prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Thra in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Thra
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Thra (thyroid hormone receptor alpha)
Type: protein-coding
Summary: The protein encoded by this gene is one of several nuclear hormone receptors that bind thyroid hormones such as triiodothyronine and thyroxine with high affinity. The encoded protein is a transcription factor that can activate or repress transcription. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: animal organ morphogenesis, cartilage condensation, cell differentiation, erythrocyte differentiation, female courtship behavior, hormone-mediated signaling pathway, learning or memory, mRNA transcription by RNA polymerase II, negative regulation of DNA-templated transcription, negative regulation of DNA-templated transcription initiation, negative regulation of RNA polymerase II transcription preinitiation complex assembly, negative regulation of transcription by RNA polymerase II, ossification, positive regulation of canonical Wnt signaling pathway, positive regulation of cold-induced thermogenesis, positive regulation of female receptivity, positive regulation of myotube differentiation, positive regulation of thyroid hormone receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of female receptivity, regulation of heart contraction, regulation of lipid catabolic process, regulation of myeloid cell apoptotic process, regulation of thyroid hormone receptor signaling pathway, regulation of transcription by RNA polymerase II, response to cold, retinoic acid receptor signaling pathway, thyroid gland development, thyroid hormone receptor signaling pathway, transcription by RNA polymerase II, type I pneumocyte differentiation; MF: DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, TBP-class protein binding, chromatin DNA binding, general transcription initiation factor binding, intronic transcription regulatory region sequence-specific DNA binding, metal ion binding, nuclear receptor activity, protein binding, protein domain specific binding, protein homodimerization activity, protein sequestering activity, protein-containing complex binding, sequence-specific DNA binding, single-stranded RNA binding, steroid receptor RNA activator RNA binding, thyroid hormone binding, transcription cis-regulatory region binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, cytoplasm, cytosol, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nuclear Receptor transcription pathway, Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of intracellular receptors, Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: P63058
Entrez ID: 21833
|
Does Knockout of Gstm5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Gstm5
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gstm5 (glutathione S-transferase, mu 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular detoxification of nitrogen compound, glutathione metabolic process, nitrobenzene metabolic process, response to estrogen, xenobiotic catabolic process; MF: enzyme binding, glutathione binding, glutathione transferase activity, identical protein binding, protein binding, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol, sperm fibrous sheath
Pathways: Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: P48774
Entrez ID: 14866
|
Does Knockout of Cul9 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Cul9
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cul9 (cullin 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, protein ubiquitination, regulation of mitotic nuclear division, ubiquitin-dependent protein catabolic process; MF: ATP binding, metal ion binding, nucleotide binding, transferase activity, ubiquitin protein ligase binding, zinc ion binding; CC: cullin-RING ubiquitin ligase complex, cytoplasm, cytosol
Pathways:
UniProt: Q80TT8
Entrez ID: 78309
|
Does Knockout of Dcun1d5 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Dcun1d5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dcun1d5 (defective in cullin neddylation 1 domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, positive regulation of protein neddylation, protein neddylation, regulation of cell growth, regulation of protein neddylation; MF: cullin family protein binding, ubiquitin conjugating enzyme binding, ubiquitin-like protein binding; CC: cytoplasm, cytoskeleton, nucleus, spindle, ubiquitin ligase complex
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9CXV9
Entrez ID: 76863
|
Does Knockout of Hdac5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Hdac5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hdac5 (histone deacetylase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell differentiation, cellular response to fluid shear stress, chromatin organization, epigenetic regulation of gene expression, heart development, inflammatory response, multicellular organismal response to stress, negative regulation of DNA-templated transcription, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of gene expression, negative regulation of myotube differentiation, negative regulation of osteoblast differentiation, negative regulation of striated muscle tissue development, negative regulation of transcription by RNA polymerase II, nervous system development, osteoblast development, positive regulation of neural precursor cell proliferation, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of myotube differentiation, regulation of skeletal muscle fiber development, regulation of skeletal muscle fiber differentiation, renal tubule morphogenesis, response to cocaine, response to xenobiotic stimulus; MF: DNA-binding transcription activator activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, histone deacetylase activity, histone deacetylase activity, hydrolytic mechanism, histone deacetylase binding, hydrolase activity, identical protein binding, metal ion binding, protein binding, protein kinase C binding, protein kinase binding, protein lysine deacetylase activity, transcription cis-regulatory region binding, transcription corepressor activity, transcription corepressor binding; CC: Golgi apparatus, RNA polymerase II transcription repressor complex, axonal growth cone, chromatin, cytoplasm, cytosol, histone deacetylase complex, nuclear body, nuclear speck, nucleus, protein-containing complex
Pathways: Alcoholism - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q6P9T4, Q3UJF1, B7ZDF5, B7ZDF7, A2AWS5, D6RH93, B7ZDF3, B7ZDF6, B7ZDF4
Entrez ID: 15184
|
Does Knockout of Bbox1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Bbox1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Bbox1 (gamma-butyrobetaine hydroxylase 1)
Type: protein-coding
Summary: Enables gamma-butyrobetaine dioxygenase activity. Involved in carnitine biosynthetic process. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and retina. Orthologous to human BBOX1 (gamma-butyrobetaine hydroxylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: carnitine biosynthetic process; MF: dioxygenase activity, gamma-butyrobetaine dioxygenase activity, identical protein binding, iron ion binding, metal ion binding, oxidoreductase activity, zinc ion binding; CC: cytoplasm, cytosol, mitochondrion
Pathways: Carnitine synthesis, L-carnitine biosynthesis, Lysine degradation - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives
UniProt: Q924Y0
Entrez ID: 170442
|
Does Knockout of Ferd3l in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ferd3l
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ferd3l (Fer3 like bHLH transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell development, developmental process, floor plate development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of dopaminergic neuron differentiation, regulation of neurogenesis, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q923Z4
Entrez ID: 114712
|
Does Knockout of Gtf3c3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Gtf3c3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gtf3c3 (general transcription factor IIIC, polypeptide 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transcription by RNA polymerase III; CC: fibrillar center, nuclear membrane, nucleoplasm, transcription factor TFIIIC complex
Pathways: Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter
UniProt: Q3TMP1
Entrez ID: 98488
|
Does Knockout of 1700019D03Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
1700019D03Rik
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: 1700019D03Rik (RIKEN cDNA 1700019D03 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein kinase A regulatory subunit binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9CPS8
Entrez ID: 67080
|
Does Knockout of Cabin1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,286
|
Knockout
|
Cabin1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cabin1 (calcineurin binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of apoptotic process, nucleosome assembly, signal transduction; MF: nucleosome binding, protein domain specific binding, protein phosphatase 2B binding, protein phosphatase inhibitor activity; CC: aggresome, cytosol, nucleoplasm, nucleus
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, DNA Damage/Telomere Stress Induced Senescence, Formation of Senescence-Associated Heterochromatin Foci (SAHF)
UniProt: Q6PFH4, G3X8Q1, Q80X22, A0A1W2P8C4, A0A1W2P819, A0A1W2P755, A0A1W2P8A1, A0A1W2P6X4
Entrez ID: 104248
|
Does Knockout of Hoxb5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Hoxb5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hoxb5 (homeobox B5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, embryonic skeletal system development, embryonic skeletal system morphogenesis, endothelial cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: cytosol, fibrillar center, nucleoplasm, nucleus
Pathways:
UniProt: P09079
Entrez ID: 15413
|
Does Knockout of Dmp1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Dmp1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Dmp1 (dentin matrix protein 1)
Type: protein-coding
Summary: Enables extracellular matrix binding activity. Acts upstream of or within extracellular matrix organization; positive regulation of cell-substrate adhesion; and regulation of enamel mineralization. Located in cytoplasm; extracellular matrix; and nucleus. Is expressed in several structures, including alimentary system; bone; genitourinary system; limb; and nervous system. Used to study autosomal recessive hypophosphatemic rickets. Orthologous to human DMP1 (dentin matrix acidic phosphoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biomineral tissue development, extracellular matrix organization, ossification, positive regulation of cell-substrate adhesion, regulation of enamel mineralization; MF: Hsp70 protein binding, extracellular matrix binding; CC: cytoplasm, extracellular matrix, extracellular region, nucleus
Pathways: ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: O55188
Entrez ID: 13406
|
Does Knockout of Prkaca in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Prkaca
