prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Stxbp2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Stxbp2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Stxbp2 (syntaxin binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to type II interferon, exocytosis, intracellular protein transport, leukocyte mediated cytotoxicity, neutrophil degranulation, positive regulation of mast cell degranulation, presynaptic dense core vesicle exocytosis, protein transport, regulation of mast cell degranulation, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: protein binding, syntaxin binding, syntaxin-1 binding, syntaxin-3 binding; CC: apical plasma membrane, azurophil granule, cytolytic granule, cytosol, lamellipodium, phagocytic vesicle, plasma membrane, presynapse, protein-containing complex, secretory granule, specific granule, tertiary granule, zymogen granule membrane
Pathways: Cytokine Signaling in Immune system, Hemostasis, Immune System, Other interleukin signaling, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, Signaling by Interleukins
UniProt: Q64324
Entrez ID: 20911
|
Does Knockout of Barx1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Barx1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Barx1 (BarH-like homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, anterior/posterior pattern specification, cell-cell signaling, digestive system development, endothelial cell differentiation, negative regulation of Wnt signaling pathway, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spleen development, tissue development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q9ER42
Entrez ID: 12022
|
Does Knockout of Pcdhb11 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Pcdhb11
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pcdhb11 (protocadherin beta 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q8C5K2, Q91UZ8
Entrez ID: 93882
|
Does Knockout of Plekhm2 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Plekhm2
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Plekhm2 (pleckstrin homology domain containing, family M (with RUN domain) member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, autophagosome-lysosome fusion, late endosome to lysosome transport, lysosome localization, natural killer cell mediated cytotoxicity, regulation of protein localization; MF: kinesin binding; CC: autolysosome, cytoplasm, endosome membrane, lysosomal membrane, lysosome, membrane
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q80TQ5
Entrez ID: 69582
|
Does Knockout of Skor1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Skor1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Skor1 (SKI family transcriptional corepressor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of BMP signaling pathway, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SMAD binding, protein binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, dendrite, neuronal cell body, nucleus, transcription regulator complex
Pathways:
UniProt: Q8BX46
Entrez ID: 207667
|
Does Knockout of Gng10 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Gng10
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gng10 (guanine nucleotide binding protein (G protein), gamma 10)
Type: protein-coding
Summary: Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Is expressed in several structures, including genitourinary system; integumental system; respiratory system; tail; and vertebral axis musculature. Orthologous to human GNG10 (G protein subunit gamma 10). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G-protein beta-subunit binding; CC: heterotrimeric G-protein complex, membrane, plasma membrane
Pathways: ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of G protein gated Potassium channels, Activation of GABAB receptors, Activation of kainate receptors upon glutamate binding, Adrenaline,noradrenaline inhibits insulin secretion, Alcoholism - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Aquaporin-mediated transport, Beta-catenin independent WNT signaling, Ca2+ pathway, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chaperonin-mediated protein folding, Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Class B/2 (Secretin family receptors), Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Dopaminergic synapse - Mus musculus (mouse), ESR-mediated signaling, Extra-nuclear estrogen signaling, G alpha (12/13) signalling events, G alpha (i) signalling events, G alpha (q) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G beta:gamma signalling through BTK, G beta:gamma signalling through CDC42, G beta:gamma signalling through PI3Kgamma, G beta:gamma signalling through PLC beta, G protein gated Potassium channels, G-protein activation, G-protein beta:gamma signalling, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Mus musculus (mouse), GPCR downstream signalling, GPCR ligand binding, GPER1 signaling, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Glutamatergic synapse - Mus musculus (mouse), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Integration of energy metabolism, Inwardly rectifying K+ channels, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Metabolism, Metabolism of proteins, Morphine addiction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet homeostasis, Potassium Channels, Presynaptic function of Kainate receptors, Prostacyclin signalling through prostacyclin receptor, Protein folding, Ras signaling pathway - Mus musculus (mouse), Regulation of insulin secretion, Relaxin signaling pathway - Mus musculus (mouse), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by WNT, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, Transmission across Chemical Synapses, Transport of small molecules, Vasopressin regulates renal water homeostasis via Aquaporins
UniProt: Q9CXP8
Entrez ID: 14700
|
Does Knockout of Sh2d4b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Sh2d4b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sh2d4b (SH2 domain containing 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A6X942
Entrez ID: 328381
|
Does Knockout of Ddx51 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ddx51
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ddx51 (DEAD box helicase 51)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleus
Pathways:
UniProt: Q6P9R1
Entrez ID: 69663
|
Does Knockout of Taf1a in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Taf1a
|
cell cycle progression
|
breast epithelium
|
Gene: Taf1a (TATA-box binding protein associated factor, RNA polymerase I, A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transcription by RNA polymerase I; MF: DNA binding, protein binding; CC: RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, microtubule cytoskeleton, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination
UniProt: P97357
Entrez ID: 21339
|
Does Knockout of Osgep in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Osgep
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Osgep (O-sialoglycoprotein endopeptidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA modification, tRNA processing, tRNA threonylcarbamoyladenosine modification; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, metal ion binding, tRNA N(6)-L-threonylcarbamoyladenine synthase activity, transferase activity; CC: EKC/KEOPS complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8BWU5
Entrez ID: 66246
|
Does Knockout of Dhfr in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Dhfr
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dhfr (dihydrofolate reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon regeneration, dTMP biosynthetic process, dihydrofolate metabolic process, folic acid metabolic process, one-carbon metabolic process, regulation of removal of superoxide radicals, response to methotrexate, tetrahydrobiopterin biosynthetic process, tetrahydrofolate biosynthetic process, tetrahydrofolate interconversion, tetrahydrofolate metabolic process; MF: NADP binding, NADPH binding, RNA binding, dihydrofolate reductase activity, dihydrofolic acid binding, folate reductase activity, folic acid binding, mRNA binding, mRNA regulatory element binding translation repressor activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor, sequence-specific mRNA binding; CC: cytoplasm, cytosol, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, nucleus
Pathways: Folate biosynthesis - Mus musculus (mouse), Metabolism, Metabolism of folate and pterines, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, One carbon pool by folate - Mus musculus (mouse), folate transformations II (plants)
UniProt: P00375
Entrez ID: 13361
|
Does Knockout of Atp1a2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Atp1a2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Atp1a2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, L-ascorbic acid metabolic process, adult locomotory behavior, amygdala development, behavioral fear response, blood circulation, cell communication, cellular response to mechanical stimulus, cellular response to steroid hormone stimulus, establishment or maintenance of transmembrane electrochemical gradient, fear response, intracellular potassium ion homeostasis, intracellular sodium ion homeostasis, locomotion, locomotory exploration behavior, membrane depolarization, monoatomic cation transmembrane transport, monoatomic ion transport, negative regulation of calcium ion transmembrane transport, negative regulation of cytosolic calcium ion concentration, negative regulation of heart contraction, negative regulation of striated muscle contraction, neuronal action potential propagation, neurotransmitter uptake, olfactory cortex development, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, proton transmembrane transport, regulation of blood pressure, regulation of cardiac muscle cell contraction, regulation of heart contraction, regulation of muscle contraction, regulation of respiratory gaseous exchange by nervous system process, regulation of smooth muscle contraction, regulation of striated muscle contraction, regulation of the force of heart contraction, regulation of vasoconstriction, response to auditory stimulus, response to glycoside, response to mechanical stimulus, response to nicotine, response to potassium ion, sodium ion export across plasma membrane, sodium ion transmembrane transport, sodium ion transport, visual learning; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled monoatomic cation transmembrane transporter activity, P-type potassium transmembrane transporter activity, P-type sodium:potassium-exchanging transporter activity, metal ion binding, nucleotide binding, potassium ion binding, protein binding, protein heterodimerization activity, protein-folding chaperone binding, sodium ion binding, steroid binding, steroid hormone binding; CC: T-tubule, caveola, cell projection, cell surface, cytoplasm, dendritic spine, endoplasmic reticulum, endosome, intercalated disc, membrane, myelin sheath, neuronal cell body, organelle membrane, plasma membrane, protein-containing complex, sarcolemma, sodium:potassium-exchanging ATPase complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Bile secretion - Mus musculus (mouse), Carbohydrate digestion and absorption - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Mineral absorption - Mus musculus (mouse), Muscle contraction, Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse), Proximal tubule bicarbonate reclamation - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Transport of small molecules, cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q6PIE5
Entrez ID: 98660
|
