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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of WASF1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
WASF1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: WASF1 (WASP family member 1)
Type: protein-coding
Summary: The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Rac protein signal transduction, actin cytoskeleton organization, actin filament polymerization, cellular response to brain-derived neurotrophic factor stimulus, dendrite extension, dendritic transport of mitochondrion, lamellipodium morphogenesis, mitochondrion organization, modification of postsynaptic actin cytoskeleton, neuron projection development, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of neurotrophin TRK receptor signaling pathway, protein-containing complex assembly, receptor-mediated endocytosis; MF: Arp2/3 complex binding, actin binding, protein binding, protein kinase A binding, protein kinase A regulatory subunit binding, small GTPase binding; CC: SCAR complex, actin cytoskeleton, anchoring junction, cytoplasm, cytoskeleton, cytosol, dendrite cytoplasm, focal adhesion, lamellipodium, mitochondrial outer membrane, mitochondrion, postsynapse, protein-containing complex, synapse
Pathways: Adherens junction - Homo sapiens (human), Bacterial invasion of epithelial cells - Homo sapiens (human), Choline metabolism in cancer - Homo sapiens (human), Disease, E2F transcription factor network, FCGR3A-mediated phagocytosis, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania phagocytosis, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), RAC1 GTPase cycle, RAC1 signaling pathway, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway, VEGFA-VEGFR2 Signaling Pathway, how does salmonella hijack a cell, rac1 cell motility signaling pathway
UniProt: Q92558
Entrez ID: 8936
|
Does Knockout of CACNA1H in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
CACNA1H
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: CACNA1H (calcium voltage-gated channel subunit alpha1 H)
Type: protein-coding
Summary: This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq, Jul 2008].
Gene Ontology: BP: aldosterone biosynthetic process, calcium ion import, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, cellular response to hormone stimulus, cellular response to potassium ion, cortisol biosynthetic process, inorganic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, muscle contraction, muscle organ development, myoblast fusion, positive regulation of acrosome reaction, regulation of heart contraction, regulation of membrane potential, transmembrane transport; MF: calcium channel activity, high voltage-gated calcium channel activity, low voltage-gated calcium channel activity, metal ion binding, monoatomic ion channel activity, protein binding, scaffold protein binding, voltage-gated calcium channel activity, voltage-gated monoatomic ion channel activity; CC: membrane, monoatomic ion channel complex, plasma membrane, voltage-gated calcium channel complex
Pathways: Acebutolol Action Pathway, Aldosterone synthesis and secretion - Homo sapiens (human), Alprenolol Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Axon guidance, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupranolol Action Pathway, Calcium signaling pathway - Homo sapiens (human), Carteolol Action Pathway, Carvedilol Action Pathway, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Circadian entrainment - Homo sapiens (human), Corticotropin-releasing hormone signaling pathway, Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Developmental Biology, Diltiazem Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Epinephrine Action Pathway, Esmolol Action Pathway, Felodipine Action Pathway, Flecainide Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, GnRH secretion - Homo sapiens (human), Ibutilide Action Pathway, Isoprenaline Action Pathway, Isradipine Action Pathway, Labetalol Action Pathway, Levobunolol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mechanical load activates signaling by PIEZO1 and integrins in osteocytes, Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Muscle contraction, Muscle/Heart Contraction, NCAM signaling for neurite out-growth, NCAM1 interactions, Nadolol Action Pathway, Nebivolol Action Pathway, Nervous system development, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Penbutolol Action Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Practolol Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Smooth Muscle Contraction, Sotalol Action Pathway, Timolol Action Pathway, Tocainide Action Pathway, Verapamil Action Pathway
UniProt: O95180
Entrez ID: 8912
|
Does Knockout of SRSF2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
SRSF2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SRSF2 (serine and arginine rich splicing factor 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: RNA splicing, mRNA processing, negative regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding, transcription corepressor activity; CC: PML body, cytosol, nuclear speck, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, spliceosomal assembly
UniProt: Q01130
Entrez ID: 6427
|
Does Knockout of RAPGEF2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
RAPGEF2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Type: protein-coding
Summary: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, MAPK cascade, Rap protein signal transduction, Ras protein signal transduction, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, blood vessel development, brain-derived neurotrophic factor receptor signaling pathway, cAMP-mediated signaling, cell differentiation, cellular response to cAMP, cellular response to cGMP, cellular response to nerve growth factor stimulus, establishment of endothelial barrier, establishment of endothelial intestinal barrier, forebrain neuron development, intracellular signal transduction, microvillus assembly, negative regulation of cell population proliferation, negative regulation of dendrite morphogenesis, negative regulation of melanin biosynthetic process, nerve growth factor signaling pathway, nervous system development, neuron migration, neuron projection development, neuropeptide signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of GTPase activity, positive regulation of cAMP-dependent protein kinase activity, positive regulation of dendritic cell apoptotic process, positive regulation of microvillus assembly, positive regulation of neuron migration, positive regulation of neuron projection development, positive regulation of protein binding, positive regulation of protein kinase activity, positive regulation of vasculogenesis, protein localization to plasma membrane, regulation of cell junction assembly, regulation of neuron projection development, regulation of synaptic plasticity, signal transduction, small GTPase-mediated signal transduction, ventricular system development; MF: GTPase activator activity, PDZ domain binding, WW domain binding, beta-1 adrenergic receptor binding, cAMP binding, cGMP binding, calcium ion binding, diacylglycerol binding, guanyl-nucleotide exchange factor activity, phosphatidic acid binding, protein binding; CC: anchoring junction, apical plasma membrane, bicellular tight junction, cell-cell junction, cytoplasm, cytosol, endocytic vesicle, endosome, late endosome, membrane, neuron projection, neuronal cell body, perinuclear region of cytoplasm, plasma membrane, protein-containing complex, synapse
Pathways: Genotoxicity pathway, Intracellular Signalling Through Adenosine Receptor A2a and Adenosine, Intracellular Signalling Through Adenosine Receptor A2b and Adenosine, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Rap1 signaling pathway - Homo sapiens (human), Signal Transduction, Tight junction - Homo sapiens (human)
UniProt: Q9Y4G8
Entrez ID: 9693
|
Does Knockout of PCP4L1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
PCP4L1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PCP4L1 (Purkinje cell protein 4 like 1)
Type: protein-coding
Summary: Purkinje cell protein 4 like 1
Gene Ontology:
Pathways:
UniProt: A6NKN8
Entrez ID: 654790
|
Does Knockout of TRAPPC3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
TRAPPC3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TRAPPC3 (trafficking protein particle complex subunit 3)
Type: protein-coding
Summary: This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: COPII vesicle coating, Golgi vesicle transport, endoplasmic reticulum to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, Golgi membrane, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, cis-Golgi network membrane, cytoplasm, cytosol, endoplasmic reticulum
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O43617
Entrez ID: 27095
|
Does Knockout of MCC in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
MCC
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: MCC (MCC regulator of Wnt signaling pathway)
Type: protein-coding
Summary: This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Wnt signaling pathway, establishment of protein localization, negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial cell migration, negative regulation of epithelial cell proliferation, signal transduction; MF: protein binding, signaling receptor activity; CC: cell projection, cytoplasm, cytosol, lamellipodium, membrane, nucleoplasm, nucleus, plasma membrane
Pathways: TNFalpha
UniProt: P23508
Entrez ID: 4163
|
Does Knockout of OSBPL11 in Prostate Cancer Cell Line causally result in response to chemicals?
| 1
| 2,109
|
Knockout
|
OSBPL11
|
response to chemicals
|
Prostate Cancer Cell Line
|
Gene: OSBPL11 (oxysterol binding protein like 11)
Type: protein-coding
Summary: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: fat cell differentiation, lipid transport, triglyceride homeostasis; MF: lipid binding, protein binding, sterol binding; CC: Golgi apparatus, cytosol, endosome, late endosome membrane, membrane, nucleoplasm
Pathways: RHO GTPase cycle, RHOH GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9BXB4
Entrez ID: 114885
|
Does Knockout of SLC38A9 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
SLC38A9
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SLC38A9 (solute carrier family 38 member 9)
Type: protein-coding
Summary: Enables L-arginine transmembrane transporter activity and L-leucine transmembrane transporter activity. Involved in amino acid transmembrane transport; cellular response to amino acid stimulus; and positive regulation of TOR signaling. Located in late endosome and lysosomal membrane. Is integral component of lysosomal membrane. Colocalizes with Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: L-arginine transmembrane transport, amino acid transmembrane transport, amino acid transport, asparagine transport, branched-chain amino acid transport, cellular response to amino acid stimulus, glutamine transport, positive regulation of TOR signaling, positive regulation of TORC1 signaling; MF: L-amino acid transmembrane transporter activity, L-arginine transmembrane transporter activity, L-asparagine transmembrane transporter activity, L-glutamine transmembrane transporter activity, L-leucine transmembrane transporter activity, amino acid transmembrane transporter activity, arginine binding, cholesterol binding, guanyl-nucleotide exchange factor activity, metal ion binding, protein binding, sterol sensor activity; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane
Pathways: Amino acids regulate mTORC1, Autophagy, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Homo sapiens (human), mTORC1-mediated signalling
UniProt: Q8NBW4
Entrez ID: 153129
|
Does Knockout of KTI12 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
KTI12
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: KTI12 (KTI12 chromatin associated homolog)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: ATP binding, nucleotide binding, protein binding
Pathways:
UniProt: Q96EK9
Entrez ID: 112970
|
Does Activation of EDN1 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
EDN1
|
protein/peptide accumulation
|
T cell
|
Gene: EDN1 (endothelin 1)
Type: protein-coding
Summary: This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: ERK1 and ERK2 cascade, G protein-coupled receptor signaling pathway, MAPK cascade, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, artery smooth muscle contraction, axon extension, axon guidance, axonogenesis involved in innervation, blood vessel diameter maintenance, blood vessel morphogenesis, body fluid secretion, branching involved in blood vessel morphogenesis, cAMP/PKA signal transduction, calcium ion transmembrane transport, calcium-mediated signaling, canonical Wnt signaling pathway, cardiac neural crest cell migration involved in outflow tract morphogenesis, cartilage development, cell surface receptor signaling pathway, cell-cell signaling, cellular response to calcium ion, cellular response to fatty acid, cellular response to follicle-stimulating hormone stimulus, cellular response to glucocorticoid stimulus, cellular response to human chorionic gonadotropin stimulus, cellular response to hydrogen peroxide, cellular response to hypoxia, cellular response to interleukin-1, cellular response to luteinizing hormone stimulus, cellular response to mineralocorticoid stimulus, cellular response to peptide hormone stimulus, cellular response to toxic substance, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, cellular response to type II interferon, cellular response to xenobiotic stimulus, dorsal/ventral pattern formation, embryonic heart tube development, endothelin receptor signaling pathway, endothelin receptor signaling pathway involved in heart process, epithelial fluid transport, gene expression, glomerular endothelium development, glomerular filtration, heart development, heart process, histamine secretion, in utero embryonic development, intracellular calcium ion homeostasis, intracellular signal transduction, leukocyte activation, maternal process involved in parturition, meiotic cell cycle process involved in oocyte maturation, membrane depolarization, middle ear morphogenesis, mitochondrion organization, negative regulation of blood coagulation, negative regulation of gene expression, negative regulation of hormone secretion, negative regulation of phospholipase C/protein kinase C signal transduction, negative regulation of protein metabolic process, negative regulation of smooth muscle cell apoptotic process, negative regulation of transcription by RNA polymerase II, neural crest cell development, neural crest cell differentiation, neural crest cell fate commitment, neuron projection development, neutrophil chemotaxis, nitric oxide transport, noradrenergic