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Prkaca (protein kinase, cAMP dependent, catalytic, alpha)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine protein kinase family. The holoenzyme, protein kinase A (also known as cyclic-AMP dependent protein kinase), mediates cellular response to changes in cyclic-AMP levels. This gene encodes the alpha catalytic subunit of protein kinase A. Protein kinase A-mediated signaling is transduced via phosphorylation of target proteins, and is important for many cellular functions, including mammalian sperm maturation and motility. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: TORC1 signaling, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cAMP/PKA signal transduction, cellular response to cold, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to heat, cellular response to nutrient levels, cellular response to parathyroid hormone stimulus, dorsal/ventral neural tube patterning, interleukin-2-mediated signaling pathway, intracellular potassium ion homeostasis, mRNA processing, mesoderm formation, modulation of chemical synaptic transmission, negative regulation of TORC1 signaling, negative regulation of glycolytic process through fructose-6-phosphate, negative regulation of meiotic cell cycle, negative regulation of smoothened signaling pathway, negative regulation of transcription by RNA polymerase II, neural tube closure, peptidyl-serine phosphorylation, positive regulation of cell population proliferation, positive regulation of cholesterol biosynthetic process, positive regulation of gluconeogenesis, positive regulation of insulin secretion, positive regulation of phagocytosis, positive regulation of protein export from nucleus, postsynaptic modulation of chemical synaptic transmission, protein export from nucleus, protein localization to lipid droplet, regulation of bicellular tight junction assembly, regulation of cell cycle, regulation of cellular respiration, regulation of osteoblast differentiation, regulation of proteasomal protein catabolic process, regulation of protein processing, regulation of synaptic transmission, glutamatergic, sperm capacitation, spontaneous exocytosis of neurotransmitter; MF: ATP binding, cAMP-dependent protein kinase activity, kinase activity, magnesium ion binding, manganese ion binding, nucleotide binding, protein binding, protein domain specific binding, protein kinase A regulatory subunit binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein-containing complex binding, small GTPase binding, transferase activity, ubiquitin protein ligase binding; CC: acrosomal vesicle, axoneme, cAMP-dependent protein kinase complex, cell projection, centrosome, ciliary base, cilium, cytoplasm, cytoplasmic vesicle, cytosol, glutamatergic synapse, membrane, mitochondrion, motile cilium, neuromuscular junction, nuclear speck, nucleoplasm, nucleotide-activated protein kinase complex, nucleus, perinuclear region of cytoplasm, plasma membrane, plasma membrane raft, postsynapse, presynapse, protein-containing complex, sperm flagellum, sperm midpiece
Pathways: AURKA Activation by TPX2, Activation of NMDA receptors and postsynaptic events, Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Apelin signaling pathway - Mus musculus (mouse), Aquaporin-mediated transport, Autophagy - animal - Mus musculus (mouse), Axon guidance, Bile secretion - Mus musculus (mouse), C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, CREB1 phosphorylation through the activation of Adenylate Cyclase, Ca-dependent events, CaM pathway, Calcium signaling pathway - Mus musculus (mouse), Calmodulin induced events, Cardiac conduction, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Centrosome maturation, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Cilium Assembly, Circadian entrainment - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cytokine Signaling in Immune system, DAG and IP3 signaling, DARPP-32 events, Developmental Biology, Dilated cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Factors involved in megakaryocyte development and platelet production, G alpha (i) signalling events, G alpha (s) signalling events, G-protein mediated events, G2/M Transition, GABAergic synapse - Mus musculus (mouse), GLI3 is processed to GLI3R by the proteasome, GPCR downstream signalling, GPER1 signaling, Gap junction - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glucagon signaling in metabolic regulation, Glucagon signaling pathway - Mus musculus (mouse), Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glutamatergic synapse - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HDL assembly, Hedgehog 'off' state, Hedgehog signaling pathway - Mus musculus (mouse), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Innate Immune System, Insulin secretion - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Integration of energy metabolism, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, Ion homeostasis, Long-term potentiation - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK6/MAPK4 signaling, Melanogenesis - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, Mitotic G2-G2/M phases, Mitotic Prometaphase, Morphine addiction - Mus musculus (mouse), Muscle contraction, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Olfactory transduction - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Opioid Signalling, Organelle biogenesis and maintenance, Ovarian steroidogenesis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PKA activation, PKA activation in glucagon signalling, PKA-mediated phosphorylation of CREB, PLC beta mediated events, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Platelet activation - Mus musculus (mouse), Post NMDA receptor activation events, Prion disease - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RET signaling, Rap1 signalling, Ras signaling pathway - Mus musculus (mouse), Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Regulation of insulin secretion, Regulation of lipolysis in adipocytes - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Signaling by Hedgehog, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Taste transduction - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Transmission across Chemical Synapses, Transport of small molecules, VEGFA-VEGFR2 Pathway, Vascular smooth muscle contraction - Mus musculus (mouse), Vasopressin regulates renal water homeostasis via Aquaporins, Vasopressin-regulated water reabsorption - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: P05132
Entrez ID: 18747
|
Does Knockout of Pkn1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Pkn1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pkn1 (protein kinase N1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell apoptotic process, B cell homeostasis, chromatin organization, chromatin remodeling, epithelial cell migration, hyperosmotic response, intracellular signal transduction, negative regulation of B cell proliferation, positive regulation of DNA-templated transcription, post-translational protein modification, regulation of cell motility, regulation of germinal center formation, regulation of immunoglobulin production, regulation of transcription by RNA polymerase II, renal system process, signal transduction, spleen development; MF: ATP binding, chromatin binding, diacylglycerol-dependent serine/threonine kinase activity, histone H3T11 kinase activity, histone binding, histone deacetylase binding, kinase activity, nuclear androgen receptor binding, nucleotide binding, protein binding, protein kinase C binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, small GTPase binding, transcription coactivator activity, transferase activity; CC: cleavage furrow, cytoplasm, cytoplasmic vesicle, endosome, membrane, midbody, nucleus, plasma membrane, protein-containing complex
Pathways: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, NOD-like receptor signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), RAC1 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate PKNs, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Yersinia infection - Mus musculus (mouse)
UniProt: P70268
Entrez ID: 320795
|
Does Knockout of Rlf in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Rlf
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rlf (rearranged L-myc fusion sequence)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of heterochromatin formation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: E9Q532, A2A7F4
Entrez ID: 109263
|
Does Knockout of Zfp354c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Zfp354c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp354c (zinc finger protein 354C)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of sprouting angiogenesis and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; lung; and spleen. Orthologous to human ZNF354C (zinc finger protein 354C). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: angiogenesis, negative regulation of sprouting angiogenesis, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: cytoplasm, membrane, nuclear membrane, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q571J5
Entrez ID: 30944
|
Does Knockout of Hs1bp3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Hs1bp3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Hs1bp3 (HCLS1 binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, cell surface receptor signaling pathway, regulation of apoptotic process; MF: phosphatidylinositol binding, protein binding; CC: endoplasmic reticulum, mitochondrion
Pathways:
UniProt: Q3TC93
Entrez ID: 58240
|
Does Knockout of Sult1c1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Sult1c1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sult1c1 (sulfotransferase family, cytosolic, 1C, member 1)
Type: protein-coding
Summary: Enables aryl sulfotransferase activity. Acts upstream of or within sulfur compound metabolic process. Located in cytoplasm. Is expressed in olfactory epithelium. Orthologous to several human genes including SULT1C3 (sulfotransferase family 1C member 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate metabolic process, sulfation, sulfur compound metabolic process, xenobiotic metabolic process; MF: 3'-phosphoadenosine 5'-phosphosulfate binding, alcohol sulfotransferase activity, aryl sulfotransferase activity, bile-salt sulfotransferase activity, sulfotransferase activity, transferase activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q80VR3
Entrez ID: 20888
|
Does Knockout of Nedd9 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Nedd9
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Nedd9 (neural precursor cell expressed, developmentally down-regulated gene 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell division, cell migration, cell surface receptor protein tyrosine kinase signaling pathway, cilium disassembly, learning or memory, lymphocyte migration into lymphoid organs, negative regulation of cell migration, positive regulation of cell migration, positive regulation of dendritic spine maintenance, positive regulation of immunological synapse formation, positive regulation of lymphocyte chemotaxis, positive regulation of osteoclast differentiation, positive regulation of protein localization, positive regulation of protein tyrosine kinase activity, positive regulation of substrate adhesion-dependent cell spreading, regulation of actin cytoskeleton organization; MF: protein binding, protein tyrosine kinase binding; CC: Golgi apparatus, anchoring junction, basolateral plasma membrane, cell cortex, cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, focal adhesion, immunological synapse, lamellipodium, membrane, mitotic spindle, nucleoplasm, nucleus, plasma membrane, spindle, spindle pole
Pathways:
UniProt: O35177
Entrez ID: 18003
|
