prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of DNAJC17 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | DNAJC17 | cell proliferation | Melanoma Cell Line | Gene: DNAJC17 (DnaJ heat shock protein family (Hsp40) member C17)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and toxin transport. Predicted to be located in cytoplasm and nucleus... |
Does Knockout of CCP110 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | CCP110 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: CCP110 (centriolar coiled-coil protein 110)
Type: protein-coding
Summary: Involved in centriole replication; negative regulation of cilium assembly; and regulation of cytokinesis. Located in centriole and centrosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Ap... |
Does Knockout of RPL23 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | RPL23 | cell proliferation | Glioblastoma Cell Line | Gene: RPL23 (ribosomal protein L23)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of ATRIP in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | ATRIP | cell proliferation | Neuroblastoma Cell Line | Gene: ATRIP (ATR interacting protein)
Type: protein-coding
Summary: This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protei... |
Does Knockout of ILF3 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | ILF3 | cell proliferation | Prostate Cancer Cell Line | Gene: ILF3 (interleukin enhancer binding factor 3)
Type: protein-coding
Summary: This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a ... |
Does Knockout of RPL21 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | RPL21 | response to virus | Hepatoma Cell Line | Gene: RPL21 (ribosomal protein L21)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of CDC42EP3 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | CDC42EP3 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: CDC42EP3 (CDC42 effector protein 3)
Type: protein-coding
Summary: This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. T... |
Does Knockout of STXBP2 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | STXBP2 | cell proliferation | Cancer Cell Line | Gene: STXBP2 (syntaxin binding protein 2)
Type: protein-coding
Summary: This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic gran... |
Does Knockout of HOXB6 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | HOXB6 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: HOXB6 (homeobox B6)
Type: protein-coding
Summary: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription... |
Does Knockout of GTF2H4 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | GTF2H4 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: GTF2H4 (general transcription factor IIH subunit 4)
Type: protein-coding
Summary: Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and trans... |
Does Knockout of PSMC1 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | PSMC1 | cell proliferation | Renal Cancer Cell Line | Gene: PSMC1 (proteasome 26S subunit, ATPase 1)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are co... |
Does Knockout of FFAR3 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | FFAR3 | cell proliferation | Renal Cancer Cell Line | Gene: FFAR3 (free fatty acid receptor 3)
Type: protein-coding
Summary: Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and cellular response to fatty acid. Located in plasma membrane. [provided by Alliance of Genome Resou... |
Does Knockout of SFPQ in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | SFPQ | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: SFPQ (splicing factor proline and glutamine rich)
Type: protein-coding
Summary: Enables DNA binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; positive regulation of oxi... |
Does Knockout of SOCS1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | SOCS1 | cell proliferation | Medulloblastoma Cell Line | Gene: SOCS1 (suppressor of cytokine signaling 1)
Type: protein-coding
Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expr... |
Does Knockout of BDH2 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | BDH2 | response to virus | Huh-7 Cell | Gene: BDH2 (3-hydroxybutyrate dehydrogenase 2)
Type: protein-coding
Summary: Enables 3-hydroxybutyrate dehydrogenase activity and NAD binding activity. Involved in epithelial cell differentiation and fatty acid beta-oxidation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of RRP7A in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | RRP7A | cell proliferation | Colorectal Cancer Cell Line | Gene: RRP7A (ribosomal RNA processing 7 homolog A)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to act upstream of or within blastocyst formation. Predicted to be located in nucleoplasm. Predicted ... |
Does Knockout of CARS2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | CARS2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is enc... |
Does Knockout of RPS9 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | RPS9 | cell proliferation | Bladder Carcinoma | Gene: RPS9 (ribosomal protein S9)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ... |
Does Knockout of SORL1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | SORL1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: SORL1 (sortilin related receptor 1)
Type: protein-coding
Summary: This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also co... |
Does Knockout of INTS8 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | INTS8 | cell proliferation | Medulloblastoma Cell Line | Gene: INTS8 (integrator complex subunit 8)
Type: protein-coding
Summary: This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 sma... |
Does Knockout of UNG in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | UNG | cell proliferation | Cancer Cell Line | Gene: UNG (uracil DNA glycosylase)
Type: protein-coding
Summary: This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excisi... |
Does Knockout of PGAM1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | PGAM1 | cell proliferation | Colonic Cancer Cell Line | Gene: PGAM1 (phosphoglycerate mutase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been f... |
Does Knockout of CMC1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | CMC1 | cell proliferation | Endometrial Cancer Cell Line | Gene: CMC1 (C-X9-C motif containing 1)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and r... |
Does Knockout of MAT2A in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | MAT2A | cell proliferation | acute lymphoblastic leukemia cell line | Gene: MAT2A (methionine adenosyltransferase 2A)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011].