neuron differentiation, peptide hormone secretion, pharyngeal arch artery morphogenesis, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phospholipase C-activating G protein-coupled receptor signaling pathway, phospholipase D-activating G protein-coupled receptor signaling pathway, podocyte differentiation, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of artery morphogenesis, positive regulation of calcium-mediated signaling, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cardiac muscle hypertrophy, positive regulation of cation channel activity, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cell size, positive regulation of chemokine-mediated signaling pathway, positive regulation of cytosolic calcium ion concentration, positive regulation of endothelial cell migration, positive regulation of heart rate, positive regulation of hormone secretion, positive regulation of mitotic nuclear division, positive regulation of neutrophil chemotaxis, positive regulation of nitric oxide biosynthetic process, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of odontogenesis, positive regulation of prostaglandin biosynthetic process, positive regulation of prostaglandin secretion, positive regulation of protein localization to nucleus, positive regulation of renal sodium excretion, positive regulation of sarcomere organization, positive regulation of smooth muscle cell proliferation, positive regulation of smooth muscle contraction, positive regulation of transcription by RNA polymerase II, positive regulation of urine volume, positive regulation of vascular associated smooth muscle cell proliferation, regulation of D-glucose transmembrane transport, regulation of blood pressure, regulation of pH, regulation of systemic arterial blood pressure by endothelin, regulation of vasoconstriction, renal sodium ion absorption, respiratory gaseous exchange by respiratory system, response to activity, response to amino acid, response to amphetamine, response to dexamethasone, response to hypoxia, response to leptin, response to lipopolysaccharide, response to muscle stretch, response to nicotine, response to ozone, response to prostaglandin F, response to salt, response to testosterone, response to transforming growth factor beta, response to xenobiotic stimulus, rhythmic excitation, semaphorin-plexin signaling pathway involved in axon guidance, signal transduction involved in regulation of gene expression, skeletal system development, smooth muscle contraction, superoxide anion generation, sympathetic neuron axon guidance, thyroid gland development, transcription by RNA polymerase II, vasoconstriction, vein smooth muscle contraction; MF: cytokine activity, endothelin A receptor binding, endothelin B receptor binding, hormone activity, protein binding, receptor ligand activity, signaling receptor binding; CC: Weibel-Palade body, basal part of cell, cytoplasm, extracellular region, extracellular space, rough endoplasmic reticulum lumen, transport vesicle
Pathways: -arrestins in gpcr desensitization, AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), AP-1 transcription factor network, Class A/1 (Rhodopsin-like receptors), Developmental Biology, EGFR-dependent Endothelin signaling events, Endothelin Pathways, Endothelins, Fluid shear stress and atherosclerosis - Homo sapiens (human), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, HIF-1 signaling pathway - Homo sapiens (human), HIF-1-alpha transcription factor network, Hypertrophic cardiomyopathy - Homo sapiens (human), Lung fibrosis, MITF-M-regulated melanocyte development, Melanogenesis - Homo sapiens (human), Melatonin metabolism and effects, MicroRNAs in cardiomyocyte hypertrophy, Neuroactive ligand-receptor interaction - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Peptide ligand-binding receptors, Photodynamic therapy-induced HIF-1 survival signaling, Physiological and pathological hypertrophy of the heart, Prostaglandin Synthesis and Regulation, Relaxin signaling pathway - Homo sapiens (human), Renin secretion - Homo sapiens (human), Signal Transduction, Signaling by GPCR, TNF signaling pathway - Homo sapiens (human), Transcriptional and post-translational regulation of MITF-M expression and activity, Vascular smooth muscle contraction - Homo sapiens (human), activation of camp-dependent protein kinase pka, activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor, activation of pkc through g-protein coupled receptors, cAMP signaling pathway - Homo sapiens (human), chrebp regulation by carbohydrates and camp, corticosteroids and cardioprotection, cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway, g-protein signaling through tubby proteins, hypoxia-inducible factor in the cardivascular system, ion channels and their functional role in vascular endothelium, nfat and hypertrophy of the heart , role of -arrestins in the activation and targeting of map kinases, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, roles of arrestin dependent recruitment of src kinases in gpcr signaling
UniProt: P05305
Entrez ID: 1906
|
Does Knockout of RNF4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
RNF4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RNF4 (ring finger protein 4)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010].
Gene Ontology: BP: DNA damage response, negative regulation of protein localization to chromatin, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein K6-linked ubiquitination, protein K63-linked ubiquitination, protein autoubiquitination, protein ubiquitination, regulation of kinetochore assembly, regulation of spindle assembly, response to arsenic-containing substance; MF: DNA binding, SUMO polymer binding, identical protein binding, metal ion binding, nucleosome binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: PML body, cytoplasm, microtubule end, nuclear body, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Androgen receptor signaling pathway, AndrogenReceptor, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Immune System, Processing of DNA double-strand break ends
UniProt: P78317
Entrez ID: 6047
|
Does Knockout of KCTD20 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
KCTD20
|
cell proliferation
|
Cancer Cell Line
|
Gene: KCTD20 (potassium channel tetramerization domain containing 20)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of phosphorylation. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of phosphorylation; CC: cytoplasm
Pathways:
UniProt: Q7Z5Y7
Entrez ID: 222658
|
Does Knockout of LGALS12 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
LGALS12
|
response to chemicals
|
Melanoma Cell Line
|
Gene: LGALS12 (galectin 12)
Type: protein-coding
Summary: This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010].
Gene Ontology: BP: apoptotic process, intrinsic apoptotic signaling pathway; MF: carbohydrate binding, lactose binding; CC: cytoplasm, mitochondrion, nucleus
Pathways:
UniProt: Q96DT0
Entrez ID: 85329
|
Does Knockout of INTS13 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
INTS13
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: INTS13 (integrator complex subunit 13)
Type: protein-coding
Summary: Involved in regulation of mitotic cell cycle. Acts upstream of or within centrosome localization; mitotic spindle organization; and protein localization to nuclear envelope. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, cell division, centrosome localization, flagellated sperm motility, mitotic spindle organization, protein localization to nuclear envelope, regulation of fertilization, regulation of mitotic cell cycle, regulation of transcription elongation by RNA polymerase II, snRNA processing; MF: DNA-binding transcription factor binding, protein binding; CC: INTAC complex, cytoplasm, integrator complex, nuclear body, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q9NVM9
Entrez ID: 55726
|
Does Knockout of RPS29 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
RPS29
|
cell proliferation
|
T-lymphoma cell line
|
Gene: RPS29 (ribosomal protein S29)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: cytoplasmic translation, translation; MF: metal ion binding, structural constituent of ribosome, zinc ion binding; CC: cytoplasm, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, extracellular exosome, focal adhesion, nucleoplasm, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, small ribosomal subunit
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62273
Entrez ID: 6235
|
Does Knockout of CACNA1G in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
CACNA1G
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: CACNA1G (calcium voltage-gated channel subunit alpha1 G)
Type: protein-coding
Summary: Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: AV node cell action potential, AV node cell to bundle of His cell signaling, SA node cell action potential, SA node cell to atrial cardiac muscle cell signaling, action potential, calcium ion import, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, cardiac muscle cell action potential involved in contraction, chemical synaptic transmission, membrane depolarization during AV node cell action potential, membrane depolarization during SA node cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of atrial cardiac muscle cell membrane depolarization, regulation of biological quality, regulation of heart rate, regulation of heart rate by cardiac conduction, regulation of membrane potential, response to nickel cation, sinoatrial node development, transmembrane transport; MF: calcium channel activity, high voltage-gated calcium channel activity, low voltage-gated calcium channel activity, monoatomic ion channel activity, scaffold protein binding, voltage-gated calcium channel activity, voltage-gated calcium channel activity involved SA node cell action potential, voltage-gated calcium channel activity involved in AV node cell action potential; CC: cytoplasm, membrane, monoatomic ion channel complex, plasma membrane, synapse, voltage-gated calcium channel complex
Pathways: Acebutolol Action Pathway, Aldosterone synthesis and secretion - Homo sapiens (human), Alprenolol Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Axon guidance, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupranolol Action Pathway, Calcium signaling pathway - Homo sapiens (human), Carteolol Action Pathway, Carvedilol Action Pathway, Circadian entrainment - Homo sapiens (human), Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Developmental Biology, Diltiazem Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Epinephrine Action Pathway, Esmolol Action Pathway, Felodipine Action Pathway, Flecainide Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, GnRH secretion - Homo sapiens (human), Ibutilide Action Pathway, Isoprenaline Action Pathway, Isradipine Action Pathway, Labetalol Action Pathway, Levobunolol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Muscle contraction, Muscle/Heart Contraction, NCAM signaling for neurite out-growth, NCAM1 interactions, Nadolol Action Pathway, Nebivolol Action Pathway, Nervous system development, Nicotine Activity on Chromaffin Cells, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Penbutolol Action Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Practolol Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Regulation of nuclear beta catenin signaling and target gene transcription, Smooth Muscle Contraction, Sotalol Action Pathway, Timolol Action Pathway, Tocainide Action Pathway, Type II diabetes mellitus - Homo sapiens (human), Verapamil Action Pathway
UniProt: O43497
Entrez ID: 8913
|
Does Knockout of CCT6A in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
CCT6A
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CCT6A (chaperonin containing TCP1 subunit 6A)
Type: protein-coding
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: positive regulation of establishment of protein localization to telomere, positive regulation of protein localization to Cajal body, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, RNA binding, WD40-repeat domain binding, hydrolase activity, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: chaperonin-containing T-complex, cytoplasm, cytosol, extracellular exosome, microtubule
Pathways: 16p11.2 proximal deletion syndrome, Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Folding of actin by CCT/TriC, Formation of tubulin folding intermediates by CCT/TriC, Metabolism of proteins, Prefoldin mediated transfer of substrate to CCT/TriC, Protein folding, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P40227
Entrez ID: 908
|
Does Inhibition of ZFPM2 in Mammary Epithelial Cell Line causally result in cell proliferation?
| 0
| 2,248
|
Inhibition
|
ZFPM2
|
cell proliferation
|
Mammary Epithelial Cell Line
|
Gene: ZFPM2 (zinc finger protein, FOG family member 2)
Type: protein-coding
Summary: The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cardiac muscle tissue development, cardiac muscle tissue morphogenesis, cell differentiation, embryonic organ development, fat cell differentiation, gonadal mesoderm development, heart development, in utero embryonic development, lung development, negative regulation of DNA-templated transcription, negative regulation of fat cell differentiation, negative regulation of female gonad development, negative regulation of transcription by RNA polymerase II, outflow tract morphogenesis, outflow tract septum morphogenesis, positive regulation of DNA-templated transcription, positive regulation of cardiac muscle cell proliferation, positive regulation of male gonad development, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, right ventricular cardiac muscle tissue morphogenesis, vasculogenesis, ventricular septum morphogenesis; MF: DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, metal ion binding, protein binding, transcription coactivator activity, transcription corepressor activity, zinc ion binding; CC: chromatin, cytoplasm, male germ cell nucleus, nucleoplasm, nucleus
Pathways: Developmental Biology, Factors involved in megakaryocyte development and platelet production, Hemostasis, MicroRNAs in cancer - Homo sapiens (human), Transcriptional regulation of testis differentiation
UniProt: Q8WW38
Entrez ID: 23414
|
Does Knockout of CARNS1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
CARNS1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CARNS1 (carnosine synthase 1)
Type: protein-coding
Summary: CARNS1 (EC 6.3.2.11), a member of the ATP-grasp family of ATPases, catalyzes the formation of carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine), which are found mainly in skeletal muscle and the central nervous system, respectively (Drozak et al., 2010 [PubMed 20097752]).[supplied by OMIM, Apr 2010].