Does Knockout of Zfp36l1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Zfp36l1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Zfp36l1 (zinc finger protein 36, C3H type-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, ERK1 and ERK2 cascade, MAPK cascade, T cell differentiation in thymus, apoptotic process, cell population proliferation, cellular response to cAMP, cellular response to epidermal growth factor stimulus, cellular response to fibroblast growth factor stimulus, cellular response to glucocorticoid stimulus, cellular response to hypoxia, cellular response to insulin stimulus, cellular response to peptide hormone stimulus, cellular response to raffinose, cellular response to salt stress, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, chorio-allantoic fusion, embryonic organ development, heart development, mRNA catabolic process, mRNA processing, mRNA transport, mesendoderm development, multicellular organism growth, negative regulation of erythrocyte differentiation, negative regulation of mitotic cell cycle phase transition, neural tube development, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, nuclear-transcribed mRNA catabolic process, deadenylation-independent decay, p38MAPK cascade, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of fat cell differentiation, positive regulation of intracellular mRNA localization, positive regulation of monocyte differentiation, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, proepicardium development, regulation of B cell differentiation, regulation of gene expression, regulation of keratinocyte apoptotic process, regulation of keratinocyte differentiation, regulation of keratinocyte proliferation, regulation of mRNA 3'-end processing, regulation of mRNA stability, regulation of myoblast differentiation, regulation of stem cell proliferation, regulation of translation, response to wounding, spongiotrophoblast layer development, vasculogenesis; MF: 14-3-3 protein binding, DNA binding, RNA binding, mRNA 3'-UTR AU-rich region binding, mRNA binding, metal ion binding, protein binding, zinc ion binding; CC: P-body, cytoplasm, cytosol, nucleus, ribonucleoprotein complex
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Cellular senescence - Mus musculus (mouse), Metabolism of RNA, Regulation of mRNA stability by proteins that bind AU-rich elements
UniProt: P23950
Entrez ID: 12192
|
Does Knockout of Umps in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Umps
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Umps (uridine monophosphate synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' UMP biosynthetic process, 'de novo' pyrimidine nucleobase biosynthetic process, UDP biosynthetic process, UMP biosynthetic process, pyrimidine nucleobase biosynthetic process, pyrimidine nucleotide biosynthetic process; MF: carboxy-lyase activity, catalytic activity, glycosyltransferase activity, identical protein binding, lyase activity, orotate phosphoribosyltransferase activity, orotidine-5'-phosphate decarboxylase activity, transferase activity; CC: cytoplasm, nucleus
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Pyrimidine biosynthesis, Pyrimidine metabolism - Mus musculus (mouse), pyrimidine ribonucleotides <i>de novo</i> biosynthesis, uridine-5,-phosphate biosynthesis
UniProt: P13439
Entrez ID: 22247
|
Does Knockout of Pmp22 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Pmp22
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pmp22 (peripheral myelin protein 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell development, Schwann cell differentiation, Schwann cell migration, actin cytoskeleton organization, adult locomotory behavior, adult walking behavior, aggresome assembly, apoptotic process, autophagy, axon development, basement membrane organization, bleb assembly, cell adhesion, cell differentiation, cellular response to heat, cellular response to unfolded protein, cholesterol metabolic process, fibroblast migration, gliogenesis, immune response, lamellipodium assembly, lipid metabolic process, mating, membrane raft organization, motor behavior, multicellular organism growth, muscle cell development, myelin assembly, myelination, myelination in peripheral nervous system, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of neuron projection development, nervous system development, neuromuscular junction development, skeletal muscle fiber, neuromuscular process, neuronal action potential, neuronal action potential propagation, neuronal ion channel clustering, paranodal junction assembly, peripheral nervous system development, peripheral nervous system neuron axonogenesis, positive regulation of gene expression, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of Schwann cell proliferation, regulation of apoptotic signaling pathway, regulation of cell cycle, regulation of gene expression, regulation of glial cell apoptotic process, regulation of inflammatory response, response to bacterium, response to endoplasmic reticulum stress, striated muscle cell differentiation, transmission of nerve impulse, vestibular reflex; MF: cytoskeletal motor activity, protein binding, protein serine/threonine kinase inhibitor activity; CC: bicellular tight junction, cell surface, compact myelin, integrin complex, laminin complex, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: P16646
Entrez ID: 18858
|
Does Knockout of Ythdf3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Ythdf3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ythdf3 (YTH N6-methyladenosine RNA binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA destabilization, negative regulation of type I interferon-mediated signaling pathway, organelle assembly, positive regulation of translation, positive regulation of translational initiation, regulation of mRNA stability, regulation of trophoblast cell migration, stress granule assembly; MF: N6-methyladenosine-containing RNA reader activity, RNA binding, mRNA binding, ribosome binding; CC: P-body, cytoplasm, cytoplasmic stress granule, cytosol
Pathways:
UniProt: Q8BYK6
Entrez ID: 229096
|
Does Knockout of Rfc3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Rfc3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rfc3 (replication factor C (activator 1) 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP-dependent activity, acting on DNA, DNA binding, DNA clamp loader activity, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, chromosome, nucleus, protein-containing complex
Pathways: Activation of ATR in response to replication stress, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q8R323
Entrez ID: 69263
|
Does Knockout of Defb11 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Defb11
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Defb11 (defensin beta 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, innate immune response in mucosa, response to bacterium; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8R2I7
Entrez ID: 246081
|
Does Knockout of Golt1b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Golt1b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Golt1b (golgi transport 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated transport; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum, membrane, protein-containing complex
Pathways:
UniProt: Q9CR60
Entrez ID: 66964
|
Does Knockout of Cysltr1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Cysltr1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Cysltr1 (cysteinyl leukotriene receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium ion transport, cell surface receptor signaling pathway, cellular response to hypoxia, chemotaxis, endothelium development, establishment of localization in cell, inflammatory response to antigenic stimulus, leukotriene signaling pathway, neuropeptide signaling pathway, positive regulation of angiogenesis, positive regulation of glial cell proliferation, positive regulation of vasoconstriction, reactive oxygen species biosynthetic process, signal transduction; MF: G protein-coupled receptor activity, cysteinyl leukotriene receptor activity, galanin receptor activity, leukotriene receptor activity, protein binding; CC: membrane, plasma membrane
Pathways: Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Leukotriene receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q99JA4
Entrez ID: 58861
|
Does Knockout of Mre11a in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Mre11a
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Mre11a (MRE11A homolog A, double strand break repair nuclease)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA repair, DNA strand resection involved in replication fork processing, R-loop processing, cell population proliferation, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, homologous chromosome pairing at meiosis, homologous recombination, host-mediated suppression of symbiont invasion, meiotic DNA double-strand break formation, meiotic cell cycle, mitochondrial double-strand break repair via homologous recombination, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, mitotic intra-S DNA damage checkpoint signaling, negative regulation of apoptotic process, negative regulation of double-strand break repair via nonhomologous end joining, positive regulation of double-strand break repair, positive regulation of telomere maintenance, sister chromatid cohesion, telomere maintenance, telomeric 3' overhang formation; MF: 3'-5' exonuclease activity, 3'-5'-DNA exonuclease activity, DNA binding, DNA endonuclease activity, DNA helicase activity, endonuclease activity, exonuclease activity, hydrolase activity, identical protein binding, manganese ion binding, metal ion binding, nuclease activity, protein binding, single-stranded DNA endodeoxyribonuclease activity; CC: BRCA1-C complex, Mre11 complex, PML body, chromatin, chromosomal region, chromosome, chromosome, telomeric region, condensed nuclear chromosome, cytoplasm, nucleoplasm, nucleus, perinuclear region of cytoplasm, replication fork, site of double-strand break
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Cytosolic sensors of pathogen-associated DNA , DNA Damage/Telomere Stress Induced Senescence, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through MMEJ (alt-NHEJ), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Immune System, Innate Immune System, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Sensing of DNA Double Strand Breaks, Transcriptional Regulation by TP53
UniProt: Q61216
Entrez ID: 17535
|
Does Knockout of Carf in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Carf
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Carf (calcium response factor)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of DNA-binding transcription factor activity. Located in granular component. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and skeletal muscle tissue. Orthologous to human CARF (calcium responsive transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to calcium ion, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding; CC: granular component, nucleus
Pathways:
UniProt: Q8VHI4
Entrez ID: 241066
|
