prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Arl4a in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Arl4a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Arl4a (ADP-ribosylation factor-like 4A)
Type: protein-coding
Summary: Predicted to enable GTP binding activity. Acts upstream of or within brown fat cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; jaw bone; paraxial mesenchyme; skeletal musculature; and testis. Orthologous to human ARL4A (ARF like GTPase 4A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: brown fat cell differentiation, intracellular protein transport, vesicle-mediated transport; MF: GTP binding, GTPase activity, nucleotide binding; CC: cytoplasm, cytosol, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: P61213
Entrez ID: 11861
|
Does Knockout of Camk1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Camk1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Camk1 (calcium/calmodulin-dependent protein kinase I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, intracellular signal transduction, nervous system development, nucleocytoplasmic transport, positive regulation of dendritic spine development, positive regulation of muscle cell differentiation, positive regulation of neuron projection development, positive regulation of protein export from nucleus, positive regulation of synapse structural plasticity, positive regulation of syncytium formation by plasma membrane fusion, positive regulation of transcription by RNA polymerase II, regulation of muscle cell differentiation, regulation of protein localization, regulation of synapse organization, signal transduction; MF: ATP binding, calcium/calmodulin-dependent protein kinase activity, calmodulin binding, catalytic activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, glutamatergic synapse, nucleus, postsynaptic density
Pathways: Activation of NMDA receptors and postsynaptic events, Activation of RAC1 downstream of NMDARs, Aldosterone synthesis and secretion - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Glioma - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Oxytocin signaling pathway - Mus musculus (mouse), Post NMDA receptor activation events, Transmission across Chemical Synapses
UniProt: Q91YS8
Entrez ID: 52163
|
Does Knockout of Kat8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Kat8
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Kat8 (K(lysine) acetyltransferase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, dosage compensation by inactivation of X chromosome, epigenetic regulation of gene expression, epithelial to mesenchymal transition, germ cell development, hemopoiesis, membraneless organelle assembly, myeloid cell differentiation, negative regulation of DNA-templated transcription, negative regulation of epithelial to mesenchymal transition, negative regulation of macromolecule biosynthetic process, negative regulation of multicellular organismal process, negative regulation of type I interferon production, neurogenesis, oogenesis, positive regulation of DNA-templated transcription, positive regulation of epithelial to mesenchymal transition, positive regulation of skeletal muscle satellite cell differentiation, positive regulation of transcription initiation by RNA polymerase II, positive regulation of type I interferon production, post-embryonic hemopoiesis, regulation of DNA-templated transcription, regulation of autophagy, regulation of cell differentiation, regulation of mRNA processing, regulation of mitochondrial transcription, transcription initiation-coupled chromatin remodeling; MF: RNA polymerase II-specific DNA-binding transcription factor binding, acetyltransferase activity, acyltransferase activity, chromatin binding, enzyme binding, histone H4 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone acetyltransferase activity, metal ion binding, promoter-specific chromatin binding, protein binding, protein propionyltransferase activity, protein-lysine-acetyltransferase activity, transcription coactivator activity, transferase activity, zinc ion binding; CC: MLL1 complex, MSL complex, NSL complex, NuA4 histone acetyltransferase complex, chromosome, histone acetyltransferase complex, kinetochore, mitochondrion, nuclear lumen, nuclear matrix, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones
UniProt: Q9D1P2
Entrez ID: 67773
|
Does Knockout of Rpl23 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Rpl23
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rpl23 (ribosomal protein L23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1 to G0 transition, cellular response to actinomycin D, cytoplasmic translation, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of signal transduction by p53 class mediator, protein stabilization, protein-DNA complex disassembly, regulation of G1 to G0 transition, translation, translation at postsynapse, translation at presynapse; MF: large ribosomal subunit rRNA binding, protein binding, structural constituent of ribosome, transcription coactivator binding, ubiquitin ligase inhibitor activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, nucleolus, nucleoplasm, postsynapse, postsynaptic density, presynapse, protein-containing complex, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62830
Entrez ID: 65019
|
Does Knockout of Cd302 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Cd302
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cd302 (CD302 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phagocytosis; MF: carbohydrate binding, signaling receptor activity; CC: cell cortex, cell projection, cytoplasm, filopodium, membrane, microvillus
Pathways:
UniProt: Q9DCG2
Entrez ID: 66205
|
Does Knockout of BC005537 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
BC005537
|
protein/peptide accumulation
|
Mouse cell
|
Gene: BC005537 (cDNA sequence BC005537)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q99LU8
Entrez ID: 79555
|
Does Knockout of Tysnd1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Tysnd1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tysnd1 (trypsin domain containing 1)
Type: protein-coding
Summary: This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: protein processing, proteolysis, regulation of fatty acid beta-oxidation; MF: hydrolase activity, identical protein binding, peptidase activity, protease binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: peroxisomal matrix, peroxisome
Pathways: Peroxisomal protein import, Protein localization, TYSND1 cleaves peroxisomal proteins
UniProt: Q9DBA6
Entrez ID: 71767
|
Does Knockout of Nars2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Nars2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nars2 (asparaginyl-tRNA synthetase 2 (mitochondrial)(putative))
Type: protein-coding
Summary: Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in embryo; extraembryonic component; and primitive endoderm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: asparaginyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, asparagine-tRNA ligase activity, ligase activity, nucleic acid binding, nucleotide binding; CC: cytosol, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8BGV0
Entrez ID: 244141
|
Does Knockout of Szt2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Szt2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Szt2 (SZT2 subunit of KICSTOR complex)
Type: protein-coding
Summary: Involved in negative regulation of TORC1 signaling; regulation of superoxide dismutase activity; and response to nutrient levels. Acts upstream of or within central nervous system development; pigmentation; and post-embryonic development. Located in peroxisome. Is expressed in several structures, including central nervous system; heart; lung; metanephros; and spleen. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 18. Orthologous to human SZT2 (SZT2 subunit of KICSTOR complex). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to amino acid starvation, cellular response to glucose starvation, central nervous system development, corpus callosum morphogenesis, negative regulation of TORC1 signaling, pigmentation, post-embryonic development, protein localization to lysosome, regulation of superoxide dismutase activity, response to nutrient levels; CC: GATOR1 complex, GATOR2 complex, KICSTOR complex, lysosomal membrane, lysosome, membrane, peroxisome
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress
UniProt: A2A9C3
Entrez ID: 230676
|
Does Knockout of Izumo3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Izumo3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Izumo3 (IZUMO family member 3)
Type: protein-coding
Summary: Enables protein homodimerization activity. Involved in acrosome assembly. Located in inner acrosomal membrane. Orthologous to human IZUMO3 (IZUMO family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: acrosome assembly, biological_process, cell differentiation, spermatogenesis; MF: molecular_function, protein homodimerization activity; CC: cellular_component, cytoplasmic vesicle, inner acrosomal membrane, membrane, plasma membrane
Pathways: Acrosome Reaction and Sperm:Oocyte Membrane Binding, Fertilization, Reproduction
UniProt: A6PWV3
Entrez ID: 69314
|
Does Knockout of Eri2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Eri2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Eri2 (exoribonuclease 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: 3'-5'-RNA exonuclease activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, zinc ion binding
Pathways:
UniProt: Q5BKS4
Entrez ID: 71151
|
Does Knockout of Mir16-1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mir16-1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mir16-1 (microRNA 16-1)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: BMP signaling pathway, cellular response to leukemia inhibitory factor, miRNA-mediated post-transcriptional gene silencing, ossification, regulation of cell cycle, response to bacterium, response to oxygen levels, response to wounding, sensory perception of sound; CC: RISC complex, RNAi effector complex, extracellular exosome
Pathways: MicroRNAs in cancer - Mus musculus (mouse)
UniProt:
Entrez ID: 387134
|
Does Knockout of Tmem141 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Tmem141
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmem141 (transmembrane protein 141)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2AJB2
Entrez ID: 51875
|
Does Knockout of Tesmin in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Tesmin
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tesmin (testis expressed metallothionein like)
Type: protein-coding
Summary: Involved in male meiotic nuclear division and spermatogenesis. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including adrenal gland; gonad; heart; liver; and lung. Orthologous to human TESMIN (testis expressed metallothionein like protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, male meiotic nuclear division, meiotic cell cycle, regulation of DNA-templated transcription, spermatogenesis; CC: cytoplasm, male germ cell nucleus, nucleus