Gene Ontology: BP: L-histidine catabolic process, carnosine biosynthetic process; MF: ATP binding, ATP hydrolysis activity, carnosine synthase activity, homocarnosine synthase activity, ligase activity, metal ion binding, nucleotide binding
Pathways: Arginine and proline metabolism - Homo sapiens (human), Histidine Metabolism, Histidine catabolism, Histidine metabolism - Homo sapiens (human), Histidinemia, Metabolism, Metabolism of amino acids and derivatives, beta-Alanine metabolism - Homo sapiens (human), carnosine biosynthesis, homocarnosine biosynthesis
UniProt: A5YM72
Entrez ID: 57571
|
Does Knockout of HYOU1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
HYOU1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: HYOU1 (hypoxia up-regulated 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: cellular response to hypoxia, endoplasmic reticulum to Golgi vesicle-mediated transport, negative regulation of apoptotic process, negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway, protein folding, regulation of cellular response to stress, response to endoplasmic reticulum stress, response to ischemia, response to stress; MF: ATP binding, ATP-dependent protein folding chaperone, adenyl-nucleotide exchange factor activity, nucleotide binding, protein binding, protein-folding chaperone binding, unfolded protein binding; CC: endocytic vesicle lumen, endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, extracellular exosome, extracellular region, focal adhesion, membrane, mitochondrion, smooth endoplasmic reticulum
Pathways: Acetaminophen Metabolism Pathway, Binding and Uptake of Ligands by Scavenger Receptors, Cellular responses to stimuli, Cellular responses to stress, Etoposide Action Pathway, Etoposide Metabolism Pathway, IRE1alpha activates chaperones, Ibuprofen Action Pathway, Ibuprofen Metabolism Pathway, Irinotecan Action Pathway, Irinotecan Metabolism Pathway, Morphine Action Pathway, Morphine Metabolism Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Protein processing in endoplasmic reticulum - Homo sapiens (human), Retinol Metabolism, Scavenging by Class F Receptors, Sorafenib Metabolism Pathway, Unfolded Protein Response (UPR), VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport, Vitamin A Deficiency, XBP1(S) activates chaperone genes
UniProt: Q9Y4L1
Entrez ID: 10525
|
Does Knockout of SMIM10 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
SMIM10
|
response to virus
|
Hepatoma Cell Line
|
Gene: SMIM10 (small integral membrane protein 10)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q96HG1
Entrez ID: 644538
|
Does Knockout of RPA3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
RPA3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPA3 (replication protein A3)
Type: protein-coding
Summary: Enables damaged DNA binding activity and single-stranded DNA binding activity. Involved in DNA repair and DNA replication. Part of DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA replication, base-excision repair, double-strand break repair via homologous recombination, mismatch repair, nucleotide-excision repair, regulation of cell population proliferation, regulation of mitotic cell cycle, telomere maintenance; MF: DNA binding, damaged DNA binding, protein binding, single-stranded DNA binding; CC: DNA replication factor A complex, nucleoplasm, nucleus, site of double-strand break
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA strand elongation, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Fanconi Anemia Pathway, Fanconi anemia pathway - Homo sapiens (human), Formation of Incision Complex in GG-NER, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), HSF1 activation, Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to RAD51, Lagging Strand Synthesis, Meiosis, Meiotic recombination, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Homo sapiens (human), Mitotic G1 phase and G1/S transition, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of HSF1-mediated heat shock response, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Reproduction, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P35244
Entrez ID: 6119
|
Does Knockout of SPRY4 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
SPRY4
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SPRY4 (sprouty RTK signaling antagonist 4)
Type: protein-coding
Summary: This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014].
Gene Ontology: BP: animal organ development, cellular response to leukemia inhibitory factor, negative regulation of ERK1 and ERK2 cascade, negative regulation of Ras protein signal transduction, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of substrate adhesion-dependent cell spreading, regulation of signal transduction; MF: protein binding, protein kinase inhibitor activity; CC: cell projection, cytoplasm, cytosol, focal adhesion, membrane, plasma membrane, ruffle membrane
Pathways: EGFR1, sprouty regulation of tyrosine kinase signals
UniProt: Q9C004
Entrez ID: 81848
|
Does Knockout of OAF in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
OAF
|
response to chemicals
|
Melanoma Cell Line
|
Gene: OAF (out at first homolog)
Type: protein-coding
Summary: out at first homolog
Gene Ontology:
Pathways:
UniProt: Q86UD1
Entrez ID: 220323
|
Does Knockout of ARPP19 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
ARPP19
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ARPP19 (cAMP regulated phosphoprotein 19)
Type: protein-coding
Summary: The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, cell division, mitotic cell cycle, positive regulation of D-glucose import, positive regulation of gluconeogenesis; MF: phosphatase inhibitor activity, potassium channel regulator activity, protein binding, protein phosphatase 2A binding, protein phosphatase inhibitor activity, protein phosphatase regulator activity, signaling receptor binding; CC: cytoplasm, nucleoplasm
Pathways: Cell Cycle, Cell Cycle, Mitotic, M Phase, MASTL Facilitates Mitotic Progression, Mitotic Prophase
UniProt: P56211
Entrez ID: 10776
|
Does Knockout of ZNF671 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
ZNF671
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ZNF671 (zinc finger protein 671)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q8TAW3
Entrez ID: 79891
|
Does Knockout of HERC6 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
HERC6
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: HERC6 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 6)
Type: protein-coding
Summary: HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: hematopoietic progenitor cell differentiation, protein ubiquitination, response to bacterium, ubiquitin-dependent protein catabolic process; MF: transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q8IVU3
Entrez ID: 55008
|
Does Knockout of FAM234A in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
FAM234A
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: FAM234A (family with sequence similarity 234 member A)
Type: protein-coding
Summary: Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell surface, extracellular exosome, membrane
Pathways:
UniProt: Q9H0X4
Entrez ID: 83986
|
Does Knockout of MAP4K1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
MAP4K1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1)
Type: protein-coding
Summary: Enables ATP binding activity and MAP kinase kinase kinase kinase activity. Involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: JNK cascade, cell population proliferation, cellular response to phorbol 13-acetate 12-myristate, intracellular signal transduction, peptidyl-serine phosphorylation, positive regulation of MAPK cascade, protein autophosphorylation, protein phosphorylation; MF: ATP binding, MAP kinase kinase kinase kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, membrane
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, B Cell Receptor Signaling Pathway, BCR signaling pathway, Cardiac Hypertrophic Response, EGF-EGFR signaling pathway, Hippo-Yap signaling pathway, Insulin Signaling, JNK signaling in the CD4+ TCR pathway, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Modulators of TCR signaling and T cell activation, Signaling events mediated by Stem cell factor receptor (c-Kit), Signaling of Hepatocyte Growth Factor Receptor, T-cell receptor (TCR) signaling pathway, TCR, TCR signaling in naïve CD4+ T cells, TGF-beta Signaling Pathway, TGF_beta_Receptor, mapkinase signaling pathway
UniProt: Q92918
Entrez ID: 11184
|
Does Knockout of DNAJC7 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
DNAJC7
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7)
Type: protein-coding
Summary: This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: protein folding, regulation of cellular response to heat; MF: ATPase activator activity, heat shock protein binding, protein binding; CC: cytoplasm, cytoskeleton, cytosol, extracellular exosome, membrane, nucleoplasm, nucleus
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Constitutive Androstane Receptor Pathway, Nuclear Receptors Meta-Pathway, Pregnane X receptor pathway, Regulation of HSF1-mediated heat shock response
UniProt: Q99615
Entrez ID: 7266
|
Does Knockout of DCAF15 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
DCAF15
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DCAF15 (DDB1 and CUL4 associated factor 15)
Type: protein-coding
Summary: Enables small molecule binding activity. Involved in protein polyubiquitination and regulation of natural killer cell activation. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: immune system process, protein polyubiquitination, protein ubiquitination, regulation of natural killer cell activation; MF: metal ion binding, protein binding, small molecule binding; CC: Cul4-RING E3 ubiquitin ligase complex
Pathways:
UniProt: Q66K64
Entrez ID: 90379
|
Does Knockout of SPDL1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
SPDL1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SPDL1 (spindle apparatus coiled-coil protein 1)
Type: protein-coding
Summary: This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: cell division, cell migration, establishment of mitotic spindle orientation, mitotic metaphase chromosome alignment, mitotic spindle assembly checkpoint signaling, protein localization to kinetochore; MF: enzyme binding, kinetochore binding, protein binding; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, nucleus, outer kinetochore, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q96EA4
Entrez ID: 54908
|
Does Knockout of KISS1R in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
KISS1R
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: KISS1R (KISS1 receptor)
Type: protein-coding
Summary: The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, neuropeptide signaling pathway, positive regulation of hormone secretion, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, neuropeptide receptor activity, protein binding; CC: cell surface, cilium, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GnRH secretion - Homo sapiens (human), Kisspeptin-kisspeptin receptor system in the ovary, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q969F8
Entrez ID: 84634
|
Does Knockout of LCLAT1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
LCLAT1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: LCLAT1 (lysocardiolipin acyltransferase 1)
Type: protein-coding
Summary: Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, cardiolipin acyl-chain remodeling, lipid metabolic process, phosphatidic acid biosynthetic process, phosphatidylinositol acyl-chain remodeling, phospholipid biosynthetic process; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, O-acyltransferase activity, acyltransferase activity, protein binding, transferase activity; CC: cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Acyl chain remodeling of CL, CDP-diacylglycerol biosynthesis, Glycerolipid metabolism - Homo sapiens (human), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA, triacylglycerol biosynthesis
UniProt: Q6UWP7
Entrez ID: 253558
|
Does Knockout of LAMTOR4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
LAMTOR4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: LAMTOR4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4)
Type: protein-coding
Summary: Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cellular response to amino acid stimulus; positive regulation of TOR signaling; and protein localization to lysosome. Located in lysosome. Part of Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: TORC1 signaling, cellular response to amino acid stimulus, positive regulation of TOR signaling, positive regulation of TORC1 signaling, protein localization to lysosome, regulation of cell size; MF: guanyl-nucleotide exchange factor activity, molecular adaptor activity, protein binding; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, late endosome membrane, lysosomal membrane, lysosome
Pathways: Amino acids regulate mTORC1, Autophagy, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Homo sapiens (human), mTORC1-mediated signalling
UniProt: Q0VGL1
Entrez ID: 389541
|
Does Knockout of RASGRF1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
RASGRF1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1)
Type: protein-coding
Summary: The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: Ras protein signal transduction, intracellular signal transduction, long-term memory, negative regulation of MAPK cascade, neuron projection development, positive regulation of MAPK cascade, positive regulation of Rac protein signal transduction, positive regulation of Ras protein signal transduction, regulation of Ras protein signal transduction, regulation of neuronal synaptic plasticity, regulation of synaptic plasticity, response to endoplasmic reticulum stress, signal transduction, small GTPase-mediated signal transduction, type B pancreatic cell proliferation; MF: glutamate receptor binding, guanyl-nucleotide exchange factor activity; CC: cytosol, growth cone, neuron projection, plasma membrane
Pathways: ATM Signaling Network in Development and Disease, Activation of NMDA receptors and postsynaptic events, Brain-derived neurotrophic factor (BDNF) signaling pathway, CDC42 signaling events, CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling, Focal Adhesion, Focal adhesion - Homo sapiens (human), MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neurotrophic factor-mediated Trk receptor signaling, Post NMDA receptor activation events, RAF/MAP kinase cascade, Ras activation upon Ca2+ influx through NMDA receptor, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of RAC1 activity, Regulation of Ras family activation, Serotonin Receptor 2 and ELK-SRF-GATA4 signaling, Signal Transduction, TFs regulate miRNAs related to cardiac hypertrophy, Transmission across Chemical Synapses, cdc25 and chk1 regulatory pathway in response to dna damage, cell cycle: g2/m checkpoint, p38 MAPK Signaling Pathway, rb tumor suppressor/checkpoint signaling in response to dna damage, regulation of cell cycle progression by plk3, sonic hedgehog receptor ptc1 regulates cell cycle
UniProt: Q13972
Entrez ID: 5923
|
Does Knockout of FRMPD4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
FRMPD4
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: FRMPD4 (FERM and PDZ domain containing 4)
Type: protein-coding
Summary: This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. [provided by RefSeq, Jan 2010].
