prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Snrk in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Snrk
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Snrk (SNF related kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: nucleus
Pathways:
UniProt: Q8VDU5
Entrez ID: 20623
|
Does Knockout of Psmg1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Psmg1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Psmg1 (proteasome (prosome, macropain) assembly chaperone 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellar granule cell precursor proliferation, chaperone-mediated protein complex assembly, proteasome assembly, proteasome core complex assembly; MF: molecular adaptor activity, proteasome binding; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum, nucleoplasm, protein folding chaperone complex
Pathways: Metabolism of proteins, Post-translational protein modification, Proteasome assembly
UniProt: Q9JK23
Entrez ID: 56088
|
Does Knockout of Rad54l in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,525
|
Knockout
|
Rad54l
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rad54l (RAD54 like (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromosome organization, determination of adult lifespan, double-strand break repair, double-strand break repair via homologous recombination, double-strand break repair via synthesis-dependent strand annealing, reciprocal meiotic recombination, response to ionizing radiation, response to xenobiotic stimulus; MF: ATP binding, ATP hydrolysis activity, ATP-dependent DNA/DNA annealing activity, DNA binding, DNA translocase activity, helicase activity, hydrolase activity, metal ion binding, nucleotide binding; CC: nucleoplasm, nucleus, protein-containing complex
Pathways: Homologous recombination - Mus musculus (mouse)
UniProt: P70270
Entrez ID: 19366
|
Does Knockout of Usp40 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Usp40
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Usp40 (ubiquitin specific peptidase 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: cytosol, nucleus
Pathways:
UniProt: Q8BWR4
Entrez ID: 227334
|
Does Knockout of Lrrc3 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Lrrc3
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Lrrc3 (leucine rich repeat containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: P59034
Entrez ID: 237387
|
Does Knockout of Trerf1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Trerf1
|
phagocytosis
|
macrophage
|
Gene: Trerf1 (transcriptional regulating factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to progesterone stimulus, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, progesterone receptor signaling pathway, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, nuclear progesterone receptor binding, transcription coactivator activity, transcription coactivator binding, transcription corepressor activity, zinc ion binding; CC: cytosol, fibrillar center, histone deacetylase complex, nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q8BXJ2
Entrez ID: 224829
|
Does Knockout of Lrrc75a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Lrrc75a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lrrc75a (leucine rich repeat containing 75A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q7TSF4
Entrez ID: 192976
|
Does Knockout of Gm3055 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Gm3055
|
response to virus
|
Microglial Cell Line
|
Gene: Gm3055 (predicted gene 3055)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt:
Entrez ID: 100040944
|
Does Knockout of Mir8094 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Mir8094
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Mir8094 (microRNA 8094)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465886
|
Does Knockout of Tas2r114 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Tas2r114
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Tas2r114 (taste receptor, type 2, member 114)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity; CC: membrane
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: Q7M722
Entrez ID: 387346
|
Does Knockout of 1700030J22Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
1700030J22Rik
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: 1700030J22Rik (RIKEN cDNA 1700030J22 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytosol, nucleoplasm
Pathways:
UniProt: Q8BHB7
Entrez ID: 69528
|
Does Knockout of Kremen2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Kremen2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Kremen2 (kringle containing transmembrane protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, limb development, negative regulation of ossification, signal transduction; MF: protein binding, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q8K1S7
Entrez ID: 73016
|
Does Knockout of Wdr1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Wdr1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Wdr1 (WD repeat domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament depolymerization, actin filament fragmentation, apical junction assembly, cortical cytoskeleton organization, establishment of planar polarity of follicular epithelium, locomotion, maintenance of epithelial cell apical/basal polarity, neutrophil mediated immunity, neutrophil migration, platelet formation, positive regulation of actin filament depolymerization, regulation of actin filament depolymerization, regulation of cell shape, regulation of oligodendrocyte differentiation, regulation of ventricular cardiac muscle cell membrane repolarization, sarcomere organization, sensory perception of sound; MF: actin binding, actin filament binding; CC: actin cytoskeleton, anchoring junction, cell junction, cell projection, cell-cell junction, cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, glutamatergic synapse, myelin sheath, plasma membrane, podosome, synapse
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: O88342
Entrez ID: 22388
|
Does Knockout of Arl13b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Arl13b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Arl13b (ADP-ribosylation factor-like 13B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, determination of left/right symmetry, dorsal/ventral pattern formation, formation of radial glial scaffolds, heart looping, interneuron migration from the subpallium to the cortex, left/right axis specification, neural tube patterning, non-motile cilium assembly, receptor localization to non-motile cilium, smoothened signaling pathway; MF: GTP binding, GTPase activity, nucleotide binding, protein binding; CC: axoneme, cell projection, ciliary basal body, ciliary membrane, cilium, cytosol, intercellular bridge, membrane, microtubule cytoskeleton, motile cilium, non-motile cilium, plasma membrane
Pathways: ARL13B-mediated ciliary trafficking of INPP5E, Aggrephagy, Autophagy, Cargo trafficking to the periciliary membrane, Cilium Assembly, Macroautophagy, Organelle biogenesis and maintenance, RHO GTPase cycle, RHOQ GTPase cycle, Selective autophagy, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q640N2
Entrez ID: 68146
|
Does Knockout of Mthfd2l in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Mthfd2l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mthfd2l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 10-formyltetrahydrofolate metabolic process, amino acid biosynthetic process, carboxylic acid metabolic process, methionine biosynthetic process, one-carbon metabolic process, purine nucleotide biosynthetic process, tetrahydrofolate interconversion; MF: catalytic activity, hydrolase activity, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, oxidoreductase activity; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Metabolism, Metabolism of folate and pterines, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, One carbon pool by folate - Mus musculus (mouse), folate transformations I, folate transformations II (plants)
UniProt: D3YZG8
Entrez ID: 665563
|
Does Knockout of Dolk in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 616
|
Knockout
|
Dolk
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Dolk (dolichol kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol phosphate mannose biosynthetic process, dolichyl monophosphate biosynthetic process, lipid metabolic process, protein N-linked glycosylation; MF: dolichol kinase activity, kinase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Synthesis of dolichyl-phosphate, Synthesis of substrates in N-glycan biosythesis
UniProt: Q8R2Y3
Entrez ID: 227697
|
Does Knockout of Hif1a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Hif1a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hif1a (hypoxia inducible factor 1, alpha subunit)
Type: protein-coding
Summary: This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: B-1 B cell homeostasis, angiogenesis, axonal transport of mitochondrion, blood vessel development, blood vessel morphogenesis, camera-type eye morphogenesis, cardiac ventricle morphogenesis, cartilage development, cell differentiation, cellular response to hypoxia, cellular response to interleukin-1, cellular response to oxidative stress, cellular response to virus, cerebral cortex development, chondrocyte differentiation, collagen metabolic process, connective tissue replacement involved in inflammatory response wound healing, digestive tract morphogenesis, dopaminergic neuron differentiation, elastin metabolic process, embryonic hemopoiesis, embryonic placenta development, epithelial cell differentiation involved in mammary gland alveolus development, epithelial cell maturation, epithelial to mesenchymal transition, glandular epithelial cell differentiation, glandular epithelial cell maturation, glucose homeostasis, heart looping, hemoglobin biosynthetic process, hypoxia-inducible factor-1alpha signaling pathway, intestinal epithelial cell maturation, intracellular glucose homeostasis, intracellular iron ion homeostasis, intracellular oxygen homeostasis, iris morphogenesis, iron import into the mitochondrion, lactate metabolic process, lactation, muscle cell cellular homeostasis, negative regulation of TOR signaling, negative regulation of apoptotic process, negative regulation of bone mineralization, negative regulation of gene expression, negative regulation of growth, negative regulation of mesenchymal cell apoptotic process, negative regulation of miRNA transcription, negative regulation of neuron apoptotic process, negative regulation of ossification, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of reactive oxygen species biosynthetic process, negative regulation of thymocyte apoptotic process, negative regulation of transcription by RNA polymerase II, negative regulation of vasoconstriction, neural crest cell migration, neural fold elevation formation, outflow tract morphogenesis, positive regulation of DNA-templated transcription, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of blood vessel endothelial cell migration, positive regulation of cell population proliferation, positive regulation of chemokine-mediated signaling pathway, positive regulation of cytokine production involved in inflammatory response, positive regulation of endothelial cell migration, positive regulation of epithelial cell migration, positive regulation of erythrocyte differentiation, positive regulation of gene expression, positive regulation of