prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Ralgapa2 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Ralgapa2
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Ralgapa2 (Ral GTPase activating protein, alpha subunit 2 (catalytic))
Type: protein-coding
Summary: Enables GTPase activator activity. Acts upstream of or within several processes, including Ral protein signal transduction; activation of GTPase activity; and regulation of exocyst localization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in cochlea; diencephalon lateral wall ventricular layer; midbrain ventricular layer; olfactory cortex mantle layer; and olfactory epithelium. Orthologous to human RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Ral protein signal transduction, activation of GTPase activity, regulation of exocyst localization, regulation of protein localization, regulation of small GTPase mediated signal transduction; MF: GTPase activator activity, protein binding, protein heterodimerization activity; CC: cytoplasm, cytosol, nucleus, plasma membrane
Pathways:
UniProt: A3KGS3
Entrez ID: 241694
|
Does Knockout of Snu13 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Snu13
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Snu13 (SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, box C/D snoRNP assembly, mRNA processing, mRNA splicing, via spliceosome, maturation of SSU-rRNA, ribosomal small subunit biogenesis, ribosome biogenesis, single fertilization; MF: ATPase binding, RNA binding, U3 snoRNA binding, U4 snRNA binding, U4atac snRNA binding, box C/D sno(s)RNA binding, snoRNA binding; CC: U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U4atac snRNP, box C/D methylation guide snoRNP complex, dense fibrillar component, nucleolus, nucleus, plasma membrane, precatalytic spliceosome, protein-containing complex, ribonucleoprotein complex, small-subunit processome, spliceosomal complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D0T1
Entrez ID: 20826
|
Does Knockout of Id2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Id2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Id2 (inhibitor of DNA binding 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Peyer's patch development, adipose tissue development, adult locomotory behavior, bundle of His development, cell development, cell differentiation, cell maturation, cell morphogenesis involved in neuron differentiation, cellular response to lithium ion, cellular senescence, circadian regulation of gene expression, circadian rhythm, embryonic digestive tract morphogenesis, endodermal digestive tract morphogenesis, entrainment of circadian clock, entrainment of circadian clock by photoperiod, enucleate erythrocyte differentiation, epithelial cell differentiation involved in mammary gland alveolus development, heart development, leukocyte differentiation, locomotor rhythm, lymph node development, mammary gland alveolus development, mammary gland epithelial cell proliferation, membranous septum morphogenesis, metanephros development, natural killer cell differentiation, negative regulation of B cell differentiation, negative regulation of DNA-templated transcription, negative regulation of core promoter binding, negative regulation of dopaminergic neuron differentiation, negative regulation of gene expression, negative regulation of muscle cell differentiation, negative regulation of oligodendrocyte differentiation, negative regulation of osteoblast differentiation, negative regulation of transcription by RNA polymerase II, neuron differentiation, neuron fate commitment, olfactory bulb development, oligodendrocyte development, positive regulation of DNA-templated transcription, positive regulation of astrocyte differentiation, positive regulation of blood pressure, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of erythrocyte differentiation, positive regulation of fat cell differentiation, positive regulation of gene expression, positive regulation of macrophage differentiation, positive regulation of smooth muscle cell proliferation, regulation of G1/S transition of mitotic cell cycle, regulation of circadian rhythm, regulation of gene expression, regulation of lipid metabolic process, regulation of neural precursor cell proliferation, regulation of neuron differentiation, regulation of transcription by RNA polymerase II, rhythmic process, thigmotaxis, white fat cell differentiation; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, protein dimerization activity, transcription corepressor activity, transcription regulator inhibitor activity, transmembrane transporter binding; CC: chromatin, cytoplasm, cytosol, euchromatin, nucleus, protein-containing complex
Pathways: Hippo signaling pathway - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P41136
Entrez ID: 15902
|
Does Knockout of Lrrc36 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Lrrc36
|
cell cycle progression
|
breast epithelium
|
Gene: Lrrc36 (leucine rich repeat containing 36)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3V0M2
Entrez ID: 270091
|
Does Knockout of Ncln in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Ncln
|
cell cycle progression
|
breast epithelium
|
Gene: Ncln (nicalin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: multi-pass transmembrane protein insertion into ER membrane, protein stabilization, regulation of protein complex stability, regulation of protein-containing complex assembly, regulation of signal transduction; MF: ribosome binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, multi-pass translocon complex, protein-containing complex
Pathways:
UniProt: Q8VCM8
Entrez ID: 103425
|
Does Knockout of Vwa5b2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Vwa5b2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Vwa5b2 (von Willebrand factor A domain containing 5B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UR50
Entrez ID: 328643
|
Does Knockout of Igsf9b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Igsf9b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Igsf9b (immunoglobulin superfamily, member 9B)
Type: protein-coding
Summary: Enables kinase binding activity. Involved in synaptic membrane adhesion. Acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules and positive regulation of inhibitory postsynaptic potential. Located in dendrite; inhibitory synapse; and neuronal cell body. Is active in GABA-ergic synapse. Is expressed in hippocampus CA1 and thalamic nucleus. Orthologous to human IGSF9B (immunoglobulin superfamily member 9B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, nervous system development, positive regulation of inhibitory postsynaptic potential, synaptic membrane adhesion; MF: kinase binding, protein binding; CC: GABA-ergic synapse, dendrite, inhibitory synapse, membrane, neuron projection, neuronal cell body, plasma membrane, postsynaptic density, postsynaptic membrane, postsynaptic specialization of symmetric synapse, synapse
Pathways:
UniProt: A0A1L1SR84, D3Z169
Entrez ID: 235086
|
Does Knockout of Mcur1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Mcur1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mcur1 (mitochondrial calcium uniporter regulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium import into the mitochondrion, calcium ion import, calcium ion transmembrane transport, calcium ion transport, cell migration, cell population proliferation, establishment of localization in cell, generation of precursor metabolites and energy, mitochondrial calcium ion transmembrane transport, monoatomic ion transport, positive regulation of mitochondrial calcium ion concentration, protein heterooligomerization; MF: molecular_function, protein-containing complex binding, protein-macromolecule adaptor activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CXD6
Entrez ID: 76137
|
Does Knockout of Dph5 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Dph5
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Dph5 (diphthamide biosynthesis 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, protein histidyl modification to diphthamide; MF: diphthine methyl ester synthase activity, diphthine synthase activity, methyltransferase activity, transferase activity; CC: cellular_component, cytosol
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Synthesis of diphthamide-EEF2
UniProt: Q9CWQ0
Entrez ID: 69740
|
Does Knockout of Phpt1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Phpt1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Phpt1 (phosphohistidine phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, lamellipodium organization, negative regulation of T cell receptor signaling pathway, positive regulation of cell motility; MF: actin filament binding, calcium channel inhibitor activity, enzyme inhibitor activity, hydrolase activity, phosphoprotein phosphatase activity, protein histidine phosphatase activity, transmembrane transporter binding; CC: cytoplasm, cytosol, leading edge of lamellipodium, nuclear body, nucleoplasm, plasma membrane
Pathways:
UniProt: Q9DAK9
Entrez ID: 75454
|
Does Knockout of Sdr16c5 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Sdr16c5
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Sdr16c5 (short chain dehydrogenase/reductase family 16C, member 5)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; all-trans-retinol dehydrogenase (NAD+) activity; and transcription corepressor activity. Predicted to be involved in keratinocyte proliferation; negative regulation of macromolecule biosynthetic process; and retinoid metabolic process. Predicted to be located in chromatin; endoplasmic reticulum membrane; and nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in lipid droplet. Predicted to colocalize with endoplasmic reticulum and plasma membrane. Orthologous to human SDR16C5 (short chain dehydrogenase/reductase family 16C member 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: keratinocyte proliferation, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, retinal metabolic process, retinol metabolic process; MF: DNA-binding transcription factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, all-trans-retinol dehydrogenase (NAD+) activity, oxidoreductase activity, transcription corepressor activity; CC: chromatin, endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane, nucleus, plasma membrane, transcription repressor complex
Pathways: RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid
UniProt: Q7TQA3
Entrez ID: 242285
|
Does Knockout of Rab17 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Rab17
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Rab17 (RAB17, member RAS oncogene family)
Type: protein-coding
Summary: Predicted to enable GDP binding activity and GTPase activity. Involved in several processes, including immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; melanosome transport; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including brain; gut; metanephros; olfactory epithelium; and salivary gland primordium. Orthologous to human RAB17 (RAB17, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anterograde dendritic transport, cilium assembly, endocytic recycling, endocytosis, establishment of melanosome localization, filopodium assembly, immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor, intracellular protein transport, melanosome transport, plasma membrane bounded cell projection assembly, protein transport, regulation of dendrite development, regulation of filopodium assembly, regulation of synapse assembly, transcytosis; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: apical plasma membrane, basolateral plasma membrane, cell projection, cytoplasmic vesicle, dendrite, dendrite cytoplasm, early endosome, endocytic vesicle, endomembrane system, endosome, glutamatergic synapse, melanosome, membrane, neuronal cell body, plasma membrane, postsynapse, recycling endosome, recycling endosome membrane