Gene Ontology: ... |
Does Knockout of ALG14 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | ALG14 | cell proliferation | Medulloblastoma Cell Line | Gene: ALG14 (ALG14 UDP-N-acetylglucosaminyltransferase subunit)
Type: protein-coding
Summary: This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticu... |
Does Knockout of PLAC8 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | PLAC8 | cell proliferation | Medulloblastoma Cell Line | Gene: PLAC8 (placenta associated 8)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several pr... |
Does Knockout of CPSF3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | CPSF3 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: CPSF3 (cleavage and polyadenylation specific factor 3)
Type: protein-coding
Summary: This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the p... |
Does Knockout of SLC10A2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | SLC10A2 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: SLC10A2 (solute carrier family 10 member 2)
Type: protein-coding
Summary: This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metab... |
Does Knockout of TRIP6 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | TRIP6 | cell proliferation | Renal Cancer Cell Line | Gene: TRIP6 (thyroid hormone receptor interactor 6)
Type: protein-coding
Summary: This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma m... |
Does Activation of LCE3E in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | LCE3E | response to virus | Hepatoma Cell Line | Gene: LCE3E (late cornified envelope 3E)
Type: protein-coding
Summary: Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epidermis development, keratinization
Pathways: Developmental Biology, Formation of the cornified e... |
Does Knockout of SMPDL3B in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | SMPDL3B | cell proliferation | Mammary Gland Tumor Cell Line | Gene: SMPDL3B (sphingomyelin phosphodiesterase acid like 3B)
Type: protein-coding
Summary: Enables phosphoric diester hydrolase activity. Predicted to be involved in membrane lipid catabolic process; negative regulation of inflammatory response; and negative regulation of toll-like receptor signaling pa... |
Does Knockout of RPS21 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | RPS21 | cell proliferation | Ovarian Cancer Cell Line | Gene: RPS21 (ribosomal protein S21)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of ALKBH4 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | ALKBH4 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: ALKBH4 (alkB homolog 4, lysine demethylase)
Type: protein-coding
Summary: Enables 2-oxoglutarate-dependent dioxygenase activity and actin binding activity. Involved in actomyosin structure organization; cleavage furrow ingression; and protein demethylation. Located in contractile ring and midbody.... |
Does Knockout of EIF3B in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | EIF3B | cell proliferation | Neuroblastoma Cell Line | Gene: EIF3B (eukaryotic translation initiation factor 3 subunit B)
Type: protein-coding
Summary: Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and vira... |
Does Knockout of NELFB in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | NELFB | cell proliferation | Breast Cancer Cell Line | Gene: NELFB (negative elongation factor complex member B)
Type: protein-coding
Summary: NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing ... |
Does Knockout of ILK in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | ILK | cell proliferation | Cancer Cell Line | Gene: ILK (integrin linked kinase)
Type: protein-coding
Summary: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transductio... |
Does Knockout of MYBPHL in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | MYBPHL | response to virus | Hepatoma Cell Line | Gene: MYBPHL (myosin binding protein H like)
Type: protein-coding
Summary: This gene encodes a protein with two immunoglobulin superfamily domains and a fibronectin 3 domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012].