Does Knockout of Hmgcs2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Hmgcs2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Hmgcs2 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetyl-CoA metabolic process, adipose tissue development, cellular response to amino acid stimulus, cellular response to fatty acid, cellular response to glucocorticoid stimulus, cellular response to hormone stimulus, cellular response to insulin stimulus, cellular response to lipopolysaccharide, cholesterol biosynthetic process, cholesterol metabolic process, farnesyl diphosphate biosynthetic process, mevalonate pathway, isoprenoid biosynthetic process, ketone body biosynthetic process, kidney development, lipid metabolic process, liver development, lung development, midgut development, multicellular organismal response to stress, response to bacterium, response to cAMP, response to ethanol, response to fatty acid, response to glucagon, response to glucocorticoid, response to growth hormone, response to insulin, response to linoleic acid, response to metal ion, response to monosaccharide, response to nutrient, response to peptide hormone, response to prostaglandin F, response to starvation, response to temperature stimulus, response to testosterone, response to triglyceride, response to xenobiotic stimulus, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: acyltransferase activity, hydroxymethylglutaryl-CoA synthase activity, identical protein binding, transferase activity; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Butanoate metabolism - Mus musculus (mouse), Ketone body metabolism, Metabolism, Metabolism of lipids, Metabolism of proteins, Mitochondrial protein degradation, PPAR signaling pathway - Mus musculus (mouse), Synthesis of Ketone Bodies, Terpenoid backbone biosynthesis - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), ketogenesis, mevalonate pathway I, superpathway of cholesterol biosynthesis
UniProt: P54869
Entrez ID: 15360
|
Does Knockout of Lhx8 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Lhx8
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Lhx8 (LIM homeobox protein 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: female gonad development, forebrain neuron development, forebrain neuron differentiation, learning or memory, neuron differentiation, odontogenesis of dentin-containing tooth, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding; CC: female germ cell nucleus, nucleus
Pathways:
UniProt: O35652
Entrez ID: 16875
|
Does Knockout of Htr7 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Htr7
|
cell proliferation
|
Regulatory T cell
|
Gene: Htr7 (5-hydroxytryptamine (serotonin) receptor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor signaling pathway, adenylate cyclase-activating serotonin receptor signaling pathway, behavioral response to pain, chemical synaptic transmission, circadian rhythm, detection of mechanical stimulus involved in sensory perception of pain, dopaminergic neuron differentiation, long-term synaptic potentiation, memory, negative regulation of serotonin secretion, positive regulation of neuron projection development, presynaptic modulation of chemical synaptic transmission, regulation of vein smooth muscle contraction, response to corticosterone, serotonin receptor signaling pathway, signal transduction, smooth muscle contraction, urinary bladder smooth muscle contraction, vasoconstriction; MF: G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, neurotransmitter receptor activity, serotonin receptor activity; CC: axon terminus, cilium, dendrite, membrane, neuronal cell body, nucleoplasm, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse, synaptic vesicle
Pathways: Amine ligand-binding receptors, Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), RHOBTB3 ATPase cycle, Ras signaling pathway - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Serotonin receptors, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P32304
Entrez ID: 15566
|
Does Knockout of Pdcd2l in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Pdcd2l
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pdcd2l (programmed cell death 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, biological_process
Pathways:
UniProt: Q8C5N5
Entrez ID: 68079
|
Does Knockout of Tmem63c in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Tmem63c
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmem63c (transmembrane protein 63c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glomerular filtration, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport; MF: calcium-activated cation channel activity, osmolarity-sensing monoatomic cation channel activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, lysosomal membrane, membrane, plasma membrane
Pathways:
UniProt: Q8CBX0
Entrez ID: 217733
|
Does Knockout of Etf1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Etf1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Etf1 (eukaryotic translation termination factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational termination, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translational termination, ribosome disassembly, translation, translational termination; MF: peptidyl-tRNA hydrolase activity, sequence-specific mRNA binding, translation release factor activity, translation release factor activity, codon specific, translation termination factor activity; CC: cytoplasm, cytosol, cytosolic ribosome, translation release factor complex
Pathways: Eukaryotic Translation Termination, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Post-translational protein modification, Protein hydroxylation, Translation, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q8BWY3
Entrez ID: 225363
|
Does Knockout of Retreg1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Retreg1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Retreg1 (reticulophagy regulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, collagen catabolic process, endoplasmic reticulum organization, mitophagy, negative regulation of neuron apoptotic process, reticulophagy, sensory perception of pain, substrate localization to autophagosome, white fat cell differentiation; MF: endoplasmic reticulum-autophagosome adaptor activity, protein binding; CC: Golgi apparatus, cis-Golgi network, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear body, nucleolus
Pathways:
UniProt: Q8VE91
Entrez ID: 66270
|
Does Knockout of Anapc15 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Anapc15
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Anapc15 (anaphase promoting complex C subunit 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, regulation of mitotic cell cycle spindle assembly checkpoint; CC: anaphase-promoting complex
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P60007
Entrez ID: 75430
|
Does Knockout of Agpat5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Agpat5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Agpat5 (1-acylglycerol-3-phosphate O-acyltransferase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, acylglycerol metabolic process, hematopoietic progenitor cell differentiation, lipid metabolic process, phosphatidylinositol acyl-chain remodeling, phospholipid biosynthetic process; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, acyltransferase activity, transferase activity; CC: endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion, nuclear envelope, nucleolus, nucleus
Pathways: CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Synthesis of PA, phosphatidylglycerol biosynthesis I (plastidic), phosphatidylglycerol biosynthesis II (non-plastidic), phospholipid biosynthesis I, triacylglycerol biosynthesis
UniProt: Q9D1E8
Entrez ID: 52123
|
Does Knockout of Paox in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Paox
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Paox (polyamine oxidase (exo-N4-amino))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: polyamine catabolic process, positive regulation of spermidine biosynthetic process, putrescine biosynthetic process, putrescine catabolic process, spermidine catabolic process, spermine catabolic process, spermine metabolic process; MF: N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity, oxidoreductase activity, polyamine oxidase activity; CC: cytoplasm, peroxisomal matrix, peroxisome
Pathways: Amine Oxidase reactions, Biological oxidations, Interconversion of polyamines, Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, PAOs oxidise polyamines to amines, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Phase I - Functionalization of compounds, Protein localization
UniProt: Q8C0L6
Entrez ID: 212503
|
Does Knockout of Adam26b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Adam26b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Adam26b (a disintegrin and metallopeptidase domain 26B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: male gonad development, proteolysis; MF: metal ion binding, metalloendopeptidase activity, metallopeptidase activity, molecular_function; CC: external side of plasma membrane, membrane, plasma membrane, sperm head plasma membrane
Pathways:
UniProt: Q9CUI8, Q6IMH6
Entrez ID: 382007
|
Does Knockout of Mnt in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Mnt
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Mnt (max binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular senescence, negative regulation of apoptotic signaling pathway, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, identical protein binding, protein binding, protein dimerization activity; CC: nucleoplasm, nucleus
Pathways:
UniProt: O08789
Entrez ID: 17428
|
Does Knockout of Vkorc1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Vkorc1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vkorc1 (vitamin K epoxide reductase complex, subunit 1)
Type: protein-coding
Summary: Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: blood coagulation, bone development, peptidyl-glutamic acid carboxylation, positive regulation of coagulation, regulation of blood coagulation, vitamin K biosynthetic process, vitamin K metabolic process, xenobiotic metabolic process; MF: oxidoreductase activity, quinone binding, vitamin-K-epoxide reductase (warfarin-insensitive) activity, vitamin-K-epoxide reductase (warfarin-sensitive) activity; CC: endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, membrane
Pathways: Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamin K, Metabolism of vitamins and cofactors, Ubiquinone and other terpenoid-quinone biosynthesis - Mus musculus (mouse)
UniProt: Q9CRC0
Entrez ID: 27973
|
Does Knockout of Cox5b in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Cox5b
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cox5b (cytochrome c oxidase subunit 5B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; CC: membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, myelin sheath, respiratory chain complex IV
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: A0A0A6YVR0, Q9D881, F7C106
Entrez ID: 12859
|
Does Knockout of Tbpl2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Tbpl2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Tbpl2 (TATA box binding protein like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, transcription by RNA polymerase II; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, protein binding; CC: cytoplasm, female germ cell nucleus, nucleus
Pathways: Basal transcription factors - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q6SJ95
Entrez ID: 227606
|
Does Knockout of Apeh in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Apeh
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Apeh (acylpeptide hydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid-beta metabolic process, proteolysis; MF: hydrolase activity, identical protein binding, omega peptidase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, cytosol, nuclear membrane