gluconeogenesis, positive regulation of glycolytic process, positive regulation of hormone biosynthetic process, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of macroautophagy, positive regulation of miRNA transcription, positive regulation of multicellular organismal process, positive regulation of neuroblast proliferation, positive regulation of smooth muscle cell proliferation, positive regulation of sprouting angiogenesis, positive regulation of stress granule assembly, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial growth factor production, positive regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of vascular wound healing, regulation of DNA-templated transcription, regulation of cell population proliferation, regulation of gene expression, regulation of glycolytic process, regulation of protein neddylation, regulation of thymocyte apoptotic process, regulation of transcription by RNA polymerase II, regulation of transforming growth factor beta2 production, response to fungicide, response to hypoxia, response to iron ion, response to muscle activity, response to oxidative stress, response to reactive oxygen species, retina vasculature development in camera-type eye, signal transduction, tissue remodeling, vascular endothelial growth factor production, vasculature development, visual learning; MF: DNA binding, DNA-binding transcription activator activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, E-box binding, Hsp90 protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cis-regulatory region sequence-specific DNA binding, enzyme binding, histone deacetylase binding, nuclear receptor binding, p53 binding, protein binding, protein dimerization activity, protein domain specific binding, protein heterodimerization activity, protein kinase binding, protein-containing complex binding, sequence-specific DNA binding, transcription coactivator binding, transcription corepressor binding, transcription regulator activator activity, ubiquitin protein ligase binding; CC: RNA polymerase II transcription regulator complex, axon cytoplasm, chromatin, cytoplasm, cytosol, euchromatin, motile cilium, nuclear body, nuclear speck, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: Autophagy - animal - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: Q61221
Entrez ID: 15251
|
Does Knockout of Tnip3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Tnip3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tnip3 (TNFAIP3 interacting protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MyD88-independent toll-like receptor signaling pathway, cellular response to lipopolysaccharide, negative regulation of canonical NF-kappaB signal transduction, regulation of canonical NF-kappaB signal transduction, regulation of transcription by RNA polymerase II, toll-like receptor 4 signaling pathway
Pathways: Deubiquitination, Metabolism of proteins, Ovarian tumor domain proteases, Post-translational protein modification
UniProt: A0A1D5RMN0, Q3SXA6, A0A1D5RLN9
Entrez ID: 414084
|
Does Knockout of Ddx55 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ddx55
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ddx55 (DEAD box helicase 55)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, large ribosomal subunit rRNA binding, nucleic acid binding, nucleotide binding, rRNA binding; CC: cytosol, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q6ZPL9
Entrez ID: 67848
|
Does Knockout of Clec4b1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Clec4b1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Clec4b1 (C-type lectin domain family 4, member b1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, antifungal innate immune response, immune system process, innate immune response, positive regulation of release of sequestered calcium ion into cytosol; MF: carbohydrate binding, metal ion binding, pattern recognition receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse)
UniProt: Q9D8Q7, Q7TS58
Entrez ID: 69810
|
Does Knockout of C2cd4c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
C2cd4c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: C2cd4c (C2 calcium-dependent domain containing 4C)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5HZI2
Entrez ID: 237397
|
Does Knockout of Cartpt in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Cartpt
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cartpt (CART prepropeptide)
Type: protein-coding
Summary: This gene encodes preproprotein isoforms that are processed into multiple biologically active peptides. Expression of this gene is regulated by cocaine and other drugs, and is associated with feeding/appetite and stress response. Mice lacking the encoded protein are predisposed to obesity. Deficiency of the encoded protein in mice results in pancreatic islet dysfunction, impaired insulin secretion and glucose intolerance. Alternative splicing results in multiple transcript variants encoding different isoforms, which are subsequently processed into mature peptides. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adult feeding behavior, behavioral response to cocaine, cAMP biosynthetic process, cellular response to estradiol stimulus, cellular response to starvation, chemical synaptic transmission, circadian regulation of gene expression, circadian rhythm, conditioned place preference, detection of chemical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, drinking behavior, glucose metabolic process, intracellular calcium ion homeostasis, intracellular glucose homeostasis, negative regulation of D-glucose import, negative regulation of appetite, negative regulation of bone resorption, negative regulation of cytosolic calcium ion concentration, negative regulation of eating behavior, negative regulation of glucagon secretion, negative regulation of locomotion, negative regulation of osteoclast differentiation, negative regulation of relaxation of smooth muscle, negative regulation of type B pancreatic cell apoptotic process, neuropeptide signaling pathway, operant conditioning, positive regulation of MAPK cascade, positive regulation of blood pressure, positive regulation of cell communication, positive regulation of epinephrine secretion, positive regulation of exocytosis, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of transmission of nerve impulse, positive regulation of type B pancreatic cell proliferation, regulation of bone remodeling, regulation of circadian sleep/wake cycle, REM sleep, regulation of circadian sleep/wake cycle, non-REM sleep, regulation of circadian sleep/wake cycle, wakefulness, regulation of exocytosis, regulation of heart rate by chemical signal, regulation of insulin secretion, regulation of lipid biosynthetic process, regulation of lipid catabolic process, regulation of locomotion involved in locomotory behavior, regulation of systemic arterial blood pressure by neurotransmitter, response to corticosterone, response to corticotropin-releasing hormone, response to ethanol, response to food, response to glucocorticoid, response to glucose, response to insulin, response to morphine, response to starvation, signal transduction, somatostatin secretion; MF: neuropeptide hormone activity; CC: cytoplasm, extracellular region, extracellular space, neuronal cell body, secretory granule, synapse
Pathways:
UniProt: P56388
Entrez ID: 27220
|
Does Knockout of Taf12 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Taf12
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Taf12 (TATA-box binding protein associated factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase II preinitiation complex assembly, mRNA transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, protein binding, protein heterodimerization activity, transcription coactivator activity; CC: SAGA complex, nucleus, transcription factor TFIID complex, transcription factor TFTC complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q8VE65
Entrez ID: 66464
|
Does Knockout of Hps4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Hps4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Hps4 (HPS4, biogenesis of lysosomal organelles complex 3 subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood coagulation, lysosome organization, melanocyte differentiation, melanosome assembly, platelet dense granule organization, protein stabilization, protein targeting, vesicle-mediated transport; MF: guanyl-nucleotide exchange factor activity, protein dimerization activity, protein homodimerization activity, small GTPase binding; CC: BLOC-3 complex, cytoplasm, cytoplasmic vesicle, lysosomal membrane, lysosome, melanosome, membrane, platelet dense granule
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q99KG7
Entrez ID: 192232
|
Does Knockout of Cdk5rap3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Cdk5rap3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cdk5rap3 (CDK5 regulatory subunit associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic nuclear changes, cell population proliferation, definitive erythrocyte differentiation, endoplasmic reticulum unfolded protein response, liver development, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, negative regulation of MAP kinase activity, negative regulation of NF-kappaB transcription factor activity, negative regulation of protein catabolic process, negative regulation of protein kinase activity by regulation of protein phosphorylation, negative regulation of protein phosphorylation, negative regulation of protein serine/threonine kinase activity, positive regulation of protein localization to nucleus, positive regulation of protein ubiquitination, positive regulation of proteolysis involved in protein catabolic process, positive regulation of reticulophagy, positive regulation of signal transduction by p53 class mediator, positive regulation of transcription by RNA polymerase II, positive regulation of ubiquitin-dependent protein catabolic process, protein ufmylation, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of mitotic cell cycle, regulation of phosphatase activity, rescue of stalled ribosome, response to endoplasmic reticulum stress, ribosome disassembly; MF: MDM2/MDM4 family protein binding, NF-kappaB binding, cyclin binding, mitogen-activated protein kinase binding, protein binding, protein kinase binding, protein-containing complex binding, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-like protein ligase binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, microtubule, nucleolus, nucleus, protein-containing complex
Pathways:
UniProt: Q99LM2
Entrez ID: 80280
|
Does Knockout of Ube2i in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Ube2i