Pathways: Metabolism of proteins, Post-translational protein modification, RAB geranylgeranylation
UniProt: P35292
Entrez ID: 19329
|
Does Knockout of Fer1l4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Fer1l4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fer1l4 (fer-1 like family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function; CC: cellular_component, membrane
Pathways:
UniProt: F6YZT0, Z4YL23, F6UNQ3
Entrez ID: 74562
|
Does Knockout of Fam53c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Fam53c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fam53c (family with sequence similarity 53, member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BXQ8
Entrez ID: 66306
|
Does Knockout of Setd1b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Setd1b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Setd1b (SET domain containing 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, methylation; MF: RNA binding, histone H3K4 methyltransferase activity, histone H3K4 monomethyltransferase activity, histone H3K4 trimethyltransferase activity, methyltransferase activity, nucleic acid binding, transferase activity; CC: Set1C/COMPASS complex, chromosome, cytoplasm, histone methyltransferase complex, nuclear speck, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Generic Transcription Pathway, Lysine degradation - Mus musculus (mouse), PKMTs methylate histone lysines, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Transcriptional regulation by RUNX1
UniProt: Q8CFT2
Entrez ID: 208043
|
Does Knockout of Prss22 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Prss22
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Prss22 (serine protease 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activator activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular space
Pathways:
UniProt: Q9ER10
Entrez ID: 70835
|
Does Knockout of Ager in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Ager
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Ager (advanced glycosylation end product-specific receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, astrocyte activation, astrocyte development, cell adhesion, cell surface receptor signaling pathway via JAK-STAT, cellular response to amyloid-beta, cellular response to oxygen-containing compound, glucose mediated signaling pathway, induction of positive chemotaxis, inflammatory response, learning or memory, microglial cell activation, negative regulation of blood circulation, negative regulation of cell adhesion, negative regulation of cell migration, negative regulation of collagen biosynthetic process, negative regulation of connective tissue replacement involved in inflammatory response wound healing, negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, negative regulation of interleukin-10 production, negative regulation of long-term synaptic depression, negative regulation of long-term synaptic potentiation, negative regulation of multicellular organismal process, negative regulation of signaling, neuron projection development, phagocytosis, positive regulation of DNA metabolic process, positive regulation of DNA-templated DNA replication, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of activated T cell proliferation, positive regulation of amyloid precursor protein catabolic process, positive regulation of apoptotic process, positive regulation of autophagy, positive regulation of cell migration, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of dendritic cell differentiation, positive regulation of double-strand break repair, positive regulation of endothelial cell apoptotic process, positive regulation of endothelin production, positive regulation of epithelial to mesenchymal transition, positive regulation of fibroblast migration, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of heterotypic cell-cell adhesion, positive regulation of interleukin-1 beta production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of locomotion, positive regulation of monocyte chemotactic protein-1 production, positive regulation of monocyte extravasation, positive regulation of neuron apoptotic process, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of p38MAPK cascade, positive regulation of phagocytosis, positive regulation of phagocytosis, engulfment, positive regulation of reactive oxygen species metabolic process, positive regulation of signaling, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of tumor necrosis factor production, positive regulation of type B pancreatic cell apoptotic process, protein localization to membrane, protein localization to plasma membrane, regulation of CD4-positive, alpha-beta T cell activation, regulation of T cell mediated cytotoxicity, regulation of inflammatory response, regulation of long-term synaptic potentiation, regulation of p38MAPK cascade, regulation of spontaneous synaptic transmission, response to amyloid-beta, response to hypoxia, transcytosis, transport across blood-brain barrier; MF: DNA binding, RNA binding, S100 protein binding, advanced glycation end-product binding, amyloid-beta binding, high mobility group box 1 binding, histone binding, identical protein binding, laminin receptor activity, molecular adaptor activity, protein binding, protein-containing complex binding, signaling receptor activity; CC: apical plasma membrane, axon, basal plasma membrane, cell junction, cell projection, cell surface, early endosome, endosome, external side of plasma membrane, extracellular region, extracellular space, fibrillar center, membrane, neuronal cell body, nucleus, phagocytic cup, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Advanced glycosylation endproduct receptor signaling, Alzheimer disease - Mus musculus (mouse), Cytokine Signaling in Immune system, DDX58/IFIH1-mediated induction of interferon-alpha/beta, Diabetic cardiomyopathy - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Lipid and atherosclerosis - Mus musculus (mouse), MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Neutrophil extracellular trap formation - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated NF-kB activation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q62151
Entrez ID: 11596
|
Does Knockout of Nr1h2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Nr1h2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nr1h2 (nuclear receptor subfamily 1, group H, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cholesterol homeostasis, hormone-mediated signaling pathway, intracellular receptor signaling pathway, lipid homeostasis, lipid metabolic process, mRNA transcription by RNA polymerase II, negative regulation of DNA-templated transcription, negative regulation of cholesterol storage, negative regulation of cold-induced thermogenesis, negative regulation of gene expression, negative regulation of inflammatory response, negative regulation of lipid transport, negative regulation of pinocytosis, negative regulation of proteolysis, negative regulation of response to endoplasmic reticulum stress, negative regulation of transcription by RNA polymerase II, phosphatidylcholine acyl-chain remodeling, positive regulation of DNA-templated transcription, positive regulation of cholesterol efflux, positive regulation of cholesterol transport, positive regulation of fatty acid biosynthetic process, positive regulation of gene expression, positive regulation of high-density lipoprotein particle assembly, positive regulation of lipid storage, positive regulation of miRNA transcription, positive regulation of pancreatic juice secretion, positive regulation of secretion of lysosomal enzymes, positive regulation of transcription by RNA polymerase II, positive regulation of triglyceride biosynthetic process, regulation of DNA-templated transcription, regulation of lipid storage, regulation of pancreatic juice secretion, regulation of secretion of lysosomal enzymes, regulation of transcription by RNA polymerase II, response to nutrient levels, retinoic acid receptor signaling pathway; MF: ATPase binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, apolipoprotein A-I receptor binding, chromatin DNA binding, metal ion binding, nuclear receptor activity, nuclear retinoid X receptor binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, cytoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Insulin resistance - Mus musculus (mouse), Metabolism of proteins, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Nuclear Receptor transcription pathway, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of intracellular receptors, Signal Transduction, Signaling by Nuclear Receptors, Transport of small molecules, VLDLR internalisation and degradation
UniProt: Q60644
Entrez ID: 22260
|
Does Knockout of Stt3b in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Stt3b
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Stt3b (STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, glycoprotein catabolic process, post-translational protein modification, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, response to unfolded protein; MF: dolichyl-diphosphooligosaccharide-protein glycotransferase activity, glycosyltransferase activity, metal ion binding, oligosaccharyl transferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex B, protein-containing complex
Pathways: Adaptive Immune System, Co-inhibition by PD-1, Immune System, N-Glycan biosynthesis - Mus musculus (mouse), PD-L1(CD274) glycosylation and translocation to plasma membrane, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q3TDQ1
Entrez ID: 68292
|
Does Knockout of Osgin1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Osgin1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Osgin1 (oxidative stress induced growth inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of cell growth, signal transduction; MF: growth factor activity, monooxygenase activity, oxidoreductase activity; CC: cellular_component, midbody
Pathways:
UniProt: Q8VC10
Entrez ID: 71839
|
Does Knockout of Phf5a in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Phf5a
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Phf5a (PHD finger protein 5A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, positive regulation of DNA-templated transcription, stem cell differentiation; MF: DNA binding, RNA binding, metal ion binding, protein binding, zinc ion binding; CC: U12-type spliceosomal complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, nuclear matrix, nuclear speck, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P83870
Entrez ID: 68479
|
Does Knockout of Clip3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Clip3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Clip3 (CAP-GLY domain containing linker protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, fat cell differentiation, membrane biogenesis, negative regulation of microtubule polymerization, peptidyl-L-cysteine S-palmitoylation, positive regulation of D-glucose transmembrane transport, positive regulation of apoptotic process, positive regulation of endocytosis, positive regulation of protein localization to plasma membrane, positive regulation of protein phosphorylation, protein transport along microtubule; MF: ganglioside binding, microtubule binding, microtubule plus-end binding, protein binding; CC: Golgi apparatus, Golgi stack, cell cortex, cytoplasm, early endosome membrane, membrane, membrane raft, microtubule plus-end, nucleus, plasma membrane, recycling endosome membrane, trans-Golgi network, trans-Golgi network membrane