Pathways: Eukaryotic Translation Termination, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Translation
UniProt: Q8R146
Entrez ID: 235606
|
Does Knockout of Dusp19 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Dusp19
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dusp19 (dual specificity phosphatase 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, negative regulation of JNK cascade, negative regulation of MAPK cascade, positive regulation of JNK cascade, positive regulation of MAPK cascade, regulation of JNK cascade; MF: JUN kinase phosphatase activity, MAP-kinase scaffold activity, hydrolase activity, mitogen-activated protein kinase kinase binding, mitogen-activated protein kinase kinase kinase binding, phosphoprotein phosphatase activity, protein binding, protein kinase activator activity, protein kinase inhibitor activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, protein tyrosine/threonine phosphatase activity; CC: cytoplasm
Pathways:
UniProt: Q99N12
Entrez ID: 68082
|
Does Knockout of Ugdh in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ugdh
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ugdh (UDP-glucose dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: UDP-glucuronate biosynthetic process, chondroitin sulfate proteoglycan biosynthetic process, gastrulation with mouth forming second, glycosaminoglycan biosynthetic process, heparan sulfate proteoglycan biosynthetic process, neuron development, protein hexamerization; MF: NAD binding, UDP-glucose 6-dehydrogenase activity, catalytic activity, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: nucleoplasm, nucleus
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Ascorbate and aldarate metabolism - Mus musculus (mouse), Biological oxidations, Formation of the active cofactor, UDP-glucuronate, Glucuronidation, L-ascorbate biosynthesis VI, Metabolism, Pentose and glucuronate interconversions - Mus musculus (mouse), Phase II - Conjugation of compounds, UDP-D-xylose and UDP-D-glucuronate biosynthesis, colanic acid building blocks biosynthesis
UniProt: O70475
Entrez ID: 22235
|
Does Knockout of Ss18 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ss18
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ss18 (SS18, subunit of BAF chromatin remodeling complex)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell morphogenesis, chromatin remodeling, cytoskeleton organization, ephrin receptor signaling pathway, intracellular signal transduction, microtubule cytoskeleton organization, negative regulation of cell differentiation, neuronal stem cell population maintenance, positive regulation of cell population proliferation, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, response to xenobiotic stimulus; MF: transcription coactivator activity; CC: GBAF complex, SWI/SNF complex, chromatin, microtubule cytoskeleton, npBAF complex, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, SWI/SNF chromatin remodelers, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q62280
Entrez ID: 268996
|
Does Knockout of Ppp2r3a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Ppp2r3a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ppp2r3a (protein phosphatase 2, regulatory subunit B'', alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: eye photoreceptor cell differentiation, negative regulation of canonical Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of protein catabolic process, regulation of canonical Wnt signaling pathway, regulation of cell migration involved in somitogenic axis elongation, somatic muscle development, somitogenesis; MF: calcium ion binding, metal ion binding, protein phosphatase regulator activity, protein-macromolecule adaptor activity; CC: protein phosphatase type 2A complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q3V1Y6, B2RXC8, G3X9E8, Q8BXX8
Entrez ID: 235542
|
Does Knockout of Sgip1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Sgip1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sgip1 (SH3-domain GRB2-like (endophilin) interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: clathrin-dependent endocytosis, endocytosis, energy homeostasis, plasma membrane tubulation, positive regulation of eating behavior, positive regulation of feeding behavior, positive regulation of multicellular organism growth, positive regulation of receptor-mediated endocytosis, response to dietary excess, synaptic vesicle endocytosis; MF: SH3 domain binding, microtubule binding, phospholipid binding, protein binding, tubulin binding; CC: AP-2 adaptor complex, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, membrane, plasma membrane, presynapse
Pathways:
UniProt: Q8VD37
Entrez ID: 73094
|
Does Knockout of Gm9755 in Microglial Cell Line causally result in protein/peptide distribution?
| 1
| 1,585
|
Knockout
|
Gm9755
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Gm9755 (Tu translation elongation factor pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100041265
|
Does Knockout of Il1rn in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Il1rn
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Il1rn (interleukin 1 receptor antagonist)
Type: protein-coding
Summary: Predicted to enable cytokine receptor binding activity. Acts upstream of or within insulin secretion and lipid metabolic process. Located in extracellular region and vesicle. Is expressed in skin. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: acute-phase response, fever generation, immune response, inflammatory response, insulin secretion, lipid metabolic process, memory, negative regulation of apoptotic process, negative regulation of cell migration, negative regulation of glutamate secretion, negative regulation of heterotypic cell-cell adhesion, negative regulation of interleukin-1-mediated signaling pathway, negative regulation of membrane potential, response to glucocorticoid, signal transduction; MF: cytokine activity, interleukin-1 receptor antagonist activity, interleukin-1 receptor binding, interleukin-1 type I receptor antagonist activity, interleukin-1 type II receptor antagonist activity, interleukin-1, type I receptor binding, interleukin-1, type II receptor binding; CC: centrosome, cytoplasm, cytosol, extracellular region, extracellular space, nucleoplasm, vesicle
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Signaling by Interleukins
UniProt: P25085
Entrez ID: 16181
|
Does Knockout of Ech1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Ech1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ech1 (enoyl coenzyme A hydratase 1, peroxisomal)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process; MF: catalytic activity, delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity, isomerase activity; CC: cytoplasm, mitochondrion, peroxisome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Protein localization
UniProt: O35459
Entrez ID: 51798
|
Does Knockout of Ttbk1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Ttbk1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ttbk1 (tau tubulin kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: learning or memory, negative regulation of gene expression, positive regulation of astrocyte activation, positive regulation of gene expression, positive regulation of microglial cell activation, positive regulation of protein polymerization, signal transduction; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, tau protein binding, tau-protein kinase activity, transferase activity; CC: cytoplasm, cytosol, microtubule associated complex, microtubule cytoskeleton, neuronal cell body, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q6PCN3
Entrez ID: 106763
|
Does Knockout of Fn3krp in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Fn3krp
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fn3krp (fructosamine 3 kinase related protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein-ribulosamine 3-kinase activity, transferase activity; CC: cellular_component, cytosol
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification
UniProt: Q8K274
Entrez ID: 238024
|
Does Knockout of Lsm10 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Lsm10
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Lsm10 (U7 snRNP-specific Sm-like protein LSM10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, positive regulation of G1/S transition of mitotic cell cycle; MF: RNA binding, U7 snRNA binding, histone pre-mRNA DCP binding, snRNA binding; CC: Cajal body, U7 snRNP, cytoplasmic U snRNP body, nuclear body, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs
UniProt: Q8QZX5
Entrez ID: 116748
|
Does Knockout of Trip12 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Trip12
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Trip12 (thyroid hormone receptor interactor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, heterochromatin boundary formation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of embryonic development, ubiquitin-dependent protein catabolic process; MF: nuclear thyroid hormone receptor binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: nuclear speck, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: G5E870
Entrez ID: 14897
|
Does Knockout of Mthfd1l in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Mthfd1l
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mthfd1l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 10-formyltetrahydrofolate biosynthetic process, carboxylic acid biosynthetic process, embryonic neurocranium morphogenesis, embryonic viscerocranium morphogenesis, folic acid-containing compound metabolic process, formate biosynthetic process, formate metabolic process, neural tube closure, one-carbon metabolic process, tetrahydrofolate interconversion, tetrahydrofolate metabolic process; MF: ATP binding, formate-tetrahydrofolate ligase activity, ligase activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, nucleotide binding, protein homodimerization activity; CC: cytosol, mitochondrial matrix, mitochondrion
Pathways: Metabolism, Metabolism of folate and pterines, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, One carbon pool by folate - Mus musculus (mouse), folate polyglutamylation, folate transformations I, folate transformations II (plants)
UniProt: Q3V3R1
Entrez ID: 270685
|
Does Knockout of Has1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Has1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Has1 (hyaluronan synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to platelet-derived growth factor stimulus, estrous cycle, extracellular matrix assembly, glycosaminoglycan biosynthetic process, hyaluronan biosynthetic process, negative regulation of fibroblast migration, polysaccharide biosynthetic process; MF: glycosyltransferase activity, hyaluronan synthase activity, identical protein binding, transferase activity; CC: Golgi apparatus, cytoplasm, membrane, plasma membrane
Pathways: Glycosaminoglycan metabolism, Hyaluronan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q61647
Entrez ID: 15116
|
Does Knockout of Rpl13 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Rpl13
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Rpl13 (ribosomal protein L13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, bone development, cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, nucleolus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P47963
Entrez ID: 270106
|
Does Knockout of Rp9 in Regulatory T cell causally result in protein/peptide accumulation?
