prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of DEFB106B in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | DEFB106B | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: DEFB106B (defensin beta 106B)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins.... |
Does Knockout of PSEN1 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | PSEN1 | cell proliferation | Renal Cancer Cell Line | Gene: PSEN1 (presenilin 1)
Type: protein-coding
Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longe... |
Does Knockout of MEF2D in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | MEF2D | cell proliferation | Monocytic Leukemia Cell Line | Gene: MEF2D (myocyte enhancer factor 2D)
Type: protein-coding
Summary: This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by ... |
Does Knockout of MIR3143 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | MIR3143 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: MIR3143 (microRNA 3143)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of BICDL2 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | BICDL2 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: BICDL2 (BICD family like cargo adaptor 2)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and vesicle transport along microtubule. Predicted to be located in cytoplasm. [provided by Alliance of Genome... |
Does Knockout of FAM181B in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 1 | 1,996 | Knockout | FAM181B | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: FAM181B (family with sequence similarity 181 member B)
Type: protein-coding
Summary: family with sequence similarity 181 member B
Gene Ontology:
Pathways:
UniProt: A6NEQ2
Entrez ID: 220382 |
Does Knockout of MRFAP1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | MRFAP1 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: MRFAP1 (Morf4 family associated protein 1)
Type: protein-coding
Summary: This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a... |
Does Knockout of MYL1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | MYL1 | cell proliferation | Colonic Cancer Cell Line | Gene: MYL1 (myosin light chain 1)
Type: protein-coding
Summary: Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed ... |
Does Knockout of NUP85 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | NUP85 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: NUP85 (nucleoporin 85)
Type: protein-coding
Summary: This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The... |
Does Knockout of C7orf25 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | C7orf25 | response to virus | Huh-7 Cell | Gene: C7orf25 (chromosome 7 open reading frame 25)
Type: protein-coding
Summary: chromosome 7 open reading frame 25
Gene Ontology:
Pathways:
UniProt: Q9BPX7
Entrez ID: 79020 |
Does Knockout of PSMC4 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | PSMC4 | cell proliferation | Breast Cancer Cell Line | Gene: PSMC4 (proteasome 26S subunit, ATPase 4)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are co... |
Does Knockout of BCL2L1 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | BCL2L1 | cell proliferation | Colorectal Cancer Cell Line | Gene: BCL2L1 (BCL2 like 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by ... |
Does Knockout of ARSK in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | ARSK | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ARSK (arylsulfatase family member K)
Type: protein-coding
Summary: Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macr... |
Does Knockout of NCMAP in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | NCMAP | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: NCMAP (non-compact myelin associated protein)
Type: protein-coding
Summary: Predicted to be a structural constituent of myelin sheath. Predicted to be involved in peripheral nervous system myelin formation and positive regulation of myelination. Predicted to be integral component of plasma membran... |
Does Knockout of TUBGCP4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | TUBGCP4 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: TUBGCP4 (tubulin gamma complex component 4)
Type: protein-coding
Summary: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure ana... |
Does Knockout of NKX2-1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | NKX2-1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: NKX2-1 (NK2 homeobox 1)
Type: protein-coding
Summary: This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the ... |
Does Knockout of GAMT in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | GAMT | cell proliferation | Ovarian Cancer Cell Line | Gene: GAMT (guanidinoacetate N-methyltransferase)
Type: protein-coding
Summary: The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular... |
Does Knockout of FAM86B1 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | FAM86B1 | cell proliferation | Cancer Cell Line | Gene: FAM86B1 (family with sequence similarity 86 member B1 (gene/pseudogene))
Type: protein-coding
Summary: Predicted to enable methyltransferase activity. Predicted to be involved in methylation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: methyltransferase activit... |
Does Knockout of MRPL50 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | MRPL50 | cell proliferation | Colonic Cancer Cell Line | Gene: MRPL50 (mitochondrial ribosomal protein L50)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of SFT2D1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | SFT2D1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: SFT2D1 (SFT2 domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in protein transport and vesicle-mediated transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein transport, vesicle-... |
Does Knockout of CDC23 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | CDC23 | cell proliferation | Renal Cancer Cell Line | Gene: CDC23 (cell division cycle 23)
