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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of DEFB106B in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
DEFB106B
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: DEFB106B (defensin beta 106B)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106B, represents the more telomeric copy. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: antifungal innate immune response, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, innate immune response; MF: CCR2 chemokine receptor binding, heparin binding, lipopolysaccharide binding, protein binding; CC: extracellular region, membrane, microvesicle, nucleus
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q8N104
Entrez ID: 503841
|
Does Knockout of PSEN1 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
PSEN1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: PSEN1 (presenilin 1)
Type: protein-coding
Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: Cajal-Retzius cell differentiation, DNA damage response, L-glutamate import across plasma membrane, Notch receptor processing, Notch signaling pathway, T cell activation involved in immune response, T cell receptor signaling pathway, amyloid precursor protein catabolic process, amyloid precursor protein metabolic process, amyloid-beta formation, amyloid-beta metabolic process, apoptotic process, apoptotic signaling pathway, astrocyte activation, astrocyte activation involved in immune response, autophagosome assembly, autophagy, blood vessel development, brain development, brain morphogenesis, calcium ion homeostasis, calcium ion transmembrane transport, cell adhesion, cell fate specification, cell-cell adhesion, cellular response to amyloid-beta, cerebellum development, cerebral cortex cell migration, cerebral cortex development, choline transport, dorsal/ventral neural tube patterning, embryonic limb morphogenesis, endoplasmic reticulum calcium ion homeostasis, epithelial cell proliferation, forebrain development, gene expression, heart development, heart looping, hematopoietic progenitor cell differentiation, intracellular calcium ion homeostasis, intracellular signal transduction, learning or memory, locomotion, membrane protein ectodomain proteolysis, memory, mitochondrial transport, myeloid dendritic cell differentiation, myeloid leukocyte differentiation, negative regulation of apoptotic process, negative regulation of apoptotic signaling pathway, negative regulation of axonogenesis, negative regulation of core promoter binding, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of gene expression, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, neural retina development, neurogenesis, neuron apoptotic process, neuron cellular homeostasis, neuron development, neuron differentiation, neuron migration, neuron projection maintenance, positive regulation of DNA-templated transcription, positive regulation of L-glutamate import across plasma membrane, positive regulation of amyloid fibril formation, positive regulation of apoptotic process, positive regulation of coagulation, positive regulation of dendritic spine development, positive regulation of gene expression, positive regulation of glycolytic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein import into nucleus, positive regulation of receptor recycling, positive regulation of tumor necrosis factor production, post-embryonic development, protein catabolic process at postsynapse, protein glycosylation, protein maturation, protein processing, protein transport, proteolysis, regulation of canonical Wnt signaling pathway, regulation of gene expression, regulation of neuron projection development, regulation of phosphorylation, regulation of postsynapse organization, regulation of resting membrane potential, regulation of synaptic plasticity, regulation of synaptic transmission, glutamatergic, regulation of synaptic vesicle cycle, response to oxidative stress, segmentation, sequestering of calcium ion, skeletal system morphogenesis, skin morphogenesis, smooth endoplasmic reticulum calcium ion homeostasis, somitogenesis, synapse organization, synaptic vesicle targeting, thymus development; MF: ATPase binding, PDZ domain binding, aspartic endopeptidase activity, intramembrane cleaving, aspartic-type endopeptidase activity, beta-catenin binding, cadherin binding, calcium channel activity, endopeptidase activity, growth factor receptor binding, hydrolase activity, peptidase activity, protein binding; CC: Golgi apparatus, Golgi membrane, aggresome, axon, azurophil granule membrane, cell cortex, cell junction, cell projection, cell surface, centrosome, ciliary rootlet, cytoplasm, cytoplasmic vesicle, dendrite, dendritic shaft, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, gamma-secretase complex, glutamatergic synapse, growth cone, kinetochore, lysosomal membrane, membrane, membrane raft, mitochondrial inner membrane, mitochondrion, neuromuscular junction, neuron projection, neuronal cell body, nuclear membrane, nuclear outer membrane, nucleoplasm, nucleus, plasma membrane, postsynapse, presynaptic membrane, protein-containing complex, rough endoplasmic reticulum, sarcolemma, smooth endoplasmic reticulum, synapse, synaptic membrane, synaptic vesicle
Pathways: Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Canonical and non-canonical Notch signaling, FGF signaling pathway, Human papillomavirus infection - Homo sapiens (human), Neurotrophin signaling pathway - Homo sapiens (human), Notch, Notch Signaling, Notch Signaling Pathway Netpath, Notch signaling pathway, Notch signaling pathway - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Presenilin action in Notch and Wnt signaling, Syndecan-3-mediated signaling events, Wnt signaling pathway - Homo sapiens (human), g-secretase mediated erbb4 signaling pathway, generation of amyloid b-peptide by ps1, hiv-1 nef: negative effector of fas and tnf, p75(NTR)-mediated signaling, proteolysis and signaling pathway of notch, segmentation clock
UniProt: P49768
Entrez ID: 5663
|
Does Knockout of MEF2D in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
MEF2D
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MEF2D (myocyte enhancer factor 2D)
Type: protein-coding
Summary: This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: adult heart development, animal organ development, apoptotic process, cell differentiation, muscle organ development, nervous system development, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell proliferation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, histone deacetylase binding, protein binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Adipogenesis, Apelin signaling pathway - Homo sapiens (human), B Cell Receptor Signaling Pathway, Cell Differentiation - Index, Cell Differentiation - Index expanded, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Developmental Biology, EGF-EGFR signaling pathway, Energy Metabolism, Epithelial to mesenchymal transition in colorectal cancer, Expression of BMAL (ARNTL), CLOCK, and NPAS2, Gastrin signaling pathway, Heme signaling, Mitochondrial biogenesis, Modulators of TCR signaling and T cell activation, Myogenesis, NGF-stimulated transcription, Nuclear Events (kinase and transcription factor activation), Organelle biogenesis and maintenance, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Role of Calcineurin-dependent NFAT signaling in lymphocytes, SRF and miRs in Smooth Muscle Differentiation and Proliferation, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling events mediated by HDAC Class III, Transcriptional activation of mitochondrial biogenesis, angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling, cGMP-PKG signaling pathway - Homo sapiens (human), control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk), mapkinase signaling pathway, p38 MAPK Signaling Pathway, p38 mapk signaling pathway, regulation of pgc-1a, role of erk5 in neuronal survival pathway, role of mef2d in t-cell apoptosis, signal dependent regulation of myogenesis by corepressor mitr
UniProt: Q14814
Entrez ID: 4209
|
Does Knockout of MIR3143 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
MIR3143
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: MIR3143 (microRNA 3143)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100422934
|
Does Knockout of BICDL2 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
BICDL2
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: BICDL2 (BICD family like cargo adaptor 2)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and vesicle transport along microtubule. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Golgi to secretory granule transport, vesicle transport along microtubule; MF: protein binding, small GTPase binding
Pathways:
UniProt: A1A5D9
Entrez ID: 146439
|
Does Knockout of FAM181B in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
FAM181B
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: FAM181B (family with sequence similarity 181 member B)
Type: protein-coding
Summary: family with sequence similarity 181 member B
Gene Ontology:
Pathways:
UniProt: A6NEQ2
Entrez ID: 220382
|
Does Knockout of MRFAP1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
MRFAP1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: MRFAP1 (Morf4 family associated protein 1)
Type: protein-coding
Summary: This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Gene Ontology: CC: cytoplasm, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q9Y605
Entrez ID: 93621
|
Does Knockout of MYL1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
MYL1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: MYL1 (myosin light chain 1)
Type: protein-coding
Summary: Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: muscle contraction, muscle filament sliding; MF: calcium ion binding, structural constituent of muscle; CC: contractile muscle fiber, cytosol, muscle myosin complex, myofibril, myosin II complex, myosin complex, sarcomere
Pathways: Airway smooth muscle cell contraction, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Endothelin Pathways, G13 Signaling Pathway, Muscle contraction, Regulation of Actin Cytoskeleton, Regulation of retinoblastoma protein, Striated Muscle Contraction, Striated Muscle Contraction Pathway
UniProt: P05976
Entrez ID: 4632
|
Does Knockout of NUP85 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
NUP85
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: NUP85 (nucleoporin 85)
Type: protein-coding
Summary: This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: chemotaxis, lamellipodium assembly, mRNA export from nucleus, mRNA transport, macrophage chemotaxis, nephron development, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, protein import into nucleus, protein transport; MF: protein binding, structural constituent of nuclear pore; CC: actin cytoskeleton, chromosome, chromosome, centromeric region, ciliary basal body, cytoplasm, cytoskeleton, cytosol, kinetochore, membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore outer ring, nucleoplasm, nucleus, spindle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, EML4 and NUDC in mitotic spindle formation, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Integrated breast cancer pathway, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q9BW27
Entrez ID: 79902
|
Does Knockout of C7orf25 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
C7orf25
|
response to virus
|
Huh-7 Cell
|
Gene: C7orf25 (chromosome 7 open reading frame 25)
Type: protein-coding
Summary: chromosome 7 open reading frame 25
Gene Ontology:
Pathways:
UniProt: Q9BPX7
Entrez ID: 79020
|
Does Knockout of PSMC4 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
PSMC4
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: PSMC4 (proteasome 26S subunit, ATPase 4)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: blastocyst development, positive regulation of proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis; MF: ATP binding, ATP hydrolysis activity, nucleotide binding, proteasome-activating activity, protein binding; CC: ciliary basal body, cytoplasm, cytosol, membrane, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Ciliary landscape, Epstein-Barr virus infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), regulation of eif-4e and p70s6 kinase, skeletal muscle hypertrophy is regulated via akt-mtor pathway
UniProt: P43686
Entrez ID: 5704
|
Does Knockout of BCL2L1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
BCL2L1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: BCL2L1 (BCL2 like 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: apoptotic mitochondrial changes, apoptotic process, apoptotic process in bone marrow cell, cellular response to alkaloid, cellular response to amino acid stimulus, cellular response to gamma radiation, defense response to virus, dendritic cell apoptotic process, dendritic cell proliferation, ectopic germ cell programmed cell death, endocytosis, epithelial cell proliferation, extrinsic apoptotic signaling pathway in absence of ligand, fertilization, germ cell development, hepatocyte apoptotic process, in utero embryonic development, intrinsic apoptotic signaling pathway in response to DNA damage, male gonad development, mitochondrion organization, negative regulation of anoikis, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of dendritic cell apoptotic process, negative regulation of developmental process, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of execution phase of apoptosis, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, negative regulation of neuron apoptotic process, negative regulation of protein localization to plasma membrane, negative regulation of release of cytochrome c from mitochondria, negative regulation of reproductive process, neuron apoptotic process, ovarian follicle development, positive regulation of apoptotic process, positive regulation of mononuclear cell proliferation, regulation of apoptotic process, regulation of apoptotic signaling pathway, regulation of cytokinesis, regulation of growth, regulation of intracellular signal transduction, regulation of mitochondrial membrane permeability, regulation of mitochondrial membrane potential, release of cytochrome c from mitochondria, response to cycloheximide, response to cytokine, response to other organism, response to radiation, response to stress, response to virus, spermatogenesis, transmembrane transport; MF: BH3 domain binding, channel activity, identical protein binding, protein binding, protein kinase binding; CC: Bcl-2 family protein complex, centrosome, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endoplasmic reticulum, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, nuclear membrane, nucleus, synapse, synaptic vesicle membrane