| 1
| 1,482
|
Knockout
|
Rp9
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Rp9 (retinitis pigmentosa 9 (human))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cognition; MF: metal ion binding, protein binding, zinc ion binding; CC: nuclear speck, nucleus, signal recognition particle receptor complex
Pathways: Spliceosome - Mus musculus (mouse)
UniProt: P97762
Entrez ID: 55934
|
Does Knockout of Tmem262 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Tmem262
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tmem262 (transmembrane protein 262)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: CatSper complex, cell projection, cilium, membrane, motile cilium, plasma membrane
Pathways:
UniProt: D3Z338
Entrez ID: 433215
|
Does Knockout of Rhox2d in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Rhox2d
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rhox2d (reproductive homeobox 2D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: W4VSN9
Entrez ID: 434760
|
Does Knockout of Hsf4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Hsf4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hsf4 (heat shock transcription factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lens fiber cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein phosphatase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nuclear speck, nucleus
Pathways:
UniProt: Q9R0L1
Entrez ID: 26386
|
Does Knockout of Rnf103 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Rnf103
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rnf103 (ring finger protein 103)
Type: protein-coding
Summary: This gene encodes a member of the RING finger family of E3 ubiquitin-protein ligases. These proteins catalyze the transfer of the ubiquitin protein from a ubiquitin E2 enzyme to a protein substrate. Homozygous knockout mice for this gene exhibit enhanced anxiety-like behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
Gene Ontology: BP: ERAD pathway, protein ubiquitination; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9R1W3
Entrez ID: 22644
|
Does Knockout of Rps6ka6 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Rps6ka6
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Rps6ka6 (ribosomal protein S6 kinase polypeptide 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, TORC1 signaling, intracellular signal transduction, negative regulation of ERK1 and ERK2 cascade, negative regulation of embryonic development, negative regulation of mesoderm development; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, ribosomal protein S6 kinase activity, transferase activity; CC: cytoplasm, cytosol, fibrillar center, mitochondrion, nucleolus, nucleoplasm, nucleus, synapse
Pathways: Activation of NMDA receptors and postsynaptic events, CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neurotrophin signaling pathway - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Post NMDA receptor activation events, Progesterone-mediated oocyte maturation - Mus musculus (mouse), RSK activation, Thermogenesis - Mus musculus (mouse), Transmission across Chemical Synapses, Yersinia infection - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q7TPS0
Entrez ID: 67071
|
Does Knockout of Trmt5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Trmt5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Trmt5 (TRM5 tRNA methyltransferase 5)
Type: protein-coding
Summary: Predicted to enable tRNA methyltransferase activity. Predicted to be involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Predicted to be located in nucleus. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: methylation, mitochondrial tRNA methylation, tRNA N1-guanine methylation, tRNA methylation, tRNA processing; MF: methyltransferase activity, tRNA (guanine(37)-N1)-methyltransferase activity, tRNA methyltransferase activity, transferase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion, nucleus
Pathways:
UniProt: Q9D0C4
Entrez ID: 76357
|
Does Knockout of Erich2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Erich2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Erich2 (glutamate rich 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q1A6, D3Z5X9, Q9D4B3, F6WLA9
Entrez ID: 66748
|
Does Knockout of Rwdd4a in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Rwdd4a
|
cell cycle progression
|
breast epithelium
|
Gene: Rwdd4a (RWD domain containing 4A)
Type: protein-coding
Summary: Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human RWDD4 (RWD domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q9CPR1
Entrez ID: 192174
|
Does Knockout of Naglu in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Naglu
|
cell cycle progression
|
breast epithelium
|
Gene: Naglu (alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, adult behavior, amyloid precursor protein metabolic process, aorta development, aorta morphogenesis, astrocyte activation, astrocyte differentiation, autophagy, cardiac muscle cell development, cell surface receptor signaling pathway via STAT, cellular response to oxidative stress, cerebellar Purkinje cell layer development, collagen metabolic process, cone retinal bipolar cell differentiation, cytoplasm organization, determination of adult lifespan, endothelium development, energy homeostasis, exploration behavior, ganglioside metabolic process, gene expression, glycoprotein metabolic process, glycosaminoglycan metabolic process, hair follicle morphogenesis, heart development, heart valve development, heparan sulfate proteoglycan catabolic process, heparan sulfate proteoglycan metabolic process, heparin proteoglycan metabolic process, hormone metabolic process, inflammatory response, inner ear receptor cell development, left ventricular cardiac muscle tissue morphogenesis, limb development, lipid catabolic process, liver development, locomotor rhythm, locomotory behavior, lysosome organization, maintenance of blood-brain barrier, microglia differentiation, microglial cell activation, middle ear morphogenesis, mitral valve morphogenesis, motor behavior, multicellular organismal-level iron ion homeostasis, nerve development, neurogenesis, neuroinflammatory response, proteasome-mediated ubiquitin-dependent protein catabolic process, protein processing, proteoglycan metabolic process, response to disaccharide, response to lipopolysaccharide, response to wounding, retina development in camera-type eye, retinal rod cell development, rod bipolar cell differentiation, superoxide metabolic process, system development, toll-like receptor 4 signaling pathway, vacuole organization, vasculature development, vesicle tethering; MF: alpha-N-acetylglucosaminidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, iron ion sequestering activity; CC: extracellular exosome, lysosomal lumen, membrane, vacuole
Pathways: Glycosaminoglycan degradation - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG degradation, Heparan sulfate/heparin (HS-GAG) metabolism, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: O88325
Entrez ID: 27419
|
Does Knockout of Cinp in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Cinp
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cinp (cyclin dependent kinase 2 interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, biological_process, cell division, ribosomal large subunit biogenesis, ribosome biogenesis; MF: molecular_function, preribosome binding; CC: cellular_component, nucleus
Pathways:
UniProt: Q9D0V8
Entrez ID: 67236
|
Does Knockout of Msl2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Msl2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Msl2 (MSL complex subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, chromatin organization, epigenetic regulation of gene expression, positive regulation of DNA-templated transcription, protein monoubiquitination, protein ubiquitination; MF: histone H2B ubiquitin ligase activity, metal ion binding, promoter-enhancer loop anchoring activity, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: MSL complex, chromatin, chromosome, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q69ZF8
Entrez ID: 77853
|
Does Knockout of Naa35 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Naa35
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Naa35 (N(alpha)-acetyltransferase 35, NatC auxiliary subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of apoptotic process, smooth muscle cell proliferation; CC: NatC complex, cytoplasm, cytosol, nucleoplasm, plasma membrane
Pathways:
UniProt: Q6PHQ8
Entrez ID: 78689
|
Does Knockout of Zfand4 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Zfand4
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Zfand4 (zinc finger, AN1-type domain 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: D3Z3C6
Entrez ID: 67492
|
Does Knockout of Ivns1abp in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Ivns1abp
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Ivns1abp (influenza virus NS1A binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of protein ubiquitination, proteasome-mediated ubiquitin-dependent protein catabolic process, response to virus; MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, cytoskeleton, cytosol, nucleus
Pathways:
UniProt: Q920Q8
Entrez ID: 117198
|
Does Knockout of Defa26 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Defa26
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Defa26 (defensin, alpha, 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, disruption of plasma membrane integrity in another organism, innate immune response, killing by host of symbiont cells, killing of cells of another organism, positive regulation of interleukin-8 production, positive regulation of membrane permeability, protein homotetramerization; MF: pore-forming activity, protein homodimerization activity; CC: extracellular region, extracellular space, midbody, secretory granule
Pathways: Alpha-defensins, Antimicrobial peptides, Defensins, Immune System, Innate Immune System, NOD-like receptor signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Staphylococcus aureus infection - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q3L180
Entrez ID: 626708
|
Does Knockout of Ankle2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Ankle2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ankle2 (ankyrin repeat and LEM domain containing 2)