Pathways: Death Receptor Signaling, Regulation of TNFR1 signaling, Signal Transduction, TNF signaling
UniProt: B9EHT4
Entrez ID: 76686
|
Does Knockout of H2-Eb1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
H2-Eb1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: H2-Eb1 (histocompatibility 2, class II antigen E beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response, immune system process, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of immune response; MF: CD4 receptor binding, MHC class II protein complex binding, MHC class II receptor activity, T cell receptor binding, peptide antigen binding, polysaccharide binding, protein binding; CC: MHC class II protein complex, cell surface, external side of plasma membrane, immunological synapse, late endosome membrane, lysosomal membrane, membrane, plasma membrane
Pathways: Allograft rejection - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Asthma - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Intestinal immune network for IgA production - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: A0A498U6I0, O78196, A0A494B9C8
Entrez ID: 14969
|
Does Knockout of Tmed7 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Tmed7
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Tmed7 (transmembrane p24 trafficking protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein transport; CC: COPI-coated vesicle membrane, COPII-coated ER to Golgi transport vesicle, ER to Golgi transport vesicle membrane, Golgi apparatus, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: E9Q7G1, D3YZZ5
Entrez ID: 66676
|
Does Knockout of Jaml in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Jaml
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Jaml (junction adhesion molecule like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, gamma-delta T cell activation, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, immune system process, monocyte extravasation, neutrophil chemotaxis, neutrophil extravasation, positive regulation of epithelial cell proliferation involved in wound healing; MF: cell adhesion molecule binding, integrin binding, protein homodimerization activity; CC: anchoring junction, bicellular tight junction, membrane, nucleoplasm, plasma membrane
Pathways: Adaptive Immune System, Cell surface interactions at the vascular wall, Hemostasis, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
UniProt: Q80UL9
Entrez ID: 270152
|
Does Knockout of Kifc1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Kifc1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Kifc1 (kinesin family member C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule-based movement, minus-end-directed vesicle transport along microtubule, mitotic metaphase chromosome alignment, mitotic spindle assembly, negative regulation of centrosome duplication, vesicle transport along microtubule; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, minus-end-directed microtubule motor activity, nucleotide binding, protein binding; CC: centrosome, cytoplasm, cytoskeleton, early endosome, endocytic vesicle, endosome, kinesin complex, microtubule, microtubule organizing center, mitotic spindle, nucleus, spindle, spindle pole centrosome
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9QWT9
Entrez ID: 100502766
|
Does Knockout of Smyd4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Smyd4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Smyd4 (SET and MYND domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heart development, methylation; MF: histone deacetylase binding, metal ion binding, methyltransferase activity, molecular_function, protein-lysine N-methyltransferase activity, transferase activity, zinc ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8BTK5
Entrez ID: 319822
|
Does Knockout of Ajuba in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Ajuba
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ajuba (ajuba LIM protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cytoskeleton organization, focal adhesion assembly, glycerophospholipid biosynthetic process, intracellular protein localization, lamellipodium assembly, miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated post-transcriptional gene silencing, negative regulation of hippo signaling, negative regulation of transcription by RNA polymerase II, positive regulation of biosynthetic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein-containing complex assembly, regulation of DNA-templated transcription, regulation of cell migration, regulation of cellular response to hypoxia, regulatory ncRNA-mediated gene silencing, response to hypoxia, wound healing, spreading of epidermal cells; MF: actin filament binding, alpha-catenin binding, chromatin binding, metal ion binding, protein binding, protein kinase activator activity, transcription corepressor activity; CC: Golgi apparatus, P-body, adherens junction, anchoring junction, cell-cell junction, centrosome, cytoplasm, cytoskeleton, cytosol, focal adhesion, lamellipodium, membrane, nucleoplasm, nucleus, plasma membrane, transcription regulator complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, G2/M Transition, Hippo signaling pathway - Mus musculus (mouse), Hippo signaling pathway - multiple species - Mus musculus (mouse), Mitotic G2-G2/M phases, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q91XC0
Entrez ID: 16475
|
Does Knockout of Polr3c in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Polr3c
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Polr3c (polymerase (RNA) III (DNA directed) polypeptide C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, defense response to virus, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta production; MF: DNA binding, nucleotidyltransferase activity, single-stranded DNA binding, transferase activity; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: Q9D483
Entrez ID: 74414
|
Does Knockout of Acot13 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Acot13
|
cell proliferation
|
Regulatory T cell
|
Gene: Acot13 (acyl-CoA thioesterase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, negative regulation of cold-induced thermogenesis, protein homotetramerization; MF: fatty acyl-CoA hydrolase activity, hydrolase activity; CC: cytoplasm, cytoskeleton, cytosol, mitochondrial matrix, mitochondrion, nucleus, spindle
Pathways: Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation
UniProt: Q9CQR4
Entrez ID: 66834
|
Does Knockout of Eif2s1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Eif2s1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: HRI-mediated signaling, PERK-mediated unfolded protein response, cellular response to UV, cellular response to amino acid starvation, cellular response to chemical stress, cellular response to heat, cellular response to oxidative stress, mitochondrial respirasome assembly, mitophagy, negative regulation of translational initiation in response to stress, positive regulation of type B pancreatic cell apoptotic process, regulation of translation, regulation of translation in response to endoplasmic reticulum stress, regulation of translational initiation in response to stress, response to endoplasmic reticulum stress, response to kainic acid, response to manganese-induced endoplasmic reticulum stress, stress granule assembly, translation, translational initiation; MF: RNA binding, nucleic acid binding, protein binding, ribosome binding, translation initiation factor activity; CC: cytoplasm, cytoplasmic stress granule, cytosol, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 2 complex, glial limiting end-foot, mitochondrion, nucleus, synapse, translation initiation ternary complex
Pathways: ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Cap-dependent Translation Initiation, Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Eukaryotic Translation Initiation, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), L13a-mediated translational silencing of Ceruloplasmin expression, Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, Non-alcoholic fatty liver disease - Mus musculus (mouse), PERK regulates gene expression, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Recycling of eIF2:GDP, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation, Transport of small molecules, Unfolded Protein Response (UPR)
UniProt: Q6ZWX6
Entrez ID: 13665
|
Does Knockout of Ilf3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ilf3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ilf3 (interleukin enhancer binding factor 3)
Type: protein-coding
Summary: The protein encoded by this gene contains two double-stranded RNA binding domains and functions in the post-transcriptional regulation of gene expression. It is a component of an RNA-protein complex that may be involved in mediating the export of messenger RNAs. Alternative splicing results in multiple transcript variants encoding distinct isoforms. These isoforms are grouped into two categories, NFAR-1 or NFAR-2, based on variation at the C-terminus. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: defense response to virus, negative regulation of DNA-templated transcription, negative regulation of translation, negative regulation of viral genome replication, positive regulation of DNA-templated transcription, protein phosphorylation, spliceosome-depend formation of circular RNA, symbiont entry into host cell; MF: DNA binding, RNA binding, double-stranded RNA binding, enzyme binding, mRNA 3'-UTR AU-rich region binding, single-stranded RNA binding, virus receptor activity; CC: cytoplasm, mitochondrion, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Adherens junctions interactions, Antiviral mechanism by IFN-stimulated genes, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cytokine Signaling in Immune system, Immune System, Interferon Signaling, PKR-mediated signaling, Regulation of CDH11 Expression and Function, Regulation of CDH11 gene transcription, Regulation of Expression and Function of Type II Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q9Z1X4
Entrez ID: 16201
|
Does Knockout of Scnn1a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Scnn1a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Scnn1a (sodium channel, nonvoltage-gated 1 alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to acidic pH, cellular response to aldosterone, cellular response to vasopressin, intracellular sodium ion homeostasis, monoatomic ion transmembrane transport, monoatomic ion transport, multicellular organismal-level water homeostasis, regulation of blood pressure, regulation of body fluid levels, sensory perception of salty taste, sensory perception of sour taste, sodium ion homeostasis, sodium ion import across plasma membrane, sodium ion transmembrane transport, sodium ion transport; MF: WW domain binding, actin binding, ligand-gated sodium channel activity, sodium channel activity, sodium ion transmembrane transporter activity; CC: acrosomal vesicle, apical plasma membrane, cell projection, ciliary membrane, cilium, cortical actin cytoskeleton, cytoplasm, cytoplasmic vesicle, cytosol, external side of plasma membrane, extracellular exosome, membrane, motile cilium, plasma membrane, sodium channel complex, sperm principal piece
Pathways: Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Ion channel transport, Sensory Perception, Sensory perception of salty taste, Sensory perception of taste, Stimuli-sensing channels, Taste transduction - Mus musculus (mouse), Transport of small molecules
UniProt: Q61180
Entrez ID: 20276
|