Gene Ontology: BP: biologi... |
Does Knockout of RPL8 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | RPL8 | cell proliferation | Cancer Cell Line | Gene: RPL8 (ribosomal protein L8)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ... |
Does Knockout of WDR77 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | WDR77 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: WDR77 (WD repeat domain 77)
Type: protein-coding
Summary: The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded pro... |
Does Knockout of GTF2H1 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | GTF2H1 | cell proliferation | Cancer Cell Line | Gene: GTF2H1 (general transcription factor IIH subunit 1)
Type: protein-coding
Summary: Enables thyroid hormone receptor binding activity. Involved in positive regulation of transcription, DNA-templated and transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription factor TFIIH co... |
Does Knockout of RAB1A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | RAB1A | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: RAB1A (RAB1A, member RAS oncogene family)
Type: protein-coding
Summary: This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to... |
Does Knockout of C12orf76 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | C12orf76 | cell proliferation | Glioblastoma Cell Line | Gene: C12orf76 (chromosome 12 open reading frame 76)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: A0A494C145, A0A087WX00
Entrez ID: 400073 |
Does Knockout of MRPS6 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | MRPS6 | cell proliferation | Monocytic Leukemia Cell Line | Gene: MRPS6 (mitochondrial ribosomal protein S6)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. T... |
Does Knockout of CEP128 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | CEP128 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: CEP128 (centrosomal protein 128)
Type: protein-coding
Summary: Involved in protein localization. Located in centriole and spindle pole. Part of centriolar subdistal appendage. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intracellular protein localization, regul... |
Does Knockout of NPY in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | NPY | cell proliferation | Ewing's Sarcoma Cell Line | Gene: NPY (neuropeptide Y)
Type: protein-coding
Summary: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The... |
Does Knockout of DIAPH3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | DIAPH3 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: DIAPH3 (diaphanous related formin 3)
Type: protein-coding
Summary: This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal domi... |
Does Knockout of IMP4 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | IMP4 | cell proliferation | Bladder Carcinoma | Gene: IMP4 (IMP U3 small nucleolar ribonucleoprotein 4)
Type: protein-coding
Summary: The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal R... |
Does Knockout of TRAPPC11 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | TRAPPC11 | cell proliferation | Medulloblastoma Cell Line | Gene: TRAPPC11 (trafficking protein particle complex subunit 11)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplas... |
Does Knockout of SORL1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | SORL1 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: SORL1 (sortilin related receptor 1)
Type: protein-coding
Summary: This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also co... |
Does Knockout of PTK2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | PTK2 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: PTK2 (protein tyrosine kinase 2)
Type: protein-coding
Summary: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK... |
Does Knockout of CCDC174 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | CCDC174 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: CCDC174 (coiled-coil domain containing 174)
Type: protein-coding
Summary: The protein encoded by this gene is found in the nucleus, where it interacts with eukaryotic translation initiation factor 4A, isoform 3. The encoded protein appears to be a part of the exon junction complex, which is involv... |
Does Knockout of CHST15 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | CHST15 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CHST15 (carbohydrate sulfotransferase 15)
Type: protein-coding
Summary: Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin... |
Does Knockout of ADGRV1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | ADGRV1 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: ADGRV1 (adhesion G protein-coupled receptor V1)
Type: protein-coding
Summary: This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this ge... |
Does Knockout of ANKRD11 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | ANKRD11 | cell proliferation | Gastric Cancer Cell Line | Gene: ANKRD11 (ankyrin repeat domain containing 11)
Type: protein-coding
Summary: This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characteriz... |
Does Knockout of AKT3 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | AKT3 | response to chemicals | Monocytic Leukemia Cell Line | Gene: AKT3 (AKT serine/threonine kinase 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involve... |
Does Knockout of GSS in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | GSS | cell proliferation | Monocytic Leukemia Cell Line | Gene: GSS (glutathione synthetase)
Type: protein-coding
Summary: Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a ho... |
Does Knockout of POLE in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | POLE | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: POLE (DNA polymerase epsilon, catalytic subunit)
Type: protein-coding
Summary: This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial d... |
Does Knockout of NAA25 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | NAA25 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit)
Type: protein-coding
Summary: This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by ... |