Does Knockout of Rims3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Rims3
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Rims3 (regulating synaptic membrane exocytosis 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-ion regulated exocytosis, exocytosis, maintenance of presynaptic active zone structure, neurotransmitter transport, regulation of membrane potential, regulation of synapse organization, regulation of synaptic vesicle exocytosis, synaptic vesicle docking, synaptic vesicle priming; MF: small GTPase binding, structural constituent of presynaptic active zone, transmembrane transporter binding; CC: glutamatergic synapse, membrane, postsynaptic cytosol, presynaptic active zone cytoplasmic component, presynaptic membrane, synapse
Pathways:
UniProt: Q80U57
Entrez ID: 242662
|
Does Knockout of B3galt6 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
B3galt6
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: B3galt6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chondroitin sulfate proteoglycan biosynthetic process, dermatan sulfate proteoglycan biosynthetic process, glycosaminoglycan biosynthetic process, heparan sulfate proteoglycan biosynthetic process, protein O-linked glycosylation, protein glycosylation, proteoglycan biosynthetic process; MF: UDP-galactosyltransferase activity, galactosylxylosylprotein 3-beta-galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, Golgi medial cisterna, Golgi membrane, membrane
Pathways: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Mus musculus (mouse), Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Mus musculus (mouse), Glycosaminoglycan metabolism, Glycosaminoglycan-protein linkage region biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, chondroitin sulfate biosynthesis, dermatan sulfate biosynthesis, glycoaminoglycan-protein linkage region biosynthesis, heparan sulfate biosynthesis
UniProt: Q91Z92
Entrez ID: 117592
|
Does Knockout of Pcyt2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Pcyt2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pcyt2 (phosphate cytidylyltransferase 2, ethanolamine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process; MF: catalytic activity, ethanolamine-phosphate cytidylyltransferase activity, nucleotidyltransferase activity, transferase activity
Pathways: Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Phosphonate and phosphinate metabolism - Mus musculus (mouse), Synthesis of PE, phosphatidylethanolamine biosynthesis II
UniProt: Q922E4
Entrez ID: 68671
|
Does Knockout of Mvb12a in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Mvb12a
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mvb12a (multivesicular body subunit 12A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome to lysosome transport via multivesicular body sorting pathway, protein transport, receptor catabolic process, regulation of epidermal growth factor receptor signaling pathway, viral budding, virus maturation; MF: SH3 domain binding, lipid binding, ubiquitin binding; CC: ESCRT I complex, centrosome, cytoplasm, cytoskeleton, cytosol, endosome, late endosome membrane, membrane, nucleus, vesicle
Pathways: Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), Membrane Trafficking, Vesicle-mediated transport
UniProt: Q78HU3
Entrez ID: 73711
|
Does Knockout of Rpl28 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Rpl28
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rpl28 (ribosomal protein L28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cell body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, dendrite, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P41105
Entrez ID: 19943
|
Does Knockout of Gm4744 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Gm4744
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gm4744 (trypsinogen pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 194360
|
Does Knockout of H2-DMa in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
H2-DMa
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: H2-DMa (histocompatibility 2, class II, locus DMa)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response, immune system process, immunoglobulin mediated immune response, inner ear development, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of T cell differentiation, positive regulation of germinal center formation, positive regulation of humoral immune response, positive regulation of immune response, positive regulation of immune system process, positive thymic T cell selection, protein folding, protein transport, protein-containing complex assembly; MF: MHC class II protein complex binding, peptide antigen binding, protein binding; CC: MHC class II protein complex, cell surface, endosome, endosome membrane, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, multivesicular body
Pathways: Allograft rejection - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Asthma - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Intestinal immune network for IgA production - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: A0A494BAR2, Q31621
Entrez ID: 14998
|
Does Knockout of Lamc1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Lamc1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Lamc1 (laminin, gamma 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, axon guidance, cell adhesion, cell migration, chromatin organization, extracellular matrix disassembly, gene expression, hair cell differentiation, hair follicle cell proliferation, hair follicle morphogenesis, hemidesmosome assembly, neuron projection development, positive regulation of cell adhesion, positive regulation of integrin-mediated signaling pathway, positive regulation of muscle cell differentiation, protein-containing complex assembly, regulation of basement membrane organization, substrate adhesion-dependent cell spreading, tissue development, tissue morphogenesis; MF: extracellular matrix structural constituent, glycosphingolipid binding, protein binding; CC: basement membrane, extracellular matrix, extracellular region, laminin-1 complex, laminin-10 complex, neuromuscular junction, protein complex involved in cell-matrix adhesion, synaptic cleft
Pathways: Amoebiasis - Mus musculus (mouse), ECM-receptor interaction - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse)
UniProt: F6SFQ3, F8VQJ3, F6TLW1
Entrez ID: 226519
|
Does Knockout of Yipf1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Yipf1
|
phagocytosis
|
macrophage
|
Gene: Yipf1 (Yip1 domain family, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, Golgi medial cisterna, Golgi trans cisterna, endomembrane system, endosome, late endosome membrane, membrane, nucleoplasm, plasma membrane, trans-Golgi network, transport vesicle
Pathways:
UniProt: Q91VU1
Entrez ID: 230584
|
Does Knockout of H3f3b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
H3f3b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: H3f3b (H3.3 histone B)
Type: protein-coding
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Nov 2015].
Gene Ontology:
Pathways: Adaptive Immune System, Adherens junctions interactions, Alcoholism - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chromosome Maintenance, Co-inhibition by PD-1, Condensation of Prophase Chromosomes, ESR-mediated signaling, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Estrogen-dependent gene expression, Factors involved in megakaryocyte development and platelet production, Gene expression (Transcription), Generic Transcription Pathway, Hemostasis, Immune System, Inhibition of DNA recombination at telomere, M Phase, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Mitotic Prophase, Negative Regulation of CDH1 Gene Transcription, Neutrophil extracellular trap formation - Mus musculus (mouse), PRC2 methylates histones and DNA, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins, Signal Transduction, Signaling by Nuclear Receptors, Systemic lupus erythematosus - Mus musculus (mouse), Telomere Maintenance, Transcriptional misregulation in cancer - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: P84244
Entrez ID: 15081
|
Does Knockout of Wiz in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Wiz
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Wiz (widely-interspaced zinc finger motifs)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of nuclear cell cycle DNA replication, protein stabilization, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SET domain binding, histone methyltransferase binding, metal ion binding, protein binding, protein-containing complex binding, transcription corepressor binding, zinc ion binding; CC: midbody, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: O88286
Entrez ID: 22404
|
Does Knockout of Eif3d in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Eif3d
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Eif3d (eukaryotic translation initiation factor 3, subunit D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRES-dependent viral translational initiation, cap-dependent translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation, viral translational termination-reinitiation; MF: RNA binding, mRNA cap binding, translation initiation factor activity; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: O70194
Entrez ID: 55944
|
Does Knockout of Phf12 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Phf12
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Phf12 (PHD finger protein 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II; MF: metal ion binding, phosphatidylinositol binding, protein binding, transcription corepressor activity, transcription corepressor binding, zinc ion binding; CC: Sin3-type complex, nucleoplasm, nucleus, transcription repressor complex
Pathways:
UniProt: Q5SPL2
Entrez ID: 268448
|
Does Knockout of Eif5a in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Eif5a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Eif5a (eukaryotic translation initiation factor 5A)
Type: protein-coding
Summary: This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: cellular response to virus, negative regulation of apoptotic process, positive regulation of apoptotic process, positive regulation of cardiac muscle cell apoptotic process, positive regulation of cytosolic calcium ion concentration, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of muscle cell differentiation, positive regulation of reactive oxygen species metabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of translational elongation, positive regulation of translational termination, translation, translational elongation, tumor necrosis factor-mediated signaling pathway; MF: RNA binding, U6 snRNA binding, ribosome binding, translation elongation factor activity; CC: annulate lamellae, cytoplasm, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, neuronal cell body, nuclear pore, nucleus, synapse
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification
UniProt: P63242
Entrez ID: 276770
|
Does Knockout of Tubb5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Tubb5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tubb5 (tubulin, beta 5 class I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle, odontoblast differentiation, regulation of synapse organization, spindle assembly; MF: GTP binding, GTPase activating protein binding, GTPase activity, MHC class I protein binding, metal ion binding, nucleotide binding, protein domain specific binding, protein-containing complex binding, structural constituent of cytoskeleton, ubiquitin protein ligase binding; CC: cell body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoskeleton, cytosol, intercellular bridge, membrane raft, microtubule, microtubule cytoskeleton, mitotic spindle, nuclear envelope lumen, nucleus, protein-containing complex, tubulin complex