Pathways: ATF-2 transcription factor network, Acute viral myocarditis, Amyotrophic lateral sclerosis (ALS), Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis - multiple species - Homo sapiens (human), Apoptosis Modulation and Signaling, Autophagy - animal - Homo sapiens (human), CD40/CD40L signaling, Caspase Cascade in Apoptosis, Chronic myeloid leukemia - Homo sapiens (human), Class I PI3K signaling events mediated by Akt, Direct p53 effectors, EGFR Tyrosine Kinase Inhibitor Resistance, EPO signaling pathway, ErbB1 downstream signaling, Gastrin signaling pathway, Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex, Hepatitis C and Hepatocellular Carcinoma, Hepatocellular carcinoma - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Host-pathogen interaction of human coronaviruses - apoptosis, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), IL-18 signaling pathway, IL-3 signaling pathway, IL-6 signaling pathway, IL-7 signaling pathway, IL2 signaling events mediated by PI3K, IL2 signaling events mediated by STAT5, IL3-mediated signaling events, IL4-mediated signaling events, IL6-mediated signaling events, JAK-STAT signaling pathway - Homo sapiens (human), Leptin signaling pathway, Lipid and atherosclerosis - Homo sapiens (human), LncRNA-mediated mechanisms of therapeutic resistance, Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4), Measles - Homo sapiens (human), Mitophagy - animal - Homo sapiens (human), NF-kappa B signaling pathway - Homo sapiens (human), NOD-like receptor signaling pathway - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Photodynamic therapy-induced HIF-1 survival signaling, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of apoptosis by parathyroid hormone-related protein, Role of Calcineurin-dependent NFAT signaling in lymphocytes, Shigellosis - Homo sapiens (human), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), TNF-alpha signaling pathway, TNFalpha, Toxoplasmosis - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, apoptotic signaling in response to dna damage, il-2 receptor beta chain in t cell activation, opposing roles of aif in apoptosis and cell survival, p53 signaling pathway - Homo sapiens (human), ras signaling pathway, regulation of bad phosphorylation, role of mitochondria in apoptotic signaling
UniProt: Q07817
Entrez ID: 598
|
Does Knockout of ARSK in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
ARSK
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ARSK (arylsulfatase family member K)
Type: protein-coding
Summary: Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008].
Gene Ontology: MF: arylsulfatase activity, glucuronate-2-sulfatase activity, hydrolase activity, metal ion binding; CC: endoplasmic reticulum lumen, extracellular region, lysosome
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Metabolism of proteins, Post-translational protein modification, Sphingolipid metabolism, The activation of arylsulfatases
UniProt: Q6UWY0
Entrez ID: 153642
|
Does Knockout of NCMAP in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
NCMAP
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: NCMAP (non-compact myelin associated protein)
Type: protein-coding
Summary: Predicted to be a structural constituent of myelin sheath. Predicted to be involved in peripheral nervous system myelin formation and positive regulation of myelination. Predicted to be integral component of plasma membrane. Predicted to be active in Schmidt-Lanterman incisure and paranode region of axon. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: peripheral nervous system myelin formation, positive regulation of myelination, regulation of myelination; MF: structural constituent of myelin sheath; CC: Schmidt-Lanterman incisure, membrane, paranode region of axon, plasma membrane
Pathways:
UniProt: Q5T1S8
Entrez ID: 400746
|
Does Knockout of TUBGCP4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
TUBGCP4
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TUBGCP4 (tubulin gamma complex component 4)
Type: protein-coding
Summary: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, protein-containing complex assembly, spindle assembly; MF: gamma-tubulin binding, microtubule minus-end binding, protein binding, structural constituent of cytoskeleton; CC: centrosome, cytoplasm, cytoskeleton, cytosol, gamma-tubulin complex, gamma-tubulin ring complex, membrane, microtubule, microtubule cytoskeleton, microtubule organizing center, recycling endosome, spindle pole
Pathways: 15q11.2 copy number variation syndrome
UniProt: Q9UGJ1
Entrez ID: 27229
|
Does Knockout of NKX2-1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
NKX2-1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: NKX2-1 (NK2 homeobox 1)
Type: protein-coding
Summary: This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: GABAergic neuron differentiation, Leydig cell differentiation, anatomical structure formation involved in morphogenesis, animal organ development, animal organ morphogenesis, axon guidance, brain development, cell differentiation, cerebral cortex GABAergic interneuron differentiation, cerebral cortex cell migration, cerebral cortex neuron differentiation, club cell differentiation, developmental induction, endoderm development, epithelial tube branching involved in lung morphogenesis, forebrain development, forebrain dorsal/ventral pattern formation, forebrain neuron differentiation, forebrain neuron fate commitment, gene expression, globus pallidus development, hippocampus development, hypothalamus development, interneuron migration, locomotory behavior, lung development, lung saccule development, negative regulation of DNA-templated transcription, negative regulation of cell migration, negative regulation of epithelial to mesenchymal transition, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, neuron fate commitment, neuron migration, oligodendrocyte differentiation, pattern specification process, phospholipid metabolic process, pituitary gland development, positive regulation of DNA-templated transcription, positive regulation of circadian rhythm, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to hormone, rhythmic process, telencephalon cell migration, telencephalon development, thyroid gland development, type II pneumocyte differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, enzyme binding, intronic transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: chromatin, nucleoplasm, nucleus, transcription regulator complex
Pathways: Endoderm differentiation, FOXA2 and FOXA3 transcription factor networks, Pre-implantation embryo, Tgif disruption of Shh signaling
UniProt: P43699
Entrez ID: 7080
|
Does Knockout of GAMT in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
GAMT
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: GAMT (guanidinoacetate N-methyltransferase)
Type: protein-coding
Summary: The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: animal organ morphogenesis, creatine biosynthetic process, creatine metabolic process, methylation, muscle contraction, regulation of multicellular organism growth, spermatogenesis; MF: guanidinoacetate N-methyltransferase activity, methyltransferase activity, protein binding, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: 3-Phosphoglycerate dehydrogenase deficiency, Arginine and Proline Metabolism, Arginine and proline metabolism - Homo sapiens (human), Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency), Creatine deficiency, guanidinoacetate methyltransferase deficiency, Creatine metabolism, Dihydropyrimidine Dehydrogenase Deficiency (DHPD), Dimethylglycine Dehydrogenase Deficiency, Gene expression (Transcription), Generic Transcription Pathway, Glycine and Serine Metabolism, Glycine, serine and threonine metabolism - Homo sapiens (human), Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency), Hyperglycinemia, non-ketotic, Hyperornithinemia with gyrate atrophy (HOGA), Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome], Hyperprolinemia Type I, Hyperprolinemia Type II, L-arginine:glycine amidinotransferase deficiency, MECP2 and Associated Rett Syndrome, Metabolism, Metabolism of amino acids and derivatives, Non Ketotic Hyperglycinemia, Ornithine Aminotransferase Deficiency (OAT Deficiency), Prolidase Deficiency (PD), Prolinemia Type II, RNA Polymerase II Transcription, Sarcosinemia, Transcriptional Regulation by MECP2, creatine biosynthesis
UniProt: Q14353
Entrez ID: 2593
|
Does Knockout of FAM86B1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
FAM86B1
|
cell proliferation
|
Cancer Cell Line
|
Gene: FAM86B1 (family with sequence similarity 86 member B1 (gene/pseudogene))
Type: protein-coding
Summary: Predicted to enable methyltransferase activity. Predicted to be involved in methylation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity; CC: protein-containing complex
Pathways:
UniProt: Q8N7N1
Entrez ID: 85002
|
Does Knockout of MRPL50 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
MRPL50
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: MRPL50 (mitochondrial ribosomal protein L50)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: cytosol, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q8N5N7
Entrez ID: 54534
|
Does Knockout of SFT2D1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
SFT2D1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: SFT2D1 (SFT2 domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in protein transport and vesicle-mediated transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein transport, vesicle-mediated transport; CC: cytoplasm, endomembrane system, membrane
Pathways:
UniProt: Q8WV19
Entrez ID: 113402
|
Does Knockout of CDC23 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
CDC23
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: CDC23 (cell division cycle 23)
Type: protein-coding
Summary: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, metaphase/anaphase transition of mitotic cell cycle, mitotic cell cycle, mitotic metaphase chromosome alignment, positive regulation of mitotic metaphase/anaphase transition, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of exit from mitosis, regulation of meiotic cell cycle, regulation of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, ubiquitin-dependent protein catabolic process; MF: protein binding, ubiquitin-protein transferase activity; CC: anaphase-promoting complex, cytosol, nucleoplasm
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9UJX2
Entrez ID: 8697
|
Does Knockout of IL23A in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
IL23A
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: IL23A (interleukin 23 subunit alpha)
Type: protein-coding
Summary: This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, defense response to Gram-negative bacterium, defense response to virus, immune response, immune system process, inflammatory response, innate immune response, negative regulation of interleukin-10 production, positive regulation of NK T cell activation, positive regulation of NK T cell proliferation, positive regulation of T cell mediated cytotoxicity, positive regulation of T cell proliferation, positive regulation of T-helper 1 type immune response, positive regulation of T-helper 17 cell lineage commitment, positive regulation of T-helper 17 type immune response, positive regulation of activated T cell proliferation, positive regulation of alpha-beta T cell activation, positive regulation of defense response to virus by host, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of inflammatory response, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-17 production, positive regulation of leukocyte differentiation, positive regulation of macromolecule biosynthetic process, positive regulation of memory T cell differentiation, positive regulation of natural killer cell activation, positive regulation of natural killer cell proliferation, positive regulation of neutrophil chemotaxis, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of osteoclast differentiation, positive regulation of tissue remodeling, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, regulation of gene expression, regulation of primary metabolic process, tissue remodeling; MF: cytokine activity, interleukin-23 receptor binding, protein binding; CC: endoplasmic reticulum lumen, extracellular region, extracellular space, interleukin-23 complex
Pathways: ATF-2 transcription factor network, C-type lectin receptor signaling pathway - Homo sapiens (human), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Development and heterogeneity of the ILC family, IL23-mediated signaling events, Immune System, Inflammatory bowel disease - Homo sapiens (human), Interleukin-12 family signaling, Interleukin-23 signaling, Interleukin-4 and Interleukin-13 signaling, JAK-STAT signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pertussis - Homo sapiens (human), Rheumatoid arthritis - Homo sapiens (human), Signaling by Interleukins, Th17 cell differentiation - Homo sapiens (human), Tuberculosis - Homo sapiens (human)
UniProt: Q9NPF7
Entrez ID: 51561
|
Does Knockout of PRPF38A in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
PRPF38A
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: PRPF38A (pre-mRNA processing factor 38A)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: U2-type precatalytic spliceosome, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: MECP2 and Associated Rett Syndrome, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8NAV1
Entrez ID: 84950
|
Does Knockout of ANKRD7 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
ANKRD7
|
cell proliferation
|
T-lymphoma cell line
|
Gene: ANKRD7 (ankyrin repeat domain 7)
Type: protein-coding
Summary: Predicted to act upstream of or within blastocyst hatching. Located in centrosome and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: centrosome, nucleoplasm
Pathways:
UniProt: Q92527
Entrez ID: 56311
|
Does Knockout of NAT2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
NAT2
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: NAT2 (N-acetyltransferase 2)
Type: protein-coding
Summary: This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2). [provided by RefSeq, Sep 2019].
