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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Hcfc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Hcfc1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hcfc1 (host cell factor C1)
Type: protein-coding
Summary: This gene encodes a transcription cofactor that regulates the progression of cell cycle and maintain the ability of embryonic stem cells to self-renew. The encoded protein is a large precursor that undergoes site-specific proteolytic cleavage to yield N- and C-terminal chains that form a non-covalent heterodimer. The encoded protein has been implicated in the regulation of expression of immediate early genes after herpes simplex virus infection and glucose-stimulated secretion of insulin by pancreatic beta cells. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: blastocyst hatching, chromatin organization, chromatin remodeling, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of transcription by RNA polymerase II, protein stabilization, regulation of DNA-templated transcription, regulation of protein-containing complex assembly, release from viral latency; MF: DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, identical protein binding, protein binding, protein-macromolecule adaptor activity, transcription coactivator activity; CC: MLL1 complex, MLL1/2 complex, NSL complex, Set1C/COMPASS complex, axon, cytoplasm, dendrite, extracellular matrix, histone acetyltransferase complex, histone methyltransferase complex, neuronal cell body, nuclear chromosome, nucleoplasm, nucleus, protein-containing complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Deubiquitination, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones, Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of proteins, Post-translational protein modification, UCH proteinases
UniProt: Q61191
Entrez ID: 15161
|
Does Knockout of Pgam1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Pgam1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pgam1 (phosphoglycerate mutase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, gluconeogenesis, glyceraldehyde-3-phosphate biosynthetic process, glycolytic process; MF: bisphosphoglycerate mutase activity, catalytic activity, hydrolase activity, intramolecular phosphotransferase activity, isomerase activity, phosphoglycerate mutase activity, protein kinase binding; CC: cytoplasm, cytosol, myelin sheath, sperm principal piece
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Gluconeogenesis, Glucose metabolism, Glycine, serine and threonine metabolism - Mus musculus (mouse), Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Rapoport-Luebering glycolytic shunt, gluconeogenesis I, glycolysis I, glycolysis III, glycolysis V (Pyrococcus)
UniProt: Q9DBJ1
Entrez ID: 18648
|
Does Knockout of Cyb5b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Cyb5b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cyb5b (cytochrome b5 type B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nitric oxide biosynthetic process; MF: enzyme activator activity, heme binding, metal ion binding, nitrite reductase (NO-forming) activity; CC: intracellular membrane-bounded organelle, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion, nitric-oxide synthase complex
Pathways: Biological oxidations, Metabolism, Metabolism of lipids, Metabolism of nitric oxide: NOS3 activation and regulation, Phase I - Functionalization of compounds, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, eNOS activation
UniProt: Q9CQX2
Entrez ID: 66427
|
Does Knockout of Engase in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Engase
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Engase (endo-beta-N-acetylglucosaminidase)
Type: protein-coding
Summary: Predicted to enable mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity. Acts upstream of or within protein deglycosylation. Predicted to be located in cytosol. Orthologous to human ENGASE (endo-beta-N-acetylglucosaminidase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity; CC: cytoplasm, cytosol
Pathways: Asparagine N-linked glycosylation, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Other glycan degradation - Mus musculus (mouse), Post-translational protein modification
UniProt: Q8BX80
Entrez ID: 217364
|
Does Knockout of Pno1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Pno1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pno1 (partner of NOB1 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, ribosomal small subunit biogenesis; MF: RNA binding, molecular_function, nucleic acid binding; CC: nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CPS7
Entrez ID: 66249
|
Does Knockout of Naa20 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Naa20
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-terminal peptidyl-aspartic acid acetylation, N-terminal peptidyl-glutamic acid acetylation, N-terminal peptidyl-glutamine acetylation, N-terminal protein amino acid acetylation, regulation of actin cytoskeleton organization; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, protein N-terminal-methionine acetyltransferase activity, protein-N-terminal amino-acid acetyltransferase activity, transferase activity; CC: NatB complex, cytoplasm, cytosol, nucleus
Pathways:
UniProt: P61600
Entrez ID: 67877
|
Does Knockout of Polg in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Polg
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Polg (polymerase (DNA directed), gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA metabolic process, DNA replication, DNA replication proofreading, DNA-templated DNA replication, base-excision repair, determination of adult lifespan, mitochondrial DNA replication; MF: 3'-5' exonuclease activity, 5'-deoxyribose-5-phosphate lyase activity, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, catalytic activity, acting on a nucleic acid, chromatin binding, exonuclease activity, hydrolase activity, lyase activity, metal ion binding, nucleotidyltransferase activity, protease binding, protein binding, single-stranded DNA 3'-5' DNA exonuclease activity, transferase activity; CC: gamma DNA polymerase complex, mitochondrial chromosome, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, protein-containing complex, terminal bouton
Pathways:
UniProt: Q3UG70, Q75WC0, Q3UZX3, A0A0J9YTR4, A0A0J9YU70, A0A0J9YUA1, F7BP45, A0A0J9YU03, F6YLN2, D6RIP1, A0A0J9YV64, A0A0J9YTZ6
Entrez ID: 18975
|
Does Knockout of Pcdhgc5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Pcdhgc5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pcdhgc5 (protocadherin gamma subfamily C, 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of neuron apoptotic process, synapse organization; MF: calcium ion binding, cell adhesion molecule binding, metal ion binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: A0A0A6YVT4, Q91XW9, A0A0A6YXZ9
Entrez ID: 93708
|
Does Knockout of Slc2a6 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Slc2a6
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Slc2a6 (solute carrier family 2 (facilitated glucose transporter), member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose transmembrane transport, regulation of glycolytic process, transmembrane transport; MF: D-glucose transmembrane transporter activity, transmembrane transporter activity; CC: lysosomal membrane, lysosome, membrane
Pathways: Cellular hexose transport, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q3UDF0
Entrez ID: 227659
|
Does Knockout of Hmgcl in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Hmgcl
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Hmgcl (3-hydroxy-3-methylglutaryl-Coenzyme A lyase)
Type: protein-coding
Summary: Predicted to enable several functions, including anion binding activity; hydroxymethylglutaryl-CoA lyase activity; and metal ion binding activity. Acts upstream of or within mitochondrion organization. Located in mitochondrion. Is expressed in alimentary system; cranium; and liver. Human ortholog(s) of this gene implicated in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency and amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: L-leucine catabolic process, acyl-CoA metabolic process, ketone body biosynthetic process, lipid metabolic process, mitochondrion organization; MF: carboxylic acid binding, catalytic activity, fatty-acyl-CoA binding, hydroxymethylglutaryl-CoA lyase activity, lyase activity, magnesium ion binding, manganese ion binding, metal ion binding, oxo-acid-lyase activity, structural molecule activity; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrion, peroxisome, protein-containing complex
Pathways: Butanoate metabolism - Mus musculus (mouse), Ketone body metabolism, Leucine Catabolism, Metabolism, Metabolism of lipids, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Protein localization, Synthesis of Ketone Bodies, Valine, leucine and isoleucine degradation - Mus musculus (mouse), ketogenesis, leucine degradation I
UniProt: P38060
Entrez ID: 15356
|
Does Knockout of Mms22l in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Mms22l
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mms22l (MMS22-like, DNA repair protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, double-strand break repair via homologous recombination, protein localization to chromatin, replication fork processing; MF: DNA binding, molecular_function, single-stranded DNA binding; CC: FACT complex, MCM complex, chromosome, cytosol, nuclear replication fork, nucleoplasm, nucleus, site of DNA damage, site of double-strand break
Pathways:
UniProt: B1AUR6
Entrez ID: 212377
|
Does Knockout of Ap3m1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Ap3m1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ap3m1 (adaptor-related protein complex 3, mu 1 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal transport, anterograde synaptic vesicle transport, clathrin-coated vesicle cargo loading, AP-3-mediated, endocytosis, intracellular protein transport, melanosome assembly, platelet dense granule organization, postsynaptic neurotransmitter receptor internalization, protein transport, vesicle transport along microtubule, vesicle-mediated transport; MF: small GTPase binding; CC: AP-3 adaptor complex, Golgi apparatus, axon cytoplasm, clathrin adaptor complex, cytoplasmic vesicle, cytoplasmic vesicle membrane, early endosome, membrane, postsynaptic recycling endosome
Pathways: Lysosome - Mus musculus (mouse)
UniProt: Q9JKC8
Entrez ID: 55946
|
Does Knockout of Pex13 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Pex13
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pex13 (peroxisomal biogenesis factor 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to reactive oxygen species, cerebral cortex cell migration, fatty acid alpha-oxidation, locomotory behavior, microtubule-based peroxisome localization, neuron migration, protein import into peroxisome matrix, protein import into peroxisome matrix, docking, protein import into peroxisome matrix, receptor recycling, protein import into peroxisome matrix, translocation, protein transport, protein unfolding, suckling behavior; MF: peroxisome targeting sequence binding, protein transmembrane transporter activity; CC: membrane, peroxisomal importomer complex, peroxisomal membrane, peroxisome
