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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of DNAJC17 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
DNAJC17
|
cell proliferation
|
Melanoma Cell Line
|
Gene: DNAJC17 (DnaJ heat shock protein family (Hsp40) member C17)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and toxin transport. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, spliceosomal complex disassembly; MF: RNA binding, nucleic acid binding, protein binding; CC: cytoplasm, nucleus, spliceosomal complex
Pathways:
UniProt: Q9NVM6
Entrez ID: 55192
|
Does Knockout of CCP110 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
CCP110
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CCP110 (centriolar coiled-coil protein 110)
Type: protein-coding
Summary: Involved in centriole replication; negative regulation of cilium assembly; and regulation of cytokinesis. Located in centriole and centrosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell projection organization, centriole replication, centrosome duplication, ciliary basal body organization, negative regulation of cilium assembly, positive regulation of cilium assembly, regulation of cytokinesis; CC: cell projection, centriole, centrosome, cilium, cytoplasm, cytoskeleton, cytosol, microtubule organizing center, protein-containing complex
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, Deubiquitination, G2/M Transition, Genotoxicity pathway, Joubert Syndrome, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Post-translational protein modification, RHO GTPase cycle, RHOV GTPase cycle, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Ub-specific processing proteases
UniProt: O43303
Entrez ID: 9738
|
Does Knockout of RPL23 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
RPL23
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: RPL23 (ribosomal protein L23)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G1 to G0 transition, cellular response to actinomycin D, cytoplasmic translation, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin protein ligase activity, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of signal transduction by p53 class mediator, protein stabilization, protein-DNA complex disassembly, regulation of G1 to G0 transition, ribosomal protein import into nucleus, translation; MF: RNA binding, large ribosomal subunit rRNA binding, protein binding, structural constituent of ribosome, transcription coactivator binding, ubiquitin ligase inhibitor activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, large ribosomal subunit, membrane, nucleolus, nucleoplasm, protein-containing complex, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, p53 pathway, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62829
Entrez ID: 9349
|
Does Knockout of ATRIP in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
ATRIP
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: ATRIP (ATR interacting protein)
Type: protein-coding
Summary: This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, nucleobase-containing compound metabolic process, regulation of double-strand break repair; MF: K63-linked polyubiquitin modification-dependent protein binding, protein binding; CC: ATR-ATRIP complex, nucleoplasm, nucleus
Pathways: ATR Signaling, ATR signaling pathway, Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, DNA damage response, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Fanconi Anemia Pathway, Fanconi anemia pathway, Fanconi anemia pathway - Homo sapiens (human), G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Impaired BRCA2 binding to RAD51, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53, miRNA regulation of DNA damage response
UniProt: Q8WXE1
Entrez ID: 84126
|
Does Knockout of ILF3 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
ILF3
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: ILF3 (interleukin enhancer binding factor 3)
Type: protein-coding
Summary: This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014].
Gene Ontology: BP: defense response to virus, negative regulation of DNA-templated transcription, negative regulation of translation, negative regulation of viral genome replication, positive regulation of DNA-templated transcription, protein phosphorylation, spliceosome-depend formation of circular RNA, symbiont entry into host cell; MF: DNA binding, RNA binding, double-stranded RNA binding, mRNA 3'-UTR AU-rich region binding, protein binding, single-stranded RNA binding, virus receptor activity; CC: cytoplasm, cytosol, extracellular region, membrane, mitochondrion, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Adherens junctions interactions, Antiviral mechanism by IFN-stimulated genes, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cytokine Signaling in Immune system, Immune System, Interferon Signaling, PKR-mediated signaling, Regulation of CDH11 Expression and Function, Regulation of CDH11 gene transcription, Regulation of Expression and Function of Type II Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q12906
Entrez ID: 3609
|
Does Knockout of RPL21 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
RPL21
|
response to virus
|
Hepatoma Cell Line
|
Gene: RPL21 (ribosomal protein L21)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, membrane, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46778
Entrez ID: 6144
|
Does Knockout of CDC42EP3 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
CDC42EP3
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: CDC42EP3 (CDC42 effector protein 3)
Type: protein-coding
Summary: This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: Rho protein signal transduction, positive regulation of actin filament polymerization, positive regulation of pseudopodium assembly, regulation of cell shape, signal transduction; MF: cytoskeletal regulatory protein binding, protein binding, small GTPase binding; CC: actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, endomembrane system, membrane, plasma membrane
Pathways: CDC42 GTPase cycle, Glucocorticoid Receptor Pathway, MAPK family signaling cascades, MAPK6/MAPK4 signaling, Nuclear Receptors Meta-Pathway, RHO GTPase cycle, RHOQ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9UKI2
Entrez ID: 10602
|
Does Knockout of STXBP2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
STXBP2
|
cell proliferation
|
Cancer Cell Line
|
Gene: STXBP2 (syntaxin binding protein 2)
Type: protein-coding
Summary: This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: cellular response to type II interferon, exocytosis, intracellular protein transport, leukocyte mediated cytotoxicity, neutrophil degranulation, presynaptic dense core vesicle exocytosis, protein transport, regulated exocytosis, regulation of mast cell degranulation, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: protein binding, syntaxin binding, syntaxin-1 binding, syntaxin-3 binding; CC: apical plasma membrane, azurophil granule, cytolytic granule, cytosol, extracellular exosome, extracellular region, phagocytic vesicle, plasma membrane, presynapse, secretory granule, specific granule, tertiary granule, zymogen granule membrane
Pathways: Cytokine Signaling in Immune system, Hemostasis, Immune System, Insulin Signaling, Other interleukin signaling, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, Signaling by Interleukins, Splicing factor NOVA regulated synaptic proteins
UniProt: Q15833
Entrez ID: 6813
|
Does Knockout of HOXB6 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
HOXB6
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: HOXB6 (homeobox B6)
Type: protein-coding
Summary: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anterior/posterior pattern specification, embryonic skeletal system development, embryonic skeletal system morphogenesis, erythrocyte homeostasis, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: P17509
Entrez ID: 3216
|
Does Knockout of GTF2H4 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
GTF2H4
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: GTF2H4 (general transcription factor IIH subunit 4)
Type: protein-coding
Summary: Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, nucleotide-excision repair, transcription by RNA polymerase II; MF: ATPase activator activity, RNA polymerase II general transcription initiation factor activity, double-stranded DNA binding, protein binding; CC: core TFIIH complex portion of holo TFIIH complex, nuclear speck, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: AndrogenReceptor, Basal transcription factors - Homo sapiens (human), DNA Repair, DNA Repair Pathways Full Network, Disease, Dual Incision in GG-NER, Dual incision in TC-NER, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), mRNA Capping
UniProt: Q92759
Entrez ID: 2968
|
Does Knockout of PSMC1 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
PSMC1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: PSMC1 (proteasome 26S subunit, ATPase 1)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: positive regulation of proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATP binding, ATP hydrolysis activity, RNA binding, nucleotide binding, proteasome-activating activity, protein binding; CC: cytoplasm, cytosol, membrane, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, base subcomplex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Asparagine N-linked glycosylation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Human papillomavirus infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P62191
Entrez ID: 5700
|
Does Knockout of FFAR3 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
FFAR3
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: FFAR3 (free fatty acid receptor 3)
Type: protein-coding
Summary: Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and cellular response to fatty acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cellular response to fatty acid, immune system process, inflammatory response, mucosal immune response, negative regulation of blood pressure, positive regulation of acute inflammatory response to non-antigenic stimulus, positive regulation of chemokine production, positive regulation of cytokine production involved in immune response, regulation of hormone biosynthetic process, regulation of insulin receptor signaling pathway, regulation of norepinephrine secretion, regulation of peptide hormone secretion, signal transduction; MF: G protein-coupled receptor activity, lipid binding, protein binding; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Free fatty acid receptors, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, SCFA and skeletal muscle substrate metabolism, Signal Transduction, Signaling by GPCR
UniProt: O14843
Entrez ID: 2865
|
Does Knockout of SFPQ in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
SFPQ
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: SFPQ (splicing factor proline and glutamine rich)
Type: protein-coding
Summary: Enables DNA binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within double-strand break repair via homologous recombination. Located in chromatin; nuclear matrix; and paraspeckles. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, RNA splicing, activation of innate immune response, alternative mRNA splicing, via spliceosome, chromatin remodeling, chromosome organization, dendritic transport of messenger ribonucleoprotein complex, double-strand break repair via homologous recombination, immune system process, innate immune response, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of circadian rhythm, negative regulation of transcription by RNA polymerase II, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of sister chromatid cohesion, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of circadian rhythm, rhythmic process; MF: DNA binding, RNA binding, chromatin binding, histone deacetylase binding, nucleic acid binding, protein binding, protein homodimerization activity, transcription cis-regulatory region binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, cytosol, dendrite, nuclear matrix, nuclear speck, nucleoplasm, nucleus, paraspeckles
Pathways: Bacterial Infection Pathways, Disease, EGFR1, Infection with Mycobacterium tuberculosis, Infectious disease, PTK6 Regulates Proteins Involved in RNA Processing, Response of Mtb to phagocytosis, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Suppression of apoptosis, Type 2 papillary renal cell carcinoma, antisense pathway, mRNA Processing
UniProt: P23246
Entrez ID: 6421
|
Does Knockout of SOCS1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
SOCS1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SOCS1 (suppressor of cytokine signaling 1)
Type: protein-coding
Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, cellular response to amino acid stimulus, cytokine-mediated signaling pathway, developmental process, fat cell differentiation, intracellular signal transduction, macrophage differentiation, negative regulation of CD8-positive, alpha-beta T cell differentiation, negative regulation of insulin receptor signaling pathway, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of signal transduction, positive regulation of CD4-positive, alpha-beta T cell differentiation, positive regulation of regulatory T cell differentiation, protein ubiquitination, regulation of cytokine production, regulation of receptor signaling pathway via JAK-STAT; MF: cytokine receptor binding, insulin-like growth factor receptor binding, kinase inhibitor activity, protein binding, protein kinase binding, protein kinase inhibitor activity; CC: cytoplasm, cytoplasmic vesicle, cytosol, nucleoplasm, nucleus
Pathways: Acute viral myocarditis, Adaptive Immune System, Adipogenesis, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, EGFR1, EPO Receptor Signaling, Growth hormone receptor signaling, Growth hormone synthesis, secretion and action - Homo sapiens (human), IFN-gamma pathway, IL-4 signaling pathway, IL12-mediated signaling events, IL2-mediated signaling events, IL4, IL4-mediated signaling events, IL5, Immune System, Immune response to tuberculosis, Inactivation of CSF3 (G-CSF) signaling, Innate Immune System, Insulin Signaling, Insulin signaling pathway - Homo sapiens (human), Interactions between immune cells and microRNAs in tumor microenvironment, Interferon Signaling, Interferon alpha/beta signaling, Interferon gamma signaling, Interferon type I signaling pathways, Interleukin-4 and Interleukin-13 signaling, Interleukin-7 signaling, JAK-STAT signaling pathway - Homo sapiens (human), Kit receptor signaling pathway, KitReceptor, Leptin Insulin Overlap, MicroRNAs in cancer - Homo sapiens (human), Modulators of TCR signaling and T cell activation, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Osteoclast differentiation - Homo sapiens (human), Prolactin, Prolactin Signaling Pathway, Prolactin signaling pathway - Homo sapiens (human), Regulation of IFNA/IFNB signaling, Regulation of IFNG signaling, Regulation of KIT signaling, Regulation of toll-like receptor signaling pathway, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling events mediated by Stem cell factor receptor (c-Kit), Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toxoplasmosis - Homo sapiens (human), Type II diabetes mellitus - Homo sapiens (human), Type II interferon signaling (IFNG), Ubiquitin mediated proteolysis - Homo sapiens (human), il-2 receptor beta chain in t cell activation
UniProt: O15524
Entrez ID: 8651
|
Does Knockout of BDH2 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
BDH2
|
response to virus
|
Huh-7 Cell
|
Gene: BDH2 (3-hydroxybutyrate dehydrogenase 2)
Type: protein-coding
Summary: Enables 3-hydroxybutyrate dehydrogenase activity and NAD binding activity. Involved in epithelial cell differentiation and fatty acid beta-oxidation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epithelial cell differentiation, fatty acid beta-oxidation, heme metabolic process, lipid metabolic process, siderophore biosynthetic process; MF: 3-hydroxybutyrate dehydrogenase activity, 4-oxoproline reductase activity, NAD binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor, protein binding; CC: cytoplasm, cytosol, extracellular exosome, mitochondrion
Pathways: Butanoate metabolism - Homo sapiens (human), Ketone body metabolism, Metabolism, Metabolism of lipids, Synthesis and degradation of ketone bodies - Homo sapiens (human), Synthesis of Ketone Bodies, ketogenesis, ketolysis
UniProt: Q9BUT1
Entrez ID: 56898
|
Does Knockout of RRP7A in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
RRP7A
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: RRP7A (ribosomal RNA processing 7 homolog A)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to act upstream of or within blastocyst formation. Predicted to be located in nucleoplasm. Predicted to be part of CURI complex and UTP-C complex. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: blastocyst formation, cilium disassembly, protein localization to nucleolus, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, nucleic acid binding, protein binding; CC: CURI complex, UTP-C complex, cell junction, cell projection, centrosome, cilium, cytoplasm, cytoskeleton, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y3A4
Entrez ID: 27341
|
Does Knockout of CARS2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
CARS2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017].
