prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Mtpap in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Mtpap
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mtpap (mitochondrial poly(A) polymerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, RNA metabolic process, histone mRNA catabolic process, mRNA processing, mitochondrial RNA 3'-end processing, mitochondrial mRNA polyadenylation; MF: ATP binding, RNA binding, UTP binding, identical protein binding, magnesium ion binding, manganese ion binding, metal ion binding, nucleotide binding, poly(A) RNA polymerase activity, protein homodimerization activity, transferase activity; CC: cytoplasm, mitochondrion, nucleoplasm
Pathways:
UniProt: Q9D0D3
Entrez ID: 67440
|
Does Knockout of Eci2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Eci2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Eci2 (enoyl-Coenzyme A delta isomerase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid beta-oxidation, fatty acid catabolic process; MF: delta(3)-delta(2)-enoyl-CoA isomerase activity, fatty-acyl-CoA binding, intramolecular oxidoreductase activity, transposing C=C bonds, isomerase activity; CC: mitochondrion, peroxisomal matrix, peroxisome
Pathways: Beta-oxidation of very long chain fatty acids, Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Peroxisomal lipid metabolism, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Protein localization, fatty acid β-oxidation I, fatty acid β-oxidation III (unsaturated, odd number), fatty acid β-oxidation IV (unsaturated, even number)
UniProt: Q9WUR2
Entrez ID: 23986
|
Does Knockout of Bcdin3d in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Bcdin3d
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Bcdin3d (BCDIN3 domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, methylation, negative regulation of pre-miRNA processing, pre-miRNA processing, tRNA methylation; MF: O-methyltransferase activity, RNA methyltransferase activity, methyltransferase activity, pre-miRNA binding, small RNA 2'-O-methyltransferase activity, tRNA methyltransferase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, plasma membrane
Pathways:
UniProt: Q91YP1
Entrez ID: 75284
|
Does Knockout of Dysf in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Dysf
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dysf (dysferlin)
Type: protein-coding
Summary: Enables alpha-tubulin binding activity and microtubule binding activity. Involved in vesicle fusion. Acts upstream of or within several processes, including myeloid cell activation involved in immune response; negative regulation of macromolecule metabolic process; and plasma membrane organization. Located in several cellular components, including T-tubule; lamellipodium; and microtubule. Is expressed in future spinal cord and heart ventricle. Used to study autosomal recessive limb-girdle muscular dystrophy type 2B and distal myopathy. Human ortholog(s) of this gene implicated in Miyoshi muscular dystrophy 1; autosomal recessive limb-girdle muscular dystrophy type 2B; distal myopathy with anterior tibial onset; and muscular dystrophy. Orthologous to human DYSF (dysferlin). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: T-tubule organization, angiogenesis, cellular response to osmotic stress, fat cell differentiation, glycerol metabolic process, lipid storage, macrophage activation involved in immune response, membrane fusion, monocyte activation involved in immune response, muscle cell development, negative regulation of gene expression, negative regulation of phagocytosis, negative regulation of protein catabolic process, negative regulation of protein polyubiquitination, plasma membrane repair, positive regulation of cell adhesion, positive regulation of endothelial cell proliferation, positive regulation of neutrophil chemotaxis, regulation of calcium ion import, skeletal muscle tissue regeneration, vesicle fusion; MF: alpha-tubulin binding, calcium ion binding, calcium-dependent phospholipid binding, lipid binding, metal ion binding, microtubule binding, phospholipid binding, protein binding; CC: Golgi apparatus, T-tubule, centriolar satellite, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, early endosome, endocytic vesicle, endomembrane system, endosome, lamellipodium, late endosome, late endosome membrane, membrane, membrane microdomain, microtubule, microtubule cytoskeleton, nucleus, plasma membrane, sarcolemma
Pathways:
UniProt: Q9ESD7
Entrez ID: 26903
|
Does Knockout of Thrb in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Thrb