Gene Ontology: MF: lipid binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: cell projection, dendritic spine, postsynapse, protein-containing complex, synapse
Pathways:
UniProt: Q14CM0
Entrez ID: 9758
|
Does Knockout of CDK2 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
CDK2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CDK2 (cyclin dependent kinase 2)
Type: protein-coding
Summary: This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA-templated transcription, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, Ras protein signal transduction, cell division, cellular response to nitric oxide, cellular senescence, centriole replication, centrosome duplication, chromatin remodeling, meiotic cell cycle, mitotic G1 DNA damage checkpoint signaling, negative regulation of transcription by RNA polymerase II, peptidyl-serine phosphorylation, positive regulation of DNA replication, positive regulation of DNA-templated DNA replication initiation, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of heterochromatin formation, post-translational protein modification, potassium ion transport, protection from non-homologous end joining at telomere, protein phosphorylation, regulation of G2/M transition of mitotic cell cycle, regulation of anaphase-promoting complex-dependent catabolic process, regulation of gene expression, regulation of mitotic cell cycle, signal transduction, telomere maintenance, telomere maintenance in response to DNA damage; MF: ATP binding, cyclin binding, cyclin-dependent protein kinase activity, cyclin-dependent protein serine/threonine kinase activity, histone kinase activity, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein domain specific binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Cajal body, X chromosome, Y chromosome, centrosome, chromosome, telomeric region, condensed chromosome, cyclin A1-CDK2 complex, cyclin A2-CDK2 complex, cyclin E1-CDK2 complex, cyclin E2-CDK2 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytoskeleton, cytosol, endosome, male germ cell nucleus, nuclear envelope, nucleoplasm, nucleus, transcription regulator complex
Pathways: APC/C-mediated degradation of cell cycle proteins, ATR signaling pathway, Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects, Aberrant regulation of mitotic cell cycle due to RB1 defects, Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Aryl Hydrocarbon Receptor Netpath, BARD1 signaling events, BCR, CDK-mediated phosphorylation and removal of Cdc6, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Homo sapiens (human), Chromosome Maintenance, Cushing syndrome - Homo sapiens (human), Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA Damage/Telomere Stress Induced Senescence, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, DNA damage response, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3), Developmental Biology, Disease, Diseases of mitotic cell cycle, E2F transcription factor network, EGFR1, Epstein-Barr virus infection - Homo sapiens (human), Extension of Telomeres, FOXM1 transcription factor network, Factors involved in megakaryocyte development and platelet production, FoxO family signaling, FoxO signaling pathway - Homo sapiens (human), G0 and Early G1, G1 Phase, G1 to S cell cycle control, G1/S DNA Damage Checkpoints, G1/S Transition, G2 Phase, G2/M Checkpoints, G2/M Transition, Gastric cancer - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, Glioblastoma signaling pathways, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hemostasis, Hepatitis B - Homo sapiens (human), Hepatitis C - Homo sapiens (human), Homology Directed Repair, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), ID, ID signaling pathway, IL2, IL2-mediated signaling events, KitReceptor, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Measles - Homo sapiens (human), Meiosis, Meiotic recombination, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Oncostatin M Signaling Pathway, Oocyte meiosis - Homo sapiens (human), Orc1 removal from chromatin, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PTK6 Regulates Cell Cycle, Pathways in cancer - Homo sapiens (human), Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, Processing of DNA double-strand break ends, Progesterone-mediated oocyte maturation - Homo sapiens (human), Prostate cancer - Homo sapiens (human), RAGE, RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of mitotic cell cycle, Regulation of nuclear SMAD2/3 signaling, Regulation of retinoblastoma protein, Reproduction, Retinoblastoma gene in cancer, S Phase, SCF(Skp2)-mediated degradation of p27/p21, Senescence-Associated Secretory Phenotype (SASP), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling events mediated by PRL, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Spinal Cord Injury, Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, Telomere Extension By Telomerase, Telomere Maintenance, Thyroid stimulating hormone (TSH) signaling pathway, Transcriptional Regulation by TP53, Transcriptional regulation of granulopoiesis, Viral carcinogenesis - Homo sapiens (human), Vitamin D Receptor Pathway, cdk regulation of dna replication, cell cycle: g1/s check point, cyclin e destruction pathway, cyclins and cell cycle regulation, e2f1 destruction pathway, estrogen responsive protein efp controls cell cycle and breast tumors growth, influence of ras and rho proteins on g1 to s transition, mTOR signaling pathway, miRNA regulation of DNA damage response, p53 pathway, p53 signaling pathway, p53 signaling pathway - Homo sapiens (human), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p73 transcription factor network, rb tumor suppressor/checkpoint signaling in response to dna damage, regulation of p27 phosphorylation during cell cycle progression
UniProt: P24941
Entrez ID: 1017
|
Does Knockout of FAM43B in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
FAM43B
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: FAM43B (family with sequence similarity 43 member B)
Type: protein-coding
Summary: family with sequence similarity 43 member B
Gene Ontology:
Pathways:
UniProt: Q6ZT52
Entrez ID: 163933
|
Does Knockout of PCM1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
PCM1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: PCM1 (pericentriolar material 1)
Type: protein-coding
Summary: The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: cell projection organization, centrosome cycle, cilium assembly, cytoplasmic microtubule organization, interkinetic nuclear migration, intraciliary transport involved in cilium assembly, microtubule anchoring, microtubule anchoring at centrosome, negative regulation of neurogenesis, neuron migration, neuronal stem cell population maintenance, non-motile cilium assembly, positive regulation of intracellular protein transport, protein localization to centrosome, protein localization to organelle, protein-containing complex localization to centriolar satellite, regulation of protein complex stability, social behavior; MF: identical protein binding, molecular adaptor activity, protein binding; CC: apical part of cell, cell projection, centriolar satellite, centriole, centrosome, ciliary basal body, ciliary transition zone, cilium, cytoplasm, cytoskeleton, cytosol, membrane, microtubule cytoskeleton, non-motile cilium, nuclear membrane, nucleoplasm, pericentriolar material, protein-containing complex
Pathways: Joubert Syndrome, Prader-Willi and Angelman Syndrome
UniProt: Q15154
Entrez ID: 5108
|
Does Knockout of CDH17 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
CDH17
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: CDH17 (cadherin 17)
Type: protein-coding
Summary: This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009].
Gene Ontology: BP: B cell differentiation, adherens junction organization, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, germinal center B cell differentiation, homophilic cell adhesion via plasma membrane adhesion molecules, integrin-mediated signaling pathway, marginal zone B cell differentiation, oligopeptide transmembrane transport, oligopeptide transport, positive regulation of integrin activation by cell surface receptor linked signal transduction, spleen development; MF: beta-catenin binding, cadherin binding, calcium ion binding, integrin binding, metal ion binding, protein binding, proton-dependent oligopeptide secondary active transmembrane transporter activity; CC: adherens junction, basolateral plasma membrane, catenin complex, cell junction, cell surface, membrane, nucleoplasm, plasma membrane
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Gastric cancer - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Pathways Regulating Hippo Signaling
UniProt: Q12864
Entrez ID: 1015
|
Does Knockout of RAB7A in Huh-7 Cell causally result in response to virus?
| 1
| 1,382
|
Knockout
|
RAB7A
|
response to virus
|
Huh-7 Cell
|
Gene: RAB7A (RAB7A, member RAS oncogene family)
Type: protein-coding
Summary: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: autophagosome assembly, autophagy, bone resorption, early endosome to late endosome transport, endocytosis, endosome to lysosome transport, endosome to plasma membrane protein transport, epidermal growth factor catabolic process, establishment of vesicle localization, lipid catabolic process, lipid metabolic process, lipophagy, negative regulation of exosomal secretion, negative regulation of intralumenal vesicle formation, neurotransmitter receptor transport, postsynaptic endosome to lysosome, phagosome acidification, phagosome maturation, phagosome-lysosome fusion, positive regulation of exosomal secretion, positive regulation of protein catabolic process, positive regulation of viral process, protein localization to lysosome, protein targeting to lysosome, protein to membrane docking, protein transport, response to bacterium, retrograde transport, endosome to Golgi, synaptic vesicle recycling via endosome, vesicle-mediated transport in synapse, viral release from host cell; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding, retromer complex binding, small GTPase binding; CC: Golgi apparatus, alveolar lamellar body, autophagosome membrane, bounding membrane of organelle, cytoplasm, cytoplasmic vesicle, cytosol, endosome, endosome membrane, extracellular exosome, glutamatergic synapse, late endosome, late endosome membrane, lipid droplet, lysosomal membrane, lysosome, melanosome membrane, membrane, mitochondrial membrane, mitochondrion, phagocytic vesicle, phagocytic vesicle membrane, phagophore assembly site membrane, plasma membrane, presynaptic endosome, retromer complex, secretory granule membrane, synaptic vesicle membrane
Pathways: Adaptive Immune System, Amoebiasis - Homo sapiens (human), Autophagy - animal - Homo sapiens (human), Autosomal recessive Osteopetrosis pathways, Bacterial Infection Pathways, CDC42 GTPase cycle, Disease, Ebola Virus Pathway on Host, Endocytosis - Homo sapiens (human), IL12-mediated signaling events, IL8- and CXCR2-mediated signaling events, Immune System, Infection with Mycobacterium tuberculosis, Infectious disease, Innate Immune System, Intracellular trafficking proteins involved in CMT neuropathy, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitophagy - animal - Homo sapiens (human), Neutrophil degranulation, Phagosome - Homo sapiens (human), Post-translational protein modification, Posttranslational regulation of adherens junction stability and dissassembly, Prevention of phagosomal-lysosomal fusion, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, RHOH GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, Rab regulation of trafficking, Response of Mtb to phagocytosis, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Suppression of autophagy, Suppression of phagosomal maturation, TBC/RABGAPs, Tuberculosis - Homo sapiens (human), Vesicle-mediated transport
UniProt: P51149
Entrez ID: 7879
|
Does Knockout of RBSN in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
RBSN
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: RBSN (rabenosyn, RAB effector)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: Golgi to lysosome transport, early endosome to Golgi transport, endosomal transport, protein transport, regulation of Golgi organization; MF: metal ion binding, phosphatidylinositol-3-phosphate binding, protein binding, small GTPase binding, zinc ion binding; CC: cytosol, early endosome, early endosome membrane, endosome, endosome membrane, extracellular exosome, membrane, plasma membrane
Pathways: Endocytosis - Homo sapiens (human), Factors involved in megakaryocyte development and platelet production, Hemostasis, Immune System, Innate Immune System, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades
UniProt: Q9H1K0
Entrez ID: 64145
|
Does Knockout of RPS9 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
RPS9
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPS9 (ribosomal protein S9)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, ribosomal small subunit biogenesis, translation; MF: RNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46781
Entrez ID: 6203
|
Does Knockout of FCMR in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
FCMR
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: FCMR (Fc mu receptor)
Type: protein-coding
Summary: Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010].