Gene Ontology: BP: cysteinyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, cysteine-tRNA ligase activity, ligase activity, metal ion binding, nucleotide binding; CC: cytoplasm, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Metabolism of proteins, Mitochondrial tRNA aminoacylation, Translation, tRNA Aminoacylation, tRNA charging
UniProt: Q9HA77
Entrez ID: 79587
|
Does Knockout of RPS9 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
RPS9
|
cell proliferation
|
Bladder Carcinoma
|
Gene: RPS9 (ribosomal protein S9)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, ribosomal small subunit biogenesis, translation; MF: RNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46781
Entrez ID: 6203
|
Does Knockout of SORL1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
SORL1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: SORL1 (sortilin related receptor 1)
Type: protein-coding
Summary: This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: adaptive thermogenesis, amyloid-beta formation, cell migration, diet induced thermogenesis, endocytosis, endosome to plasma membrane protein transport, insulin receptor recycling, negative regulation of BMP signaling pathway, negative regulation of amyloid precursor protein catabolic process, negative regulation of amyloid-beta formation, negative regulation of neurofibrillary tangle assembly, negative regulation of neurogenesis, negative regulation of protein-containing complex assembly, negative regulation of triglyceride catabolic process, neuropeptide signaling pathway, positive regulation of ER to Golgi vesicle-mediated transport, positive regulation of adipose tissue development, positive regulation of early endosome to recycling endosome transport, positive regulation of endocytic recycling, positive regulation of glial cell-derived neurotrophic factor production, positive regulation of insulin receptor signaling pathway, positive regulation of protein catabolic process, positive regulation of protein exit from endoplasmic reticulum, positive regulation of protein localization to early endosome, post-Golgi vesicle-mediated transport, protein localization to Golgi apparatus, protein retention in Golgi apparatus, protein targeting, protein targeting to lysosome, receptor-mediated endocytosis, regulation of smooth muscle cell migration, retrograde transport, endosome to Golgi; MF: amyloid-beta binding, aspartic-type endopeptidase inhibitor activity, low-density lipoprotein particle binding, low-density lipoprotein particle receptor activity, neuropeptide binding, protein binding, protein transporter activity, small GTPase binding, transmembrane signaling receptor activity; CC: Golgi apparatus, Golgi cisterna, Golgi membrane, cell surface, cytoplasmic vesicle, cytosol, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, extracellular exosome, extracellular region, extracellular space, membrane, multivesicular body, multivesicular body membrane, neuronal cell body, nuclear envelope lumen, perinucleolar compartment, plasma membrane, recycling endosome, recycling endosome membrane, trans-Golgi network, transport vesicle membrane
Pathways:
UniProt: Q92673
Entrez ID: 6653
|
Does Knockout of INTS8 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
INTS8
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: INTS8 (integrator complex subunit 8)
Type: protein-coding
Summary: This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, protein localization to chromatin, regulation of transcription elongation by RNA polymerase II, snRNA 3'-end processing, snRNA processing; CC: INTAC complex, chromatin, chromosome, integrator complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q75QN2
Entrez ID: 55656
|
Does Knockout of UNG in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
UNG
|
cell proliferation
|
Cancer Cell Line
|
Gene: UNG (uracil DNA glycosylase)
Type: protein-coding
Summary: This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair, base-excision repair, AP site formation via deaminated base removal, depyrimidination, isotype switching, negative regulation of apoptotic process, single strand break repair, somatic hypermutation of immunoglobulin genes, somatic recombination of immunoglobulin gene segments; MF: damaged DNA binding, hydrolase activity, hydrolase activity, hydrolyzing N-glycosyl compounds, protein binding, ribosomal small subunit binding, uracil DNA N-glycosylase activity; CC: mitochondrion, nucleoplasm, nucleus
Pathways: Base Excision Repair, Base excision repair - Homo sapiens (human), DNA Repair Pathways Full Network, Primary immunodeficiency - Homo sapiens (human)
UniProt: P13051
Entrez ID: 7374
|
Does Knockout of PGAM1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
PGAM1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PGAM1 (phosphoglycerate mutase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: canonical glycolysis, gluconeogenesis, glycolytic process; MF: bisphosphoglycerate mutase activity, catalytic activity, hydrolase activity, intramolecular phosphotransferase activity, isomerase activity, phosphoglycerate mutase activity, protein binding, protein kinase binding; CC: cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, secretory granule lumen
Pathways: Central carbon metabolism in cancer - Homo sapiens (human), Cori Cycle, EGFR1, Fanconi-bickel syndrome, Fructose-1,6-diphosphatase deficiency, Glucagon signaling pathway - Homo sapiens (human), Gluconeogenesis, Glucose metabolism, Glycine, serine and threonine metabolism - Homo sapiens (human), Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycogenosis, Type VII. Tarui disease, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, Immune System, Innate Immune System, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Rapoport-Luebering glycolytic shunt, TCR, Triosephosphate isomerase, gluconeogenesis, glycolysis, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P18669
Entrez ID: 5223
|
Does Knockout of CMC1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
CMC1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CMC1 (C-X9-C motif containing 1)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Mitochondrial CIV Assembly, Respiratory electron transport
UniProt: Q7Z7K0
Entrez ID: 152100
|
Does Knockout of MAT2A in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
MAT2A
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: MAT2A (methionine adenosyltransferase 2A)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: S-adenosylmethionine biosynthetic process, TORC1 signaling, cellular response to amino acid starvation, cellular response to leukemia inhibitory factor, cellular response to methionine, cellular response to nutrient levels, negative regulation of TORC1 signaling, one-carbon metabolic process, positive regulation of TORC1 signaling, protein complex oligomerization, protein heterooligomerization, protein hexamerization, protein localization to lysosome, protein-containing complex localization; MF: ATP binding, identical protein binding, metal ion binding, methionine adenosyltransferase activity, nucleotide binding, protein binding, small molecule binding, transferase activity; CC: cytosol, methionine adenosyltransferase complex
Pathways: Betaine Metabolism, Biological oxidations, C-MYB transcription factor network, Cystathionine Beta-Synthase Deficiency, Cysteine and methionine metabolism - Homo sapiens (human), Glycine N-methyltransferase Deficiency, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, Metabolism, Methionine Adenosyltransferase Deficiency, Methionine De Novo and Salvage Pathway, Methionine Metabolism, Methylation, Methylation Pathways, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), One-carbon metabolism and related pathways, Phase II - Conjugation of compounds, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, S-adenosyl-L-methionine biosynthesis, Selenoamino Acid Metabolism, Spermidine and Spermine Biosynthesis, Trans-sulfuration and one-carbon metabolism, cysteine biosynthesis, methionine degradation, sarcosine oncometabolite pathway , superpathway of methionine degradation
UniProt: P31153
Entrez ID: 4144
|
Does Knockout of ALG14 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
ALG14
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ALG14 (ALG14 UDP-N-acetylglucosaminyltransferase subunit)
Type: protein-coding
Summary: This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation; MF: protein binding, protein-membrane adaptor activity; CC: UDP-N-acetylglucosamine transferase complex, cytoplasmic side of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective ALG14 causes ALG14-CMS, Disease, Diseases associated with N-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Glycosylation and related congenital defects, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), Post-translational protein modification, Various types of N-glycan biosynthesis - Homo sapiens (human)
UniProt: Q96F25
Entrez ID: 199857
|
Does Knockout of PLAC8 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
PLAC8
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PLAC8 (placenta associated 8)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including brown fat cell differentiation; defense response to bacterium; and response to cold. Predicted to be located in azurophil granule lumen and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: brown fat cell differentiation, defense response to bacterium, negative regulation of apoptotic process, negative regulation of multicellular organism growth, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of transcription by RNA polymerase II, response to cold, transcription by RNA polymerase II; CC: azurophil granule lumen, extracellular region
Pathways: Developmental Biology, Differentiation of white and brown adipocyte, Formation of the nephric duct, Gastric Cancer Network 2, Immune System, Innate Immune System, Kidney development, Neutrophil degranulation
UniProt: Q9NZF1
Entrez ID: 51316
|
Does Knockout of CPSF3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
CPSF3
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CPSF3 (cleavage and polyadenylation specific factor 3)
Type: protein-coding
Summary: This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, positive regulation of G1/S transition of mitotic cell cycle; MF: 5'-3' RNA exonuclease activity, RNA binding, RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, protein binding; CC: mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human), polyadenylation of mrna
UniProt: Q9UKF6
Entrez ID: 51692
|
Does Knockout of SLC10A2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
SLC10A2
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: SLC10A2 (solute carrier family 10 member 2)
Type: protein-coding
Summary: This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010].