Gene Ontology: MF: N-hydroxyarylamine O-acetyltransferase activity, acetyltransferase activity, acyltransferase activity, arylamine N-acetyltransferase activity, protein binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Acetylation, Arylamine metabolism, Biological oxidations, Caffeine and Theobromine metabolism, Caffeine metabolism - Homo sapiens (human), Chemical carcinogenesis - Homo sapiens (human), Drug ADME, Drug metabolism - other enzymes - Homo sapiens (human), Metabolism, Metapathway biotransformation Phase I and II, Paracetamol ADME, Phase II - Conjugation of compounds
UniProt: P11245
Entrez ID: 10
|
Does Knockout of VDAC2 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
VDAC2
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: VDAC2 (voltage dependent anion channel 2)
Type: protein-coding
Summary: This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Gene Ontology: BP: binding of sperm to zona pellucida, lipid transport, mitochondrial outer membrane permeabilization, mitochondrial transmembrane transport, monoatomic anion transmembrane transport, monoatomic anion transport, monoatomic ion transport, phospholipid translocation, plasma membrane phospholipid scrambling, transmembrane transport; MF: ATP binding, ceramide binding, cholesterol binding, lipid binding, nucleotide binding, oxysterol binding, phosphatidylcholine binding, phospholipid scramblase activity, porin activity, protein binding, voltage-gated monoatomic anion channel activity, voltage-gated monoatomic ion channel activity; CC: acrosomal vesicle, membrane, membrane raft, mitochondrial membrane, mitochondrial nucleoid, mitochondrial outer membrane, mitochondrion, nucleus, pore complex, sperm midpiece
Pathways: Alzheimer disease - Homo sapiens (human), Autophagy, Calcium signaling pathway - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Cholesterol metabolism - Homo sapiens (human), Deubiquitination, Diabetic cardiomyopathy - Homo sapiens (human), Ferroptosis, Ferroptosis - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), Macroautophagy, Metabolism of proteins, Mitochondrial calcium ion transport, Mitophagy, NOD-like receptor signaling pathway - Homo sapiens (human), Necroptosis - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), PINK1-PRKN Mediated Mitophagy, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Selective autophagy, Spinocerebellar ataxia - Homo sapiens (human), Transport of small molecules, Ub-specific processing proteases, cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P45880
Entrez ID: 7417
|
Does Knockout of COL28A1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
COL28A1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: COL28A1 (collagen type XXVIII alpha 1 chain)
Type: protein-coding
Summary: COL28A1 belongs to a class of collagens containing von Willebrand factor (VWF; MIM 613160) type A (VWFA) domains (Veit et al., 2006 [PubMed 16330543]).[supplied by OMIM, Nov 2010].
Gene Ontology: MF: extracellular matrix structural constituent conferring tensile strength, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: basement membrane, collagen trimer, endoplasmic reticulum lumen, extracellular matrix, extracellular region
Pathways: Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen formation, Extracellular matrix organization, Protein digestion and absorption - Homo sapiens (human)
UniProt: Q2UY09
Entrez ID: 340267
|
Does Knockout of FAM86B1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
FAM86B1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: FAM86B1 (family with sequence similarity 86 member B1 (gene/pseudogene))
Type: protein-coding
Summary: Predicted to enable methyltransferase activity. Predicted to be involved in methylation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity; CC: protein-containing complex
Pathways:
UniProt: Q8N7N1
Entrez ID: 85002
|
Does Knockout of SLC9A6 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
SLC9A6
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: SLC9A6 (solute carrier family 9 member A6)
Type: protein-coding
Summary: This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].
Gene Ontology: BP: axon extension, dendrite extension, establishment of cell polarity, monoatomic cation transport, monoatomic ion transport, neuron projection morphogenesis, potassium ion transmembrane transport, proton transmembrane transport, regulation of intracellular pH, regulation of pH, sodium ion import across plasma membrane, sodium ion transport, transmembrane transport; MF: antiporter activity, identical protein binding, potassium:proton antiporter activity, protein binding, sodium:proton antiporter activity; CC: early endosome membrane, endoplasmic reticulum membrane, endosome, endosome membrane, late endosome membrane, membrane, mitochondrion, plasma membrane, recycling endosome, recycling endosome membrane
Pathways: Cardiac muscle contraction - Homo sapiens (human), Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH), Disease, Disorders of transmembrane transporters, Metal ion SLC transporters, SLC transporter disorders, SLC-mediated transmembrane transport, Sodium/Proton exchangers, Transport of small molecules
UniProt: Q92581
Entrez ID: 10479
|
Does Knockout of NOP53 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
NOP53
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: NOP53 (NOP53 ribosome biogenesis factor)
Type: protein-coding
Summary: Enables 5S rRNA binding activity; identical protein binding activity; and p53 binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; regulation of cellular protein metabolic process; and regulation of intracellular signal transduction. Located in cytosol; fibrillar center; and nucleoplasm. Colocalizes with rDNA heterochromatin. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to hypoxia, mitotic G2 DNA damage checkpoint signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein-containing complex assembly, negative regulation of signal transduction by p53 class mediator, negative regulation of transcription by RNA polymerase II, negative regulation of transcription of nucleolar large rRNA by RNA polymerase I, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K63-linked deubiquitination, protein localization to nucleolus, protein localization to nucleoplasm, protein stabilization, rRNA processing, regulation of RIG-I signaling pathway, regulation of aerobic respiration, regulation of apoptotic process, regulation of cell cycle, regulation of protein phosphorylation, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosome biogenesis; MF: 5S rRNA binding, RNA binding, identical protein binding, p53 binding, protein binding; CC: cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus, rDNA heterochromatin
Pathways:
UniProt: Q9NZM5
Entrez ID: 29997
|
Does Knockout of PCOLCE in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
PCOLCE
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: PCOLCE (procollagen C-endopeptidase enhancer)
Type: protein-coding
Summary: Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: collagen biosynthetic process, proteolysis; MF: collagen binding, extracellular matrix structural constituent, heparin binding, peptidase activator activity, protein binding; CC: extracellular exosome, extracellular matrix, extracellular region, extracellular space
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, Collagen formation, Crosslinking of collagen fibrils, Extracellular matrix organization
UniProt: Q15113
Entrez ID: 5118
|
Does Knockout of PDCD11 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
PDCD11
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: PDCD11 (programmed cell death 11)
Type: protein-coding
Summary: PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008].
Gene Ontology: BP: RNA processing, rRNA processing; MF: NF-kappaB binding, RNA binding, nucleic acid binding, protein binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q14690
Entrez ID: 22984
|
Does Knockout of NAE1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
NAE1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: NAE1 (NEDD8 activating enzyme E1 subunit 1)
Type: protein-coding
Summary: The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, mitotic DNA replication checkpoint signaling, neuron apoptotic process, protein neddylation, regulation of apoptotic process, regulation of neuron apoptotic process, regulation of postsynapse assembly, signal transduction; MF: NEDD8 activating enzyme activity, protein binding, protein heterodimerization activity, ubiquitin protein ligase binding, ubiquitin-like modifier activating enzyme activity; CC: cytoplasm, cytosol, glutamatergic synapse, membrane, plasma membrane, protein-containing complex
Pathways: Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Hijack of ubiquitination by SARS-CoV-2, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q13564
Entrez ID: 8883
|
Does Knockout of SAMM50 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
SAMM50
|
response to virus
|
Hepatoma Cell Line
|
Gene: SAMM50 (SAMM50 sorting and assembly machinery component)
Type: protein-coding
Summary: This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011].
Gene Ontology: BP: cristae formation, inner mitochondrial membrane organization, protein import into mitochondrial matrix, protein insertion into mitochondrial outer membrane; CC: MIB complex, SAM complex, cytoplasm, extracellular exosome, membrane, mitochondrial outer membrane, mitochondrion, outer membrane
Pathways: Cristae formation, Mitochondrial biogenesis, Mitochondrial protein import, Organelle biogenesis and maintenance, Protein localization, RAC2 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9Y512
Entrez ID: 25813
|
Does Knockout of MRPL35 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
MRPL35
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: MRPL35 (mitochondrial ribosomal protein L35)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9NZE8
Entrez ID: 51318
|
Does Knockout of SMYD3 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
SMYD3
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: SMYD3 (SET and MYND domain containing 3)
Type: protein-coding
Summary: This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: cellular response to dexamethasone stimulus, chromatin organization, establishment of protein localization, methylation, myotube cell development, nucleosome assembly, positive regulation of transcription by RNA polymerase II; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II complex binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, histone H3K36 dimethyltransferase activity, histone H3K4 trimethyltransferase activity, histone H4 methyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Histone Modifications, Lysine degradation - Homo sapiens (human), PKMTs methylate histone lysines
UniProt: Q9H7B4
Entrez ID: 64754
|
Does Knockout of KLRB1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
KLRB1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: KLRB1 (killer cell lectin like receptor B1)
Type: protein-coding
Summary: Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell surface receptor signaling pathway, regulation of natural killer cell mediated cytotoxicity; MF: carbohydrate binding, protein binding, signaling receptor activity, transmembrane signaling receptor activity; CC: cell surface, membrane, plasma membrane
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Malaria - Homo sapiens (human)
UniProt: Q12918
Entrez ID: 3820
|
Does Knockout of SPANXD in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
SPANXD
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: SPANXD (SPANX family member D)
Type: protein-coding
Summary: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014].