Gene Ontology: BP: Fc receptor signaling pathway, Fc receptor-mediated immune complex endocytosis, cellular defense response, humoral immune response mediated by circulating immunoglobulin, immune system process, immunoglobulin transcytosis in epithelial cells, negative regulation of apoptotic process, regulation of B cell receptor signaling pathway, signal transduction; MF: IgM binding, high-affinity IgM receptor activity, polymeric immunoglobulin binding, protein binding, transmembrane signaling receptor activity; CC: Golgi apparatus, centrosome, early endosome membrane, endosome, extracellular region, lysosomal membrane, lysosome, membrane, nucleoplasm, plasma membrane, trans-Golgi network membrane
Pathways:
UniProt: O60667
Entrez ID: 9214
|
Does Knockout of HOXC11 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
HOXC11
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: HOXC11 (homeobox C11)
Type: protein-coding
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anterior/posterior pattern specification, embryonic digit morphogenesis, embryonic skeletal joint morphogenesis, endoderm development, metanephros development, organ induction, positive regulation of transcription by RNA polymerase II, proximal/distal pattern formation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal system development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytosol, nucleoplasm, nucleus
Pathways: Developmental Biology, Endoderm differentiation, Formation of the ureteric bud, Kidney development
UniProt: O43248
Entrez ID: 3227
|
Does Knockout of AP1B1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
AP1B1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: AP1B1 (adaptor related protein complex 1 subunit beta 1)
Type: protein-coding
Summary: Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: basolateral protein secretion, determination of left/right symmetry, heart development, intracellular protein transport, kidney development, melanosome assembly, platelet dense granule organization, protein transport, vesicle-mediated transport; MF: clathrin binding, protein binding, protein kinase binding; CC: AP-1 adaptor complex, Golgi apparatus, Golgi membrane, clathrin adaptor complex, clathrin-coated vesicle membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, early endosome, endomembrane system, lysosomal membrane, membrane, membrane coat, synaptic vesicle, trans-Golgi network membrane
Pathways: FOXA1 transcription factor network, Fibroblast growth factor-1, Human immunodeficiency virus 1 infection - Homo sapiens (human), Lysosome - Homo sapiens (human), Validated nuclear estrogen receptor alpha network
UniProt: Q10567
Entrez ID: 162
|
Does Knockout of AGAP4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
AGAP4
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: AGAP4 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 4)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in regulation of catalytic activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase activator activity, GTPase activity, metal ion binding, zinc ion binding
Pathways: Endocytosis - Homo sapiens (human)
UniProt: Q96P64
Entrez ID: 119016
|
Does Knockout of MINDY4 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
MINDY4
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: MINDY4 (MINDY lysine 48 deubiquitinase 4)
Type: protein-coding
Summary: Predicted to enable Lys48-specific deubiquitinase activity. Predicted to be involved in protein K48-linked deubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein K48-linked deubiquitination, proteolysis; MF: K48-linked deubiquitinase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity
Pathways:
UniProt: Q4G0A6
Entrez ID: 84182
|
Does Knockout of SLC30A6 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
SLC30A6
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: SLC30A6 (solute carrier family 30 member 6)
Type: protein-coding
Summary: This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: monoatomic cation transport, monoatomic ion transport, regulation of zinc ion transport, transmembrane transport, zinc ion import into Golgi lumen, zinc ion transport; MF: antiporter activity, monoatomic cation transmembrane transporter activity, protein binding, zinc ion transmembrane transporter activity, zinc:proton antiporter activity; CC: Golgi apparatus, membrane, trans-Golgi network membrane
Pathways: Zinc homeostasis
UniProt: Q6NXT4
Entrez ID: 55676
|
Does Knockout of DEFB116 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
DEFB116
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: DEFB116 (defensin beta 116)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: defense response, defense response to bacterium, innate immune response
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q30KQ4
Entrez ID: 245930
|
Does Knockout of XPO1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
XPO1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: XPO1 (exportin 1)
Type: protein-coding
Summary: This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: cellular response to salt, cellular response to triglyceride, intracellular protein transport, mRNA export from nucleus, mRNA transport, negative regulation of transcription by RNA polymerase II, nucleocytoplasmic transport, protein export from nucleus, protein localization to nucleus, protein transport, regulation of centrosome duplication, regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of protein catabolic process, regulation of protein export from nucleus, response to xenobiotic stimulus, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus, ribosomal subunit export from nucleus, ribosome biogenesis; MF: DNA-binding transcription factor binding, RNA binding, nuclear export signal receptor activity, protein binding, protein domain specific binding, small GTPase binding; CC: Cajal body, annulate lamellae, cytoplasm, cytosol, kinetochore, membrane, nuclear envelope, nuclear membrane, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex
Pathways: 22q11.2 copy number variation syndrome, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Canonical NF-kappaB pathway, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Cyclin A/B1/B2 associated events during G2/M transition, Deactivation of the beta-catenin transactivating complex, Developmental Biology, Disease, Downregulation of TGF-beta receptor signaling, EML4 and NUDC in mitotic spindle formation, ESR-mediated signaling, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Export of Viral Ribonucleoproteins from Nucleus, Extra-nuclear estrogen signaling, Fibroblast growth factor-1, FoxO family signaling, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, Hedgehog signaling events mediated by Gli proteins, Heme signaling, Host Interactions of HIV factors, HuR (ELAVL1) binds and stabilizes mRNA, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Infectious disease, Influenza A - Homo sapiens (human), Influenza Infection, Integrin-linked kinase signaling, Interactions of Rev with host cellular proteins, Late Phase of HIV Life Cycle, M Phase, MAPK family signaling cascades, MAPK6/MAPK4 signaling, MITF-M-regulated melanocyte development, Maturation of hRSV A proteins, Metabolism of RNA, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, NEP/NS2 Interacts with the Cellular Export Machinery, NPAS4 regulates expression of target genes, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, RNA transport - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of nuclear beta catenin signaling and target gene transcription, Resolution of Sister Chromatid Cohesion, Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) genome replication, transcription and translation, Rev-mediated nuclear export of HIV RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Role of Calcineurin-dependent NFAT signaling in lymphocytes, Separation of Sister Chromatids, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TCF dependent signaling in response to WNT, TGF-beta receptor signaling activates SMADs, TGF_beta_Receptor, Transcriptional Regulation by NPAS4, Transcriptional and post-translational regulation of MITF-M expression and activity, Viral Infection Pathways, eIF5A regulation in response to inhibition of the nuclear export system, regulation of spermatogenesis by crem, sonic hedgehog receptor ptc1 regulates cell cycle
UniProt: O14980
Entrez ID: 7514
|
Does Knockout of RPL21 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
RPL21
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: RPL21 (ribosomal protein L21)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, membrane, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46778
Entrez ID: 6144
|
Does Knockout of SPATA31A7 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
SPATA31A7
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: SPATA31A7 (SPATA31 subfamily A member 7)
Type: protein-coding
Summary: Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, spermatogenesis
Pathways:
UniProt: Q8IWB4
Entrez ID: 26165
|
Does Knockout of PCCA in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
PCCA
|
cell proliferation
|
T-lymphoma cell line
|
Gene: PCCA (propionyl-CoA carboxylase subunit alpha)
Type: protein-coding
Summary: The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].
Gene Ontology: BP: branched-chain amino acid metabolic process, fatty acid metabolic process, lipid catabolic process, lipid metabolic process, short-chain fatty acid catabolic process; MF: ATP binding, biotin binding, enzyme binding, ligase activity, ligase activity, forming carbon-carbon bonds, metal ion binding, nucleotide binding, propionyl-CoA carboxylase activity, protein binding; CC: catalytic complex, cytosol, mitochondrial matrix, mitochondrion
Pathways: 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency, 2-oxobutanoate degradation, 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency, 3-Methylcrotonyl Coa Carboxylase Deficiency Type I, 3-Methylglutaconic Aciduria Type I, 3-Methylglutaconic Aciduria Type III, 3-Methylglutaconic Aciduria Type IV, 3-hydroxyisobutyric acid dehydrogenase deficiency, 3-hydroxyisobutyric aciduria, Beta-Ketothiolase Deficiency, Biotin transport and metabolism, Defective HLCS causes multiple carboxylase deficiency, Defects in biotin (Btn) metabolism, Defects in vitamin and cofactor metabolism, Disease, Diseases of metabolism, Fatty acid metabolism, Glyoxylate and dicarboxylate metabolism - Homo sapiens (human), Isobutyryl-coa dehydrogenase deficiency, Isovaleric Aciduria, Isovaleric acidemia, Malonic Aciduria, Malonyl-coa decarboxylase deficiency, Maple Syrup Urine Disease, Metabolism, Metabolism of lipids, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Methylmalonate Semialdehyde Dehydrogenase Deficiency, Methylmalonic Aciduria, Methylmalonic Aciduria Due to Cobalamin-Related Disorders, Mitochondrial Fatty Acid Beta-Oxidation, Propanoate Metabolism, Propanoate metabolism - Homo sapiens (human), Propionic Acidemia, Propionyl-CoA catabolism, Threonine and 2-Oxobutanoate Degradation, Valine, Leucine and Isoleucine Degradation, Valine, leucine and isoleucine degradation - Homo sapiens (human), propionyl-CoA degradation, superpathway of methionine degradation
UniProt: P05165
Entrez ID: 5095
|
Does Knockout of DDX27 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
DDX27
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: DDX27 (DEAD-box helicase 27)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: chromosome, nucleolus, nucleus
Pathways:
UniProt: Q96GQ7
Entrez ID: 55661
|
Does Inhibition of NUP205 in Mammary Epithelial Cell Line causally result in cell proliferation?