Pathways: AURKA Activation by TPX2, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Gap junction - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Neutrophil degranulation, Organelle biogenesis and maintenance, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Salmonella infection - Mus musculus (mouse)
UniProt: P99024
Entrez ID: 22154
|
Does Knockout of Mup14 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Mup14
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mup14 (major urinary protein 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, odorant binding, pheromone binding, small molecule binding; CC: extracellular region, extracellular space
Pathways:
UniProt: B8JI96, A2CEK7
Entrez ID: 100039116
|
Does Knockout of P4ha1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
P4ha1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: P4ha1 (procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen fibril organization; MF: L-ascorbic acid binding, dioxygenase activity, identical protein binding, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, procollagen-proline 4-dioxygenase activity; CC: endoplasmic reticulum, endoplasmic reticulum lumen, mitochondrion, procollagen-proline 4-dioxygenase complex
Pathways: Arginine and proline metabolism - Mus musculus (mouse), Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization
UniProt: Q60715
Entrez ID: 18451
|
Does Knockout of Jagn1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Jagn1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Jagn1 (jagunal homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to fungus, endoplasmic reticulum organization, granulocyte colony-stimulating factor signaling pathway, immune system process, insulin metabolic process, insulin secretion, negative regulation of insulin secretion involved in cellular response to glucose stimulus, neutrophil differentiation, neutrophil mediated immunity, neutrophil migration, protein transport, response to endoplasmic reticulum stress, response to glucose, vesicle-mediated transport; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q5XKN4
Entrez ID: 67767
|
Does Knockout of Chmp6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Chmp6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Chmp6 (charged multivesicular body protein 6)
Type: protein-coding
Summary: Predicted to be involved in several processes, including midbody abscission; regulation of protein metabolic process; and vacuolar transport. Predicted to be located in several cellular components, including bounding membrane of organelle; kinetochore microtubule; and midbody. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in multivesicular body. Is expressed in several structures, including branchial arch; facial prominence; heart; limb bud; and neural fold. Orthologous to human CHMP6 (charged multivesicular body protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: autophagosome maturation, autophagy, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, membrane fission, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein transport, regulation of mitotic spindle assembly, regulation of protein catabolic process, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; MF: protein-containing complex binding; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, endomembrane system, endosome, endosome membrane, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, midbody, multivesicular body, multivesicular body membrane, nuclear pore, plasma membrane
Pathways: Autophagy, Cell Cycle, Cell Cycle, Mitotic, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Mus musculus (mouse), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, Sealing of the nuclear envelope (NE) by ESCRT-III, Vesicle-mediated transport
UniProt: P0C0A3
Entrez ID: 208092
|
Does Knockout of Cltc in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Cltc
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cltc (clathrin heavy chain)
Type: protein-coding
Summary: Enables protein kinase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; endocytosis; and negative regulation of hyaluronan biosynthetic process. Predicted to act upstream of or within mitotic spindle assembly. Located in clathrin-coated pit. Part of membrane coat. Is active in several cellular components, including photoreceptor ribbon synapse; postsynaptic endocytic zone; and presynaptic endocytic zone membrane. Is expressed in several structures, including brain; early embryo; placenta; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi organization, amyloid-beta clearance by transcytosis, autophagy, cell division, clathrin coat assembly, clathrin coat disassembly, clathrin-dependent endocytosis, intracellular protein transport, mitotic cell cycle, mitotic spindle assembly, negative regulation of hyaluronan biosynthetic process, negative regulation of protein localization to plasma membrane, receptor internalization, receptor-mediated endocytosis, regulation of mitotic spindle organization, retrograde transport, endosome to Golgi, synaptic vesicle endocytosis, transferrin transport, vesicle-mediated transport; MF: ankyrin binding, clathrin light chain binding, disordered domain specific binding, double-stranded RNA binding, heat shock protein binding, low-density lipoprotein particle receptor binding, peptide binding, protein binding, protein kinase binding, protein serine/threonine kinase binding, structural molecule activity, ubiquitin-specific protease binding; CC: Myb complex, T-tubule, centriolar satellite, clathrin coat, clathrin coat of coated pit, clathrin coat of trans-Golgi network vesicle, clathrin complex, clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, cytosol, endomembrane system, endosome, extrinsic component of synaptic vesicle membrane, glutamatergic synapse, lysosome, melanosome, membrane, membrane coat, mitochondrion, mitotic spindle, mitotic spindle microtubule, myelin sheath, photoreceptor ribbon synapse, postsynaptic endocytic zone, presynaptic endocytic zone membrane, protein-containing complex, sarcolemma, spindle
Pathways: Adaptive Immune System, Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Beta-catenin independent WNT signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Golgi Associated Vesicle Biogenesis, Huntington disease - Mus musculus (mouse), Immune System, L1CAM interactions, LDL clearance, Lysosome - Mus musculus (mouse), Lysosome Vesicle Biogenesis, MHC class II antigen presentation, Membrane Trafficking, Nervous system development, PCP/CE pathway, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, RHO GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, Recycling pathway of L1, Retrograde neurotrophin signalling, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Synaptic vesicle cycle - Mus musculus (mouse), Transport of small molecules, VLDLR internalisation and degradation, Vesicle-mediated transport, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, WNT5A-dependent internalization of FZD4, trans-Golgi Network Vesicle Budding
UniProt: Q68FD5
Entrez ID: 67300
|
Does Knockout of Chst1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Chst1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Chst1 (carbohydrate sulfotransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-acetylglucosamine metabolic process, carbohydrate metabolic process, galactose metabolic process, inflammatory response, keratan sulfate proteoglycan biosynthetic process, keratan sulfate proteoglycan metabolic process, sulfur compound metabolic process; MF: N-acetylglucosamine 6-O-sulfotransferase activity, keratan sulfotransferase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosaminoglycan biosynthesis - keratan sulfate - Mus musculus (mouse), Glycosaminoglycan metabolism, Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q9EQC0
Entrez ID: 76969
|
Does Knockout of Timm17b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Timm17b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Timm17b (translocase of inner mitochondrial membrane 17b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein import into mitochondrial matrix, protein transport; MF: protein transmembrane transporter activity; CC: TIM23 mitochondrial import inner membrane translocase complex, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9Z0V7
Entrez ID: 21855
|
Does Knockout of Tmem175 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Tmem175
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tmem175 (transmembrane protein 175)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lysosomal lumen pH elevation, monoatomic ion transmembrane transport, monoatomic ion transport, neuron cellular homeostasis, phagosome-lysosome fusion, potassium ion transmembrane transport, potassium ion transport, proton transmembrane transport, regulation of lysosomal lumen pH; MF: arachidonate binding, potassium channel activity, potassium ion leak channel activity, proton channel activity; CC: endosome, endosome membrane, lysosomal membrane, lysosome, membrane
Pathways:
UniProt: Q9CXY1
Entrez ID: 72392
|
Does Knockout of Ints14 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Ints14
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ints14 (integrator complex subunit 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, snRNA 3'-end processing, snRNA processing; MF: metal ion binding, molecular_function; CC: INTAC complex, integrator complex, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q8R3P6
Entrez ID: 69882
|
Does Knockout of Cacna1h in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Cacna1h
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cacna1h (calcium channel, voltage-dependent, T type, alpha 1H subunit)
Type: protein-coding
Summary: Voltage-dependent Ca(2+) channels mediate the entry of Ca(2+) ions into excitable cells and are involved in a variety of Ca(2+)-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. The protein encoded by this gene is an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: aldosterone biosynthetic process, calcium ion import, calcium ion transmembrane transport, calcium ion transport, cortisol biosynthetic process, inorganic cation transmembrane transport, membrane depolarization during action potential, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of acrosome reaction, positive regulation of calcium ion-dependent exocytosis, positive regulation of cardiac muscle cell contraction, regulation of membrane potential, sodium ion transmembrane transport, transmembrane transport; MF: calcium channel activity, low voltage-gated calcium channel activity, metal ion binding, monoatomic ion channel activity, protein binding, scaffold protein binding, voltage-gated calcium channel activity, voltage-gated monoatomic ion channel activity, voltage-gated sodium channel activity; CC: caveola, dendrite, glutamatergic synapse, membrane, monoatomic ion channel complex, neuron projection, perikaryon, plasma membrane, postsynaptic membrane, presynaptic active zone membrane, sarcolemma, voltage-gated calcium channel complex, voltage-gated sodium channel complex
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse)
UniProt: E0CYZ3, E9Q6P9, Q3UX23, A0AAA9WW37, Q9JJ85, A0AAA9WUV6, F6U5P7, F6USE5
Entrez ID: 58226
|
Does Knockout of Txnrd1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Txnrd1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Txnrd1 (thioredoxin reductase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, May 2017].