Gene Ontology: CC: cytoplasm, nucleus
Pathways:
UniProt: Q9BXN6
Entrez ID: 64648
|
Does Knockout of FGL2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
FGL2
|
cell proliferation
|
Cancer Cell Line
|
Gene: FGL2 (fibrinogen like 2)
Type: protein-coding
Summary: The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, negative regulation of defense response to virus, negative regulation of dendritic cell antigen processing and presentation, negative regulation of macrophage antigen processing and presentation, negative regulation of memory T cell differentiation; MF: extracellular matrix structural constituent, protein binding; CC: extracellular exosome, extracellular matrix, extracellular region, extracellular space, fibrinogen complex, ficolin-1-rich granule lumen
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q14314
Entrez ID: 10875
|
Does Knockout of ZNF812P in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
ZNF812P
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ZNF812P (zinc finger protein 812, pseudogene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of MYL12B in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
MYL12B
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: MYL12B (myosin light chain 12B)
Type: protein-coding
Summary: The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008].
Gene Ontology: MF: calcium ion binding, metal ion binding, myosin heavy chain binding, protein binding; CC: Z disc, apical part of cell, brush border, cell cortex, cytoplasm, cytosol, extracellular exosome, myofibril, myosin II complex, myosin complex, protein-containing complex, stress fiber
Pathways: Axon guidance, Axon guidance - Homo sapiens (human), Developmental Biology, EGFR1, EPH-Ephrin signaling, EPHA-mediated growth cone collapse, Focal Adhesion, Focal adhesion - Homo sapiens (human), Leukocyte transendothelial migration - Homo sapiens (human), Muscle contraction, Nervous system development, Platelet activation - Homo sapiens (human), RHO GTPase Effectors, RHO GTPases Activate ROCKs, RHO GTPases activate CIT, RHO GTPases activate PAKs, RHO GTPases activate PKNs, Regulation of actin cytoskeleton - Homo sapiens (human), Salmonella infection - Homo sapiens (human), Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Semaphorin interactions, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Smooth Muscle Contraction, Thyroid stimulating hormone (TSH) signaling pathway, Tight junction - Homo sapiens (human)
UniProt: O14950
Entrez ID: 103910
|
Does Knockout of MOK in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
MOK
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: MOK (MOK protein kinase)
Type: protein-coding
Summary: This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: intracellular signal transduction, protein phosphorylation, regulation of cell cycle, signal transduction; MF: ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell projection, ciliary base, cilium, cytoplasm, nucleus
Pathways:
UniProt: Q9UQ07
Entrez ID: 5891
|
Does Knockout of HSPB2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
HSPB2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: HSPB2 (heat shock protein family B (small) member 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: negative regulation of apoptotic process, protein refolding, response to heat, response to unfolded protein, somatic muscle development; MF: enzyme activator activity, protein binding, structural constituent of eye lens, unfolded protein binding; CC: cytoplasm, cytosol, nucleus
Pathways: IL-1 signaling pathway, Proteoglycans in cancer - Homo sapiens (human)
UniProt: Q16082
Entrez ID: 3316
|
Does Knockout of CAD in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
CAD
|
response to virus
|
Lung Cancer Cell Line
|
Gene: CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase)
Type: protein-coding
Summary: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: 'de novo' UMP biosynthetic process, 'de novo' pyrimidine nucleobase biosynthetic process, UDP biosynthetic process, UTP biosynthetic process, amino acid metabolic process, animal organ regeneration, cellular response to epidermal growth factor stimulus, cellular response to xenobiotic stimulus, citrulline biosynthetic process, female pregnancy, glutamine metabolic process, heart development, lactation, liver development, nucleobase-containing small molecule metabolic process, phosphate-containing compound metabolic process, pyrimidine nucleotide biosynthetic process, pyrimidine-containing compound biosynthetic process, response to amine, response to caffeine, response to cortisol, response to insulin, response to starvation, response to testosterone, xenobiotic metabolic process; MF: ATP binding, amino acid binding, aspartate binding, aspartate carbamoyltransferase activity, carbamoyl-phosphate synthase (ammonia) activity, carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, carboxyl- or carbamoyltransferase activity, catalytic activity, dihydroorotase activity, enzyme binding, glutaminase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, identical protein binding, ligase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, transferase activity, zinc ion binding; CC: cell projection, cytoplasm, cytosol, extracellular exosome, membrane, neuronal cell body, nuclear matrix, nucleus, protein-containing complex, terminal bouton
Pathways: 2-Hydroxyglutric Aciduria (D And L Form), 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency, Alanine, aspartate and glutamate metabolism - Homo sapiens (human), Amino Acid metabolism, Aspartate Metabolism, Beta Ureidopropionase Deficiency, Canavan Disease, Dihydropyrimidinase Deficiency, Endothelin Pathways, Glutamate Metabolism, Homocarnosinosis, Hyperinsulinism-Hyperammonemia Syndrome, Hypoacetylaspartia, MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Pyrimidine Metabolism, Pyrimidine biosynthesis, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), Succinic semialdehyde dehydrogenase deficiency, UMP Synthase Deiciency (Orotic Aciduria), UMP biosynthesis, Validated targets of C-MYC transcriptional activation, superpathway of pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, superpathway of pyrimidine ribonucleotides <i>de novo</i> biosynthesis
UniProt: P27708
Entrez ID: 790
|
Does Knockout of KRTAP15-1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
KRTAP15-1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: KRTAP15-1 (keratin associated protein 15-1)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: Q3LI76
Entrez ID: 254950
|
Does Knockout of GAMT in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
GAMT
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GAMT (guanidinoacetate N-methyltransferase)
Type: protein-coding
Summary: The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: animal organ morphogenesis, creatine biosynthetic process, creatine metabolic process, methylation, muscle contraction, regulation of multicellular organism growth, spermatogenesis; MF: guanidinoacetate N-methyltransferase activity, methyltransferase activity, protein binding, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: 3-Phosphoglycerate dehydrogenase deficiency, Arginine and Proline Metabolism, Arginine and proline metabolism - Homo sapiens (human), Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency), Creatine deficiency, guanidinoacetate methyltransferase deficiency, Creatine metabolism, Dihydropyrimidine Dehydrogenase Deficiency (DHPD), Dimethylglycine Dehydrogenase Deficiency, Gene expression (Transcription), Generic Transcription Pathway, Glycine and Serine Metabolism, Glycine, serine and threonine metabolism - Homo sapiens (human), Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency), Hyperglycinemia, non-ketotic, Hyperornithinemia with gyrate atrophy (HOGA), Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome], Hyperprolinemia Type I, Hyperprolinemia Type II, L-arginine:glycine amidinotransferase deficiency, MECP2 and Associated Rett Syndrome, Metabolism, Metabolism of amino acids and derivatives, Non Ketotic Hyperglycinemia, Ornithine Aminotransferase Deficiency (OAT Deficiency), Prolidase Deficiency (PD), Prolinemia Type II, RNA Polymerase II Transcription, Sarcosinemia, Transcriptional Regulation by MECP2, creatine biosynthesis
UniProt: Q14353
Entrez ID: 2593
|
Does Knockout of ENO4 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
ENO4
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: ENO4 (enolase 4)
Type: protein-coding
Summary: Predicted to enable phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process and regulation of vacuole fusion, non-autophagic. Predicted to act upstream of or within cilium organization and flagellated sperm motility. Predicted to be located in sperm principal piece. Predicted to be part of phosphopyruvate hydratase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: glycolytic process; MF: lyase activity, magnesium ion binding, phosphopyruvate hydratase activity; CC: phosphopyruvate hydratase complex
Pathways: Gluconeogenesis, Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), HIF-1 signaling pathway - Homo sapiens (human), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, RNA degradation - Homo sapiens (human)
UniProt: A6NNW6
Entrez ID: 387712
|
Does Knockout of HYOU1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
HYOU1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: HYOU1 (hypoxia up-regulated 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: cellular response to hypoxia, endoplasmic reticulum to Golgi vesicle-mediated transport, negative regulation of apoptotic process, negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway, protein folding, regulation of cellular response to stress, response to endoplasmic reticulum stress, response to ischemia, response to stress; MF: ATP binding, ATP-dependent protein folding chaperone, adenyl-nucleotide exchange factor activity, nucleotide binding, protein binding, protein-folding chaperone binding, unfolded protein binding; CC: endocytic vesicle lumen, endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, extracellular exosome, extracellular region, focal adhesion, membrane, mitochondrion, smooth endoplasmic reticulum
Pathways: Acetaminophen Metabolism Pathway, Binding and Uptake of Ligands by Scavenger Receptors, Cellular responses to stimuli, Cellular responses to stress, Etoposide Action Pathway, Etoposide Metabolism Pathway, IRE1alpha activates chaperones, Ibuprofen Action Pathway, Ibuprofen Metabolism Pathway, Irinotecan Action Pathway, Irinotecan Metabolism Pathway, Morphine Action Pathway, Morphine Metabolism Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Protein processing in endoplasmic reticulum - Homo sapiens (human), Retinol Metabolism, Scavenging by Class F Receptors, Sorafenib Metabolism Pathway, Unfolded Protein Response (UPR), VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport, Vitamin A Deficiency, XBP1(S) activates chaperone genes
UniProt: Q9Y4L1
Entrez ID: 10525
|
Does Knockout of TRMT61A in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,459
|
Knockout
|
TRMT61A
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: TRMT61A (tRNA methyltransferase 61A)
Type: protein-coding
Summary: Enables mRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation. Predicted to be located in nucleoplasm. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA processing, mRNA processing, methylation, tRNA methylation, tRNA processing; MF: mRNA (adenine-N1-)-methyltransferase activity, methyltransferase activity, protein binding, tRNA (adenine(58)-N1)-methyltransferase activity, transferase activity; CC: nucleoplasm, nucleus, tRNA (m1A) methyltransferase complex
Pathways: Metabolism of RNA, tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q96FX7
Entrez ID: 115708
|
Does Knockout of MTG2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
MTG2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: MTG2 (mitochondrial ribosome associated GTPase 2)
Type: protein-coding
Summary: Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: mitochondrial large ribosomal subunit assembly, regulation of mitochondrial translation, regulation of respiratory system process, regulation of translation, ribosome biogenesis; MF: GTP binding, GTPase activity, magnesium ion binding, metal ion binding, nucleotide binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrion
Pathways:
UniProt: Q9H4K7
Entrez ID: 26164
|
Does Knockout of TESC in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
TESC
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: TESC (tescalcin)
Type: protein-coding
Summary: Enables calcium ion binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of macromolecule metabolic process; and positive regulation of myeloid cell differentiation. Located in several cellular components, including cytosol; lamellipodium; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, cellular response to retinoic acid, male gonad development, megakaryocyte differentiation, negative regulation of cell population proliferation, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of granulocyte differentiation, positive regulation of megakaryocyte differentiation, positive regulation of sodium:proton antiporter activity, protein localization to plasma membrane, protein maturation, protein stabilization, protein transport, regulation of cell adhesion mediated by integrin; MF: calcium ion binding, magnesium ion binding, metal ion binding, phosphatase inhibitor activity, protein binding, protein homodimerization activity, protein kinase inhibitor activity; CC: cell projection, cytoplasm, cytosol, lamellipodium, membrane, nucleoplasm, nucleus, plasma membrane, ruffle, ruffle membrane
Pathways:
UniProt: Q96BS2
Entrez ID: 54997
|
Does Knockout of GOSR1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
GOSR1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: GOSR1 (golgi SNAP receptor complex member 1)
Type: protein-coding
Summary: This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, inter-Golgi cisterna vesicle-mediated transport, intra-Golgi vesicle-mediated transport, protein transport, retrograde transport, endosome to Golgi, vesicle fusion, vesicle-mediated transport; MF: SNAP receptor activity; CC: Golgi apparatus, Golgi medial cisterna, Golgi membrane, SNARE complex, cis-Golgi network, cytosol, membrane, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O95249
Entrez ID: 9527
|
Does Knockout of UBAP1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
UBAP1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: UBAP1 (ubiquitin associated protein 1)
Type: protein-coding
Summary: This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].
