prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Prim1 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Prim1
|
response to virus
|
Microglial Cell Line
|
Gene: Prim1 (DNA primase, p49 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA replication initiation, DNA replication, synthesis of primer; MF: DNA-directed RNA polymerase activity, magnesium ion binding, metal ion binding, nucleotidyltransferase activity, protein binding, ribonucleotide binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, alpha DNA polymerase:primase complex
Pathways: Activation of the pre-replicative complex, Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Mus musculus (mouse), DNA replication initiation, DNA strand elongation, E2F mediated regulation of DNA replication, Extension of Telomeres, G1/S Transition, Inhibition of replication initiation of damaged DNA by RB1/E2F1, Lagging Strand Synthesis, Leading Strand Synthesis, Mitotic G1 phase and G1/S transition, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the lagging strand, Removal of the Flap Intermediate, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: P20664
Entrez ID: 19075
|
Does Knockout of Cnmd in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Cnmd
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cnmd (chondromodulin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cartilage development, cell differentiation, endothelial cell morphogenesis, negative regulation of angiogenesis, negative regulation of endothelial cell proliferation, negative regulation of vascular endothelial growth factor receptor signaling pathway; CC: endomembrane system, extracellular region, membrane
Pathways:
UniProt: Q9Z1F6
Entrez ID: 16840
|
Does Knockout of Traf3 in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 1
| 2,198
|
Knockout
|
Traf3
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Traf3 (TNF receptor-associated factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Toll signaling pathway, antiviral innate immune response, apoptotic process, cell surface receptor signaling pathway, immune system process, innate immune response, mRNA transcription, negative regulation of NF-kappaB transcription factor activity, positive regulation of type I interferon production, regulation of apoptotic process, regulation of canonical NF-kappaB signal transduction, regulation of cytokine production, regulation of defense response to virus, regulation of interferon-beta production, regulation of proteolysis, regulation of type I interferon production, signal transduction, toll-like receptor 4 signaling pathway, toll-like receptor signaling pathway, tumor necrosis factor-mediated signaling pathway; MF: enzyme binding, identical protein binding, metal ion binding, protein binding, protein kinase binding, protein phosphatase binding, signaling adaptor activity, thioesterase binding, transferase activity, tumor necrosis factor receptor binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: CD40 receptor complex, cytoplasm, cytoplasmic side of plasma membrane, endosome, endosome membrane, mitochondrion
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Alcoholic liver disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Deubiquitination, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, MyD88-independent TLR4 cascade , NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Ovarian tumor domain proteases, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Small cell lung cancer - Mus musculus (mouse), TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNF signaling pathway - Mus musculus (mouse), TNFR2 non-canonical NF-kB pathway, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q60803
Entrez ID: 22031
|
Does Knockout of Rpl35 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Rpl35
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rpl35 (ribosomal protein L35)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation, translation at postsynapse, translation at presynapse; MF: mRNA binding, protein binding, ribonucleoprotein complex binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6ZWV7
Entrez ID: 66489
|
Does Knockout of Htatip2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Htatip2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Htatip2 (HIV-1 Tat interactive protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-amino acid biosynthetic process, positive regulation of programmed cell death, positive regulation of transcription by RNA polymerase II, regulation of translation; MF: NAD binding, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, protein serine/threonine kinase activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q9Z2G9
Entrez ID: 53415
|
Does Knockout of Nup214 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Nup214
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nup214 (nucleoporin 214)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, intracellular protein transport, mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein export from nucleus, protein import into nucleus, protein transport, regulation of cell cycle, regulation of nucleocytoplasmic transport; MF: nuclear export signal receptor activity, nuclear localization sequence binding, structural constituent of nuclear pore; CC: cytoplasmic side of nuclear pore, nuclear envelope, nuclear pore, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HuR (ELAVL1) binds and stabilizes mRNA, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Regulation of mRNA stability by proteins that bind AU-rich elements, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q80U93
Entrez ID: 227720
|
Does Knockout of Il9r in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Il9r
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Il9r (interleukin 9 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, B cell proliferation, immunoglobulin mediated immune response, interleukin-9-mediated signaling pathway, positive regulation of cell growth; MF: cytokine receptor activity, interleukin-9 binding, interleukin-9 receptor activity; CC: cell surface, external side of plasma membrane, extracellular region, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Immune System, Interleukin-2 family signaling, Interleukin-9 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Signaling by Interleukins
UniProt: Q01114
Entrez ID: 16199
|
Does Knockout of Slc4a4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Slc4a4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slc4a4 (solute carrier family 4 (anion exchanger), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicarbonate transport, establishment of localization in cell, inorganic anion transport, monoatomic anion transmembrane transport, monoatomic anion transport, monoatomic ion transport, positive regulation of glycolytic process, regulation of intracellular pH, regulation of membrane potential, regulation of pH, sodium ion export across plasma membrane, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: identical protein binding, monoatomic anion transmembrane transporter activity, protein binding, sodium:bicarbonate symporter activity, solute:inorganic anion antiporter activity, symporter activity; CC: basolateral plasma membrane, cell surface, cytosol, membrane, plasma membrane
Pathways: Bicarbonate transporters, Bile secretion - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Proximal tubule bicarbonate reclamation - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Transport of small molecules
UniProt: O88343
Entrez ID: 54403
|
Does Knockout of Hnrnpdl in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Hnrnpdl
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Hnrnpdl (heterogeneous nuclear ribonucleoprotein D-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA metabolic process, regulation of gene expression; MF: DNA binding, RNA binding, double-stranded DNA binding, nucleic acid binding, poly(A) binding, poly(G) binding, single-stranded DNA binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus, synapse
Pathways:
UniProt: F6ZKM7, D3YTQ3, F6VQH5
Entrez ID: 50926
|
Does Knockout of Ulk2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Ulk2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ulk2 (unc-51 like kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, axon extension, axon guidance, axonogenesis, collateral sprouting, intracellular protein localization, mitophagy, negative regulation of collateral sprouting, nervous system development, piecemeal microautophagy of the nucleus, regulation of autophagy, response to starvation, reticulophagy, signal transduction, somatic sensory system development; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: autophagosome, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, membrane, phagophore assembly site, phagophore assembly site membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9QY01
Entrez ID: 29869
|
Does Knockout of Nrl in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Nrl
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nrl (neural retina leucine zipper gene)
Type: protein-coding
Summary: This gene encodes a member of the basic leucine zipper domain family of transcription factors. The encoded protein is preferentially expressed in the retina and is necessary for rod photoreceptor development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, retinal rod cell development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, leucine zipper domain binding, promoter-specific chromatin binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: P54846
Entrez ID: 18185
|
Does Knockout of Bcs1l in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Bcs1l
|
phagocytosis
|
macrophage
|
Gene: Bcs1l (BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone)
Type: protein-coding
Summary: The protein encoded by this gene is a chaperone protein that is involved in the assembly of complex III (CIII), one of the five protein complexes of the mitochondrial respiratory chain, and is necessary for the insertion of the Rieske iron-sulfur (RISP) and Qcr10p proteins into the precomplex. Studies from the yeast ortholog of this protein indicate that it is targeted to the inner membrane of the mitochondria, despite the absence of an N-terminal targeting sequence. Positively charged amino acids located C-terminal to the transmembrane domain are thought to act as an internal targeting signal (PMID:8599931). Mutations in the human ortholog of this gene have been associated with GRACILE syndrome, characterized by Growth retardation, Amino aciduria, Cholestasis, Iron overload, Lactic acidosis, and Early death. Mouse models with the corresponding mutation mimic the phenotype of GRACILE syndrome and display decreased complex III activity and decreased electron transport capacity (PMID:21274865). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly, mitochondrial respiratory chain complex I assembly, mitochondrial respiratory chain complex III assembly, mitochondrion organization, protein insertion into mitochondrial inner membrane from matrix, protein transmembrane transport; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, mitochondrial protein-transporting ATPase activity, nucleotide binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CZP5
Entrez ID: 66821
|
Does Knockout of Cpt1c in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Cpt1c
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cpt1c (carnitine palmitoyltransferase 1c)
Type: protein-coding
Summary: Enables palmitoyl-(protein) hydrolase activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in axon; dendrite; and endoplasmic reticulum. Part of AMPA glutamate receptor complex. Is active in endoplasmic reticulum membrane; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 73. Orthologous to human CPT1C (carnitine palmitoyltransferase 1C). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: carnitine metabolic process, fatty acid metabolic process, lipid metabolic process, macromolecule depalmitoylation, regulation of postsynaptic membrane neurotransmitter receptor levels; MF: acyltransferase activity, carnitine O-palmitoyltransferase activity, catalytic activity, hydrolase activity, palmitoyl-(protein) hydrolase activity, transferase activity; CC: AMPA glutamate receptor complex, axon, cell projection, dendrite, dendritic spine, endoplasmic reticulum, endoplasmic reticulum membrane, glutamatergic synapse, membrane, mitochondrion, postsynapse, synapse
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), PPAR signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse)
UniProt: Q8BGD5
Entrez ID: 78070
|
Does Knockout of Gpr88 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Gpr88
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gpr88 (G-protein coupled receptor 88)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, adrenergic receptor signaling pathway, cellular response to light stimulus, detection of visible light, locomotory behavior, motor learning, neuromuscular process controlling balance, neuronal action potential, phototransduction, signal transduction; MF: G protein-coupled photoreceptor activity, G protein-coupled receptor activity, beta2-adrenergic receptor activity, cytoskeletal motor activity, transmembrane signaling receptor activity; CC: cell projection, ciliary membrane, cilium, cytoplasm, membrane, nucleus, plasma membrane
Pathways:
UniProt: Q9EPB7
Entrez ID: 64378
|
Does Knockout of Lrfn4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Lrfn4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Lrfn4 (leucine rich repeat and fibronectin type III domain containing 4)
Type: protein-coding
Summary: Involved in regulation of postsynaptic density assembly; regulation of presynapse assembly; and synaptic membrane adhesion. Located in cell surface. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; liver; primary head vein; reproductive system; and sensory organ. Orthologous to human LRFN4 (leucine rich repeat and fibronectin type III domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of postsynaptic density assembly, regulation of presynapse assembly, synaptic membrane adhesion; CC: GABA-ergic synapse, cell surface, glutamatergic synapse, membrane, postsynaptic density membrane
Pathways: Neuronal System, Protein-protein interactions at synapses, Synaptic adhesion-like molecules
UniProt: Q80XU8
Entrez ID: 225875
|
Does Knockout of Hnrnpl in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Hnrnpl
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hnrnpl (heterogeneous nuclear ribonucleoprotein L)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to amino acid starvation, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of mRNA splicing, via spliceosome, positive regulation of translation, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA 3'-UTR binding, mRNA CDS binding, mRNA binding, nucleic acid binding, pre-mRNA intronic binding, protein binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus, perinuclear region of cytoplasm, pronucleus, ribonucleoprotein complex, ribonucleoprotein granule, synapse
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8R081
Entrez ID: 15388
|
Does Knockout of Rp1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Rp1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rp1 (retinitis pigmentosa 1 (human))
Type: protein-coding
Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jun 2019].