| 1
| 2,248
|
Inhibition
|
NUP205
|
cell proliferation
|
Mammary Epithelial Cell Line
|
Gene: NUP205 (nucleoporin 205)
Type: protein-coding
Summary: This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with steroid-resistant nephrotic syndrome. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: mRNA transport, nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport, protein transport; MF: protein binding, structural constituent of nuclear pore; CC: cytosol, membrane, nuclear envelope, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q92621
Entrez ID: 23165
|
Does Knockout of CCT4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
CCT4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CCT4 (chaperonin containing TCP1 subunit 4)
Type: protein-coding
Summary: The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of protein localization to Cajal body, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, scaRNA localization to Cajal body; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, RNA binding, hydrolase activity, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, cell projection, centrosome, chaperonin-containing T-complex, cytoplasm, cytoskeleton, cytosol, extracellular exosome, melanosome, microtubule, nucleoplasm, zona pellucida receptor complex
Pathways: 16p11.2 proximal deletion syndrome, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Chaperonin-mediated protein folding, Cilium Assembly, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Folding of actin by CCT/TriC, Formation of tubulin folding intermediates by CCT/TriC, Metabolism of proteins, Organelle biogenesis and maintenance, Prefoldin mediated transfer of substrate to CCT/TriC, Protein folding, b cell survival pathway
UniProt: P50991
Entrez ID: 10575
|
Does Knockout of MRPL44 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
MRPL44
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: MRPL44 (mitochondrial ribosomal protein L44)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA processing, mitochondrial translation, mitochondrial translational elongation; MF: RNA binding, double-stranded RNA binding, endonuclease activity, hydrolase activity, nuclease activity, protein binding, ribonuclease III activity; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nuclear body, nucleoplasm, nucleus, plasma membrane, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q9H9J2
Entrez ID: 65080
|
Does Knockout of NEURL1B in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
NEURL1B
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: NEURL1B (neuralized E3 ubiquitin protein ligase 1B)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent endocytosis. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Notch signaling pathway, protein ubiquitination, ubiquitin-dependent endocytosis; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: actin cytoskeleton, cytoplasm, cytosol, early endosome
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Disease, Diseases of signal transduction by growth factor receptors and second messengers, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD Domain Mutants in Cancer, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH2, Signaling by NOTCH3
UniProt: A8MQ27
Entrez ID: 54492
|
Does Knockout of CDC123 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
CDC123
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CDC123 (cell division cycle 123)
Type: protein-coding
Summary: Predicted to be involved in eukaryotic translation initiation factor 2 complex assembly and positive regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: eukaryotic translation initiation factor 2 complex assembly, protein folding; MF: ATP binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein folding chaperone; CC: cytoplasm
Pathways:
UniProt: O75794
Entrez ID: 8872
|
Does Knockout of OTOP2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
OTOP2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: OTOP2 (otopetrin 2)
Type: protein-coding
Summary: Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, proton transmembrane transport; MF: protein binding, proton channel activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q7RTS6
Entrez ID: 92736
|
Does Knockout of ACSL6 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
ACSL6
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ACSL6 (acyl-CoA synthetase long chain family member 6)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011].
Gene Ontology: BP: acyl-CoA metabolic process, fatty acid metabolic process, lipid metabolic process, long-chain fatty acid metabolic process, long-chain fatty-acyl-CoA biosynthetic process, neuroblast proliferation, very long-chain fatty acid metabolic process; MF: ATP binding, arachidonate-CoA ligase activity, enzyme binding, ligase activity, long-chain fatty acid-CoA ligase activity, nucleotide binding, protein binding, protein homodimerization activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion, peroxisomal membrane, peroxisome, plasma membrane
Pathways: γ-linolenate biosynthesis, Adipocytokine signaling pathway - Homo sapiens (human), Fatty Acid Biosynthesis, Fatty acid beta-oxidation, Fatty acid biosynthesis - Homo sapiens (human), Fatty acid degradation - Homo sapiens (human), Fatty acid metabolism, Fatty acid transporters, Fatty acyl-CoA biosynthesis, Ferroptosis, Ferroptosis - Homo sapiens (human), Metabolism, Metabolism of lipids, PPAR signaling pathway, PPAR signaling pathway - Homo sapiens (human), Peroxisome - Homo sapiens (human), Synthesis of very long-chain fatty acyl-CoAs, Thermogenesis, Thermogenesis - Homo sapiens (human), eicosapentaenoate biosynthesis, fatty acid β-oxidation, fatty acid β-oxidation (peroxisome), fatty acid activation
UniProt: Q9UKU0
Entrez ID: 23305
|
Does Knockout of COX20 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
COX20
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: COX20 (cytochrome c oxidase assembly factor COX20)
Type: protein-coding
Summary: This gene encodes a protein that plays a role in the assembly of cytochrome C oxidase, an important component of the respiratory pathway. It contains two transmembrane helices and localizes to the mitochondrial membrane. Mutations in this gene can cause mitochondrial complex IV deficiency, which results in ataxia and muscle hypotonia. There are multiple pseudogenes for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Mitochondrial CIV Assembly, Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: Q5RI15
Entrez ID: 116228
|
Does Knockout of RPL31 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
RPL31
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: RPL31 (ribosomal protein L31)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, large ribosomal subunit, membrane, nucleoplasm, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62899
Entrez ID: 6160
|
Does Knockout of PIANP in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
PIANP
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: PIANP (PILR alpha associated neural protein)
Type: protein-coding
Summary: This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: cerebellum development, dentate gyrus development, gamma-aminobutyric acid signaling pathway, gene expression, glutamate secretion, homeostasis of number of cells, regulation of immune response, response to stress, social behavior, visual learning; MF: protein binding, protein domain specific binding; CC: basolateral plasma membrane, membrane, plasma membrane, presynapse
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
UniProt: Q8IYJ0
Entrez ID: 196500
|
Does Knockout of SAAL1 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
SAAL1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: SAAL1 (serum amyloid A like 1)
Type: protein-coding
Summary: Acts upstream of or within positive regulation of synoviocyte proliferation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of synoviocyte proliferation; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q96ER3
Entrez ID: 113174
|
Does Knockout of NDUFAB1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
NDUFAB1
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1)
Type: protein-coding
Summary: Predicted to enable acyl binding activity; acyl carrier activity; and fatty acid binding activity. Involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Located in mitochondrion and nucleoplasm. Part of mitochondrial respiratory chain complex I. Colocalizes with mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: [2Fe-2S] cluster assembly, aerobic respiration, fatty acid biosynthetic process, fatty acid metabolic process, iron-sulfur cluster assembly, lipid metabolic process, mitochondrial electron transport, NADH to ubiquinone, protein lipoylation, proton motive force-driven mitochondrial ATP synthesis; MF: acyl binding, acyl carrier activity, calcium ion binding, fatty acid binding, mitochondrial large ribosomal subunit binding, protein binding, structural molecule activity; CC: iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleoplasm, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Fatty acid metabolism, Huntington disease - Homo sapiens (human), Metabolism, Metabolism of lipids, Metabolism of proteins, Mitochondrial Fatty Acid Beta-Oxidation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Protein lipoylation, Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human), Translation
UniProt: O14561
Entrez ID: 4706
|
Does Knockout of CTRB1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
CTRB1
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: CTRB1 (chymotrypsinogen B1)
Type: protein-coding
Summary: This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This CTRB1 gene is located head-to-head with the related CTRB2 gene. Some human populations have an alternate haplotype which inverts a 16.6 Kb region containing portions of intron 1, exon 1, and the upstream sequence of the CTRB1 and CTRB2 genes. In this inversion haplotype exon 1 and flanking sequence is swapped in CTRB1 and CTRB2. This inversion is associated with differential gene expression and increased risk for chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 of the CTRB1 gene. SNP rs8048956 in intron 1 of the CTRB2 gene is diagnostic for this inversion. This CTRB1 gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jan 2021].
Gene Ontology: BP: digestion, proteolysis; MF: hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region
Pathways: Activation of Matrix Metalloproteinases, Cobalamin (Cbl, vitamin B12) transport and metabolism, Degradation of the extracellular matrix, Extracellular matrix organization, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pancreatic secretion - Homo sapiens (human), Protein digestion and absorption - Homo sapiens (human), Uptake of dietary cobalamins into enterocytes
UniProt: P17538
Entrez ID: 1504
|
Does Knockout of MIR4743 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
MIR4743
|
response to virus
|
Hepatoma Cell Line
|
Gene: MIR4743 (microRNA 4743)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100616366
|
Does Knockout of NCBP2 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
NCBP2
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: NCBP2 (nuclear cap binding protein subunit 2)
Type: protein-coding
Summary: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, cap-dependent translational initiation, histone mRNA metabolic process, mRNA 3'-end processing, mRNA cis splicing, via spliceosome, mRNA export from nucleus, mRNA metabolic process, mRNA processing, mRNA splicing, via spliceosome, mRNA transcription by RNA polymerase II, mRNA transport, miRNA-mediated post-transcriptional gene silencing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of RNA export from nucleus, positive regulation of mRNA 3'-end processing, positive regulation of transcription elongation by RNA polymerase II, primary miRNA processing, regulation of translation, regulation of translational initiation, regulatory ncRNA-mediated gene silencing, regulatory ncRNA-mediated post-transcriptional gene silencing, snRNA export from nucleus; MF: DNA binding, RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, mRNA binding, nucleic acid binding, protein binding, snRNA binding; CC: RNA cap binding complex, ciliary basal body, cytoplasm, cytosol, nuclear cap binding complex, nucleoplasm, nucleus
Pathways: 3q29 copy number variation syndrome, RNA transport - Homo sapiens (human), Spliceosome - Homo sapiens (human), mRNA Processing, mRNA surveillance pathway - Homo sapiens (human)
UniProt: P52298
Entrez ID: 22916
|
Does Knockout of SNRPD1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
SNRPD1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide)
Type: protein-coding
Summary: This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
Gene Ontology: BP: 7-methylguanosine cap hypermethylation, RNA processing, RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, spliceosomal complex assembly, spliceosomal snRNP assembly; MF: RNA binding, U1 snRNP binding, protein binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, commitment complex, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, pICln-Sm protein complex, precatalytic spliceosome, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Disease, Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, Spliceosome - Homo sapiens (human), Systemic lupus erythematosus - Homo sapiens (human), Viral Infection Pathways, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62314
Entrez ID: 6632
|
Does Knockout of RAB11FIP4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
RAB11FIP4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RAB11FIP4 (RAB11 family interacting protein 4)
Type: protein-coding
Summary: The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: endocytic recycling, neural retina development, positive regulation of G1 to G0 transition, regulation of cytokinesis; MF: calcium ion binding, metal ion binding, protein binding, protein homodimerization activity, small GTPase binding; CC: Golgi apparatus, centrosome, cleavage furrow, cytoplasm, cytoplasmic vesicle, cytoskeleton, endocytic vesicle, endosome, extracellular space, membrane, midbody, perinuclear region of cytoplasm, recycling endosome membrane, spindle
Pathways: Endocytosis - Homo sapiens (human)
UniProt: Q86YS3
Entrez ID: 84440
|
Does Knockout of PRAC1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
PRAC1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PRAC1 (PRAC1 small nuclear protein)
Type: protein-coding
Summary: This gene is reported to be specifically expressed in prostate, rectum and distal colon. Sequence analysis suggests that it may play a regulatory role in the nucleus. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q96KF2
Entrez ID: 84366
|
Does Knockout of TPI1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
TPI1
|
cell proliferation
|
Cancer Cell Line
|
Gene: TPI1 (triosephosphate isomerase 1)
Type: protein-coding
Summary: This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].