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ube2i (ubiquitin-conjugating enzyme E2I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, chromosome segregation, modulation of chemical synaptic transmission, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, nuclear export, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, positive regulation of intracellular steroid hormone receptor signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein modification process, protein sumoylation; MF: ATP binding, HLH domain binding, RING-like zinc finger domain binding, SUMO conjugating enzyme activity, SUMO transferase activity, bHLH transcription factor binding, enzyme binding, ionotropic glutamate receptor binding, nucleotide binding, protein binding, small protein activating enzyme binding, transcription coregulator binding, transferase activity, ubiquitin-protein transferase activity; CC: PML body, SUMO ligase complex, Schaffer collateral - CA1 synapse, cytoplasm, cytosol, dendrite, fibrillar center, glutamatergic synapse, nuclear body, nuclear envelope, nuclear pore, nucleoplasm, nucleus, postsynaptic cytosol, presynaptic cytosol, transferase complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Developmental Biology, Formation of Incision Complex in GG-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, M Phase, MITF-M-regulated melanocyte development, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, MicroRNAs in cancer - Mus musculus (mouse), Mitotic Anaphase, Mitotic Metaphase and Anaphase, NF-kappa B signaling pathway - Mus musculus (mouse), Negative regulation of activity of TFAP2 (AP-2) family transcription factors, Nuclear Envelope (NE) Reassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Nucleotide Excision Repair, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing and activation of SUMO, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, SUMO E3 ligases SUMOylate target proteins, SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA methylation proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of immune response proteins, SUMOylation of intracellular receptors, SUMOylation of nuclear envelope proteins, SUMOylation of transcription cofactors, SUMOylation of transcription factors, SUMOylation of ubiquitinylation proteins, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Ubiquitin mediated proteolysis - Mus musculus (mouse), Vitamin D (calciferol) metabolism
UniProt: P63280
Entrez ID: 22196
|
Does Knockout of Gm28051 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Gm28051
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm28051 (predicted gene, 28051)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Flad1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Flad1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Flad1 (flavin adenine dinucleotide synthetase 1)
Type: protein-coding
Summary: Enables FMN adenylyltransferase activity. Involved in flavin adenine dinucleotide biosynthetic process and riboflavin metabolic process. Is active in cytosol. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: FAD biosynthetic process, flavin adenine dinucleotide biosynthetic process, riboflavin metabolic process; MF: ATP binding, FAD diphosphatase activity, FMN adenylyltransferase activity, catalytic activity, identical protein binding, nucleotide binding, nucleotidyltransferase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrial matrix, nucleus, plasma membrane
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Riboflavin metabolism - Mus musculus (mouse), Vitamin B2 (riboflavin) metabolism, flavin biosynthesis IV (mammalian), riboflavin, FMN and FAD transformations
UniProt: Q8R123
Entrez ID: 319945
|
Does Knockout of Fgf17 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Fgf17
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fgf17 (fibroblast growth factor 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fibroblast growth factor receptor signaling pathway, neurogenesis, positive regulation of MAPK cascade, positive regulation of cell population proliferation, regulation of cell migration; MF: growth factor activity, type 1 fibroblast growth factor receptor binding, type 2 fibroblast growth factor receptor binding; CC: cytoplasm, extracellular region, extracellular space
Pathways: Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, FGFR1 ligand binding and activation, FGFR1c ligand binding and activation, FGFR2 ligand binding and activation, FGFR2c ligand binding and activation, FGFR3 ligand binding and activation, FGFR3b ligand binding and activation, FGFR3c ligand binding and activation, FGFR4 ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Gastric cancer - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Phospholipase C-mediated cascade: FGFR1, Phospholipase C-mediated cascade; FGFR2, Phospholipase C-mediated cascade; FGFR3, Phospholipase C-mediated cascade; FGFR4, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: P63075
Entrez ID: 14171
|
Does Knockout of Ift43 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Ift43
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ift43 (intraflagellar transport 43)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, intraciliary retrograde transport; CC: cell projection, centriolar satellite, centriole, ciliary basal body, cilium, cytoplasm, cytoskeleton, intercellular bridge, intraciliary transport particle A, microtubule cytoskeleton, mitotic spindle
Pathways: Cilium Assembly, Intraflagellar transport, Organelle biogenesis and maintenance
UniProt: Q9DA69
Entrez ID: 76411
|
Does Knockout of Gbf1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Gbf1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gbf1 (golgi-specific brefeldin A-resistance factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPI coating of Golgi vesicle, Golgi disassembly, Golgi organization, Golgi to endosome transport, cell activation involved in immune response, cellular response to virus, endomembrane system organization, endoplasmic reticulum-Golgi intermediate compartment organization, endosomal transport, establishment of monopolar cell polarity, neutrophil chemotaxis, protein localization to Golgi apparatus, protein localization to endoplasmic reticulum exit site, protein localization to endoplasmic reticulum tubular network, protein transport, reactive oxygen species biosynthetic process, regulation of ARF protein signal transduction, regulation of mitotic cell cycle, regulation of protein localization to cell surface, retrograde transport, endosome to Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; MF: guanyl-nucleotide exchange factor activity, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, protein binding; CC: Golgi apparatus, Golgi apparatus subcompartment, Golgi membrane, Golgi stack, cell leading edge, cis-Golgi network, cytoplasm, cytosol, endoplasmic reticulum lumen, endoplasmic reticulum-Golgi intermediate compartment, lipid droplet, membrane, peroxisome, trans-Golgi network
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cargo trafficking to the periciliary membrane, Cilium Assembly, ER to Golgi Anterograde Transport, Endocytosis - Mus musculus (mouse), Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Organelle biogenesis and maintenance, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, VxPx cargo-targeting to cilium, trans-Golgi Network Vesicle Budding
UniProt: Q6DFZ1
Entrez ID: 107338
|
Does Knockout of Rptor in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Rptor
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rptor (regulatory associated protein of MTOR, complex 1)
Type: protein-coding
Summary: This gene encodes a subunit of mammalian target of rapamycin complex 1 (mTORC1), a component of the mTOR signaling pathway, which regulates cell growth in response to nutrient and energy levels. The encoded protein may regulate the assembly, localization, and substrate binding of the mTORC1 complex. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: DNA damage response, TOR signaling, TORC1 signaling, autophagosome assembly, cellular response to L-leucine, cellular response to amino acid stimulus, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to nutrient levels, cellular response to osmotic stress, cellular response to starvation, cytoplasmic translation, negative regulation of autophagy, negative regulation of insulin secretion, negative regulation of translational initiation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of cell growth, positive regulation of endothelial cell proliferation, positive regulation of glycolytic process, positive regulation of lipid biosynthetic process, positive regulation of odontoblast differentiation, positive regulation of osteoclast differentiation, positive regulation of pentose-phosphate shunt, positive regulation of transcription by RNA polymerase III, positive regulation of translational initiation, protein localization to lysosome, regulation of autophagy, regulation of biological quality, regulation of cell communication, regulation of cell growth, regulation of cell size, regulation of protein phosphorylation, regulation of signaling, response to xenobiotic stimulus, social behavior; MF: 14-3-3 protein binding, enzyme-substrate adaptor activity, protein binding, protein kinase activator activity, protein kinase binding, protein serine/threonine kinase inhibitor activity, protein-containing complex binding, protein-macromolecule adaptor activity, small GTPase binding; CC: TORC1 complex, cytoplasm, cytoplasmic stress granule, cytosol, dendrite, lysosomal membrane, lysosome, neuronal cell body, nucleoplasm, serine/threonine protein kinase complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: A4FUW1, A2ACM0, F7BQS0, F7B6I3, F7CN67, A0A991EQV1, F6U5L3, E9PXZ5
Entrez ID: 74370
|
Does Knockout of Gtf3a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Gtf3a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gtf3a (general transcription factor III A)
Type: protein-coding
Summary: The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome biogenesis; MF: 5S rRNA binding, DNA binding, RNA binding, RNA polymerase III general transcription initiation factor activity, metal ion binding, nucleic acid binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter
UniProt: Q8VHT7
Entrez ID: 66596
|
Does Knockout of Nol10 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Nol10
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nol10 (nucleolar protein 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleolus, nucleus, small-subunit processome
Pathways:
UniProt: Q5RJG1
Entrez ID: 217431
|
Does Knockout of Psd3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Psd3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Psd3 (pleckstrin and Sec7 domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ARF protein signal transduction, regulation of ARF protein signal transduction; MF: guanyl-nucleotide exchange factor activity; CC: cell junction, cell projection, cleavage furrow, glutamatergic synapse, membrane, plasma membrane, postsynapse, postsynaptic density, ruffle membrane, synapse
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q2PFD7
Entrez ID: 234353
|
Does Knockout of Hoxa1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Hoxa1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hoxa1 (homeobox A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: abducens nerve formation, anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, anterior/posterior pattern specification, artery development, artery morphogenesis, cellular response to ethanol, cellular response to retinoic acid, central nervous system neuron differentiation, cochlea development, cochlea morphogenesis, cognition, embryonic neurocranium morphogenesis, facial nerve structural organization, facial nucleus development, hindbrain development, inner ear development, inner ear morphogenesis, motor neuron axon guidance, nervous system development, neuromuscular process, optokinetic behavior, outer ear morphogenesis, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of behavior, regulation of transcription by RNA polymerase II, rhombomere 3 development, rhombomere 4 development, rhombomere 5 development, semicircular canal formation, sensory perception of sound; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways: Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: Q8BNI8, B9EHK7, D3Z4E1