Gene Ontology: BP: axoneme assembly, cell projection organization, cellular response to light stimulus, intracellular signal transduction, microtubule polymerization, negative regulation of microtubule depolymerization, photoreceptor cell development, photoreceptor cell maintenance, photoreceptor cell outer segment organization, positive regulation of non-motile cilium assembly, response to light stimulus, retina development in camera-type eye, retina morphogenesis in camera-type eye, retinal cone cell development, retinal rod cell development, visual perception; CC: axoneme, cell projection, ciliary tip, cilium, cytoplasm, cytoskeleton, microtubule associated complex, photoreceptor cell cilium, photoreceptor connecting cilium, photoreceptor inner segment, photoreceptor outer segment
Pathways:
UniProt: P56716
Entrez ID: 19888
|
Does Knockout of Dzip1l in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Dzip1l
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dzip1l (DAZ interacting protein 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ciliary transition zone assembly, cilium assembly, floor plate development, neural tube patterning, protein localization to cilium, regulation of protein localization, smoothened signaling pathway; MF: metal ion binding, protein binding, zinc ion binding; CC: axoneme, cell projection, centriole, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, intercellular bridge, microtubule cytoskeleton, mitotic spindle, nucleoplasm
Pathways:
UniProt: Q499E4
Entrez ID: 72507
|
Does Knockout of Gusb in Microglial Cell Line causally result in protein/peptide distribution?
| 1
| 1,585
|
Knockout
|
Gusb
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Gusb (glucuronidase, beta)
Type: protein-coding
Summary: Enables beta-glucuronidase activity. Involved in chondroitin sulfate proteoglycan catabolic process; heparan sulfate proteoglycan catabolic process; and hyaluronan catabolic process. Acts upstream of or within carbohydrate metabolic process. Located in extracellular space. Is active in lysosomal lumen. Is expressed in several structures, including alimentary system; brain; heart; sensory organ; and viscerocranium. Used to study mucopolysaccharidosis type VII. Human ortholog(s) of this gene implicated in mucopolysaccharidosis type VII. Orthologous to human GUSB (glucuronidase beta). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: TORC1 signaling, aorta development, articular cartilage development, autophagy, bone development, bone growth, bone morphogenesis, bone resorption, canonical NF-kappaB signal transduction, carbohydrate metabolic process, cell population proliferation, chondrocyte hypertrophy, chondroitin sulfate proteoglycan catabolic process, cranial skeletal system development, endochondral ossification, energy homeostasis, gene expression, growth plate cartilage development, growth plate cartilage morphogenesis, heparan sulfate proteoglycan catabolic process, homeostasis of number of cells, hyaluronan catabolic process, in utero embryonic development, inflammatory response, lysosome organization, multicellular organism growth, muscle system process, ossification, phosphatidylinositol-3-phosphate biosynthetic process, protein catabolic process, protein localization to nucleus, protein secretion, response to peptide hormone, retinoid metabolic process, skeletal system development, toll-like receptor 4 signaling pathway, tumor necrosis factor-mediated signaling pathway; MF: beta-glucuronidase activity, carbohydrate binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, protein domain specific binding, signaling receptor binding; CC: endoplasmic reticulum, extracellular space, lysosomal lumen, lysosome
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), CS/DS degradation, Chondroitin sulfate/dermatan sulfate metabolism, Drug metabolism - other enzymes - Mus musculus (mouse), Glycosaminoglycan degradation - Mus musculus (mouse), Glycosaminoglycan metabolism, Hyaluronan degradation, Hyaluronan metabolism, Immune System, Innate Immune System, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Pentose and glucuronate interconversions - Mus musculus (mouse), Porphyrin and chlorophyll metabolism - Mus musculus (mouse)
UniProt: P12265
Entrez ID: 110006
|
Does Knockout of Mcidas in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Mcidas
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mcidas (multiciliate differentiation and DNA synthesis associated cell cycle protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, centriole assembly, cilium assembly, motile cilium assembly, multi-ciliated epithelial cell differentiation, negative regulation of cell cycle, positive regulation of transcription by RNA polymerase II, regulation of DNA replication, regulation of DNA-templated DNA replication initiation, regulation of cilium assembly, regulation of mitotic cell cycle, seminiferous tubule development, single fertilization, spermatogenesis; MF: identical protein binding; CC: nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q3UZ45
Entrez ID: 622408
|
Does Knockout of Mus81 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mus81
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mus81 (MUS81 structure-specific endonuclease subunit)
Type: protein-coding
Summary: Predicted to enable 3'-flap endonuclease activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process; mitotic intra-S DNA damage checkpoint signaling; and osteoblast proliferation. Predicted to act upstream of or within DNA catabolic process and response to intra-S DNA damage checkpoint signaling. Predicted to be located in nuclear replication fork. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus and replication fork. Used to study Marfan syndrome; arterial tortuosity syndrome; and pulmonary emphysema. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA catabolic process, DNA damage response, DNA recombination, DNA repair, double-strand break repair, double-strand break repair via break-induced replication, mitotic intra-S DNA damage checkpoint signaling, osteoblast proliferation, replication fork processing, resolution of meiotic recombination intermediates, resolution of mitotic recombination intermediates, response to intra-S DNA damage checkpoint signaling, telomere maintenance; MF: 3'-flap endonuclease activity, DNA binding, DNA endonuclease activity, DNA endonuclease activity, producing 3'-phosphomonoesters, crossover junction DNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity; CC: Holliday junction resolvase complex, chromosome, telomeric region, endodeoxyribonuclease complex, nuclear replication fork, nucleolus, nucleus, replication fork
Pathways: DNA Double-Strand Break Repair, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q91ZJ0
Entrez ID: 71711
|
Does Knockout of Poc1a in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Poc1a
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Poc1a (POC1 centriolar protein A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone development, cell projection organization, cilium assembly, growth plate cartilage chondrocyte development, mitotic spindle organization, non-motile cilium assembly, positive regulation of centrosome duplication, spermatogenesis; CC: cell projection, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, spindle pole
Pathways:
UniProt: Q8JZX3
Entrez ID: 70235
|
Does Knockout of Mfn2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mfn2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mfn2 (mitofusin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, apoptotic process, autophagy, blastocyst formation, camera-type eye morphogenesis, intracellular distribution of mitochondria, mitochondrial calcium ion homeostasis, mitochondrial fusion, mitochondrial membrane organization, mitochondrion localization, mitochondrion organization, negative regulation of Ras protein signal transduction, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell cycle, negative regulation of cell population proliferation, negative regulation of cell size, negative regulation of glial cell proliferation, negative regulation of mitochondrial fission, negative regulation of reactive oxygen species biosynthetic process, negative regulation of release of cytochrome c from mitochondria, negative regulation of sarcomere organization, negative regulation of smooth muscle cell proliferation, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of D-glucose import, positive regulation of cellular respiration, positive regulation of cold-induced thermogenesis, positive regulation of dendritic spine morphogenesis, positive regulation of estradiol secretion, positive regulation of gene expression, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of insulin receptor signaling pathway, positive regulation of mitochondrial membrane potential, positive regulation of ovarian follicle development, positive regulation of progesterone secretion, positive regulation of reactive oxygen species biosynthetic process, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular associated smooth muscle cell proliferation, protein localization to phagophore assembly site, protein targeting to mitochondrion, response to unfolded protein, type 2 mitophagy; MF: GTP binding, GTPase activity, GTPase binding, hydrolase activity, identical protein binding, nucleotide binding, protein binding, proteoglycan binding, small GTPase binding, ubiquitin protein ligase binding; CC: cytosol, membrane, microtubule cytoskeleton, mitochondrial outer membrane, mitochondrion
Pathways: Autophagy, Factors involved in megakaryocyte development and platelet production, Hemostasis, Macroautophagy, Miro GTPase Cycle, Mitophagy, Mitophagy - animal - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), PINK1-PRKN Mediated Mitophagy, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RHOT2 GTPase cycle, Selective autophagy, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q80U63
Entrez ID: 170731
|
Does Knockout of Smim14 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Smim14
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Smim14 (small integral membrane protein 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q91VT8
Entrez ID: 68552
|
Does Knockout of Itga2b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Itga2b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Itga2b (integrin alpha 2b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell adhesion, cell-cell adhesion, cell-matrix adhesion, integrin-mediated signaling pathway, positive regulation of leukocyte migration; MF: extracellular matrix binding, fibrinogen binding, identical protein binding, metal ion binding, molecular adaptor activity, signaling receptor activity; CC: cell surface, external side of plasma membrane, extracellular exosome, focal adhesion, integrin alphaIIb-beta3 complex, integrin complex, membrane, plasma membrane