Gene Ontology: BP: canonical glycolysis, gluconeogenesis, glucose metabolic process, glyceraldehyde-3-phosphate biosynthetic process, glyceraldehyde-3-phosphate metabolic process, glycerol catabolic process, glycolytic process, methylglyoxal biosynthetic process; MF: isomerase activity, lyase activity, methylglyoxal synthase activity, protein binding, protein homodimerization activity, triose-phosphate isomerase activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, extracellular exosome, extracellular space, nucleus
Pathways: Computational Model of Aerobic Glycolysis, Cori Cycle, Fanconi-bickel syndrome, Fatty acid beta-oxidation, Fructose and Mannose Degradation, Fructose and mannose metabolism - Homo sapiens (human), Fructose intolerance, hereditary, Fructose-1,6-diphosphatase deficiency, Fructosuria, Gluconeogenesis, Glucose metabolism, Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycogenosis, Type VII. Tarui disease, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, HIF1A and PPARG regulation of glycolysis, Inositol phosphate metabolism - Homo sapiens (human), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pathways in clear cell renal cell carcinoma, Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Triosephosphate isomerase, gluconeogenesis, glycolysis, sucrose degradation, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P60174
Entrez ID: 7167
|
Does Knockout of KIAA1671 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
KIAA1671
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: KIAA1671 (KIAA1671)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cilium, intercellular bridge, microtubule cytoskeleton
Pathways:
UniProt: Q9BY89
Entrez ID: 85379
|
Does Knockout of P2RX6 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
P2RX6
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: P2RX6 (purinergic receptor P2X 6)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009].
Gene Ontology: BP: calcium ion transmembrane transport, excitatory postsynaptic potential, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, muscle contraction, purinergic nucleotide receptor signaling pathway, response to ATP, signal transduction; MF: ATP binding, channel activity, extracellularly ATP-gated monoatomic cation channel activity, monoatomic ion channel activity, protein-containing complex binding, purinergic nucleotide receptor activity, transmembrane signaling receptor activity; CC: cell junction, cytoplasm, dendritic spine, endoplasmic reticulum, endoplasmic reticulum membrane, glutamatergic synapse, membrane, neuronal cell body, nuclear inner membrane, nucleus, parallel fiber to Purkinje cell synapse, plasma membrane, postsynaptic specialization membrane, receptor complex
Pathways: 22q11.2 copy number variation syndrome, Calcium signaling pathway - Homo sapiens (human), Elevation of cytosolic Ca2+ levels, Hemostasis, Neuroactive ligand-receptor interaction - Homo sapiens (human), Platelet calcium homeostasis, Platelet homeostasis, Purinergic signaling
UniProt: O15547
Entrez ID: 9127
|
Does Knockout of RFFL in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
RFFL
|
cell proliferation
|
Cancer Cell Line
|
Gene: RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase)
Type: protein-coding
Summary: Enables enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in cellular protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; and negative regulation of signal transduction. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, intracellular protein transport, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of signal transduction by p53 class mediator, negative regulation of tumor necrosis factor-mediated signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein ubiquitination, regulation of TOR signaling, regulation of fibroblast migration, regulation of signal transduction by p53 class mediator, ubiquitin-dependent protein catabolic process; MF: metal ion binding, p53 binding, protease binding, protein binding, protein kinase binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, zinc ion binding; CC: Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endosome, endosome membrane, lysosome, membrane, nucleoplasm, plasma membrane, recycling endosome membrane
Pathways: TNF receptor signaling pathway , TNF-alpha signaling pathway, TNFalpha
UniProt: Q8WZ73
Entrez ID: 117584
|
Does Knockout of CHCHD6 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
CHCHD6
|
response to virus
|
Hepatoma Cell Line
|
Gene: CHCHD6 (coiled-coil-helix-coiled-coil-helix domain containing 6)
Type: protein-coding
Summary: Involved in cellular response to DNA damage stimulus and cristae formation. Located in cytosol and mitochondrial inner membrane. Part of MICOS complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, cristae formation, inner mitochondrial membrane organization; CC: MIB complex, MICOS complex, SAM complex, cytosol, membrane, mitochondrial crista junction, mitochondrial inner membrane, mitochondrion
Pathways: Cristae formation, Mitochondrial biogenesis, Organelle biogenesis and maintenance
UniProt: Q9BRQ6
Entrez ID: 84303
|
Does Knockout of P3H3 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
P3H3
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: P3H3 (prolyl 3-hydroxylase 3)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: collagen biosynthetic process, collagen metabolic process, negative regulation of cell population proliferation, peptidyl-lysine hydroxylation; MF: L-ascorbic acid binding, dioxygenase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, procollagen-proline 3-dioxygenase activity, protein binding; CC: catalytic complex, endoplasmic reticulum
Pathways:
UniProt: Q8IVL6
Entrez ID: 10536
|
Does Knockout of COQ2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
COQ2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: COQ2 (coenzyme Q2, polyprenyltransferase)
Type: protein-coding
Summary: This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: glycerol metabolic process, isoprenoid biosynthetic process, ubiquinone biosynthetic process; MF: 4-hydroxybenzoate polyprenyltransferase activity, prenyltransferase activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: extrinsic component of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion
Pathways: Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Mitochondrial protein import, Nephrotic syndrome, Protein localization, Ubiquinol biosynthesis, Ubiquinone Biosynthesis, Ubiquinone and other terpenoid-quinone biosynthesis - Homo sapiens (human), ubiquinol-10 biosynthesis
UniProt: Q96H96
Entrez ID: 27235
|
Does Knockout of EIF4E in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
EIF4E
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: EIF4E (eukaryotic translation initiation factor 4E)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, behavioral fear response, cellular response to dexamethasone stimulus, mRNA export from nucleus, mRNA transport, negative regulation of autophagy, negative regulation of neuron differentiation, negative regulation of translation, neuron differentiation, nuclear export, positive regulation of mitotic cell cycle, regulation of translation, regulation of translation at postsynapse, modulating synaptic transmission, stem cell population maintenance, translation, translational initiation; MF: DNA-binding transcription factor binding, RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, enzyme binding, eukaryotic initiation factor 4G binding, mRNA cap binding, protein binding, translation initiation factor activity; CC: P-body, RISC complex, chromatoid body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, eukaryotic translation initiation factor 4F complex, extracellular exosome, glutamatergic synapse, nuclear body, nuclear speck, nucleus, perinuclear region of cytoplasm, postsynapse
Pathways: 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression, Alpha6Beta4Integrin, Angiopoietin Like Protein 8 Regulatory Pathway, Brain-derived neurotrophic factor (BDNF) signaling pathway, EGFR Tyrosine Kinase Inhibitor Resistance, Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Fragile X Syndrome, HIF-1 signaling pathway - Homo sapiens (human), Head and Neck Squamous Cell Carcinoma, Host-pathogen interaction of human coronaviruses - MAPK signaling, Hypertrophy Model, IL2, IL6, Insulin Signaling, Insulin signaling pathway - Homo sapiens (human), Interferon type I signaling pathways, Leptin, Leptin signaling pathway, Leucine Stimulation on Insulin Signaling, Longevity regulating pathway - Homo sapiens (human), Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), RNA transport - Homo sapiens (human), Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling mediated by p38-alpha and p38-beta, Structural Pathway of Interleukin 1 (IL-1), TSLP, Translation Factors, Translation inhibitors in chronically activated PDGFRA cells, VEGFA-VEGFR2 Signaling Pathway, Validated targets of C-MYC transcriptional activation, eukaryotic protein translation, internal ribosome entry pathway, mTOR signaling pathway, mTOR signaling pathway - Homo sapiens (human), mtor signaling pathway, regulation of eif-4e and p70s6 kinase, skeletal muscle hypertrophy is regulated via akt-mtor pathway
UniProt: P06730
Entrez ID: 1977
|
Does Knockout of BAD in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
BAD
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: BAD (BCL2 associated agonist of cell death)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019].
Gene Ontology: BP: ADP metabolic process, ATP metabolic process, apoptotic process, apoptotic signaling pathway, cellular response to hypoxia, cellular response to lipid, cellular response to mechanical stimulus, cellular response to nicotine, cytokine-mediated signaling pathway, epithelial cell proliferation, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway in absence of ligand, extrinsic apoptotic signaling pathway via death domain receptors, glucose catabolic process, glucose homeostasis, intrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of apoptotic process, pore complex assembly, positive regulation of B cell differentiation, positive regulation of T cell differentiation, positive regulation of apoptotic process, positive regulation of autophagy, positive regulation of epithelial cell proliferation, positive regulation of insulin secretion, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress, positive regulation of mitochondrial membrane potential, positive regulation of proteolysis, positive regulation of release of cytochrome c from mitochondria, positive regulation of type B pancreatic cell development, regulation of apoptotic process, regulation of mitochondrial membrane permeability, release of cytochrome c from mitochondria, type B pancreatic cell proliferation; MF: cysteine-type endopeptidase activator activity, lipid binding, phospholipid binding, protein binding, protein kinase binding, protein phosphatase binding; CC: BAD-BCL-2 complex, cytoplasm, cytosol, membrane, mitochondrial outer membrane, mitochondrion
Pathways: AKT phosphorylates targets in the cytosol, Activation of BAD and translocation to mitochondria , Activation of BH3-only proteins, Acute myeloid leukemia - Homo sapiens (human), Alpha-synuclein signaling, Alpha6Beta4Integrin, Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amyotrophic lateral sclerosis (ALS), Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis Modulation and Signaling, Autophagy - animal - Homo sapiens (human), BDNF, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, Brain-derived neurotrophic factor (BDNF) signaling pathway, CXCR4-mediated signaling events, Cell death signalling via NRAGE, NRIF and NADE, Ceramide signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Chromosomal and microsatellite instability in colorectal cancer, Chronic myeloid leukemia - Homo sapiens (human), Class I PI3K signaling events mediated by Akt, Colorectal cancer - Homo sapiens (human), Constitutive Signaling by AKT1 E17K in Cancer, DNA damage response (only ATM dependent), Death Receptor Signaling, Disease, Diseases of signal transduction by growth factor receptors and second messengers, EGFR Tyrosine Kinase Inhibitor Resistance, EGFR1, Endometrial cancer, Endometrial cancer - Homo sapiens (human), ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), ErbB1 downstream signaling, ErbB2/ErbB3 signaling events, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Gastrin signaling pathway, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Host-pathogen interaction of human coronaviruses - apoptosis, Human immunodeficiency virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IGF1 pathway, IL-18 signaling pathway, IL-3 signaling pathway, IL-4 signaling pathway, IL-6 signaling pathway, IL-7, IL-7 signaling pathway, IL3, IL4, IL6, Insulin signaling pathway - Homo sapiens (human), Intracellular Signalling Through Adenosine Receptor A2a and Adenosine, Intracellular Signalling Through Adenosine Receptor A2b and Adenosine, Intracellular signaling by second messengers, Intrinsic Pathway for Apoptosis, Kit receptor signaling pathway, Leptin signaling pathway, Lipid and atherosclerosis - Homo sapiens (human), Measles - Homo sapiens (human), Melanoma, Melanoma - Homo sapiens (human), NO-cGMP-PKG mediated Neuroprotection, NRAGE signals death through JNK, Nephrin/Neph1 signaling in the kidney podocyte, Neurotrophin signaling pathway - Homo sapiens (human), Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Oxidative Damage, PI3K-AKT-mTOR signaling pathway and therapeutic opportunities, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Programmed Cell Death, Prostate cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, Ras signaling, Ras signaling pathway - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), Role of Calcineurin-dependent NFAT signaling in lymphocytes, Signal Transduction, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by Stem cell factor receptor (c-Kit), TNF-alpha signaling pathway, TWEAK, Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, Toxoplasmosis - Homo sapiens (human), Trk receptor signaling mediated by PI3K and PLC-gamma, Tuberculosis - Homo sapiens (human), VEGF signaling pathway - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), akt signaling pathway, apoptotic signaling in response to dna damage, cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human), ceramide signaling pathway, multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation, p75 NTR receptor-mediated signalling, p75(NTR)-mediated signaling, phosphoinositides and their downstream targets, ras signaling pathway, regulation of bad phosphorylation, role of nicotinic acetylcholine receptors in the regulation of apoptosis, trefoil factors initiate mucosal healing
UniProt: Q92934
Entrez ID: 572
|
Does Knockout of FAM110A in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
FAM110A
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: FAM110A (family with sequence similarity 110 member A)
Type: protein-coding
Summary: Predicted to be located in cytoplasm; microtubule organizing center; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell cortex, centrosome, cytoplasm, cytoskeleton, cytosol, nucleus, spindle microtubule, spindle pole
Pathways: IL-18 signaling pathway
UniProt: Q9BQ89
Entrez ID: 83541
|
Does Knockout of ANAPC4 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
ANAPC4
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ANAPC4 (anaphase promoting complex subunit 4)
Type: protein-coding
Summary: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition; MF: protein binding, protein phosphatase binding, ubiquitin-protein transferase activity; CC: anaphase-promoting complex, cytosol, nuclear periphery, nucleoplasm, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9UJX5
Entrez ID: 29945
|
Does Knockout of TSEN15 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
TSEN15
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TSEN15 (tRNA splicing endonuclease subunit 15)
Type: protein-coding
Summary: This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: mRNA processing, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: nucleic acid binding, protein binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of RNA, tRNA processing, tRNA processing in the nucleus, tRNA splicing
UniProt: Q8WW01
Entrez ID: 116461
|
Does Knockout of CWC25 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
CWC25
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CWC25 (CWC25 spliceosome associated protein)
Type: protein-coding
Summary: This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; CC: U2-type catalytic step 1 spliceosome, U2-type spliceosomal complex, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9NXE8
Entrez ID: 54883
|
Does Knockout of KRTAP10-2 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,391
|
Knockout
|
KRTAP10-2
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: KRTAP10-2 (keratin associated protein 10-2)
Type: protein-coding
Summary: This gene encodes a member of the high sulfur-type keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. This gene is located in a cluster of similar genes on 21q22.3. Alternatively-spliced transcript variants have been identified. [provided by RefSeq, Jan 2015].