Pathways: Class I peroxisomal membrane protein import, E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Post-translational protein modification, Protein localization, Protein ubiquitination
UniProt: Q9D0K1
Entrez ID: 72129
|
Does Knockout of Atm in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,540
|
Knockout
|
Atm
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Atm (ataxia telangiectasia mutated)
Type: protein-coding
Summary: Enables histone H2AXS139 kinase activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of TORC1 signaling; and regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including immune system development; intracellular signal transduction; and meiotic nuclear division. Located in cytoplasm; microtubule cytoskeleton; and nucleus. Is extrinsic component of synaptic vesicle membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA double-strand break processing, DNA repair, DNA strand resection involved in replication fork processing, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, V(D)J recombination, autophagosome assembly, brain development, cellular response to X-ray, cellular response to gamma radiation, cellular response to ionizing radiation, cellular response to nitrosative stress, cellular response to oxygen-containing compound, cellular response to reactive oxygen species, cellular response to retinoic acid, cellular response to stress, chromatin remodeling, chromosome organization involved in meiotic cell cycle, determination of adult lifespan, double-strand break repair, double-strand break repair via homologous recombination, establishment of RNA localization to telomere, establishment of protein-containing complex localization to telomere, female gamete generation, female gonad development, female meiotic nuclear division, heart development, histone mRNA catabolic process, immune system process, intrinsic apoptotic signaling pathway in response to DNA damage, lipoprotein catabolic process, male meiotic nuclear division, meiosis I, meiotic telomere clustering, mitotic G2 DNA damage checkpoint signaling, mitotic spindle assembly checkpoint signaling, multicellular organism growth, negative regulation of B cell proliferation, negative regulation of TORC1 signaling, negative regulation of double-strand break repair via homologous recombination, negative regulation of signal transduction by p53 class mediator, negative regulation of telomere capping, neuron apoptotic process, oocyte development, ovarian follicle development, pexophagy, phosphatidylinositol-3-phosphate biosynthetic process, positive regulation of DNA catabolic process, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of apoptotic process, positive regulation of autophagosome assembly, positive regulation of cell adhesion, positive regulation of cell migration, positive regulation of double-strand break repair, positive regulation of double-strand break repair via homologous recombination, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of neuron apoptotic process, positive regulation of telomerase catalytic core complex assembly, positive regulation of telomere maintenance via telomerase, positive regulation of telomere maintenance via telomere lengthening, positive regulation of transcription by RNA polymerase II, post-embryonic development, pre-B cell allelic exclusion, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked ubiquitination, protein autophosphorylation, protein localization to site of double-strand break, protein monoubiquitination, protein stabilization, regulation of autophagosome assembly, regulation of autophagy, regulation of cell cycle, regulation of gene expression, regulation of microglial cell activation, regulation of telomere maintenance via telomerase, replicative senescence, response to hypoxia, response to ionizing radiation, response to oxidative stress, response to starvation, signal transduction in response to DNA damage, somitogenesis, telomere maintenance, thymus development; MF: 1-phosphatidylinositol-3-kinase activity, ATP binding, DNA binding, DNA-dependent protein kinase activity, histone H2AXS139 kinase activity, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: DNA repair complex, centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytoplasmic vesicle, cytoskeleton, extrinsic component of synaptic vesicle membrane, nucleolus, nucleoplasm, nucleus, peroxisomal matrix, peroxisome, site of double-strand break, spindle
Pathways: Apoptosis - Mus musculus (mouse), Autodegradation of the E3 ubiquitin ligase COP1, Autophagy, Cell Cycle, Cell Cycle Checkpoints, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), DNA Damage/Telomere Stress Induced Senescence, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, FoxO signaling pathway - Mus musculus (mouse), G1/S DNA Damage Checkpoints, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Macroautophagy, MicroRNAs in cancer - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), Pexophagy, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Selective autophagy, Sensing of DNA Double Strand Breaks, Stabilization of p53, TP53 Regulates Transcription of Caspase Activators and Caspases, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53, Transcriptional misregulation in cancer - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint
UniProt: Q62388
Entrez ID: 11920
|
Does Knockout of Arhgef33 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Arhgef33
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Arhgef33 (Rho guanine nucleotide exchange factor 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, molecular_function
Pathways: Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, Signal Transduction, Signaling by GPCR, p75 NTR receptor-mediated signalling
UniProt: Q8BW86
Entrez ID: 381112
|
Does Knockout of Stn1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Stn1
|
cell cycle progression
|
breast epithelium
|
Gene: Stn1 (STN1, CST complex subunit)
Type: protein-coding
Summary: Enables single-stranded DNA binding activity and telomeric DNA binding activity. Involved in positive regulation of DNA replication. Located in chromosome, telomeric region and nucleus. Part of CST complex. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human STN1 (STN1 subunit of CST complex). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of telomere maintenance via telomerase, positive regulation of DNA replication, regulation of DNA metabolic process, telomere capping, telomere maintenance, telomere maintenance via telomere lengthening; MF: DNA binding, protein binding, single-stranded DNA binding, single-stranded telomeric DNA binding, telomeric DNA binding; CC: CST complex, chromosome, chromosome, telomeric region, fibrillar center, intermediate filament cytoskeleton, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: Q8K2X3
Entrez ID: 108689
|
Does Knockout of Ppif in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ppif
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ppif (peptidylprolyl isomerase F (cyclophilin F))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic mitochondrial changes, apoptotic process, cellular response to arsenic-containing substance, cellular response to calcium ion, cellular response to hydrogen peroxide, mitochondrial depolarization, mitochondrial outer membrane permeabilization involved in programmed cell death, mitochondrion organization, muscle structure development, necroptotic process, negative regulation of apoptotic process, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of oxidative phosphorylation, negative regulation of release of cytochrome c from mitochondria, programmed cell death, protein folding, regulation of apoptotic process, regulation of mitochondrial membrane permeability, regulation of mitochondrial membrane permeability involved in programmed necrotic cell death, regulation of proton-transporting ATPase activity, rotational mechanism, response to ischemia, response to oxidative stress, skeletal muscle fiber differentiation; MF: cyclosporin A binding, isomerase activity, peptide binding, peptidyl-prolyl cis-trans isomerase activity, protein binding; CC: cytoplasm, mitochondrial inner membrane, mitochondrial matrix, mitochondrial permeability transition pore complex, mitochondrion
Pathways: Alzheimer disease - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q99KR7
Entrez ID: 105675
|
Does Knockout of Itgb1bp2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Itgb1bp2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Itgb1bp2 (integrin beta 1 binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: SH3 domain binding, calcium ion binding, integrin binding, metal ion binding, protein binding, zinc ion binding; CC: Z disc
Pathways:
UniProt: Q9R000
Entrez ID: 26549
|
Does Knockout of Sav1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Sav1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sav1 (salvador family WW domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, hair follicle development, hippo signaling, intestinal epithelial cell differentiation, keratinocyte differentiation, lung epithelial cell differentiation, negative regulation of cardiac muscle cell proliferation, negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation, negative regulation of hippo signaling, positive regulation of apoptotic process, positive regulation of fat cell differentiation, positive regulation of hippo signaling, positive regulation of keratinocyte apoptotic process, protein stabilization, regulation of cell population proliferation, regulation of gene expression, regulation of organ growth, regulation of stem cell population maintenance, signal transduction, ventricular septum morphogenesis; MF: identical protein binding, molecular adaptor activity, protein binding, protein serine/threonine kinase activator activity, transcription regulator activator activity; CC: cytoplasm, cytosol, nucleus
Pathways: Hippo signaling pathway - Mus musculus (mouse), Hippo signaling pathway - multiple species - Mus musculus (mouse), Signal Transduction, Signaling by Hippo
UniProt: Q8VEB2
Entrez ID: 64010
|
Does Knockout of Dgkk in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 0
| 1,522
|
Knockout
|
Dgkk
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Dgkk (diacylglycerol kinase kappa)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: diacylglycerol metabolic process, glycerolipid metabolic process, intracellular signal transduction, lipid metabolic process, phosphatidic acid biosynthetic process, phospholipase C-activating G protein-coupled receptor signaling pathway, response to oxidative stress, signal transduction; MF: ATP binding, ATP-dependent diacylglycerol kinase activity, kinase activity, metal ion binding, nucleotide binding, transferase activity, zinc ion binding; CC: cytoplasm, plasma membrane
Pathways: Choline metabolism in cancer - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid metabolism - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse)
UniProt: Q6DIC8
Entrez ID: 331374
|
Does Knockout of Vipr2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Vipr2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Vipr2 (vasoactive intestinal peptide receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, negative regulation of smooth muscle cell proliferation, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, peptide hormone binding, pituitary adenylate cyclase-activating polypeptide receptor activity, transmembrane signaling receptor activity, vasoactive intestinal polypeptide receptor activity; CC: membrane, plasma membrane