Gene Ontology: BP: membrane fission, multivesicular body assembly, protein transport, protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; MF: protein binding, ubiquitin binding; CC: ESCRT I complex, cytoplasm, cytosol, endosome, endosome membrane, plasma membrane
Pathways: Assembly Of The HIV Virion, Autophagy, Budding and maturation of HIV virion, Disease, Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Infectious disease, Late Phase of HIV Life Cycle, Late endosomal microautophagy, Membrane Trafficking, Membrane binding and targetting of GAG proteins, Synthesis And Processing Of GAG, GAGPOL Polyproteins, Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q9NZ09
Entrez ID: 51271
|
Does Knockout of SARS2 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
SARS2
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: SARS2 (seryl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: mitochondrial seryl-tRNA aminoacylation, seryl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, RNA binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, protein binding, serine-tRNA ligase activity, tRNA binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Metabolism of proteins, Mitochondrial tRNA aminoacylation, Translation, selenocysteine biosynthesis, tRNA Aminoacylation, tRNA charging
UniProt: Q9NP81
Entrez ID: 54938
|
Does Knockout of CENPU in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
CENPU
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: CENPU (centromere protein U)
Type: protein-coding
Summary: The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: chordate embryonic development, chromosome segregation; CC: centriolar satellite, chromosome, chromosome, centromeric region, cytoplasm, cytosol, inner kinetochore, kinetochore, nucleoplasm, nucleus
Pathways: PLK1 signaling events
UniProt: Q71F23
Entrez ID: 79682
|
Does Knockout of HSPA8 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
HSPA8
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: HSPA8 (heat shock protein family A (Hsp70) member 8)
Type: protein-coding
Summary: This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: ATP metabolic process, RNA splicing, autophagy, cellular response to starvation, cellular response to steroid hormone stimulus, cellular response to stress, chaperone-mediated autophagy, chaperone-mediated autophagy translocation complex disassembly, clathrin coat disassembly, mRNA processing, mRNA splicing, via spliceosome, membrane organization, negative regulation of DNA-templated transcription, negative regulation of NLRP3 inflammasome complex assembly, negative regulation of cellular component organization, negative regulation of signal transduction, negative regulation of supramolecular fiber organization, positive regulation of cell migration, protein catabolic process, protein folding, protein refolding, protein targeting to lysosome involved in chaperone-mediated autophagy, regulation of cytoplasmic pattern recognition receptor signaling pathway, regulation of protein complex stability, regulation of protein import, regulation of protein stability, regulation of protein-containing complex assembly, regulation of supramolecular fiber organization, response to unfolded protein, signal transduction; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein disaggregase activity, ATP-dependent protein folding chaperone, C3HC4-type RING finger domain binding, G protein-coupled receptor binding, MHC class II protein complex binding, RNA binding, cadherin binding, enzyme binding, heat shock protein binding, hydrolase activity, nucleotide binding, protein binding, protein folding chaperone, protein-folding chaperone binding, protein-macromolecule adaptor activity, receptor ligand activity, ubiquitin protein ligase binding, unfolded protein binding; CC: Prp19 complex, blood microparticle, clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane, cytoplasm, cytosol, extracellular exosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, focal adhesion, lumenal side of lysosomal membrane, lysosomal lumen, lysosomal membrane, lysosome, melanosome, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane, protein folding chaperone complex, ribonucleoprotein complex, secretory granule lumen, spliceosomal complex
Pathways: AUF1 (hnRNP D0) binds and destabilizes mRNA, AndrogenReceptor, Antigen processing and presentation - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Attenuation phase, Autophagy, Axon guidance, C-MYB transcription factor network, CHL1 interactions, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Chaperone Mediated Autophagy, Clathrin-mediated endocytosis, Cytokine Signaling in Immune system, Developmental Biology, Disease, Endocytosis - Homo sapiens (human), Estrogen signaling pathway - Homo sapiens (human), Exercise-induced Circadian Regulation, GABA synthesis, release, reuptake and degradation, Golgi Associated Vesicle Biogenesis, HSF1-dependent transactivation, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Immune System, Infectious disease, Innate Immune System, Interferon Signaling, Interleukin-4 and Interleukin-13 signaling, L1CAM interactions, Late endosomal microautophagy, Legionellosis - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Lipophagy, Longevity regulating pathway - multiple species - Homo sapiens (human), Lysosome Vesicle Biogenesis, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Macroautophagy, Measles - Homo sapiens (human), Membrane Trafficking, Metabolism of RNA, Metabolism of proteins, Nervous system development, Neuronal System, Neurotransmitter release cycle, Neutrophil degranulation, PKR-mediated signaling, Parkin-Ubiquitin Proteasomal System pathway, Post-translational protein modification, Prion disease - Homo sapiens (human), Processing of Capped Intron-Containing Pre-mRNA, Protein methylation, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of HSF1-mediated heat shock response, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of nuclear SMAD2/3 signaling, Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) genome replication, transcription and translation, Respiratory syncytial virus genome transcription, Selective autophagy, Signaling by Interleukins, Spliceosome - Homo sapiens (human), TGF_beta_Receptor, Toxoplasmosis - Homo sapiens (human), Transmission across Chemical Synapses, Vesicle-mediated transport, Viral Infection Pathways, mRNA Splicing, mRNA Splicing - Major Pathway, trans-Golgi Network Vesicle Budding
UniProt: P11142
Entrez ID: 3312
|
Does Knockout of GPN2 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
GPN2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: GPN2 (GPN-loop GTPase 2)
Type: protein-coding
Summary: Predicted to enable GTPase activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding
Pathways:
UniProt: Q9H9Y4
Entrez ID: 54707
|
Does Knockout of CEP44 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
CEP44
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CEP44 (centrosomal protein 44)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in centriole replication and centriole-centriole cohesion. Located in centriole; centrosome; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: centriole replication, centriole-centriole cohesion, centrosome cycle; MF: microtubule binding, protein binding; CC: centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, midbody, spindle pole
Pathways: Genes related to primary cilium development (based on CRISPR)
UniProt: Q9C0F1
Entrez ID: 80817
|
Does Knockout of AURKB in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
AURKB
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: AURKB (aurora kinase B)
Type: protein-coding
Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, cGAS/STING signaling pathway, cell cycle G2/M phase transition, cell division, cellular response to UV, cleavage furrow formation, midbody abscission, mitotic cell cycle, mitotic cytokinesis, mitotic cytokinesis checkpoint signaling, mitotic sister chromatid biorientation, mitotic spindle assembly, mitotic spindle midzone assembly, mitotic spindle organization, negative regulation of B cell apoptotic process, negative regulation of cGAS/STING signaling pathway, negative regulation of cytokinesis, negative regulation of innate immune response, negative regulation of transcription by RNA polymerase II, positive regulation of attachment of mitotic spindle microtubules to kinetochore, positive regulation of cell cycle process, positive regulation of cytokinesis, positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore, positive regulation of microtubule depolymerization, positive regulation of mitotic cell cycle spindle assembly checkpoint, positive regulation of mitotic cytokinesis, positive regulation of mitotic sister chromatid segregation, positive regulation of mitotic sister chromatid separation, positive regulation of telomere maintenance, post-translational protein modification, protein localization to kinetochore, regulation of chromosome segregation, regulation of cytokinesis, regulation of microtubule-based process, regulation of signal transduction by p53 class mediator, repair of mitotic kinetochore microtubule attachment defect, spindle organization; MF: ATP binding, kinase activity, kinase binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, transferase activity; CC: centrosome, chromocenter, chromosome, chromosome passenger complex, chromosome, centromeric region, condensed chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, microtubule cytoskeleton, midbody, mitotic spindle midzone, mitotic spindle pole, nucleoplasm, nucleus, spindle, spindle microtubule, spindle midzone, spindle pole
Pathways: APC/C-mediated degradation of cell cycle proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, ATM Signaling Network in Development and Disease, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Aurora A signaling, Aurora B signaling, Aurora C signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, FOXM1 transcription factor network, Gene expression (Transcription), Generic Transcription Pathway, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, Regulation of MECP2 expression and activity, Regulation of Microtubule Cytoskeleton, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of mitotic cell cycle, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional Regulation by MECP2, Transcriptional Regulation by TP53
UniProt: Q96GD4
Entrez ID: 9212
|
Does Knockout of BTBD9 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
BTBD9
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: BTBD9 (BTB domain containing 9)
Type: protein-coding
Summary: This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: adult locomotory behavior, circadian behavior, circadian sleep/wake cycle, non-REM sleep, long-term memory, modulation of chemical synaptic transmission, multicellular organismal-level iron ion homeostasis, regulation of synaptic vesicle endocytosis, sensory perception of temperature stimulus, serotonin metabolic process; CC: cytoplasm, glutamatergic synapse
Pathways:
UniProt: Q96Q07
Entrez ID: 114781
|
Does Knockout of SRR in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
SRR
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: SRR (serine racemase)
Type: protein-coding
Summary: Enables several functions, including L-serine ammonia-lyase activity; PDZ domain binding activity; and anion binding activity. Involved in pyruvate biosynthetic process; response to lipopolysaccharide; and serine family amino acid metabolic process. Located in cytoplasm and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: D-serine biosynthetic process, D-serine metabolic process, L-serine metabolic process, amino acid metabolic process, pyruvate biosynthetic process, response to ketamine, response to lipopolysaccharide, response to xenobiotic stimulus, serine family amino acid metabolic process; MF: ATP binding, D-serine ammonia-lyase activity, L-serine ammonia-lyase activity, PDZ domain binding, calcium ion binding, catalytic activity, glycine binding, identical protein binding, isomerase activity, lyase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, pyridoxal phosphate binding, serine racemase activity, threonine racemase activity; CC: apical part of cell, cytoplasm, cytosol, neuronal cell body