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Thrb (thyroid hormone receptor beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, cell differentiation, cellular response to thyroid hormone stimulus, female courtship behavior, mRNA transcription by RNA polymerase II, negative regulation of DNA-templated transcription, negative regulation of female receptivity, negative regulation of transcription by RNA polymerase II, positive regulation of cell population proliferation, positive regulation of chondrocyte differentiation, positive regulation of ossification, positive regulation of thyroid hormone receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cholesterol metabolic process, regulation of female receptivity, regulation of heart contraction, regulation of lipid metabolic process, regulation of transcription by RNA polymerase II, regulation of triglyceride metabolic process, retinal cone cell apoptotic process, retinal cone cell development, retinoic acid receptor signaling pathway, sensory perception of sound, thyroid hormone receptor signaling pathway, type I pneumocyte differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, double-stranded DNA binding, enzyme binding, identical protein binding, metal ion binding, nuclear receptor activity, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, thyroid hormone binding, transcription coactivator binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, nuclear body, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nuclear Receptor transcription pathway, Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of intracellular receptors, Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: P37242
Entrez ID: 21834
|
Does Knockout of Fanca in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,530
|
Knockout
|
Fanca
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Fanca (Fanconi anemia, complementation group A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, female gonad development, interstrand cross-link repair, male gonad development, male meiotic nuclear division, regulation of CD40 signaling pathway, regulation of germ cell proliferation, regulation of inflammatory response, regulation of regulatory T cell differentiation; CC: Fanconi anaemia nuclear complex, chromatin, cytoplasm, nucleoplasm, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: Q9JL70
Entrez ID: 14087
|
Does Knockout of Bcs1l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Bcs1l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Bcs1l (BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone)
Type: protein-coding
Summary: The protein encoded by this gene is a chaperone protein that is involved in the assembly of complex III (CIII), one of the five protein complexes of the mitochondrial respiratory chain, and is necessary for the insertion of the Rieske iron-sulfur (RISP) and Qcr10p proteins into the precomplex. Studies from the yeast ortholog of this protein indicate that it is targeted to the inner membrane of the mitochondria, despite the absence of an N-terminal targeting sequence. Positively charged amino acids located C-terminal to the transmembrane domain are thought to act as an internal targeting signal (PMID:8599931). Mutations in the human ortholog of this gene have been associated with GRACILE syndrome, characterized by Growth retardation, Amino aciduria, Cholestasis, Iron overload, Lactic acidosis, and Early death. Mouse models with the corresponding mutation mimic the phenotype of GRACILE syndrome and display decreased complex III activity and decreased electron transport capacity (PMID:21274865). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly, mitochondrial respiratory chain complex I assembly, mitochondrial respiratory chain complex III assembly, mitochondrion organization, protein insertion into mitochondrial inner membrane from matrix, protein transmembrane transport; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, mitochondrial protein-transporting ATPase activity, nucleotide binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CZP5
Entrez ID: 66821
|
Does Knockout of Gsto2 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Gsto2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Gsto2 (glutathione S-transferase omega 2)
Type: protein-coding
Summary: Predicted to enable glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; and identical protein binding activity. Predicted to be involved in several processes, including L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; and glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: L-ascorbic acid metabolic process, cellular oxidant detoxification, cellular response to arsenic-containing substance, glutathione metabolic process, xenobiotic metabolic process; MF: glutathione dehydrogenase (ascorbate) activity, glutathione transferase activity, identical protein binding, methylarsonate reductase activity, oxidoreductase activity, transferase activity; CC: cytoplasm
Pathways: Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phase II - Conjugation of compounds, Vitamin C (ascorbate) metabolism, glutathione-mediated detoxification
UniProt: Q8K2Q2
Entrez ID: 68214
|
Does Knockout of Rexo4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Rexo4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rexo4 (REX4, 3'-5' exonuclease)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA catabolic process, DNA repair, RNA processing, rRNA processing; MF: 3'-5' exonuclease activity, double-stranded DNA binding, endonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, single-stranded DNA binding; CC: nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q6PAQ4
Entrez ID: 227656
|
Does Knockout of Nrxn1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Nrxn1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Nrxn1 (neurexin I)
Type: protein-coding
Summary: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016].