Pathways:
UniProt: Q9WTJ6
Entrez ID: 17771
|
Does Knockout of Btbd35f13 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Btbd35f13
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Btbd35f13 (BTB domain containing 35, family member 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, germ cell development
Pathways:
UniProt: B8JKF6
Entrez ID: 100040722
|
Does Knockout of Shank1 in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,197
|
Knockout
|
Shank1
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Shank1 (SH3 and multiple ankyrin repeat domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMPA selective glutamate receptor signaling pathway, adult behavior, associative learning, cell differentiation, dendritic spine morphogenesis, determination of affect, habituation, long-term memory, maintenance of postsynaptic density structure, memory, modulation of chemical synaptic transmission, negative regulation of actin filament bundle assembly, nervous system development, neuromuscular process controlling balance, olfactory behavior, positive regulation of dendritic spine development, positive regulation of excitatory postsynaptic potential, protein localization to synapse, protein-containing complex assembly, righting reflex, social behavior, synapse maturation, synapse organization, vocalization behavior; MF: G protein-coupled receptor binding, SH3 domain binding, ankyrin repeat binding, identical protein binding, ionotropic glutamate receptor binding, protein binding, protein-containing complex binding, scaffold protein binding, signaling receptor complex adaptor activity, somatostatin receptor binding, structural constituent of postsynaptic density, synaptic receptor adaptor activity; CC: Schaffer collateral - CA1 synapse, cytoplasm, dendrite, dendritic spine, excitatory synapse, glutamatergic synapse, membrane, neuron projection, plasma membrane, postsynaptic density, postsynaptic membrane, synapse
Pathways: Glutamatergic synapse - Mus musculus (mouse), Neurexins and neuroligins, Neuronal System, Protein-protein interactions at synapses
UniProt: D3YZU1
Entrez ID: 243961
|
Does Knockout of Ecsit in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Ecsit
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ecsit (ECSIT signalling integrator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, cell surface receptor protein serine/threonine kinase signaling pathway, immune system process, innate immune response, mesoderm formation, non-canonical NF-kappaB signal transduction, regulation of oxidoreductase activity, regulation of protein complex stability, regulation of transcription by RNA polymerase II, toll-like receptor 4 signaling pathway; MF: DNA-binding transcription factor activity, chromatin binding, molecular adaptor activity, protein binding; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, transcription regulator complex
Pathways: MAPK signaling pathway - Mus musculus (mouse)
UniProt: Q9QZH6
Entrez ID: 26940
|
Does Knockout of Alox8 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Alox8
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Alox8 (arachidonate 8-lipoxygenase)
Type: protein-coding
Summary: This gene belongs to the lipoxygenase (LOX) gene family whose members encode enzymes that catalyze the addition of molecular oxygen to polyunsaturated fatty acids (PUFAs) to yield fatty acid hydroperoxides. The encoded enzyme preferentially metabolizes arachidonic acid to yield 8-hydroxyeicosatetraenoic acid (8-HETE), while metabolizing linoleic acid less efficiently. The gene may also function as a tumor suppressor. This gene is located in a cluster of related genes that spans approximately 75 kilobases on chromosome 11. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: arachidonate metabolic process, cannabinoid biosynthetic process, endocannabinoid signaling pathway, hepoxilin biosynthetic process, linoleic acid metabolic process, lipid metabolic process, lipid oxidation, lipoxin A4 biosynthetic process, lipoxygenase pathway, negative regulation of cell cycle, negative regulation of cell population proliferation, negative regulation of growth, phospholipid metabolic process, positive regulation of chemokine production, positive regulation of keratinocyte differentiation, positive regulation of macrophage derived foam cell differentiation, positive regulation of peroxisome proliferator activated receptor signaling pathway; MF: arachidonate 15-lipoxygenase activity, arachidonate 8(S)-lipoxygenase activity, calcium ion binding, dioxygenase activity, iron ion binding, linoleate 13S-lipoxygenase activity, linoleate 9S-lipoxygenase activity, lipid binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; CC: adherens junction, cytoplasm, cytoskeleton, cytosol, focal adhesion, membrane, nucleus, plasma membrane
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Serotonergic synapse - Mus musculus (mouse), Synthesis of 15-eicosatetraenoic acid derivatives
UniProt: O35936
Entrez ID: 11688
|
Does Knockout of Ube2m in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Ube2m
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ube2m (ubiquitin-conjugating enzyme E2M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of neuron apoptotic process, protein modification process, protein neddylation, regulation of postsynapse assembly; MF: ATP binding, NEDD8 conjugating enzyme activity, NEDD8 transferase activity, nucleotide binding, transferase activity, ubiquitin-protein transferase activity; CC: cytosol, glutamatergic synapse, nucleus, postsynapse, presynapse
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Immune System, Innate Immune System, Metabolism of proteins, NIK-->noncanonical NF-kB signaling, Neddylation, Post-translational protein modification, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, TNFR2 non-canonical NF-kB pathway, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P61082
Entrez ID: 22192
|
Does Knockout of Ube2w in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Ube2w
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ube2w (ubiquitin-conjugating enzyme E2W (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, TORC1 signaling, antiviral innate immune response, cellular response to misfolded protein, cellular response to nutrient levels, negative regulation of TORC1 signaling, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein monoubiquitination, protein polyubiquitination, protein quality control for misfolded or incompletely synthesized proteins, protein ubiquitination; MF: ATP binding, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity; CC: nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8VDW4
Entrez ID: 66799
|
Does Knockout of Tubgcp3 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Tubgcp3
|
response to virus
|
Microglial Cell Line
|
Gene: Tubgcp3 (tubulin, gamma complex component 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, spindle assembly; MF: gamma-tubulin binding, microtubule minus-end binding; CC: centriole, centrosome, cytoplasm, cytoskeleton, gamma-tubulin complex, microtubule, microtubule organizing center, polar microtubule, spindle pole
Pathways: Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes
UniProt: P58854
Entrez ID: 259279
|
Does Knockout of Ndufa5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Ndufa5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ndufa5 (NADH:ubiquinone oxidoreductase subunit A5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis, respiratory electron transport chain; CC: membrane, mitochondrial inner membrane, mitochondrion, protein-containing complex, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RHO GTPase cycle, RHOG GTPase cycle, Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CPP6
Entrez ID: 68202
|
Does Knockout of Clstn2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,174
|
Knockout
|
Clstn2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Clstn2 (calsyntenin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: associative learning, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, inhibitory synapse assembly, positive regulation of synapse assembly, positive regulation of synaptic transmission; CC: Golgi apparatus, Golgi membrane, cell projection, cell surface, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, synapse
Pathways:
UniProt: Q9ER65
Entrez ID: 64085
|
Does Knockout of Epha1 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Epha1
|
cell proliferation
|
Regulatory T cell
|
Gene: Epha1 (Eph receptor A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell adhesion, cell surface receptor protein tyrosine kinase signaling pathway, ephrin receptor signaling pathway, negative regulation of cell migration, positive regulation of angiogenesis, positive regulation of cell migration, positive regulation of cell-matrix adhesion, positive regulation of stress fiber assembly, substrate adhesion-dependent cell spreading; MF: ATP binding, ephrin receptor activity, fibronectin binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity; CC: membrane, plasma membrane, receptor complex
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA-mediated growth cone collapse, Nervous system development
UniProt: Q60750
Entrez ID: 13835
|
Does Knockout of Grip1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Grip1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Grip1 (glutamate receptor interacting protein 1)
Type: protein-coding
Summary: This gene encodes a protein containing multiple PDZ (post synaptic density protein, Drosophila disc large tumor suppressor, and zonula occludens-1 protein) domains. The encoded protein acts as a mediator between cytoskeletal and membrane proteins, particularly in neuronal cells, and facilitates complex formation at the cell membrane. Mutation of this gene can cause embryonic lethality resulting from defects of the dermo-epidermal junction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: cellular response to brain-derived neurotrophic factor stimulus, cellular response to phorbol 13-acetate 12-myristate, dendrite arborization, intracellular protein localization, nervous system development, neurotransmitter receptor transport, endosome to postsynaptic membrane, positive regulation of dendrite morphogenesis, positive regulation of neuron projection arborization, positive regulation of protein localization to plasma membrane, regulation of synaptic scaling, vesicle-mediated transport in synapse; MF: GTPase binding, PDZ domain binding, ionotropic glutamate receptor binding, protein binding, protein-containing complex binding, signaling receptor binding; CC: GABA-ergic synapse, cell projection, cytoplasm, cytoplasmic vesicle, dendrite, dendritic shaft, dendritic spine, dendritic spine head, dendritic spine neck, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, exocyst, glutamatergic synapse, membrane, membrane raft, microtubule, neuron projection, neuronal cell body, perikaryon, perinuclear region of cytoplasm, plasma membrane, postsynapse, postsynaptic density, postsynaptic membrane, presynapse, presynaptic active zone, presynaptic membrane, proximal dendrite, recycling endosome, spine synapse, synapse, synaptic cleft, synaptic membrane, terminal bouton