Gene Ontology: BP: benzene-containing compound metabolic process, cell population proliferation, cell redox homeostasis, cellular oxidant detoxification, gastrulation, hydrogen peroxide catabolic process, mesoderm formation, positive regulation of apoptotic process, response to oxidative stress, selenocysteine metabolic process; MF: FAD binding, NAD(P)H oxidase H2O2-forming activity, NADPH peroxidase activity, flavin adenine dinucleotide binding, identical protein binding, mercury ion binding, oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor, selenate reductase activity, thioredoxin-disulfide reductase (NADPH) activity; CC: cytoplasm, cytosol, fibrillar center, mitochondrion, neuronal cell body, nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of amino acids and derivatives, Metabolism of ingested MeSeO2H into MeSeH, Metabolism of nucleotides, Pathways in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Selenoamino acid metabolism, Selenocompound metabolism - Mus musculus (mouse), TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, thioredoxin pathway
UniProt: Q9JMH6
Entrez ID: 50493
|
Does Knockout of Rbm18 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Rbm18
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rbm18 (RNA binding motif protein 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: cytosol, intercellular bridge, nucleoplasm
Pathways:
UniProt: Q9CR83
Entrez ID: 67889
|
Does Knockout of Rbm25 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Rbm25
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Rbm25 (RNA binding motif protein 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic process, mRNA processing, regulation of alternative mRNA splicing, via spliceosome, regulation of apoptotic process; MF: RNA binding, mRNA binding, nucleic acid binding; CC: cytoplasm, nuclear speck, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: B2RY56
Entrez ID: 67039
|
Does Knockout of Leo1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Leo1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Leo1 (Leo1, Paf1/RNA polymerase II complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, endodermal cell fate commitment, mRNA 3'-end processing, negative regulation of myeloid cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II; MF: RNA polymerase II C-terminal domain phosphoserine binding, protein binding; CC: Cdc73/Paf1 complex, centrosome, fibrillar center, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Formation of RNA Pol II elongation complex , Formation of the beta-catenin:TCF transactivating complex, Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q5XJE5
Entrez ID: 235497
|
Does Knockout of Edem2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,157
|
Knockout
|
Edem2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Edem2 (ER degradation enhancer, mannosidase alpha-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, carbohydrate metabolic process, endoplasmic reticulum mannose trimming, endoplasmic reticulum unfolded protein response, positive regulation of retrograde protein transport, ER to cytosol, response to unfolded protein, ubiquitin-dependent glycoprotein ERAD pathway; MF: calcium ion binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum quality control compartment, membrane
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q8BJT9
Entrez ID: 108687
|
Does Knockout of Tcp1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Tcp1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tcp1 (t-complex protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of establishment of protein localization to telomere, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, scaRNA localization to Cajal body; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, ubiquitin protein ligase binding, unfolded protein binding; CC: Golgi apparatus, acrosomal vesicle, cell body, centrosome, chaperonin-containing T-complex, cytoplasm, cytoskeleton, cytosol, heterochromatin, microtubule, microtubule organizing center, myelin sheath, pericentriolar material, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: P11983
Entrez ID: 21454
|
Does Knockout of Cdt1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Cdt1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cdt1 (chromatin licensing and DNA replication factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA replication checkpoint signaling, DNA replication preinitiation complex assembly, attachment of mitotic spindle microtubules to kinetochore, mitotic cell cycle, negative regulation of DNA-templated DNA replication, negative regulation of cell cycle, positive regulation of DNA replication, positive regulation of DNA-templated DNA replication, regulation of DNA-templated DNA replication initiation, regulation of nuclear cell cycle DNA replication, response to sorbitol; MF: DNA binding, DNA polymerase binding, chromatin binding, protein binding; CC: chromosome, chromosome, centromeric region, kinetochore, nuclear body, nucleoplasm, nucleus
Pathways: Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: Q8R4E9
Entrez ID: 67177
|
Does Knockout of Vmn1r196 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Vmn1r196
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vmn1r196 (vomeronasal 1 receptor 196)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BQY1, Q5SVD5, A0A2I3BQ58
Entrez ID: 100312484
|
Does Knockout of Rptor in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Rptor
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rptor (regulatory associated protein of MTOR, complex 1)
Type: protein-coding
Summary: This gene encodes a subunit of mammalian target of rapamycin complex 1 (mTORC1), a component of the mTOR signaling pathway, which regulates cell growth in response to nutrient and energy levels. The encoded protein may regulate the assembly, localization, and substrate binding of the mTORC1 complex. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: DNA damage response, TOR signaling, TORC1 signaling, autophagosome assembly, cellular response to L-leucine, cellular response to amino acid stimulus, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to nutrient levels, cellular response to osmotic stress, cellular response to starvation, cytoplasmic translation, negative regulation of autophagy, negative regulation of insulin secretion, negative regulation of translational initiation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of cell growth, positive regulation of endothelial cell proliferation, positive regulation of glycolytic process, positive regulation of lipid biosynthetic process, positive regulation of odontoblast differentiation, positive regulation of osteoclast differentiation, positive regulation of pentose-phosphate shunt, positive regulation of transcription by RNA polymerase III, positive regulation of translational initiation, protein localization to lysosome, regulation of autophagy, regulation of biological quality, regulation of cell communication, regulation of cell growth, regulation of cell size, regulation of protein phosphorylation, regulation of signaling, response to xenobiotic stimulus, social behavior; MF: 14-3-3 protein binding, enzyme-substrate adaptor activity, protein binding, protein kinase activator activity, protein kinase binding, protein serine/threonine kinase inhibitor activity, protein-containing complex binding, protein-macromolecule adaptor activity, small GTPase binding; CC: TORC1 complex, cytoplasm, cytoplasmic stress granule, cytosol, dendrite, lysosomal membrane, lysosome, neuronal cell body, nucleoplasm, serine/threonine protein kinase complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: A4FUW1, A2ACM0, F7BQS0, F7B6I3, F7CN67, A0A991EQV1, F6U5L3, E9PXZ5
Entrez ID: 74370
|
Does Knockout of Parn in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Parn
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Parn (poly(A)-specific ribonuclease (deadenylation nuclease))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, box H/ACA sno(s)RNA 3'-end processing, lncRNA processing, mRNA catabolic process, miRNA catabolic process, negative regulation of macromolecule metabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA poly(A) tail shortening, poly(A)-dependent snoRNA 3'-end processing, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of telomere maintenance via telomerase, priRNA 3'-end processing, regulation of RNA stability, regulation of telomerase RNA localization to Cajal body, siRNA 3'-end processing, telomerase RNA stabilization; MF: 3'-5'-RNA exonuclease activity, RNA binding, cation binding, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, poly(A)-specific ribonuclease activity, protein binding, protein kinase binding, telomerase RNA binding; CC: cytoplasm, glutamatergic synapse, nuclear speck, nucleolus, nucleus, postsynapse
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Metabolism of RNA, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements
UniProt: Q8VDG3
Entrez ID: 74108
|
Does Knockout of Ceacam2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Ceacam2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ceacam2 (CEA cell adhesion molecule 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid and bile salt transport, cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, cellular response to insulin stimulus, energy homeostasis, homophilic cell adhesion via plasma membrane adhesion molecules, insulin catabolic process, insulin receptor internalization, negative regulation of brown fat cell proliferation, negative regulation of cell population proliferation, negative regulation of fatty acid biosynthetic process, negative regulation of feeding behavior, negative regulation of hepatocyte proliferation, positive regulation of homophilic cell adhesion, regulation of ERK1 and ERK2 cascade, regulation of cell growth, regulation of epidermal growth factor receptor signaling pathway, regulation of homophilic cell adhesion, regulation of immune system process, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, signal transduction; MF: GPI anchor binding, actin binding, bile acid transmembrane transporter activity, calmodulin binding, filamin binding, identical protein binding, kinase binding, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, protein kinase binding, protein phosphatase binding, protein tyrosine kinase binding, protein-containing complex binding; CC: T cell receptor complex, adherens junction, apical plasma membrane, basal plasma membrane, basolateral plasma membrane, cell junction, cell surface, cell-cell junction, cytosol, external side of plasma membrane, extracellular space, lateral plasma membrane, membrane, plasma membrane, transforming growth factor beta ligand-receptor complex
Pathways: Cell surface interactions at the vascular wall, Hemostasis, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q925P2
Entrez ID: 26367
|
Does Knockout of Tnfaip2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Tnfaip2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tnfaip2 (tumor necrosis factor, alpha-induced protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell differentiation, exocyst localization, exocytosis; CC: exocyst
Pathways:
UniProt: Q61333
Entrez ID: 21928
|
Does Knockout of Wfdc12 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Wfdc12
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Wfdc12 (WAP four-disulfide core domain 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, defense response to bacterium, innate immune response; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9JHY3
Entrez ID: 192200
|
Does Knockout of Dlec1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Dlec1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Dlec1 (deleted in lung and esophageal cancer 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, defense response to tumor cell, negative regulation of cell population proliferation, spermatogenesis; MF: alpha-tubulin binding, beta-tubulin binding; CC: cytoplasm, cytosol
Pathways:
UniProt: E9Q8C0, D3Z6E8, E9QNI0
Entrez ID: 320256
|
Does Knockout of Stard7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Stard7