Gene Ontology: BP: adult behavior, cell adhesion, cellular response to calcium ion, chemical synaptic transmission, gephyrin clustering involved in postsynaptic density assembly, learning, modulation of chemical synaptic transmission, negative regulation of gene expression, neuroligin clustering involved in postsynaptic membrane assembly, neuromuscular process controlling balance, neuron projection development, neurotransmitter secretion, positive regulation of ERK1 and ERK2 cascade, positive regulation of cAMP-mediated signaling, positive regulation of excitatory postsynaptic potential, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of gene expression, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of synapse assembly, positive regulation of synapse maturation, positive regulation of synaptic transmission, glutamatergic, postsynaptic density protein 95 clustering, postsynaptic membrane assembly, prepulse inhibition, presynapse assembly, regulation of biological quality, regulation of grooming behavior, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of postsynaptic density assembly, regulation of postsynaptic specialization assembly, regulation of presynapse assembly, regulation of synaptic vesicle cycle, regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission, signal transduction, social behavior, synapse assembly, synaptic membrane adhesion, trans-synaptic signaling, modulating synaptic transmission, vesicle docking involved in exocytosis, vocal learning, vocalization behavior; MF: acetylcholine receptor binding, calcium channel regulator activity, calcium ion binding, cell adhesion molecule binding, metal ion binding, neuroligin family protein binding, protein binding, protein-containing complex binding, signaling receptor binding, transmembrane signaling receptor activity, type 1 fibroblast growth factor receptor binding; CC: GABA-ergic synapse, Schaffer collateral - CA1 synapse, cell projection, cell surface, endocytic vesicle, endoplasmic reticulum, glutamatergic synapse, membrane, neuronal cell body, nuclear membrane, nucleolus, plasma membrane, presynaptic active zone membrane, presynaptic membrane, protein-containing complex, slit diaphragm, synapse, trans-synaptic protein complex, vesicle
Pathways: Cell adhesion molecules - Mus musculus (mouse), Neurexins and neuroligins, Neuronal System, Protein-protein interactions at synapses
UniProt: P0DI97, Q9CS84
Entrez ID: 18189
|
Does Knockout of Cd151 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Cd151
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cd151 (CD151 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell proliferation, cell migration, positive regulation of cell migration, positive regulation of endocytosis, wound healing, spreading of cells; MF: integrin binding, protein binding; CC: basement membrane, cell surface, membrane, plasma membrane
Pathways: Cell junction organization, Cell-Cell communication, Type I hemidesmosome assembly
UniProt: O35566
Entrez ID: 12476
|
Does Knockout of Akap6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Akap6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Akap6 (A kinase anchor protein 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, cellular response to cAMP, cellular response to cytokine stimulus, cellular response to epinephrine stimulus, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of cation transmembrane transport, positive regulation of cell growth, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of potassium ion transmembrane transport, positive regulation of protein kinase A signaling, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of translation, protein-containing complex localization, regulation of cAMP/PKA signal transduction, regulation of cardiac muscle cell contraction, regulation of membrane repolarization, regulation of metal ion transport, regulation of relaxation of cardiac muscle, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; MF: adenylate cyclase binding, enzyme binding, molecular adaptor activity, protein binding, protein kinase A binding, protein kinase A regulatory subunit binding, protein phosphatase 2A binding, protein-membrane adaptor activity, transmembrane transporter binding; CC: T-tubule, calcium channel complex, caveola, cytoplasm, intercalated disc, junctional sarcoplasmic reticulum membrane, membrane, nuclear envelope, nuclear membrane, nucleus, perinuclear region of cytoplasm, protein-containing complex, sarcolemma, sarcoplasmic reticulum
Pathways:
UniProt: Q3UHR2, Q6PGB9, Q3UHI8, E9Q9K8, Q6ZQD9
Entrez ID: 238161
|
Does Knockout of Pmvk in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Pmvk
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pmvk (phosphomevalonate kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, isopentenyl diphosphate biosynthetic process, mevalonate pathway, lipid metabolic process, response to cholesterol, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: ATP binding, kinase activity, nucleotide binding, phosphomevalonate kinase activity, transferase activity; CC: cytoplasm, cytosol, peroxisome
Pathways: Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, Peroxisome - Mus musculus (mouse), Terpenoid backbone biosynthesis - Mus musculus (mouse), mevalonate pathway I, superpathway of cholesterol biosynthesis
UniProt: Q9D1G2
Entrez ID: 68603
|