Does Knockout of ATP1B3 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | ATP1B3 | cell proliferation | T-lymphoma cell line | Gene: ATP1B3 (ATPase Na+/K+ transporting subunit beta 3)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establish... |
Does Knockout of DIS3 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | DIS3 | cell proliferation | Cancer Cell Line | Gene: DIS3 (DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease)
Type: protein-coding
Summary: Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleop... |
Does Knockout of MMS19 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | MMS19 | cell proliferation | Ovarian Cancer Cell Line | Gene: MMS19 (MMS19 cytosolic iron-sulfur assembly component)
Type: protein-coding
Summary: Enables estrogen receptor binding activity and transcription coactivator activity. Involved in several processes, including iron-sulfur cluster assembly; positive regulation of nucleobase-containing compound metab... |
Does Knockout of LIMS3 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | LIMS3 | cell proliferation | Colonic Cancer Cell Line | Gene: LIMS3 (LIM zinc finger domain containing 3)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to be located in cytoplasm; focal adhesion; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
... |
Does Knockout of POTEG in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | POTEG | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: POTEG (POTE ankyrin domain family member G)
Type: protein-coding
Summary: POTE ankyrin domain family member G
Gene Ontology:
Pathways:
UniProt: Q6S5H5
Entrez ID: 404785 |
Does Knockout of KAT8 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | KAT8 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: KAT8 (lysine acetyltransferase 8)
Type: protein-coding
Summary: This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-ty... |
Does Knockout of ACTL7B in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | ACTL7B | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: ACTL7B (actin like 7B)
Type: protein-coding
Summary: The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a c... |
Does Knockout of RAN in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | RAN | cell proliferation | Breast Cancer Cell Line | Gene: RAN (RAN, member RAS oncogene family)
Type: protein-coding
Summary: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in co... |
Does Knockout of ESS2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | ESS2 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ESS2 (ess-2 spliceosome associated protein)
Type: protein-coding
Summary: This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, con... |
Does Knockout of SAT2 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | SAT2 | cell proliferation | Glioblastoma Cell Line | Gene: SAT2 (spermidine/spermine N1-acetyltransferase family member 2)
Type: protein-coding
Summary: Enables diamine N-acetyltransferase activity and identical protein binding activity. Involved in polyamine metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, A... |
Does Knockout of DKC1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | DKC1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: DKC1 (dyskerin pseudouridine synthase 1)
Type: protein-coding
Summary: This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and ass... |
Does Knockout of TBCE in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | TBCE | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: TBCE (tubulin folding cofactor E)
Type: protein-coding
Summary: Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta... |
Does Knockout of A2ML1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | A2ML1 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: A2ML1 (alpha-2-macroglobulin like 1)
Type: protein-coding
Summary: This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interact... |
Does Knockout of IBTK in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | IBTK | cell proliferation | Colonic Cancer Cell Line | Gene: IBTK (inhibitor of Bruton tyrosine kinase)
Type: protein-coding
Summary: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the enc... |
Does Knockout of RFC2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | RFC2 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: RFC2 (replication factor C subunit 2)
Type: protein-coding
Summary: This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCN... |
Does Knockout of SLC7A11 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | SLC7A11 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SLC7A11 (solute carrier family 7 member 11)
Type: protein-coding
Summary: This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is trans... |
Does Knockout of KRTAP5-9 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | KRTAP5-9 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: KRTAP5-9 (keratin associated protein 5-9)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in epidermis development. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: identical prot... |
Does Knockout of RAD9A in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | RAD9A | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: RAD9A (RAD9 checkpoint clamp component A)
Type: protein-coding
Summary: This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contr... |
Does Knockout of MED4 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | MED4 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: MED4 (mediator complex subunit 4)
Type: protein-coding
Summary: This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encod... |
Does Knockout of ISCU in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | ISCU | cell proliferation | Endometrial Cancer Cell Line | Gene: ISCU (iron-sulfur cluster assembly enzyme)
Type: protein-coding
Summary: This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, a... |
Does Knockout of SEL1L in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | SEL1L | response to virus | Lung Cancer Cell Line | Gene: SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase)
Type: protein-coding
Summary: The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded ... |
