain. Complex I is involved in se... |
Does Knockout of USP7 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | USP7 | cell proliferation | Endometrial Cancer Cell Line | Gene: USP7 (ubiquitin specific peptidase 7)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal p... |
Does Knockout of PAFAH2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | PAFAH2 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PAFAH2 (platelet activating factor acetylhydrolase 2)
Type: protein-coding
Summary: This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (ident... |
Does Knockout of AK6 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | AK6 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: AK6 (adenylate kinase 6)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regu... |
Does Knockout of NXT1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | NXT1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: NXT1 (nuclear transport factor 2 like export factor 1)
Type: protein-coding
Summary: The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear prot... |
Does Knockout of VCP in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | VCP | cell proliferation | Gastric Cancer Cell Line | Gene: VCP (valosin containing protein)
Type: protein-coding
Summary: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF... |
Does Knockout of LRRC37B in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | LRRC37B | cell proliferation | Multiple Myeloma Cell Line | Gene: LRRC37B (leucine rich repeat containing 37B)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q96QE4
Entrez ID: 114659 |
Does Knockout of PPP2CA in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | PPP2CA | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: PPP2CA (protein phosphatase 2 catalytic subunit alpha)
Type: protein-coding
Summary: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists o... |
Does Knockout of USP17L13 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | USP17L13 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: USP17L13 (ubiquitin specific peptidase 17 like family member 13)
Type: protein-coding
Summary: Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be loca... |
Does Knockout of GALNT7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | GALNT7 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: GALNT7 (polypeptide N-acetylgalactosaminyltransferase 7)
Type: protein-coding
Summary: This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acet... |
Does Knockout of NOL7 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | NOL7 | cell proliferation | Cancer Cell Line | Gene: NOL7 (nucleolar protein 7)
Type: protein-coding
Summary: The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene r... |
Does Knockout of LIX1L in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | LIX1L | response to chemicals | Glioblastoma Cell Line | Gene: LIX1L (limb and CNS expressed 1 like)
Type: protein-coding
Summary: Predicted to be involved in autophagosome maturation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8IVB5
Entrez I... |
Does Knockout of MOB2 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | MOB2 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: MOB2 (MOB kinase activator 2)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to act upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in c... |
Does Knockout of CENPA in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | CENPA | cell proliferation | Mammary Gland Tumor Cell Line | Gene: CENPA (centromere protein A)
Type: protein-coding
Summary: Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the c... |
Does Knockout of IFI6 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | IFI6 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: IFI6 (interferon alpha inducible protein 6)
Type: protein-coding
Summary: This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repea... |
Does Knockout of RGS17 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | RGS17 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: RGS17 (regulator of G protein signaling 17)
Type: protein-coding
Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activi... |
Does Knockout of FEN1 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | FEN1 | cell proliferation | Breast Cancer Cell Line | Gene: FEN1 (flap structure-specific endonuclease 1)
Type: protein-coding
Summary: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclea... |
Does Knockout of ZNF45 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | ZNF45 | cell proliferation | Cancer Cell Line | Gene: ZNF45 (zinc finger protein 45)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA ... |
Does Knockout of ATP6V0B in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | ATP6V0B | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ATP6V0B (ATPase H+ transporting V0 subunit b)
Type: protein-coding
Summary: This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied pro... |
Does Knockout of MAJIN in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | MAJIN | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: MAJIN (membrane anchored junction protein)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to be located in chromosome, telomeric region. P... |
Does Knockout of UCHL5 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | UCHL5 | cell proliferation | Colorectal Cancer Cell Line | Gene: UCHL5 (ubiquitin C-terminal hydrolase L5)
Type: protein-coding
Summary: Enables endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of sm... |
Does Knockout of BORA in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | BORA | cell proliferation | Colonic Cancer Cell Line | Gene: BORA (BORA aurora kinase A activator)
Type: protein-coding
Summary: BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[... |
Does Knockout of SLURP1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | SLURP1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SLURP1 (secreted LY6/PLAUR domain containing 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associ... |
Does Knockout of VHL in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | VHL | cell proliferation | Monocytic Leukemia Cell Line | Gene: VHL (von Hippel-Lindau tumor suppressor)
Type: protein-coding
Summary: This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in th... |
Does Knockout of VEZT in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | VEZT | cell proliferation | Monocytic Leukemia Cell Line | Gene: VEZT (vezatin, adherens junctions transmembrane protein)