Gene Ontology: BP: bile acid and bile salt transport, lipid transport, monoatomic ion transport, response to bacterium, sodium ion transport, transmembrane transport; MF: bile acid:sodium symporter activity, protein binding, symporter activity; CC: apical plasma membrane, membrane, microvillus, plasma membrane
Pathways: Bile acid and bile salt metabolism, Bile secretion - Homo sapiens (human), Metabolism, Metabolism of lipids, Metabolism of steroids, Recycling of bile acids and salts
UniProt: Q12908
Entrez ID: 6555
|
Does Knockout of TRIP6 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
TRIP6
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: TRIP6 (thyroid hormone receptor interactor 6)
Type: protein-coding
Summary: This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, chordate embryonic development, focal adhesion assembly, positive regulation of cell migration, positive regulation of non-canonical NF-kappaB signal transduction, signal transduction; MF: RNA binding, interleukin-1 receptor binding, kinase binding, metal ion binding, nuclear thyroid hormone receptor binding, protein binding; CC: anchoring junction, cytoplasm, cytoskeleton, cytosol, focal adhesion, nucleus, plasma membrane, stress fiber
Pathways: AP-1 transcription factor network, EGFR1, LPA receptor mediated events, NOD-like receptor signaling pathway - Homo sapiens (human)
UniProt: Q15654
Entrez ID: 7205
|
Does Activation of LCE3E in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
LCE3E
|
response to virus
|
Hepatoma Cell Line
|
Gene: LCE3E (late cornified envelope 3E)
Type: protein-coding
Summary: Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epidermis development, keratinization
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q5T5B0
Entrez ID: 353145
|
Does Knockout of SMPDL3B in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
SMPDL3B
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: SMPDL3B (sphingomyelin phosphodiesterase acid like 3B)
Type: protein-coding
Summary: Enables phosphoric diester hydrolase activity. Predicted to be involved in membrane lipid catabolic process; negative regulation of inflammatory response; and negative regulation of toll-like receptor signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: immune system process, inflammatory response, innate immune response, lipid catabolic process, lipid metabolic process, membrane lipid catabolic process, negative regulation of inflammatory response, negative regulation of toll-like receptor signaling pathway, sphingomyelin catabolic process; MF: hydrolase activity, hydrolase activity, acting on glycosyl bonds, metal ion binding, phosphoric diester hydrolase activity, protein binding, sphingomyelin phosphodiesterase activity, zinc ion binding; CC: extracellular exosome, extracellular region, extracellular space, membrane, plasma membrane, side of membrane
Pathways:
UniProt: Q92485
Entrez ID: 27293
|
Does Knockout of RPS21 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
RPS21
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: RPS21 (ribosomal protein S21)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, nucleoplasm, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P63220
Entrez ID: 6227
|
Does Knockout of ALKBH4 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
ALKBH4
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: ALKBH4 (alkB homolog 4, lysine demethylase)
Type: protein-coding
Summary: Enables 2-oxoglutarate-dependent dioxygenase activity and actin binding activity. Involved in actomyosin structure organization; cleavage furrow ingression; and protein demethylation. Located in contractile ring and midbody. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actomyosin structure organization, chromatin organization, cleavage furrow ingression, demethylation, positive regulation of gene expression, epigenetic; MF: 2-oxoglutarate-dependent dioxygenase activity, DNA N6-methyladenine demethylase activity, actin binding, broad specificity oxidative DNA demethylase activity, demethylase activity, dioxygenase activity, metal ion binding, oxidoreductase activity, protein binding, protein demethylase activity; CC: contractile ring, cytoplasm, midbody, nucleolus, nucleus
Pathways:
UniProt: Q9NXW9
Entrez ID: 54784
|
Does Knockout of EIF3B in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
EIF3B
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: EIF3B (eukaryotic translation initiation factor 3 subunit B)
Type: protein-coding
Summary: Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and viral translational termination-reinitiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: IRES-dependent viral translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, regulation of translational initiation, translation, translational initiation, viral translational termination-reinitiation; MF: RNA binding, molecular adaptor activity, nucleic acid binding, protein binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, extracellular exosome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, IL2, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: P55884
Entrez ID: 8662
|
Does Knockout of NELFB in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
NELFB
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: NELFB (negative elongation factor complex member B)
Type: protein-coding
Summary: NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell population proliferation, negative regulation of DNA-templated transcription, negative regulation of stem cell differentiation, negative regulation of transcription elongation by RNA polymerase II, stem cell differentiation; MF: RNA binding, protein binding; CC: NELF complex, cytoplasm, nucleoplasm, nucleus
Pathways: Initiation of transcription and translation elongation at the HIV-1 LTR
UniProt: Q8WX92
Entrez ID: 25920
|
Does Knockout of ILK in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
ILK
|
cell proliferation
|
Cancer Cell Line
|
Gene: ILK (integrin linked kinase)
Type: protein-coding
Summary: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: Schwann cell development, anatomical structure morphogenesis, branching involved in ureteric bud morphogenesis, caveola assembly, cell differentiation, cell morphogenesis, cell population proliferation, cell projection organization, cell-matrix adhesion, establishment or maintenance of epithelial cell apical/basal polarity, fibroblast migration, integrin-mediated signaling pathway, mitotic spindle organization, myelination in peripheral nervous system, negative regulation of neural precursor cell proliferation, nerve development, neural precursor cell proliferation, outflow tract morphogenesis, phosphatidylinositol 3-kinase/protein kinase B signal transduction, platelet aggregation, positive regulation of BMP signaling pathway, positive regulation of DNA-templated transcription, positive regulation of canonical NF-kappaB signal transduction, positive regulation of canonical Wnt signaling pathway, positive regulation of cell population proliferation, positive regulation of osteoblast differentiation, positive regulation of signal transduction, positive regulation of substrate adhesion-dependent cell spreading, protein localization to cell cortex, substrate adhesion-dependent cell spreading, tumor necrosis factor-mediated signaling pathway; MF: ATP binding, integrin binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein-macromolecule adaptor activity, signaling receptor binding; CC: actin cytoskeleton, anchoring junction, cell cortex, cell projection, centrosome, chromatin, cytoplasm, cytoskeleton, cytosol, focal adhesion, lamellipodium, membrane, nucleoplasm, nucleus, plasma membrane, sarcomere
Pathways: Acute viral myocarditis, Axon guidance - Homo sapiens (human), Bacterial invasion of epithelial cells - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions, Development of ureteric collection system, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Eukaryotic Transcription Initiation, Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Focal Adhesion, Focal adhesion - Homo sapiens (human), Genes controlling nephrogenesis, Integrin-linked kinase signaling, Integrin-mediated Cell Adhesion, Integrins in angiogenesis, Localization of the PINCH-ILK-PARVIN complex to focal adhesions, Osteopontin-mediated events, PPAR signaling pathway, PPAR signaling pathway - Homo sapiens (human), Primary focal segmental glomerulosclerosis (FSGS), Shigellosis - Homo sapiens (human), Wnt, pten dependent cell cycle arrest and apoptosis
UniProt: Q13418
Entrez ID: 3611
|
Does Knockout of MYBPHL in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
MYBPHL
|
response to virus
|
Hepatoma Cell Line
|
Gene: MYBPHL (myosin binding protein H like)
Type: protein-coding
Summary: This gene encodes a protein with two immunoglobulin superfamily domains and a fibronectin 3 domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012].
Gene Ontology: BP: biological_process, in utero embryonic development; MF: molecular_function, protein binding; CC: cytoplasm, myofilament, sarcomere
Pathways:
UniProt: A2RUH7
Entrez ID: 343263
|
Does Knockout of RPL8 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
RPL8
|
cell proliferation
|
Cancer Cell Line
|
Gene: RPL8 (ribosomal protein L8)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, focal adhesion, large ribosomal subunit, membrane, nucleoplasm, postsynapse, postsynaptic density, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Post-translational protein modification, Protein hydroxylation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, TNFalpha, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62917
Entrez ID: 6132
|
Does Knockout of WDR77 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
WDR77
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: WDR77 (WD repeat domain 77)
Type: protein-coding
Summary: The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: epithelial cell proliferation involved in prostate gland development, negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation involved in prostate gland development, oocyte axis specification, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of mRNA splicing, via spliceosome, protein polyubiquitination, regulation of transcription by RNA polymerase II, secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development, spliceosomal snRNP assembly, ubiquitin-dependent protein catabolic process; MF: methyl-CpG binding, protein binding, transcription coactivator activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul4B-RING E3 ubiquitin ligase complex, Golgi apparatus, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, transferase complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Metabolism of RNA, Metabolism of non-coding RNA, RMTs methylate histone arginines, Signaling events mediated by HDAC Class I, snRNP Assembly
UniProt: Q9BQA1
Entrez ID: 79084
|
Does Knockout of GTF2H1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
GTF2H1
|
cell proliferation
|
Cancer Cell Line
|
Gene: GTF2H1 (general transcription factor IIH subunit 1)
Type: protein-coding
Summary: Enables thyroid hormone receptor binding activity. Involved in positive regulation of transcription, DNA-templated and transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, hormone-mediated signaling pathway, nucleotide-excision repair, positive regulation of DNA-templated transcription, regulation of cyclin-dependent protein serine/threonine kinase activity, transcription by RNA polymerase I, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: chromatin binding, nuclear thyroid hormone receptor binding, protein binding; CC: nucleoplasm, nucleus, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: AndrogenReceptor, Basal transcription factors - Homo sapiens (human), DNA Repair, DNA Repair Pathways Full Network, Disease, Dual Incision in GG-NER, Dual incision in TC-NER, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), mRNA Capping
UniProt: P32780
Entrez ID: 2965
|
Does Knockout of RAB1A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
RAB1A
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: RAB1A (RAB1A, member RAS oncogene family)
Type: protein-coding
Summary: This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: COPII-coated vesicle cargo loading, Golgi organization, autophagosome assembly, autophagy, cell migration, cilium assembly, defense response to bacterium, endocytosis, endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of endothelial intestinal barrier, growth hormone secretion, intracellular protein transport, melanosome transport, positive regulation of glycoprotein metabolic process, positive regulation of interleukin-8 production, protein transport, substrate adhesion-dependent cell spreading, vesicle transport along microtubule, vesicle-mediated transport, virion assembly; MF: G protein activity, GTP binding, GTPase activity, cadherin binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, early endosome, endomembrane system, endoplasmic reticulum, endosome, extracellular exosome, melanosome, membrane, transport vesicle membrane
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, Autophagy - animal - Homo sapiens (human), COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, COPII-mediated vesicle transport, Cell Cycle, Cell Cycle, Mitotic, ER to Golgi Anterograde Transport, Golgi Cisternae Pericentriolar Stack Reorganization, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Legionellosis - Homo sapiens (human), M Phase, Membrane Trafficking, Metabolism of proteins, Mitotic Prophase, PLK1 signaling events, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P62820
Entrez ID: 5861
|
Does Knockout of C12orf76 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
C12orf76
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: C12orf76 (chromosome 12 open reading frame 76)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: A0A494C145, A0A087WX00
Entrez ID: 400073
|
Does Knockout of MRPS6 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
MRPS6
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MRPS6 (mitochondrial ribosomal protein S6)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: protein binding, rRNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: P82932
Entrez ID: 64968
|
Does Knockout of CEP128 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
CEP128
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: CEP128 (centrosomal protein 128)
Type: protein-coding
Summary: Involved in protein localization. Located in centriole and spindle pole. Part of centriolar subdistal appendage. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intracellular protein localization, regulation of gene expression, sperm flagellum assembly, spermatogenesis; CC: Golgi apparatus, centriolar subdistal appendage, centriole, centrosome, cytoplasm, cytoskeleton, nuclear membrane, spindle pole
Pathways:
UniProt: Q6ZU80
Entrez ID: 145508
|
Does Knockout of NPY in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
NPY
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: NPY (neuropeptide Y)
Type: protein-coding
Summary: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adult feeding behavior, antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, central nervous system neuron development, cerebral cortex development, chemical synaptic transmission, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, feeding behavior, innate immune response, intestinal epithelial cell differentiation, monocyte activation, negative regulation of acute inflammatory response to antigenic stimulus, negative regulation of blood pressure, neuron projection development, neuropeptide signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of appetite, positive regulation of cell population proliferation, positive regulation of cell-substrate adhesion, positive regulation of dopamine metabolic process, positive regulation of eating behavior, positive regulation of nitric oxide metabolic process, regulation of blood pressure, regulation of nerve growth factor production, regulation of presynaptic cytosolic calcium ion concentration, regulation of synaptic vesicle exocytosis, response to yeast, short-day photoperiodism, synaptic signaling via neuropeptide; MF: G protein-coupled receptor activity, G protein-coupled receptor binding, calcium channel regulator activity, hormone activity, neuropeptide Y receptor binding, neuropeptide hormone activity, protein binding, signaling receptor binding; CC: GABA-ergic synapse, Golgi apparatus, cytoplasm, cytoplasmic vesicle, extracellular region, extracellular space, neuronal dense core vesicle, perikaryon, perinuclear region of cytoplasm, terminal bouton
Pathways: Adipocytokine signaling pathway - Homo sapiens (human), Alcoholism - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Endothelin Pathways, FOXO-mediated transcription, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Gene expression (Transcription), Generic Transcription Pathway, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide ligand-binding receptors, RNA Polymerase II Transcription, Regulation of lipolysis in adipocytes - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Thyroid hormones production and their peripheral downstream signaling effects, cAMP signaling pathway - Homo sapiens (human)
UniProt: P01303
Entrez ID: 4852
|
Does Knockout of DIAPH3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
DIAPH3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: DIAPH3 (diaphanous related formin 3)
Type: protein-coding
Summary: This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: actin crosslink formation, actin cytoskeleton organization, actin filament bundle assembly, actin filament organization, actin filament polymerization, actin nucleation, autophagosome-lysosome fusion, cell projection organization, chromosome segregation, cytoskeleton organization, endosomal transport, erythrocyte differentiation, erythrocyte enucleation, establishment of cell polarity, gene expression, head development, in utero embryonic development, inner ear receptor cell differentiation, integrin-mediated signaling pathway, macrophage differentiation, microtubule cytoskeleton organization, microtubule polymerization, negative regulation of microtubule depolymerization, neuron differentiation, podosome assembly, protein-containing complex remodeling, sensory perception of sound; MF: actin binding, cadherin binding, cytoskeletal protein binding, microtubule binding, protein homodimerization activity, small GTPase binding; CC: ESCRT I complex, actin filament, actin filament bundle, cleavage furrow, cytoplasm, cytosol, filamentous actin, microtubule organizing center, nucleus, ribbon synapse, spindle pole, stereocilia tip-link density
Pathways: CDC42 GTPase cycle, CDC42 signaling events, ErbB1 downstream signaling, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9NSV4
Entrez ID: 81624
|
Does Knockout of IMP4 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
IMP4
|
cell proliferation
|
Bladder Carcinoma
|
Gene: IMP4 (IMP U3 small nucleolar ribonucleoprotein 4)
Type: protein-coding
Summary: The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: maturation of SSU-rRNA, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: protein binding, rRNA binding, rRNA primary transcript binding, snoRNA binding; CC: Mpp10 complex, fibrillar center, nucleolus, nucleoplasm, nucleus, preribosome, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q96G21
Entrez ID: 92856
|
Does Knockout of TRAPPC11 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
TRAPPC11
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: TRAPPC11 (trafficking protein particle complex subunit 11)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: COPII vesicle coating, Golgi organization, constitutive secretory pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, regulation of protein complex stability, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TRAPP complex, TRAPPIII protein complex, cytoplasm, cytosol
Pathways: Genes related to primary cilium development (based on CRISPR), Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q7Z392
Entrez ID: 60684
|
Does Knockout of SORL1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
SORL1
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: SORL1 (sortilin related receptor 1)
Type: protein-coding
Summary: This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: adaptive thermogenesis, amyloid-beta formation, cell migration, diet induced thermogenesis, endocytosis, endosome to plasma membrane protein transport, insulin receptor recycling, negative regulation of BMP signaling pathway, negative regulation of amyloid precursor protein catabolic process, negative regulation of amyloid-beta formation, negative regulation of neurofibrillary tangle assembly, negative regulation of neurogenesis, negative regulation of protein-containing complex assembly, negative regulation of triglyceride catabolic process, neuropeptide signaling pathway, positive regulation of ER to Golgi vesicle-mediated transport, positive regulation of adipose tissue development, positive regulation of early endosome to recycling endosome transport, positive regulation of endocytic recycling, positive regulation of glial cell-derived neurotrophic factor production, positive regulation of insulin receptor signaling pathway, positive regulation of protein catabolic process, positive regulation of protein exit from endoplasmic reticulum, positive regulation of protein localization to early endosome, post-Golgi vesicle-mediated transport, protein localization to Golgi apparatus, protein retention in Golgi apparatus, protein targeting, protein targeting to lysosome, receptor-mediated endocytosis, regulation of smooth muscle cell migration, retrograde transport, endosome to Golgi; MF: amyloid-beta binding, aspartic-type endopeptidase inhibitor activity, low-density lipoprotein particle binding, low-density lipoprotein particle receptor activity, neuropeptide binding, protein binding, protein transporter activity, small GTPase binding, transmembrane signaling receptor activity; CC: Golgi apparatus, Golgi cisterna, Golgi membrane, cell surface, cytoplasmic vesicle, cytosol, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, extracellular exosome, extracellular region, extracellular space, membrane, multivesicular body, multivesicular body membrane, neuronal cell body, nuclear envelope lumen, perinucleolar compartment, plasma membrane, recycling endosome, recycling endosome membrane, trans-Golgi network, transport vesicle membrane
Pathways:
UniProt: Q92673
Entrez ID: 6653
|
Does Knockout of PTK2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
PTK2
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PTK2 (protein tyrosine kinase 2)
Type: protein-coding
Summary: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017].