Does Knockout of Frrs1l in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Frrs1l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Frrs1l (ferric-chelate reductase 1 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of AMPA glutamate receptor clustering, regulation of glutamate receptor signaling pathway, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of synaptic transmission, glutamatergic; MF: dynein intermediate chain binding, protein-containing complex binding; CC: endoplasmic reticulum membrane, membrane, plasma membrane, postsynapse, synapse
Pathways:
UniProt: B1AXV0
Entrez ID: 230235
|
Does Knockout of Kntc1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Kntc1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Kntc1 (kinetochore associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, protein localization to kinetochore involved in kinetochore assembly; CC: RZZ complex, actin cytoskeleton, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, kinetochore microtubule, nucleus, plasma membrane, spindle, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8C3Y4
Entrez ID: 208628
|
Does Knockout of Elmod3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Elmod3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Elmod3 (ELMO/CED-12 domain containing 3)
Type: protein-coding
Summary: Acts upstream of or within several processes, including cilium assembly; inner ear receptor cell development; and sensory perception of sound. Is active in Golgi apparatus and cilium. Is expressed in cerebral cortex; cerebral cortex ventricular layer; cortical plate; hindbrain; and olfactory epithelium. Used to study autosomal recessive nonsyndromic deafness 88. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 81 and autosomal recessive nonsyndromic deafness 88. Orthologous to human ELMOD3 (ELMO domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: auditory receptor cell development, biological_process, cilium assembly, cytoskeleton organization, gene expression, intracellular protein localization, protein transport, sensory perception of sound, stereocilium maintenance; MF: GTPase activator activity, molecular_function; CC: Golgi apparatus, cell projection, cilium, cytoplasm, cytoskeleton, kinocilium, stereocilium
Pathways:
UniProt: Q91YP6
Entrez ID: 232089
|
Does Knockout of Apol6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Apol6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Apol6 (apolipoprotein L 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lipid transport, lipoprotein metabolic process; MF: lipid binding, molecular_function; CC: cellular_component, extracellular region, membrane
Pathways:
UniProt: B7ZC54, B7ZC55, Q9D6L7, Q3UN08, B7ZC57, D6RFC1, B7ZC56
Entrez ID: 71939
|
Does Knockout of Rapgef2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Rapgef2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rap protein signal transduction, Ras protein signal transduction, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, blood vessel development, brain-derived neurotrophic factor receptor signaling pathway, cell differentiation, cellular response to cAMP, cellular response to cGMP, cellular response to nerve growth factor stimulus, establishment of endothelial barrier, establishment of endothelial intestinal barrier, forebrain neuron development, negative regulation of cell population proliferation, negative regulation of dendrite morphogenesis, negative regulation of melanin biosynthetic process, nerve growth factor signaling pathway, nervous system development, neuron migration, neuron projection development, neuropeptide signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of GTPase activity, positive regulation of cAMP-dependent protein kinase activity, positive regulation of dendritic cell apoptotic process, positive regulation of microvillus assembly, positive regulation of neuron migration, positive regulation of neuron projection development, positive regulation of protein binding, positive regulation of protein kinase activity, positive regulation of vasculogenesis, regulation of cell junction assembly, regulation of modification of postsynaptic structure, regulation of neuron projection development, regulation of synaptic plasticity, signal transduction, small GTPase-mediated signal transduction, ventricular system development; MF: GTPase activator activity, PDZ domain binding, WW domain binding, beta-1 adrenergic receptor binding, cAMP binding, guanyl-nucleotide exchange factor activity, phosphatidic acid binding, protein kinase binding; CC: anchoring junction, apical plasma membrane, bicellular tight junction, cell-cell junction, cytoplasm, cytosol, endocytic vesicle, endosome, late endosome, membrane, neuron projection, neuronal cell body, perinuclear region of cytoplasm, plasma membrane, postsynapse, protein-containing complex, synapse
Pathways: MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Signal Transduction, Tight junction - Mus musculus (mouse)
UniProt: Q8CHG7
Entrez ID: 76089
|
Does Knockout of Chdh in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Chdh
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Chdh (choline dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: choline dehydrogenase activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Choline catabolism, Glycine, serine and threonine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives
UniProt: Q8BJ64
Entrez ID: 218865
|
Does Knockout of Crtam in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Crtam
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Crtam (cytotoxic and regulatory T cell molecule)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, cell adhesion, cell recognition, detection of stimulus, detection of tumor cell, establishment of T cell polarity, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, immune system process, lymphocyte migration into lymphoid organs, negative regulation of activated T cell proliferation, positive regulation of cytokine production, positive regulation of natural killer cell mediated cytotoxicity, positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, positive regulation of type II interferon production, regulation of CD8-positive, alpha-beta T cell activation, regulation of T cell activation, regulation of T cell differentiation; MF: identical protein binding, protein binding, signaling receptor binding; CC: immunological synapse, membrane, plasma membrane
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
UniProt: Q149L7
Entrez ID: 54698
|
Does Knockout of Col4a5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Col4a5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Col4a5 (collagen, type IV, alpha 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen-activated tyrosine kinase receptor signaling pathway, neuromuscular junction development; MF: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength; CC: basement membrane, collagen trimer, collagen type IV trimer, extracellular matrix, extracellular region, neuromuscular junction
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Crosslinking of collagen fibrils, Degradation of the extracellular matrix, Developmental Biology, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Fibronectin matrix formation, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Integrin cell surface interactions, Laminin interactions, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Small cell lung cancer - Mus musculus (mouse)
UniProt: F7CK55, Q63ZW6
Entrez ID: 12830
|
Does Knockout of Gnb1l in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Gnb1l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gnb1l (guanine nucleotide binding protein (G protein), beta polypeptide 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, social behavior; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9EQ15
Entrez ID: 13972
|
Does Knockout of Mtr in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Mtr
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mtr (5-methyltetrahydrofolate-homocysteine methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-methionine salvage, amino acid biosynthetic process, axon regeneration, cellular response to nitric oxide, cobalamin metabolic process, homocysteine metabolic process, methionine biosynthetic process, methionine metabolic process, methylation, pteridine-containing compound metabolic process, response to axon injury, tetrahydrofolate metabolic process; MF: amino acid binding, cobalamin binding, folic acid binding, metal ion binding, methionine synthase activity, methyltransferase activity, transferase activity, zinc ion binding; CC: cytoplasm, cytosol
Pathways: Biological oxidations, Cobalamin (Cbl) metabolism, Cobalamin (Cbl, vitamin B12) transport and metabolism, Cysteine and methionine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Methylation, One carbon pool by folate - Mus musculus (mouse), Phase II - Conjugation of compounds, RHO GTPase cycle, RHOH GTPase cycle, Selenocompound metabolism - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Sulfur amino acid metabolism, folate transformations I, folate transformations II (plants), methionine salvage II (mammalia), superpathway of methionine degradation
UniProt: A6H5Y3
Entrez ID: 238505
|
Does Knockout of Psma1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Psma1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Psma1 (proteasome subunit alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, negative regulation of inflammatory response to antigenic stimulus, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: lipopolysaccharide binding, protein binding; CC: centrosome, cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9R1P4
Entrez ID: 26440
|
Does Knockout of Nuf2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Nuf2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Nuf2 (NUF2, NDC80 kinetochore complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore organization, meiotic chromosome segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization; MF: microtubule binding, protein-containing complex binding; CC: Ndc80 complex, chromosome, chromosome, centromeric region, cytosol, kinetochore, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q99P69
Entrez ID: 66977
|
Does Knockout of Golga7b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Golga7b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Golga7b (golgin A7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: enzyme binding, protein binding; CC: Golgi apparatus, Golgi membrane, membrane, palmitoyltransferase complex, plasma membrane
Pathways:
UniProt: Q9D428
Entrez ID: 71146
|
Does Knockout of Tapbpl in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,280
|
Knockout
|
Tapbpl
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tapbpl (TAP binding protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, negative regulation of antigen processing and presentation of peptide antigen via MHC class I, peptide antigen assembly with MHC class I protein complex; MF: MHC class I protein complex binding, TAP complex binding; CC: Golgi apparatus, Golgi membrane, MHC class I peptide loading complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q8VD31
Entrez ID: 213233
|
Does Knockout of Urod in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Urod