Entrez ID: 15394
|
Does Knockout of Pfdn6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Pfdn6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pfdn6 (prefoldin subunit 6)
Type: protein-coding
Summary: Predicted to enable amyloid-beta binding activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone-mediated protein complex assembly; negative regulation of amyloid fibril formation; and protein folding. Predicted to be part of RPAP3/R2TP/prefoldin-like complex and prefoldin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human PFDN6 (prefoldin subunit 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chaperone-mediated protein complex assembly, negative regulation of amyloid fibril formation, protein folding; MF: amyloid-beta binding, protein binding, protein-folding chaperone binding, unfolded protein binding; CC: RPAP3/R2TP/prefoldin-like complex, cytoplasm, prefoldin complex
Pathways:
UniProt: Q03958
Entrez ID: 14976
|
Does Knockout of Edem1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Edem1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Edem1 (ER degradation enhancer, mannosidase alpha-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, carbohydrate metabolic process, endoplasmic reticulum mannose trimming, positive regulation of retrograde protein transport, ER to cytosol, protein targeting to ER, response to unfolded protein, ubiquitin-dependent protein catabolic process; MF: calcium ion binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity, misfolded protein binding, protein binding; CC: aggresome, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, membrane
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q925U4
Entrez ID: 192193
|
Does Knockout of Hyal1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Hyal1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hyal1 (hyaluronoglucosaminidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cartilage development, cellular response to UV-B, cellular response to fibroblast growth factor stimulus, cellular response to interleukin-1, cellular response to pH, cellular response to platelet-derived growth factor stimulus, cellular response to tumor necrosis factor, chondroitin sulfate proteoglycan catabolic process, embryonic skeletal joint morphogenesis, hyaluronan catabolic process, hyaluronan metabolic process, inflammatory response, negative regulation of cell growth, positive regulation of angiogenesis, positive regulation of cell adhesion, positive regulation of cell growth, positive regulation of hyaluranon cable assembly, response to antibiotic, response to reactive oxygen species, response to virus; MF: chondroitin hydrolase activity, hyalurononglucosaminidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, virus receptor activity; CC: cytoplasmic vesicle, extracellular region, extracellular space, hyaluranon cable, lysosome
Pathways: CS/DS degradation, Chondroitin sulfate/dermatan sulfate metabolism, Glycosaminoglycan degradation - Mus musculus (mouse), Glycosaminoglycan metabolism, Hyaluronan degradation, Hyaluronan metabolism, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q91ZJ9
Entrez ID: 15586
|
Does Knockout of Cdc14b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Cdc14b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cdc14b (CDC14 cell division cycle 14B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cilium assembly, microtubule cytoskeleton organization, mitotic G2 DNA damage checkpoint signaling, positive regulation of cytokinesis, positive regulation of ubiquitin protein ligase activity, protein dephosphorylation, regulation of exit from mitosis; MF: hydrolase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity; CC: cell junction, cytoplasm, cytosol, mitotic spindle, nucleolus, nucleoplasm, nucleus, spindle pole
Pathways: Cell cycle - Mus musculus (mouse), MAPK family signaling cascades, MAPK6/MAPK4 signaling, Signal Transduction
UniProt: Q6PFY9
Entrez ID: 218294
|
Does Knockout of Ankle2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ankle2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ankle2 (ankyrin repeat and LEM domain containing 2)
Type: protein-coding
Summary: Predicted to enable protein kinase inhibitor activity and protein phosphatase 2A binding activity. Predicted to be involved in several processes, including mitotic nuclear membrane reassembly; negative regulation of apoptotic process; and negative regulation of phosphorylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, central nervous system development, mitotic nuclear membrane reassembly, negative regulation of apoptotic process, negative regulation of phosphorylation, nervous system development, nuclear membrane reassembly; MF: protein kinase inhibitor activity, protein phosphatase 2A binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Cell Cycle, Cell Cycle, Mitotic, Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Nuclear Envelope (NE) Reassembly, RAC2 GTPase cycle, RHO GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6P1H6
Entrez ID: 71782
|
Does Knockout of Rpl31 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Rpl31
|
response to virus
|
Microglial Cell Line
|
Gene: Rpl31 (ribosomal protein L31)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation; MF: protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, nucleoplasm, postsynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62900
Entrez ID: 114641
|
Does Knockout of Akirin2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Akirin2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Akirin2 (akirin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, cerebral cortex development, defense response to bacterium, embryo development ending in birth or egg hatching, immune system process, innate immune response, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, nuclear protein quality control by the ubiquitin-proteasome system, positive regulation of B cell activation, positive regulation of adaptive immune response, positive regulation of cell population proliferation, positive regulation of innate immune response, positive regulation of interleukin-6 production, positive regulation of transcription by RNA polymerase II, proteasomal protein catabolic process, proteasome localization, protein import into nucleus, protein transport, regulation of muscle cell differentiation, response to lipopolysaccharide; MF: enzyme binding, identical protein binding, protein binding, protein-macromolecule adaptor activity, transcription coregulator activity; CC: chromatin, cytoplasm, membrane, nucleoplasm, nucleus, transcription repressor complex
Pathways:
UniProt: B1AXD8
Entrez ID: 433693
|
Does Knockout of Snrpa1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Snrpa1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Snrpa1 (small nuclear ribonucleoprotein polypeptide A')
Type: protein-coding
Summary: Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and spermatogenesis. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Is expressed in several structures, including central nervous system; hemolymphoid system; liver; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spermatogenesis; MF: RNA binding, U2 snRNA binding; CC: U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, nuclear body, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P57784
Entrez ID: 68981
|
Does Knockout of Fadd in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Fadd
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fadd (Fas associated via death domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, T cell differentiation in thymus, T cell homeostasis, TRAIL-activated apoptotic signaling pathway, apoptotic process, apoptotic signaling pathway, behavioral response to cocaine, cardiac muscle tissue development, cellular response to mechanical stimulus, death-inducing signaling complex assembly, defense response to other organism, defense response to virus, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway in absence of ligand, extrinsic apoptotic signaling pathway via death domain receptors, immune system process, innate immune response, kidney development, lymph node development, motor neuron apoptotic process, necroptotic signaling pathway, negative regulation of activation-induced cell death of T cells, negative regulation of necroptotic process, positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation, positive regulation of T cell mediated cytotoxicity, positive regulation of activated T cell proliferation, positive regulation of adaptive immune response, positive regulation of apoptotic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cytokine production, positive regulation of execution phase of apoptosis, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of immune response, positive regulation of innate immune response, positive regulation of interleukin-8 production, positive regulation of macrophage differentiation, positive regulation of proteolysis, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type I interferon-mediated signaling pathway, positive regulation of type II interferon production, regulation of apoptotic process, regulation of necroptotic process, response to cocaine, signal transduction, spleen development, thymus development; MF: caspase binding, death effector domain binding, death receptor binding, identical protein binding, protease binding, protein binding, protein-containing complex binding, protein-macromolecule adaptor activity, receptor serine/threonine kinase binding, signaling adaptor activity, tumor necrosis factor receptor binding, tumor necrosis factor receptor superfamily binding; CC: CD95 death-inducing signaling complex, cell body, cytoplasm, cytosol, death-inducing signaling complex, plasma membrane, protein-containing complex, ripoptosome
Pathways: Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Apoptosis, Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), CASP8 activity is inhibited, Caspase activation via Death Receptors in the presence of ligand, Caspase activation via extrinsic apoptotic signalling pathway, Chagas disease - Mus musculus (mouse), Death Receptor Signaling, Dimerization of procaspase-8, Epstein-Barr virus infection - Mus musculus (mouse), FasL/ CD95L signaling, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), MyD88-independent TLR4 cascade , NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Programmed Cell Death, RIG-I-like receptor signaling pathway - Mus musculus (mouse), RIPK1-mediated regulated necrosis, Regulated Necrosis, Regulation by c-FLIP, Regulation of TNFR1 signaling, Regulation of necroptotic cell death, Salmonella infection - Mus musculus (mouse), Signal Transduction, TNF signaling, TNF signaling pathway - Mus musculus (mouse), TNFR1-induced proapoptotic signaling, TRAIL signaling, TRIF (TICAM1)-mediated TLR4 signaling , TRIF-mediated programmed cell death, Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q61160
Entrez ID: 14082
|
Does Knockout of Pcdhb16 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Pcdhb16