Gene Ontology: BP: Fc-gamma receptor signaling pathway involved in phagocytosis, angiogenesis, axon guidance, cell differentiation, cell migration, cell motility, detection of muscle stretch, ephrin receptor signaling pathway, epidermal growth factor receptor signaling pathway, establishment of cell polarity, growth hormone receptor signaling pathway, heart morphogenesis, integrin-mediated signaling pathway, negative regulation of anoikis, negative regulation of apoptotic process, negative regulation of cell-cell adhesion, netrin-activated signaling pathway, peptidyl-tyrosine phosphorylation, placenta development, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of epithelial cell migration, positive regulation of epithelial to mesenchymal transition, positive regulation of fibroblast migration, positive regulation of macrophage chemotaxis, positive regulation of macrophage proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein kinase activity, positive regulation of protein phosphorylation, positive regulation of ubiquitin-dependent protein catabolic process, positive regulation of wound healing, protein autophosphorylation, regulation of GTPase activity, regulation of cell adhesion, regulation of cell adhesion mediated by integrin, regulation of cell differentiation, regulation of cell population proliferation, regulation of cell shape, regulation of cell-matrix adhesion, regulation of cytoskeleton organization, regulation of endothelial cell migration, regulation of epithelial cell migration, regulation of focal adhesion assembly, regulation of multicellular organismal process, regulation of osteoblast differentiation, regulation of protein phosphorylation, regulation of substrate adhesion-dependent cell spreading, signal complex assembly, transforming growth factor beta receptor signaling pathway, vascular endothelial cell response to oscillatory fluid shear stress, vascular endothelial growth factor receptor signaling pathway; MF: ATP binding, JUN kinase binding, SH2 domain binding, actin binding, integrin binding, kinase activity, molecular function activator activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein phosphatase binding, protein tyrosine kinase activity, protein tyrosine phosphatase activity, transferase activity; CC: anchoring junction, cell cortex, cell projection, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, focal adhesion, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, stress fiber
Pathways: Alpha 6 Beta 4 signaling pathway, Alpha4 beta1 integrin signaling events, Alpha6Beta4Integrin, Amoebiasis - Homo sapiens (human), Androgen receptor signaling pathway, AndrogenReceptor, Angiopoietin receptor Tie2-mediated signaling, Apoptosis, Apoptosis-related network due to altered Notch3 in ovarian cancer, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Axon guidance, Axon guidance - Homo sapiens (human), BCR, Bacterial invasion of epithelial cells - Homo sapiens (human), CRH, CXCR4-mediated signaling events, Caspase Cascade in Apoptosis, Cell-Cell communication, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Corticotropin-releasing hormone signaling pathway, DCC mediated attractive signaling, Developmental Biology, Disease, EGF-EGFR signaling pathway, EGFR1, EPH-Ephrin signaling, EPHA2 forward signaling, EPHB forward signaling, EPHB-mediated forward signaling, ESR-mediated signaling, ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Extra-nuclear estrogen signaling, FCGR3A-mediated phagocytosis, Fc-epsilon receptor I signaling in mast cells, Fcgamma receptor (FCGR) dependent phagocytosis, Fibroblast growth factor-1, Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), GRB2:SOS provides linkage to MAPK signaling for Integrins , Gastrin, Gastrin signaling pathway, Growth hormone synthesis, secretion and action - Homo sapiens (human), Hemostasis, Hippo-Merlin Signaling Dysregulation, Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IGF1 pathway, IL4, Immune System, Infectious disease, Innate Immune System, Integrin signaling, Integrin-mediated Cell Adhesion, Integrins in angiogenesis, Internalization of ErbB1, LPA receptor mediated events, Leishmania infection, Leishmania phagocytosis, Leptin, Leptin signaling pathway, Leukocyte transendothelial migration - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), MAPK family signaling cascades, MAPK1/MAPK3 signaling, MET activates PTK2 signaling, MET promotes cell motility, MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement, MFAP5-mediated ovarian cancer cell motility and invasiveness, NCAM signaling for neurite out-growth, Nectin adhesion pathway, Nervous system development, Netrin-1 signaling, Netrin-UNC5B signaling pathway, Netrin-mediated signaling events, Nongenotropic Androgen signaling, Overview of nanoparticle effects, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parasite infection, Parasitic Infection Pathways, Pathways in cancer - Homo sapiens (human), Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Primary focal segmental glomerulosclerosis (FSGS), Prion disease pathway, Programmed Cell Death, Prolactin, Prolactin Signaling Pathway, Proteoglycans in cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, RAF/MAP kinase cascade, RANKL, RANKL-RANK signaling pathway, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Response of endothelial cells to shear stress, Shigellosis - Homo sapiens (human), Signal Transduction, Signal regulatory protein family interactions, Signaling by MET, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by VEGFR1 and VEGFR2, Signaling events mediated by focal adhesion kinase, Signaling events regulated by Ret tyrosine kinase, Signaling of Hepatocyte Growth Factor Receptor, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Syndecan-4-mediated signaling events, TCR, TGF-beta Signaling Pathway, TGF_beta_Receptor, TNFalpha, Transcriptional misregulation in cancer - Homo sapiens (human), Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, VEGF signaling pathway - Homo sapiens (human), VEGFA-VEGFR2 Pathway, VEGFA-VEGFR2 Signaling Pathway, Yersinia infection - Homo sapiens (human), a4b7 Integrin signaling, agrin in postsynaptic differentiation, ccr3 signaling in eosinophils, cell to cell adhesion signaling, erk and pi-3 kinase are necessary for collagen binding in corneal epithelia, hiv-1 nef: negative effector of fas and tnf, integrin signaling pathway, mcalpain and friends in cell motility, p130Cas linkage to MAPK signaling for integrins, phospholipids as signalling intermediaries, pten dependent cell cycle arrest and apoptosis, role of nicotinic acetylcholine receptors in the regulation of apoptosis, ucalpain and friends in cell spread, vegf hypoxia and angiogenesis
UniProt: Q05397
Entrez ID: 5747
|
Does Knockout of CCDC174 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
CCDC174
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: CCDC174 (coiled-coil domain containing 174)
Type: protein-coding
Summary: The protein encoded by this gene is found in the nucleus, where it interacts with eukaryotic translation initiation factor 4A, isoform 3. The encoded protein appears to be a part of the exon junction complex, which is involved in RNA processing, translation, and nonsense-mediated mRNA decay. A mutation in this gene has been associated with infantile hypotonia with psychomotor retardation. [provided by RefSeq, Mar 2016].