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Stard7 (StAR related lipid transfer domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of skin barrier, inflammatory response, mucociliary clearance, myeloid dendritic cell activation, type 2 immune response; MF: lipid binding, molecular carrier activity; CC: cytoplasm, extracellular region, mitochondrion
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of cofactors, Metabolism of lipids, Metabolism of vitamins and cofactors, Phospholipid metabolism, Synthesis of PC, Ubiquinol biosynthesis
UniProt: Q8R1R3
Entrez ID: 99138
|
Does Knockout of Rpl36 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Rpl36
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rpl36 (ribosomal protein L36)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleolus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P47964
Entrez ID: 54217
|
Does Knockout of Jph4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Jph4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Jph4 (junctophilin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: learning, neuromuscular process controlling balance, regulation of biological quality, regulation of calcium ion transport, regulation of cytokine production, regulation of store-operated calcium entry, regulation of synaptic plasticity; CC: dendritic shaft, endoplasmic reticulum, endoplasmic reticulum membrane, junctional membrane complex, membrane, plasma membrane, smooth endoplasmic reticulum
Pathways:
UniProt: Q80WT0
Entrez ID: 319984
|
Does Knockout of Sbk1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Sbk1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Sbk1 (SH3-binding kinase 1)
Type: protein-coding
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SBK1 (SH3 domain binding kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cellular_component, cytoplasm
Pathways:
UniProt: Q8QZX0
Entrez ID: 104175
|
Does Knockout of Fanca in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Fanca
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fanca (Fanconi anemia, complementation group A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, female gonad development, interstrand cross-link repair, male gonad development, male meiotic nuclear division, regulation of CD40 signaling pathway, regulation of germ cell proliferation, regulation of inflammatory response, regulation of regulatory T cell differentiation; CC: Fanconi anaemia nuclear complex, chromatin, cytoplasm, nucleoplasm, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: Q9JL70
Entrez ID: 14087
|
Does Knockout of Msh2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Msh2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Msh2 (mutS homolog 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, B cell mediated immunity, DNA damage response, DNA repair, determination of adult lifespan, developmental process involved in reproduction, double-strand break repair, gamete generation, germ cell development, in utero embryonic development, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, isotype switching, maintenance of DNA repeat elements, male gonad development, mismatch repair, mitotic intra-S DNA damage checkpoint signaling, mitotic recombination, negative regulation of DNA recombination, negative regulation of neuron apoptotic process, oxidative phosphorylation, positive regulation of isotype switching to IgA isotypes, positive regulation of isotype switching to IgG isotypes, postreplication repair, regulation of cell cycle, response to UV-B, response to X-ray, somatic hypermutation of immunoglobulin genes, somatic recombination of immunoglobulin gene segments, somatic recombination of immunoglobulin genes involved in immune response; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent DNA damage sensor activity, ATP-dependent activity, acting on DNA, DNA binding, MutLalpha complex binding, centromeric DNA binding, chromatin binding, damaged DNA binding, dinucleotide insertion or deletion binding, dinucleotide repeat insertion binding, double-stranded DNA binding, enzyme activator activity, four-way junction DNA binding, guanine/thymine mispair binding, magnesium ion binding, mismatched DNA binding, nucleotide binding, oxidized purine DNA binding, protein homodimerization activity, single guanine insertion binding, single thymine insertion binding, single-stranded DNA binding; CC: MutSalpha complex, MutSbeta complex, chromosome, nucleoplasm, nucleus
Pathways: Colorectal cancer - Mus musculus (mouse), DNA Repair, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: P43247
Entrez ID: 17685
|
Does Knockout of Lhx5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Lhx5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Lhx5 (LIM homeobox protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell proliferation in forebrain, cell-cell signaling, cerebellar Purkinje cell differentiation, cerebellar Purkinje cell-granule cell precursor cell signaling, cerebellum development, forebrain neuron differentiation, hippocampus development, neuroblast proliferation, neuron differentiation, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of cerebellar granule cell precursor proliferation, regulation of neuroblast proliferation, regulation of transcription by RNA polymerase II, spinal cord association neuron differentiation; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: P61375
Entrez ID: 16873
|
Does Knockout of Psmc3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Psmc3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Psmc3 (proteasome (prosome, macropain) 26S subunit, ATPase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, host-mediated perturbation of viral transcription, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATP binding, ATP hydrolysis activity, identical protein binding, nucleotide binding, proteasome-activating activity; CC: P-body, cytoplasm, nucleus, perinuclear region of cytoplasm, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: O88685
Entrez ID: 19182
|
Does Knockout of Chchd4 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Chchd4
|
phagocytosis
|
macrophage
|
Gene: Chchd4 (coiled-coil-helix-coiled-coil-helix domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to leukemia inhibitory factor, cellular response to oxidative stress, establishment of protein localization to mitochondrion, mitochondrial DNA repair, mitochondrial disulfide relay system, mitochondrial respiratory chain complex assembly, positive regulation of cellular respiration, protein import into mitochondrial intermembrane space, protein maturation, protein transport, regulation of protein export from nucleus; MF: oxidoreductase activity, protein binding, protein-disulfide reductase activity; CC: mitochondrial intermembrane space, mitochondrion
Pathways:
UniProt: Q8VEA4
Entrez ID: 72170
|
Does Knockout of Ddx28 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ddx28
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ddx28 (DEAD box helicase 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial large ribosomal subunit assembly, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, rRNA binding; CC: cytosol, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleolus, nucleoplasm, nucleus, ribonucleoprotein granule
Pathways:
UniProt: Q9CWT6
Entrez ID: 71986
|
Does Knockout of Dpysl3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Dpysl3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dpysl3 (dihydropyrimidinase-like 3)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: actin crosslink formation, actin filament bundle assembly, cellular response to cytokine stimulus, negative regulation of cell migration, negative regulation of neuron projection development, nervous system development, neuron development, positive regulation of filopodium assembly, positive regulation of neuron projection development, pyrimidine nucleobase catabolic process, response to axon injury; MF: SH3 domain binding, chondroitin sulfate binding, dihydropyrimidinase activity, filamin binding, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, identical protein binding, phosphoprotein binding, protein binding; CC: cell body, cell projection, cytoplasm, cytosol, exocytic vesicle, extracellular space, filamentous actin, growth cone, lamellipodium, synapse
Pathways: Axon guidance, CRMPs in Sema3A signaling, Developmental Biology, Nervous system development, Semaphorin interactions
UniProt: Q62188
Entrez ID: 22240
|
Does Knockout of Itpripl1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Itpripl1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Itpripl1 (inositol 1,4,5-triphosphate receptor interacting protein-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, T cell differentiation, T cell receptor signaling pathway, biological_process, calcium ion import, negative regulation of T cell receptor signaling pathway, negative regulation of signal transduction, positive regulation of MAPK cascade, signal transduction; MF: molecular_function, protein binding, receptor ligand activity; CC: membrane, plasma membrane
Pathways:
UniProt: A2ASA8
Entrez ID: 73338
|
Does Knockout of Gprc5b in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Gprc5b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gprc5b (G protein-coupled receptor, family C, group 5, member B)
Type: protein-coding
Summary: Enables protein kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of neuron differentiation; and positive regulation of signal transduction. Acts upstream of or within several processes, including glucose homeostasis; positive regulation of neuron projection development; and positive regulation of protein kinase activity. Located in cell surface. Is active in membrane raft. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts. Orthologous to human GPRC5B (G protein-coupled receptor class C group 5 member B). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell volume homeostasis, glucose homeostasis, locomotory behavior, positive regulation of canonical NF-kappaB signal transduction, positive regulation of canonical Wnt signaling pathway, positive regulation of inflammatory response, positive regulation of macrophage cytokine production, positive regulation of neuron differentiation, positive regulation of neuron projection development, positive regulation of protein tyrosine kinase activity, signal transduction; MF: G protein-coupled receptor activity, protein kinase activator activity, protein kinase binding, protein kinase inhibitor activity; CC: cell surface, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, extracellular exosome, intracellular membrane-bounded organelle, membrane, membrane raft, nucleolus, nucleoplasm, plasma membrane, receptor complex
Pathways:
UniProt: Q923Z0
Entrez ID: 64297
|
Does Knockout of Gbp2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Gbp2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Gbp2 (guanylate binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AIM2 inflammasome complex assembly, activation of innate immune response, adhesion of symbiont to host, cellular response to interferon-beta, cellular response to lipopolysaccharide, cellular response to type II interferon, cytolysis in another organism, defense response to Gram-positive bacterium, defense response to bacterium, defense response to protozoan, defense response to virus, disruption of plasma membrane integrity in another organism, immune system process, innate immune response, non-canonical inflammasome complex assembly, positive regulation of AIM2 inflammasome complex assembly, positive regulation of pyroptotic inflammatory response, protein targeting, regulation of defense response, response to bacterium; MF: G protein activity, GDP binding, GDP phosphatase activity, GTP binding, GTPase activity, GTPase regulator activity, Hsp90 protein binding, actin binding, cytokine binding, endopeptidase inhibitor activity, enzyme binding, hydrolase activity, identical protein binding, lipopolysaccharide binding, molecular function inhibitor activity, nucleotide binding, protein homodimerization activity, spectrin binding; CC: Golgi apparatus, Golgi membrane, actin cytoskeleton, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, symbiont cell surface, symbiont-containing vacuole membrane, vesicle membrane
Pathways: NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q9Z0E6
Entrez ID: 14469
|
Does Knockout of Rbm17 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Rbm17