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Axon guidance, Developmental Biology, Dilated cardiomyopathy - Mus musculus (mouse), ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), GRB2:SOS provides linkage to MAPK signaling for Integrins , Hematopoietic cell lineage - Mus musculus (mouse), Hemostasis, Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Integrin cell surface interactions, Integrin signaling, L1CAM interactions, MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Nervous system development, Neutrophil extracellular trap formation - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet Aggregation (Plug Formation), Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Response to elevated platelet cytosolic Ca2+, Signal Transduction, Signal transduction by L1, Small cell lung cancer - Mus musculus (mouse), p130Cas linkage to MAPK signaling for integrins
UniProt: Q9QUM0
Entrez ID: 16399
|
Does Knockout of Cabin1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Cabin1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cabin1 (calcineurin binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of apoptotic process, nucleosome assembly, signal transduction; MF: nucleosome binding, protein domain specific binding, protein phosphatase 2B binding, protein phosphatase inhibitor activity; CC: aggresome, cytosol, nucleoplasm, nucleus
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, DNA Damage/Telomere Stress Induced Senescence, Formation of Senescence-Associated Heterochromatin Foci (SAHF)
UniProt: Q6PFH4, G3X8Q1, Q80X22, A0A1W2P8C4, A0A1W2P819, A0A1W2P755, A0A1W2P8A1, A0A1W2P6X4
Entrez ID: 104248
|
Does Knockout of Psmc4 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Psmc4
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Psmc4 (proteasome (prosome, macropain) 26S subunit, ATPase, 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATP binding, ATP hydrolysis activity, nucleotide binding, proteasome-activating activity; CC: ciliary basal body, cytoplasm, cytosol, cytosolic proteasome complex, inclusion body, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P54775
Entrez ID: 23996
|
Does Knockout of Rfx2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Rfx2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rfx2 (regulatory factor X, 2 (influences HLA class II expression))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acrosome assembly, cell differentiation, cell projection organization, cellular response to leukemia inhibitory factor, cilium assembly, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatid development, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleus
Pathways:
UniProt: P48379
Entrez ID: 19725
|
Does Knockout of Traf3 in Malignant Peripheral Nerve Sheath Tumor (MPNST) cancer cell causally result in tumorigenicity?
| 1
| 2,184
|
Knockout
|
Traf3
|
tumorigenicity
|
Malignant Peripheral Nerve Sheath Tumor (MPNST) cancer cell
|
Gene: Traf3 (TNF receptor-associated factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Toll signaling pathway, antiviral innate immune response, apoptotic process, cell surface receptor signaling pathway, immune system process, innate immune response, mRNA transcription, negative regulation of NF-kappaB transcription factor activity, positive regulation of type I interferon production, regulation of apoptotic process, regulation of canonical NF-kappaB signal transduction, regulation of cytokine production, regulation of defense response to virus, regulation of interferon-beta production, regulation of proteolysis, regulation of type I interferon production, signal transduction, toll-like receptor 4 signaling pathway, toll-like receptor signaling pathway, tumor necrosis factor-mediated signaling pathway; MF: enzyme binding, identical protein binding, metal ion binding, protein binding, protein kinase binding, protein phosphatase binding, signaling adaptor activity, thioesterase binding, transferase activity, tumor necrosis factor receptor binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: CD40 receptor complex, cytoplasm, cytoplasmic side of plasma membrane, endosome, endosome membrane, mitochondrion
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Alcoholic liver disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Deubiquitination, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, MyD88-independent TLR4 cascade , NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Ovarian tumor domain proteases, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Small cell lung cancer - Mus musculus (mouse), TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNF signaling pathway - Mus musculus (mouse), TNFR2 non-canonical NF-kB pathway, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q60803
Entrez ID: 22031
|
Does Knockout of Rgs19 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Rgs19
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rgs19 (regulator of G-protein signaling 19)
Type: protein-coding
Summary: Predicted to enable G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Predicted to be located in brush border and clathrin-coated vesicle. Is expressed in embryo; forelimb bud; palatal shelf epithelium; and primary palate epithelium. Orthologous to human RGS19 (regulator of G protein signaling 19). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, negative regulation of signal transduction; MF: G-protein alpha-subunit binding, protein binding; CC: brush border, clathrin-coated vesicle, membrane
Pathways: G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: Q9CX84
Entrez ID: 56470
|
Does Knockout of Lrfn2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Lrfn2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lrfn2 (leucine rich repeat and fibronectin type III domain containing 2)
Type: protein-coding
Summary: Involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Located in cell surface. Is active in Schaffer collateral - CA1 synapse; postsynapse; and presynapse. Is expressed in several structures, including central nervous system; esophagus; eye; male reproductive gland or organ; and trigeminal nerve. Used to study autism spectrum disorder. Orthologous to human LRFN2 (leucine rich repeat and fibronectin type III domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: modulation of chemical synaptic transmission, regulation of postsynapse organization; CC: Schaffer collateral - CA1 synapse, cell surface, membrane, plasma membrane, postsynapse, postsynaptic density membrane, postsynaptic membrane, presynapse, synapse
Pathways: Neuronal System, Protein-protein interactions at synapses, Synaptic adhesion-like molecules
UniProt: Q80TG9
Entrez ID: 70530
|
Does Knockout of Gm2a in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Gm2a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gm2a (GM2 ganglioside activator protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ganglioside catabolic process, ganglioside metabolic process, glycosphingolipid catabolic process, learning or memory, lipid metabolic process, lipid storage, lipid transport, nervous system process, neuromuscular process controlling balance, oligosaccharide catabolic process, sphingolipid metabolic process; MF: beta-N-acetylgalactosaminidase activity, beta-N-acetylhexosaminidase activity, enzyme activator activity, hydrolase activity, lipid transporter activity, phospholipase activator activity; CC: apical plasma membrane, basolateral plasma membrane, cytoplasmic side of plasma membrane, cytosol, lysosome, mitochondrion
Pathways: Glycosphingolipid catabolism, Glycosphingolipid metabolism, Immune System, Innate Immune System, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of lipids, Neutrophil degranulation, Sphingolipid metabolism
UniProt: Q60648
Entrez ID: 14667
|
Does Knockout of Zfp456 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Zfp456
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp456 (zinc finger protein 456)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: F2Z406, B2RUK9, A0A286YCV7
Entrez ID: 408065
|
Does Knockout of Rpl12 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Rpl12
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rpl12 (ribosomal protein L12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, large ribosomal subunit rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleolus, nucleus, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P35979
Entrez ID: 269261
|
Does Knockout of Zfp949 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Zfp949
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zfp949 (zinc finger protein 949)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: B2RU83, E9Q732, Q9CUP6, E0CY31
Entrez ID: 71640
|
Does Knockout of Cd300ld4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Cd300ld4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cd300ld4 (CD300 molecule like family member D4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, immune response-activating signaling pathway, immune system process; MF: molecular_function, transmembrane signaling receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: A2A7W1
Entrez ID: 100043123
|
Does Knockout of Tinf2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Tinf2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tinf2 (Terf1 (TRF1)-interacting nuclear factor 2)
Type: protein-coding
Summary: Enables telomeric DNA binding activity. Acts upstream of or within negative regulation of telomere maintenance. Located in chromosome, telomeric region. Is expressed in several structures, including genitourinary system; midbrain ventricular layer; olfactory epithelium; telencephalon; and thymus primordium. Used to study dyskeratosis congenita. Human ortholog(s) of this gene implicated in Revesz syndrome and autosomal dominant dyskeratosis congenita 3. Orthologous to human TINF2 (TERF1 interacting nuclear factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of epithelial cell proliferation, negative regulation of telomere maintenance, negative regulation of telomere maintenance via telomerase, positive regulation of telomere maintenance, protein localization to chromosome, telomeric region, regulation of telomere maintenance via telomere lengthening, telomere assembly, telomere capping; MF: protein binding, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, nuclear body, nuclear telomere cap complex, nucleoplasm, nucleus, perinucleolar chromocenter, shelterin complex
Pathways:
UniProt: A0A2I3BRL3, Q8K1K3, A0A2I3BRI7, A0A2I3BRW2, A0A2I3BPS4
Entrez ID: 28113
|
Does Knockout of Tsga13 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Tsga13
|
cell cycle progression
|
breast epithelium
|
Gene: Tsga13 (testis specific gene A13)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DA17
Entrez ID: 116732
|
Does Knockout of Rhox2h in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Rhox2h
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rhox2h (reproductive homeobox 2H)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: V9GXS0, K7N6P1
Entrez ID: 622301
|