Type: protein-coding
Summary: Predicted to enable protein kinase inhibitor activity and protein phosphatase 2A binding activity. Predicted to be involved in several processes, including mitotic nuclear membrane reassembly; negative regulation of apoptotic process; and negative regulation of phosphorylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, central nervous system development, mitotic nuclear membrane reassembly, negative regulation of apoptotic process, negative regulation of phosphorylation, nervous system development, nuclear membrane reassembly; MF: protein kinase inhibitor activity, protein phosphatase 2A binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Cell Cycle, Cell Cycle, Mitotic, Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Nuclear Envelope (NE) Reassembly, RAC2 GTPase cycle, RHO GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6P1H6
Entrez ID: 71782
|
Does Knockout of Vmn1r122 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Vmn1r122
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r122 (vomeronasal 1 receptor 122)
Type: protein-coding
Summary: vomeronasal 1 receptor 122
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: K7N726
Entrez ID: 435951
|
Does Knockout of Parn in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Parn
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Parn (poly(A)-specific ribonuclease (deadenylation nuclease))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, box H/ACA sno(s)RNA 3'-end processing, lncRNA processing, mRNA catabolic process, miRNA catabolic process, negative regulation of macromolecule metabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA poly(A) tail shortening, poly(A)-dependent snoRNA 3'-end processing, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of telomere maintenance via telomerase, priRNA 3'-end processing, regulation of RNA stability, regulation of telomerase RNA localization to Cajal body, siRNA 3'-end processing, telomerase RNA stabilization; MF: 3'-5'-RNA exonuclease activity, RNA binding, cation binding, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, poly(A)-specific ribonuclease activity, protein binding, protein kinase binding, telomerase RNA binding; CC: cytoplasm, glutamatergic synapse, nuclear speck, nucleolus, nucleus, postsynapse
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Metabolism of RNA, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements
UniProt: Q8VDG3
Entrez ID: 74108
|
Does Knockout of Slc25a54 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Slc25a54
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Slc25a54 (solute carrier family 25, member 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ADP transport, ATP transport, transmembrane transport; MF: ATP transmembrane transporter activity, antiporter activity, calcium ion binding, metal ion binding; CC: chromatoid body, cytosol, membrane, microtubule organizing center, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: E0CY52, B1AUS6
Entrez ID: 74686
|
Does Knockout of Mcm6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Mcm6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mcm6 (minichromosome maintenance complex component 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA replication initiation, double-strand break repair via break-induced replication, mitotic DNA replication, premeiotic DNA replication; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding, single-stranded 3'-5' DNA helicase activity, single-stranded DNA binding; CC: CMG complex, MCM complex, chromosome, cytosol, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, DNA replication - Mus musculus (mouse), G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: P97311
Entrez ID: 17219
|
Does Knockout of Srsf7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Srsf7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Srsf7 (serine and arginine-rich splicing factor 7)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple protein-coding and non-protein-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2022].
Gene Ontology: BP: RNA splicing, cellular response to leukemia inhibitory factor, mRNA processing, mRNA transport, negative regulation of mRNA splicing, via spliceosome, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, metal ion binding, nucleic acid binding, protein binding, protein domain specific binding, zinc ion binding; CC: cytoplasm, nuclear speck, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Gene expression (Transcription), Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q8BL97
Entrez ID: 225027
|
Does Knockout of Rad21 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Rad21
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rad21 (RAD21 cohesin complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, apoptotic process, cell division, chromatin looping, chromosome segregation, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of gene expression, negative regulation of glial cell apoptotic process, negative regulation of interleukin-1 beta production, negative regulation of mitotic metaphase/anaphase transition, negative regulation of neuron apoptotic process, negative regulation of tumor necrosis factor production, positive regulation of gene expression, positive regulation of interleukin-10 production, positive regulation of sister chromatid cohesion, protein localization to chromatin, regulation of transcription by RNA polymerase II, replication-born double-strand break repair via sister chromatid exchange, response to hypoxia, sister chromatid cohesion; MF: DNA-binding transcription factor binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, lncRNA binding, protein binding; CC: chromatin, chromosome, chromosome, centromeric region, cohesin complex, condensed nuclear chromosome, cytoplasm, cytosol, meiotic cohesin complex, midbody, mitotic cohesin complex, nuclear matrix, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cohesin Loading onto Chromatin, Establishment of Sister Chromatid Cohesion, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Telophase/Cytokinesis, Post-translational protein modification, Resolution of Sister Chromatid Cohesion, S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, Separation of Sister Chromatids
UniProt: Q61550
Entrez ID: 19357
|
Does Knockout of Gfi1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Gfi1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gfi1 (growth factor independent 1 transcription repressor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cell fate commitment, cellular response to lipopolysaccharide, double-strand break repair via homologous recombination, inner ear auditory receptor cell differentiation, inner ear morphogenesis, mechanosensory behavior, negative regulation of DNA-templated transcription, negative regulation of NF-kappaB transcription factor activity, negative regulation of cell fate specification, negative regulation of double-strand break repair via homologous recombination, negative regulation of neuron projection development, negative regulation of transcription by RNA polymerase II, negative regulation of vitamin D biosynthetic process, positive regulation of cell fate specification, positive regulation of interleukin-6-mediated signaling pathway, regulation of toll-like receptor signaling pathway, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, enzyme-substrate adaptor activity, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: nuclear body, nuclear matrix, nucleoplasm, nucleus, transcription repressor complex
Pathways:
UniProt: P70338
Entrez ID: 14581
|
Does Knockout of Ndufaf7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Ndufaf7
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ndufaf7 (NADH:ubiquinone oxidoreductase complex assembly factor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, mitochondrial respiratory chain complex I assembly, peptidyl-arginine methylation, to symmetrical-dimethyl arginine; MF: enzyme binding, methyltransferase activity, protein-arginine omega-N symmetric methyltransferase activity, transferase activity; CC: mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: Q9CWG8
Entrez ID: 73694
|
Does Knockout of Vkorc1l1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Vkorc1l1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Vkorc1l1 (vitamin K epoxide reductase complex, subunit 1-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress, peptidyl-glutamic acid carboxylation, vitamin K metabolic process; MF: oxidoreductase activity, quinone binding, vitamin-K-epoxide reductase (warfarin-sensitive) activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamin K, Metabolism of vitamins and cofactors, Ubiquinone and other terpenoid-quinone biosynthesis - Mus musculus (mouse)
UniProt: Q6TEK5
Entrez ID: 69568
|
Does Knockout of Taf1b in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Taf1b
|
phagocytosis
|
macrophage
|
Gene: Taf1b (TATA-box binding protein associated factor, RNA polymerase I, B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, nucleolar large rRNA transcription by RNA polymerase I, transcription by RNA polymerase I; MF: DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: RNA polymerase I core factor complex, RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination
UniProt: P97358
Entrez ID: 21340
|
Does Knockout of Fgf4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Fgf4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fgf4 (fibroblast growth factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process involved in morphogenesis, cartilage condensation, cell differentiation, cellular response to leukemia inhibitory factor, chondroblast differentiation, cranial suture morphogenesis, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, epithelial cell apoptotic process, fibroblast growth factor receptor signaling pathway, mesenchymal cell proliferation, negative regulation of apoptotic process, neurogenesis, odontogenesis of dentin-containing tooth, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of cell division, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of cell migration, regulation of endothelial cell chemotaxis to fibroblast growth factor, regulation of gene expression, somatic stem cell population maintenance, stem cell population maintenance; MF: fibroblast growth factor receptor binding, growth factor activity, protein binding; CC: cytoplasm, extracellular region, extracellular space