Pathways: Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Glucagon-type ligand receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: P41588
Entrez ID: 22355
|
Does Knockout of Yeats2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Yeats2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Yeats2 (YEATS domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II; MF: TBP-class protein binding, histone binding, histone reader activity, modification-dependent protein binding, transcription corepressor activity; CC: ATAC complex, NuA4 histone acetyltransferase complex, mitotic spindle, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription)
UniProt: Q3TUF7
Entrez ID: 208146
|
Does Knockout of Gck in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Gck
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gck (glucokinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NADP+ metabolic process, calcium ion import, carbohydrate metabolic process, carbohydrate phosphorylation, cellular response to glucose starvation, cellular response to insulin stimulus, cellular response to leptin stimulus, establishment of localization in cell, fructose 2,6-bisphosphate metabolic process, fructose 6-phosphate metabolic process, glucose 6-phosphate metabolic process, glucose catabolic process, glucose homeostasis, glucose metabolic process, glycogen biosynthetic process, glycolytic process, hexose metabolic process, intracellular glucose homeostasis, lipid homeostasis, mannose metabolic process, negative regulation of epinephrine secretion, negative regulation of gluconeogenesis, nicotinamide nucleotide metabolic process, positive regulation of cytosolic calcium ion concentration, positive regulation of glycogen biosynthetic process, positive regulation of glycolytic process, positive regulation of insulin secretion, positive regulation of phosphorylation, purine nucleotide metabolic process, regulation of glucose mediated signaling pathway, regulation of insulin secretion, regulation of potassium ion transport, response to glucose; MF: ADP binding, ATP binding, D-glucose binding, catalytic activity, fructokinase activity, glucokinase activity, glucose sensor activity, hexokinase activity, kinase activity, magnesium ion binding, mannokinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein binding, protein phosphatase binding, transferase activity; CC: actin filament, basal cortex, cell cortex, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, secretory granule
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), GDP-glucose biosynthesis, Galactose metabolism - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Maturity onset diabetes of the young - Mus musculus (mouse), Neomycin, kanamycin and gentamicin biosynthesis - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Starch and sucrose metabolism - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse), glucose and glucose-1-phosphate degradation, glycolysis III, trehalose degradation II (trehalase)
UniProt: P52792
Entrez ID: 103988
|
Does Knockout of Rictor in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Rictor
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rictor (RPTOR independent companion of MTOR, complex 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TOR signaling, TORC2 signaling, actin cytoskeleton organization, cGAS/STING signaling pathway, cellular response to nutrient levels, cytoskeleton organization, embryo development ending in birth or egg hatching, lipid biosynthetic process, negative regulation of apoptotic process, negative regulation of cGAS/STING signaling pathway, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of TOR signaling, positive regulation of actin filament polymerization, positive regulation of cell growth, positive regulation of cell migration, positive regulation of endothelial cell proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of actin cytoskeleton organization, regulation of establishment of cell polarity, regulation of gene expression, regulation of inflammatory response, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of protein phosphorylation; MF: ATP binding, enzyme-substrate adaptor activity, metal ion binding, molecular adaptor activity, nucleotide binding, protein binding, protein kinase binding, protein serine/threonine kinase activator activity, ribosome binding, zinc ion binding; CC: TORC2 complex, endoplasmic reticulum, endoplasmic reticulum membrane, lysosomal membrane, lysosome, membrane, plasma membrane, serine/threonine protein kinase complex
Pathways: Adaptive Immune System, CD28 dependent PI3K/Akt signaling, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Co-stimulation by CD28, Gene expression (Transcription), Generic Transcription Pathway, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Immune System, Intracellular signaling by second messengers, PIP3 activates AKT signaling, RNA Polymerase II Transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Response of endothelial cells to shear stress, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Transcriptional Regulation by TP53, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q6QI06
Entrez ID: 78757
|
Does Knockout of Siah1a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Siah1a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Siah1a (siah E3 ubiquitin protein ligase 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, canonical Wnt signaling pathway, cell differentiation, male meiosis I, neuron apoptotic process, positive regulation of apoptotic process, positive regulation of intrinsic apoptotic signaling pathway, post-embryonic development, proteasome-mediated ubiquitin-dependent protein catabolic process, protein catabolic process, protein destabilization, protein ubiquitination, regulation of multicellular organism growth, spermatogenesis, ubiquitin-dependent protein catabolic process; MF: disordered domain specific binding, identical protein binding, metal ion binding, protein binding, protein homodimerization activity, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: SCF ubiquitin ligase complex, beta-catenin destruction complex, cytoplasm, cytosol, early endosome, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Ubiquitin mediated proteolysis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P61092
Entrez ID: 20437
|
Does Knockout of Slit2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Slit2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slit2 (slit guidance ligand 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Slit family of secreted glycoproteins, which function as ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. In mammals, members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Mice deficient for this gene exhibit abnormal axonal projections in the embryonic forebrain and develop supernumerary uretic buds that maintain improper connections to the nephric duct. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: Roundabout signaling pathway, aortic valve morphogenesis, axon extension involved in axon guidance, axon guidance, axonogenesis, branching morphogenesis of an epithelial tube, cell differentiation, cell migration involved in sprouting angiogenesis, cell-cell adhesion, cellular response to heparin, chemorepulsion involved in postnatal olfactory bulb interneuron migration, chemotaxis, corticospinal neuron axon guidance through spinal cord, developmental growth involved in morphogenesis, dorsal/ventral axon guidance, epithelial tube morphogenesis, in utero embryonic development, induction of negative chemotaxis, kidney development, mammary duct terminal end bud growth, mammary gland duct morphogenesis, metanephros development, motor neuron axon guidance, negative chemotaxis, negative regulation of actin filament polymerization, negative regulation of axon extension, negative regulation of cell growth, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of cellular response to growth factor stimulus, negative regulation of chemokine-mediated signaling pathway, negative regulation of endothelial cell migration, negative regulation of gene expression, negative regulation of lamellipodium assembly, negative regulation of leukocyte chemotaxis, negative regulation of monocyte chemotaxis, negative regulation of mononuclear cell migration, negative regulation of neuron projection development, negative regulation of neutrophil chemotaxis, negative regulation of retinal ganglion cell axon guidance, negative regulation of small GTPase mediated signal transduction, negative regulation of smooth muscle cell chemotaxis, negative regulation of smooth muscle cell migration, negative regulation of vascular permeability, nervous system development, neuron projection extension, neuron projection morphogenesis, olfactory bulb development, positive regulation of apoptotic process, positive regulation of synapse assembly, pulmonary valve morphogenesis, regulation of axonogenesis, regulation of cellular component size, regulation of neurogenesis, retinal ganglion cell axon guidance, signal transduction, synapse maturation, telencephalon cell migration, ureteric bud development, ventricular septum morphogenesis; MF: GTPase inhibitor activity, Roundabout binding, calcium ion binding, chemorepellent activity, extracellular matrix structural constituent, heparan sulfate proteoglycan binding, heparin binding, identical protein binding, laminin-1 binding, protein binding, protein homodimerization activity, proteoglycan binding, signaling receptor binding; CC: axon, cell body, cell projection, cell surface, cytoplasm, dendrite, extracellular matrix, extracellular region, extracellular space, neuronal cell body, perisynaptic extracellular matrix, plasma membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, Nervous system development, Regulation of expression of SLITs and ROBOs, Role of ABL in ROBO-SLIT signaling, SLIT2:ROBO1 increases RHOA activity, Signaling by ROBO receptors
UniProt: Q9R1B9
Entrez ID: 20563
|
Does Knockout of Mpi in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Mpi
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mpi (mannose phosphate isomerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GDP-D-mannose biosynthetic process from fructose-6-phosphate, GDP-mannose biosynthetic process, carbohydrate metabolic process, glycolytic process from mannose through fructose-6-phosphate, mannose to fructose-6-phosphate catabolic process; MF: isomerase activity, mannose-6-phosphate isomerase activity, metal ion binding, zinc ion binding; CC: cytoplasm, cytosol
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, D-mannose degradation, Fructose and mannose metabolism - Mus musculus (mouse), GDP-mannose biosynthesis, GDP-mannose biosynthesis I, GDP-mannose metabolism, Metabolism of proteins, Post-translational protein modification, Synthesis of GDP-mannose, Synthesis of substrates in N-glycan biosythesis, colanic acid building blocks biosynthesis, mannitol degradation II
UniProt: Q924M7
Entrez ID: 110119
|