Does Knockout of Rcc2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Rcc2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Rcc2 (regulator of chromosome condensation 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of GTPase activity, cell division, chromosome passenger complex localization to kinetochore, establishment of protein localization, focal adhesion assembly, integrin-mediated signaling pathway, negative regulation of GTPase activity, negative regulation of focal adhesion assembly, negative regulation of substrate adhesion-dependent cell spreading, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of attachment of spindle microtubules to kinetochore, regulation of cell migration, regulation of fibroblast migration, regulation of ruffle assembly; MF: guanyl-nucleotide exchange factor activity, microtubule binding, protein domain specific binding, protein kinase binding, small GTPase binding; CC: chromosome, chromosome, centromeric core domain, chromosome, centromeric region, cytoplasm, cytoskeleton, early endosome membrane, membrane, microtubule, midbody, mitotic spindle midzone, nucleolus, nucleus, plasma membrane, spindle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BK67
Entrez ID: 108911
|
Does Knockout of Dlgap3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Dlgap3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dlgap3 (DLG associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: modification of postsynaptic structure, modulation of chemical synaptic transmission, protein-containing complex assembly, signaling; MF: PDZ domain binding, amyloid-beta binding, molecular adaptor activity, protein domain specific binding, scaffold protein binding; CC: cholinergic synapse, dendritic spine, glutamatergic synapse, membrane, neuromuscular junction, neuronal cell body, plasma membrane, postsynaptic density, postsynaptic specialization, synapse
Pathways: Neurexins and neuroligins, Neuronal System, Protein-protein interactions at synapses
UniProt: Q6PFD5
Entrez ID: 242667
|
Does Knockout of Dmap1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Dmap1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dmap1 (DNA methyltransferase 1-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of protein import into nucleus, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, response to ethanol; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, transcription corepressor activity; CC: NuA4 histone acetyltransferase complex, Swr1 complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleosome, nucleus, replication fork
Pathways:
UniProt: Q9JI44
Entrez ID: 66233
|
Does Knockout of Pam16 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Pam16
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pam16 (presequence translocase-asssociated motor 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, negative regulation of apoptotic signaling pathway, ossification, protein import into mitochondrial matrix, protein transport; CC: PAM complex, Tim23 associated import motor, TIM23 mitochondrial import inner membrane translocase complex, cytoplasm, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CQV1
Entrez ID: 66449
|
Does Knockout of Ankrd33 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Ankrd33
|
response to virus
|
Microglial Cell Line
|
Gene: Ankrd33 (ankyrin repeat domain 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, skeletal muscle cell differentiation; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8BXP5
Entrez ID: 208258
|
Does Knockout of Cad in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Cad
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cad (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' UMP biosynthetic process, 'de novo' pyrimidine nucleobase biosynthetic process, UDP biosynthetic process, UTP biosynthetic process, amino acid metabolic process, animal organ regeneration, cellular response to epidermal growth factor stimulus, cellular response to xenobiotic stimulus, citrulline biosynthetic process, female pregnancy, glutamine metabolic process, heart development, lactation, liver development, nucleobase-containing small molecule metabolic process, phosphate-containing compound metabolic process, pyrimidine nucleotide biosynthetic process, pyrimidine-containing compound biosynthetic process, response to amine, response to caffeine, response to cortisol, response to insulin, response to starvation, response to testosterone, xenobiotic metabolic process; MF: ATP binding, UTP binding, amino acid binding, aspartate carbamoyltransferase activity, carbamoyl-phosphate synthase (ammonia) activity, carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, carboxyl- or carbamoyltransferase activity, catalytic activity, dihydroorotase activity, enzyme binding, glutaminase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, identical protein binding, ligase activity, metal ion binding, nucleotide binding, protein kinase activity, transferase activity, zinc ion binding; CC: cell projection, cytoplasm, cytosol, neuronal cell body, nuclear matrix, nucleus, protein-containing complex, terminal bouton
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Pyrimidine biosynthesis, Pyrimidine metabolism - Mus musculus (mouse), pyrimidine ribonucleotides <i>de novo</i> biosynthesis, uridine-5,-phosphate biosynthesis
UniProt: B2RQC6
Entrez ID: 69719
|
Does Knockout of Orc3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Orc3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Orc3 (origin recognition complex, subunit 3)
Type: protein-coding
Summary: Predicted to enable DNA replication origin binding activity. Acts upstream of or within glial cell proliferation and neural precursor cell proliferation. Predicted to be located in chromatin and nuclear body. Predicted to be part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Orthologous to human ORC3 (origin recognition complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA replication, DNA replication initiation, glial cell proliferation, neural precursor cell proliferation, regulation of DNA replication; MF: DNA binding, DNA replication origin binding; CC: DNA replication preinitiation complex, chromatin, chromosome, nuclear body, nuclear origin of replication recognition complex, nuclear pre-replicative complex, nucleoplasm, nucleus, origin recognition complex
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the ORC complex at the origin of replication, Assembly of the pre-replicative complex, CDC6 association with the ORC:origin complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: Q9JK30
Entrez ID: 50793
|
Does Knockout of Gnai2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Gnai2
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Gnai2 (G protein subunit alpha i2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled acetylcholine receptor signaling pathway, G protein-coupled adenosine receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell division, cell population proliferation, gamma-aminobutyric acid signaling pathway, modulation of chemical synaptic transmission, negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway, negative regulation of apoptotic signaling pathway, negative regulation of calcium ion-dependent exocytosis, negative regulation of synaptic transmission, positive regulation of ERK1 and ERK2 cascade, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of neural precursor cell proliferation, positive regulation of superoxide anion generation, positive regulation of urine volume, positive regulation of vascular associated smooth muscle cell proliferation, regulation of calcium ion transport, signal transduction; MF: G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, guanyl nucleotide binding, metal ion binding, nucleotide binding, protein binding; CC: cell body, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, dendrite, heterotrimeric G-protein complex, hippocampal mossy fiber to CA3 synapse, membrane, midbody, neuronal dense core vesicle, nucleoplasm, plasma membrane
Pathways: ADP signalling through P2Y purinoceptor 12, Activation of GABAB receptors, Adenylate cyclase inhibitory pathway, Adrenaline,noradrenaline inhibits insulin secretion, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Axon guidance - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), ESR-mediated signaling, Estrogen signaling pathway - Mus musculus (mouse), Extra-nuclear estrogen signaling, G alpha (i) signalling events, G-protein mediated events, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Mus musculus (mouse), GPCR downstream signalling, Gap junction - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hemostasis, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Integration of energy metabolism, Leukocyte transendothelial migration - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Metabolism, Morphine addiction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, Oxytocin signaling pathway - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Regulation of insulin secretion, Regulation of lipolysis in adipocytes - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Sphingolipid signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Transmission across Chemical Synapses, cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), cyclic AMP biosynthesis
UniProt: P08752
Entrez ID: 14678
|
Does Knockout of Serpinb8 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Serpinb8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Serpinb8 (serine (or cysteine) peptidase inhibitor, clade B, member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial cell-cell adhesion; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: cytoplasm, cytosol, extracellular space
Pathways: Dissolution of Fibrin Clot, Hemostasis
UniProt: O08800
Entrez ID: 20725
|
Does Knockout of Dpysl5 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Dpysl5
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Dpysl5 (dihydropyrimidinase-like 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, negative regulation of dendrite morphogenesis, neuron differentiation, pyrimidine nucleobase catabolic process; MF: dihydropyrimidinase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, protein binding; CC: cytoplasm, cytosol, dendrite, glutamatergic synapse, neuronal cell body, protein-containing complex, synapse
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), CRMPs in Sema3A signaling, Developmental Biology, Nervous system development, Semaphorin interactions
UniProt: Q9EQF6
Entrez ID: 65254
|
Does Knockout of Ankmy2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Ankmy2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ankmy2 (ankyrin repeat and MYND domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: enzyme binding, metal ion binding, zinc ion binding; CC: cell projection, cellular_component, cilium
Pathways:
UniProt: Q3TPE9
Entrez ID: 217473
|
Does Knockout of Cox11 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Cox11