Pathways: Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, FGFR1 ligand binding and activation, FGFR1c ligand binding and activation, FGFR2 ligand binding and activation, FGFR2c ligand binding and activation, FGFR3 ligand binding and activation, FGFR3c ligand binding and activation, FGFR4 ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Gastric cancer - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Phospholipase C-mediated cascade: FGFR1, Phospholipase C-mediated cascade; FGFR2, Phospholipase C-mediated cascade; FGFR3, Phospholipase C-mediated cascade; FGFR4, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: P11403
Entrez ID: 14175
|
Does Knockout of Cox18 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,286
|
Knockout
|
Cox18
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cox18 (cytochrome c oxidase assembly protein 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly, protein insertion into membrane, protein insertion into mitochondrial inner membrane from matrix, protein insertion into mitochondrial membrane, respiratory chain complex IV assembly; MF: membrane insertase activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: Q8VC74
Entrez ID: 231430
|
Does Knockout of Eda2r in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Eda2r
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Eda2r (ectodysplasin A2 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cytokine-mediated signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of JNK cascade, positive regulation of canonical NF-kappaB signal transduction, programmed cell death, tumor necrosis factor-mediated signaling pathway; MF: signaling receptor activity, transmembrane signaling receptor activity, tumor necrosis factor receptor activity; CC: membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, NF-kappa B signaling pathway - Mus musculus (mouse), TNFR2 non-canonical NF-kB pathway, TNFs bind their physiological receptors
UniProt: Q8BX35
Entrez ID: 245527
|
Does Knockout of Pnoc in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Pnoc
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Pnoc (prepronociceptin)
Type: protein-coding
Summary: This gene encodes the precursor for neuropeptides that have been implicated in a wide range of physiological roles such as transmission and sensitivity to pain, learning, memory, anxiety and depression, in the central nervous system. The encoded protein is a precursor that is proteolytically processed to generate multiple biologically active peptides including nociceptin and nocistatin which have opposite functions in pain transmission. Mice lacking the encoded protein display increased anxiety, elevated basal pain threshold and impaired adaptation to repeated stress. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: cellular response to ethanol, chemical synaptic transmission, drinking behavior, gamma-aminobutyric acid secretion, neurotransmission, modulation of excitatory postsynaptic potential, modulation of inhibitory postsynaptic potential, neuron-neuron synaptic transmission, neuropeptide signaling pathway, regulation of synaptic transmission, GABAergic, regulation of synaptic transmission, glutamatergic, response to ethanol, sensory perception, sensory perception of pain; MF: opioid peptide activity, opioid receptor binding, receptor ligand activity; CC: axon terminus, dendrite, extracellular region, neuronal cell body, plasma membrane, synaptic membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q64387
Entrez ID: 18155
|
Does Knockout of Atp6ap2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Atp6ap2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Atp6ap2 (ATPase, H+ transporting, lysosomal accessory protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiotensin maturation, central nervous system maturation, eye pigmentation, head morphogenesis, lysosomal lumen acidification, positive regulation of Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of transforming growth factor beta1 production, regulation of MAPK cascade, rostrocaudal neural tube patterning, synaptic vesicle lumen acidification; CC: apical plasma membrane, autophagosome membrane, axon, bounding membrane of organelle, cell body, cell projection, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, dendritic spine membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, external side of plasma membrane, extracellular space, lysosomal membrane, lysosome, membrane, plasma membrane, postsynaptic membrane, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Immune System, Innate Immune System, Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, Neutrophil degranulation, Peptide hormone metabolism, Renin-angiotensin system - Mus musculus (mouse)
UniProt: Q9CYN9
Entrez ID: 70495
|
Does Knockout of Mrps28 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Mrps28
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mrps28 (mitochondrial ribosomal protein S28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CY16
Entrez ID: 66230
|
Does Knockout of Faap100 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Faap100
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Faap100 (Fanconi anemia core complex associated protein 100)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, interstrand cross-link repair; MF: DNA binding, molecular_function; CC: Fanconi anaemia nuclear complex, chromatin, cytosol, nucleoplasm, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: A2ACJ2
Entrez ID: 71885
|
Does Knockout of Gnrhr in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Gnrhr
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gnrhr (gonadotropin releasing hormone receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to gonadotropin-releasing hormone, cellular response to hormone stimulus, negative regulation of cell population proliferation, signal transduction; MF: G protein-coupled receptor activity, gonadotropin-releasing hormone receptor activity, growth hormone-releasing hormone receptor activity, protein-hormone receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GnRH signaling pathway - Mus musculus (mouse), Hormone ligand-binding receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q01776
Entrez ID: 14715
|
Does Knockout of Sbpl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Sbpl
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sbpl (spermine binding protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell migration; MF: carbohydrate binding, molecular_function; CC: apicolateral plasma membrane, cytoplasm, extracellular region, extracellular space, plasma membrane
Pathways:
UniProt: Q3TUY3, Q9CPP2
Entrez ID: 638345
|
Does Knockout of Mgst3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Mgst3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mgst3 (microsomal glutathione S-transferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, cellular oxidant detoxification, leukotriene biosynthetic process, leukotriene metabolic process, lipid metabolic process, prostanoid metabolic process; MF: glutathione peroxidase activity, glutathione transferase activity, identical protein binding, leukotriene-C4 synthase activity, lyase activity, oxidoreductase activity, transferase activity; CC: endoplasmic reticulum, membrane, mitochondrial outer membrane, mitochondrion, nuclear envelope
Pathways: Aflatoxin activation and detoxification, Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: Q9CPU4
Entrez ID: 66447
|
Does Knockout of Ttc8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Ttc8
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ttc8 (tetratricopeptide repeat domain 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, axon guidance, camera-type eye photoreceptor cell differentiation, cell projection organization, cilium assembly, establishment of anatomical structure orientation, establishment of epithelial cell apical/basal polarity, establishment of planar polarity, fat cell differentiation, inner ear receptor cell stereocilium organization, multi-ciliated epithelial cell differentiation, multicellular organism growth, non-motile cilium assembly, olfactory bulb development, protein localization to plasma membrane, protein transport, regulation of protein localization, regulation of stress fiber assembly, renal tubule development, sensory perception, sensory perception of smell; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding; CC: BBSome, cell projection, centriolar satellite, centriole, centrosome, ciliary basal body, ciliary membrane, cilium, cytoplasm, cytoskeleton, fibrillar center, membrane, non-motile cilium, photoreceptor connecting cilium, plasma membrane
Pathways: BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q8VD72
Entrez ID: 76260
|
Does Knockout of Rps14 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Rps14
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rps14 (ribosomal protein S14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, erythrocyte differentiation, maturation of SSU-rRNA, negative regulation of transcription by RNA polymerase II, ribosomal small subunit assembly, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, mRNA 5'-UTR binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, mitochondrion, nucleolus, nucleus, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62264
Entrez ID: 20044
|
Does Knockout of Fsd1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Fsd1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fsd1 (fibronectin type 3 and SPRY domain-containing protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cytoplasmic microtubule organization, regulation of cell division, regulation of cytokinesis, regulation of mitotic spindle organization; MF: identical protein binding, microtubule binding; CC: centrosome, cleavage furrow, cytoplasm, cytoskeleton, cytosol, microtubule, nucleus
Pathways:
UniProt: Q7TPM6
Entrez ID: 240121
|
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