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pcdhb16 (protocadherin beta 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, chemical synaptic transmission, homophilic cell adhesion via plasma membrane adhesion molecules, synapse assembly; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, photoreceptor connecting cilium, photoreceptor disc membrane, plasma membrane, postsynaptic membrane, synapse
Pathways:
UniProt: Q8CB45, Q91Y03
Entrez ID: 93887
|
Does Knockout of Npr2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Npr2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Npr2 (natriuretic peptide receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, activation of meiosis involved in egg activation, axonogenesis, axonogenesis involved in innervation, blood circulation, blood vessel development, blood vessel remodeling, bone development, bone growth, c-di-GMP signaling, cGMP biosynthetic process, cGMP metabolic process, cGMP-mediated signaling, cartilage development, cellular response to cGMP, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to peptide, chemical synaptic transmission, chondrocyte differentiation, chondrocyte proliferation, chromosome organization, collateral sprouting, cumulus cell differentiation, cyclic nucleotide biosynthetic process, digestive tract development, digestive tract morphogenesis, endochondral ossification, epidermal growth factor receptor signaling pathway, execution phase of apoptosis, female genitalia development, gastric emptying, genitalia morphogenesis, germ cell development, growth plate cartilage development, intracellular signal transduction, limb development, limb morphogenesis, lymph vessel development, meiotic cell cycle process involved in oocyte maturation, multicellular organism growth, negative regulation of meiotic cell cycle, negative regulation of oocyte maturation, nerve development, neuron apoptotic process, neuronal action potential, oocyte development, ossification, ovarian follicle development, positive regulation of cGMP-mediated signaling, positive regulation of platelet-derived growth factor receptor signaling pathway, post-anal tail morphogenesis, receptor guanylyl cyclase signaling pathway, response to fibroblast growth factor, response to hormone, response to luteinizing hormone, response to salt, response to wounding, sensory perception of sound, signal transduction, single fertilization, smooth muscle tissue development, spermatogenesis, startle response, vacuole organization, vascular wound healing, vasculogenesis, vestibulocochlear nerve development, vestibulocochlear nerve maturation, white fat cell differentiation, wound healing; MF: ATP binding, GTP binding, guanylate cyclase activity, hormone binding, identical protein binding, lyase activity, natriuretic peptide receptor activity, nucleotide binding, peptide hormone binding, phosphorus-oxygen lyase activity, protein kinase activity; CC: cilium, cytoplasm, membrane, neuron projection, nucleus, plasma membrane, synapse
Pathways: Cardiac conduction, Muscle contraction, Oxytocin signaling pathway - Mus musculus (mouse), Physiological factors, Purine metabolism - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), cyclic GMP biosynthesis
UniProt: Q6VVW5
Entrez ID: 230103
|
Does Knockout of Blcap in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Blcap
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Blcap (bladder cancer associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic nuclear changes, apoptotic process, biological_process; CC: cytoplasm, membrane, nucleus
Pathways:
UniProt: P62951
Entrez ID: 53619
|
Does Knockout of Actb in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Actb
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Actb (actin, beta)
Type: protein-coding
Summary: This gene encodes a member of the actin family of proteins. Actins are highly conserved proteins that are among the most abundant proteins in eukaryotic cells and are involved in cell motility, structure, and integrity. Localization, stability, and translation of the transcribed mRNA are regulated through the binding of multiple factors to its 3' UTR sequence. Homozygous knockout mice for this gene exhibit embryonic lethality. Numerous pseudogenes of this gene have been identified in the mouse genome. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: adherens junction assembly, apical protein localization, axonogenesis, cell motility, cellular response to cytochalasin B, cellular response to electrical stimulus, chromatin remodeling, cytoskeleton organization, establishment or maintenance of cell polarity, morphogenesis of a polarized epithelium, negative regulation of cell differentiation, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of double-strand break repair via homologous recombination, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, postsynaptic actin cytoskeleton organization, protein localization to adherens junction, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, regulation of mitotic metaphase/anaphase transition, regulation of norepinephrine uptake, regulation of nucleotide-excision repair, regulation of protein localization to plasma membrane, regulation of synaptic vesicle endocytosis, regulation of transcription by RNA polymerase II, regulation of transepithelial transport; MF: ATP binding, ATP hydrolysis activity, Tat protein binding, hydrolase activity, identical protein binding, kinesin binding, nitric-oxide synthase binding, nitric-oxide synthase regulator activity, nucleotide binding, protein binding, protein kinase binding, structural constituent of postsynaptic actin cytoskeleton, transporter regulator activity; CC: GBAF complex, NuA4 histone acetyltransferase complex, RSC-type complex, SWI/SNF complex, Schaffer collateral - CA1 synapse, actin cytoskeleton, actin filament, adherens junction, apical junction complex, axon, bBAF complex, brahma complex, brush border, calyx of Held, cell-cell junction, chromatin, cortical cytoskeleton, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoskeleton, cytosol, dense body, focal adhesion, glutamatergic synapse, kinetochore, lamellipodium, membrane, membrane raft, myelin sheath, nBAF complex, npBAF complex, nuclear matrix, nucleoplasm, nucleosome, nucleus, plasma membrane, podosome, postsynaptic actin cytoskeleton, protein-containing complex, ribonucleoprotein complex, stress fiber, synapse, tight junction
Pathways: ATP-dependent chromatin remodelers, Adherens junction - Mus musculus (mouse), Adherens junctions interactions, Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Axon guidance, B-WICH complex positively regulates rRNA expression, Bacterial invasion of epithelial cells - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cell-extracellular matrix interactions, Chromatin organization, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Developmental Biology, Dilated cardiomyopathy - Mus musculus (mouse), EPH-Ephrin signaling, EPHB-mediated forward signaling, Epigenetic regulation of gene expression, Extracellular matrix organization, Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Formation of annular gap junctions, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the dystrophin-glycoprotein complex (DGC), Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Gastric acid secretion - Mus musculus (mouse), Gene expression (Transcription), Global Genome Nucleotide Excision Repair (GG-NER), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Interaction between L1 and Ankyrins, L1CAM interactions, Leukocyte transendothelial migration - Mus musculus (mouse), MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Membrane Trafficking, Metabolism of proteins, Nervous system development, Neutrophil extracellular trap formation - Mus musculus (mouse), Non-integrin membrane-ECM interactions, Nucleotide Excision Repair, Oxytocin signaling pathway - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Positive epigenetic regulation of rRNA expression, Post-translational protein modification, Proteoglycans in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases Activate WASPs and WAVEs, RHO GTPases activate IQGAPs, RHOF GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Recycling pathway of L1, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, SWI/SNF chromatin remodelers, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Thermogenesis - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), UCH proteinases, VEGFA-VEGFR2 Pathway, Vesicle-mediated transport, Viral myocarditis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: P60710
Entrez ID: 11461
|
Does Knockout of Ppp1cb in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Ppp1cb
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Ppp1cb (protein phosphatase 1 catalytic subunit beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, circadian regulation of gene expression, entrainment of circadian clock by photoperiod, glycogen metabolic process, protein dephosphorylation, regulation of cell adhesion, regulation of circadian rhythm, regulation of glycogen biosynthetic process, regulation of glycogen catabolic process, rhythmic process; MF: hydrolase activity, metal ion binding, myosin phosphatase activity, myosin-light-chain-phosphatase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein kinase binding, protein serine/threonine phosphatase activity; CC: PTW/PP1 phosphatase complex, chromosome, telomeric region, cytoplasm, cytosol, glycogen granule, nucleolus, nucleoplasm, nucleus, protein phosphatase type 1 complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular senescence - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), G2/M Transition, Herpes simplex virus 1 infection - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Mitotic G2-G2/M phases, Oocyte meiosis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAF activation, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPases activate PAKs, RHO GTPases activate PKNs, Regulation of PLK1 Activity at G2/M Transition, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vascular smooth muscle contraction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: P62141
Entrez ID: 19046
|
Does Knockout of Enkur in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Enkur
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Enkur (enkurin, TRPC channel interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of left/right asymmetry, flagellated sperm motility; MF: SH3 domain binding, calmodulin binding, protein binding; CC: 9+0 motile cilium, 9+2 motile cilium, acrosomal vesicle, axonemal B tubule inner sheath, axonemal microtubule, cell projection, cilium, cytoplasm, cytoskeleton, microtubule cytoskeleton, motile cilium, sperm flagellum, sperm principal piece
Pathways:
UniProt: Q6SP97
Entrez ID: 71233
|
Does Knockout of Mphosph6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mphosph6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mphosph6 (M phase phosphoprotein 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of 5.8S rRNA, rRNA processing; MF: RNA binding, molecular_function; CC: cytoplasm, cytosol, exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D1Q1
Entrez ID: 68533
|
Does Knockout of Hars2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Hars2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Hars2 (histidyl-tRNA synthetase 2)
Type: protein-coding
Summary: This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of histidine to tRNA molecules. Mutations in a similar gene in human have been associated with Perrault syndrome 2 (PRLTS2). [provided by RefSeq, Mar 2015].