Gene Ontology: CC: nucleoplasm, nucleus
Pathways:
UniProt: Q6PII3
Entrez ID: 51244
|
Does Knockout of CHST15 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
CHST15
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CHST15 (carbohydrate sulfotransferase 15)
Type: protein-coding
Summary: Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: chondroitin sulfate proteoglycan biosynthetic process, hexose biosynthetic process; MF: 3'-phosphoadenosine 5'-phosphosulfate binding, N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity, protein binding, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: BCR, CS-GAG biosynthesis, Chondroitin sulfate/dermatan sulfate metabolism, DS-GAG biosynthesis, Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human), Glycosaminoglycan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, chondroitin sulfate biosynthesis, chondroitin sulfate biosynthesis (late stages), dermatan sulfate biosynthesis, dermatan sulfate biosynthesis (late stages)
UniProt: Q7LFX5
Entrez ID: 51363
|
Does Knockout of ADGRV1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
ADGRV1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: ADGRV1 (adhesion G protein-coupled receptor V1)
Type: protein-coding
Summary: This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, animal organ development, cell communication, cell surface receptor signaling pathway, cell-cell adhesion, cellular response to calcium ion, detection of mechanical stimulus involved in sensory perception of sound, establishment of protein localization, inner ear development, inner ear receptor cell differentiation, inner ear receptor cell stereocilium organization, maintenance of animal organ identity, nervous system development, nervous system process, photoreceptor cell maintenance, positive regulation of bone mineralization, positive regulation of protein kinase A signaling, regulation of developmental process, regulation of protein stability, self proteolysis, sensory perception of light stimulus, sensory perception of sound, signal transduction, visual perception; MF: G protein-coupled receptor activity, G-protein alpha-subunit binding, adenylate cyclase inhibitor activity, calcium ion binding, hydrolase activity, protein binding, transmembrane signaling receptor activity; CC: USH2 complex, cell projection, cell surface, cytoplasm, extracellular exosome, membrane, periciliary membrane compartment, photoreceptor inner segment, plasma membrane, protein-containing complex, receptor complex, stereocilia ankle link, stereocilia ankle link complex, stereocilium, stereocilium membrane
Pathways: Developmental Biology, EGR2 and SOX10-mediated initiation of Schwann cell myelination, GPCRs, Other, Nervous system development
UniProt: Q8WXG9
Entrez ID: 84059
|
Does Knockout of ANKRD11 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
ANKRD11
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ANKRD11 (ankyrin repeat domain containing 11)
Type: protein-coding
Summary: This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: face development, face morphogenesis, head morphogenesis, odontogenesis of dentin-containing tooth, skeletal system morphogenesis; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q6UB99
Entrez ID: 29123
|
Does Knockout of AKT3 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
AKT3
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: AKT3 (AKT serine/threonine kinase 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: brain morphogenesis, homeostasis of number of cells within a tissue, insulin receptor signaling pathway, intracellular signal transduction, negative regulation of PERK-mediated unfolded protein response, negative regulation of apoptotic process, negative regulation of cellular senescence, positive regulation of TOR signaling, positive regulation of angiogenesis, positive regulation of artery morphogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of cell migration, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cell size, positive regulation of endothelial cell proliferation, positive regulation of vascular endothelial cell proliferation, protein phosphorylation, signal transduction; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, ciliary basal body, cilium, cytoplasm, cytosol, membrane, nucleoplasm, nucleus, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), AKT phosphorylates targets in the cytosol, AKT phosphorylates targets in the nucleus, AKT-mediated inactivation of FOXO1A, AMPK signaling pathway - Homo sapiens (human), Activation of BAD and translocation to mitochondria , Activation of BH3-only proteins, Acute myeloid leukemia - Homo sapiens (human), Adaptive Immune System, Adipocytokine signaling pathway - Homo sapiens (human), Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Apelin signaling pathway - Homo sapiens (human), Apoptosis, Apoptosis - Homo sapiens (human), Autophagy - animal - Homo sapiens (human), B cell receptor signaling pathway - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, C-type lectin receptor signaling pathway - Homo sapiens (human), CD28 dependent PI3K/Akt signaling, Carbohydrate digestion and absorption - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Cell migration and invasion through p75NTR, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Homo sapiens (human), Central carbon metabolism in cancer - Homo sapiens (human), Chagas disease - Homo sapiens (human), Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Choline metabolism in cancer - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Chromosomal and microsatellite instability in colorectal cancer, Chronic myeloid leukemia - Homo sapiens (human), Class I PI3K signaling events mediated by Akt, Co-inhibition by CTLA4, Co-stimulation by CD28, Colorectal cancer - Homo sapiens (human), Constitutive Signaling by AKT1 E17K in Cancer, Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA damage response (only ATM dependent), Developmental Biology, Diabetic cardiomyopathy - Homo sapiens (human), Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dopaminergic synapse - Homo sapiens (human), Downregulation of ERBB2 signaling, Downregulation of ERBB2:ERBB3 signaling, EGFR Tyrosine Kinase Inhibitor Resistance, ESC Pluripotency Pathways, ESR-mediated signaling, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Epithelial to mesenchymal transition in colorectal cancer, Epstein-Barr virus infection - Homo sapiens (human), ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), Estrogen signaling pathway - Homo sapiens (human), Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Extra-nuclear estrogen signaling, FLT3 Signaling, FOXO-mediated transcription, Fc epsilon RI signaling pathway - Homo sapiens (human), Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), FoxO signaling pathway - Homo sapiens (human), G beta:gamma signalling through PI3Kgamma, G-protein beta:gamma signalling, G1/S Transition, GPCR downstream signalling, Gastric cancer - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, Glioblastoma signaling pathways, Glioma - Homo sapiens (human), Glucagon signaling pathway - Homo sapiens (human), GnRH secretion - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), HIF-1 signaling pathway - Homo sapiens (human), Head and Neck Squamous Cell Carcinoma, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Infectious disease, Influenza A - Homo sapiens (human), Insulin resistance - Homo sapiens (human), Insulin signaling pathway - Homo sapiens (human), Integrin-mediated Cell Adhesion, Intracellular signaling by second messengers, Intrinsic Pathway for Apoptosis, JAK-STAT signaling pathway - Homo sapiens (human), KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Lipid Metabolism Pathway, Lipid and atherosclerosis - Homo sapiens (human), Longevity regulating pathway - Homo sapiens (human), Longevity regulating pathway - multiple species - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), MITF-M-regulated melanocyte development, Measles - Homo sapiens (human), Melanoma, Melanoma - Homo sapiens (human), Membrane Trafficking, Mitotic G1 phase and G1/S transition, Negative regulation of the PI3K/AKT network, Neural Crest Cell Migration during Development, Neural Crest Cell Migration in Cancer, Neurotrophin signaling pathway - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), Non-alcoholic fatty liver disease - Homo sapiens (human), Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Nonalcoholic fatty liver disease, Osteoclast differentiation - Homo sapiens (human), Overview of nanoparticle effects, PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, PTEN Regulation, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Platelet activation - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), Programmed Cell Death, Prolactin signaling pathway - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAB GEFs exchange GTP for GDP on RABs, RNA Polymerase II Transcription, RUNX2 regulates genes involved in cell migration, Rab regulation of trafficking, Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of PTEN stability and activity, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of TP53 Activity through Association with Co-factors, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of beta-cell development, Regulation of gene expression in beta cells, Regulation of lipolysis in adipocytes - Homo sapiens (human), Regulation of localization of FOXO transcription factors, Regulation of toll-like receptor signaling pathway, Relationship between inflammation, COX-2 and EGFR, Relaxin signaling pathway - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), Resistin as a regulator of inflammation, S Phase, S1P3 pathway, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 targets host intracellular signalling and regulatory pathways, SARS-CoV-2-host interactions, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signal Transduction, Signal Transduction of S1P Receptor, Signaling by ERBB2, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Sphingolipid signaling pathway - Homo sapiens (human), Spinocerebellar ataxia - Homo sapiens (human), Synaptic signaling pathways associated with autism spectrum disorder, T cell receptor signaling pathway - Homo sapiens (human), TNF signaling pathway - Homo sapiens (human), TP53 Regulates Metabolic Genes, Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, Toll-like Receptor Signaling Pathway, Toll-like receptor signaling pathway - Homo sapiens (human), Toxoplasmosis - Homo sapiens (human), Transcriptional Regulation by TP53, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional regulation by RUNX2, Translation inhibitors in chronically activated PDGFRA cells, Tuberculosis - Homo sapiens (human), VEGF signaling pathway - Homo sapiens (human), VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, Vesicle-mediated transport, Viral Infection Pathways, Yersinia infection - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human), mTOR signaling pathway - Homo sapiens (human)
UniProt: Q9Y243
Entrez ID: 10000
|
Does Knockout of GSS in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
GSS
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GSS (glutathione synthetase)
Type: protein-coding
Summary: Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: amino acid metabolic process, glutathione biosynthetic process, nervous system development, response to cadmium ion, response to oxidative stress; MF: ATP binding, glutathione binding, glutathione synthase activity, identical protein binding, ligase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity; CC: cytosol, extracellular exosome
Pathways: γ-glutamyl cycle, 2-Hydroxyglutric Aciduria (D And L Form), 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency, 5-Oxoprolinuria, 5-oxoprolinase deficiency, Amino Acid metabolism, Biological oxidations, Cysteine and methionine metabolism - Homo sapiens (human), Defective GSS causes GSS deficiency, Disease, Diseases of metabolism, Ferroptosis, Ferroptosis - Homo sapiens (human), Gamma-Glutamyltransferase Deficiency, Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases, Gamma-glutamyl-transpeptidase deficiency, Glutamate Metabolism, Glutathione Metabolism, Glutathione Synthetase Deficiency, Glutathione conjugation, Glutathione metabolism, Glutathione metabolism - Homo sapiens (human), Glutathione synthesis and recycling, Homocarnosinosis, Hyperinsulinism-Hyperammonemia Syndrome, Metabolic disorders of biological oxidation enzymes, Metabolism, Metapathway biotransformation Phase I and II, One-carbon metabolism and related pathways, Phase II - Conjugation of compounds, Succinic semialdehyde dehydrogenase deficiency, Trans-sulfuration and one-carbon metabolism, glutathione biosynthesis
UniProt: P48637
Entrez ID: 2937
|
Does Knockout of POLE in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
POLE
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: POLE (DNA polymerase epsilon, catalytic subunit)
Type: protein-coding
Summary: This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA replication proofreading, DNA synthesis involved in DNA repair, DNA-templated DNA replication, G1/S transition of mitotic cell cycle, base-excision repair, gap-filling, embryonic organ development, leading strand elongation, mitotic cell cycle, nucleotide-excision repair, DNA gap filling; MF: 4 iron, 4 sulfur cluster binding, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, chromatin binding, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, protein binding, single-stranded DNA 3'-5' DNA exonuclease activity, transferase activity, zinc ion binding; CC: epsilon DNA polymerase complex, nucleoplasm, nucleus, plasma membrane
Pathways: Activation of the pre-replicative complex, Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA replication initiation, Dual Incision in GG-NER, Dual incision in TC-NER, G1 to S cell cycle control, G1/S Transition, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Mitotic G1 phase and G1/S transition, Nucleotide Excision Repair, Nucleotide Excision Repair , Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Pyrimidine metabolism, Recognition of DNA damage by PCNA-containing replication complex, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q07864
Entrez ID: 5426
|
Does Knockout of NAA25 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
NAA25
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit)
Type: protein-coding
Summary: This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010].