Does Knockout of Dtx2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Dtx2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dtx2 (deltex 2, E3 ubiquitin ligase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, protein ubiquitination; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, nuclear membrane, nucleoplasm, nucleus
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Notch signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1
UniProt: Q8R3P2
Entrez ID: 74198
|
Does Knockout of Gpr139 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Gpr139
|
cell cycle progression
|
breast epithelium
|
Gene: Gpr139 (G protein-coupled receptor 139)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, neuropeptide signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, identical protein binding, neuropeptide receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q80UC8
Entrez ID: 209776
|
Does Knockout of Uqcrc2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Uqcrc2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Uqcrc2 (ubiquinol cytochrome c reductase core protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, proteolysis, response to xenobiotic stimulus; MF: metal ion binding, metalloendopeptidase activity, protein binding, protein-containing complex binding; CC: membrane, mitochondrial inner membrane, mitochondrion, myelin sheath, nucleoplasm, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex III assembly, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9DB77
Entrez ID: 67003
|
Does Knockout of Kcnj13 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Kcnj13
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Kcnj13 (potassium inwardly-rectifying channel, subfamily J, member 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of monoatomic ion transmembrane transport; MF: inward rectifier potassium channel activity, potassium channel activity; CC: membrane, monoatomic ion channel complex, plasma membrane
Pathways: Protein digestion and absorption - Mus musculus (mouse)
UniProt: P86046
Entrez ID: 100040591
|
Does Knockout of Tm4sf5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Tm4sf5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tm4sf5 (transmembrane 4 superfamily member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of G1/S transition of mitotic cell cycle; MF: arginine binding; CC: lysosomal membrane, membrane, plasma membrane
Pathways:
UniProt: Q9D8G1, Q91XF2
Entrez ID: 75604
|
Does Knockout of Cd320 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Cd320
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cd320 (CD320 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell costimulation, cobalamin transport, positive regulation of B cell proliferation, regulation of vitamin metabolic process, signal transduction, vesicle-mediated transport; MF: calcium ion binding, cargo receptor activity, cobalamin binding, growth factor activity, metal ion binding; CC: endoplasmic reticulum, membrane, plasma membrane
Pathways: Cobalamin (Cbl, vitamin B12) transport and metabolism, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Transport of RCbl within the body
UniProt: Q9Z1P5
Entrez ID: 54219
|
Does Knockout of Rnaseh2c in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Rnaseh2c
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rnaseh2c (ribonuclease H2, subunit C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, mismatch repair; CC: nucleus, ribonuclease H2 complex
Pathways: DNA replication - Mus musculus (mouse)
UniProt: Q9CQ18
Entrez ID: 68209
|
Does Knockout of Tsc22d2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Tsc22d2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tsc22d2 (TSC22 domain family, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell cycle, regulation of transcription by RNA polymerase II, response to osmotic stress
Pathways:
UniProt: E9Q7M2
Entrez ID: 72033
|
Does Knockout of Plekha2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Plekha2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Plekha2 (pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell-matrix adhesion; MF: PDZ domain binding, fibronectin binding, laminin binding, lipid binding, phosphatidylinositol-3,4-bisphosphate binding, phospholipid binding, protein binding; CC: cytoplasm, membrane, nucleus, plasma membrane, protein-containing complex
Pathways: Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism, Synthesis of PIPs at the plasma membrane
UniProt: Q9ERS5
Entrez ID: 83436
|
Does Knockout of Ldlrap1 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Ldlrap1
|
cell proliferation
|
Regulatory T cell
|
Gene: Ldlrap1 (low density lipoprotein receptor adaptor protein 1)
Type: protein-coding
Summary: Enables amyloid-beta binding activity. Acts upstream of or within cholesterol homeostasis. Located in early endosome and neurofilament. Is expressed in extraembryonic endoderm; nose; and skin. Used to study autosomal recessive hypercholesterolemia. Human ortholog(s) of this gene implicated in autosomal recessive hypercholesterolemia. Orthologous to human LDLRAP1 (low density lipoprotein receptor adaptor protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: amyloid precursor protein metabolic process, cellular response to cytokine stimulus, cholesterol homeostasis, cholesterol metabolic process, endocytosis, lipid metabolic process, low-density lipoprotein particle clearance, positive regulation of low-density lipoprotein particle clearance, positive regulation of receptor-mediated endocytosis, positive regulation of receptor-mediated endocytosis involved in cholesterol transport, positive regulation of vascular associated smooth muscle cell proliferation, receptor internalization, receptor-mediated endocytosis, receptor-mediated endocytosis involved in cholesterol transport, regulation of protein localization to plasma membrane, steroid metabolic process; MF: AP-1 adaptor complex binding, AP-2 adaptor complex binding, amyloid-beta binding, clathrin adaptor activity, clathrin binding, low-density lipoprotein particle receptor binding, phosphatidylinositol-4,5-bisphosphate binding, phosphotyrosine residue binding, protein binding, signaling adaptor activity, signaling receptor binding, signaling receptor complex adaptor activity; CC: axon, basal plasma membrane, cytoplasm, cytoplasmic side of plasma membrane, cytosol, early endosome, neurofilament, recycling endosome
Pathways: Cargo recognition for clathrin-mediated endocytosis, Cholesterol metabolism - Mus musculus (mouse), Chylomicron clearance, Clathrin-mediated endocytosis, Cobalamin (Cbl, vitamin B12) transport and metabolism, Endocytosis - Mus musculus (mouse), LDL clearance, Membrane Trafficking, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Transport of RCbl within the body, Transport of small molecules, Vesicle-mediated transport
UniProt: Q8C142
Entrez ID: 100017
|
Does Knockout of Ly6c1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Ly6c1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Ly6c1 (lymphocyte antigen 6 family member C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acetylcholine receptor binding, acetylcholine receptor inhibitor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane, side of membrane, synapse
Pathways:
UniProt: P0CW02
Entrez ID: 17067
|
Does Knockout of Dhcr24 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Dhcr24
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Dhcr24 (24-dehydrocholesterol reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, amyloid precursor protein catabolic process, cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, intracellular protein localization, lipid metabolic process, male genitalia development, membrane organization, negative regulation of cell population proliferation, plasminogen activation, response to hormone, skin development, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, sterol metabolic process, tissue development; MF: Delta24(24-1) sterol reductase activity, Delta24-sterol reductase activity, FAD binding, enzyme binding, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor, peptide antigen binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Cholesterol biosynthesis, Cholesterol biosynthesis via desmosterol, Cholesterol biosynthesis via lathosterol, Metabolism, Metabolism of lipids, Metabolism of steroids, Steroid biosynthesis - Mus musculus (mouse), cholesterol biosynthesis I, superpathway of cholesterol biosynthesis
UniProt: Q8VCH6
Entrez ID: 74754
|
Does Knockout of Rsph14 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Rsph14
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rsph14 (radial spoke head homolog 14 (Chlamydomonas))
Type: protein-coding
Summary: Predicted to be involved in epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and mating. Part of radial spoke. Is expressed in lung epithelium and nasal cavity respiratory epithelium. Orthologous to human RSPH14 (radial spoke head 14 homolog). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, epithelial cilium movement involved in extracellular fluid movement, flagellated sperm motility, mating; CC: 9+2 motile cilium, cell projection, cellular_component, cilium, cytoplasm, cytoskeleton, extracellular region, motile cilium, radial spoke, sperm flagellum
Pathways:
UniProt: Q9D3W1
Entrez ID: 71236
|
Does Knockout of Il27ra in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Il27ra
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Il27ra (interleukin 27 receptor, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, defense response to Gram-positive bacterium, interleukin-27-mediated signaling pathway, negative regulation of T cell extravasation, negative regulation of T-helper 17 type immune response, negative regulation of cellular extravasation, negative regulation of interleukin-17 production, negative regulation of interleukin-6 production, negative regulation of neuron apoptotic process, negative regulation of tumor necrosis factor production, negative regulation of type 2 immune response, positive regulation of T-helper 1 type immune response, positive regulation of type II interferon production, regulation of isotype switching to IgG isotypes; MF: interleukin-27 receptor activity, protein binding, transmembrane signaling receptor activity; CC: cytoplasm, extracellular region, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-12 family signaling, Interleukin-27 signaling, Interleukin-35 Signalling, JAK-STAT signaling pathway - Mus musculus (mouse), Signaling by Interleukins, Th17 cell differentiation - Mus musculus (mouse)
UniProt: O70394
Entrez ID: 50931
|
Does Knockout of Ndufa1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Ndufa1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ndufa1 (NADH:ubiquinone oxidoreductase subunit A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: O35683
Entrez ID: 54405
|
Does Knockout of Cped1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Cped1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cped1 (cadherin-like and PC-esterase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endoplasmic reticulum
Pathways:
UniProt: A0A2Z4MSG2, B2RX70, D3YUQ2, E9Q7L8, S4R2A1
Entrez ID: 214642
|
Does Knockout of Pcdhga12 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,278
|
Knockout
|
Pcdhga12
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pcdhga12 (protocadherin gamma subfamily A, 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, protein binding; CC: cell-cell junction, membrane, plasma membrane