Gene Ontology: BP: histidyl-tRNA aminoacylation, mitochondrial translation, translation; MF: ATP binding, RNA binding, aminoacyl-tRNA ligase activity, histidine-tRNA ligase activity, ligase activity, nucleotide binding; CC: cytoplasm, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q99KK9
Entrez ID: 70791
|
Does Knockout of Sestd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Sestd1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sestd1 (SEC14 and spectrin domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; MF: phosphatidic acid binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding; CC: calcium channel complex, intermediate filament cytoskeleton
Pathways:
UniProt: Q80UK0
Entrez ID: 228071
|
Does Knockout of Gm13271 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Gm13271
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Gm13271 (predicted gene 13271)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: B1AYH9
Entrez ID: 435791
|
Does Knockout of Il4ra in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Il4ra
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Il4ra (interleukin 4 receptor, alpha)
Type: protein-coding
Summary: Predicted to enable interleukin-4 receptor activity. Involved in positive regulation of chemokine production; positive regulation of cold-induced thermogenesis; and positive regulation of macrophage activation. Acts upstream of or within several processes, including defense response to protozoan; negative regulation of T-helper 1 cell differentiation; and positive regulation of immune effector process. Predicted to be located in centriolar satellite; extracellular space; and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal medulla; early conceptus; hemolymphoid system; medulla oblongata basal plate mantle layer; and reproductive system. Used to study asthma. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; multiple sclerosis (multiple); renal tuberculosis; and rheumatoid arthritis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: defense response to protozoan, immune system process, immunoglobulin mediated immune response, interleukin-4-mediated signaling pathway, negative regulation of T-helper 1 cell differentiation, positive regulation of T-helper 2 cell differentiation, positive regulation of chemokine production, positive regulation of cold-induced thermogenesis, positive regulation of immunoglobulin production, positive regulation of macrophage activation, positive regulation of mast cell degranulation, positive regulation of myoblast fusion, production of molecular mediator involved in inflammatory response, regulation of cell population proliferation; MF: cytokine receptor activity, interleukin-4 receptor activity, protein binding; CC: centriolar satellite, external side of plasma membrane, extracellular region, extracellular space, membrane, nucleoplasm, plasma membrane, receptor complex
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-4 and Interleukin-13 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signaling by Interleukins, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse)
UniProt: P16382
Entrez ID: 16190
|
Does Knockout of Rfx8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Rfx8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rfx8 (regulatory factor X 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding
Pathways:
UniProt: D3YU81
Entrez ID: 619289
|
Does Knockout of Myl12a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Myl12a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Myl12a (myosin, light chain 12A, regulatory, non-sarcomeric)
Type: protein-coding
Summary: Enables glutamate receptor binding activity. Acts upstream of or within protein localization to plasma membrane and regulation of cell shape. Located in Z disc and stress fiber. Part of myosin II complex. Orthologous to human MYL12A (myosin light chain 12A). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology:
Pathways: Axon guidance - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: D3YV37, Q6ZWQ9, D3Z249
Entrez ID: 67268
|
Does Knockout of Camk1g in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Camk1g
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Camk1g (calcium/calmodulin-dependent protein kinase I gamma)
Type: protein-coding
Summary: Enables calcium/calmodulin-dependent protein kinase activity. Predicted to be involved in signal transduction. Located in endomembrane system and plasma membrane. Part of calcium- and calmodulin-dependent protein kinase complex. Is expressed in several structures, including genitourinary system; heart; nervous system; and retina. Orthologous to human CAMK1G (calcium/calmodulin dependent protein kinase IG). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: MF: ATP binding, calcium/calmodulin-dependent protein kinase activity, calmodulin binding, catalytic activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, calcium- and calmodulin-dependent protein kinase complex, cytoplasm, endomembrane system, membrane, plasma membrane
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Glioma - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse)
UniProt: Q91VB2
Entrez ID: 215303
|
Does Knockout of Kif20a in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Kif20a
|
phagocytosis
|
macrophage
|
Gene: Kif20a (kinesin family member 20A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule bundle formation, microtubule-based movement, midbody abscission, mitotic cytokinesis, protein transport, regulation of cytokinesis; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, nucleotide binding, protein kinase binding; CC: Golgi apparatus, cleavage furrow, cytoplasm, cytoskeleton, intercellular bridge, kinesin complex, microtubule, midbody, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: Adaptive Immune System, COPI-dependent Golgi-to-ER retrograde traffic, Cell Cycle, Cell Cycle, Mitotic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, M Phase, MHC class II antigen presentation, Membrane Trafficking, Mitotic Telophase/Cytokinesis, Vesicle-mediated transport
UniProt: P97329
Entrez ID: 19348
|
Does Knockout of Tiprl in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Tiprl
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tiprl (TIP41, TOR signalling pathway regulator-like (S. cerevisiae))
Type: protein-coding
Summary: Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage checkpoint signaling and TOR signaling. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human TIPRL (TOR signaling pathway regulator). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA damage checkpoint signaling, TOR signaling; MF: molecular_function, protein phosphatase activator activity, protein phosphatase inhibitor activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q8BH58
Entrez ID: 226591
|
Does Knockout of Slc38a11 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Slc38a11
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc38a11 (solute carrier family 38, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alpha-amino acid transmembrane transport, amino acid transmembrane transport, amino acid transport, monoatomic ion transport, sodium ion transport; CC: membrane
Pathways:
UniProt: Q3USY0
Entrez ID: 320106
|
Does Knockout of Eme1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Eme1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eme1 (essential meiotic structure-specific endonuclease 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, double-strand break repair, mitotic intra-S DNA damage checkpoint signaling, replication fork processing, resolution of meiotic recombination intermediates, resolution of mitotic recombination intermediates, response to intra-S DNA damage checkpoint signaling; MF: DNA binding, crossover junction DNA endonuclease activity, metal ion binding, nuclease activity, protein binding; CC: Holliday junction resolvase complex, chromatin, endodeoxyribonuclease complex, heterochromatin, nuclear chromosome, nuclear replication fork, nucleolus, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q8BJW7
Entrez ID: 268465
|
Does Knockout of Supt6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Supt6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Supt6 (SPT6, histone chaperone and transcription elongation factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, blastocyst formation, mRNA processing, mRNA transport, nucleobase-containing compound metabolic process, nucleosome organization, positive regulation of transcription elongation by RNA polymerase II, regulation of isotype switching, regulation of muscle cell differentiation, transcription elongation by RNA polymerase II, transcription elongation-coupled chromatin remodeling; MF: DNA binding, histone binding, nucleic acid binding, nucleosome binding, protein binding; CC: nucleus, transcription elongation factor complex
Pathways: Formation of RNA Pol II elongation complex , Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q62383
Entrez ID: 20926
|
Does Knockout of Kl in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Kl
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Kl (klotho)
Type: protein-coding
Summary: Enables fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including determination of adult lifespan; energy reserve metabolic process; and positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway. Predicted to be located in extracellular region and membrane. Is expressed in brain; cerebral cortex; femur; hippocampus; and metanephros. Used to study hyperphosphatemic familial tumoral calcinosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: calcium ion homeostasis, carbohydrate metabolic process, determination of adult lifespan, energy reserve metabolic process, fibroblast growth factor receptor signaling pathway, negative regulation of systemic arterial blood pressure, norepinephrine biosynthetic process, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation of bone mineralization, response to activity, response to angiotensin, response to fibroblast growth factor, response to vitamin D; MF: beta-glucuronidase activity, fibroblast growth factor binding, fibroblast growth factor receptor binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, protein binding; CC: apical plasma membrane, extracellular region, membrane, plasma membrane
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), Downstream signaling of activated FGFR1, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), FGFR1 ligand binding and activation, FGFR1c and Klotho ligand binding and activation, FRS-mediated FGFR1 signaling, IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, Longevity regulating pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of FGFR1 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR1, PI3K Cascade, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pentose and glucuronate interconversions - Mus musculus (mouse), Phospholipase C-mediated cascade: FGFR1, RAF/MAP kinase cascade, SHC-mediated cascade:FGFR1, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: O35082
Entrez ID: 16591
|
Does Knockout of Brcc3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Brcc3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Brcc3 (BRCA1/BRCA2-containing complex, subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, NLRP3 inflammasome complex assembly, cell division, cellular response to ionizing radiation, chromatin organization, chromatin remodeling, double-strand break repair, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, positive regulation of DNA repair, positive regulation of NLRP3 inflammasome complex assembly, protein K63-linked deubiquitination, proteolysis, regulation of DNA damage checkpoint, regulation of DNA repair, response to X-ray, response to ionizing radiation; MF: K63-linked deubiquitinase activity, cysteine-type deubiquitinase activity, enzyme regulator activity, hydrolase activity, metal ion binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, polyubiquitin modification-dependent protein binding, protein binding; CC: BRCA1-A complex, BRISC complex, cytoplasm, cytoskeleton, nuclear ubiquitin ligase complex, nucleoplasm, nucleus, spindle pole, ubiquitin ligase complex