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Urod (uroporphyrinogen decarboxylase)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the conversion of uroporphyrinogen-III to coproporphyrinogen-III, an intermediate step in heme biosynthesis. Homozygous knockout mice for this gene exhibit embryonic lethality. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: cell population proliferation, heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, heme metabolic process, porphyrin-containing compound biosynthetic process, porphyrin-containing compound catabolic process, porphyrin-containing compound metabolic process, protoporphyrinogen IX biosynthetic process, uroporphyrinogen III metabolic process; MF: carboxy-lyase activity, ferrous iron binding, lyase activity, uroporphyrinogen decarboxylase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Heme biosynthesis, Metabolism, Metabolism of porphyrins, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, heme biosynthesis from uroporphyrinogen-III I
UniProt: P70697
Entrez ID: 22275
|
Does Knockout of Psma4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Psma4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Psma4 (proteasome subunit alpha 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; CC: P-body, cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9R1P0
Entrez ID: 26441
|
Does Knockout of Bex4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Bex4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Bex4 (brain expressed X-linked 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromosome segregation, negative regulation of protein ubiquitination, negative regulation of tubulin deacetylation, regulation of cell migration, regulation of cell population proliferation, regulation of mitotic cell cycle; MF: alpha-tubulin binding, histone deacetylase binding, metal ion binding, molecular function inhibitor activity; CC: cytoplasm, cytoskeleton, cytosol, microtubule, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: Q9CWT2
Entrez ID: 406217
|
Does Knockout of Fblim1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Fblim1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fblim1 (filamin binding LIM protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion, regulation of cell shape, regulation of integrin activation; MF: filamin binding, metal ion binding, protein binding; CC: anchoring junction, cell junction, cell periphery, cytoplasm, cytoskeleton, fibrillar center, focal adhesion, stress fiber
Pathways: Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions
UniProt: Q71FD7
Entrez ID: 74202
|
Does Knockout of Smad9 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Smad9
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Smad9 (SMAD family member 9)
Type: protein-coding
Summary: This gene encodes a member of a family of proteins that act as downstream effectors of the bone morphogenetic protein (BMP) signaling pathway. The encoded protein is phosphorylated by BMP receptors, which stimulates its binding to SMAD4 and translocation into the nucleus, where it functions as a regulator of transcription. Activity of this protein is important for embryonic development. Mutation of this gene results in defects in pulmonary vasculature. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: BMP signaling pathway, Mullerian duct regression, SMAD protein signal transduction, anatomical structure morphogenesis, bone development, cartilage development, cell differentiation, cellular response to growth factor stimulus, hindbrain development, intracellular iron ion homeostasis, midbrain development, osteoblast differentiation, positive regulation of DNA-templated transcription, positive regulation of cell differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal system development, stem cell differentiation, transforming growth factor beta receptor signaling pathway, transforming growth factor beta receptor superfamily signaling pathway, ureteric bud development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, I-SMAD binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding; CC: cytoplasm, cytosol, heteromeric SMAD protein complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Signal Transduction, Signaling by BMP, Signaling by TGFB family members, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: Q9JIW5
Entrez ID: 55994
|
Does Knockout of Rdh1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Rdh1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rdh1 (retinol dehydrogenase 1 (all trans))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: androgen biosynthetic process, positive regulation of retinoic acid biosynthetic process, retinoic acid metabolic process, retinoid metabolic process, retinol metabolic process, steroid metabolic process; MF: all-trans-retinol dehydrogenase (NAD+) activity, androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, oxidoreductase activity, steroid dehydrogenase activity; CC: endoplasmic reticulum membrane, intracellular membrane-bounded organelle, organelle membrane
Pathways: RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, The canonical retinoid cycle in rods (twilight vision), Visual phototransduction
UniProt: Q8VIJ7, Q8CGV4
Entrez ID: 107605
|
Does Knockout of Msn in macrophage causally result in phagocytosis?
| 1
| 1,888
|
Knockout
|
Msn
|
phagocytosis
|
macrophage
|
Gene: Msn (moesin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell aggregation, T cell migration, T cell proliferation, establishment of endothelial barrier, establishment of epithelial cell apical/basal polarity, gland morphogenesis, immunological synapse formation, leukocyte cell-cell adhesion, leukocyte migration, membrane to membrane docking, positive regulation of early endosome to late endosome transport, positive regulation of gene expression, positive regulation of podosome assembly, positive regulation of protein catabolic process, positive regulation of protein localization to early endosome, regulation of cell shape, regulation of cell size, regulation of lymphocyte migration, regulation of organelle assembly; MF: actin binding, cell adhesion molecule binding, cytoskeletal protein binding, double-stranded RNA binding, enzyme binding, protein binding, protein kinase binding, signaling receptor binding; CC: T-tubule, adherens junction, apical part of cell, apical plasma membrane, basolateral plasma membrane, cell periphery, cell projection, cell surface, cell tip, cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, filopodium, filopodium membrane, focal adhesion, membrane, microvillus, microvillus membrane, myelin sheath, perinuclear region of cytoplasm, plasma membrane, pseudopodium, uropod
Pathways: Axon guidance, Developmental Biology, L1CAM interactions, Leukocyte transendothelial migration - Mus musculus (mouse), Measles - Mus musculus (mouse), Nervous system development, Proteoglycans in cancer - Mus musculus (mouse), Recycling pathway of L1, Regulation of actin cytoskeleton - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: P26041
Entrez ID: 17698
|
Does Knockout of Sbpl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Sbpl
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sbpl (spermine binding protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell migration; MF: carbohydrate binding, molecular_function; CC: apicolateral plasma membrane, cytoplasm, extracellular region, extracellular space, plasma membrane
Pathways:
UniProt: Q3TUY3, Q9CPP2
Entrez ID: 638345
|
Does Knockout of Lad1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Lad1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lad1 (ladinin)
Type: protein-coding
Summary: Predicted to enable structural molecule activity. Predicted to be located in actin cytoskeleton. Is expressed in several structures, including ganglia; incisor; sensory organ; submandibular gland primordium; and thymus primordium. Orthologous to human LAD1 (ladinin 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: actin cytoskeleton, basement membrane, extracellular region
Pathways:
UniProt: P57016
Entrez ID: 16763
|
Does Knockout of Glyr1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Glyr1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Glyr1 (glyoxylate reductase 1 homolog (Arabidopsis))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transcription elongation-coupled chromatin remodeling, transcription initiation-coupled chromatin remodeling; MF: DNA binding, NAD binding, NADP binding, chromatin binding, chromatin-protein adaptor activity, histone binding, nucleosome binding; CC: chromatin, chromosome, cytosol, nucleoplasm, nucleosome, nucleus
Pathways:
UniProt: Q922P9
Entrez ID: 74022
|
Does Knockout of Rasl2-9 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Rasl2-9
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rasl2-9 (RAS-like, family 2, locus 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GTP metabolic process, glycolytic process, mitotic sister chromatid segregation, nucleocytoplasmic transport, positive regulation of protein import into nucleus, protein export from nucleus, protein import into nucleus, protein localization to nucleolus, protein transport, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus, ribosomal subunit export from nucleus, snRNA import into nucleus; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, magnesium ion binding, nucleotide binding, pre-miRNA binding, protein heterodimerization activity; CC: RNA nuclear export complex, centriole, chromatin, cytoplasm, midbody, nuclear envelope, nucleolus, nucleoplasm, nucleus, protein-containing complex, recycling endosome
Pathways: Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Nucleocytoplasmic transport - Mus musculus (mouse), Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q61820
Entrez ID: 19428
|
Does Knockout of Smarcb1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,551
|
Knockout
|
Smarcb1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Smarcb1 (SWI/SNF related BAF chromatin remodeling complex subunit B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, blastocyst development, blastocyst hatching, chromatin organization, chromatin remodeling, hepatocyte differentiation, host-mediated activation of viral transcription, negative regulation of cell population proliferation, nervous system development, nucleosome disassembly, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of double-strand break repair, positive regulation of glucose mediated signaling pathway, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, single stranded viral RNA replication via double stranded DNA intermediate, transcription initiation-coupled chromatin remodeling; MF: DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, Tat protein binding, identical protein binding, p53 binding, protein binding, transcription coactivator activity; CC: RSC-type complex, SWI/SNF complex, XY body, bBAF complex, brahma complex, chromatin, fibrillar center, germ cell nucleus, kinetochore, nBAF complex, npBAF complex, nuclear chromosome, nuclear matrix, nucleolus, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: Q9Z0H3
Entrez ID: 20587
|
Does Knockout of Sncb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Sncb
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Sncb (synuclein, beta)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity and tubulin binding activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; dopamine metabolic process; and negative regulation of neuron apoptotic process. Located in synapse. Is expressed in central nervous system; peripheral nervous system; retina; stomach; and testis. Human ortholog(s) of this gene implicated in Lewy body dementia and Parkinson's disease. Orthologous to human SNCB (synuclein beta). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chemical synaptic transmission, dopamine metabolic process, negative regulation of neuron apoptotic process, neuron apoptotic process, synapse organization, synaptic vesicle endocytosis; MF: alpha-tubulin binding, beta-tubulin binding, calcium ion binding, cuprous ion binding, transition metal ion binding; CC: axon terminus, cytoplasm, growth cone, inclusion body, mitochondrion, neuronal cell body, presynaptic cytosol, synapse, terminal bouton