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rbm17 (RNA binding motif protein 17)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Located in nucleus. Part of protein-containing complex. Is expressed in brain; cerebral cortex; hippocampus; ovary; and primary sex cord. Orthologous to human RBM17 (RNA binding motif protein 17). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, alternative mRNA splicing, via spliceosome, mRNA cis splicing, via spliceosome, mRNA processing; MF: RNA binding, nucleic acid binding, protein binding; CC: nucleoplasm, nucleus, protein-containing complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8JZX4
Entrez ID: 76938
|
Does Knockout of Uck1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Uck1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Uck1 (uridine-cytidine kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP biosynthetic process, CTP salvage, UMP salvage; MF: ATP binding, cytidine kinase activity, kinase activity, nucleotide binding, transferase activity, uridine kinase activity
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide salvage, Pyrimidine metabolism - Mus musculus (mouse), Pyrimidine salvage, purine and pyrimidine metabolism, salvage pathways of pyrimidine ribonucleotides
UniProt: P52623
Entrez ID: 22245
|
Does Knockout of Ipo4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Ipo4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ipo4 (importin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, nucleocytoplasmic transport, protein import into nucleus, protein localization to nucleus, protein transport, ribosome biogenesis; MF: nuclear import signal receptor activity, nuclear localization sequence binding, protein binding, small GTPase binding; CC: chromatin, cytoplasm, nucleus, protein-containing complex
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q8VI75
Entrez ID: 75751
|
Does Knockout of Rab22a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Rab22a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rab22a (RAB22A, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytosis, endosome organization, intracellular protein transport, protein transport, regulation of vesicle size; MF: G protein activity, GDP binding, GTP binding, GTPase activity, nucleotide binding, protein binding; CC: Golgi apparatus, actin cytoskeleton, cell projection, cytoplasmic vesicle, early endosome, endomembrane system, endosome, endosome membrane, late endosome, membrane, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, ruffle
Pathways: Endocytosis - Mus musculus (mouse), Metabolism of proteins, Post-translational protein modification, RAB geranylgeranylation
UniProt: P35285
Entrez ID: 19334
|
Does Knockout of Cyc1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Cyc1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cyc1 (cytochrome c-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, proton transmembrane transport, response to glucagon; MF: electron transfer activity, heme binding, metal ion binding, protein binding, quinol-cytochrome-c reductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex III assembly, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9D0M3
Entrez ID: 66445
|
Does Knockout of Ptgr1 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Ptgr1
|
cell proliferation
|
Regulatory T cell
|
Gene: Ptgr1 (prostaglandin reductase 1)
Type: protein-coding
Summary: Predicted to enable 13-lipoxin reductase activity; leukotriene B4 12-hydroxy dehydrogenase activity; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of positive chemotaxis; and negative regulation of reactive oxygen species biosynthetic process. Predicted to be located in cytosol and nucleus. Is expressed in genitourinary system. Orthologous to human PTGR1 (prostaglandin reductase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: alkene metabolic process, fatty acid metabolic process, leukotriene B4 metabolic process, lipid metabolic process, lipoxin A4 metabolic process, negative regulation of positive chemotaxis, negative regulation of reactive oxygen species biosynthetic process, prostaglandin metabolic process; MF: 13-lipoxin reductase activity, 15-oxoprostaglandin 13-reductase [NAD(P)+] activity, 2-alkenal reductase (NADPH) activity, 2-alkenal reductase [NAD(P)H] activity, leukotriene B4 12-hydroxy dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; CC: cytoplasm, cytosol, nucleus
Pathways: sphingosine and sphingosine-1-phosphate metabolism
UniProt: Q91YR9
Entrez ID: 67103
|
Does Knockout of Inpp4b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Inpp4b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Inpp4b (inositol polyphosphate-4-phosphatase, type II)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular calcium ion homeostasis, lipid metabolic process, negative regulation of osteoclast differentiation, phosphatidylinositol dephosphorylation, phosphatidylinositol-3-phosphate biosynthetic process, regulation of bone remodeling, regulation of nucleocytoplasmic transport, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: hydrolase activity, inositol-1,3,4-trisphosphate 4-phosphatase activity, inositol-3,4-bisphosphate 4-phosphatase activity, lipid binding, phosphatase activity, phosphatidylinositol bisphosphate phosphatase activity, phosphatidylinositol trisphosphate phosphatase activity, phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
Pathways: Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Synthesis of IP2, IP, and Ins in the cytosol, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the plasma membrane
UniProt: Q6P1Y8
Entrez ID: 234515
|
Does Knockout of Syce1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Syce1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Syce1 (synaptonemal complex central element protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, meiotic cell cycle, synaptonemal complex assembly, synaptonemal complex organization; CC: central element, chromosome, nucleoplasm, nucleus, synaptonemal complex
Pathways:
UniProt: Q9D495
Entrez ID: 74075
|
Does Knockout of Prrc2c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Prrc2c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prrc2c (proline-rich coiled-coil 2C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hematopoietic progenitor cell differentiation, stress granule assembly; CC: cytoplasm, cytoplasmic stress granule, cytosol
Pathways:
UniProt: Q3TLH4
Entrez ID: 226562
|
Does Knockout of Ethe1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Ethe1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Ethe1 (ethylmalonic encephalopathy 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity; iron ion binding activity; and sulfur dioxygenase activity. Predicted to be involved in glutathione metabolic process and hydrogen sulfide metabolic process. Located in mitochondrion. Is expressed in gallbladder; genitourinary system; gut; nervous system; and vascular system. Used to study ethylmalonic encephalopathy. Human ortholog(s) of this gene implicated in ethylmalonic encephalopathy. Orthologous to human ETHE1 (ETHE1 persulfide dioxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: glutathione metabolic process, hydrogen sulfide metabolic process; MF: dioxygenase activity, identical protein binding, iron ion binding, metal ion binding, oxidoreductase activity, sulfur dioxygenase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion, nucleoplasm, nucleus
Pathways: Degradation of cysteine and homocysteine, Metabolism, Metabolism of amino acids and derivatives, Sulfide oxidation to sulfate, Sulfur amino acid metabolism, Sulfur metabolism - Mus musculus (mouse)
UniProt: Q9DCM0
Entrez ID: 66071
|
Does Knockout of Taf2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Taf2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Taf2 (TATA-box binding protein associated factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, RNA polymerase II preinitiation complex assembly, mRNA transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription initiation by RNA polymerase II, regulation of DNA repair, regulation of transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: RNA polymerase II general transcription initiation factor activity, chromatin binding, transcription cis-regulatory region binding; CC: nucleus, transcription factor TFIID complex, transcription factor TFTC complex
Pathways: Basal transcription factors - Mus musculus (mouse)
UniProt: B9EJX5
Entrez ID: 319944
|
Does Knockout of Scn5a in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Scn5a
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Scn5a (sodium channel, voltage-gated, type V, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AV node cell action potential, AV node cell to bundle of His cell communication, SA node cell action potential, animal organ development, atrial cardiac muscle cell action potential, bundle of His cell action potential, cardiac muscle cell action potential involved in contraction, cardiac muscle contraction, cardiac ventricle development, cell communication involved in cardiac conduction, cellular response to calcium ion, establishment of localization in cell, membrane depolarization, membrane depolarization during AV node cell action potential, membrane depolarization during Purkinje myocyte cell action potential, membrane depolarization during SA node cell action potential, membrane depolarization during action potential, membrane depolarization during atrial cardiac muscle cell action potential, membrane depolarization during bundle of His cell action potential, membrane depolarization during cardiac muscle cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, neuronal action potential, positive regulation of action potential, positive regulation of epithelial cell proliferation, positive regulation of heart rate, positive regulation of sodium ion transport, regulation of atrial cardiac muscle cell membrane depolarization, regulation of atrial cardiac muscle cell membrane repolarization, regulation of cardiac muscle cell contraction, regulation of heart rate, regulation of heart rate by cardiac conduction, regulation of muscle system process, regulation of sodium ion transmembrane transport, regulation of ventricular cardiac muscle cell membrane depolarization, regulation of ventricular cardiac muscle cell membrane repolarization, response to denervation involved in regulation of muscle adaptation, sensory perception of pain, sodium ion import across plasma membrane, sodium ion transmembrane transport, sodium ion transport, system development, transmembrane transport, ventricular cardiac muscle cell action potential; MF: ankyrin binding, calmodulin binding, enzyme binding, fibroblast growth factor binding, monoatomic cation channel activity, monoatomic ion channel activity, nitric-oxide synthase binding, protein binding, protein domain specific binding, protein kinase binding, scaffold protein binding, sodium channel activity, transmembrane transporter binding, ubiquitin protein ligase binding, voltage-gated sodium channel activity, voltage-gated sodium channel activity involved in AV node cell action potential, voltage-gated sodium channel activity involved in Purkinje myocyte action potential, voltage-gated sodium channel activity involved in SA node cell action potential, voltage-gated sodium channel activity involved in bundle of His cell action potential, voltage-gated sodium channel activity involved in cardiac muscle cell action potential; CC: T-tubule, Z disc, anchoring junction, axon, caveola, cell surface, cytoplasm, endoplasmic reticulum, intercalated disc, lateral plasma membrane, membrane, monoatomic ion channel complex, nucleolus, nucleoplasm, perinuclear region of cytoplasm, plasma membrane, sarcolemma, sodium channel complex, voltage-gated sodium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse)
UniProt: Q9JJV9
Entrez ID: 20271
|
Does Knockout of Eml3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Eml3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Eml3 (echinoderm microtubule associated protein like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule cytoskeleton organization, mitotic metaphase chromosome alignment, regulation of mitotic spindle assembly; CC: cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, midbody, mitotic spindle, mitotic spindle microtubule, nucleus, spindle, spindle microtubule