Type: protein-coding
Summary: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), w... |
Does Knockout of IL23A in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | IL23A | response to chemicals | Colorectal Cancer Cell Line | Gene: IL23A (interleukin 23 subunit alpha)
Type: protein-coding
Summary: This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1)... |
Does Knockout of PRPF38A in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | PRPF38A | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: PRPF38A (pre-mRNA processing factor 38A)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA sp... |
Does Knockout of ANKRD7 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | ANKRD7 | cell proliferation | T-lymphoma cell line | Gene: ANKRD7 (ankyrin repeat domain 7)
Type: protein-coding
Summary: Predicted to act upstream of or within blastocyst hatching. Located in centrosome and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: centrosome, nucleoplasm
Pathways:
Un... |
Does Knockout of NAT2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | NAT2 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: NAT2 (N-acetyltransferase 2)
Type: protein-coding
Summary: This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate in... |
Does Knockout of VDAC2 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | VDAC2 | cell proliferation | Neuroblastoma Cell Line | Gene: VDAC2 (voltage dependent anion channel 2)
Type: protein-coding
Summary: This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is al... |
Does Knockout of COL28A1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | COL28A1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: COL28A1 (collagen type XXVIII alpha 1 chain)
Type: protein-coding
Summary: COL28A1 belongs to a class of collagens containing von Willebrand factor (VWF; MIM 613160) type A (VWFA) domains (Veit et al., 2006 [PubMed 16330543]).[supplied by OMIM, Nov 2010].
Gene Ontology: MF: extracellular ... |
Does Knockout of FAM86B1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | FAM86B1 | cell proliferation | Colonic Cancer Cell Line | Gene: FAM86B1 (family with sequence similarity 86 member B1 (gene/pseudogene))
Type: protein-coding
Summary: Predicted to enable methyltransferase activity. Predicted to be involved in methylation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: methyltransferase activit... |
Does Knockout of SLC9A6 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | SLC9A6 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: SLC9A6 (solute carrier family 9 member A6)
Type: protein-coding
Summary: This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects i... |
Does Knockout of NOP53 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | NOP53 | cell proliferation | Colorectal Cancer Cell Line | Gene: NOP53 (NOP53 ribosome biogenesis factor)
Type: protein-coding
Summary: Enables 5S rRNA binding activity; identical protein binding activity; and p53 binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; regulation of cellular protein metabo... |
Does Knockout of PCOLCE in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | PCOLCE | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: PCOLCE (procollagen C-endopeptidase enhancer)
Type: protein-coding
Summary: Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are c... |
Does Knockout of PDCD11 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | PDCD11 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: PDCD11 (programmed cell death 11)
Type: protein-coding
Summary: PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008... |
Does Knockout of NAE1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | NAE1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: NAE1 (NEDD8 activating enzyme E1 subunit 1)
Type: protein-coding
Summary: The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis ... |
Does Knockout of SAMM50 in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | SAMM50 | response to virus | Hepatoma Cell Line | Gene: SAMM50 (SAMM50 sorting and assembly machinery component)
Type: protein-coding
Summary: This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membr... |
Does Knockout of MRPL35 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | MRPL35 | cell proliferation | Gastric Cancer Cell Line | Gene: MRPL35 (mitochondrial ribosomal protein L35)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of SMYD3 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | SMYD3 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: SMYD3 (SET and MYND domain containing 3)
Type: protein-coding
Summary: This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene... |
Does Knockout of KLRB1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | KLRB1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: KLRB1 (killer cell lectin like receptor B1)
Type: protein-coding
Summary: Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expr... |
Does Knockout of SPANXD in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | SPANXD | cell proliferation | Ewing's Sarcoma Cell Line | Gene: SPANXD (SPANX family member D)
Type: protein-coding
Summary: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa... |
Does Knockout of FGL2 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | FGL2 | cell proliferation | Cancer Cell Line | Gene: FGL2 (fibrinogen like 2)
Type: protein-coding
Summary: The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tet... |
Does Knockout of ZNF812P in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | ZNF812P | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ZNF812P (zinc finger protein 812, pseudogene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of MYL12B in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | MYL12B | cell proliferation | Breast Cancer Cell Line | Gene: MYL12B (myosin light chain 12B)