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cox11 (cytochrome c oxidase assembly protein 11, copper chaperone)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP biosynthetic process, intracellular monoatomic cation homeostasis; MF: copper ion binding, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, protein-containing complex
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Oxidative phosphorylation - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: Q6P8I6
Entrez ID: 69802
|
Does Knockout of Sema4g in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Sema4g
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Sema4g (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell differentiation, negative chemotaxis, nervous system development, neural crest cell migration, positive regulation of cell migration, semaphorin-plexin signaling pathway; MF: chemorepellent activity, neuropilin binding, protein binding, semaphorin receptor binding; CC: membrane, plasma membrane
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q9WUH7
Entrez ID: 26456
|
Does Knockout of Rundc3a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Rundc3a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rundc3a (RUN domain containing 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cGMP-mediated signaling
Pathways:
UniProt: O08576
Entrez ID: 51799
|
Does Knockout of Rnf44 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Rnf44
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rnf44 (ring finger protein 44)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: Q3UHJ8
Entrez ID: 105239
|
Does Knockout of Ccdc169 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Ccdc169
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccdc169 (coiled-coil domain containing 169)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BXX9
Entrez ID: 320604
|
Does Knockout of Uqcr10 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Uqcr10
|
cell cycle progression
|
breast epithelium
|
Gene: Uqcr10 (ubiquinol-cytochrome c reductase, complex III subunit X)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex III assembly, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q8R1I1
Entrez ID: 66152
|
Does Knockout of Serpinb12 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Serpinb12
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Serpinb12 (serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: cornified envelope, cytoplasm, extracellular space
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q9D7P9
Entrez ID: 71869
|
Does Knockout of Adra1a in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Adra1a
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Adra1a (adrenergic receptor, alpha 1a)
Type: protein-coding
Summary: This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating adrenergic receptor signaling pathway, adrenergic receptor signaling pathway, adult heart development, cell growth involved in cardiac muscle cell development, cell-cell signaling, negative regulation of Rho protein signal transduction, negative regulation of autophagy, negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure, neuron-glial cell signaling, norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure, organ growth, phospholipase C-activating G protein-coupled receptor signaling pathway, phospholipase C-activating adrenergic receptor signaling pathway, pilomotor reflex, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of action potential, positive regulation of cardiac muscle contraction, positive regulation of cardiac muscle hypertrophy, positive regulation of cytosolic calcium ion concentration, positive regulation of heart rate, positive regulation of heart rate by epinephrine-norepinephrine, positive regulation of phospholipase C/protein kinase C signal transduction, positive regulation of smooth muscle contraction, positive regulation of synaptic transmission, GABAergic, positive regulation of systemic arterial blood pressure, positive regulation of the force of heart contraction by epinephrine-norepinephrine, positive regulation of vasoconstriction, presynaptic modulation of chemical synaptic transmission, regulation of blood pressure, regulation of cardiac muscle contraction, regulation of muscle contraction, regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback, regulation of vasoconstriction, response to hormone, response to xenobiotic stimulus, signal transduction, vasoconstriction; MF: G protein-coupled receptor activity, adrenergic receptor activity, alpha1-adrenergic receptor activity, protein heterodimerization activity; CC: GABA-ergic synapse, T-tubule, Z disc, caveola, cytoplasm, cytosol, dopaminergic synapse, glutamatergic synapse, membrane, nuclear membrane, nucleoplasm, nucleus, plasma membrane, postsynaptic membrane, presynaptic membrane
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Adrenoceptors, Amine ligand-binding receptors, Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (12/13) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P97718
Entrez ID: 11549
|
Does Knockout of Cdc20 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Cdc20
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cdc20 (cell division cycle 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, anaphase-promoting complex-dependent catabolic process, cell differentiation, cell division, metaphase/anaphase transition of cell cycle, metaphase/anaphase transition of meiosis I, mitotic sister chromatid cohesion, mitotic spindle assembly, mitotic spindle assembly checkpoint signaling, nervous system development, positive regulation of anaphase-promoting complex-dependent catabolic process, positive regulation of cell population proliferation, positive regulation of mitotic metaphase/anaphase transition, positive regulation of synapse maturation, positive regulation of synaptic plasticity, positive regulation of ubiquitin protein ligase activity, protein deubiquitination, protein ubiquitination, regulation of dendrite development, regulation of meiotic nuclear division; MF: anaphase-promoting complex binding, histone deacetylase binding, protein binding, ubiquitin ligase activator activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activator activity; CC: anaphase-promoting complex, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, mitotic checkpoint complex, nucleoplasm, perinuclear region of cytoplasm, protein-containing complex, spindle pole
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Antigen processing: Ubiquitination & Proteasome degradation, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Deubiquitination, EML4 and NUDC in mitotic spindle formation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of Emi1, Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, Resolution of Sister Chromatid Cohesion, SCF-beta-TrCP mediated degradation of Emi1, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q9JJ66
Entrez ID: 107995
|
Does Knockout of Pick1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Pick1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pick1 (protein interacting with C kinase 1)
Type: protein-coding
Summary: Enables protein kinase C binding activity and signaling receptor binding activity. Involved in receptor clustering. Acts upstream of or within protein targeting. Located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and postsynaptic density. Is expressed in brain; cerebellum Purkinje cell layer; cerebellum molecular layer; cerebral cortex ventricular layer; and cortical plate. Orthologous to human PICK1 (protein interacting with PRKCA 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to decreased oxygen levels, cellular response to glucose starvation, dendritic spine maintenance, dendritic spine organization, glial cell development, intracellular protein transport, intracellular signal transduction, long-term synaptic depression, monoamine transport, negative regulation of Arp2/3 complex-mediated actin nucleation, negative regulation of gene expression, positive regulation of receptor internalization, protein phosphorylation, protein targeting, receptor clustering, regulation of Arp2/3 complex-mediated actin nucleation, regulation of insulin secretion, regulation of postsynaptic neurotransmitter receptor internalization, regulation of synapse structure or activity; MF: Arp2/3 complex binding, G protein-coupled glutamate receptor binding, G protein-coupled receptor binding, SNAP receptor activity, actin binding, actin filament binding, cytoskeletal protein binding, identical protein binding, ionotropic glutamate receptor binding, membrane curvature sensor activity, metal ion binding, phospholipid binding, protein binding, protein domain specific binding, protein kinase C binding, signaling receptor binding; CC: Golgi apparatus, cytoplasm, cytoskeleton, cytosol, dendrite, dendritic spine, excitatory synapse, glutamatergic synapse, membrane, mitochondrion, neuron projection, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, postsynaptic endocytic zone, postsynaptic specialization, presynaptic membrane, protein-containing complex, synapse, synaptic vesicle, trans-Golgi network membrane
Pathways:
UniProt: Q8C1W2, E9PUZ5
Entrez ID: 18693
|
Does Knockout of Zfp131 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Zfp131
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zfp131 (zinc finger protein 131)
Type: protein-coding
Summary: This gene encodes a member of the BTB/POZ family of transcription factors. This protein has been found to act as a transcriptional activator and may regulate estrogen receptor signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: intermediate filament cytoskeleton, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors
UniProt: Q8K3J5
Entrez ID: 72465
|
Does Knockout of Tex19.1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Tex19.1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tex19.1 (testis expressed gene 19.1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell proliferation involved in embryonic placenta development, homologous chromosome pairing at meiosis, in utero embryonic development, male gonad development, male meiotic nuclear division, meiotic cell cycle, placenta development, post-transcriptional regulation of gene expression, reciprocal meiotic recombination, spermatogenesis, spongiotrophoblast cell proliferation, transposable element silencing; MF: RNA binding, piRNA binding, protein binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q99MV2
Entrez ID: 73679
|
Does Knockout of Crybb2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Crybb2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Crybb2 (crystallin, beta B2)
Type: protein-coding