Pathways:
UniProt: Q91ZZ3
Entrez ID: 104069
|
Does Knockout of H2-DMb2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
H2-DMb2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: H2-DMb2 (histocompatibility 2, class II, locus Mb2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MHC class II protein complex assembly, adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response, immune system process, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, positive regulation of T cell proliferation, positive regulation of immune response, protein folding; MF: MHC class II protein complex binding, peptide antigen binding, protein binding; CC: MHC class II protein complex, endosome, endosome membrane, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, multivesicular body
Pathways: Adaptive Immune System, Allograft rejection - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Asthma - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Intestinal immune network for IgA production - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), MHC class II antigen presentation, Phagosome - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: F7AD18, Q31099
Entrez ID: 15000
|
Does Knockout of Mrps9 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mrps9
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrps9 (mitochondrial ribosomal protein S9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, structural constituent of ribosome; CC: intracellular organelle lumen, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, nucleolus, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D7N3
Entrez ID: 69527
|
Does Knockout of Abraxas1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Abraxas1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Abraxas1 (BRCA1 A complex subunit)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; nuclear chromosome segregation; and positive regulation of DNA repair. Predicted to be located in nuclear body. Predicted to be part of BRCA1-A complex. Predicted to be active in nucleus. Orthologous to human ABRAXAS1 (abraxas 1, BRCA1 A complex subunit). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, attachment of spindle microtubules to kinetochore, chromatin organization, double-strand break repair, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, mitotic spindle assembly, positive regulation of DNA repair, regulation of DNA repair, response to ionizing radiation; MF: microtubule binding, polyubiquitin modification-dependent protein binding; CC: BRCA1-A complex, nuclear body, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, G2/M DNA damage checkpoint, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Processing of DNA double-strand break ends, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q8BPZ8
Entrez ID: 70681
|
Does Knockout of Suz12 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Suz12
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Suz12 (SUZ12 polycomb repressive complex 2 subunit)
Type: protein-coding
Summary: This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: chromatin organization, facultative heterochromatin formation, negative regulation of cell differentiation, negative regulation of chemokine production, negative regulation of epithelial cell proliferation, negative regulation of transcription by RNA polymerase II, oligodendrocyte differentiation, positive regulation of cell population proliferation, random inactivation of X chromosome, response to retinoic acid, spinal cord development; MF: RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, enzyme activator activity, histone H3K9me2/3 reader activity, histone methyltransferase activity, lncRNA binding, metal ion binding, promoter-specific chromatin binding, protein binding, sequence-specific DNA binding, transcription corepressor binding, zinc ion binding; CC: ESC/E(Z) complex, RSC-type complex, chromatin silencing complex, chromosome, nuclear body, nucleolus, nucleoplasm, nucleus, protein-DNA complex, ribonucleoprotein complex, sex chromatin
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Co-inhibition by PD-1, Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Metabolism of proteins, Negative Regulation of CDH1 Gene Transcription, Oxidative Stress Induced Senescence, PKMTs methylate histone lysines, PRC2 methylates histones and DNA, Post-translational protein modification, RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of chromatin organization proteins, Transcriptional Regulation by E2F6
UniProt: Q80U70
Entrez ID: 52615
|
Does Knockout of Dis3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Dis3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Dis3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CUT catabolic process, RNA catabolic process, RNA processing, nuclear mRNA surveillance of mRNA 3'-end processing, nuclear-transcribed mRNA catabolic process, rRNA catabolic process, rRNA processing; MF: 3'-5'-RNA exonuclease activity, RNA binding, RNA nuclease activity, endonuclease activity, exonuclease activity, guanyl-nucleotide exchange factor activity, hydrolase activity, nuclease activity; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CSH3
Entrez ID: 72662
|
Does Knockout of Arpc2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Arpc2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Arpc2 (actin related protein 2/3 complex, subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin filament polymerization, cellular response to epidermal growth factor stimulus, cellular response to platelet-derived growth factor stimulus, cellular response to rapamycin, intracellular signal transduction, positive regulation of actin filament polymerization, positive regulation of barbed-end actin filament capping, positive regulation of filopodium assembly, positive regulation of lamellipodium assembly, positive regulation of podosome assembly, positive regulation of protein targeting to membrane, positive regulation of protein-containing complex assembly, positive regulation of smooth muscle cell migration, positive regulation of substrate adhesion-dependent cell spreading, regulation of actin cytoskeleton organization, regulation of actin filament polymerization; MF: ATPase binding, actin binding, actin filament binding, glutamate receptor binding, protein binding, protein-containing complex binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, Schaffer collateral - CA1 synapse, actin cytoskeleton, actin filament branch point, apical dendrite, axon terminus, cell leading edge, cell projection, cell surface, concave side of sperm head, cytoplasm, cytoskeleton, dendritic shaft, dendritic spine, endosome, filamentous actin, focal adhesion, glutamatergic synapse, growth cone, lamellipodium, muscle cell projection membrane, neuron projection, nucleoplasm, nucleus, perikaryon, peripheral region of growth cone, plasma membrane, podosome core, podosome ring, postsynapse, presynapse, ruffle membrane, secretory granule, site of double-strand break, synapse, synaptic vesicle membrane, ventral surface of cell
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Membrane Trafficking, Nervous system development, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: Q9CVB6
Entrez ID: 76709
|
Does Knockout of Adi1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Adi1
|
phagocytosis
|
macrophage
|
Gene: Adi1 (acireductone dioxygenase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-methionine salvage from methylthioadenosine, amino acid biosynthetic process, methionine biosynthetic process, methionine metabolic process; MF: acireductone dioxygenase (Ni2+-requiring) activity, acireductone dioxygenase [iron(II)-requiring] activity, dioxygenase activity, iron ion binding, metal ion binding, nickel cation binding, oxidoreductase activity; CC: cytoplasm, membrane, nucleus, plasma membrane
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Methionine salvage pathway, Sulfur amino acid metabolism, methylthiopropionate biosynthesis
UniProt: Q99JT9
Entrez ID: 104923
|
Does Knockout of Cct4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Cct4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cct4 (chaperonin containing TCP1 subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, scaRNA localization to Cajal body; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, cell projection, centrosome, chaperonin-containing T-complex, cilium, cytoplasm, cytoskeleton, cytosol, melanosome, microtubule, nucleoplasm, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: P80315
Entrez ID: 12464
|
Does Knockout of Ddx11 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Ddx11
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ddx11 (DEAD/H box helicase 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, cellular response to bleomycin, cellular response to cisplatin, cellular response to hydroxyurea, establishment of sister chromatid cohesion, negative regulation of protein binding, nucleobase-containing compound metabolic process, nucleolar chromatin organization, positive regulation of chromatin binding, positive regulation of double-strand break repair, positive regulation of sister chromatid cohesion, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, replication fork processing, sister chromatid cohesion; MF: 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent activity, acting on RNA, DNA binding, DNA helicase activity, DNA replication origin binding, G-quadruplex DNA binding, RNA binding, catalytic activity, acting on a nucleic acid, chromatin binding, double-stranded DNA binding, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, iron-sulfur cluster binding, isomerase activity, metal ion binding, nucleic acid binding, nucleotide binding, single-stranded DNA binding, single-stranded RNA binding, triplex DNA binding; CC: centrosome, chromatin, cytoplasm, cytoskeleton, extracellular exosome, midbody, mitotic cohesin complex, nucleolus, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: Q6AXC6
Entrez ID: 320209
|
Does Knockout of Krtap4-6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Krtap4-6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Krtap4-6 (keratin associated protein 4-6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q3V4B7
Entrez ID: 68768
|
Does Knockout of Pard6g in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Pard6g
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Pard6g (par-6 family cell polarity regulator gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome cycle, establishment or maintenance of cell polarity, regulation of cellular localization; CC: anchoring junction, apical plasma membrane, bicellular tight junction, cell cortex, cytoplasm, membrane, nucleus, plasma membrane, protein-containing complex
Pathways: Axon guidance - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Endocytosis - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Tight junction interactions
UniProt: Q9JK84
Entrez ID: 93737
|