Pathways:
UniProt: Q91XY7
Entrez ID: 93724
|
Does Knockout of Urod in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Urod
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Urod (uroporphyrinogen decarboxylase)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the conversion of uroporphyrinogen-III to coproporphyrinogen-III, an intermediate step in heme biosynthesis. Homozygous knockout mice for this gene exhibit embryonic lethality. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: cell population proliferation, heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, heme metabolic process, porphyrin-containing compound biosynthetic process, porphyrin-containing compound catabolic process, porphyrin-containing compound metabolic process, protoporphyrinogen IX biosynthetic process, uroporphyrinogen III metabolic process; MF: carboxy-lyase activity, ferrous iron binding, lyase activity, uroporphyrinogen decarboxylase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Heme biosynthesis, Metabolism, Metabolism of porphyrins, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, heme biosynthesis from uroporphyrinogen-III I
UniProt: P70697
Entrez ID: 22275
|
Does Knockout of Fasn in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Fasn
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fasn (fatty acid synthase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetyl-CoA metabolic process, cellular response to interleukin-4, epithelial cell development, establishment of endothelial intestinal barrier, ether lipid biosynthetic process, fatty acid biosynthetic process, fatty acid metabolic process, host-mediated perturbation of viral process, inflammatory response, lipid biosynthetic process, lipid metabolic process, mammary gland development, monocyte differentiation, neutrophil differentiation, response to caloric restriction, response to nutrient, response to nutrient levels, tissue development; MF: (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity, 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity, 3-oxoacyl-[acyl-carrier-protein] synthase activity, [acyl-carrier-protein] S-acetyltransferase activity, [acyl-carrier-protein] S-malonyltransferase activity, acyltransferase activity, catalytic activity, enoyl-[acyl-carrier-protein] reductase (NADPH) activity, fatty acid synthase activity, fatty acyl-[ACP] hydrolase activity, hydrolase activity, identical protein binding, lyase activity, oxidoreductase activity, phosphopantetheine binding, transferase activity; CC: Golgi apparatus, cytoplasm, cytosol, glycogen granule, melanosome, mitochondrion, plasma membrane
Pathways: AMPK signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Insulin signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Vitamin B5 (pantothenate) metabolism, acyl-ACP thioesterase pathway, fatty acid biosynthesis initiation II, fatty acid biosynthesis initiation III, palmitate biosynthesis I (animals)
UniProt: P19096
Entrez ID: 14104
|
Does Knockout of Rnf214 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Rnf214
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rnf214 (ring finger protein 214)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, ubiquitin-protein transferase activity, zinc ion binding
Pathways:
UniProt: Q8BFU3
Entrez ID: 235315
|
Does Knockout of Ubald2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ubald2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ubald2 (UBA-like domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BQH4
Entrez ID: 319370
|
Does Knockout of Vmn1r235 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Vmn1r235
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vmn1r235 (vomeronasal 1 receptor 235)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A494B9G6, Q8R297, A0A494B9T5
Entrez ID: 171233
|
Does Knockout of Syp in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Syp
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Syp (synaptophysin)
Type: protein-coding
Summary: Enables SH2 domain binding activity and identical protein binding activity. Involved in regulation of long-term neuronal synaptic plasticity; regulation of short-term neuronal synaptic plasticity; and regulation of synaptic vesicle priming. Located in several cellular components, including neuromuscular junction; presynaptic membrane; and synaptic vesicle membrane. Is active in Schaffer collateral - CA1 synapse and presynaptic active zone. Is expressed in several structures, including diaphragm; gut; nervous system; sensory organ; and skeletal muscle. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to human SYP (synaptophysin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chemical synaptic transmission, endocytosis, modulation of chemical synaptic transmission, protein homooligomerization, regulation of long-term neuronal synaptic plasticity, regulation of neuronal synaptic plasticity, regulation of opioid receptor signaling pathway, regulation of short-term neuronal synaptic plasticity, regulation of synaptic vesicle priming; MF: SH2 domain binding, SNARE binding, cholesterol binding, identical protein binding, protein binding, protein domain specific binding, protein-containing complex binding, syntaxin-1 binding; CC: Schaffer collateral - CA1 synapse, clathrin-sculpted glutamate transport vesicle membrane, cytoplasmic vesicle, excitatory synapse, membrane, neuromuscular junction, neuron projection, neuron projection terminus, neuron spine, perinuclear region of cytoplasm, postsynaptic density, presynapse, presynaptic active zone, presynaptic membrane, protein-containing complex, synapse, synaptic vesicle, synaptic vesicle membrane, terminal bouton
Pathways:
UniProt: Q62277
Entrez ID: 20977
|
Does Knockout of Nrros in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Nrros
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nrros (negative regulator of reactive oxygen species)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, immune response, inflammatory response, innate immune response, microglia development, sequestering of TGFbeta in extracellular matrix, superoxide metabolic process, transforming growth factor beta receptor signaling pathway; MF: growth factor binding, protein binding, receptor ligand inhibitor activity, transforming growth factor beta binding; CC: cell surface, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular space, membrane, plasma membrane
Pathways:
UniProt: Q8BMT4
Entrez ID: 224109
|
Does Knockout of Evl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Evl
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Evl (Ena-vasodilator stimulated phosphoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, actin filament-based movement, actin nucleation, actin polymerization or depolymerization, axon guidance, barbed-end actin filament capping, cellular response to type II interferon, negative regulation of epithelial cell migration, negative regulation of ruffle assembly, platelet activation, positive regulation of actin filament polymerization, positive regulation of cellular component biogenesis, positive regulation of cytoskeleton organization, positive regulation of stress fiber assembly, positive regulation of supramolecular fiber organization, protein homotetramerization, regulation of actin filament organization; MF: SH3 domain binding, actin binding, profilin binding, protein binding; CC: cell projection, cytoplasm, cytoskeleton, focal adhesion, lamellipodium, phagocytic vesicle, plasma membrane, stress fiber
Pathways: Axon guidance, Developmental Biology, Nervous system development, RHO GTPase Effectors, RHO GTPases Activate Formins, Rap1 signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by ROBO receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P70429
Entrez ID: 14026
|
Does Knockout of Cul2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Cul2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cul2 (cullin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, protein catabolic process, protein ubiquitination, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: protein binding, protein-containing complex binding, protein-macromolecule adaptor activity, ubiquitin ligase complex scaffold activity, ubiquitin protein ligase binding; CC: Cul2-RING ubiquitin ligase complex, SCF ubiquitin ligase complex, VCB complex, cullin-RING ubiquitin ligase complex, nuclear lumen, nucleolus, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, HIF-1 signaling pathway - Mus musculus (mouse), Immune System, Metabolism of proteins, Neddylation, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Renal cell carcinoma - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Translation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9D4H8
Entrez ID: 71745
|
Does Knockout of Snrpe in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Snrpe
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Snrpe (small nuclear ribonucleoprotein E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal snRNP assembly; MF: RNA binding, U1 snRNP binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, cytoplasm, cytosol, methylosome, nucleus, pICln-Sm protein complex, precatalytic spliceosome, ribonucleoprotein complex, spliceosomal complex, telomerase holoenzyme complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62305
Entrez ID: 20643
|
Does Knockout of Aasdhppt in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Aasdhppt
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Aasdhppt (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 10-formyltetrahydrofolate catabolic process, lysine biosynthetic process via aminoadipic acid, protein maturation; MF: holo-[acyl-carrier-protein] synthase activity, magnesium ion binding, metal ion binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Vitamin B5 (pantothenate) metabolism
UniProt: Q9CQF6
Entrez ID: 67618
|
Does Knockout of Ivns1abp in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ivns1abp
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ivns1abp (influenza virus NS1A binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of protein ubiquitination, proteasome-mediated ubiquitin-dependent protein catabolic process, response to virus; MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, cytoskeleton, cytosol, nucleus
Pathways:
UniProt: Q920Q8
Entrez ID: 117198
|
Does Knockout of Topaz1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Topaz1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Topaz1 (testis and ovary specific PAZ domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cell differentiation, ectopic germ cell programmed cell death, lncRNA transcription, spermatocyte division, spermatogenesis; CC: cellular_component, cytoplasm, cytosol
Pathways:
UniProt: E5FYH1
Entrez ID: 671232
|
Does Knockout of Gpr135 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Gpr135
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gpr135 (G protein-coupled receptor 135)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, arrestin family protein binding; CC: endosome, endosome membrane, membrane, plasma membrane
Pathways:
UniProt: Q7TQP2
Entrez ID: 238252
|