Summary: This gene is a member of the beta-crystallin family. Beta crystallins, along with alpha and gamma crystallins, are the major proteins found in the eye lens. These proteins maintain the refractive index of the lens whilst also maintaining its transparency. Since lens central fiber cells lose their nuclei during development, crystallins are made and then retained throughout life, making them extremely stable proteins. Beta and gamma crystallins are considered be a superfamily and have a similar domain architecture, including four Greek Key motifs. Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. The protein encoded by this gene may have Ca2+-binding activity and could be associated with potential functions in the hippocampus and in sperm. Targeted knockout of this gene in mouse induces age-related cataract. A chain-terminating mutation in a similar gene in human was found to cause type 2 cerulean cataracts. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: camera-type eye development, eye development, lens development in camera-type eye, visual perception; MF: identical protein binding, structural constituent of eye lens
Pathways:
UniProt: P62696
Entrez ID: 12961
|
Does Knockout of Pex26 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Pex26
|
cell proliferation
|
Regulatory T cell
|
Gene: Pex26 (peroxisomal biogenesis factor 26)
Type: protein-coding
Summary: This gene is a member of the peroxin-26 family. The encoded protein is probably required for protein import into peroxisomes. It may anchor Pex1 and Pex6 to peroxisome membranes. Defects in a similar gene in human are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: protein import into peroxisome matrix, protein import into peroxisome matrix, receptor recycling, protein import into peroxisome membrane, protein to membrane docking, protein transport, protein unfolding; MF: ATPase binding, protein-containing complex binding, protein-membrane adaptor activity; CC: membrane, peroxisomal membrane, peroxisome
Pathways: Class I peroxisomal membrane protein import, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Protein localization
UniProt: Q8BGI5
Entrez ID: 74043
|
Does Knockout of Gstt1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Gstt1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gstt1 (glutathione S-transferase, theta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA modification, cellular oxidant detoxification, dichloromethane metabolic process, glutathione metabolic process, response to salicylic acid, response to selenium ion, response to vitamin E, response to xenobiotic stimulus; MF: alkylhalidase activity, glutathione peroxidase activity, glutathione transferase activity, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug ADME, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Paracetamol ADME, Pathways in cancer - Mus musculus (mouse), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: Q64471
Entrez ID: 14871
|
Does Knockout of Adprhl1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Adprhl1
|
cell cycle progression
|
breast epithelium
|
Gene: Adprhl1 (ADP-ribosylhydrolase like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac chamber ballooning, cardiac myofibril assembly, protein de-ADP-ribosylation; MF: ADP-ribosylarginine hydrolase activity, magnesium ion binding; CC: cytoplasm, sarcomere
Pathways:
UniProt: Q8BGK2
Entrez ID: 234072
|
Does Knockout of Dnaaf5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Dnaaf5
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Dnaaf5 (dynein, axonemal assembly factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium movement, inner dynein arm assembly, outer dynein arm assembly; MF: dynein intermediate chain binding; CC: cytoplasm, cytosol, dynein axonemal particle, microtubule cytoskeleton, mitotic spindle, motile cilium, nucleolus
Pathways:
UniProt: B9EJR8
Entrez ID: 433956
|
Does Knockout of Cbln3 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Cbln3
|
phagocytosis
|
macrophage
|
Gene: Cbln3 (cerebellin 3 precursor protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, endoplasmic reticulum, extracellular region, extracellular space, parallel fiber to Purkinje cell synapse, synapse, synaptic cleft
Pathways:
UniProt: Q9JHG0
Entrez ID: 56410
|
Does Knockout of Gng12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Gng12
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gng12 (guanine nucleotide binding protein (G protein), gamma 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G-protein beta-subunit binding, PDZ domain binding, phosphate ion binding; CC: actin filament, heterotrimeric G-protein complex, membrane, plasma membrane, synapse
Pathways: ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of G protein gated Potassium channels, Activation of GABAB receptors, Activation of kainate receptors upon glutamate binding, Adrenaline,noradrenaline inhibits insulin secretion, Alcoholism - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Aquaporin-mediated transport, Beta-catenin independent WNT signaling, Ca2+ pathway, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chaperonin-mediated protein folding, Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Class B/2 (Secretin family receptors), Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Dopaminergic synapse - Mus musculus (mouse), ESR-mediated signaling, Extra-nuclear estrogen signaling, G alpha (12/13) signalling events, G alpha (i) signalling events, G alpha (q) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G beta:gamma signalling through BTK, G beta:gamma signalling through CDC42, G beta:gamma signalling through PI3Kgamma, G beta:gamma signalling through PLC beta, G protein gated Potassium channels, G-protein activation, G-protein beta:gamma signalling, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Mus musculus (mouse), GPCR downstream signalling, GPCR ligand binding, GPER1 signaling, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Glutamatergic synapse - Mus musculus (mouse), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Integration of energy metabolism, Inwardly rectifying K+ channels, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of proteins, Morphine addiction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet homeostasis, Potassium Channels, Presynaptic function of Kainate receptors, Prostacyclin signalling through prostacyclin receptor, Protein folding, Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of insulin secretion, Relaxin signaling pathway - Mus musculus (mouse), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by WNT, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, Transmission across Chemical Synapses, Transport of small molecules, Vasopressin regulates renal water homeostasis via Aquaporins
UniProt: Q9DAS9
Entrez ID: 14701
|
Does Knockout of Hcfc2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,278
|
Knockout
|
Hcfc2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Hcfc2 (host cell factor C2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, chromatin remodeling, immune response involved in response to exogenous dsRNA, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of toll-like receptor 3 signaling pathway, regulation of transcription by RNA polymerase II; MF: transcription coactivator activity, transcription coregulator activity; CC: MLL1 complex, MLL1/2 complex, Set1C/COMPASS complex, cytoplasm, cytosol, histone methyltransferase complex, nucleoplasm, nucleus, plasma membrane
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q9D968
Entrez ID: 67933
|
Does Knockout of Qpctl in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Qpctl
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Qpctl (glutaminyl-peptide cyclotransferase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acyltransferase activity, glutaminyl-peptide cyclotransferase activity, metal ion binding, transferase activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, membrane
Pathways:
UniProt: Q8BH73
Entrez ID: 67369
|
Does Knockout of Mrpl3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Mrpl3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mrpl3 (mitochondrial ribosomal protein L3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q99N95
Entrez ID: 94062
|
Does Knockout of Rpp21 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Rpp21
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rpp21 (ribonuclease P 21 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, response to xenobiotic stimulus, tRNA 5'-leader removal, tRNA processing; MF: metal ion binding, ribonuclease P RNA binding, ribonuclease P activity; CC: endoribonuclease complex, multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8R040
Entrez ID: 67676
|
Does Knockout of Lrrc63 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Lrrc63
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Lrrc63 (leucine rich repeat containing 63)
Type: protein-coding
Summary: Predicted to be involved in intracellular signal transduction. Orthologous to human LRRC63 (leucine rich repeat containing 63). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A6H694
Entrez ID: 70859
|
Does Knockout of Tln1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Tln1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tln1 (talin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, cell adhesion, cell junction assembly, cell-cell adhesion, cell-substrate junction assembly, cortical actin cytoskeleton organization, cortical microtubule organization, integrin activation, integrin-mediated signaling pathway; MF: LIM domain binding, actin binding, actin filament binding, integrin binding, phosphatidylinositol binding, phosphatidylserine binding, protein binding, structural constituent of cytoskeleton, vinculin binding; CC: adherens junction, anchoring junction, cell projection, cell surface, cytoplasm, cytoskeleton, cytosol, focal adhesion, membrane, plasma membrane, ruffle, ruffle membrane
Pathways: Axon guidance, Developmental Biology, Focal adhesion - Mus musculus (mouse), GRB2:SOS provides linkage to MAPK signaling for Integrins , Hemostasis, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Integrin signaling, MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Muscle contraction, Nervous system development, Platelet Aggregation (Plug Formation), Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Response to elevated platelet cytosolic Ca2+, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, Semaphorin interactions, Signal Transduction, Smooth Muscle Contraction, p130Cas linkage to MAPK signaling for integrins
UniProt: P26039
Entrez ID: 21894
|
Does Knockout of Fcho1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Fcho1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Fcho1 (FCH domain only 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, clathrin coat assembly, clathrin-dependent endocytosis, endocytosis, positive regulation of T cell activation; MF: AP-2 adaptor complex binding, protein binding; CC: clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytosol, membrane, nucleoplasm, plasma membrane, postsynaptic endocytic zone
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q8K285
Entrez ID: 74015
|
Does Knockout of Rnase6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Rnase6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rnase6 (ribonuclease, RNase A family, 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, defense response to virus, innate immune response; MF: RNA nuclease activity, endonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding; CC: cytoplasmic vesicle, extracellular region, extracellular space, lysosome