Type: protein-coding
Summary: The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwa... |
Does Knockout of MOK in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | MOK | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: MOK (MOK protein kinase)
Type: protein-coding
Summary: This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in g... |
Does Knockout of HSPB2 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | HSPB2 | cell proliferation | Medulloblastoma Cell Line | Gene: HSPB2 (heat shock protein family B (small) member 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentia... |
Does Knockout of CAD in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | CAD | response to virus | Lung Cancer Cell Line | Gene: CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase)
Type: protein-coding
Summary: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic acti... |
Does Knockout of KRTAP15-1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | KRTAP15-1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: KRTAP15-1 (keratin associated protein 15-1)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: Q... |
Does Knockout of GAMT in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | GAMT | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: GAMT (guanidinoacetate N-methyltransferase)
Type: protein-coding
Summary: The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular... |
Does Knockout of ENO4 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | ENO4 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: ENO4 (enolase 4)
Type: protein-coding
Summary: Predicted to enable phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process and regulation of vacuole fusion, non-autophagic. Predicted to act upstream of or within cilium organization and flagellated sperm motility. Predict... |
Does Knockout of HYOU1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | HYOU1 | cell proliferation | Medulloblastoma Cell Line | Gene: HYOU1 (hypoxia up-regulated 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accu... |
Does Knockout of TRMT61A in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 2,459 | Knockout | TRMT61A | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: TRMT61A (tRNA methyltransferase 61A)
Type: protein-coding
Summary: Enables mRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation. Predicted to be located in nucleoplasm. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. [provided... |
Does Knockout of MTG2 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | MTG2 | cell proliferation | Gastric Cancer Cell Line | Gene: MTG2 (mitochondrial ribosome associated GTPase 2)
Type: protein-coding
Summary: Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal tra... |
Does Knockout of TESC in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | TESC | cell proliferation | Colorectal Cancer Cell Line | Gene: TESC (tescalcin)
Type: protein-coding
Summary: Enables calcium ion binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of macromolecule metabolic process; and positive regulation of myeloid cell differentiation. Located in several cell... |
Does Knockout of GOSR1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | GOSR1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: GOSR1 (golgi SNAP receptor complex member 1)
Type: protein-coding
Summary: This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP re... |
Does Knockout of UBAP1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | UBAP1 | cell proliferation | Endometrial Cancer Cell Line | Gene: UBAP1 (ubiquitin associated protein 1)
Type: protein-coding
Summary: This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding doma... |
Does Knockout of SARS2 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | SARS2 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: SARS2 (seryl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis o... |
Does Knockout of CENPU in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | CENPU | cell proliferation | Breast Cancer Cell Line | Gene: CENPU (centromere protein U)
Type: protein-coding
Summary: The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence... |
Does Knockout of HSPA8 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | HSPA8 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: HSPA8 (heat shock protein family A (Hsp70) member 8)
Type: protein-coding
Summary: This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-s... |
Does Knockout of GPN2 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | GPN2 | cell proliferation | Glioblastoma Cell Line | Gene: GPN2 (GPN-loop GTPase 2)
Type: protein-coding
Summary: Predicted to enable GTPase activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding
Pathways:
UniProt: Q... |
Does Knockout of CEP44 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | CEP44 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: CEP44 (centrosomal protein 44)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in centriole replication and centriole-centriole cohesion. Located in centriole; centrosome; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP... |
Does Knockout of AURKB in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | AURKB | cell proliferation | Gastric Cancer Cell Line | Gene: AURKB (aurora kinase B)
Type: protein-coding
Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and... |
Does Knockout of BTBD9 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | BTBD9 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: BTBD9 (BTB domain containing 9)
Type: protein-coding
Summary: This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome a... |
Does Knockout of SRR in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | SRR | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: SRR (serine racemase)