Pathways:
UniProt: Q8VC03
Entrez ID: 225898
|
Does Knockout of Tlr2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Tlr2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tlr2 (toll-like receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MyD88-dependent toll-like receptor signaling pathway, cell surface pattern recognition receptor signaling pathway, cellular response to bacterial lipopeptide, cellular response to diacyl bacterial lipopeptide, cellular response to lipoteichoic acid, cellular response to peptidoglycan, cellular response to triacyl bacterial lipopeptide, cellular response to type II interferon, central nervous system myelin formation, defense response, defense response to Gram-positive bacterium, detection of diacyl bacterial lipopeptide, detection of triacyl bacterial lipopeptide, immune response, immune system process, inflammatory response, innate immune response, learning, leukotriene metabolic process, microglia development, microglial cell activation, negative regulation of actin filament polymerization, negative regulation of cell population proliferation, negative regulation of interleukin-12 production, negative regulation of interleukin-17 production, negative regulation of phagocytosis, negative regulation of synapse assembly, nitric oxide metabolic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of Wnt signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, positive regulation of cellular response to macrophage colony-stimulating factor stimulus, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of gene expression, positive regulation of inflammatory response, positive regulation of interferon-beta production, positive regulation of interleukin-1 beta production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-18 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of intracellular signal transduction, positive regulation of leukocyte migration, positive regulation of macrophage cytokine production, positive regulation of matrix metallopeptidase secretion, positive regulation of neuron projection development, positive regulation of neutrophil migration, positive regulation of nitric oxide biosynthetic process, positive regulation of oligodendrocyte differentiation, positive regulation of phagocytosis, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of striated muscle cell apoptotic process, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of vascular associated smooth muscle cell migration, positive regulation of xenophagy, regulation of dendritic cell cytokine production, regulation of tumor necrosis factor production, response to bacterial lipoprotein, response to bacterium, response to fatty acid, response to molecule of fungal origin, response to peptidoglycan, signal transduction, toll-like receptor 2 signaling pathway, toll-like receptor TLR6:TLR2 signaling pathway, toll-like receptor signaling pathway; MF: NAD+ nucleosidase activity, cyclic ADP-ribose generating, Toll-like receptor binding, amyloid-beta binding, diacyl lipopeptide binding, identical protein binding, lipopeptide binding, lipopolysaccharide binding, lipoteichoic acid binding, pattern recognition receptor activity, peptidoglycan binding, protein binding, protein-containing complex binding, signaling receptor activity, transmembrane signaling receptor activity, triacyl lipopeptide binding; CC: Golgi apparatus, Toll-like receptor 1-Toll-like receptor 2 protein complex, Toll-like receptor 2-Toll-like receptor 6 protein complex, cell body, cell projection, cell surface, cytoplasm, cytoplasmic vesicle, cytosol, external side of plasma membrane, membrane, membrane raft, nucleoplasm, phagocytic vesicle membrane, plasma membrane, receptor complex
Pathways: Amoebiasis - Mus musculus (mouse), Antimicrobial peptides, Beta defensins, Chagas disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Defensins, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Innate Immune System, Legionellosis - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Malaria - Mus musculus (mouse), Measles - Mus musculus (mouse), Neutrophil degranulation, Neutrophil extracellular trap formation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of TLR by endogenous ligand, Rheumatoid arthritis - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q9QUN7
Entrez ID: 24088
|
Does Knockout of Prr14l in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Prr14l
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Prr14l (proline rich 14-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q7C4, Q6UDR4, Q3UYV6, H3BKZ4, F6RN94
Entrez ID: 215476
|
Does Knockout of Slc38a5 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Slc38a5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc38a5 (solute carrier family 38, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alanine transmembrane transport, L-glutamine import across plasma membrane, L-histidine transmembrane transport, L-serine import across plasma membrane, L-serine transport, amino acid export across plasma membrane, amino acid import across plasma membrane, asparagine transmembrane transport, asparagine transport, glutamine transport, glycine transport, neutral amino acid transport, serine transport, sodium ion transmembrane transport; MF: L-asparagine transmembrane transporter activity, L-glutamine transmembrane transporter activity, L-glutamine, sodium:proton antiporter activity, L-histidine transmembrane transporter activity, L-serine transmembrane transporter activity, alanine transmembrane transporter activity, amino acid transmembrane transporter activity, glycine transmembrane transporter activity, neutral L-amino acid transmembrane transporter activity, neutral amino acid, sodium:proton antiporter activity; CC: membrane, plasma membrane
Pathways: Amino acid transport across the plasma membrane, GABAergic synapse - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transport of small molecules
UniProt: Q3U1J0
Entrez ID: 209837
|
Does Knockout of Spata20 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Spata20
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Spata20 (spermatogenesis associated 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cell differentiation, spermatogenesis
Pathways:
UniProt: Q80YT5
Entrez ID: 217116
|
Does Knockout of Bace1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Bace1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Bace1 (beta-site APP cleaving enzyme 1)
Type: protein-coding
Summary: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: ERBB2-ERBB4 signaling pathway, amyloid precursor protein catabolic process, amyloid-beta formation, amyloid-beta metabolic process, cellular response to amyloid-beta, cellular response to copper ion, cellular response to manganese ion, detection of mechanical stimulus involved in sensory perception of pain, membrane protein ectodomain proteolysis, memory, modulation of chemical synaptic transmission, positive regulation of neuron apoptotic process, prepulse inhibition, presynaptic modulation of chemical synaptic transmission, protein processing, proteolysis, regulation of neuron apoptotic process, regulation of synaptic plasticity, response to insulin-like growth factor stimulus, response to lead ion, signaling receptor ligand precursor processing, swimming behavior; MF: amyloid-beta binding, aspartic-type endopeptidase activity, endopeptidase activity, enzyme binding, hydrolase activity, peptidase activity, protein binding, protein serine/threonine kinase binding; CC: Golgi apparatus, axon, cell projection, cell surface, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendrite, early endosome, endoplasmic reticulum, endosome, hippocampal mossy fiber to CA3 synapse, late endosome, lysosome, membrane, membrane raft, multivesicular body, neuronal cell body, plasma membrane, presynapse, recycling endosome, synaptic vesicle, trans-Golgi network
Pathways: Alzheimer disease - Mus musculus (mouse)
UniProt: P56818
Entrez ID: 23821
|
Does Knockout of Nsd2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Nsd2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nsd2 (nuclear receptor binding SET domain protein 2)
Type: protein-coding
Summary: Enables chromatin binding activity; histone H3K36 trimethyltransferase activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including bone development; cardiac septum morphogenesis; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Wolf-Hirschhorn syndrome. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: atrial septum primum morphogenesis, atrial septum secundum morphogenesis, bone development, chromatin organization, chromatin remodeling, membranous septum morphogenesis, methylation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of isotype switching to IgA isotypes, regulation of DNA-templated transcription, regulation of double-strand break repair via nonhomologous end joining, regulation of establishment of protein localization; MF: DNA binding, chromatin binding, histone H3K36 dimethyltransferase activity, histone H3K36 methyltransferase activity, histone H3K36 trimethyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, protein binding, sequence-specific DNA binding, transferase activity, zinc ion binding; CC: chromatin, chromosome, nucleolus, nucleoplasm, nucleus
Pathways: Lysine degradation - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q8BVE8
Entrez ID: 107823
|
Does Knockout of Hinfp in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Hinfp
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Hinfp (histone H4 transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA repair, DNA-templated transcription, G1/S transition of mitotic cell cycle, cell cycle G1/S phase transition, establishment of protein localization, in utero embryonic development, myoblast differentiation, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, enzyme binding, histone binding, metal ion binding, transcription cis-regulatory region binding, zinc ion binding; CC: Cajal body, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8K1K9
Entrez ID: 102423
|
Does Knockout of Mrpl14 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Mrpl14
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Mrpl14 (mitochondrial ribosomal protein L14)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL14 (mitochondrial ribosomal protein L14). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation, translation; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D1I6
Entrez ID: 68463
|
Does Knockout of Pdcd2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Pdcd2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pdcd2 (programmed cell death 2)
Type: protein-coding
Summary: Predicted to enable enzyme binding activity. Predicted to be involved in positive regulation of apoptotic process; positive regulation of hematopoietic stem cell proliferation; and regulation of hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in cranial ganglion; cranial nerve; and dorsal root ganglion. Orthologous to human PDCD2 (programmed cell death 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, positive regulation of apoptotic process, positive regulation of hematopoietic stem cell proliferation, programmed cell death, regulation of hematopoietic progenitor cell differentiation; MF: DNA binding, enzyme binding, metal ion binding, zinc ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: P46718
Entrez ID: 18567
|
Does Knockout of Hgs in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Hgs
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hgs (HGF-regulated tyrosine kinase substrate)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, endosome to lysosome transport, membrane invagination, negative regulation of angiogenesis, negative regulation of platelet-derived growth factor receptor signaling pathway, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of exosomal secretion, positive regulation of gene expression, protein localization to membrane, protein targeting to lysosome, protein transport, receptor internalization; MF: identical protein binding, metal ion binding, phosphatidylinositol binding, protein binding, protein domain specific binding, ubiquitin binding, ubiquitin-like protein ligase binding, ubiquitin-modified protein reader activity, zinc ion binding; CC: ESCRT-0 complex, cytoplasm, cytosol, early endosome, early endosome membrane, endosome, lysosome, membrane, multivesicular body membrane, secretory granule