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: Q9D244
Entrez ID: 78416
|
Does Knockout of Dnajc18 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Dnajc18
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dnajc18 (DnaJ heat shock protein family (Hsp40) member C18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to misfolded protein, protein folding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9CZJ9
Entrez ID: 76594
|
Does Knockout of Stt3a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Stt3a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Stt3a (STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: post-translational protein modification, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; MF: dolichyl-diphosphooligosaccharide-protein glycotransferase activity, glycosyltransferase activity, metal ion binding, oligosaccharyl transferase activity, protein kinase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, N-Glycan biosynthesis - Mus musculus (mouse), PD-L1(CD274) glycosylation and translocation to plasma membrane, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: P46978
Entrez ID: 16430
|
Does Knockout of Tekt2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Tekt2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tekt2 (tektin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, cilium movement involved in cell motility, flagellated sperm motility, inner dynein arm assembly; CC: axonemal A tubule inner sheath, axonemal microtubule, cell projection, cilium, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, microtubule organizing center, motile cilium, sperm flagellum
Pathways:
UniProt: Q922G7
Entrez ID: 24084
|
Does Knockout of Liph in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Liph
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Liph (lipase, member H)
Type: protein-coding
Summary: Predicted to enable heparin binding activity and phospholipase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including anal canal; epidermis; genitourinary system; gut; and hippocampus. Human ortholog(s) of this gene implicated in hypotrichosis 7. Orthologous to human LIPH (lipase H). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: lipid catabolic process, lipid metabolic process, phosphatidic acid biosynthetic process; MF: carboxylic ester hydrolase activity, heparin binding, hydrolase activity, lipase activity, phospholipase activity; CC: extracellular region, extracellular space, membrane, plasma membrane
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA
UniProt: Q8CIV3
Entrez ID: 239759
|
Does Knockout of Acacb in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Acacb
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Acacb (acetyl-Coenzyme A carboxylase beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import, acetyl-CoA metabolic process, acyl-CoA metabolic process, energy homeostasis, fatty acid biosynthetic process, fatty acid metabolic process, fatty acid oxidation, intracellular aspartate homeostasis, intracellular glutamate homeostasis, lactic acid secretion, lipid metabolic process, malonyl-CoA biosynthetic process, negative regulation of fatty acid beta-oxidation, negative regulation of fatty acid oxidation, negative regulation of fatty acid transport, negative regulation of intracellular lipid transport, negative regulation of lipid catabolic process, negative regulation of transmembrane transport, pentose-phosphate shunt, positive regulation of heart growth, positive regulation of lipid storage, protein homotetramerization, purine nucleotide metabolic process, regulation of cardiac muscle hypertrophy in response to stress, regulation of glucose metabolic process, response to caloric restriction, response to nutrient, response to nutrient levels, response to xenobiotic stimulus, tricarboxylic acid metabolic process; MF: ATP binding, acetyl-CoA carboxylase activity, biotin binding, catalytic activity, identical protein binding, ligase activity, metal ion binding, nucleotide binding; CC: mitochondrial fatty acid beta-oxidation multienzyme complex, mitochondrial outer membrane, mitochondrion, nucleus
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Biotin transport and metabolism, Carnitine shuttle, Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid metabolism, Glucagon signaling pathway - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Propanoate metabolism - Mus musculus (mouse), Pyruvate metabolism - Mus musculus (mouse), biotin-carboxyl carrier protein assembly
UniProt: E9Q4Z2
Entrez ID: 100705
|
Does Knockout of Trip13 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Trip13
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Trip13 (thyroid hormone receptor interactor 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, double-strand break repair, female meiosis I, male meiosis I, meiotic cell cycle, meiotic recombination checkpoint signaling, mitotic spindle assembly checkpoint signaling, oocyte maturation, oogenesis, reciprocal meiotic recombination, spermatid development, spermatogenesis, synaptonemal complex assembly; MF: ATP binding, ATP hydrolysis activity, identical protein binding, nucleotide binding, protein binding; CC: chromosome, male germ cell nucleus, nucleus
Pathways:
UniProt: Q3UA06
Entrez ID: 69716
|
Does Knockout of Nphs1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Nphs1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nphs1 (nephrosis 1, nephrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, MAPK cascade, cell adhesion, cell-cell adhesion, gene expression, glomerular basement membrane development, muscle organ development, myoblast fusion, podocyte development, positive regulation of actin filament polymerization, protein localization to synapse, skeletal muscle tissue development, slit diaphragm assembly; MF: alpha-actinin binding, cell adhesion molecule binding, myosin binding, protein binding, protein domain specific binding, spectrin binding; CC: basement membrane, cell periphery, cell projection, cell-cell junction, focal adhesion, membrane, plasma membrane, protein-containing complex, slit diaphragm
Pathways: Cell-Cell communication, Nephrin family interactions
UniProt: Q9QZS7
Entrez ID: 54631
|
Does Knockout of 1700012B07Rik in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
1700012B07Rik
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: 1700012B07Rik (RIKEN cDNA 1700012B07 gene)
Type: protein-coding
Summary: RIKEN cDNA 1700012B07 gene
Gene Ontology: MF: molecular_function, protein binding
Pathways:
UniProt: Q9DAE9, Q3V0S8, A2AGP8
Entrez ID: 69324
|
Does Knockout of Ilk in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Ilk
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ilk (integrin linked kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell development, anatomical structure morphogenesis, branching involved in ureteric bud morphogenesis, caveola assembly, cell differentiation, cell morphogenesis, cell projection organization, cell-matrix adhesion, establishment or maintenance of epithelial cell apical/basal polarity, fibroblast migration, integrin-mediated signaling pathway, mitotic spindle organization, myelination in peripheral nervous system, negative regulation of apoptotic process, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell population proliferation, negative regulation of neural precursor cell proliferation, negative regulation of neuron apoptotic process, negative regulation of smooth muscle cell migration, negative regulation of smooth muscle cell proliferation, nerve development, neuron projection morphogenesis, outflow tract morphogenesis, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of BMP signaling pathway, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of axon extension, positive regulation of axonogenesis, positive regulation of canonical NF-kappaB signal transduction, positive regulation of canonical Wnt signaling pathway, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cell-matrix adhesion, positive regulation of cellular senescence, positive regulation of dendrite morphogenesis, positive regulation of myoblast differentiation, positive regulation of osteoblast differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of signal transduction, positive regulation of substrate adhesion-dependent cell spreading, protein localization to cell cortex, regulation of actin cytoskeleton organization, regulation of cell growth, substrate adhesion-dependent cell spreading, supramolecular fiber organization, tumor necrosis factor-mediated signaling pathway; MF: ATP binding, SH3 domain binding, integrin binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein domain specific binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein-containing complex binding, protein-macromolecule adaptor activity, signaling receptor binding; CC: actin cytoskeleton, anchoring junction, axon, cell cortex, cell projection, cell-cell junction, centrosome, chromatin, costamere, cytoplasm, cytoskeleton, cytosol, dendritic shaft, focal adhesion, lamellipodium, membrane, neuronal cell body, nucleoplasm, nucleus, plasma membrane, protein-containing complex, sarcomere, stress fiber, terminal bouton
Pathways: Axon guidance - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions, Endometrial cancer - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Localization of the PINCH-ILK-PARVIN complex to focal adhesions, PPAR signaling pathway - Mus musculus (mouse)
UniProt: O55222
Entrez ID: 16202
|
Does Knockout of Ephb1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Ephb1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ephb1 (Eph receptor B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, axon guidance, camera-type eye morphogenesis, cell activation, cell adhesion, cell chemotaxis, cell migration, cell surface receptor protein tyrosine kinase signaling pathway, cell-substrate adhesion, central nervous system projection neuron axonogenesis, cranial nerve development, dendritic spine development, dendritic spine morphogenesis, detection of temperature stimulus involved in sensory perception of pain, ephrin receptor signaling pathway, establishment of cell polarity, hindbrain tangential cell migration, immunological synapse formation, modulation of chemical synaptic transmission, negative regulation of satellite cell differentiation, negative regulation of skeletal muscle satellite cell proliferation, nervous system development, neural precursor cell proliferation, neurogenesis, optic nerve morphogenesis, positive regulation of synapse assembly, protein autophosphorylation, regulation of ERK1 and ERK2 cascade, regulation of JNK cascade, regulation of developmental process, retinal ganglion cell axon guidance, skeletal muscle satellite cell activation; MF: ATP binding, axon guidance receptor activity, ephrin receptor activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, protein-containing complex binding, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity; CC: axon, cell projection, cytoplasm, cytosol, dendrite, early endosome membrane, endoplasmic reticulum, endosome, filopodium tip, glutamatergic synapse, membrane, membrane raft, plasma membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHB-mediated forward signaling, Ephrin signaling, Nervous system development