Does Knockout of Ska3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Ska3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ska3 (spindle and kinetochore associated complex subunit 3)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity. Involved in establishment of meiotic spindle orientation and spindle assembly involved in female meiosis. Located in meiotic spindle. Is expressed in several structures, including brain; heart ventricle; lung; and vertebral axis musculature. Orthologous to human SKA3 (spindle and kinetochore associated complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, cell division, chromosome segregation, establishment of meiotic spindle orientation, metaphase chromosome alignment, mitotic cell cycle, mitotic metaphase chromosome alignment, mitotic sister chromatid segregation, negative regulation of mitotic spindle assembly checkpoint signaling, regulation of microtubule polymerization or depolymerization, spindle assembly involved in female meiosis; MF: microtubule binding, molecular_function; CC: SKA complex, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, meiotic spindle, microtubule, mitotic spindle, outer kinetochore, spindle, spindle microtubule
Pathways:
UniProt: Q8C263
Entrez ID: 219114
|
Does Knockout of Glt1d1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Glt1d1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Glt1d1 (glycosyltransferase 1 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: glycosyltransferase activity, molecular_function, transferase activity; CC: cytosol, extracellular region
Pathways:
UniProt: A4FUP9
Entrez ID: 319804
|
Does Knockout of Naa30 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Naa30
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Naa30 (N(alpha)-acetyltransferase 30, NatC catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, protein N-terminal-methionine acetyltransferase activity, protein-N-terminal amino-acid acetyltransferase activity, transferase activity; CC: NatC complex, cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8CES0
Entrez ID: 70646
|
Does Knockout of Mark2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Mark2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mark2 (MAP/microtubule affinity regulating kinase 2)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and tau protein binding activity. Predicted to be involved in several processes, including generation of neurons; protein phosphorylation; and regulation of neuron projection development. Located in basal cortex and nucleus. Is active in glutamatergic synapse and postsynapse. Is expressed in brain; early conceptus; and oocyte. Orthologous to human MARK2 (microtubule affinity regulating kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: Wnt signaling pathway, axon development, cell differentiation, establishment of cell polarity, establishment or maintenance of cell polarity regulating cell shape, establishment or maintenance of epithelial cell apical/basal polarity, intracellular signal transduction, microtubule cytoskeleton organization, neuron migration, positive regulation of neuron projection development, protein autophosphorylation, protein phosphorylation, regulation of axonogenesis, regulation of cytoskeleton organization, regulation of microtubule cytoskeleton organization, regulation of neurofibrillary tangle assembly, regulation of postsynapse organization; MF: ATP binding, kinase activity, lipid binding, magnesium ion binding, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity, transferase activity; CC: actin filament, basal cortex, cell projection, cytoplasm, cytoskeleton, dendrite, glutamatergic synapse, lateral plasma membrane, membrane, microtubule bundle, nucleoplasm, nucleus, plasma membrane, postsynapse
Pathways:
UniProt: Q05512
Entrez ID: 13728
|
Does Knockout of Bbs4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Bbs4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Bbs4 (Bardet-Biedl syndrome 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell homeostasis, Wnt signaling pathway, adipose tissue development, adult behavior, brain morphogenesis, cell projection organization, centrosome cycle, cerebral cortex development, cilium assembly, dendrite development, erythrocyte homeostasis, face development, fat cell differentiation, fat pad development, gene expression, hippocampus development, homeostasis of number of cells, intracellular protein localization, leptin-mediated signaling pathway, leukocyte homeostasis, lymphocyte homeostasis, maintenance of protein location in nucleus, microtubule anchoring at centrosome, microtubule cytoskeleton organization, mitotic cytokinesis, myeloid cell homeostasis, negative regulation of actin filament polymerization, negative regulation of appetite by leptin-mediated signaling pathway, negative regulation of gene expression, negative regulation of systemic arterial blood pressure, neural tube closure, neuron migration, non-motile cilium assembly, photoreceptor cell maintenance, photoreceptor cell outer segment organization, positive regulation of cilium assembly, positive regulation of multicellular organism growth, protein localization to centrosome, protein localization to cilium, protein localization to photoreceptor outer segment, protein transport, regulation of cilium beat frequency involved in ciliary motility, regulation of cytokinesis, regulation of lipid metabolic process, regulation of non-motile cilium assembly, regulation of stress fiber assembly, response to leptin, retina homeostasis, retinal rod cell development, sensory perception, sensory perception of smell, social behavior, sperm flagellum assembly, spermatid development, striatum development, ventricular system development; MF: RNA polymerase II-specific DNA-binding transcription factor binding, alpha-tubulin binding, beta-tubulin binding, dynactin binding, protein binding, protein-macromolecule adaptor activity; CC: BBSome, cell projection, centriolar satellite, centriole, centrosome, ciliary basal body, ciliary membrane, ciliary transition zone, cilium, cytoplasm, cytoskeleton, membrane, motile cilium, non-motile cilium, nucleus, pericentriolar material, photoreceptor connecting cilium, photoreceptor inner segment, photoreceptor outer segment, plasma membrane
Pathways: BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q8C1Z7
Entrez ID: 102774
|
Does Knockout of Npepps in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Npepps
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Npepps (aminopeptidase puromycin sensitive)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, peptide catabolic process, proteolysis; MF: alanyl aminopeptidase activity, aminopeptidase activity, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: cytoplasm, cytosol, extracellular region, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q11011
Entrez ID: 19155
|
Does Knockout of Sars2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Sars2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sars2 (seryl-aminoacyl-tRNA synthetase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial seryl-tRNA aminoacylation, seryl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, serine-tRNA ligase activity, tRNA binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), selenocysteine biosynthesis II (archaea and eukaryotes), tRNA charging pathway
UniProt: Q9JJL8
Entrez ID: 71984
|
Does Knockout of Pcdh17 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Pcdh17
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Pcdh17 (protocadherin 17)
Type: protein-coding
Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: adult behavior, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of synaptic transmission, presynaptic active zone assembly, regulation of synaptic vesicle clustering, synaptic membrane adhesion; MF: calcium ion binding, cell adhesion molecule binding; CC: GABA-ergic synapse, glutamatergic synapse, membrane, plasma membrane, postsynaptic membrane, presynaptic membrane
Pathways:
UniProt: Q5HZI5, Q3UTP0, E9PXF0
Entrez ID: 219228
|
Does Knockout of Huwe1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Huwe1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Huwe1 (HECT, UBA and WWE domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, Golgi organization, base-excision repair, canonical NF-kappaB signal transduction, cell differentiation, chromatin remodeling, circadian regulation of gene expression, defense response to bacterium, membrane fusion, negative regulation of canonical NF-kappaB signal transduction, negative regulation of mitochondrial fusion, negative regulation of peroxisome proliferator activated receptor signaling pathway, peroxisome proliferator activated receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein ubiquitination, positive regulation of type 2 mitophagy, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein branched polyubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, rhythmic process, ubiquitin-dependent protein catabolic process; MF: DNA binding, histone ubiquitin ligase activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity; CC: Golgi membrane, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Innate Immune System, Neutrophil degranulation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q7TMY8
Entrez ID: 59026
|
Does Knockout of Aggf1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Aggf1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Aggf1 (angiogenic factor with G patch and FHA domains 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and nucleic acid binding activity. Predicted to be involved in cell adhesion; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; egg cylinder; genitourinary system; primitive streak; and sensory organ. Orthologous to human AGGF1 (angiogenic factor with G-patch and FHA domains 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: angiogenesis, cell adhesion, cell differentiation, positive regulation of angiogenesis, positive regulation of endothelial cell proliferation; MF: identical protein binding, nucleic acid binding; CC: cytoplasm, extracellular region, perinuclear region of cytoplasm
Pathways:
UniProt: Q7TN31
Entrez ID: 66549
|
Does Knockout of Negr1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Negr1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Negr1 (neuronal growth regulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cell adhesion, cell-cell adhesion, cholesterol homeostasis, fat cell differentiation, feeding behavior, lipid droplet formation, locomotory behavior, negative regulation of glial cell proliferation, negative regulation of synapse assembly, neuron projection morphogenesis, positive regulation of calcium-mediated signaling, positive regulation of neuron projection development, positive regulation of saliva secretion, protein localization to plasma membrane raft, protein secretion, regulation of protein stability, regulation of synapse assembly, skeletal muscle organ development, social behavior; CC: apical dendrite, dendrite, dendritic shaft, dendritic spine, late endosome, membrane, neuronal cell body, plasma membrane, postsynaptic density, side of membrane
Pathways: Cell adhesion molecules - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q80Z24
Entrez ID: 320840
|