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Deubiquitination, EGFR downregulation, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), Lysosome Vesicle Biogenesis, Membrane Trafficking, Metabolism of proteins, Negative regulation of MET activity, Phagosome - Mus musculus (mouse), Post-translational protein modification, RHO GTPase cycle, RHOBTB3 ATPase cycle, RHOU GTPase cycle, Signal Transduction, Signaling by EGFR, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Ub-specific processing proteases, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q99LI8
Entrez ID: 15239
|
Does Knockout of Dr1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Dr1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dr1 (down-regulator of transcription 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, general transcription initiation factor activity, protein binding, protein heterodimerization activity; CC: ATAC complex, RNA polymerase II transcription regulator complex, mitotic spindle, negative cofactor 2 complex, nucleoplasm, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription)
UniProt: Q91WV0
Entrez ID: 13486
|
Does Knockout of Pcdhga5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Pcdhga5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pcdhga5 (protocadherin gamma subfamily A, 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: Q91XY3
Entrez ID: 93713
|
Does Knockout of Bnipl in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Bnipl
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Bnipl (BCL2/adenovirus E1B 19kD interacting protein like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of cell population proliferation, regulation of growth rate; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q99JU7
Entrez ID: 171388
|
Does Knockout of Zfp934 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Zfp934
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Zfp934 (zinc finger protein 934)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: fibrillar center, microtubule cytoskeleton, nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: K7N6H3, A0A1Y7VKB4, A0A1Y7VJM8, Q8BSR1, A0A1Y7VM11, A0A1Y7VMB8, A0A1Y7VN06
Entrez ID: 77117
|
Does Knockout of Krtap4-16 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Krtap4-16
|
response to virus
|
Microglial Cell Line
|
Gene: Krtap4-16 (keratin associated protein 4-16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q91W93
Entrez ID: 435285
|
Does Knockout of Reep5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Reep5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Reep5 (receptor accessory protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, junctional sarcoplasmic reticulum membrane, membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways:
UniProt: G3X8R0, Q9CQG4, A0A494BB24, A0A494BBG4, A0A494BBE3
Entrez ID: 13476
|
Does Knockout of Garem1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Garem1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Garem1 (GRB2 associated regulator of MAPK1 subtype 1)
Type: protein-coding
Summary: Predicted to enable proline-rich region binding activity. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade. Is expressed in central nervous system; heart; lung; metanephros; and skeletal musculature. Orthologous to human GAREM1 (GRB2 associated regulator of MAPK1 subtype 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell population proliferation, cellular response to epidermal growth factor stimulus, epidermal growth factor receptor signaling pathway, multicellular organism growth, positive regulation of ERK1 and ERK2 cascade, positive regulation of cell division, positive regulation of cell population proliferation, response to epidermal growth factor; MF: proline-rich region binding
Pathways:
UniProt: Q3UFT3
Entrez ID: 381126
|
Does Knockout of Ssr1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ssr1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ssr1 (signal sequence receptor, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q9CY50
Entrez ID: 107513
|
Does Knockout of Cpq in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Cpq
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cpq (carboxypeptidase Q)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: peptide catabolic process, proteolysis, thyroid hormone generation, tissue regeneration; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallodipeptidase activity, metallopeptidase activity, peptidase activity, protein homodimerization activity; CC: Golgi apparatus, cytoplasm, endoplasmic reticulum, extracellular region, extracellular space, lysosome
Pathways:
UniProt: Q9WVJ3
Entrez ID: 54381
|
Does Knockout of Slitrk4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Slitrk4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slitrk4 (SLIT and NTRK-like family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, behavioral fear response, cell population proliferation, long-term synaptic potentiation, memory, positive regulation of synapse assembly, regulation of synapse organization, smoothened signaling pathway; CC: glutamatergic synapse, membrane, plasma membrane
Pathways: Neuronal System, Protein-protein interactions at synapses, Receptor-type tyrosine-protein phosphatases
UniProt: Q810B8
Entrez ID: 245446
|
Does Knockout of Pik3r1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,174
|
Knockout
|
Pik3r1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, T follicular helper cell differentiation, cellular response to UV, cellular response to insulin stimulus, cytokine-mediated signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, glucose metabolic process, growth hormone receptor signaling pathway, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, interleukin-18-mediated signaling pathway, intracellular glucose homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, myeloid leukocyte migration, natural killer cell mediated cytotoxicity, negative regulation of apoptotic process, negative regulation of blood pressure, negative regulation of cell adhesion, negative regulation of cell-cell adhesion, negative regulation of cell-matrix adhesion, negative regulation of heart rate, negative regulation of multicellular organismal process, negative regulation of muscle cell apoptotic process, negative regulation of osteoclast differentiation, negative regulation of proteolysis, negative regulation of smooth muscle cell proliferation, negative regulation of stress fiber assembly, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol metabolic process, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, positive regulation of RNA splicing, positive regulation of cell migration, positive regulation of cellular component biogenesis, positive regulation of cellular component organization, positive regulation of endoplasmic reticulum unfolded protein response, positive regulation of filopodium assembly, positive regulation of focal adhesion disassembly, positive regulation of gene expression, positive regulation of lamellipodium assembly, positive regulation of leukocyte migration, positive regulation of myoblast differentiation, positive regulation of protein import into nucleus, positive regulation of smooth muscle cell proliferation, positive regulation of synapse assembly, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, protein import into nucleus, protein stabilization, protein transport, regulation of protein localization to plasma membrane, regulation of stress fiber assembly, regulation of toll-like receptor 4 signaling pathway, response to cAMP, response to endoplasmic reticulum stress, response to glucocorticoid, response to insulin, signal transduction; MF: 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, ATPase binding, ErbB-3 class receptor binding, GTPase activator activity, calmodulin binding, insulin binding, insulin receptor binding, insulin receptor substrate binding, insulin-like growth factor receptor binding, kinase activator activity, neurotrophin TRKA receptor binding, nuclear estrogen receptor binding, phosphatidylinositol 3-kinase regulator activity, phosphatidylinositol 3-kinase regulatory subunit binding, phosphoprotein binding, phosphotyrosine residue binding, platelet-derived growth factor receptor binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein kinase binding, protein phosphatase binding, receptor tyrosine kinase binding, signaling receptor binding, ubiquitin protein ligase binding; CC: cell-cell junction, cis-Golgi network, cytoplasm, cytosol, membrane, nucleus, perinuclear endoplasmic reticulum membrane, perinuclear region of cytoplasm, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA, protein-containing complex
Pathways: 3-phosphoinositide biosynthesis, AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), CD28 dependent PI3K/Akt signaling, CDC42 GTPase cycle, Carbohydrate digestion and absorption - Mus musculus (mouse), Cell surface interactions at the vascular wall, Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Co-stimulation by CD28, Co-stimulation by ICOS, Colorectal cancer - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), Downstream TCR signaling, Downstream signal transduction, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, ESR-mediated signaling, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Estrogen signaling pathway - Mus musculus (mouse), Extra-nuclear estrogen signaling, FLT3 Signaling, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G alpha (q) signalling events, GAB1 signalosome, GP1b-IX-V activation signalling, GPCR downstream signalling, GPVI-mediated activation cascade, Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Innate Immune System, Insulin receptor signalling cascade, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Interleukin-7 signaling, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, MET activates PI3K/AKT signaling, Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Metabolism, Metabolism of lipids, MicroRNAs in cancer - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI Metabolism, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K events in ERBB2 signaling, PI3K events in ERBB4 signaling, PI3K-Akt signaling pathway - Mus musculus (mouse), PI3K/AKT activation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP metabolism, PIP3 activates AKT signaling, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Prion disease - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RAF/MAP kinase cascade, RET signaling, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, RHOJ GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, RND1 GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Regulation of signaling by CBL, Relaxin signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Role of LAT2/NTAL/LAB on calcium mobilization, Role of phospholipids in phagocytosis, Signal Transduction, Signaling by ALK, Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by Erythropoietin, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by LTK, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Nuclear Receptors, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by VEGF, Signaling by the B Cell Receptor (BCR), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Synthesis of PIPs at the plasma membrane, T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling, TNF signaling pathway - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Tie2 Signaling, Toll-like receptor signaling pathway - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P26450
Entrez ID: 18708
|
Does Knockout of Tbc1d8b in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Tbc1d8b
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tbc1d8b (TBC1 domain family, member 8B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glomerular filtration, vesicle-mediated transport; MF: GTPase activator activity, calcium ion binding; CC: cytoplasm, cytosol
Pathways: Golgi Associated Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: A3KGB4
Entrez ID: 245638
|
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