Pathways: Glutamate binding, activation of AMPA receptors and synaptic plasticity, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transmission across Chemical Synapses
UniProt: Q925T6
Entrez ID: 74053
|
Does Knockout of Prph in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Prph
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prph (peripherin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoskeleton organization, intermediate filament cytoskeleton organization, intermediate filament organization; MF: protein binding, protein-containing complex binding, structural constituent of cytoskeleton, structural molecule activity; CC: C-fiber, axon, cell projection, cytoplasm, cytoskeleton, intermediate filament, neurofilament, neuronal cell body, perikaryon, photoreceptor outer segment, photoreceptor outer segment membrane, plasma membrane, terminal bouton, type III intermediate filament
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse)
UniProt: G3X981, G5E846, A0A2R8W6R6, A0A2R8VKR9
Entrez ID: 19132
|
Does Knockout of Tbca in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,541
|
Knockout
|
Tbca
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Tbca (tubulin cofactor A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: post-chaperonin tubulin folding pathway, protein folding, tubulin complex assembly; MF: beta-tubulin binding, tubulin binding; CC: cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, nucleolus
Pathways:
UniProt: P48428
Entrez ID: 21371
|
Does Knockout of Atp6v1h in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Atp6v1h
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Atp6v1h (ATPase, H+ transporting, lysosomal V1 subunit H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytosis, monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; CC: ATPase complex, clathrin-coated vesicle membrane, cytoplasmic vesicle, extrinsic component of synaptic vesicle membrane, membrane, presynapse, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q8BVE3
Entrez ID: 108664
|
Does Knockout of A430033K04Rik in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
A430033K04Rik
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: A430033K04Rik (RIKEN cDNA A430033K04 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of macromolecule metabolic process, regulation of osteoblast differentiation, regulation of primary metabolic process, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: E9Q8G5
Entrez ID: 243308
|
Does Knockout of Nup54 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Nup54
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nup54 (nucleoporin 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, mRNA transport, nuclear pore organization, nucleocytoplasmic transport, protein localization to nuclear inner membrane, protein targeting, protein transport, regulation of protein import into nucleus; MF: identical protein binding, protein-containing complex binding, structural constituent of nuclear pore; CC: membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore central transport channel, nucleus, protein-containing complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q8BTS4
Entrez ID: 269113
|
Does Knockout of Ccrl2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Ccrl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ccrl2 (C-C motif chemokine receptor-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium-mediated signaling, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, immune response, inflammatory response, positive regulation of cytosolic calcium ion concentration, signal transduction; MF: C-C chemokine binding, C-C chemokine receptor activity, CCR chemokine receptor binding, G protein-coupled receptor activity, chemokine receptor activity, chemokine receptor binding; CC: cytoplasm, external side of plasma membrane, membrane, plasma membrane
Pathways: Chemokine receptors bind chemokines, Class A/1 (Rhodopsin-like receptors), GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: O35457
Entrez ID: 54199
|
Does Knockout of Ung in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,545
|
Knockout
|
Ung
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Ung (uracil DNA glycosylase)
Type: protein-coding
Summary: Enables uracil DNA N-glycosylase activity. Acts upstream of or within isotype switching and somatic hypermutation of immunoglobulin genes. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and olfactory epithelium. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair, base-excision repair, AP site formation via deaminated base removal, isotype switching, negative regulation of apoptotic process, somatic hypermutation of immunoglobulin genes, somatic recombination of immunoglobulin gene segments; MF: damaged DNA binding, hydrolase activity, hydrolase activity, hydrolyzing N-glycosyl compounds, ribosomal small subunit binding, uracil DNA N-glycosylase activity; CC: mitochondrion, nucleoplasm, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Base-Excision Repair, AP Site Formation, Cleavage of the damaged pyrimidine , DNA Repair, Depyrimidination, Displacement of DNA glycosylase by APEX1, Primary immunodeficiency - Mus musculus (mouse), Resolution of Abasic Sites (AP sites), purine and pyrimidine metabolism, pyrimidine ribonucleosides degradation II
UniProt: P97931
Entrez ID: 22256
|
Does Knockout of Kif9 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Kif9
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kif9 (kinesin family member 9)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP hydrolysis activity; identical protein binding activity; and microtubule motor activity. Involved in regulation of flagellated sperm motility. Located in sperm flagellum. Is expressed in cochlea; hippocampus; lateral ventricle choroid plexus; metanephros; and metencephalon part of 4th ventricle choroid plexus. Orthologous to human KIF9 (kinesin family member 9). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: extracellular matrix disassembly, microtubule-based movement, organelle disassembly, regulation of flagellated sperm motility, regulation of podosome assembly; MF: ATP binding, ATP hydrolysis activity, identical protein binding, microtubule binding, microtubule motor activity, nucleotide binding, protein binding; CC: cell projection, cilium, cytoplasm, cytoskeleton, cytosol, kinesin complex, microtubule, motile cilium, podosome, sperm flagellum, vesicle
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport, phosphate acquisition II
UniProt: Q9WV04
Entrez ID: 16578
|
Does Knockout of Il21 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Il21
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Il21 (interleukin 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell apoptotic process, T follicular helper cell differentiation, cell development, cell maturation, cellular response to virus, defense response to other organism, germinal center B cell differentiation, immune response, positive regulation of B cell differentiation, positive regulation of B cell proliferation, positive regulation of T cell proliferation, positive regulation of cell population proliferation, positive regulation of cytokine production, positive regulation of immunoglobulin production, positive regulation of interleukin-10 production, positive regulation of interleukin-17 production, positive regulation of lymphocyte activation, positive regulation of natural killer cell cytokine production, positive regulation of natural killer cell differentiation, positive regulation of natural killer cell mediated cytotoxicity, positive regulation of type II interferon production, response to virus, signal transduction; MF: cytokine activity, cytokine receptor binding, interleukin-2 receptor binding; CC: extracellular region, extracellular space
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-2 family signaling, Interleukin-21 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Signaling by Interleukins, Th17 cell differentiation - Mus musculus (mouse)
UniProt: Q9ES17
Entrez ID: 60505
|
Does Knockout of Znhit3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Znhit3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Znhit3 (zinc finger, HIT type 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: box C/D snoRNP assembly, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: metal ion binding, molecular_function, zinc ion binding; CC: cytoplasm, nucleus, pre-snoRNP complex
Pathways:
UniProt: Q9CQK1
Entrez ID: 448850
|
Does Knockout of Mir6420 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Mir6420
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Mir6420 (microRNA 6420)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465228
|
Does Knockout of Gtpbp2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Gtpbp2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Gtpbp2 (GTP binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear-transcribed mRNA catabolic process, no-go decay, rescue of stalled ribosome, translational elongation; MF: GTP binding, GTPase activity, alpha-aminoacyl-tRNA binding, identical protein binding, nucleotide binding, protein binding, translation elongation factor activity
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q3UJK4
Entrez ID: 56055
|
Does Knockout of Tada2b in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Tada2b
|
cell cycle progression
|
breast epithelium
|
Gene: Tada2b (transcriptional adaptor 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, regulation of transcription by RNA polymerase II; MF: chromatin binding, transcription coactivator activity; CC: SAGA-type complex, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: D3YW26, D3Z4Z0
Entrez ID: 231151
|
Does Knockout of Nup93 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Nup93
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nup93 (nucleoporin 93)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA transport, nuclear envelope organization, nuclear pore complex assembly, nucleocytoplasmic transport, poly(A)+ mRNA export from nucleus, positive regulation of SMAD protein signal transduction, protein import into nucleus, protein transport; MF: protein binding, structural constituent of nuclear pore; CC: centrosome, membrane, nuclear envelope, nuclear membrane, nuclear periphery, nuclear pore, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q8BJ71