Gene Ontology: CC: cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization, Vitamin D Receptor Pathway
UniProt: P60368
Entrez ID: 386679
|
Does Knockout of ELMOD2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
ELMOD2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: ELMOD2 (ELMO domain containing 2)
Type: protein-coding
Summary: This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: defense response to virus, regulation of defense response to virus; MF: GTPase activator activity
Pathways: Lung fibrosis
UniProt: Q8IZ81
Entrez ID: 255520
|
Does Knockout of SUPV3L1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
SUPV3L1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SUPV3L1 (Suv3 like RNA helicase)
Type: protein-coding
Summary: Enables helicase activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including mitochondrial RNA metabolic process; mitochondrion morphogenesis; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrial nucleoid and nucleus. Part of mitochondrial degradosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA recombination, RNA catabolic process, mitochondrial RNA 3'-end processing, mitochondrial RNA catabolic process, mitochondrial RNA surveillance, mitochondrial mRNA catabolic process, mitochondrial mRNA surveillance, mitochondrial ncRNA surveillance, mitochondrion organization, negative regulation of apoptotic process, positive regulation of cell growth, positive regulation of mitochondrial RNA catabolic process; MF: 3'-5' RNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding, protein homodimerization activity; CC: mitochondrial degradosome, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleus
Pathways: Metabolism of RNA, Mitochondrial RNA degradation
UniProt: Q8IYB8
Entrez ID: 6832
|
Does Knockout of NXPE1 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
NXPE1
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: NXPE1 (neurexophilin and PC-esterase domain family member 1)
Type: protein-coding
Summary: Predicted to be located in extracellular region. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8N323
Entrez ID: 120400
|
Does Knockout of LONP1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
LONP1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: LONP1 (lon peptidase 1, mitochondrial)
Type: protein-coding
Summary: This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: cellular response to oxidative stress, chaperone-mediated protein complex assembly, mitochondrial DNA metabolic process, mitochondrial protein catabolic process, mitochondrion organization, negative regulation of insulin receptor signaling pathway, oxidation-dependent protein catabolic process, protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins, protein-containing complex assembly, proteolysis, proteolysis involved in protein catabolic process, response to aluminum ion, response to hormone, response to hypoxia; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, DNA binding, DNA polymerase binding, G-quadruplex DNA binding, PH domain binding, hydrolase activity, identical protein binding, insulin receptor substrate binding, mitochondrial promoter sequence-specific DNA binding, nucleotide binding, peptidase activity, protein binding, sequence-specific DNA binding, serine-type endopeptidase activity, serine-type peptidase activity, single-stranded DNA binding, single-stranded RNA binding; CC: cytosol, membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleoplasm
Pathways: Cellular responses to stimuli, Cellular responses to stress, Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial unfolded protein response (UPRmt)
UniProt: P36776
Entrez ID: 9361
|
Does Knockout of LAS1L in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
LAS1L
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: LAS1L (LAS1 like ribosome biogenesis factor)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in membrane. Part of MLL1 complex. Implicated in Wilson-Turner syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing; MF: RNA binding, endonuclease activity, hydrolase activity, protein binding; CC: Las1 complex, MLL1 complex, cytoplasm, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y4W2
Entrez ID: 81887
|
Does Knockout of MCM3 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
MCM3
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: MCM3 (minichromosome maintenance complex component 3)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018].
Gene Ontology: BP: DNA replication, DNA replication initiation, DNA strand elongation involved in DNA replication, double-strand break repair via break-induced replication, mitotic DNA replication initiation, regulation of DNA-templated DNA replication initiation; MF: ATP binding, ATP hydrolysis activity, DNA binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: CMG complex, MCM complex, alpha DNA polymerase:primase complex, chromosome, chromosome, telomeric region, cytoplasm, membrane, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Ciliary landscape, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA strand elongation, E2F transcription factor network, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, Retinoblastoma gene in cancer, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, Unwinding of DNA, cdk regulation of dna replication
UniProt: P25205
Entrez ID: 4172
|
Does Knockout of SFRP2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
SFRP2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SFRP2 (secreted frizzled related protein 2)
Type: protein-coding
Summary: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: BMP signaling pathway, Wnt signaling pathway, Wnt signaling pathway involved in somitogenesis, anterior/posterior pattern specification, apoptotic process, branching involved in blood vessel morphogenesis, canonical Wnt signaling pathway, cardiac left ventricle morphogenesis, cardiac muscle cell apoptotic process, cartilage development, cell differentiation, cell-cell signaling, cellular response to X-ray, chondrocyte development, collagen fibril organization, convergent extension involved in axis elongation, development of primary male sexual characteristics, digestive tract morphogenesis, embryonic digit morphogenesis, hematopoietic stem cell proliferation, male gonad development, mesodermal cell fate specification, negative regulation of BMP signaling pathway, negative regulation of DNA-templated transcription, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell growth, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of dermatome development, negative regulation of epithelial cell proliferation, negative regulation of epithelial to mesenchymal transition, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of gene expression, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of mesodermal cell fate specification, negative regulation of peptidyl-tyrosine phosphorylation, neural tube closure, neural tube development, non-canonical Wnt signaling pathway, outflow tract morphogenesis, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of canonical Wnt signaling pathway, positive regulation of cell adhesion mediated by integrin, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of fat cell differentiation, positive regulation of osteoblast differentiation, positive regulation of transcription by RNA polymerase II, post-anal tail morphogenesis, regulation of Wnt signaling pathway, regulation of apoptotic process, regulation of cell growth, regulation of cell population proliferation, regulation of establishment of planar polarity, regulation of midbrain dopaminergic neuron differentiation, regulation of neuron projection development, regulation of stem cell division, response to nutrient, response to xenobiotic stimulus, sclerotome development, somitogenesis, stem cell fate specification; MF: Wnt-protein binding, endopeptidase activator activity, enzyme activator activity, fibronectin binding, integrin binding, receptor ligand activity; CC: extracellular matrix, extracellular region, extracellular space
Pathways: LncRNA involvement in canonical Wnt signaling and colorectal cancer, Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), ncRNAs involved in Wnt signaling in hepatocellular carcinoma
UniProt: Q96HF1
Entrez ID: 6423
|
Does Knockout of MIEF1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
MIEF1
|
response to virus
|
Hepatoma Cell Line
|
Gene: MIEF1 (mitochondrial elongation factor 1)
Type: protein-coding
Summary: Enables ADP binding activity; GDP binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of mitochondrial fission; positive regulation of mitochondrial translation; and positive regulation of protein targeting to membrane. Located in mitochondrial matrix and mitochondrial outer membrane. Colocalizes with mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mitochondrial fission, mitochondrial fusion, mitochondrion organization, positive regulation of mitochondrial fission, positive regulation of mitochondrial fusion, positive regulation of protein targeting to membrane; MF: ADP binding, GDP binding, identical protein binding, nucleotide binding, protein binding; CC: membrane, mitochondrial outer membrane, mitochondrion, peroxisome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Translation
UniProt: Q9NQG6
Entrez ID: 54471
|
Does Knockout of FAM217B in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
FAM217B
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: FAM217B (family with sequence similarity 217 member B)
Type: protein-coding
Summary: Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, nucleoplasm
Pathways:
UniProt: Q9NTX9
Entrez ID: 63939
|
Does Knockout of PAOX in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
PAOX
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: PAOX (polyamine oxidase)
Type: protein-coding
Summary: Enables polyamine oxidase activity. Involved in polyamine metabolic process and positive regulation of spermidine biosynthetic process. Predicted to be located in cytosol and peroxisomal matrix. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: polyamine catabolic process, positive regulation of spermidine biosynthetic process, putrescine biosynthetic process, putrescine catabolic process, spermidine catabolic process, spermine catabolic process, spermine metabolic process; MF: N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity, oxidoreductase activity, polyamine oxidase activity; CC: cytoplasm, cytosol, peroxisomal matrix, peroxisome
Pathways: Alpha9 beta1 integrin signaling events, Amine Oxidase reactions, Biological oxidations, Interconversion of polyamines, Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, PAOs oxidise polyamines to amines, Peroxisomal protein import, Peroxisome - Homo sapiens (human), Phase I - Functionalization of compounds, Protein localization, spermine and spermidine degradation I
UniProt: Q6QHF9
Entrez ID: 196743
|
Does Knockout of C11orf40 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
C11orf40
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: C11orf40 (chromosome 11 putative open reading frame 40)
Type: ncRNA
Summary: chromosome 11 putative open reading frame 40
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 143501
|
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