Pathways: 3-Phosphoglycerate dehydrogenase deficiency, Dihydropyrimidine Dehydrogenase Deficiency (DHPD), Dimethylglycine Dehydrogenase Deficiency, Glycine and Serine Metabolism, Glycine, serine and threonine metabolism - Homo sapiens (human), Hyperglycinemia, non-ketotic, Metabolism, Metabolism of amino acids and derivatives, Non Ketotic Hyperglycinemia, Sarcosinemia, Serine metabolism, serine and glycine biosynthesis
UniProt: Q9GZT4
Entrez ID: 63826
|
Does Knockout of CCNK in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
CCNK
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: CCNK (cyclin K)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, cell division, host-mediated suppression of viral genome replication, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of cell cycle, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of signal transduction, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein binding, protein kinase binding; CC: cyclin K-CDK12 complex, cyclin K-CDK13 complex, cyclin-dependent protein kinase holoenzyme complex, cyclin/CDK positive transcription elongation factor complex, nucleoplasm, nucleus
Pathways: Direct p53 effectors, Male infertility
UniProt: O75909
Entrez ID: 8812
|
Does Knockout of ABCF1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
ABCF1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: ABCF1 (ATP binding cassette subfamily F member 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: inflammatory response, positive regulation of translation, ribosome biogenesis, translation, translational initiation; MF: ATP binding, ATP hydrolysis activity, RNA binding, nucleotide binding, protein binding, ribosome binding, translation activator activity, translation factor activity, RNA binding; CC: cytoplasm, cytosol, membrane, nuclear envelope, nucleoplasm, nucleus
Pathways: ABC-family proteins mediated transport, IL-18 signaling pathway, Transport of small molecules
UniProt: Q8NE71
Entrez ID: 23
|
Does Knockout of SLC38A9 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
SLC38A9
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: SLC38A9 (solute carrier family 38 member 9)
Type: protein-coding
Summary: Enables L-arginine transmembrane transporter activity and L-leucine transmembrane transporter activity. Involved in amino acid transmembrane transport; cellular response to amino acid stimulus; and positive regulation of TOR signaling. Located in late endosome and lysosomal membrane. Is integral component of lysosomal membrane. Colocalizes with Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: L-arginine transmembrane transport, amino acid transmembrane transport, amino acid transport, asparagine transport, branched-chain amino acid transport, cellular response to amino acid stimulus, glutamine transport, positive regulation of TOR signaling, positive regulation of TORC1 signaling; MF: L-amino acid transmembrane transporter activity, L-arginine transmembrane transporter activity, L-asparagine transmembrane transporter activity, L-glutamine transmembrane transporter activity, L-leucine transmembrane transporter activity, amino acid transmembrane transporter activity, arginine binding, cholesterol binding, guanyl-nucleotide exchange factor activity, metal ion binding, protein binding, sterol sensor activity; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane
Pathways: Amino acids regulate mTORC1, Autophagy, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Homo sapiens (human), mTORC1-mediated signalling
UniProt: Q8NBW4
Entrez ID: 153129
|
Does Knockout of DYNLRB1 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
DYNLRB1
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: DYNLRB1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: microtubule-based movement, positive regulation of intracellular transport, visual behavior; MF: dynein intermediate chain binding, identical protein binding, microtubule motor activity, protein binding; CC: centrosome, ciliary tip, cilium, cytoplasm, cytoplasmic dynein complex, cytoskeleton, dynein complex, membrane, microtubule
Pathways: 3q29 copy number variation syndrome, Ciliary landscape, Cilium Assembly, Intraflagellar transport, Intraflagellar transport proteins binding to dynein, Organelle biogenesis and maintenance, Salmonella infection - Homo sapiens (human), TGF-beta receptor signaling, TGF_beta_Receptor
UniProt: Q9NP97
Entrez ID: 83658
|
Does Knockout of EIF5AL1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
EIF5AL1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: EIF5AL1 (eukaryotic translation initiation factor 5A like 1)
Type: protein-coding
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in positive regulation of translational elongation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of translational elongation, positive regulation of translational termination, translation, translational elongation; MF: RNA binding, ribosome binding, translation elongation factor activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways:
UniProt: Q6IS14
Entrez ID: 143244
|
Does Knockout of ZNF836 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
ZNF836
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: ZNF836 (zinc finger protein 836)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, zinc ion binding; CC: microtubule cytoskeleton, nucleolus, nucleus
Pathways: Herpes simplex virus 1 infection - Homo sapiens (human)
UniProt: Q6ZNA1
Entrez ID: 162962
|
Does Knockout of AXIN1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
AXIN1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: AXIN1 (axin 1)
Type: protein-coding
Summary: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: Wnt signaling pathway, apoptotic process, axial mesoderm development, axial mesoderm formation, beta-catenin destruction complex assembly, canonical Wnt signaling pathway, cell development, cytoplasmic microtubule organization, dorsal/ventral axis specification, dorsal/ventral pattern formation, epigenetic programming in the zygotic pronuclei, head development, in utero embryonic development, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of fat cell differentiation, negative regulation of gene expression, negative regulation of protein metabolic process, negative regulation of transcription elongation by RNA polymerase II, nucleocytoplasmic transport, positive regulation of JNK cascade, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein catabolic process, positive regulation of protein ubiquitination, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of ubiquitin-dependent protein catabolic process, post-anal tail morphogenesis, proteasome-mediated ubiquitin-dependent protein catabolic process, protein catabolic process, protein polyubiquitination, protein-containing complex assembly, regulation of canonical Wnt signaling pathway, sensory perception of sound; MF: I-SMAD binding, R-SMAD binding, SMAD binding, armadillo repeat domain binding, beta-catenin binding, enzyme binding, identical protein binding, molecular adaptor activity, p53 binding, protein binding, protein domain specific binding, protein homodimerization activity, protein kinase binding, protein serine/threonine kinase activator activity, protein serine/threonine kinase binding, signaling adaptor activity, ubiquitin protein ligase binding, ubiquitin-like ligase-substrate adaptor activity; CC: Wnt signalosome, beta-catenin destruction complex, cell cortex, cell periphery, cytoplasm, cytoplasmic vesicle, cytosol, lateral plasma membrane, membrane, microtubule cytoskeleton, nucleolus, nucleus, perinuclear region of cytoplasm, plasma membrane, protein-containing complex
Pathways: Alzheimer disease - Homo sapiens (human), Apoptosis-related network due to altered Notch3 in ovarian cancer, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Basal cell carcinoma - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, C-MYC pathway, Canonical Wnt signaling pathway, Chromosomal and microsatellite instability in colorectal cancer, Colorectal cancer - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), DNA damage response (only ATM dependent), Degradation of beta catenin, ESC Pluripotency Pathways, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Extracellular vesicle-mediated signaling in recipient cells, Gastric cancer - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), LncRNA involvement in canonical Wnt signaling and colorectal cancer, MAP3K1 role in promoting and blocking gonadal determination, Mesodermal commitment pathway, N-cadherin signaling events, Neural Crest Differentiation, Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Presenilin action in Notch and Wnt signaling, Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), TGF-beta Signaling Pathway, TGF-beta receptor signaling, The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, The influence of laminopathies on Wnt signaling, Wnt, Wnt Signaling Pathway, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages, multi-step regulation of transcription by pitx2, ncRNAs involved in Wnt signaling in hepatocellular carcinoma, segmentation clock, wnt signaling pathway
UniProt: O15169
Entrez ID: 8312
|
Does Knockout of HID1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
HID1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: HID1 (HID1 domain containing)
Type: protein-coding
Summary: Located in Golgi cisterna; cytoplasmic microtubule; and cytosol. Is extrinsic component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: insulin processing, response to glucose, secretory granule maturation, vacuole fusion, non-autophagic; CC: Golgi apparatus, Golgi medial cisterna, Golgi membrane, Golgi trans cisterna, cytoplasm, cytoplasmic microtubule, cytoplasmic side of Golgi membrane, cytosol, extracellular exosome, membrane
Pathways:
UniProt: Q8IV36
Entrez ID: 283987
|
Does Knockout of CORO2A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
CORO2A
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CORO2A (coronin 2A)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: actin binding, actin filament binding, protein binding; CC: brush border, transcription repressor complex
Pathways:
UniProt: Q92828
Entrez ID: 7464
|
Does Knockout of RPL13 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
RPL13
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: RPL13 (ribosomal protein L13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: blastocyst development, bone development, cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, membrane, nucleolus, nucleus, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P26373
Entrez ID: 6137
|
Does Knockout of DDX49 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
DDX49
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: DDX49 (DEAD-box helicase 49)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of cell growth and regulation of rRNA stability. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of cell growth, rRNA processing, regulation of rRNA stability; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, TCR, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y6V7
Entrez ID: 54555
|
Does Knockout of RPL22 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
RPL22