Entrez ID: 71805
|
Does Knockout of Chrdl1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Chrdl1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Chrdl1 (chordin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMPA glutamate receptor clustering, BMP signaling pathway, cell differentiation, cell fate determination, embryonic axis specification, excitatory chemical synaptic transmission, eye development, negative regulation of BMP signaling pathway, nervous system development, neuron differentiation, ossification, regulation of synaptic plasticity, synapse maturation, system development; MF: BMP binding, transforming growth factor beta binding; CC: extracellular region, plasma membrane, synapse
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Signal Transduction, Signaling by BMP, Signaling by TGFB family members
UniProt: Q920C1
Entrez ID: 83453
|
Does Knockout of Gins2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Gins2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gins2 (GINS complex subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, double-strand break repair via break-induced replication; CC: CMG complex, GINS complex, chromosome, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA strand elongation, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: Q9D600
Entrez ID: 272551
|
Does Knockout of Slco1c1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Slco1c1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Slco1c1 (solute carrier organic anion transporter family, member 1c1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid and bile salt transport, lipid transport, monoatomic ion transport, positive regulation of thyroid hormone generation, sodium-independent organic anion transport, thyroid hormone transport, transmembrane transport; MF: bile acid transmembrane transporter activity, organic anion transmembrane transporter activity, sodium-independent organic anion transmembrane transporter activity, thyroid hormone transmembrane transporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways: Organic anion transport by SLCO transporters, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Thyroid hormone signaling pathway - Mus musculus (mouse), Transport of small molecules
UniProt: Q9ERB5
Entrez ID: 58807
|
Does Knockout of Racgap1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Racgap1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Racgap1 (Rac GTPase-activating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, actomyosin contractile ring assembly, cell differentiation, cell division, erythrocyte differentiation, mitotic cytokinesis, mitotic spindle midzone assembly, monoatomic ion transport, neuroblast proliferation, positive regulation of cytokinesis, regulation of attachment of spindle microtubules to kinetochore, regulation of embryonic development, signal transduction, spermatogenesis, sulfate transmembrane transport; MF: GTPase activator activity, alpha-tubulin binding, beta-tubulin binding, gamma-tubulin binding, lipid binding, metal ion binding, microtubule binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein kinase binding, protein-macromolecule adaptor activity, zinc ion binding; CC: Flemming body, acrosomal vesicle, centralspindlin complex, cleavage furrow, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, membrane, midbody, mitotic spindle, nucleoplasm, nucleus, plasma membrane, spindle, spindle midzone
Pathways: Adaptive Immune System, CDC42 GTPase cycle, COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q9WVM1
Entrez ID: 26934
|
Does Knockout of Eno4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Eno4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Eno4 (enolase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium organization, flagellated sperm motility, glycolytic process; MF: lyase activity, magnesium ion binding, phosphopyruvate hydratase activity, protein binding; CC: phosphopyruvate hydratase complex, sperm principal piece
Pathways: Gluconeogenesis, Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, RNA degradation - Mus musculus (mouse), gluconeogenesis I, glycolysis I, glycolysis III, glycolysis V (Pyrococcus)
UniProt: Q8C042
Entrez ID: 226265
|
Does Knockout of Atf2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Atf2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Atf2 (activating transcription factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, DNA damage response, JNK cascade, MAPK cascade, NK T cell differentiation, abducens nucleus development, adipose tissue development, amelogenesis, apoptotic process, apoptotic process involved in development, brainstem development, brown fat cell proliferation, cellular response to anisomycin, cellular response to leucine starvation, cellular response to oxidative stress, cellular response to virus, detection of cell density, energy homeostasis, facial nucleus development, gene expression, growth plate cartilage chondrocyte differentiation, growth plate cartilage chondrocyte proliferation, heart development, hematopoietic progenitor cell differentiation, hepatocyte apoptotic process, hypoglossal nucleus development, in utero embryonic development, intrinsic apoptotic signaling pathway in response to hypoxia, lipid metabolic process, liver development, mRNA transcription by RNA polymerase II, mitotic intra-S DNA damage checkpoint signaling, motor neuron apoptotic process, negative regulation of angiogenesis, negative regulation of epithelial cell proliferation, negative regulation of transcription by RNA polymerase II, neurofilament cytoskeleton organization, outflow tract morphogenesis, p38MAPK cascade, positive regulation of DNA-binding transcription factor activity, positive regulation of cardiac muscle myoblast proliferation, positive regulation of gene expression, positive regulation of mitochondrial membrane permeability involved in apoptotic process, positive regulation of neuron apoptotic process, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta2 production, protein import into nucleus, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to osmotic stress, temperature homeostasis, transcription initiation-coupled chromatin remodeling, vacuole organization, white fat cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding, cAMP response element binding protein binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, histone H2B acetyltransferase activity, histone H4 acetyltransferase activity, identical protein binding, leucine zipper domain binding, metal ion binding, promoter-specific chromatin binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein kinase binding, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: CCAAT-binding factor complex, H4 histone acetyltransferase complex, RNA polymerase II transcription regulator complex, chromatin, cytoplasm, membrane, mitochondrial outer membrane, mitochondrion, nucleoplasm, nucleus, site of double-strand break
Pathways: Activation of the AP-1 family of transcription factors, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chromatin modifying enzymes, Chromatin organization, Cocaine addiction - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cytokine Signaling in Immune system, Dopaminergic synapse - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HATs acetylate histones, Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin secretion - Mus musculus (mouse), Interleukin-17 signaling, Longevity regulating pathway - Mus musculus (mouse), MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), MAPK targets/ Nuclear events mediated by MAP kinases, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, PI3K-Akt signaling pathway - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Signaling by Interleukins, TNF signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Thermogenesis - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Viral carcinogenesis - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P16951
Entrez ID: 11909
|
Does Knockout of Mis18a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Mis18a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mis18a (MIS18 kinetochore protein A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CENP-A containing chromatin assembly, cell division, chromosome segregation, heterochromatin formation, pericentric heterochromatin organization, protein localization to chromosome, centromeric region; MF: identical protein binding, metal ion binding, protein binding, protein-macromolecule adaptor activity; CC: CENP-A recruiting complex, chromatin, chromosome, chromosome, centromeric region, cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, Nucleosome assembly
UniProt: Q9CZJ6
Entrez ID: 66578
|
Does Knockout of Glipr1l2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Glipr1l2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Glipr1l2 (GLI pathogenesis-related 1 like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular space, membrane
Pathways:
UniProt: Q9CQ35
Entrez ID: 67537
|
Does Knockout of Dmrtc1c2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Dmrtc1c2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dmrtc1c2 (DMRT-like family C1c2)
Type: protein-coding
Summary: Is expressed in reproductive system. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q14AJ8, Q9D410, B1AX27
Entrez ID: 668357
|
Does Knockout of Lin28a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Lin28a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lin28a (lin-28 homolog A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, cellular response to glucose stimulus, germ cell development, miRNA catabolic process, miRNA metabolic process, negative regulation of glial cell differentiation, negative regulation of pre-miRNA processing, negative regulation of translation, positive regulation of TOR signaling, positive regulation of cell proliferation involved in kidney development, positive regulation of cytoplasmic translation, positive regulation of neuron differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of translation, post-transcriptional regulation of gene expression, pre-miRNA processing, regulation of miRNA-mediated gene silencing, regulatory ncRNA-mediated gene silencing, stem cell differentiation, stem cell population maintenance; MF: G-quadruplex RNA binding, RNA binding, mRNA binding, metal ion binding, miRNA binding, nucleic acid binding, pre-miRNA binding, protein binding, protein-RNA adaptor activity, sequence-specific mRNA binding, translation initiation factor binding, zinc ion binding; CC: P-body, cytoplasm, cytoplasmic stress granule, cytosol, endoplasmic reticulum, nucleolus, nucleus, rough endoplasmic reticulum
Pathways:
UniProt: Q8K3Y3
Entrez ID: 83557
|
Does Knockout of Tas2r138 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Tas2r138