Type: protein-coding
Summary: Enables several functions, including L-serine ammonia-lyase activity; PDZ domain binding activity; and anion binding activity. Involved in pyruvate biosynthetic process; response to lipopolysaccharide; and serine family amino acid metabolic proce... |
Does Knockout of CCNK in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | CCNK | cell proliferation | Breast Cancer Cell Line | Gene: CCNK (cyclin K)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of ... |
Does Knockout of ABCF1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | ABCF1 | cell proliferation | Bladder Carcinoma | Gene: ABCF1 (ATP binding cassette subfamily F member 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided int... |
Does Knockout of SLC38A9 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | SLC38A9 | cell proliferation | Hepatoma Cell Line | Gene: SLC38A9 (solute carrier family 38 member 9)
Type: protein-coding
Summary: Enables L-arginine transmembrane transporter activity and L-leucine transmembrane transporter activity. Involved in amino acid transmembrane transport; cellular response to amino acid stimulus; and positive regulation of TOR... |
Does Knockout of DYNLRB1 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | DYNLRB1 | response to chemicals | Monocytic Leukemia Cell Line | Gene: DYNLRB1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated i... |
Does Knockout of EIF5AL1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | EIF5AL1 | cell proliferation | Ovarian Cancer Cell Line | Gene: EIF5AL1 (eukaryotic translation initiation factor 5A like 1)
Type: protein-coding
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in positive regulation of translational elongation. Predicted to be located in endoplasmic reticulum membrane. Predicted t... |
Does Knockout of ZNF836 in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | ZNF836 | cell proliferation | Prostate Cancer Cell Line | Gene: ZNF836 (zinc finger protein 836)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by... |
Does Knockout of AXIN1 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | AXIN1 | cell proliferation | Glioblastoma Cell Line | Gene: AXIN1 (axin 1)
Type: protein-coding
Summary: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 b... |
Does Knockout of HID1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | HID1 | cell proliferation | Medulloblastoma Cell Line | Gene: HID1 (HID1 domain containing)
Type: protein-coding
Summary: Located in Golgi cisterna; cytoplasmic microtubule; and cytosol. Is extrinsic component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: insulin processing, response to glucose, secretory... |
Does Knockout of CORO2A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | CORO2A | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: CORO2A (coronin 2A)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprot... |
Does Knockout of RPL13 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | RPL13 | cell proliferation | Endometrial Cancer Cell Line | Gene: RPL13 (ribosomal protein L13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of DDX49 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | DDX49 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: DDX49 (DEAD-box helicase 49)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of cell growth and regulation of rRNA stability. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of RPL22 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | RPL22 | cell proliferation | Colonic Cancer Cell Line | Gene: RPL22 (ribosomal protein L22)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of SLC24A2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | SLC24A2 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: SLC24A2 (solute carrier family 24 member 2)
Type: protein-coding
Summary: This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in ... |
Does Knockout of NUP88 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | NUP88 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: NUP88 (nucleoporin 88)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the ma... |
Does Knockout of ZYG11B in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | ZYG11B | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: ZYG11B (zyg-11 family member B, cell cycle regulator)
Type: protein-coding
Summary: Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Part of Cul2-RING ubiquitin ligase comple... |
Does Knockout of MRPL33 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | MRPL33 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: MRPL33 (mitochondrial ribosomal protein L33)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of MIR563 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | MIR563 | response to virus | Hepatoma Cell Line | Gene: MIR563 (microRNA 563)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I... |
Does Knockout of EXOSC10 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | EXOSC10 | cell proliferation | Melanoma Cell Line | Gene: EXOSC10 (exosome component 10)
Type: protein-coding
Summary: Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA catabolic process; maturation of 5.8S rRNA; and negative regulation of telomere maintenance via telomerase. Located in cytosol; nuclear lumen; and trans... |
Does Activation of CHST4 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | CHST4 | response to virus | Hepatoma Cell Line | Gene: CHST4 (carbohydrate sulfotransferase 4)
Type: protein-coding
Summary: This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is local... |
Does Knockout of ZBTB38 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | ZBTB38 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: ZBTB38 (zinc finger and BTB domain containing 38)
Type: protein-coding
Summary: The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of th... |