Does Knockout of Prepl in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Prepl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prepl (prolyl endopeptidase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, proteolysis, regulation of synaptic vesicle exocytosis, retrograde transport, endosome to Golgi; MF: hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: Golgi apparatus, cytoplasm, cytoskeleton, cytosol, nucleus, trans-Golgi network
Pathways:
UniProt: Q8C167
Entrez ID: 213760
|
Does Knockout of Ptpdc1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ptpdc1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ptpdc1 (protein tyrosine phosphatase domain containing 1)
Type: protein-coding
Summary: The protein encoded by this gene is a centrosomal mitotic phosphatase. This protein has been implicated in centrosomal duplication and cytokinesis. In addition, knockdown of expression levels in non-cycling cells results in extra long cilia, suggesting that this protein may function in regulating cilia length independent of a function in cell cycle control. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: cell projection organization, cilium assembly, smoothened signaling pathway; MF: hydrolase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways:
UniProt: Q6NZK8
Entrez ID: 218232
|
Does Knockout of Mcat in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Mcat
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mcat (malonyl CoA:ACP acyltransferase (mitochondrial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, mitochondrial small ribosomal subunit assembly, monocarboxylic acid metabolic process; MF: [acyl-carrier-protein] S-malonyltransferase activity, transferase activity; CC: mitochondrion
Pathways: Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation
UniProt: Q8R3F5
Entrez ID: 223722
|
Does Knockout of Hadha in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Hadha
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Hadha (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiolipin acyl-chain remodeling, fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process, response to insulin, response to xenobiotic stimulus; MF: (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity, 3-hydroxyacyl-CoA dehydratase activity, NAD binding, NAD+ binding, acetyl-CoA C-acyltransferase activity, catalytic activity, enoyl-CoA hydratase activity, fatty-acyl-CoA binding, long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity, long-chain fatty acyl-CoA hydrolase activity, lyase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein binding, protein-containing complex binding, transferase activity; CC: membrane, mitochondrial fatty acid beta-oxidation multienzyme complex, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrion
Pathways: 3-oxoadipate degradation, Acyl chain remodeling of CL, Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA, Beta oxidation of hexanoyl-CoA to butanoyl-CoA, Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA, Beta oxidation of myristoyl-CoA to lauroyl-CoA, Beta oxidation of octanoyl-CoA to hexanoyl-CoA, Beta oxidation of palmitoyl-CoA to myristoyl-CoA, Butanoate metabolism - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Glycerophospholipid biosynthesis, Lysine degradation - Mus musculus (mouse), Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, Phospholipid metabolism, Propanoate metabolism - Mus musculus (mouse), Tryptophan metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse), fatty acid β-oxidation I, fatty acid β-oxidation II (core pathway), fatty acid β-oxidation IV (unsaturated, even number), mitochondrial fatty acid beta-oxidation of saturated fatty acids
UniProt: Q8BMS1
Entrez ID: 97212
|
Does Knockout of Cnga3 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Cnga3
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Cnga3 (cyclic nucleotide gated channel alpha 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, inorganic cation import across plasma membrane, membrane depolarization, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, response to cAMP, response to magnesium ion, retina development in camera-type eye, retinal cone cell development, sodium ion transmembrane transport, sodium ion transport, transmembrane transport, visual perception; MF: cGMP binding, cadherin binding, calcium channel activity, intracellularly cAMP-activated cation channel activity, intracellularly cGMP-activated cation channel activity, intracellularly cyclic nucleotide-activated monoatomic cation channel activity, monoatomic ion channel activity, myosin binding, nucleotide binding, protein binding, sodium channel activity; CC: axon initial segment, cone photoreceptor outer segment, dendrite, glial cell projection, intracellular cyclic nucleotide activated cation channel complex, membrane, neuronal cell body, non-motile cilium, perikaryon, photoreceptor outer segment, plasma membrane, transmembrane transporter complex
Pathways: Olfactory transduction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q9JJZ8
Entrez ID: 12790
|
Does Knockout of Ccdc85b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ccdc85b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ccdc85b (coiled-coil domain containing 85B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, negative regulation of cell growth, negative regulation of fat cell differentiation; MF: delta-catenin binding, protein binding; CC: adherens junction, anchoring junction, centrosome, cytoplasm, cytoskeleton, nucleus
Pathways:
UniProt: Q6PDY0
Entrez ID: 240514
|
Does Knockout of Fbll1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Fbll1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fbll1 (fibrillarin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst hatching, box C/D sno(s)RNA 3'-end processing, chromatin remodeling, mRNA stabilization, methylation, rRNA methylation, rRNA processing; MF: RNA 2'-O-methyltransferase activity, RNA binding, histone H2AQ104 methyltransferase activity, methyltransferase activity, rRNA methyltransferase activity, transferase activity; CC: Cajal body, box C/D methylation guide snoRNP complex, fibrillar center, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, small-subunit processome
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q80WS3
Entrez ID: 237730
|
Does Knockout of P3h3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
P3h3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: P3h3 (prolyl 3-hydroxylase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen biosynthetic process, collagen metabolic process, negative regulation of cell population proliferation, peptidyl-lysine hydroxylation; MF: L-ascorbic acid binding, dioxygenase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, procollagen-proline 3-dioxygenase activity, protein binding; CC: catalytic complex, endoplasmic reticulum
Pathways: Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization
UniProt: Q8CG70
Entrez ID: 14789
|
Does Knockout of Lactbl1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Lactbl1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lactbl1 (lactamase, beta-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: S4R213
Entrez ID: 242707
|
Does Knockout of Phc3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Phc3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Phc3 (polyhomeotic 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, chromatin binding, histone binding, metal ion binding, zinc ion binding; CC: PRC1 complex, PcG protein complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of RNA binding proteins, SUMOylation of chromatin organization proteins, SUMOylation of transcription cofactors, Transcriptional Regulation by E2F6, Transcriptional regulation by RUNX1
UniProt: Q8CHP6
Entrez ID: 241915
|
Does Knockout of Fat1 in Malignant Peripheral Nerve Sheath Tumor (MPNST) cancer cell causally result in tumorigenicity?
| 0
| 2,184
|
Knockout
|
Fat1
|
tumorigenicity
|
Malignant Peripheral Nerve Sheath Tumor (MPNST) cancer cell
|
Gene: Fat1 (FAT atypical cadherin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, anatomical structure morphogenesis, camera-type eye development, camera-type eye morphogenesis, cell adhesion, cell-cell adhesion, cell-cell adhesion mediated by cadherin, epithelial cell morphogenesis, establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis, establishment or maintenance of cell polarity, establishment or maintenance of epithelial cell apical/basal polarity, homophilic cell adhesion via plasma membrane adhesion molecules, lens development in camera-type eye, neuron migration, positive regulation of vascular associated smooth muscle cell migration; MF: calcium ion binding, protein binding; CC: adherens junction, apical plasma membrane, cell junction, cell-cell junction, cytosol, filopodium, lamellipodium, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: A0A087WRT4, F2Z4A3, A0A1L1SQU7, A0A087WPU4
Entrez ID: 14107
|
Does Knockout of Cdkl2 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Cdkl2
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Cdkl2 (cyclin dependent kinase like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q9QUK0
Entrez ID: 53886
|
Does Knockout of Med12l in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Med12l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Med12l (mediator complex subunit 12-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: beta-catenin binding, transcription coactivator activity, transcription coregulator activity; CC: mediator complex, nucleus
Pathways: Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: Q8BQM9
Entrez ID: 329650
|
Does Knockout of Usp7 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Usp7
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Usp7 (ubiquitin specific peptidase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA alkylation repair, DNA damage response, DNA repair, TORC1 signaling, autophagosome assembly, cellular response to nutrient levels, monoubiquitinated protein deubiquitination, negative regulation of TORC1 signaling, negative regulation of autophagy, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of gluconeogenesis, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of apoptotic process, positive regulation of autophagy, protein deubiquitination, protein stabilization, proteolysis, regulation of DNA-binding transcription factor activity, regulation of circadian rhythm, regulation of establishment of protein localization to telomere, regulation of protein stability, regulation of retrograde transport, endosome to Golgi, rhythmic process, symbiont-mediated disruption of host cell PML body, transcription elongation-coupled chromatin remodeling, transcription-coupled nucleotide-excision repair; MF: K48-linked deubiquitinase activity, cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, identical protein binding, p53 binding, peptidase activity, protein binding; CC: PML body, XY body, chromosome, cytoplasm, cytosol, nucleus, protein-containing complex
Pathways: DNA Repair, Deubiquitination, Dual incision in TC-NER, Epstein-Barr virus infection - Mus musculus (mouse), Formation of TC-NER Pre-Incision Complex, FoxO signaling pathway - Mus musculus (mouse), Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, Metabolism of proteins, Nucleotide Excision Repair, PIP3 activates AKT signaling, PTEN Regulation, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Transcription, Regulation of PTEN localization, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Signal Transduction, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Ub-specific processing proteases, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q6A4J8