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tas2r138 (taste receptor, type 2, member 138)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane, plasma membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse)
UniProt: Q7TQA6
Entrez ID: 387513
|
Does Knockout of Pced1a in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Pced1a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pced1a (PC-esterase domain containing 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6P1Z5
Entrez ID: 319513
|
Does Knockout of Hibch in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Hibch
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hibch (3-hydroxyisobutyryl-Coenzyme A hydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-valine catabolic process, branched-chain amino acid catabolic process; MF: 3-hydroxyisobutyryl-CoA hydrolase activity, hydrolase activity; CC: mitochondrion
Pathways: Branched-chain amino acid catabolism, Metabolism, Metabolism of amino acids and derivatives, Propanoate metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse), valine degradation, valine degradation I
UniProt: Q8QZS1
Entrez ID: 227095
|
Does Knockout of Ccdc62 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ccdc62
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ccdc62 (coiled-coil domain containing 62)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst hatching, cellular response to estradiol stimulus, estrogen receptor signaling pathway, positive regulation of transcription by RNA polymerase II, spermatid development; MF: nuclear estrogen receptor binding, protein binding, transcription coactivator activity; CC: acrosomal vesicle, cytoplasm, cytoplasmic vesicle, nucleus
Pathways:
UniProt: E9PVD1
Entrez ID: 208908
|
Does Knockout of Prdm14 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Prdm14
|
cell cycle progression
|
breast epithelium
|
Gene: Prdm14 (PR domain containing 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell fate specification, cell morphogenesis, embryo implantation, epigenetic regulation of gene expression, fertilization, germ cell development, germ-line stem cell population maintenance, homeostasis of number of cells within a tissue, inactivation of paternal X chromosome by genomic imprinting, inner cell mass cell fate commitment, methylation, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, positive regulation of flagellated sperm motility, positive regulation of stem cell population maintenance, regulation of gene expression, regulation of transcription by RNA polymerase II, stem cell population maintenance; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin DNA binding, histone methyltransferase binding, metal ion binding, methyltransferase activity, methyltransferase regulator activity, protein binding, transferase activity, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: E9Q3T6
Entrez ID: 383491
|
Does Knockout of Cops8 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Cops8
|
cell cycle progression
|
breast epithelium
|
Gene: Cops8 (COP9 signalosome subunit 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COP9 signalosome assembly, negative regulation of cell population proliferation, protein deneddylation; CC: COP9 signalosome, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q8VBV7
Entrez ID: 108679
|
Does Knockout of Cebpb in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Cebpb
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cebpb (CCAAT/enhancer binding protein beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, T-helper 1 cell activation, brown fat cell differentiation, cell differentiation, cellular response to amino acid stimulus, cellular response to interleukin-1, cellular response to lipopolysaccharide, defense response to bacterium, embryonic placenta development, fat cell differentiation, granuloma formation, hepatocyte proliferation, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, liver development, liver regeneration, mammary gland epithelial cell differentiation, mammary gland epithelial cell proliferation, memory, myeloid cell development, negative regulation of DNA-templated transcription, negative regulation of T cell proliferation, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, neuron differentiation, ovarian follicle development, positive regulation of DNA-templated transcription, positive regulation of biomineral tissue development, positive regulation of cold-induced thermogenesis, positive regulation of fat cell differentiation, positive regulation of gene expression, positive regulation of inflammatory response, positive regulation of interleukin-4 production, positive regulation of osteoblast differentiation, positive regulation of sodium-dependent phosphate transport, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell differentiation, regulation of dendritic cell differentiation, regulation of interleukin-6 production, regulation of odontoblast differentiation, regulation of osteoclast differentiation, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to lipopolysaccharide; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, histone acetyltransferase binding, histone deacetylase binding, identical protein binding, kinase binding, nuclear glucocorticoid receptor binding, protein binding, protein heterodimerization activity, protein homodimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, ubiquitin-like protein ligase binding; CC: C/EBP complex, CHOP-C/EBP complex, RNA polymerase II transcription regulator complex, chromatin, condensed chromosome, centromeric region, cytoplasm, nuclear matrix, nucleoplasm, nucleus
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, IL-17 signaling pathway - Mus musculus (mouse), Senescence-Associated Secretory Phenotype (SASP), TNF signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: P28033
Entrez ID: 12608
|
Does Knockout of Cct4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Cct4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cct4 (chaperonin containing TCP1 subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, scaRNA localization to Cajal body; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, cell projection, centrosome, chaperonin-containing T-complex, cilium, cytoplasm, cytoskeleton, cytosol, melanosome, microtubule, nucleoplasm, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: P80315
Entrez ID: 12464
|
Does Knockout of Pdk2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Pdk2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Pdk2 (pyruvate dehydrogenase kinase, isoenzyme 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to nutrient, cellular response to reactive oxygen species, glucose homeostasis, insulin receptor signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, regulation of calcium-mediated signaling, regulation of gluconeogenesis, regulation of glucose metabolic process, regulation of ketone metabolic process, regulation of pH, regulation of pyruvate decarboxylation to acetyl-CoA; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, pyruvate dehydrogenase (acetyl-transferring) kinase activity, transferase activity; CC: cytosol, mitochondrial matrix, mitochondrion, nucleoplasm, pyruvate dehydrogenase complex
Pathways: Aerobic respiration and respiratory electron transport, Diabetic cardiomyopathy - Mus musculus (mouse), Metabolism, Pyruvate metabolism, Regulation of pyruvate dehydrogenase (PDH) complex, Regulation of pyruvate metabolism, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid
UniProt: Q9JK42
Entrez ID: 18604
|
Does Knockout of Dct in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Dct
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dct (dopachrome tautomerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell development, developmental pigmentation, melanin biosynthetic process, melanin biosynthetic process from tyrosine, pigmentation, positive regulation of neuroblast proliferation, response to blue light, ventricular zone neuroblast division; MF: dopachrome isomerase activity, isomerase activity, metal ion binding, oxidoreductase activity; CC: cytoplasm, cytosol, melanosome, melanosome membrane, membrane, plasma membrane
Pathways: Melanin biosynthesis, Melanogenesis - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Tyrosine metabolism - Mus musculus (mouse), eumelanin biosynthesis
UniProt: P29812
Entrez ID: 13190
|
Does Knockout of Fgf3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Fgf3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Fgf3 (fibroblast growth factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, fibroblast growth factor receptor signaling pathway, negative regulation of cardiac muscle tissue development, neurogenesis, organ induction, otic vesicle formation, positive regulation of MAPK cascade, positive regulation of cell division, positive regulation of cell population proliferation, post-anal tail morphogenesis, regulation of cell migration, regulation of developmental process, regulation of multicellular organismal process, semicircular canal morphogenesis, thymus development; MF: fibroblast growth factor receptor binding, growth factor activity, protein binding; CC: Golgi apparatus, cytoplasm, endoplasmic reticulum, extracellular space, nucleus
Pathways: Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Melanoma - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse)
UniProt: D3YWD4, Q0VG15
Entrez ID: 14174
|
Does Knockout of Lypd4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Lypd4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lypd4 (Ly6/Plaur domain containing 4)
Type: protein-coding
Summary: Acts upstream of or within binding activity of sperm to zona pellucida and sperm migration through the uterotubal junction. Is active in acrosomal vesicle. Orthologous to human LYPD4 (LY6/PLAUR domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: binding of sperm to zona pellucida, biological_process, single fertilization, sperm migration through the uterotubal junction; CC: acrosomal vesicle, membrane, plasma membrane, plasma membrane raft, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q8BVP6
Entrez ID: 232973
|
Does Knockout of Vmn1r192 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Vmn1r192
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Vmn1r192 (vomeronasal 1 receptor 192)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8K4C9
Entrez ID: 252907
|
Does Knockout of Ubl3 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Ubl3
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Ubl3 (ubiquitin-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q9Z2M6
Entrez ID: 24109
|
Does Knockout of Psma6 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Psma6