Gene Ontology: MF: acetyltransferase activator activity, protein binding; CC: Golgi apparatus, NatB complex, cytoplasm, cytosol
Pathways:
UniProt: Q14CX7
Entrez ID: 80018
|
Does Knockout of ATP1B3 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
ATP1B3
|
cell proliferation
|
T-lymphoma cell line
|
Gene: ATP1B3 (ATPase Na+/K+ transporting subunit beta 3)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: intracellular potassium ion homeostasis, intracellular sodium ion homeostasis, membrane repolarization, monoatomic ion transport, positive regulation of potassium ion import across plasma membrane, positive regulation of sodium ion export across plasma membrane, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, protein localization to plasma membrane, protein stabilization, sodium ion export across plasma membrane, sodium ion transmembrane transport, sodium ion transport; MF: ATPase activator activity, ATPase binding, protein binding, protein-macromolecule adaptor activity, transporter activator activity; CC: apical plasma membrane, basolateral plasma membrane, cytoplasm, extracellular exosome, melanosome, membrane, plasma membrane, sodium:potassium-exchanging ATPase complex, sperm flagellum
Pathways: 3-Methylthiofentanyl Action Pathway, Acebutolol Action Pathway, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Aldosterone-regulated sodium reabsorption - Homo sapiens (human), Alfentanil Action Pathway, Alprenolol Action Pathway, Alvimopan Action Pathway, Amiloride Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Anileridine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Basigin interactions, Bendroflumethiazide Action Pathway, Benzocaine Action Pathway, Betaxolol Action Pathway, Bevantolol Action Pathway, Bile secretion - Homo sapiens (human), Bisoprolol Action Pathway, Blue diaper syndrome, Bopindolol Action Pathway, Bumetanide Action Pathway, Bupivacaine Action Pathway, Bupranolol Action Pathway, Buprenorphine Action Pathway, Calcium Regulation in the Cardiac Cell, Carbohydrate digestion and absorption - Homo sapiens (human), Cardiac conduction, Cardiac muscle contraction - Homo sapiens (human), Carfentanil Action Pathway, Carteolol Action Pathway, Carvedilol Action Pathway, Cell surface interactions at the vascular wall, Chloroprocaine Action Pathway, Chlorothiazide Action Pathway, Chlorthalidone Action Pathway, Citalopram Action Pathway, Cocaine Action Pathway, Codeine Action Pathway, Cyclothiazide Action Pathway, Cystinuria, Desipramine Action Pathway, Dezocine Action Pathway, Dibucaine Action Pathway, Dihydromorphine Action Pathway, Diltiazem Action Pathway, Dimethylthiambutene Action Pathway, Diphenoxylate Action Pathway, Disease, Disopyramide Action Pathway, Dobutamine Action Pathway, Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), Epinephrine Action Pathway, Eplerenone Action Pathway, Escitalopram Action Pathway, Esmolol Action Pathway, Ethacrynic Acid Action Pathway, Ethylmorphine Action Pathway, Felodipine Action Pathway, Fentanyl Action Pathway, Flecainide Action Pathway, Fluoxetine Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, Furosemide Action Pathway, Gastric acid secretion - Homo sapiens (human), Glucose Transporter Defect (SGLT2), Hartnup Disorder, Hemostasis, Heroin Action Pathway, Hydrochlorothiazide Action Pathway, Hydrocodone Action Pathway, Hydroflumethiazide Action Pathway, Hydromorphone Action Pathway, Ibutilide Action Pathway, Iminoglycinuria, Imipramine Action Pathway, Indapamide Action Pathway, Infectious disease, Insulin secretion - Homo sapiens (human), Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Isoprenaline Action Pathway, Isradipine Action Pathway, Ketobemidone Action Pathway, Kidney Function, Labetalol Action Pathway, Lactose Degradation, Lactose Intolerance, Levallorphan Action Pathway, Levobunolol Action Pathway, Levobupivacaine Action Pathway, Levomethadyl Acetate Action Action Pathway, Levorphanol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, Lidocaine (Local Anaesthetic) Action Pathway, Lysinuric Protein Intolerance, Lysinuric protein intolerance (LPI), Mepivacaine Action Pathway, Methadone Action Pathway, Methadyl Acetate Action Pathway, Methyclothiazide Action Pathway, Metipranolol Action Pathway, Metolazone Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Mineral absorption - Homo sapiens (human), Morphine Action Pathway, Muscle contraction, Muscle/Heart Contraction, Nadolol Action Pathway, Nalbuphine Action Pathway, Naloxone Action Pathway, Naltrexone Action Pathway, Nebivolol Action Pathway, Nicotine Action Pathway, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Oxybuprocaine Action Pathway, Oxycodone Action Pathway, Oxymorphone Action Pathway, Pancreatic secretion - Homo sapiens (human), Penbutolol Action Pathway, Pentazocine Action Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Polythiazide Action Pathway, Potential therapeutics for SARS, Practolol Action Pathway, Prilocaine Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Procaine Action Pathway, Proparacaine Action Pathway, Propoxyphene Action Pathway, Propranolol Action Pathway, Protein digestion and absorption - Homo sapiens (human), Proximal tubule bicarbonate reclamation - Homo sapiens (human), Quinethazone Action Pathway, Quinidine Action Pathway, Remifentanil Action Pathway, Ropivacaine Action Pathway, SARS-CoV Infections, Salivary secretion - Homo sapiens (human), Sotalol Action Pathway, Spironolactone Action Pathway, Sufentanil Action Pathway, Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid hormone synthesis - Homo sapiens (human), Timolol Action Pathway, Tocainide Action Pathway, Torsemide Action Pathway, Tramadol Action Action Pathway, Transport of small molecules, Trehalose Degradation, Triamterene Action Pathway, Trichlormethiazide Action Pathway, Verapamil Action Pathway, Viral Infection Pathways, cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P54709
Entrez ID: 483
|
Does Knockout of DIS3 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
DIS3
|
cell proliferation
|
Cancer Cell Line
|
Gene: DIS3 (DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease)
Type: protein-coding
Summary: Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CUT catabolic process, RNA catabolic process, RNA processing, nuclear mRNA surveillance of mRNA 3'-end processing, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, rRNA catabolic process, rRNA processing; MF: 3'-5'-RNA exonuclease activity, RNA binding, RNA nuclease activity, endonuclease activity, exonuclease activity, guanyl-nucleotide exchange factor activity, hydrolase activity, nuclease activity, protein binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, exosome (RNase complex), membrane, nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Cellular responses to stimuli, Cellular responses to stress, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, PERK regulates gene expression, RNA degradation - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, Unfolded Protein Response (UPR), mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y2L1
Entrez ID: 22894
|
Does Knockout of MMS19 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
MMS19
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: MMS19 (MMS19 cytosolic iron-sulfur assembly component)
Type: protein-coding
Summary: Enables estrogen receptor binding activity and transcription coactivator activity. Involved in several processes, including iron-sulfur cluster assembly; positive regulation of nucleobase-containing compound metabolic process; and protein maturation by iron-sulfur cluster transfer. Located in cytosol; nucleoplasm; and spindle. Part of CIA complex and MMXD complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, chromosome segregation, positive regulation of DNA-templated transcription, protein maturation; MF: enzyme binding, nuclear estrogen receptor binding, protein binding, protein-macromolecule adaptor activity, signaling receptor complex adaptor activity, transcription coactivator activity; CC: MMXD complex, centrosome, cytoplasm, cytoskeleton, cytosol, cytosolic [4Fe-4S] assembly targeting complex, membrane, nucleoplasm, nucleus, spindle, transcription factor TFIIH holo complex
Pathways: Cytosolic iron-sulfur cluster assembly, Metabolism
UniProt: Q96T76
Entrez ID: 64210
|
Does Knockout of LIMS3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
LIMS3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: LIMS3 (LIM zinc finger domain containing 3)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to be located in cytoplasm; focal adhesion; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: P0CW20, P0CW19
Entrez ID: 96626
|
Does Knockout of POTEG in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
POTEG
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: POTEG (POTE ankyrin domain family member G)
Type: protein-coding
Summary: POTE ankyrin domain family member G
Gene Ontology:
Pathways:
UniProt: Q6S5H5
Entrez ID: 404785
|
Does Knockout of KAT8 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
KAT8
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: KAT8 (lysine acetyltransferase 8)
Type: protein-coding
Summary: This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: chromatin organization, dosage compensation by inactivation of X chromosome, epigenetic regulation of gene expression, epithelial to mesenchymal transition, hemopoiesis, membraneless organelle assembly, myeloid cell differentiation, negative regulation of DNA-templated transcription, negative regulation of epithelial to mesenchymal transition, negative regulation of macromolecule biosynthetic process, negative regulation of multicellular organismal process, negative regulation of type I interferon production, neurogenesis, oogenesis, positive regulation of DNA-templated transcription, positive regulation of epithelial to mesenchymal transition, positive regulation of skeletal muscle satellite cell differentiation, positive regulation of transcription initiation by RNA polymerase II, positive regulation of type I interferon production, post-embryonic hemopoiesis, regulation of DNA-templated transcription, regulation of autophagy, regulation of cell differentiation, regulation of mRNA processing, regulation of mitochondrial transcription, skeletal muscle satellite cell differentiation, transcription initiation-coupled chromatin remodeling; MF: DNA-binding transcription factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, acetyltransferase activity, acyltransferase activity, enzyme binding, histone H4 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone acetyltransferase activity, metal ion binding, promoter-specific chromatin binding, protein binding, protein propionyltransferase activity, protein-lysine-acetyltransferase activity, transcription coactivator activity, transferase activity, zinc ion binding; CC: MLL1 complex, MSL complex, NSL complex, NuA4 histone acetyltransferase complex, chromosome, histone acetyltransferase complex, kinetochore, mitochondrion, nuclear lumen, nuclear matrix, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones, p53 pathway
UniProt: Q9H7Z6
Entrez ID: 84148
|
Does Knockout of ACTL7B in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
ACTL7B
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ACTL7B (actin like 7B)
Type: protein-coding
Summary: The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: protein binding, structural constituent of cytoskeleton; CC: actin cytoskeleton, cytoplasm, cytoskeleton, nucleus
Pathways:
UniProt: Q9Y614
Entrez ID: 10880
|
Does Knockout of RAN in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
RAN
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: RAN (RAN, member RAS oncogene family)
Type: protein-coding
Summary: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA metabolic process, GTP metabolic process, actin cytoskeleton organization, cell division, cellular response to mineralocorticoid stimulus, glycolytic process, hippocampus development, intracellular protein localization, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle organization, nucleocytoplasmic transport, positive regulation of protein import into nucleus, pre-miRNA export from nucleus, protein export from nucleus, protein import into nucleus, protein localization to nucleolus, protein transport, protein-containing complex localization, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus, ribosomal subunit export from nucleus, snRNA import into nucleus, spermatid development, viral process; MF: G protein activity, GDP binding, GTP binding, GTPase activity, RNA binding, cadherin binding, chromatin binding, dynein intermediate chain binding, hydrolase activity, importin-alpha family protein binding, magnesium ion binding, metal ion binding, nuclear export signal receptor activity, nucleotide binding, pre-miRNA binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein-containing complex binding; CC: Flemming body, RNA nuclear export complex, centriole, chromatin, cytoplasm, cytosol, extracellular exosome, male germ cell nucleus, manchette, melanosome, membrane, midbody, nuclear envelope, nuclear pore, nucleolus, nucleoplasm, nucleus, protein-containing complex, recycling endosome, sperm flagellum
Pathways: 22q11.2 copy number variation syndrome, Androgen receptor signaling pathway, AndrogenReceptor, Aurora A signaling, Canonical NF-kappaB pathway, Cell Cycle, Cell Cycle, Mitotic, Disease, Export of Viral Ribonucleoproteins from Nucleus, Fibroblast growth factor-1, FoxO family signaling, Gene Silencing by RNA, Gene expression (Transcription), HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Infectious disease, Influenza Infection, Interactions of Rev with host cellular proteins, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of lipids, Metabolism of steroids, MicroRNA (miRNA) biogenesis, Mitotic Anaphase, Mitotic Metaphase and Anaphase, NEP/NS2 Interacts with the Cellular Export Machinery, Nuclear Envelope (NE) Reassembly, Nuclear import of Rev protein, Postmitotic nuclear pore complex (NPC) reformation, RNA transport - Homo sapiens (human), Regulation of cholesterol biosynthesis by SREBP (SREBF), Rev-mediated nuclear export of HIV RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Role of Calcineurin-dependent NFAT signaling in lymphocytes, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TCR, Transcriptional regulation by small RNAs, Viral Infection Pathways, cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, miRNA Biogenesis, role of ran in mitotic spindle regulation, sumoylation by ranbp2 regulates transcriptional repression, tRNA processing, tRNA processing in the nucleus
UniProt: P62826
Entrez ID: 5901
|
Does Knockout of ESS2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
ESS2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ESS2 (ess-2 spliceosome associated protein)
Type: protein-coding
Summary: This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, nervous system development; CC: catalytic step 2 spliceosome, nucleus, spliceosomal complex
Pathways: 22q11.2 copy number variation syndrome
UniProt: Q96DF8
Entrez ID: 8220
|
Does Knockout of SAT2 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
SAT2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SAT2 (spermidine/spermine N1-acetyltransferase family member 2)
Type: protein-coding
Summary: Enables diamine N-acetyltransferase activity and identical protein binding activity. Involved in polyamine metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: nor-spermidine metabolic process, polyamine biosynthetic process, putrescine acetylation, spermidine acetylation, spermine acetylation; MF: N-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, diamine N-acetyltransferase activity, identical protein binding, protein binding, transferase activity; CC: cytoplasm, extracellular exosome
Pathways: Arginine and proline metabolism - Homo sapiens (human), Ferroptosis, Ferroptosis - Homo sapiens (human), putrescine degradation III, spermine and spermidine degradation I
UniProt: Q96F10
Entrez ID: 112483
|
Does Knockout of DKC1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
DKC1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DKC1 (dyskerin pseudouridine synthase 1)
Type: protein-coding