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPL22 (ribosomal protein L22)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: alpha-beta T cell differentiation, cytoplasmic translation, translation, translation at presynapse; MF: RNA binding, heparin binding, identical protein binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, glutamatergic synapse, nucleus, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P35268
Entrez ID: 6146
|
Does Knockout of SLC24A2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
SLC24A2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: SLC24A2 (solute carrier family 24 member 2)
Type: protein-coding
Summary: This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: calcium ion import, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, cellular response to high light intensity, cone photoresponse recovery, establishment of localization in cell, intracellular calcium ion homeostasis, learning, long-term synaptic depression, long-term synaptic potentiation, memory, monoatomic ion transmembrane transport, monoatomic ion transport, neuron cellular homeostasis, phototransduction, potassium ion transmembrane transport, potassium ion transport, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: antiporter activity, calcium channel activity, calcium, potassium:sodium antiporter activity, symporter activity; CC: membrane, photoreceptor inner segment, plasma membrane, postsynapse, presynapse
Pathways: Metal ion SLC transporters, SLC-mediated transmembrane transport, Sodium/Calcium exchangers, Transport of small molecules, Visual signal transduction: Cones
UniProt: Q9UI40
Entrez ID: 25769
|
Does Knockout of NUP88 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
NUP88
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: NUP88 (nucleoporin 88)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein import into nucleus, protein transport, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus; MF: protein binding, structural constituent of nuclear pore; CC: cytosol, nuclear envelope, nuclear pore, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q99567
Entrez ID: 4927
|
Does Knockout of ZYG11B in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
ZYG11B
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: ZYG11B (zyg-11 family member B, cell cycle regulator)
Type: protein-coding
Summary: Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways: Ciliary landscape, Hijack of ubiquitination by SARS-CoV-2
UniProt: Q9C0D3
Entrez ID: 79699
|
Does Knockout of MRPL33 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
MRPL33
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: MRPL33 (mitochondrial ribosomal protein L33)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; CC: cytoplasm, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: O75394
Entrez ID: 9553
|
Does Knockout of MIR563 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
MIR563
|
response to virus
|
Hepatoma Cell Line
|
Gene: MIR563 (microRNA 563)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 693148
|
Does Knockout of EXOSC10 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
EXOSC10
|
cell proliferation
|
Melanoma Cell Line
|
Gene: EXOSC10 (exosome component 10)
Type: protein-coding
Summary: Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA catabolic process; maturation of 5.8S rRNA; and negative regulation of telomere maintenance via telomerase. Located in cytosol; nuclear lumen; and transcriptionally active chromatin. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CUT catabolic process, DNA damage response, DNA repair, RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), histone mRNA catabolic process, maturation of 5.8S rRNA, negative regulation of telomere maintenance via telomerase, nuclear mRNA surveillance, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent antisense transcript catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent snRNA catabolic process, nuclear polyadenylation-dependent snoRNA catabolic process, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nucleobase-containing compound metabolic process, poly(A)-dependent snoRNA 3'-end processing, positive regulation of mRNA cis splicing, via spliceosome, rRNA processing, regulation of gene expression, regulation of nucleobase-containing compound metabolic process, regulation of telomerase RNA localization to Cajal body, ribosomal small subunit biogenesis; MF: 3'-5' exonuclease activity, 3'-5'-RNA exonuclease activity, RNA binding, RNA exonuclease activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, protein binding, single-stranded RNA binding, telomerase RNA binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, euchromatin, exosome (RNase complex), membrane, nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Homo sapiens (human), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q01780
Entrez ID: 5394
|
Does Activation of CHST4 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
CHST4
|
response to virus
|
Hepatoma Cell Line
|
Gene: CHST4 (carbohydrate sulfotransferase 4)
Type: protein-coding
Summary: This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: N-acetylglucosamine metabolic process, carbohydrate metabolic process, cell adhesion, cell-cell signaling, immune response, inflammatory response, positive regulation of leukocyte tethering or rolling, protein O-linked glycosylation via N-acetyl-galactosamine, protein sulfation, sulfur compound metabolic process; MF: N-acetylglucosamine 6-O-sulfotransferase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane, trans-Golgi network
Pathways: Glycosaminoglycan biosynthesis - keratan sulfate - Homo sapiens (human), Metabolism of proteins, Metapathway biotransformation Phase I and II, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification
UniProt: Q8NCG5
Entrez ID: 10164
|
Does Knockout of ZBTB38 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
ZBTB38
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: ZBTB38 (zinc finger and BTB domain containing 38)
Type: protein-coding
Summary: The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: DNA damage response, negative regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA replication, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, methyl-CpG binding, protein binding, protein homodimerization activity, zinc ion binding; CC: blood microparticle, chromosome, nucleoplasm, nucleus
Pathways:
UniProt: Q8NAP3
Entrez ID: 253461
|
Does Knockout of ATN1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
ATN1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: ATN1 (atrophin 1)
Type: protein-coding
Summary: Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: cell killing, cell migration, central nervous system development, determination of adult lifespan, maintenance of cell polarity, male gonad development, multicellular organism growth, negative regulation of transcription by RNA polymerase II, neuron apoptotic process, positive regulation of DNA-templated transcription, post-embryonic development, response to food, spermatogenesis; MF: protein binding, protein domain specific binding, transcription coactivator activity, transcription corepressor activity; CC: anchoring junction, cytoplasm, nuclear matrix, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, Regulation of PTEN gene transcription, Signal Transduction
UniProt: P54259
Entrez ID: 1822
|
Does Knockout of LTB4R2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
LTB4R2
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: LTB4R2 (leukotriene B4 receptor 2)
Type: protein-coding
Summary: Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within keratinocyte migration and signal transduction. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, chemotaxis, keratinocyte migration, leukotriene signaling pathway, negative regulation of adenylate cyclase activity, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, leukotriene B4 receptor activity, leukotriene receptor activity; CC: membrane, nucleoplasm, plasma membrane
Pathways: Calcium signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, Eicosanoid metabolism via lipooxygenases (LOX), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Other, Leukotriene receptors, Neuroactive ligand-receptor interaction - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q9NPC1
Entrez ID: 56413
|
Does Knockout of DNAJB1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
DNAJB1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1)
Type: protein-coding
Summary: This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cellular response to heat, forebrain development, negative regulation of inclusion body assembly, negative regulation of transcription by RNA polymerase II, positive regulation of protein folding, protein folding, regulation of cellular response to heat, response to unfolded protein; MF: ATPase activator activity, ATPase binding, Hsp70 protein binding, cadherin binding, protein binding, protein folding chaperone, protein-folding chaperone binding, transcription corepressor activity, transcription regulator inhibitor activity, unfolded protein binding; CC: cytoplasm, cytosol, dendritic spine, extracellular exosome, glutamatergic synapse, neuronal cell body, nucleolus, nucleoplasm, nucleus, postsynapse, postsynaptic density, sperm head
Pathways: Attenuation phase, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, HSF1-dependent transactivation, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Influenza A - Homo sapiens (human), MAPK family signaling cascades, MAPK6/MAPK4 signaling, NRF2 pathway, Nuclear Receptors Meta-Pathway, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of HSF1-mediated heat shock response, Signal Transduction, TCR
UniProt: P25685
Entrez ID: 3337
|
Does Knockout of CRCT1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
CRCT1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: CRCT1 (cysteine rich C-terminal 1)
Type: protein-coding
Summary: cysteine rich C-terminal 1
Gene Ontology:
Pathways:
UniProt: Q9UGL9
Entrez ID: 54544
|
Does Knockout of KIF26B in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
KIF26B
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: KIF26B (kinesin family member 26B)
Type: protein-coding
Summary: The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: establishment of cell polarity, microtubule-based movement, positive regulation of cell-cell adhesion, system development, ureteric bud invasion; MF: ATP binding, microtubule binding, microtubule motor activity, nucleotide binding; CC: cytoplasm, cytoskeleton, microtubule
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q2KJY2
Entrez ID: 55083
|
Does Knockout of RASA4 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
RASA4
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: RASA4 (RAS p21 protein activator 4)
Type: protein-coding
Summary: This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to calcium ion, intracellular signal transduction, negative regulation of GTPase activity, negative regulation of Ras protein signal transduction, regulation of intracellular signal transduction; MF: GTPase activator activity, metal ion binding, phospholipid binding, zinc ion binding; CC: cytoplasm, cytosol, membrane, plasma membrane
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of RAS by GAPs, Regulation of Ras family activation, Signal Transduction
UniProt: O43374
Entrez ID: 10156
|
Does Knockout of EMC1 in Colonic Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 1,387
|
Knockout
|
EMC1
|
response to virus
|
Colonic Adenocarcinoma Cell Line
|
Gene: EMC1 (ER membrane protein complex subunit 1)
Type: protein-coding
Summary: This gene encodes a single-pass type I transmembrane protein, which is a subunit of the endoplasmic reticulum membrane protein complex (EMC). Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2012].