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Psma6 (proteasome subunit alpha 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of canonical NF-kappaB signal transduction, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, regulation of inflammatory response, skeletal muscle tissue development, ubiquitin-dependent protein catabolic process; MF: NF-kappaB binding, RNA binding, protein binding; CC: P-body, cilium, cytoplasm, cytosol, mitochondrion, myofibril, nuclear matrix, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, ribosome, sarcomere
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9QUM9
Entrez ID: 26443
|
Does Knockout of Kmt5b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Kmt5b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kmt5b (lysine methyltransferase 5B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, methylation, muscle organ development, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of isotype switching; MF: S-adenosyl-L-methionine binding, chromatin binding, histone H4K20 methyltransferase activity, histone H4K20 monomethyltransferase activity, histone H4K20me methyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, transferase activity; CC: centrosome, chromosome, ciliary basal body, cilium, condensed chromosome, centromeric region, cytoplasmic ribonucleoprotein granule, fibrillar center, intercellular bridge, microtubule cytoskeleton, mitotic spindle, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Chromatin modifying enzymes, Chromatin organization, Lysine degradation - Mus musculus (mouse), PKMTs methylate histone lysines
UniProt: Q3U8K7
Entrez ID: 225888
|
Does Knockout of Brf1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Brf1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Brf1 (BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, positive regulation of transcription by RNA polymerase III, regulation of mRNA stability, transcription by RNA polymerase III, transcription preinitiation complex assembly; MF: RNA polymerase III general transcription initiation factor activity, RNA polymerase III type 3 promoter sequence-specific DNA binding, TBP-class protein binding, metal ion binding, zinc ion binding; CC: nucleus, transcription factor TFIIIB complex, transcription preinitiation complex
Pathways:
UniProt: G3X8S2
Entrez ID: 72308
|
Does Knockout of Polr2g in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Polr2g
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Polr2g (polymerase (RNA) II (DNA directed) polypeptide G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, DNA-templated transcription initiation, nuclear-transcribed mRNA catabolic process, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of translational initiation, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: RNA binding, nucleic acid binding, nucleotidyltransferase activity, single-stranded DNA binding, single-stranded RNA binding, transferase activity, translation initiation factor binding; CC: DNA-directed RNA polymerase complex, P-body, RNA polymerase II, core complex, nucleoplasm, nucleus
Pathways: DNA Repair, Dual incision in TC-NER, ESR-mediated signaling, Estrogen-dependent gene expression, FGFR2 alternative splicing, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism of RNA, Nucleotide Excision Repair, Processing of Capped Intron-Containing Pre-mRNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase - Mus musculus (mouse), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P62488
Entrez ID: 67710
|
Does Knockout of Tmem215 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Tmem215
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tmem215 (transmembrane protein 215)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, negative regulation of retinal cell programmed cell death, sprouting angiogenesis
Pathways:
UniProt: A7E1Z1
Entrez ID: 320500
|
Does Knockout of Fbxo43 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Fbxo43
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fbxo43 (F-box protein 43)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiotic cell cycle, meiotic nuclear division, negative regulation of cell cycle process, negative regulation of meiotic nuclear division, negative regulation of protein catabolic process, protein ubiquitination, regulation of meiotic nuclear division, regulation of mitotic nuclear division; MF: metal ion binding, protein binding, zinc ion binding; CC: female germ cell nucleus, nucleus
Pathways: Oocyte meiosis - Mus musculus (mouse)
UniProt: A0A2I3BQX6, G3X9B2
Entrez ID: 78803
|
Does Knockout of Lrfn4 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Lrfn4
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Lrfn4 (leucine rich repeat and fibronectin type III domain containing 4)
Type: protein-coding
Summary: Involved in regulation of postsynaptic density assembly; regulation of presynapse assembly; and synaptic membrane adhesion. Located in cell surface. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; liver; primary head vein; reproductive system; and sensory organ. Orthologous to human LRFN4 (leucine rich repeat and fibronectin type III domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of postsynaptic density assembly, regulation of presynapse assembly, synaptic membrane adhesion; CC: GABA-ergic synapse, cell surface, glutamatergic synapse, membrane, postsynaptic density membrane
Pathways: Neuronal System, Protein-protein interactions at synapses, Synaptic adhesion-like molecules
UniProt: Q80XU8
Entrez ID: 225875
|
Does Knockout of Prl2c5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Prl2c5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Prl2c5 (prolactin family 2, subfamily c, member 5)
Type: protein-coding
Summary: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels; MF: hormone activity, prolactin receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9JLV9
Entrez ID: 107849
|
Does Knockout of Lsm6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Lsm6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Lsm6 (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA catabolic process, mRNA processing, mRNA splicing, via spliceosome, maturation of SSU-rRNA, rRNA processing, tRNA processing; MF: RNA binding, protein heterodimerization activity; CC: Lsm2-8 complex, P-body, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, nucleolus, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex, spliceosomal complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: P62313
Entrez ID: 78651
|
Does Knockout of Hat1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Hat1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hat1 (histone aminotransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, subtelomeric heterochromatin formation; MF: acyltransferase activity, histone H4 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone acetyltransferase activity, histone binding, protein-lysine-acetyltransferase activity, transferase activity; CC: chromatin, chromosome, telomeric region, mitochondrion, nuclear matrix, nucleoplasm, nucleus, protein-containing complex
Pathways: Alcoholism - Mus musculus (mouse), Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, Neutrophil extracellular trap formation - Mus musculus (mouse)
UniProt: Q8BY71
Entrez ID: 107435
|
Does Knockout of Fbxl22 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Fbxl22
|
cell cycle progression
|
breast epithelium
|
Gene: Fbxl22 (F-box and leucine-rich repeat protein 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination; CC: SCF ubiquitin ligase complex, Z disc, cytoplasm, cytosol, nucleolus
Pathways:
UniProt: Q8C7B6
Entrez ID: 74165
|
Does Knockout of Pa2g4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Pa2g4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pa2g4 (proliferation-associated 2G4)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of apoptotic process and positive regulation of cell differentiation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of ribonucleoprotein complex. Is expressed in brain; heart; jaw; limb; and lung mesenchyme. Orthologous to human PA2G4 (proliferation-associated 2G4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of apoptotic process, positive regulation of cell differentiation, rRNA processing, regulation of translation; MF: RNA binding, nucleic acid binding, transcription corepressor activity, ubiquitin protein ligase binding; CC: cytoplasm, nucleolus, nucleus, ribonucleoprotein complex
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P50580
Entrez ID: 18813
|
Does Knockout of Gadd45g in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Gadd45g
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gadd45g (growth arrest and DNA-damage-inducible 45 gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 1 cell differentiation, apoptotic process, cell differentiation, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of apoptotic process, positive regulation of cold-induced thermogenesis, positive regulation of p38MAPK cascade, regulation of cell cycle; MF: identical protein binding, protein binding; CC: cytoplasm, nucleus
Pathways: Apoptosis - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Melanoma - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Thyroid cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: Q9R0S0
Entrez ID: 23882
|
Does Knockout of Sez6l2 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Sez6l2
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Sez6l2 (seizure related 6 homolog like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult locomotory behavior, cerebellar Purkinje cell layer development, synapse maturation; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, neuronal cell body, plasma membrane
Pathways:
UniProt: Q4V9Z5
Entrez ID: 233878
|
Does Knockout of Sf3b5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Sf3b5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sf3b5 (splicing factor 3b, subunit 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing; MF: RNA binding, splicing factor binding; CC: SAGA complex, U12-type spliceosomal complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q923D4
Entrez ID: 66125
|