Does Knockout of Gabra6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Gabra6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gabra6 (gamma-aminobutyric acid type A receptor subunit alpha 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, chloride transport, gamma-aminobutyric acid signaling pathway, inhibitory synapse assembly, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of postsynaptic membrane potential, synaptic transmission, GABAergic; MF: GABA-A receptor activity, GABA-gated chloride ion channel activity, benzodiazepine receptor activity, chloride channel activity, diazepam binding, extracellular ligand-gated monoatomic ion channel activity, heterocyclic compound binding, inhibitory extracellular ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, protein-containing complex binding, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: GABA-A receptor complex, GABA-ergic synapse, cerebellar Golgi cell to granule cell synapse, chloride channel complex, dendrite, dendrite membrane, hippocampal mossy fiber to CA3 synapse, membrane, neuronal cell body membrane, plasma membrane, postsynapse, postsynaptic membrane, postsynaptic specialization membrane, presynaptic membrane, receptor complex, synapse
Pathways: GABA receptor activation, GABAergic synapse - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Taste transduction - Mus musculus (mouse), Transmission across Chemical Synapses
UniProt: P16305
Entrez ID: 14399
|
Does Knockout of Lyzl6 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Lyzl6
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Lyzl6 (lysozyme-like 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to bacterium, fertilization, fusion of sperm to egg plasma membrane involved in single fertilization, killing of cells of another organism, single fertilization; MF: catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, lysozyme activity; CC: acrosomal vesicle, cell projection, cell surface, cilium, extracellular region, motile cilium, sperm flagellum, sperm midpiece, sperm plasma membrane
Pathways:
UniProt: Q9DA11
Entrez ID: 69444
|
Does Knockout of Tbc1d16 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Tbc1d16
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tbc1d16 (TBC1 domain family, member 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of receptor recycling; MF: GTPase activator activity; CC: cytosol, early endosome
Pathways: Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: A2ABG4, Q6PFC0, Q8BXD8, A2AFK9
Entrez ID: 207592
|
Does Knockout of Cd200r1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Cd200r1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cd200r1 (CD200 receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heterotypic cell-cell adhesion, negative regulation of T cell migration, negative regulation of interleukin-6 production, negative regulation of macrophage migration, negative regulation of neuroinflammatory response, regulation of neuroinflammatory response; MF: protein binding, protein binding involved in heterotypic cell-cell adhesion, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane, receptor complex
Pathways: Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse)
UniProt: Q9ES57
Entrez ID: 57781
|
Does Knockout of Lmod1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Lmod1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Lmod1 (leiomodin 1 (smooth muscle))
Type: protein-coding
Summary: Predicted to enable tropomyosin binding activity. Predicted to be involved in actin cytoskeleton organization; muscle contraction; and positive regulation of actin filament polymerization. Predicted to be located in actin filament; cytosol; and sarcomere. Predicted to be active in striated muscle thin filament. Is expressed in several structures, including aorta; genitourinary system; gut; inner ear; and musculature. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human LMOD1 (leiomodin 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: actin filament organization, actin nucleation, muscle contraction, myofibril assembly, pointed-end actin filament capping, positive regulation of actin filament polymerization; MF: actin binding, tropomyosin binding; CC: actin filament, cytoplasm, cytoskeleton, cytosol, myofibril, sarcomere, striated muscle thin filament
Pathways: Muscle contraction, Smooth Muscle Contraction
UniProt: Q8BVA4
Entrez ID: 93689
|
Does Knockout of Gng2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Gng2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gng2 (guanine nucleotide binding protein (G protein), gamma 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, fibroblast proliferation, signal transduction; MF: G-protein beta-subunit binding, GTPase activity; CC: heterotrimeric G-protein complex, membrane, plasma membrane, synapse
Pathways: ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of G protein gated Potassium channels, Activation of GABAB receptors, Activation of kainate receptors upon glutamate binding, Adrenaline,noradrenaline inhibits insulin secretion, Alcoholism - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Aquaporin-mediated transport, Beta-catenin independent WNT signaling, Ca2+ pathway, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chaperonin-mediated protein folding, Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Class B/2 (Secretin family receptors), Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Dopaminergic synapse - Mus musculus (mouse), ESR-mediated signaling, Extra-nuclear estrogen signaling, G alpha (12/13) signalling events, G alpha (i) signalling events, G alpha (q) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G beta:gamma signalling through BTK, G beta:gamma signalling through CDC42, G beta:gamma signalling through PI3Kgamma, G beta:gamma signalling through PLC beta, G protein gated Potassium channels, G-protein activation, G-protein beta:gamma signalling, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Mus musculus (mouse), GPCR downstream signalling, GPCR ligand binding, GPER1 signaling, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Glutamatergic synapse - Mus musculus (mouse), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Integration of energy metabolism, Inwardly rectifying K+ channels, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Metabolism, Metabolism of proteins, Morphine addiction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet homeostasis, Potassium Channels, Presynaptic function of Kainate receptors, Prostacyclin signalling through prostacyclin receptor, Protein folding, Ras signaling pathway - Mus musculus (mouse), Regulation of insulin secretion, Relaxin signaling pathway - Mus musculus (mouse), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by WNT, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, Transmission across Chemical Synapses, Transport of small molecules, Vasopressin regulates renal water homeostasis via Aquaporins
UniProt: P63213
Entrez ID: 14702
|
Does Knockout of Ddx52 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ddx52
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ddx52 (DExD box helicase 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8K301
Entrez ID: 78394
|
Does Knockout of Iba57 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Iba57
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Iba57 (IBA57 homolog, iron-sulfur cluster assembly)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heme biosynthetic process, iron-sulfur cluster assembly; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q8CAK1
Entrez ID: 216792
|
Does Knockout of Kctd20 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Kctd20
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Kctd20 (potassium channel tetramerisation domain containing 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, protein binding; CC: cytoplasm
Pathways:
UniProt: Q8CDD8
Entrez ID: 66989
|
Does Knockout of Mrpl34 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mrpl34
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrpl34 (mitochondrial ribosomal protein L34)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL34 (mitochondrial ribosomal protein L34). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q99N91
Entrez ID: 94065
|
Does Knockout of Sptb in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Sptb
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sptb (spectrin beta, erythrocytic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament capping, hemopoiesis, modification of postsynaptic actin cytoskeleton, plasma membrane organization, porphyrin-containing compound biosynthetic process; MF: actin binding, actin filament binding, ankyrin binding, protein binding, structural constituent of cytoskeleton; CC: cell cortex, cell junction, cell projection, cell surface, cortical actin cytoskeleton, cortical cytoskeleton, cytoplasm, cytoskeleton, cytosol, glutamatergic synapse, membrane, plasma membrane, postsynapse, protein-containing complex, spectrin, spectrin-associated cytoskeleton
Pathways:
UniProt: E9Q397, Q3UGX2
Entrez ID: 20741
|
Does Knockout of Rpl13a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Rpl13a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rpl13a (ribosomal protein L13A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to type II interferon, cytoplasmic translation, homeostatic process, lung morphogenesis, macrophage chemotaxis, negative regulation of formation of translation preinitiation complex, negative regulation of translation, positive regulation of natural killer cell proliferation, regulation of translation, response to lipopolysaccharide, translation, translation at postsynapse, translation at presynapse; MF: mRNA binding, structural constituent of ribosome; CC: GAIT complex, cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P19253
Entrez ID: 22121
|
Does Knockout of Plekho2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Plekho2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Plekho2 (pleckstrin homology domain containing, family O member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: macrophage apoptotic process
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q8K124
Entrez ID: 102595
|
Does Knockout of Exoc3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Exoc3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Exoc3 (exocyst complex component 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocyst localization, exocytosis, membrane fission, mitotic cytokinesis, protein transport, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; CC: Golgi apparatus, cell projection, cytoplasm, exocyst, growth cone, membrane, midbody, neuron projection, perinuclear region of cytoplasm, presynaptic membrane, secretory granule membrane
Pathways: Cargo trafficking to the periciliary membrane, Cilium Assembly, Insulin processing, Metabolism of proteins, Organelle biogenesis and maintenance, Peptide hormone metabolism, VxPx cargo-targeting to cilium
UniProt: Q6KAR6
Entrez ID: 211446
|
Does Knockout of 4931400O07Rik in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
4931400O07Rik
|
cell proliferation
|
Melanoma Cell Line
|
Gene: 4931400O07Rik (RIKEN cDNA 4931400O07 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 70936
|
Does Knockout of Vmn2r121 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Vmn2r121
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Vmn2r121 (vomeronasal 2, receptor 121)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2W7Z9, A2BE32, A0A3B2WAV1
Entrez ID: 100038941
|
Does Knockout of Maml1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Maml1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Maml1 (mastermind like transcriptional coactivator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, atrioventricular node cell development, myoblast differentiation, positive regulation of muscle cell differentiation, positive regulation of myotube differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of Notch receptor target; MF: peptide antigen binding, protein kinase binding, transcription coactivator activity; CC: MAML1-RBP-Jkappa- ICN1 complex, nuclear speck, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Human papillomavirus infection - Mus musculus (mouse), NOTCH1 Intracellular Domain Regulates Transcription, Notch signaling pathway - Mus musculus (mouse), Notch-HLH transcription pathway, RNA Polymerase II Transcription, RUNX3 regulates NOTCH signaling, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Th1 and Th2 cell differentiation - Mus musculus (mouse), Transcriptional regulation by RUNX3