Summary: This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: RNA modification, RNA processing, box H/ACA sno(s)RNA 3'-end processing, box H/ACA sno(s)RNA metabolic process, enzyme-directed rRNA pseudouridine synthesis, mRNA pseudouridine synthesis, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein localization to Cajal body, pseudouridine synthesis, rRNA processing, rRNA pseudouridine synthesis, regulation of telomerase RNA localization to Cajal body, ribosome biogenesis, scaRNA localization to Cajal body, snRNA pseudouridine synthesis, telomerase RNA stabilization, telomerase holoenzyme complex assembly, telomere maintenance via telomerase; MF: RNA binding, box H/ACA snoRNA binding, isomerase activity, protein binding, pseudouridine synthase activity, telomerase RNA binding, telomerase activity; CC: Cajal body, box H/ACA scaRNP complex, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, cytoplasm, fibrillar center, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Metabolism of RNA, Regulation of Telomerase, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Telomere Extension By Telomerase, Telomere Maintenance, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O60832
Entrez ID: 1736
|
Does Knockout of TBCE in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
TBCE
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TBCE (tubulin folding cofactor E)
Type: protein-coding
Summary: Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adult locomotory behavior, axonogenesis, developmental growth, microtubule cytoskeleton organization, mitotic spindle organization, muscle atrophy, peripheral nervous system neuron axonogenesis, post-chaperonin tubulin folding pathway, post-embryonic development, protein folding, tubulin complex assembly; MF: alpha-tubulin binding, protein binding, protein-folding chaperone binding; CC: cytoplasm, cytoskeleton, microtubule
Pathways: Metabolism of proteins, Post-chaperonin tubulin folding pathway, Protein folding
UniProt: Q15813
Entrez ID: 6905
|
Does Knockout of A2ML1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
A2ML1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: A2ML1 (alpha-2-macroglobulin like 1)
Type: protein-coding
Summary: This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
Gene Ontology: MF: endopeptidase inhibitor activity, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular exosome, extracellular region, extracellular space
Pathways:
UniProt: A8K2U0
Entrez ID: 144568
|
Does Knockout of IBTK in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
IBTK
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: IBTK (inhibitor of Bruton tyrosine kinase)
Type: protein-coding
Summary: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: negative regulation of protein phosphorylation, release of sequestered calcium ion into cytosol; MF: protein kinase binding, protein tyrosine kinase inhibitor activity; CC: cytoplasm, membrane, nucleoplasm, nucleus
Pathways: BCR signaling pathway
UniProt: Q9P2D0
Entrez ID: 25998
|
Does Knockout of RFC2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
RFC2
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: RFC2 (replication factor C subunit 2)
Type: protein-coding
Summary: This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: DNA repair, DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA clamp loader activity, enzyme binding, nucleotide binding, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, chromosome, nucleoplasm, nucleus
Pathways: ATR signaling pathway, DNA Mismatch Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), Fanconi anemia pathway, Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human)
UniProt: P35250
Entrez ID: 5982
|
Does Knockout of SLC7A11 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
SLC7A11
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SLC7A11 (solute carrier family 7 member 11)
Type: protein-coding
Summary: This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: L-cystine transport, L-glutamate import across plasma membrane, L-glutamate transmembrane transport, L-kynurenine transmembrane transport, adult behavior, amino acid transmembrane transport, amino acid transport, brain development, cellular response to oxidative stress, cellular response to stress, dipeptide import across plasma membrane, glutathione metabolic process, glutathione transmembrane transport, intracellular glutamate homeostasis, limb development, lung alveolus development, modulation of chemical synaptic transmission, negative regulation of ferroptosis, platelet aggregation, regulation of AMPA glutamate receptor clustering, regulation of cell population proliferation, regulation of cellular response to oxidative stress, regulation of cysteine metabolic process, regulation of glutamate metabolic process, regulation of glutathione biosynthetic process, regulation of melanin biosynthetic process, regulation of neutrophil apoptotic process, regulation of programmed cell death, regulation of protein transport, regulation of synapse organization, response to redox state, response to toxic substance, striatum development, transmembrane transport, ventricular system development, visual learning; MF: L-amino acid transmembrane transporter activity, L-kynurenine transmembrane transporter activity, cystine:glutamate antiporter activity, protein binding, transmembrane transporter activity; CC: apical part of cell, astrocyte projection, brush border membrane, cell projection, cell surface, membrane, microvillus membrane, plasma membrane
Pathways: Amino acid transport across the plasma membrane, Basigin interactions, Cell surface interactions at the vascular wall, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Ferroptosis, Ferroptosis - Homo sapiens (human), Hemostasis, KEAP1-NFE2L2 pathway, NFE2L2 regulating anti-oxidant/detoxification enzymes, NRF2 pathway, NRF2-ARE regulation, Nuclear Receptors Meta-Pathway, Nuclear events mediated by NFE2L2, Phytochemical activity on NRF2 transcriptional activation, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transport of small molecules, p53 transcriptional gene network
UniProt: Q9UPY5
Entrez ID: 23657
|
Does Knockout of KRTAP5-9 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
KRTAP5-9
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: KRTAP5-9 (keratin associated protein 5-9)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in epidermis development. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: identical protein binding, protein binding; CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: P26371
Entrez ID: 3846
|
Does Knockout of RAD9A in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
RAD9A
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: RAD9A (RAD9 checkpoint clamp component A)
Type: protein-coding
Summary: This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, DNA replication checkpoint signaling, cellular response to ionizing radiation, intrinsic apoptotic signaling pathway in response to DNA damage, mitotic intra-S DNA damage checkpoint signaling, positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; MF: 3'-5' exonuclease activity, SH3 domain binding, double-stranded DNA 3'-5' DNA exonuclease activity, enzyme binding, exonuclease activity, histone deacetylase binding, hydrolase activity, nuclease activity, protein binding, protein kinase binding; CC: checkpoint clamp complex, cytoplasm, nucleoplasm, nucleus
Pathways: ATM Signaling Pathway, ATM pathway, ATR Signaling, ATR signaling pathway, Activation of ATR in response to replication stress, Androgen receptor signaling pathway, Cell Cycle, Cell Cycle Checkpoints, Cellular senescence - Homo sapiens (human), DNA Double-Strand Break Repair, DNA IR-double strand breaks and cellular response via ATM, DNA Repair, DNA damage response, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Fanconi anemia pathway, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Impaired BRCA2 binding to RAD51, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of Telomerase, Transcriptional Regulation by TP53, miRNA regulation of DNA damage response, role of brca1 brca2 and atr in cancer susceptibility
UniProt: Q99638
Entrez ID: 5883
|
Does Knockout of MED4 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
MED4
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: MED4 (mediator complex subunit 4)
Type: protein-coding
Summary: This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, protein binding, transcription coactivator activity, transcription coregulator activity; CC: core mediator complex, mediator complex, membrane, nucleoplasm, nucleus
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Thyroid hormone signaling pathway - Homo sapiens (human), Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9NPJ6
Entrez ID: 29079
|
Does Knockout of ISCU in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
ISCU
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ISCU (iron-sulfur cluster assembly enzyme)
Type: protein-coding
Summary: This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: [2Fe-2S] cluster assembly, [4Fe-4S] cluster assembly, intracellular iron ion homeostasis, iron-sulfur cluster assembly, negative regulation of iron ion import across plasma membrane, positive regulation of mitochondrial electron transport, NADH to ubiquinone; MF: 2 iron, 2 sulfur cluster binding, ferrous iron binding, iron ion binding, iron-sulfur cluster binding, iron-sulfur cluster chaperone activity, metal ion binding, molecular adaptor activity, protein binding, protein homodimerization activity, zinc ion binding; CC: cytoplasm, cytosol, iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrial matrix, mitochondrion, nucleus
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Complex III assembly, Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Respiratory electron transport
UniProt: Q9H1K1
Entrez ID: 23479
|
Does Knockout of SEL1L in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
SEL1L
|
response to virus
|
Lung Cancer Cell Line
|
Gene: SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase)
Type: protein-coding
Summary: The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: ERAD pathway, Notch signaling pathway, protein secretion, protein stabilization, protein transport, response to endoplasmic reticulum stress, retrograde protein transport, ER to cytosol, triglyceride metabolic process; CC: Derlin-1 retrotranslocation complex, Hrd1p ubiquitin ligase ERAD-L complex, Hrd1p ubiquitin ligase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, Co-inhibition by PD-1, Defective CFTR causes cystic fibrosis, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, ER Quality Control Compartment (ERQC), Genotoxicity pathway, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Immune System, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Post-translational protein modification, Pre-NOTCH Expression and Processing, Pre-NOTCH Processing in Golgi, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by Hedgehog, Signaling by NOTCH, Transport of small molecules
UniProt: Q9UBV2
Entrez ID: 6400
|
Does Knockout of MYZAP in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
MYZAP
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: MYZAP (myocardial zonula adherens protein)
Type: protein-coding
Summary: This gene encodes a protein that is abundantly expressed in cardiac tissue. The encoded protein localizes to intercalated discs in cardiomyocytes and functions as an activator of Rho-dependent serum-response factor signaling. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and the neighboring downstream gene POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) and is represented with GeneID: 145781. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: intracellular signal transduction; CC: I band, RNA polymerase II, core complex, Z disc, anchoring junction, cortical actin cytoskeleton, cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, membrane, plasma membrane
Pathways:
UniProt: P0CAP1
Entrez ID: 100820829
|
Does Knockout of RACGAP1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
RACGAP1
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: RACGAP1 (Rac GTPase activating protein 1)
Type: protein-coding
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: Rho protein signal transduction, actomyosin contractile ring assembly, cell differentiation, cell division, erythrocyte differentiation, mitotic cytokinesis, mitotic spindle midzone assembly, monoatomic ion transport, neuroblast proliferation, positive regulation of cytokinesis, regulation of attachment of spindle microtubules to kinetochore, regulation of embryonic development, regulation of small GTPase mediated signal transduction, signal transduction, spermatogenesis, sulfate transmembrane transport; MF: GTPase activator activity, alpha-tubulin binding, beta-tubulin binding, gamma-tubulin binding, lipid binding, metal ion binding, microtubule binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding, protein kinase binding, protein-macromolecule adaptor activity, zinc ion binding; CC: Flemming body, acrosomal vesicle, centralspindlin complex, cleavage furrow, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, cytosol, extracellular exosome, membrane, microtubule, midbody, mitochondrion, mitotic spindle, nucleoplasm, nucleus, plasma membrane, spindle, spindle midzone
Pathways: Adaptive Immune System, Aurora B signaling, CDC42 GTPase cycle, COPI-dependent Golgi-to-ER retrograde traffic, EGFR1, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, RAC1 GTPase cycle, RAC1 signaling pathway, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, Regulation of CDC42 activity, Regulation of RAC1 activity, Signal Transduction, Signal Transduction of S1P Receptor, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport, Wnt signaling pathway and pluripotency
UniProt: Q9H0H5
Entrez ID: 29127
|
Does Knockout of FAAH2 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
FAAH2
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: FAAH2 (fatty acid amide hydrolase 2)
Type: protein-coding
Summary: This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: arachidonate metabolic process, lipid catabolic process, lipid metabolic process; MF: fatty acid amide hydrolase activity, hydrolase activity; CC: lipid droplet, membrane
Pathways: Arachidonate metabolism, Fatty acid metabolism, Metabolism, Metabolism of lipids, anandamide degradation
UniProt: Q6GMR7
Entrez ID: 158584
|
Does Knockout of CDH18 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
CDH18
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CDH18 (cadherin 18)
Type: protein-coding
Summary: This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
Gene Ontology: BP: adherens junction organization, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, homophilic cell adhesion via plasma membrane adhesion molecules; MF: beta-catenin binding, cadherin binding, calcium ion binding, metal ion binding; CC: adherens junction, catenin complex, membrane, plasma membrane
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Hippo-Merlin Signaling Dysregulation, Pathways Regulating Hippo Signaling
UniProt: Q13634
Entrez ID: 1016
|
Does Knockout of RACGAP1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
RACGAP1
|
cell proliferation
|
Cancer Cell Line
|
Gene: RACGAP1 (Rac GTPase activating protein 1)
Type: protein-coding
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: Rho protein signal transduction, actomyosin contractile ring assembly, cell differentiation, cell division, erythrocyte differentiation, mitotic cytokinesis, mitotic spindle midzone assembly, monoatomic ion transport, neuroblast proliferation, positive regulation of cytokinesis, regulation of attachment of spindle microtubules to kinetochore, regulation of embryonic development, regulation of small GTPase mediated signal transduction, signal transduction, spermatogenesis, sulfate transmembrane transport; MF: GTPase activator activity, alpha-tubulin binding, beta-tubulin binding, gamma-tubulin binding, lipid binding, metal ion binding, microtubule binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding, protein kinase binding, protein-macromolecule adaptor activity, zinc ion binding; CC: Flemming body, acrosomal vesicle, centralspindlin complex, cleavage furrow, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, cytosol, extracellular exosome, membrane, microtubule, midbody, mitochondrion, mitotic spindle, nucleoplasm, nucleus, plasma membrane, spindle, spindle midzone
Pathways: Adaptive Immune System, Aurora B signaling, CDC42 GTPase cycle, COPI-dependent Golgi-to-ER retrograde traffic, EGFR1, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, RAC1 GTPase cycle, RAC1 signaling pathway, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, Regulation of CDC42 activity, Regulation of RAC1 activity, Signal Transduction, Signal Transduction of S1P Receptor, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport, Wnt signaling pathway and pluripotency
UniProt: Q9H0H5
Entrez ID: 29127
|
Does Knockout of PTX3 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
PTX3
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: PTX3 (pentraxin 3)
Type: protein-coding
Summary: This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016].