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, G2/M DNA damage checkpoint, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, NOD-like receptor signaling pathway - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Processing of DNA double-strand break ends, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: P46737
Entrez ID: 210766
|
Does Knockout of Pcdhb3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Pcdhb3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pcdhb3 (protocadherin beta 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q91XZ7
Entrez ID: 93874
|
Does Knockout of Xylb in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Xylb
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Xylb (xylulokinase homolog (H. influenzae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucuronate catabolic process to D-xylulose 5-phosphate, D-xylose metabolic process, carbohydrate metabolic process, carbohydrate phosphorylation, xylulose metabolic process; MF: ATP binding, D-xylulokinase activity, kinase activity, nucleotide binding, transferase activity
Pathways: Formation of xylulose-5-phosphate, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose and glucuronate interconversions - Mus musculus (mouse), xylitol degradation
UniProt: Q3TNA1
Entrez ID: 102448
|
Does Knockout of Cdk5rap1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Cdk5rap1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cdk5rap1 (CDK5 regulatory subunit associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, mitochondrial tRNA modification, negative regulation of cyclin-dependent protein serine/threonine kinase activity, positive regulation of mitochondrial translation, positive regulation of translational fidelity, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of protein metabolic process, tRNA methylthiolation, tRNA modification, tRNA processing; MF: 4 iron, 4 sulfur cluster binding, catalytic activity, iron-sulfur cluster binding, metal ion binding, methylthiotransferase activity, protein-containing complex binding, tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity, transferase activity; CC: cytosol, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways:
UniProt: Q8BTW8
Entrez ID: 66971
|
Does Knockout of Etv5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Etv5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Etv5 (ets variant 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cellular response to oxidative stress, locomotory behavior, male germ-line stem cell asymmetric division, negative regulation of transcription by RNA polymerase II, neuromuscular synaptic transmission, positive regulation of DNA-templated transcription, positive regulation of glial cell proliferation, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of branching involved in mammary gland duct morphogenesis, regulation of synapse organization, regulation of transcription by RNA polymerase II, skeletal muscle acetylcholine-gated channel clustering; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: nucleoplasm, nucleus, plasma membrane, synapse
Pathways: Prostate cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q9CXC9
Entrez ID: 104156
|
Does Knockout of Cilp in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Cilp
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cilp (cartilage intermediate layer protein, nucleotide pyrophosphohydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of SMAD protein signal transduction, negative regulation of gene expression, negative regulation of insulin-like growth factor receptor signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: Q66K08
Entrez ID: 214425
|
Does Knockout of Bloc1s4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Bloc1s4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Bloc1s4 (biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino)
Type: protein-coding
Summary: Involved in anterograde synaptic vesicle transport. Acts upstream of or within melanosome organization; neuromuscular process controlling balance; and platelet aggregation. Located in cytoplasm. Part of BLOC-1 complex. Used to study Hermansky-Pudlak syndrome. Orthologous to human BLOC1S4 (biogenesis of lysosomal organelles complex 1 subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anterograde axonal transport, anterograde synaptic vesicle transport, melanosome organization, neuromuscular process controlling balance, neuron projection development, platelet aggregation; CC: BLOC-1 complex, axon cytoplasm, cytoplasm
Pathways: Golgi Associated Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q8VED2
Entrez ID: 117197
|
Does Knockout of Nyap1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Nyap1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nyap1 (neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuron projection morphogenesis, phosphatidylinositol 3-kinase/protein kinase B signal transduction
Pathways:
UniProt: Q6PFX7
Entrez ID: 243300
|
Does Knockout of A130010J15Rik in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
A130010J15Rik
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: A130010J15Rik (RIKEN cDNA A130010J15 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DAE8
Entrez ID: 319266
|
Does Knockout of Rbks in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Rbks
|
cell cycle progression
|
breast epithelium
|
Gene: Rbks (ribokinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-ribose catabolic process, D-ribose metabolic process, carbohydrate phosphorylation, pentose-phosphate shunt; MF: ATP binding, identical protein binding, kinase activity, metal ion binding, nucleotide binding, ribokinase activity, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), ribose degradation
UniProt: Q8R1Q9
Entrez ID: 71336
|
Does Knockout of Orc3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Orc3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Orc3 (origin recognition complex, subunit 3)
Type: protein-coding
Summary: Predicted to enable DNA replication origin binding activity. Acts upstream of or within glial cell proliferation and neural precursor cell proliferation. Predicted to be located in chromatin and nuclear body. Predicted to be part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Orthologous to human ORC3 (origin recognition complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA replication, DNA replication initiation, glial cell proliferation, neural precursor cell proliferation, regulation of DNA replication; MF: DNA binding, DNA replication origin binding; CC: DNA replication preinitiation complex, chromatin, chromosome, nuclear body, nuclear origin of replication recognition complex, nuclear pre-replicative complex, nucleoplasm, nucleus, origin recognition complex
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the ORC complex at the origin of replication, Assembly of the pre-replicative complex, CDC6 association with the ORC:origin complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: Q9JK30
Entrez ID: 50793
|
Does Knockout of Ccnl2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ccnl2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ccnl2 (cyclin L2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of RNA splicing, regulation of apoptotic process, regulation of cell cycle, regulation of centrosome cycle, regulation of transcription by RNA polymerase II; MF: cyclin-dependent protein serine/threonine kinase regulator activity, protein binding; CC: cyclin-dependent protein kinase holoenzyme complex, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q9JJA7
Entrez ID: 56036
|
Does Knockout of Chgb in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Chgb
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Chgb (chromogranin B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space, secretory granule
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: P16014
Entrez ID: 12653
|
Does Knockout of Nfs1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Nfs1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nfs1 (nitrogen fixation gene 1 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Mo-molybdopterin cofactor biosynthetic process, [2Fe-2S] cluster assembly, [4Fe-4S] cluster assembly, iron-sulfur cluster assembly, molybdopterin cofactor biosynthetic process; MF: cysteine desulfurase activity, iron-sulfur cluster binding, metal ion binding, protein homodimerization activity, pyridoxal phosphate binding, sulfur carrier activity, transferase activity; CC: centrosome, cytosol, iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrial matrix, mitochondrion, nucleoplasm, nucleus
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Complex III assembly, Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Mitochondrial iron-sulfur cluster biogenesis, Molybdenum cofactor biosynthesis, Respiratory electron transport, Sulfur relay system - Mus musculus (mouse), Thiamine metabolism - Mus musculus (mouse)
UniProt: Q9Z1J3
Entrez ID: 18041
|
Does Knockout of Rpl17 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Rpl17
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rpl17 (ribosomal protein L17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to amino acid starvation, cytoplasmic translation, positive regulation of G1/S transition of mitotic cell cycle, response to amino acid starvation, translation, translation at postsynapse, translation at presynapse; MF: large ribosomal subunit rRNA binding, protein binding, structural constituent of ribosome; CC: A band, cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CPR4
Entrez ID: 319195
|
Does Knockout of Slc2a8 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Slc2a8
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Slc2a8 (solute carrier family 2, (facilitated glucose transporter), member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose transmembrane transport, dehydroascorbic acid transport, fructose transmembrane transport, galactose transmembrane transport, glucose metabolic process, insulin receptor signaling pathway, male meiosis I, response to hypoxia, transmembrane transport; MF: D-glucose binding, D-glucose transmembrane transporter activity, dehydroascorbic acid transmembrane transporter activity, fructose transmembrane transporter activity, fructose uniporter activity, galactose transmembrane transporter activity, transmembrane transporter activity; CC: cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, plasma membrane, synaptic vesicle
Pathways: Cargo recognition for clathrin-mediated endocytosis, Cellular hexose transport, Clathrin-mediated endocytosis, Membrane Trafficking, SLC-mediated transmembrane transport, Transport of small molecules, Vesicle-mediated transport
UniProt: Q9JIF3
Entrez ID: 56017
|
Does Knockout of 4921536K21Rik in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
4921536K21Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 4921536K21Rik (RIKEN cDNA 4921536K21 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9CR34
Entrez ID: 67430
|
Does Knockout of Eif5a in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Eif5a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Eif5a (eukaryotic translation initiation factor 5A)
Type: protein-coding
Summary: This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: cellular response to virus, negative regulation of apoptotic process, positive regulation of apoptotic process, positive regulation of cardiac muscle cell apoptotic process, positive regulation of cytosolic calcium ion concentration, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of muscle cell differentiation, positive regulation of reactive oxygen species metabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of translational elongation, positive regulation of translational termination, translation, translational elongation, tumor necrosis factor-mediated signaling pathway; MF: RNA binding, U6 snRNA binding, ribosome binding, translation elongation factor activity; CC: annulate lamellae, cytoplasm, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, neuronal cell body, nuclear pore, nucleus, synapse