Does Knockout of MYZAP in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | MYZAP | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: MYZAP (myocardial zonula adherens protein)
Type: protein-coding
Summary: This gene encodes a protein that is abundantly expressed in cardiac tissue. The encoded protein localizes to intercalated discs in cardiomyocytes and functions as an activator of Rho-dependent serum-response factor signaling.... |
Does Knockout of RACGAP1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | RACGAP1 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: RACGAP1 (Rac GTPase activating protein 1)
Type: protein-coding
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of R... |
Does Knockout of FAAH2 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | FAAH2 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: FAAH2 (fatty acid amide hydrolase 2)
Type: protein-coding
Summary: This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, includin... |
Does Knockout of CDH18 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | CDH18 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: CDH18 (cadherin 18)
Type: protein-coding
Summary: This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single... |
Does Knockout of RACGAP1 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | RACGAP1 | cell proliferation | Cancer Cell Line | Gene: RACGAP1 (Rac GTPase activating protein 1)
Type: protein-coding
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of R... |
Does Knockout of PTX3 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | PTX3 | cell proliferation | Colorectal Cancer Cell Line | Gene: PTX3 (pentraxin 3)
Type: protein-coding
Summary: This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and ... |
Does Knockout of FAM110D in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | FAM110D | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: FAM110D (family with sequence similarity 110 member D)
Type: protein-coding
Summary: family with sequence similarity 110 member D
Gene Ontology:
Pathways:
UniProt: Q8TAY7
Entrez ID: 79927 |
Does Knockout of STX16 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | STX16 | cell proliferation | Medulloblastoma Cell Line | Gene: STX16 (syntaxin 16)
Type: protein-coding
Summary: This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle do... |
Does Knockout of ARID4B in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | ARID4B | cell proliferation | Colonic Cancer Cell Line | Gene: ARID4B (AT-rich interaction domain 4B)
Type: protein-coding
Summary: This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse... |
Does Knockout of PTPA in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | PTPA | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: PTPA (protein phosphatase 2 phosphatase activator)
Type: protein-coding
Summary: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a ... |
Does Knockout of CCDC86 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | CCDC86 | cell proliferation | Endometrial Cancer Cell Line | Gene: CCDC86 (coiled-coil domain containing 86)
Type: protein-coding
Summary: Enables RNA binding activity. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromosome segregation, mitotic nuclear division; MF: RNA bindin... |
Does Knockout of SEC23A in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | SEC23A | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: SEC23A (SEC23 homolog A, COPII component)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated v... |
Does Knockout of AHCY in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | AHCY | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: AHCY (adenosylhomocysteinase)
Type: protein-coding
Summary: S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-a... |
Does Knockout of NDUFA8 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | NDUFA8 | response to chemicals | Monocytic Leukemia Cell Line | Gene: NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It p... |
Does Knockout of FHIT in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | FHIT | response to virus | Lung Cancer Cell Line | Gene: FHIT (fragile histidine triad diadenosine triphosphatase)
Type: protein-coding
Summary: The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced d... |
Does Knockout of IGFBP4 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | IGFBP4 | cell proliferation | Multiple Myeloma Cell Line | Gene: IGFBP4 (insulin like growth factor binding protein 4)
Type: protein-coding
Summary: This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factor... |
Does Knockout of PPP4R2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | PPP4R2 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PPP4R2 (protein phosphatase 4 regulatory subunit 2)
Type: protein-coding
Summary: The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in... |
Does Knockout of RSL24D1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | RSL24D1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: RSL24D1 (ribosomal L24 domain containing 1)
Type: protein-coding
Summary: This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24. Although this gene has been referred to as RPL24, L30, and 60S ribosomal protein L30 isolog in the sequence databases, ... |
Does Knockout of PRPF40A in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | PRPF40A | cell proliferation | Ovarian Cancer Cell Line | Gene: PRPF40A (pre-mRNA processing factor 40A)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in several processes, including cytoskeleton organization; regulation of cell shape; and regulation of cytokinesis. Located in nuclear matrix and nuclear speck. [provided by Alliance of Ge... |
Does Knockout of GCFC2 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | GCFC2 | response to virus | Hepatoma Cell Line | Gene: GCFC2 (GC-rich sequence DNA-binding factor 2)
Type: protein-coding
Summary: The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged am... |
Does Knockout of ME1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | ME1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: ME1 (malic enzyme 1)
Type: protein-coding
Summary: This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.