Does Knockout of Hspa5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Hspa5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hspa5 (heat shock protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ER overload response, ERAD pathway, IRE1-mediated unfolded protein response, PERK-mediated unfolded protein response, cellular response to glucose starvation, cellular response to interleukin-4, cerebellar Purkinje cell layer development, cerebellum structural organization, endoplasmic reticulum unfolded protein response, maintenance of protein localization in endoplasmic reticulum, negative regulation of IRE1-mediated unfolded protein response, negative regulation of PERK-mediated unfolded protein response, negative regulation of apoptotic process, negative regulation of protein-containing complex assembly, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of cell migration, positive regulation of embryonic development, positive regulation of neuron projection development, positive regulation of protein ubiquitination, post-translational protein targeting to membrane, translocation, protein folding, protein refolding, proteolysis involved in protein catabolic process, response to endoplasmic reticulum stress, translational initiation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, enzyme binding, heat shock protein binding, hydrolase activity, misfolded protein binding, nucleotide binding, protein binding, protein domain specific binding, protein folding chaperone, protein serine/threonine kinase inhibitor activity, ribosome binding, ubiquitin protein ligase binding, unfolded protein binding; CC: COP9 signalosome, cell surface, cytoplasm, cytosol, dendritic shaft, endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, extracellular region, melanosome, membrane, midbody, mitochondrion, myelin sheath, neuronal cell body, nucleus, plasma membrane, protein-containing complex, smooth endoplasmic reticulum
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Immune System, Lipid and atherosclerosis - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein export - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of HSF1-mediated heat shock response, Thyroid hormone synthesis - Mus musculus (mouse)
UniProt: P20029
Entrez ID: 14828
|
Does Knockout of Eml6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Eml6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eml6 (echinoderm microtubule associated protein like 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: microtubule binding, molecular_function; CC: cytoplasm, cytoskeleton, microtubule
Pathways:
UniProt: Q5SQM0
Entrez ID: 237711
|
Does Knockout of Pgd in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Pgd
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pgd (phosphogluconate dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-gluconate metabolic process, NADP+ metabolic process, NADPH regeneration, pentose biosynthetic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch; MF: NADP binding, carbohydrate binding, carboxylic acid binding, oxidoreductase activity, phosphogluconate dehydrogenase (decarboxylating) activity; CC: cytoplasm, cytosol
Pathways: Glutathione metabolism - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), pentose phosphate pathway, pentose phosphate pathway (oxidative branch)
UniProt: Q9DCD0
Entrez ID: 110208
|
Does Knockout of Fzd5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Fzd5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fzd5 (frizzled class receptor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Spemann organizer formation, T cell differentiation in thymus, Wnt signaling pathway, angiogenesis, anterior/posterior axis specification, embryo, apoptotic process involved in morphogenesis, branching involved in labyrinthine layer morphogenesis, canonical Wnt signaling pathway, cell differentiation, cell surface receptor signaling pathway, cellular response to molecule of bacterial origin, chorionic trophoblast cell differentiation, embryonic axis specification, embryonic camera-type eye development, embryonic camera-type eye morphogenesis, eye development, glandular epithelial cell maturation, intestinal epithelial cell maturation, labyrinthine layer blood vessel development, negative regulation of cell population proliferation, non-canonical Wnt signaling pathway, positive regulation of T cell cytokine production, positive regulation of interleukin-1 beta production, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, post-embryonic camera-type eye development, presynapse assembly, regulation of bicellular tight junction assembly, regulation of chorionic trophoblast cell proliferation, signal transduction, syncytiotrophoblast cell differentiation involved in labyrinthine layer development, system development, vasculature development; MF: G protein-coupled receptor activity, Wnt receptor activity, Wnt-protein binding, amyloid-beta binding, lipid binding, protein binding, protein kinase binding, protein-containing complex binding, transmembrane signaling receptor activity, ubiquitin protein ligase binding; CC: Golgi apparatus, Golgi membrane, axon, bicellular tight junction, cell projection, cell surface, dendrite, early endosome, glutamatergic synapse, membrane, perikaryon, perinuclear region of cytoplasm, plasma membrane, synapse
Pathways: Alzheimer disease - Mus musculus (mouse), Asymmetric localization of PCP proteins, Basal cell carcinoma - Mus musculus (mouse), Beta-catenin independent WNT signaling, Breast cancer - Mus musculus (mouse), Ca2+ pathway, Cushing syndrome - Mus musculus (mouse), Disassembly of the destruction complex and recruitment of AXIN to the membrane, Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), PCP/CE pathway, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of FZD by ubiquitination, Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TCF dependent signaling in response to WNT, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9EQD0
Entrez ID: 14367
|
Does Knockout of Acad11 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Acad11
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Acad11 (acyl-Coenzyme A dehydrogenase family, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carboxylic acid catabolic process, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty acid metabolic process, lipid metabolic process; MF: acyl-CoA dehydrogenase activity, flavin adenine dinucleotide binding, long-chain fatty acyl-CoA dehydrogenase activity, medium-chain fatty acyl-CoA dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, very-long-chain fatty acyl-CoA dehydrogenase activity; CC: cytoplasm, membrane, mitochondrial membrane, mitochondrion, nucleus, peroxisome
Pathways: Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, fatty acid β-oxidation I
UniProt: Q80XL6
Entrez ID: 102632
|
Does Knockout of Ptpn20 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Ptpn20
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ptpn20 (protein tyrosine phosphatase, non-receptor type 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: catalytic activity, hydrolase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity; CC: centriolar satellite, centrosome, cytoplasm, cytoskeleton, microtubule, nucleus
Pathways:
UniProt: O55082
Entrez ID: 19256
|
Does Knockout of Tnrc6a in Pancreatic Cell Line causally result in cell proliferation?
| 1
| 2,192
|
Knockout
|
Tnrc6a
|
cell proliferation
|
Pancreatic Cell Line
|
Gene: Tnrc6a (trinucleotide repeat containing 6a)
Type: protein-coding
Summary: This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein is highly similar to a human protein that functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The human protein associates with messenger RNAs and argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies, and inhibiting its expression delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: P-body assembly, cellular response to starvation, endoderm development, maintenance of protein location in cell, miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated post-transcriptional gene silencing, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, regulation of translation, regulatory ncRNA-mediated gene silencing; MF: RNA binding, molecular adaptor activity, nucleic acid binding; CC: Golgi apparatus, P-body, RISC complex, cytoplasm, cytosol, nucleoplasm, perinuclear region of cytoplasm
Pathways: Gene Silencing by RNA, Gene expression (Transcription), Post-transcriptional silencing by small RNAs, Transcriptional regulation by small RNAs
UniProt: Q3UHK8
Entrez ID: 233833
|
Does Knockout of Birc3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Birc3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Birc3 (baculoviral IAP repeat-containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to tumor necrosis factor, necroptotic process, negative regulation of apoptotic process, negative regulation of necroptotic process, negative regulation of phosphorylation, negative regulation of reactive oxygen species metabolic process, positive regulation of protein polyubiquitination, positive regulation of protein ubiquitination, regulation of apoptotic process, regulation of cell cycle, regulation of necroptotic process, regulation of non-canonical NF-kappaB signal transduction, regulation of reactive oxygen species metabolic process; MF: cysteine-type endopeptidase inhibitor activity involved in apoptotic process, metal ion binding, protein binding, protein-containing complex binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, protein-containing complex
Pathways: Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), Cytokine Signaling in Immune system, Death Receptor Signaling, Deubiquitination, Focal adhesion - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), IKK complex recruitment mediated by RIP1, Immune System, Innate Immune System, Metabolism of proteins, MyD88-independent TLR4 cascade , NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), NOD1/2 Signaling Pathway, Necroptosis - Mus musculus (mouse), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Programmed Cell Death, RIPK1-mediated regulated necrosis, Regulated Necrosis, Regulation of TNFR1 signaling, Regulation of necroptotic cell death, Salmonella infection - Mus musculus (mouse), Signal Transduction, Small cell lung cancer - Mus musculus (mouse), TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNF signaling, TNF signaling pathway - Mus musculus (mouse), TNFR1-induced NF-kappa-B signaling pathway, TNFR1-induced proapoptotic signaling, TNFR2 non-canonical NF-kB pathway, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Toxoplasmosis - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), Ub-specific processing proteases, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: O08863
Entrez ID: 11796
|
Does Knockout of Phpt1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Phpt1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Phpt1 (phosphohistidine phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, lamellipodium organization, negative regulation of T cell receptor signaling pathway, positive regulation of cell motility; MF: actin filament binding, calcium channel inhibitor activity, enzyme inhibitor activity, hydrolase activity, phosphoprotein phosphatase activity, protein histidine phosphatase activity, transmembrane transporter binding; CC: cytoplasm, cytosol, leading edge of lamellipodium, nuclear body, nucleoplasm, plasma membrane
Pathways:
UniProt: Q9DAK9
Entrez ID: 75454
|
Does Knockout of Cd209g in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Cd209g
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Cd209g (CD209g antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, pattern recognition receptor activity