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification
UniProt: P63242
Entrez ID: 276770
|
Does Knockout of D7Ertd443e in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
D7Ertd443e
|
protein/peptide distribution
|
myoblast cell line
|
Gene: D7Ertd443e (DNA segment, Chr 7, ERATO Doi 443, expressed)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, mitotic G2 DNA damage checkpoint signaling, negative regulation of cell growth, protein polyubiquitination, protein stabilization, protein ubiquitination, regulation of centriole replication, response to UV, response to ionizing radiation; MF: histone deacetylase binding, protein binding, transferase activity, ubiquitin protein ligase activity; CC: actin cytoskeleton, centriole, centrosome, cytoplasm, cytoskeleton, cytosol, nucleoplasm
Pathways:
UniProt: D2J0Y4
Entrez ID: 71007
|
Does Knockout of Pitpna in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Pitpna
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pitpna (phosphatidylinositol transfer protein, alpha)
Type: protein-coding
Summary: This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate by phosphoinositide-3-kinase. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: axonogenesis, intermembrane lipid transfer, lipid transport, phospholipid transport; MF: fatty-acyl-CoA binding, lipid binding, phosphatidylcholine binding, phosphatidylcholine transfer activity, phosphatidylcholine transporter activity, phosphatidylinositol binding, phosphatidylinositol transfer activity, phospholipid binding, phospholipid transporter activity, stearic acid binding; CC: cytoplasm, cytosol, membrane, myelin sheath, nucleus
Pathways:
UniProt: P53810
Entrez ID: 18738
|
Does Knockout of Zmym5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Zmym5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zmym5 (zinc finger, MYM-type 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, zinc ion binding
Pathways:
UniProt: Q3U2E2
Entrez ID: 219105
|
Does Knockout of Zfp595 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Zfp595
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp595 (zinc finger protein 595)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8BIN6, B9EIT6, Q3UWJ2
Entrez ID: 218314
|
Does Knockout of Ngdn in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Ngdn
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ngdn (neuroguidin, EIF4E binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of protein localization to plasma membrane, postsynaptic modulation of chemical synaptic transmission, regulation of translation, regulation of translation at postsynapse, ribosomal small subunit biogenesis; CC: axon, cell projection, chromosome, chromosome, centromeric region, cytoplasm, dendrite, filopodium, glutamatergic synapse, mitochondrion, nucleolus, nucleoplasm, nucleus, perforant pathway to dendrate granule cell synapse, postsynapse, small-subunit processome
Pathways:
UniProt: Q9DB96
Entrez ID: 68966
|
Does Knockout of Aamp in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Aamp
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Aamp (angio-associated migratory protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cell surface, cytoplasm, intercellular bridge, microtubule cytoskeleton, plasma membrane
Pathways: Hemostasis, Immune System, Innate Immune System, NOD1/2 Signaling Pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Platelet activation, signaling and aggregation, Signal Transduction, Signal amplification, Signaling by EGFR, Signaling by Receptor Tyrosine Kinases, Thromboxane signalling through TP receptor
UniProt: J3QN89, Q3TJ22, A0A087WR11, A0A087WNM5
Entrez ID: 227290
|
Does Knockout of Krtap5-1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Krtap5-1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Krtap5-1 (keratin associated protein 5-1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be located in intermediate filament. Orthologous to human KRTAP5-2 (keratin associated protein 5-2) and KRTAP5-5 (keratin associated protein 5-5). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: CC: cellular_component, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: Q64507
Entrez ID: 50774
|
Does Knockout of Krt7 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Krt7
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Krt7 (keratin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermediate filament organization, keratinization; MF: protein binding, structural constituent of skin epidermis; CC: cytoplasm, cytosol, intermediate filament, intermediate filament cytoskeleton, keratin filament
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q9DCV7
Entrez ID: 110310
|
Does Knockout of Prm2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Prm2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prm2 (protamine 2)
Type: protein-coding
Summary: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is synthesized as a precursor and then cleaved to give rise to a family of protamine 2 peptides. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cell differentiation, chromosome condensation, chromosome organization, nucleus organization, spermatid development, spermatogenesis; MF: DNA binding, cadmium ion binding, zinc ion binding; CC: chromosome, male germ cell nucleus, nucleoplasm, nucleosome, nucleus
Pathways:
UniProt: P07978
Entrez ID: 19119
|
Does Knockout of Ilkap in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Ilkap
|
phagocytosis
|
macrophage
|
Gene: Ilkap (integrin-linked kinase-associated serine/threonine phosphatase 2C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of nuclear cell cycle DNA replication, signal transduction; MF: cation binding, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity
Pathways:
UniProt: Q8R0F6
Entrez ID: 67444
|
Does Knockout of Fabp6 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Fabp6
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Fabp6 (fatty acid binding protein 6)
Type: protein-coding
Summary: The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within the ileum, the distal 25-30% of the small intestine, and plays a role in enterohepatic circulation of bile acids and cholesterol homeostasis. In humans, it has been reported that polymorphisms in FABP6 confer a protective effect in obese individuals from developing type 2 diabetes. In mice deficiency of this gene affects bile acid metabolism in a gender-specific manner and was reported to be required for efficient apical to basolateral transport of conjugated bile acids. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: bile acid metabolic process, fatty acid transport, lipid transport; MF: fatty acid binding, lipid binding; CC: cytoplasm, cytosol, membrane, nucleus
Pathways: Bile acid and bile salt metabolism, Metabolism, Metabolism of lipids, Metabolism of steroids, PPAR signaling pathway - Mus musculus (mouse), Recycling of bile acids and salts, Triglyceride catabolism, Triglyceride metabolism
UniProt: P51162
Entrez ID: 16204
|
Does Knockout of Daw1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Daw1
|
cell cycle progression
|
breast epithelium
|
Gene: Daw1 (dynein assembly factor with WDR repeat domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonemal dynein complex assembly, cerebrospinal fluid circulation, determination of left/right symmetry, epithelial cilium movement involved in extracellular fluid movement, establishment of localization in cell, heart development, intraciliary transport, outer dynein arm assembly, protein polyubiquitination; CC: SCF ubiquitin ligase complex, cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, extracellular region, motile cilium
Pathways:
UniProt: D3Z7A5
Entrez ID: 71227
|
Does Knockout of Pam in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Pam
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pam (peptidylglycine alpha-amidating monooxygenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress, fatty acid primary amide biosynthetic process, lipid metabolic process, long-chain fatty acid metabolic process, peptide amidation, peptide metabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of actin cytoskeleton organization, regulation of transcription by RNA polymerase II, response to pH, response to xenobiotic stimulus, response to zinc ion, toxin metabolic process; MF: L-ascorbic acid binding, calcium ion binding, catalytic activity, copper ion binding, identical protein binding, lyase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen, peptidylamidoglycolate lyase activity, peptidylglycine monooxygenase activity, protein kinase binding, zinc ion binding; CC: cell surface, cytoplasmic vesicle, cytosol, extracellular region, extracellular space, membrane, neuronal cell body, perikaryon, perinuclear region of cytoplasm, plasma membrane, secretory granule, secretory granule membrane, trans-Golgi network, transport vesicle membrane
Pathways:
UniProt: P97467
Entrez ID: 18484
|
Does Knockout of Alx3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Alx3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Alx3 (aristaless-like homeobox 3)
Type: protein-coding
Summary: This gene belongs to Group 1 of aristaless-like genes, which are characterized by the presence of an aristaless domain and a conserved paired-like homeodomain. The encoded protein acts as a transcriptional regulator. The protein plays a role in the development of craniofacial and appendicular skeleton and may have a role in pancreatic function. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, embryonic skeletal system morphogenesis, neuron development, pattern specification process, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: O70137
Entrez ID: 11694
|
Does Knockout of Vps39 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Vps39
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Vps39 (VPS39 HOPS complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome-lysosome fusion, autophagy, endocytic recycling, endosomal vesicle fusion, endosome to lysosome transport, intracellular protein transport, late endosome to lysosome transport, protein transport, vesicle-mediated transport; CC: AP-3 adaptor complex, HOPS complex, cytoplasm, endomembrane system, endosome, late endosome, late endosome membrane, lysosomal HOPS complex, lysosomal membrane, lysosome, membrane
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q8R5L3
Entrez ID: 269338
|
Does Knockout of Csf2rb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Csf2rb
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Csf2rb (colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, cytokine-mediated signaling pathway, granulocyte-macrophage colony-stimulating factor signaling pathway, immunoglobulin mediated immune response, interleukin-3-mediated signaling pathway, interleukin-5-mediated signaling pathway, positive regulation of leukocyte proliferation, regulation of cell growth; MF: coreceptor activity, cytokine receptor activity, protein binding; CC: external side of plasma membrane, granulocyte macrophage colony-stimulating factor receptor complex, membrane, plasma membrane
Pathways: Apoptosis - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, JAK-STAT signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Pathways in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Signal Transduction, Signaling by Interleukins
UniProt: P26955
Entrez ID: 12983
|
Does Knockout of Mcts1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Mcts1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mcts1 (malignant T cell amplified sequence 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, IRES-dependent viral translational initiation, formation of translation preinitiation complex, ribosome disassembly, translation, translation reinitiation, translational initiation; MF: RNA binding, RNA cap binding, ribosomal small subunit binding, translation initiation factor activity; CC: cytoplasm
Pathways:
UniProt: Q9DB27
Entrez ID: 68995
|
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