Entrez ID: 252870
|
Does Knockout of Duox2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Duox2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Duox2 (dual oxidase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenohypophysis morphogenesis, bone mineralization, cellular oxidant detoxification, cytokine-mediated signaling pathway, defense response, fertilization, hormone biosynthetic process, hormone metabolic process, hydrogen peroxide biosynthetic process, hydrogen peroxide catabolic process, inner ear development, multicellular organism growth, positive regulation of cell motility, positive regulation of wound healing, response to cAMP, response to oxidative stress, response to virus, superoxide anion generation, thyroid gland development, thyroid hormone generation, thyroid hormone metabolic process; MF: NAD(P)H oxidase H2O2-forming activity, calcium ion binding, heme binding, metal ion binding, oxidoreductase activity, peroxidase activity, superoxide-generating NAD(P)H oxidase activity; CC: NADPH oxidase complex, apical part of cell, apical plasma membrane, cell leading edge, cell surface, cytosol, endoplasmic reticulum, membrane, plasma membrane
Pathways: Metabolism, Metabolism of amine-derived hormones, Metabolism of amino acids and derivatives, Thyroid hormone synthesis - Mus musculus (mouse), Thyroxine biosynthesis
UniProt: A2AQ99, A0A494BAW1
Entrez ID: 214593
|
Does Knockout of Slco2a1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Slco2a1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slco2a1 (solute carrier organic anion transporter family, member 2a1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid transport, prostaglandin transport, sodium-independent organic anion transport, transmembrane transport; MF: lipid transporter activity, prostaglandin transmembrane transporter activity, sodium-independent organic anion transmembrane transporter activity, transmembrane transporter activity; CC: basal plasma membrane, basolateral plasma membrane, cytoplasm, lysosome, membrane, plasma membrane
Pathways: Organic anion transport by SLCO transporters, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: Q9EPT5
Entrez ID: 24059
|
Does Knockout of Phf23 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Phf23
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Phf23 (PHD finger protein 23)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; and limb. Orthologous to human PHF23 (PHD finger protein 23). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: autophagy, negative regulation of autophagosome assembly, negative regulation of autophagosome maturation, positive regulation of protein ubiquitination; MF: metal ion binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8BSN5
Entrez ID: 78246
|
Does Knockout of Aplnr in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Aplnr
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Aplnr (apelin receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adult heart development, angiogenesis, aorta development, apelin receptor signaling pathway, atrioventricular valve development, blood vessel development, coronary vasculature development, endocardial cushion formation, gastrulation, heart development, heart looping, negative regulation of cAMP-mediated signaling, negative regulation of gene expression, positive regulation of G protein-coupled receptor internalization, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, positive regulation of release of sequestered calcium ion into cytosol, regulation of body fluid levels, regulation of gap junction assembly, regulation of gene expression, signal transduction, vascular associated smooth muscle cell differentiation, vasculature development, vasculogenesis, venous blood vessel development, ventricular septum morphogenesis; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, apelin receptor activity, mechanoreceptor activity; CC: membrane, plasma membrane
Pathways: Apelin signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q9WV08
Entrez ID: 23796
|
Does Knockout of Cmas in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Cmas
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cmas (cytidine monophospho-N-acetylneuraminic acid synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP-N-acetylneuraminate biosynthetic process, N-acetylneuraminate metabolic process, glycosylation; MF: N-acylneuraminate cytidylyltransferase activity, nucleotidyltransferase activity, transferase activity; CC: nucleoplasm, nucleus
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, Post-translational protein modification, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis
UniProt: Q99KK2
Entrez ID: 12764
|
Does Knockout of Gmps in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Gmps
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gmps (guanine monophosphate synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GMP biosynthetic process, GMP salvage, purine nucleotide biosynthetic process, response to L-cysteine; MF: ATP binding, GMP synthase (glutamine-hydrolyzing) activity, GMP synthase activity, enzyme binding, ligase activity, nucleotide binding; CC: cytoplasm, cytosol
Pathways: Azathioprine ADME, Drug ADME, Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis
UniProt: Q3THK7
Entrez ID: 229363
|
Does Knockout of Pde6h in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Pde6h
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pde6h (phosphodiesterase 6H, cGMP-specific, cone, gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of epidermal growth factor receptor signaling pathway, visual perception; MF: 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cGMP binding, hydrolase activity
Pathways: Purine metabolism - Mus musculus (mouse)
UniProt: P61249
Entrez ID: 78600
|
Does Knockout of Izumo4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Izumo4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Izumo4 (IZUMO family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: Acrosome Reaction and Sperm:Oocyte Membrane Binding, Fertilization, Reproduction
UniProt: D3Z690
Entrez ID: 71564
|
Does Knockout of Otol1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Otol1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Otol1 (otolin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: otolith mineralization, protein homooligomerization; MF: calcium ion binding, metal ion binding, protein binding; CC: collagen trimer, extracellular region
Pathways:
UniProt: Q4ZJM7
Entrez ID: 229389
|
Does Knockout of Dnah7b in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Dnah7b
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Dnah7b (dynein, axonemal, heavy chain 7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium movement, cilium movement involved in cell motility, inner dynein arm assembly, microtubule-based movement; MF: ATP binding, calcium ion binding, dynein intermediate chain binding, dynein light intermediate chain binding, minus-end-directed microtubule motor activity, nucleotide binding; CC: 9+2 motile cilium, axonemal dynein complex, cell projection, cilium, cytoplasm, cytoskeleton, dynein complex, inner dynein arm, microtubule, motile cilium
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse)
UniProt: A0A087WPC9, A0A571BD48, L7N1Y0
Entrez ID: 227058
|
Does Knockout of Vmn1r205 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Vmn1r205
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vmn1r205 (vomeronasal 1 receptor 205)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R276
Entrez ID: 171251
|
Does Knockout of Nsun4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Nsun4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Nsun4 (NOL1/NOP2/Sun domain family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial RNA catabolic process, mitochondrial RNA modification, rRNA methylation, tRNA methylation; MF: RNA methyltransferase activity, mRNA (cytidine-5-)-methyltransferase activity, rRNA (cytosine-C5-)-methyltransferase activity, rRNA methyltransferase activity, tRNA (cytidine-5-)-methyltransferase activity, tRNA binding; CC: cytoplasm, mitochondrial matrix, mitochondrion, nucleus
Pathways:
UniProt: C4P6S0, Q9CZ57
Entrez ID: 72181
|
Does Knockout of Rps14 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 1
| 2,474
|
Knockout
|
Rps14
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Rps14 (ribosomal protein S14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, erythrocyte differentiation, maturation of SSU-rRNA, negative regulation of transcription by RNA polymerase II, ribosomal small subunit assembly, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, mRNA 5'-UTR binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, mitochondrion, nucleolus, nucleus, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62264
Entrez ID: 20044
|
Does Knockout of Tubgcp6 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Tubgcp6
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Tubgcp6 (tubulin, gamma complex component 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, spindle assembly; MF: gamma-tubulin binding, microtubule binding, microtubule minus-end binding; CC: centrosome, cytoplasm, cytoskeleton, gamma-tubulin complex, gamma-tubulin ring complex, microtubule, microtubule organizing center, spindle pole
Pathways: Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes
UniProt: G5E8P0
Entrez ID: 328580
|
Does Knockout of Cd2bp2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Cd2bp2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cd2bp2 (CD2 cytoplasmic tail binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing; MF: ribonucleoprotein complex binding; CC: U5 snRNP, cytoplasm, cytosol, fibrillar center, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q9CWK3
Entrez ID: 70233
|
Does Knockout of Pnkp in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Pnkp
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pnkp (polynucleotide kinase 3'- phosphatase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via nonhomologous end joining, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of telomere maintenance, protein K63-linked ubiquitination, response to oxidative stress; MF: ATP binding, ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity, ATP-dependent polynucleotide 5'-hydroxyl-kinase activity, catalytic activity, hydrolase activity, kinase activity, nucleotide binding, polynucleotide 3'-phosphatase activity, transferase activity, ubiquitin-like ligase-substrate adaptor activity; CC: SCF ubiquitin ligase complex, nucleolus, nucleoplasm, nucleus, site of double-strand break
Pathways:
UniProt: E9Q9A5, G5E8N7, A0A0J9YUT2, A0A0J9YVH5, A0A140LIZ1, A0A0J9YUF9, A0A0J9YTV1, D3YZV7, A0A0J9YV48, A0A0J9YVJ6, A0A140LJ53
Entrez ID: 59047
|
Does Knockout of Nip7 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Nip7
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nip7 (NIP7, nucleolar pre-rRNA processing protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome assembly, ribosome biogenesis; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CXK8
Entrez ID: 66164
|
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