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: D3Z5D4
Entrez ID: 70192
|
Does Knockout of Col23a1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Col23a1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Col23a1 (collagen, type XXIII, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: extracellular matrix structural constituent conferring tensile strength, heparin binding, identical protein binding; CC: cell surface, collagen trimer, extracellular matrix, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen formation, Extracellular matrix organization, Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q8K4G2
Entrez ID: 237759
|
Does Knockout of Rpl30 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Rpl30
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Rpl30 (ribosomal protein L30)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cytoplasmic translation, defense response to Gram-negative bacterium, killing of cells of another organism; MF: RNA binding, selenocysteine insertion sequence binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleus, postsynapse, postsynaptic density, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62889
Entrez ID: 19946
|
Does Knockout of Vps33a in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Vps33a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Vps33a (VPS33A CORVET/HOPS core subunit)
Type: protein-coding
Summary: Acts upstream of or within pigmentation; platelet formation; and regulation of developmental pigmentation. Located in autophagosome and lysosome. Part of CORVET complex. Is expressed in ganglia. Used to study Hermansky-Pudlak syndrome. Orthologous to human VPS33A (VPS33A core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: autophagosome maturation, autophagy, endosome to lysosome transport, intracellular protein transport, lysosome localization, melanosome localization, pigmentation, platelet formation, protein transport, regulation of developmental pigmentation, regulation of lysosomal lumen pH, vesicle-mediated transport; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, autophagosome, clathrin complex, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q9D2N9
Entrez ID: 77573
|
Does Knockout of Atf4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Atf4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Atf4 (activating transcription factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GDF15-GFRAL signaling pathway, HRI-mediated signaling, L-asparagine metabolic process, PERK-mediated unfolded protein response, bone mineralization, cellular response to amino acid starvation, cellular response to glucose starvation, cellular response to hypoxia, cellular response to leucine starvation, cellular response to oxidative stress, circadian regulation of gene expression, circadian rhythm, embryonic hemopoiesis, endoplasmic reticulum unfolded protein response, gamma-aminobutyric acid signaling pathway, gene expression, gluconeogenesis, integrated stress response signaling, intracellular calcium ion homeostasis, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, lens fiber cell morphogenesis, mRNA transcription by RNA polymerase II, mitochondrial respirasome assembly, negative regulation of cold-induced thermogenesis, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of potassium ion transport, negative regulation of transcription by RNA polymerase II, neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of biomineral tissue development, positive regulation of gene expression, positive regulation of neuron apoptotic process, positive regulation of sodium-dependent phosphate transport, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular endothelial growth factor production, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of osteoblast differentiation, regulation of synaptic plasticity, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to manganese-induced endoplasmic reticulum stress, response to nutrient levels, response to toxic substance, rhythmic process; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding, cAMP response element binding protein binding, general transcription initiation factor binding, identical protein binding, leucine zipper domain binding, promoter-specific chromatin binding, protein binding, protein heterodimerization activity, protein kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: ATF1-ATF4 transcription factor complex, ATF4-CREB1 transcription factor complex, CHOP-ATF4 complex, Lewy body core, RNA polymerase II transcription regulator complex, centrosome, cytoplasm, cytoskeleton, dendrite membrane, membrane, mitochondrion, neuron projection, nuclear periphery, nuclear speck, nucleoplasm, nucleus, plasma membrane, protein-containing complex, transcription regulator complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q06507
Entrez ID: 11911
|
Does Knockout of Krr1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Krr1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Krr1 (KRR1, small subunit (SSU) processome component, homolog (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, nucleic acid binding; CC: chromosome, intercellular bridge, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8BGA5
Entrez ID: 52705
|
Does Knockout of Npy4r in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Npy4r
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Npy4r (neuropeptide Y receptor Y4)
Type: protein-coding
Summary: Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in neuron projection and plasma membrane. Orthologous to several human genes including NPY4R (neuropeptide Y receptor Y4). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled receptor activity, neuropeptide Y receptor activity, neuropeptide binding, pancreatic polypeptide receptor activity, peptide YY receptor activity, peptide binding; CC: membrane, neuron projection, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q61041
Entrez ID: 19065
|
Does Knockout of Rbm10 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Rbm10
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Rbm10 (RNA binding motif protein 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, mRNA splicing, via spliceosome, mRNA stabilization, negative regulation of cell growth involved in cardiac muscle cell development, negative regulation of cell population proliferation, negative regulation of mRNA splicing, via spliceosome, negative regulation of ribosomal large subunit export from nucleus, negative regulation of transcription by RNA polymerase II, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of execution phase of apoptosis, positive regulation of vascular associated smooth muscle cell apoptotic process, regulation of vascular associated smooth muscle cell apoptotic process; MF: RNA binding, identical protein binding, metal ion binding, miRNA binding, nucleic acid binding, single-stranded RNA binding, zinc ion binding; CC: nuclear speck, nucleolus, nucleus, protein-containing complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q99KG3
Entrez ID: 236732
|
Does Knockout of Socs3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Socs3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Socs3 (suppressor of cytokine signaling 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: branching involved in labyrinthine layer morphogenesis, cell surface receptor signaling pathway via JAK-STAT, cellular response to interleukin-17, cellular response to leukemia inhibitory factor, cytokine-mediated signaling pathway, interleukin-6-mediated signaling pathway, intracellular signal transduction, negative regulation of inflammatory response, negative regulation of insulin receptor signaling pathway, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of signal transduction, placenta blood vessel development, positive regulation of cell differentiation, protein ubiquitination; MF: cytokine receptor binding, miRNA binding, phosphotyrosine residue binding, protein binding, protein tyrosine kinase inhibitor activity; CC: cytoplasmic side of plasma membrane, cytosol
Pathways: Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of CSF3 (G-CSF) signaling, Influenza A - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, Interferon gamma signaling, Interleukin-6 family signaling, Interleukin-6 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Metabolism of proteins, Neddylation, Non-alcoholic fatty liver disease - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PTK6 Activates STAT3, Post-translational protein modification, Prolactin signaling pathway - Mus musculus (mouse), Regulation of IFNG signaling, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by Interleukins, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, TNF signaling pathway - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: O35718
Entrez ID: 12702
|
Does Knockout of Cyp2d26 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Cyp2d26
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cyp2d26 (cytochrome P450, family 2, subfamily d, polypeptide 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, response to xenobiotic stimulus, xenobiotic metabolic process; MF: anandamide 11,12 epoxidase activity, anandamide 14,15 epoxidase activity, anandamide 8,9 epoxidase activity, aromatase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, mitochondrion
Pathways: Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q8CIM7
Entrez ID: 76279
|
Does Knockout of Tmed9 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Tmed9
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tmed9 (transmembrane p24 trafficking protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPI coating of Golgi vesicle, Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, positive regulation of organelle organization, protein transport; MF: syntaxin binding; CC: COPII-coated ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, synaptic vesicle
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q99KF1
Entrez ID: 67511
|
Does Knockout of Rpp14 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Rpp14
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rpp14 (ribonuclease P 14 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA 5'-leader removal, tRNA processing; MF: ribonuclease P RNA binding, ribonuclease P activity; CC: endoribonuclease complex, multimeric ribonuclease P complex, nucleolus, nucleus, ribonuclease P complex, ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CQH8
Entrez ID: 67053
|
Does Knockout of Fam131c in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Fam131c
|
cell cycle progression
|
breast epithelium
|
Gene: Fam131c (family with sequence similarity 131, member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2ADB2
Entrez ID: 277743
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.