Type: protein-coding
Summary: This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that express... |
Does Knockout of PSMD8 in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | PSMD8 | cell proliferation | Prostate Cancer Cell Line | Gene: PSMD8 (proteasome 26S subunit, non-ATPase 8)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings ar... |
Does Knockout of WDR43 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 1 | 1,996 | Knockout | WDR43 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: WDR43 (WD repeat domain 43)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Gene O... |
Does Knockout of EIF2B3 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | EIF2B3 | cell proliferation | Gastric Cancer Cell Line | Gene: EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)
Type: protein-coding
Summary: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function ... |
Does Knockout of MED21 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | MED21 | cell proliferation | Ovarian Cancer Cell Line | Gene: MED21 (mediator complex subunit 21)
Type: protein-coding
Summary: This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A ... |
Does Knockout of MYBPC1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | MYBPC1 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: MYBPC1 (myosin binding protein C1)
Type: protein-coding
Summary: This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded pr... |
Does Knockout of TUBGCP5 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | TUBGCP5 | cell proliferation | Monocytic Leukemia Cell Line | Gene: TUBGCP5 (tubulin gamma complex component 5)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: B... |
Does Knockout of EMD in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | EMD | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: EMD (emerin)
Type: protein-coding
Summary: Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting f... |
Does Knockout of C11orf16 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | C11orf16 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: C11orf16 (chromosome 11 open reading frame 16)
Type: protein-coding
Summary: chromosome 11 open reading frame 16
Gene Ontology:
Pathways:
UniProt: Q9NQ32
Entrez ID: 56673 |
Does Knockout of MAST3 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | MAST3 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: MAST3 (microtubule associated serine/threonine kinase 3)
Type: protein-coding
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization; intracellular signal transduction; and peptidyl-serine phosphorylation. [provided by Alliance ... |
Does Knockout of ADGRL3 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | ADGRL3 | cell proliferation | Colonic Cancer Cell Line | Gene: ADGRL3 (adhesion G protein-coupled receptor L3)
Type: protein-coding
Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous pr... |
Does Knockout of PRCC in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | PRCC | response to chemicals | Monocytic Leukemia Cell Line | Gene: PRCC (proline rich mitotic checkpoint control factor)
Type: protein-coding
Summary: This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal ce... |
Does Knockout of KCTD9 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | KCTD9 | cell proliferation | Colonic Cancer Cell Line | Gene: KCTD9 (potassium channel tetramerization domain containing 9)
Type: protein-coding
Summary: Enables cullin family protein binding activity; identical protein binding activity; and protein self-association. Predicted to be involved in intracellular signal transduction; protein homooligomerization; ... |
Does Knockout of MCOLN2 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | MCOLN2 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: MCOLN2 (mucolipin TRP cation channel 2)
Type: protein-coding
Summary: Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), ... |
Does Knockout of GLRX5 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | GLRX5 | response to virus | Huh-7 Cell | Gene: GLRX5 (glutaredoxin 5)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessiv... |
Does Knockout of ASGR1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | ASGR1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: ASGR1 (asialoglycoprotein receptor 1)
Type: protein-coding
Summary: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycop... |
Does Knockout of L3MBTL4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | L3MBTL4 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: L3MBTL4 (L3MBTL histone methyl-lysine binding protein 4)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Allia... |
Does Knockout of ASPA in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | ASPA | response to virus | Hepatoma Cell Line | Gene: ASPA (aspartoacylase)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA... |
Does Knockout of CILP in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | CILP | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: CILP (cartilage intermediate layer protein)
Type: protein-coding
Summary: Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarth... |
Does Knockout of MAP10 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | MAP10 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: MAP10 (microtubule associated protein 10)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in microtubule cytoskeleton organization; positive regulation of cytokinesis; and regulation of microtubule-based process. Located in microtubule cytoskeleton and midbody. [provid... |
Does Knockout of KRTAP19-6 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | KRTAP19-6 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: KRTAP19-6 (keratin associated protein 19-6)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: Q... |
Does Knockout of TP53I3 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | TP53I3 | cell proliferation | Gastric Cancer Cell Line | Gene: TP53I3 (tumor protein p53 inducible protein 3)
Type: protein-coding
Summary: The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be... |
Does Knockout of MRPL27 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | MRPL27 | cell proliferation | Medulloblastoma Cell Line | Gene: MRPL27 (mitochondrial ribosomal protein L27)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
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