Gene Ontology: BP: extracellular matrix organization, host-mediated suppression of symbiont invasion, host-mediated suppression of viral proces, immune response, immune system process, inflammatory response, innate immune response, negative regulation by host of viral glycoprotein metabolic process, negative regulation of glycoprotein metabolic process, opsonization, ovarian cumulus expansion, positive regulation of nitric oxide biosynthetic process, positive regulation of phagocytosis, response to other organism, response to yeast; MF: (1->3)-beta-D-glucan binding, complement component C1q complex binding, identical protein binding, protein binding, virion binding; CC: extracellular matrix, extracellular region, extracellular space, specific granule lumen, tertiary granule lumen
Pathways: Complement system, IL-18 signaling pathway, Lung fibrosis
UniProt: P26022
Entrez ID: 5806
|
Does Knockout of FAM110D in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
FAM110D
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: FAM110D (family with sequence similarity 110 member D)
Type: protein-coding
Summary: family with sequence similarity 110 member D
Gene Ontology:
Pathways:
UniProt: Q8TAY7
Entrez ID: 79927
|
Does Knockout of STX16 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
STX16
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: STX16 (syntaxin 16)
Type: protein-coding
Summary: This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011].
Gene Ontology: BP: endocytic recycling, intracellular protein transport, protein transport, retrograde transport, endosome to Golgi, vesicle docking, vesicle fusion, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding, protein binding, syntaxin binding; CC: Golgi apparatus, Golgi cisterna, Golgi membrane, SNARE complex, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum, focal adhesion, intracellular membrane-bounded organelle, membrane, perinuclear region of cytoplasm, synaptic vesicle membrane, trans-Golgi network, trans-Golgi network membrane
Pathways: Ectoderm Differentiation, SNARE interactions in vesicular transport - Homo sapiens (human)
UniProt: O14662
Entrez ID: 8675
|
Does Knockout of ARID4B in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
ARID4B
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ARID4B (AT-rich interaction domain 4B)
Type: protein-coding
Summary: This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin organization, establishment of Sertoli cell barrier, genomic imprinting, negative regulation of cell migration, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, spermatogenesis, transcription by RNA polymerase II; MF: DNA binding, protein binding, transcription cis-regulatory region binding; CC: Sin3-type complex, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Pathways affected in adenoid cystic carcinoma
UniProt: Q4LE39
Entrez ID: 51742
|
Does Knockout of PTPA in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
PTPA
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: PTPA (protein phosphatase 2 phosphatase activator)
Type: protein-coding
Summary: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitotic spindle organization, positive regulation of apoptotic process; MF: ATP binding, isomerase activity, metal ion binding, nucleotide binding, peptidyl-prolyl cis-trans isomerase activity, phosphatase activator activity, phosphatase binding, phosphoprotein phosphatase activity, protein binding, protein homodimerization activity, protein phosphatase 2A binding, protein phosphatase regulator activity, protein tyrosine phosphatase activator activity, signaling receptor binding; CC: ATPase complex, calcium channel complex, cytoplasm, extracellular exosome, nucleoplasm, nucleus, protein phosphatase type 2A complex
Pathways: ATM Signaling Network in Development and Disease, Constitutive Androstane Receptor Pathway, Diabetic cardiomyopathy - Homo sapiens (human), Glycogen Synthesis and Degradation, Insulin resistance - Homo sapiens (human), Interleukin-11 Signaling Pathway, Netrin-UNC5B signaling pathway, Nuclear Receptors Meta-Pathway, Validated targets of C-MYC transcriptional repression, Wnt signaling pathway and pluripotency, p53 pathway
UniProt: Q15257
Entrez ID: 5524
|
Does Knockout of CCDC86 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
CCDC86
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CCDC86 (coiled-coil domain containing 86)
Type: protein-coding
Summary: Enables RNA binding activity. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromosome segregation, mitotic nuclear division; MF: RNA binding, protein binding; CC: chromosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9H6F5
Entrez ID: 79080
|
Does Knockout of SEC23A in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
SEC23A
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: SEC23A (SEC23 homolog A, COPII component)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: COPII-coated vesicle budding, COPII-coated vesicle cargo loading, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein localization to plasma membrane, protein transport, vesicle-mediated transport; MF: GTPase activator activity, metal ion binding, protein binding, zinc ion binding; CC: COPII vesicle coat, COPII-coated ER to Golgi transport vesicle, ER to Golgi transport vesicle membrane, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, membrane, perinuclear region of cytoplasm
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, Class I MHC mediated antigen processing & presentation, Disease, ER to Golgi Anterograde Transport, Immune System, Infectious disease, MHC class II antigen presentation, Membrane Trafficking, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of cholesterol biosynthesis by SREBP (SREBF), SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Sterol regulatory element-binding proteins (SREBP) signaling, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q15436
Entrez ID: 10484
|
Does Knockout of AHCY in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
AHCY
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: AHCY (adenosylhomocysteinase)
Type: protein-coding
Summary: S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: S-adenosylmethionine cycle, one-carbon metabolic process; MF: adenosylhomocysteinase activity, hydrolase activity, protein binding; CC: cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, melanosome, nucleus
Pathways: Betaine Metabolism, Biological oxidations, Cystathionine Beta-Synthase Deficiency, Cysteine and methionine metabolism - Homo sapiens (human), Defective AHCY causes HMAHCHD, Disease, Diseases of metabolism, Ethanol effects on histone modifications, Folate Metabolism, Glycine N-methyltransferase Deficiency, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, Metabolic disorders of biological oxidation enzymes, Metabolism, Metabolism of amino acids and derivatives, Metabolism of ingested SeMet, Sec, MeSec into H2Se, Methionine Adenosyltransferase Deficiency, Methionine De Novo and Salvage Pathway, Methionine Metabolism, Methylation, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), One-carbon metabolism, Phase II - Conjugation of compounds, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, Selenoamino Acid Metabolism, Selenoamino acid metabolism, Sulfur amino acid metabolism, TCR, Trans-sulfuration and one-carbon metabolism, Trans-sulfuration pathway, cysteine biosynthesis, methionine degradation, superpathway of methionine degradation
UniProt: P23526
Entrez ID: 191
|
Does Knockout of NDUFA8 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
NDUFA8
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: NADH dehydrogenase (ubiquinone) activity, protein binding, protein-containing complex binding; CC: membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human)
UniProt: P51970
Entrez ID: 4702
|
Does Knockout of FHIT in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
FHIT
|
response to virus
|
Lung Cancer Cell Line
|
Gene: FHIT (fragile histidine triad diadenosine triphosphatase)
Type: protein-coding
Summary: The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: apoptotic process, diadenosine triphosphate catabolic process, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, purine nucleotide metabolic process; MF: adenosine 5'-monophosphoramidase activity, adenylylsulfatase activity, adenylylsulfate-ammonia adenylyltransferase activity, bis(5'-adenosyl)-triphosphatase activity, catalytic activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding, transferase activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, fibrillar center, mitochondrion, nucleus, plasma membrane
Pathways: Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Purine metabolism - Homo sapiens (human), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human)
UniProt: P49789
Entrez ID: 2272
|
Does Knockout of IGFBP4 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
IGFBP4
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: IGFBP4 (insulin like growth factor binding protein 4)
Type: protein-coding
Summary: This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, negative regulation of canonical Wnt signaling pathway, positive regulation of MAPK cascade, positive regulation of insulin-like growth factor receptor signaling pathway, regulation of cell growth, regulation of glucose metabolic process, regulation of growth, regulation of insulin-like growth factor receptor signaling pathway, signal transduction, type B pancreatic cell proliferation; MF: growth factor binding, insulin-like growth factor I binding, insulin-like growth factor II binding, insulin-like growth factor binding, protein binding, signaling receptor binding; CC: endoplasmic reticulum lumen, extracellular region, extracellular space
Pathways: Metabolism of proteins, Myometrial relaxation and contraction pathways, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Wnt signaling network
UniProt: P22692
Entrez ID: 3487
|
Does Knockout of PPP4R2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
PPP4R2
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PPP4R2 (protein phosphatase 4 regulatory subunit 2)
Type: protein-coding
Summary: The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: RNA splicing, mRNA processing, protein modification process, regulation of double-strand break repair, regulation of double-strand break repair via homologous recombination; MF: protein binding, protein phosphatase regulator activity, protein-macromolecule adaptor activity; CC: centrosome, chromatin, cytoplasm, cytoskeleton, nucleoplasm, nucleus, protein phosphatase 4 complex
Pathways: 16p11.2 proximal deletion syndrome, DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends
UniProt: Q9NY27
Entrez ID: 151987
|
Does Knockout of RSL24D1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
RSL24D1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: RSL24D1 (ribosomal L24 domain containing 1)
Type: protein-coding
Summary: This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24. Although this gene has been referred to as RPL24, L30, and 60S ribosomal protein L30 isolog in the sequence databases, it is distinct from the human genes officially named RPL24 (which itself has been referred to as ribosomal protein L30) and RPL30. The protein encoded by this gene localizes to the nucleolus and is thought to play a role in the biogenesis of the 60S ribosomal subunit. The precise function of this gene is currently unknown. This gene utilizes alternative polyadenylation signals and has multiple pseudogenes. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome biogenesis; MF: protein binding, structural constituent of ribosome; CC: nucleolus, nucleoplasm, nucleus
Pathways: Coronavirus disease - COVID-19 - Homo sapiens (human), Ribosome - Homo sapiens (human)
UniProt: Q9UHA3
Entrez ID: 51187
|
Does Knockout of PRPF40A in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
PRPF40A
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: PRPF40A (pre-mRNA processing factor 40A)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in several processes, including cytoskeleton organization; regulation of cell shape; and regulation of cytokinesis. Located in nuclear matrix and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, cell division, cell migration, cytoskeleton organization, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, regulation of cell shape, regulation of cytokinesis; MF: RNA binding, protein binding; CC: U1 snRNP, U2-type prespliceosome, membrane, nuclear matrix, nuclear speck, nucleoplasm, nucleus
Pathways: Spliceosome - Homo sapiens (human), mRNA Processing
UniProt: O75400
Entrez ID: 55660
|
Does Knockout of GCFC2 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
GCFC2
|
response to virus
|
Hepatoma Cell Line
|
Gene: GCFC2 (GC-rich sequence DNA-binding factor 2)
Type: protein-coding
Summary: The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal complex assembly; MF: DNA binding, protein binding; CC: U2-type post-mRNA release spliceosomal complex, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P16383
Entrez ID: 6936
|
Does Knockout of ME1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
ME1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ME1 (malic enzyme 1)
Type: protein-coding
Summary: This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: NAD+ metabolic process, NADP+ metabolic process, carbohydrate metabolic process, malate metabolic process, nucleotide biosynthetic process, protein homotetramerization, pyruvate metabolic process, regulation of NADP metabolic process, response to carbohydrate, response to hormone; MF: ADP binding, NAD binding, NADP binding, electron transfer activity, identical protein binding, magnesium ion binding, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, manganese ion binding, metal ion binding, oxaloacetate decarboxylase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein binding; CC: cytoplasm, cytosol, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Glutaminolysis and Cancer, KEAP1-NFE2L2 pathway, Leigh Syndrome, Metabolism, Metabolism of lipids, NFE2L2 regulating TCA cycle genes, NRF2 pathway, Nuclear Receptors Meta-Pathway, Nuclear events mediated by NFE2L2, PPAR signaling pathway, PPAR signaling pathway - Homo sapiens (human), PPARA activates gene expression, Pathways in clear cell renal cell carcinoma, Primary hyperoxaluria II, PH2, Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency), Pyruvate Dehydrogenase Complex Deficiency, Pyruvate Metabolism, Pyruvate kinase deficiency, Pyruvate metabolism, Pyruvate metabolism - Homo sapiens (human), Regulation of lipid metabolism by PPARalpha, Regulation of pyruvate metabolism, TCA cycle in senescence, Transfer of Acetyl Groups into Mitochondria, mechanism of gene regulation by peroxisome proliferators via ppara
UniProt: P48163
Entrez ID: 4199
|
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