UniProt: Q6T264
Entrez ID: 103806
|
Does Knockout of Gabarap in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gabarap
|
phagocytosis
|
macrophage
|
Gene: Gabarap (gamma-aminobutyric acid receptor associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, autophagosome assembly, autophagosome maturation, autophagy, cellular response to nitrogen starvation, extrinsic apoptotic signaling pathway via death domain receptors, microtubule cytoskeleton organization, mitophagy, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K48-linked ubiquitination, protein transport, regulation of Rac protein signal transduction, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; MF: GABA receptor binding, beta-tubulin binding, microtubule binding, phosphatidylethanolamine binding, protein binding, ubiquitin protein ligase binding; CC: GABA-ergic synapse, Golgi apparatus, Golgi membrane, actin cytoskeleton, autophagosome, autophagosome membrane, axoneme, cell body, cytoplasm, cytoplasmic vesicle, cytoskeleton, endomembrane system, lysosome, membrane, microtubule, microtubule associated complex, perinuclear region of cytoplasm, plasma membrane, postsynaptic specialization, intracellular component, smooth endoplasmic reticulum, sperm midpiece
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), GABAergic synapse - Mus musculus (mouse), Macroautophagy, Membrane Trafficking, Mitophagy - animal - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q9DCD6
Entrez ID: 56486
|
Does Knockout of Bcl2l15 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Bcl2l15
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Bcl2l15 (BCLl2-like 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of apoptotic process; CC: cytosol, nucleus
Pathways:
UniProt: Q08ED0
Entrez ID: 229672
|
Does Knockout of Cbfa2t3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Cbfa2t3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cbfa2t3 (CBFA2/RUNX1 translocation partner 3)
Type: protein-coding
Summary: Enables chromatin binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; mesenchyme derived from splanchnopleure; retina; and spleen. Orthologous to human CBFA2T3 (CBFA2/RUNX1 partner transcriptional co-repressor 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription, cell differentiation, granulocyte differentiation, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of glycolytic process, negative regulation of transcription by RNA polymerase II, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of DNA-templated transcription, regulation of aerobic respiration, response to hypoxia; MF: chromatin binding, metal ion binding, protein binding, transcription corepressor activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, membrane, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: O54972
Entrez ID: 12398
|
Does Knockout of Pcnx3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Pcnx3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pcnx3 (pecanex homolog 3)
Type: protein-coding
Summary: Predicted to be located in membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system. Orthologous to human PCNX3 (pecanex 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8VI59
Entrez ID: 104401
|
Does Knockout of Csnk1a1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Csnk1a1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Csnk1a1 (casein kinase 1, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, NLRP3 inflammasome complex assembly, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, TORC1 signaling, Wnt signaling pathway, autophagosome assembly, cell division, cell morphogenesis, cellular response to nutrient, cellular response to nutrient levels, intermediate filament cytoskeleton organization, negative regulation of NLRP3 inflammasome complex assembly, negative regulation of TORC1 signaling, negative regulation of autophagy, negative regulation of canonical Wnt signaling pathway, negative regulation of signal transduction, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of Rho protein signal transduction, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein phosphorylation, signal transduction; MF: ATP binding, kinase activity, magnesium ion binding, nucleotide binding, peptide binding, phosphoprotein binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: beta-catenin destruction complex, cell projection, centrosome, chromosome, chromosome, centromeric region, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, keratin filament, kinetochore, mRNA cleavage and polyadenylation specificity factor complex, nuclear speck, nucleus, ribonucleoprotein complex, spindle
Pathways: Activation of SMO, Alzheimer disease - Mus musculus (mouse), Beta-catenin phosphorylation cascade, Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Degradation of beta-catenin by the destruction complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, G1/S DNA Damage Checkpoints, GLI3 is processed to GLI3R by the proteasome, Gastric cancer - Mus musculus (mouse), Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog signaling pathway - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Signal Transduction, Signaling by Hedgehog, Signaling by WNT, TCF dependent signaling in response to WNT, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Wnt signaling pathway - Mus musculus (mouse), p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q8BK63
Entrez ID: 93687
|
Does Knockout of Gkap1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Gkap1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Gkap1 (G kinase anchoring protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger, cGMP-mediated signaling, positive regulation of insulin receptor signaling pathway, signal transduction; MF: identical protein binding, protein binding; CC: Golgi apparatus
Pathways:
UniProt: Q9JMB0
Entrez ID: 56278
|
Does Knockout of Ephx2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ephx2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ephx2 (epoxide hydrolase 2, cytoplasmic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol homeostasis, dephosphorylation, epoxide metabolic process, linoleic acid metabolic process, lipid metabolic process, phospholipid dephosphorylation, positive regulation of blood pressure, positive regulation of gene expression, prostaglandin production involved in inflammatory response, regulation of cholesterol metabolic process, response to toxic substance, stilbene catabolic process; MF: 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity, catalytic activity, epoxide hydrolase activity, hydrolase activity, lipid phosphatase activity, lysophosphatidic acid phosphatase activity, magnesium ion binding, metal ion binding, phosphatase activity, protein homodimerization activity, toxic substance binding; CC: cytoplasm, cytosol, peroxisome
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biosynthesis of DHA-derived SPMs, Biosynthesis of maresins, Biosynthesis of specialized proresolving mediators (SPMs), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Protein localization, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
UniProt: P34914
Entrez ID: 13850
|
Does Knockout of Pigl in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Pigl
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pigl (phosphatidylinositol glycan anchor biosynthesis, class L)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, lipid metabolic process; MF: N-acetylglucosaminylphosphatidylinositol deacetylase activity, hydrolase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Synthesis of glycosylphosphatidylinositol (GPI)
UniProt: Q5SX19
Entrez ID: 327942
|
Does Knockout of Dlgap2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Dlgap2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dlgap2 (DLG associated protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: modulation of chemical synaptic transmission, signaling; MF: molecular adaptor activity, protein domain specific binding; CC: dendrite, dendritic spine, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic density, intracellular component, postsynaptic specialization, synapse
Pathways: Neurexins and neuroligins, Neuronal System, Protein-protein interactions at synapses
UniProt: Q8BJ42
Entrez ID: 244310
|
Does Knockout of Sp3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Sp3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sp3 (trans-acting transcription factor 3)
Type: protein-coding
Summary: This gene product belongs to a family of Sp1 related transcription factors, which regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses transcription of numerous genes. Alternative splicing results in transcript variants encoding different isoforms, and one variant initiates translation from a non-AUG (AUA) codon. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell differentiation, T cell differentiation, definitive hemopoiesis, embryonic camera-type eye morphogenesis, embryonic placenta development, embryonic process involved in female pregnancy, embryonic skeletal system development, enucleate erythrocyte differentiation, erythrocyte differentiation, granulocyte differentiation, in utero embryonic development, liver development, lung development, megakaryocyte differentiation, monocyte differentiation, myeloid progenitor cell differentiation, natural killer cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, ossification, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, trophectodermal cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: PML body, cytosol, nucleoplasm, nucleus, protein-DNA complex, transcription repressor complex
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription factors
UniProt: O70494
Entrez ID: 20687
|
Does Knockout of C1qtnf5 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
C1qtnf5
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: C1qtnf5 (C1q and tumor necrosis factor related protein 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the C1q/tumor necrosis factor superfamily. This family member is a secretory protein that functions in eye development. Mutations in this gene are thought to underlie the pathophysiology of late-onset retinal degeneration (L-ORD) and early-onset long anterior zonules (LAZ). Bicistronic transcripts composed of the coding sequences for this gene (C1qtnf5) and the membrane-type frizzled-related protein gene (Mfrp) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: inner ear development, protein secretion; MF: identical protein binding, protein binding; CC: apical plasma membrane, bicellular tight junction, cell projection, collagen trimer, extracellular region, extracellular space, lateral plasma membrane, membrane, plasma membrane, protein-containing complex, transport vesicle
Pathways:
UniProt: Q8K480, Q8K479
Entrez ID: 235312
|
Does Knockout of Tbx22 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Tbx22
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Tbx22 (T-box 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell fate specification, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription repressor complex, chromatin, nucleus
Pathways:
UniProt: Q8K402
Entrez ID: 245572
|
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