UniProt: Q8CBF3
Entrez ID: 270190
|
Does Knockout of Tomm40l in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Tomm40l
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Tomm40l (translocase of outer mitochondrial membrane 40-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, protein import into mitochondrial matrix, protein transport, transmembrane transport; MF: mitochondrion targeting sequence binding, porin activity, preprotein binding, protein transmembrane transporter activity; CC: membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion, pore complex, protein-containing complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse)
UniProt: Q9CZR3
Entrez ID: 641376
|
Does Knockout of Sly in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Sly
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Sly (Sycp3 like Y-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A087WRK1, Q810R0, A0A9L6KDV5, A0A087WNQ6
Entrez ID: 382301
|
Does Knockout of 4930451I11Rik in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
4930451I11Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 4930451I11Rik (RIKEN cDNA 4930451I11 gene)
Type: protein-coding
Summary: Involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in extracellular region and plasma membrane. Orthologous to human C16orf92 (chromosome 16 open reading frame 92). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: fertilization, fusion of sperm to egg plasma membrane involved in single fertilization, single fertilization; CC: cellular_component, extracellular region, membrane, plasma membrane
Pathways:
UniProt: E9Q9R3
Entrez ID: 78118
|
Does Knockout of Grwd1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Grwd1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Grwd1 (glutamate-rich WD repeat containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, nucleosome assembly, nucleosome disassembly, ribosome biogenesis; MF: DNA replication origin binding, chromatin binding, histone binding; CC: chromosome, cytosol, nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q810D6
Entrez ID: 101612
|
Does Knockout of Inppl1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Inppl1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Inppl1 (inositol polyphosphate phosphatase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERK1 and ERK2 cascade, actin filament organization, apoptotic process, cell adhesion, endochondral ossification, endocytosis, establishment of mitotic spindle orientation, gene expression, glucose metabolic process, immune system process, inositol trisphosphate metabolic process, lipid metabolic process, negative regulation of DNA replication, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of insulin receptor signaling pathway, negative regulation of insulin-like growth factor receptor signaling pathway, negative regulation of neuron projection development, negative regulation of platelet-derived growth factor receptor signaling pathway, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol biosynthetic process, phosphatidylinositol dephosphorylation, post-embryonic development, regulation of actin filament organization, regulation of immune response, regulation of protein localization, response to insulin, ruffle assembly; MF: SH2 domain binding, SH3 domain binding, actin binding, hydrolase activity, inositol-polyphosphate 5-phosphatase activity, phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding; CC: Golgi apparatus, basal plasma membrane, cell projection, cytoplasm, cytoskeleton, cytosol, filopodium, lamellipodium, membrane, nuclear speck, nucleus, plasma membrane, spindle pole
Pathways: B cell receptor signaling pathway - Mus musculus (mouse), Cytokine Signaling in Immune system, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Immune System, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Metabolism, Metabolism of lipids, PI Metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Signaling by Interleukins, Synthesis of IP3 and IP4 in the cytosol, Synthesis of PIPs at the plasma membrane
UniProt: Q6P549
Entrez ID: 16332
|
Does Knockout of Pex3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Pex3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pex3 (peroxisomal biogenesis factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: peroxisome membrane biogenesis, peroxisome organization, protein import into peroxisome membrane; MF: lipid binding, protein-macromolecule adaptor activity; CC: cytosol, endoplasmic reticulum, membrane, nucleoplasm, peroxisomal membrane, peroxisome, plasma membrane, protein-containing complex, protein-lipid complex
Pathways: ABC transporters in lipid homeostasis, ABC-family proteins mediated transport, Class I peroxisomal membrane protein import, Peroxisome - Mus musculus (mouse), Protein localization, Transport of small molecules
UniProt: Q9QXY9
Entrez ID: 56535
|
Does Knockout of Metap1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Metap1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Metap1 (methionyl aminopeptidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein maturation, proteolysis; MF: aminopeptidase activity, hydrolase activity, initiator methionyl aminopeptidase activity, metal ion binding, metalloaminopeptidase activity, peptidase activity, zinc ion binding; CC: cytoplasm, cytosol, cytosolic ribosome
Pathways: Inactivation, recovery and regulation of the phototransduction cascade, Sensory Perception, The phototransduction cascade, Visual phototransduction
UniProt: Q8BP48
Entrez ID: 75624
|
Does Knockout of Colec10 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Colec10
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Colec10 (collectin sub-family member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: complement activation, lectin pathway, cranial skeletal system development, defense response, embryo development ending in birth or egg hatching, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, positive chemotaxis, positive regulation of opsonization, proteolysis; MF: D-mannose binding, carbohydrate binding, chemoattractant activity; CC: Golgi apparatus, collagen trimer, cytoplasm, cytosol, extracellular region, extracellular space, nucleus
Pathways: Complement cascade, Creation of C4 and C2 activators, Immune System, Initial triggering of complement, Innate Immune System, Lectin pathway of complement activation
UniProt: Q8CF98
Entrez ID: 239447
|
Does Knockout of Garem1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Garem1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Garem1 (GRB2 associated regulator of MAPK1 subtype 1)
Type: protein-coding
Summary: Predicted to enable proline-rich region binding activity. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade. Is expressed in central nervous system; heart; lung; metanephros; and skeletal musculature. Orthologous to human GAREM1 (GRB2 associated regulator of MAPK1 subtype 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell population proliferation, cellular response to epidermal growth factor stimulus, epidermal growth factor receptor signaling pathway, multicellular organism growth, positive regulation of ERK1 and ERK2 cascade, positive regulation of cell division, positive regulation of cell population proliferation, response to epidermal growth factor; MF: proline-rich region binding
Pathways:
UniProt: Q3UFT3
Entrez ID: 381126
|
Does Knockout of Derl1 in Microglial Cell Line causally result in response to virus?
| 1
| 2,429
|
Knockout
|
Derl1
|
response to virus
|
Microglial Cell Line
|
Gene: Derl1 (Der1-like domain family, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, cellular response to misfolded protein, cellular response to stress, cellular response to unfolded protein, endoplasmic reticulum unfolded protein response, positive regulation of protein ubiquitination, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein destabilization, protein transport, response to unfolded protein, retrograde protein transport, ER to cytosol; MF: ATPase binding, MHC class I protein binding, identical protein binding, protease binding, protein binding, protein-containing complex binding, signal recognition particle binding, ubiquitin protein ligase binding, ubiquitin-specific protease binding; CC: Derlin-1 retrotranslocation complex, Derlin-1-VIMP complex, early endosome, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, late endosome, membrane
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Amyotrophic lateral sclerosis - Mus musculus (mouse), Asparagine N-linked glycosylation, Co-inhibition by PD-1, Immune System, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Transport of small molecules
UniProt: Q99J56
Entrez ID: 67819
|
Does Knockout of Commd9 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Commd9
|
cell cycle progression
|
breast epithelium
|
Gene: Commd9 (COMM domain containing 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol homeostasis, monoatomic ion transport, sodium ion transport; CC: Golgi apparatus, cytoplasmic vesicle, cytosol, nucleoplasm, nucleus
Pathways: Immune System, Innate Immune System, Metabolism of proteins, Neddylation, Neutrophil degranulation, Post-translational protein modification
UniProt: Q8K2Q0
Entrez ID: 76501
|
Does Knockout of Cyp2c40 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Cyp2c40
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cyp2c40 (cytochrome P450, family 2, subfamily c, polypeptide 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, epoxygenase P450 pathway, estrogen metabolic process, icosanoid biosynthetic process, lipid hydroxylation, lipid metabolic process, organic acid metabolic process, oxidative demethylation, retinoic acid metabolic process, steroid metabolic process, xenobiotic catabolic process, xenobiotic metabolic process; MF: arachidonate 14,15-epoxygenase activity, arachidonate epoxygenase activity, arachidonate monooxygenase activity, caffeine oxidase activity, estrogen 16-alpha-hydroxylase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, retinoic acid 4-hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, plasma membrane
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: P56657
Entrez ID: 13099
|
Does Knockout of Znhit2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Znhit2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Znhit2 (zinc finger, HIT domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, zinc ion binding
Pathways:
UniProt: Q9QY66
Entrez ID: 29805
|
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