Does Knockout of ATN1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | ATN1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: ATN1 (atrophin 1)
Type: protein-coding
Summary: Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a tr... |
Does Knockout of LTB4R2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | LTB4R2 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: LTB4R2 (leukotriene B4 receptor 2)
Type: protein-coding
Summary: Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within kerati... |
Does Knockout of DNAJB1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | DNAJB1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1)
Type: protein-coding
Summary: This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function a... |
Does Knockout of CRCT1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | CRCT1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: CRCT1 (cysteine rich C-terminal 1)
Type: protein-coding
Summary: cysteine rich C-terminal 1
Gene Ontology:
Pathways:
UniProt: Q9UGL9
Entrez ID: 54544 |
Does Knockout of KIF26B in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | KIF26B | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: KIF26B (kinesin family member 26B)
Type: protein-coding
Summary: The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some br... |
Does Knockout of RASA4 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | RASA4 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: RASA4 (RAS p21 protein activator 4)
Type: protein-coding
Summary: This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the tran... |
Does Knockout of EMC1 in Colonic Adenocarcinoma Cell Line causally result in response to virus? | 1 | 1,387 | Knockout | EMC1 | response to virus | Colonic Adenocarcinoma Cell Line | Gene: EMC1 (ER membrane protein complex subunit 1)
Type: protein-coding
Summary: This gene encodes a single-pass type I transmembrane protein, which is a subunit of the endoplasmic reticulum membrane protein complex (EMC). Multiple alternatively spliced transcript variants encoding different isoforms ha... |
Does Knockout of RAC2 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | RAC2 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: RAC2 (Rac family small GTPase 2)
Type: protein-coding
Summary: This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis,... |
Does Knockout of EXOC3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | EXOC3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: EXOC3 (exocyst complex component 3)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the c... |
Does Knockout of TSPAN33 in Cancer Cell Line causally result in cell proliferation? | 0 | 193 | Knockout | TSPAN33 | cell proliferation | Cancer Cell Line | Gene: TSPAN33 (tetraspanin 33)
Type: protein-coding
Summary: Enables enzyme binding activity. Involved in pore complex assembly; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. Part of pore complex. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of STAU2 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | STAU2 | cell proliferation | Hepatoma Cell Line | Gene: STAU2 (staufen double-stranded RNA binding protein 2)
Type: protein-coding
Summary: Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These prot... |
Does Knockout of UFD1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | UFD1 | cell proliferation | Colonic Cancer Cell Line | Gene: UFD1 (ubiquitin recognition factor in ER associated degradation 1)
Type: protein-coding
Summary: The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinat... |
Does Knockout of PPP1R12A in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | PPP1R12A | cell proliferation | Cancer Cell Line | Gene: PPP1R12A (protein phosphatase 1 regulatory subunit 12A)
Type: protein-coding
Summary: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and ... |
Does Knockout of EIF3F in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | EIF3F | cell proliferation | Monocytic Leukemia Cell Line | Gene: EIF3F (eukaryotic translation initiation factor 3 subunit F)
Type: protein-coding
Summary: Enables deubiquitinase activity and identical protein binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; protein deubiquitinat... |
Does Knockout of MRPL13 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | MRPL13 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: MRPL13 (mitochondrial ribosomal protein L13)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of FAM161A in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | FAM161A | cell proliferation | Monocytic Leukemia Cell Line | Gene: FAM161A (FAM161 centrosomal protein A)
Type: protein-coding
Summary: This gene belongs to the FAM161 family. It is expressed mainly in the retina. Mouse studies suggested that this gene is involved in development of retinal progenitors during embryogenesis, and that its activity is restricted to m... |
Does Inhibition of HMGN2 in Gastric tumor organoid model causally result in response to chemicals? | 1 | 2,482 | Inhibition | HMGN2 | response to chemicals | Gastric tumor organoid model | Gene: HMGN2 (high mobility group nucleosomal binding domain 2)
Type: protein-coding
Summary: The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin conf... |
Does Knockout of GNL3L in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | GNL3L | cell proliferation | Colorectal Cancer Cell Line | Gene: GNL3L (G protein nucleolar 3 like)
Type: protein-coding
Summary: The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided ... |
Does Knockout of NOP56 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | NOP56 | cell proliferation | Medulloblastoma Cell Line | Gene: NOP56 (NOP56 ribonucleoprotein)
Type: protein-coding
Summary: Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded b... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.