Gene Ontology: BP: protein insertion into ER membrane by stop-transfer membrane-anchor sequence, tail-anchored membrane protein insertion into ER membrane; MF: membrane insertase activity, protein binding; CC: EMC complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, protein-containing complex
Pathways:
UniProt: Q8N766
Entrez ID: 23065
|
Does Knockout of RAC2 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
RAC2
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: RAC2 (Rac family small GTPase 2)
Type: protein-coding
Summary: This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, actin cytoskeleton organization, actin filament organization, bone resorption, cell population proliferation, cell projection assembly, chemotaxis, cortical cytoskeleton organization, erythrocyte enucleation, establishment or maintenance of cell polarity, lymphocyte aggregation, mast cell proliferation, positive regulation of lamellipodium assembly, positive regulation of mast cell proliferation, positive regulation of neutrophil chemotaxis, positive regulation of protein targeting to mitochondrion, regulation of T cell proliferation, regulation of actin cytoskeleton organization, regulation of cell shape, regulation of cell-substrate adhesion, regulation of hydrogen peroxide metabolic process, regulation of mast cell chemotaxis, regulation of mast cell degranulation, regulation of neutrophil migration, regulation of respiratory burst, respiratory burst, signal transduction, small GTPase-mediated signal transduction, superoxide anion generation; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding, protein kinase binding, protein kinase regulator activity; CC: NADPH oxidase complex, actin filament, cell projection, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endoplasmic reticulum membrane, extracellular exosome, focal adhesion, lamellipodium, membrane, mitochondrial outer membrane, nuclear envelope, phagocytic vesicle membrane, plasma membrane
Pathways: Acute viral myocarditis, Adherens junction - Homo sapiens (human), Axon guidance - Homo sapiens (human), B Cell Receptor Signaling Pathway, B cell receptor signaling pathway - Homo sapiens (human), Beta-catenin independent WNT signaling, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Choline metabolism in cancer - Homo sapiens (human), Chromosomal and microsatellite instability in colorectal cancer, Colorectal cancer - Homo sapiens (human), Constitutive Signaling by Aberrant PI3K in Cancer, DNA damage response (only ATM dependent), Diabetic cardiomyopathy - Homo sapiens (human), Disease, Diseases of signal transduction by growth factor receptors and second messengers, Fc epsilon RI signaling pathway - Homo sapiens (human), Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion, Focal adhesion - Homo sapiens (human), GPVI-mediated activation cascade, Hemostasis, Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), IL8- and CXCR2-mediated signaling events, Immune System, Innate Immune System, Insulin Signaling, Integrin-mediated Cell Adhesion, Intracellular signaling by second messengers, Leukocyte transendothelial migration - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Macrophage markers, Microglia Pathogen Phagocytosis Pathway, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Negative regulation of the PI3K/AKT network, Neutrophil extracellular trap formation - Homo sapiens (human), PCP/CE pathway, PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Platelet activation, signaling and aggregation, Prion disease - Homo sapiens (human), RAC2 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate NADPH Oxidases, ROS and RNS production in phagocytes, RalA downstream regulated genes, Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Sphingolipid signaling pathway - Homo sapiens (human), VEGF signaling pathway - Homo sapiens (human), Viral myocarditis - Homo sapiens (human), Wnt signaling pathway - Homo sapiens (human), Yersinia infection - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human)
UniProt: P15153
Entrez ID: 5880
|
Does Knockout of EXOC3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
EXOC3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: EXOC3 (exocyst complex component 3)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: exocyst localization, exocytosis, membrane fission, mitotic cytokinesis, protein transport, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; MF: SNARE binding, cadherin binding, protein binding; CC: Golgi apparatus, cell projection, cytoplasm, cytosol, exocyst, growth cone, membrane, midbody, neuron projection, perinuclear region of cytoplasm, secretory granule membrane
Pathways: Arf6 trafficking events, Cargo trafficking to the periciliary membrane, Ciliary landscape, Cilium Assembly, Insulin Pathway, Insulin processing, Membrane Trafficking, Metabolism of proteins, Organelle biogenesis and maintenance, Peptide hormone metabolism, Stabilization and expansion of the E-cadherin adherens junction, Translocation of SLC2A4 (GLUT4) to the plasma membrane, Vesicle-mediated transport, VxPx cargo-targeting to cilium
UniProt: O60645
Entrez ID: 11336
|
Does Knockout of TSPAN33 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
TSPAN33
|
cell proliferation
|
Cancer Cell Line
|
Gene: TSPAN33 (tetraspanin 33)
Type: protein-coding
Summary: Enables enzyme binding activity. Involved in pore complex assembly; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. Part of pore complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: pore complex assembly, protein localization to plasma membrane, protein maturation; MF: enzyme binding, protein binding; CC: adherens junction, anchoring junction, cell surface, cytoplasm, endoplasmic reticulum lumen, membrane, plasma membrane, pore complex, tetraspanin-enriched microdomain
Pathways: Amyloid fiber formation, Metabolism of proteins
UniProt: Q86UF1
Entrez ID: 340348
|
Does Knockout of STAU2 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
STAU2
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: STAU2 (staufen double-stranded RNA binding protein 2)
Type: protein-coding
Summary: Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
Gene Ontology: BP: anterograde dendritic transport of messenger ribonucleoprotein complex, cellular response to oxidative stress, eye morphogenesis, germ cell development, intracellular mRNA localization, positive regulation of dendritic spine morphogenesis, positive regulation of long-term synaptic depression, positive regulation of synapse assembly, protein localization to synapse, regulation of actin cytoskeleton organization, regulation of filopodium assembly; MF: Hsp70 protein binding, RNA binding, double-stranded RNA binding, kinesin binding, mRNA binding, mitogen-activated protein kinase binding, protein binding, ribosome binding; CC: axon, cytoplasm, cytoplasmic stress granule, dendrite, dendrite cytoplasm, dendritic shaft, endoplasmic reticulum, glutamatergic synapse, membrane, microtubule, neuron projection, neuronal cell body, nuclear membrane, nucleolus, nucleus, plasma membrane, postsynapse, protein-containing complex
Pathways:
UniProt: Q9NUL3
Entrez ID: 27067
|
Does Knockout of UFD1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
UFD1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: UFD1 (ubiquitin recognition factor in ER associated degradation 1)
Type: protein-coding
Summary: The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: ERAD pathway, cellular response to misfolded protein, negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, proteasome-mediated ubiquitin-dependent protein catabolic process, retrograde protein transport, ER to cytosol, skeletal system development, ubiquitin-dependent protein catabolic process; MF: K48-linked polyubiquitin modification-dependent protein binding, cysteine-type deubiquitinase activity, polyubiquitin modification-dependent protein binding, protein binding; CC: UFD1-NPL4 complex, VCP-NPL4-UFD1 AAA ATPase complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: 22q11.2 copy number variation syndrome, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, DNA Damage Bypass, DNA Repair, Deubiquitination, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Translation, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Ub-specific processing proteases
UniProt: Q92890
Entrez ID: 7353
|
Does Knockout of PPP1R12A in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
PPP1R12A
|
cell proliferation
|
Cancer Cell Line
|
Gene: PPP1R12A (protein phosphatase 1 regulatory subunit 12A)
Type: protein-coding
Summary: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].
Gene Ontology: BP: cellular response to xenobiotic stimulus, centrosome cycle, mitotic cell cycle, negative regulation of catalytic activity, neuron projection morphogenesis, positive regulation of transcription by RNA polymerase II, protein dephosphorylation, regulation of cell adhesion, regulation of establishment of endothelial barrier, regulation of nucleocytoplasmic transport, signal transduction; MF: 14-3-3 protein binding, enzyme inhibitor activity, myosin phosphatase regulator activity, phosphatase regulator activity, protein binding, protein kinase binding; CC: A band, PTW/PP1 phosphatase complex, Z disc, actin cytoskeleton, centrosome, contractile muscle fiber, cytoplasm, cytoskeleton, cytosol, focal adhesion, kinetochore, nucleolus, nucleoplasm, plasma membrane, stress fiber
Pathways: Cell Cycle, Cell Cycle, Mitotic, Focal Adhesion, Focal adhesion - Homo sapiens (human), G2/M Transition, Hippo-Merlin Signaling Dysregulation, Integrin-linked kinase signaling, Mitotic G2-G2/M phases, Oxytocin signaling pathway - Homo sapiens (human), PLK1 signaling events, Platelet activation - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RHO GTPase Effectors, RHO GTPases Activate ROCKs, RHO GTPases activate CIT, RHO GTPases activate PAKs, RHO GTPases activate PKNs, Regulation of Actin Cytoskeleton, Regulation of PLK1 Activity at G2/M Transition, Regulation of actin cytoskeleton - Homo sapiens (human), RhoA signaling pathway, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TNFalpha, Vascular smooth muscle contraction - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: O14974
Entrez ID: 4659
|
Does Knockout of EIF3F in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
EIF3F
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: EIF3F (eukaryotic translation initiation factor 3 subunit F)
Type: protein-coding
Summary: Enables deubiquitinase activity and identical protein binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; protein deubiquitination; and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: IRES-dependent viral translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, proteolysis, translation, translational initiation; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, identical protein binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, protein binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, membrane, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, VEGFA-VEGFR2 Signaling Pathway, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: O00303
Entrez ID: 8665
|
Does Knockout of MRPL13 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
MRPL13
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: MRPL13 (mitochondrial ribosomal protein L13)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, negative regulation of translation, translation; MF: RNA binding, mRNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9BYD1
Entrez ID: 28998
|
Does Knockout of FAM161A in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
FAM161A
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: FAM161A (FAM161 centrosomal protein A)
Type: protein-coding
Summary: This gene belongs to the FAM161 family. It is expressed mainly in the retina. Mouse studies suggested that this gene is involved in development of retinal progenitors during embryogenesis, and that its activity is restricted to mature photoreceptors after birth. Mutations in this gene cause autosomal recessive retinitis pigmentosa-28. Alternatively spliced transcript variants have been identified.[provided by RefSeq, Jan 2011].
Gene Ontology: BP: cell projection organization, cilium assembly, cilium organization, visual perception; MF: identical protein binding, microtubule binding, protein binding; CC: Golgi apparatus, astral microtubule, cell projection, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, mitotic spindle, mitotic spindle pole, nucleoplasm, photoreceptor connecting cilium, photoreceptor inner segment, spindle microtubule
Pathways: Ciliopathies
UniProt: Q3B820
Entrez ID: 84140
|
Does Inhibition of HMGN2 in Gastric tumor organoid model causally result in response to chemicals?
| 1
| 2,482
|
Inhibition
|
HMGN2
|
response to chemicals
|
Gastric tumor organoid model
|
Gene: HMGN2 (high mobility group nucleosomal binding domain 2)
Type: protein-coding
Summary: The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, chromatin organization, killing of cells of another organism; MF: DNA binding, RNA binding, chromatin binding, nucleosomal DNA binding, protein binding; CC: chromatin, cytoplasm, extracellular space, nucleus
Pathways: Prolactin
UniProt: P05204
Entrez ID: 3151
|
Does Knockout of GNL3L in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
GNL3L
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: GNL3L (G protein nucleolar 3 like)
Type: protein-coding
Summary: The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010].
Gene Ontology: BP: negative regulation of protein sumoylation, negative regulation of protein ubiquitination, negative regulation of telomere maintenance via telomerase, positive regulation of protein localization to chromosome, telomeric region, positive regulation of protein-containing complex assembly, regulation of protein stability, ribosome biogenesis; MF: GTP binding, RNA binding, nucleotide binding, protein binding; CC: cytosol, membrane, nucleolus, nucleoplasm, nucleus, telomerase holoenzyme complex
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q9NVN8
Entrez ID: 54552
|
Does Knockout of NOP56 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
NOP56
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: NOP56 (NOP56 ribonucleoprotein)
Type: protein-coding
Summary: Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, cadherin binding, histone methyltransferase binding, protein binding, snoRNA binding; CC: box C/D methylation guide snoRNP complex, cytoplasm, fibrillar center, membrane, nucleolus, nucleoplasm, nucleus, pre-snoRNP complex, ribonucleoprotein complex, small-subunit processome, sno(s)RNA-containing ribonucleoprotein complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Protein folding, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Spinocerebellar ataxia - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O00567
Entrez ID: 10528
|
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