Does Knockout of Poldip2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Poldip2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Poldip2 (polymerase (DNA-directed), delta interacting protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, error-free translesion synthesis, mitochondrion organization, mitotic spindle assembly, negative regulation of macroautophagy, positive regulation of focal adhesion assembly, positive regulation of mitotic cell cycle, positive regulation of mitotic cytokinesis, positive regulation of vascular associated smooth muscle cell proliferation, vascular associated smooth muscle cell proliferation; MF: DNA binding, protein-macromolecule adaptor activity; CC: cell-cell junction, midbody, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, mitotic spindle, nucleus
Pathways:
UniProt: Q91VA6
Entrez ID: 67811
|
Does Knockout of Sectm1a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Sectm1a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sectm1a (secreted and transmembrane 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune response, interleukin-2-mediated signaling pathway, positive regulation of T cell cytokine production, signal transduction; MF: cytokine activity, receptor ligand activity; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: A2ABP7, A2ABP9, Q3TBH1, A2ABP8
Entrez ID: 209588
|
Does Knockout of Ttll8 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Ttll8
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Ttll8 (tubulin tyrosine ligase-like family, member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axoneme assembly, cilium assembly, flagellated sperm motility, protein polyglycylation, spermatogenesis; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, protein-glycine ligase activity, protein-glycine ligase activity, initiating; CC: axoneme, cell projection, cilium, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, motile cilium, sperm flagellum
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: A4Q9F1
Entrez ID: 239591
|
Does Knockout of Hp1bp3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Hp1bp3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hp1bp3 (heterochromatin protein 1, binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, heterochromatin organization, nucleosome assembly, regulation of DNA-templated transcription, regulation of cell population proliferation, regulation of nucleus size; MF: DNA binding, nucleosome binding, structural constituent of chromatin; CC: chromosome, nuclear speck, nucleosome, nucleus
Pathways:
UniProt: Q3TEA8
Entrez ID: 15441
|
Does Knockout of Gtf2h2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Gtf2h2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gtf2h2 (general transcription factor II H, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, nucleotide-excision repair, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: RNA polymerase II general transcription initiation factor activity, metal ion binding, zinc ion binding; CC: core TFIIH complex portion of holo TFIIH complex, nuclear speck, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Mus musculus (mouse), DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral carcinogenesis - Mus musculus (mouse), mRNA Capping
UniProt: Q9JIB4
Entrez ID: 23894
|
Does Knockout of Purg in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Purg
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Purg (purine-rich element binding protein G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, purine-rich negative regulatory element binding; CC: nucleus, synapse
Pathways:
UniProt: Q8R4E6
Entrez ID: 75029
|
Does Knockout of Mrps24 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Mrps24
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Mrps24 (mitochondrial ribosomal protein S24)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; genitourinary system; heart; and liver. Orthologous to human MRPS24 (mitochondrial ribosomal protein S24). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CQV5
Entrez ID: 64660
|
Does Knockout of Fancb in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Fancb
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fancb (Fanconi anemia, complementation group B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, bone marrow development, cellular response to camptothecin, cellular response to xenobiotic stimulus, gene expression, hematopoietic stem cell differentiation, interstrand cross-link repair, negative regulation of double-strand break repair via homologous recombination, positive regulation of double-strand break repair via homologous recombination, replication-born double-strand break repair via sister chromatid exchange, response to stress, response to xenobiotic stimulus; CC: Fanconi anaemia nuclear complex, chromatin, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: Q5XJY6
Entrez ID: 237211
|
Does Knockout of Pcyox1l in Regulatory T cell causally result in protein/peptide accumulation?
| 1
| 1,482
|
Knockout
|
Pcyox1l
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Pcyox1l (prenylcysteine oxidase 1 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neutrophil-mediated killing of bacterium, prenylated protein catabolic process, prenylcysteine catabolic process; MF: oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor, prenylcysteine oxidase activity
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q8C7K6
Entrez ID: 240334
|
Does Knockout of Ift27 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Ift27
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ift27 (intraflagellar transport 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cilium assembly, cochlea development, inner ear receptor cell stereocilium organization, intracellular protein transport, intraciliary anterograde transport, intraciliary transport, kidney development, protein transport, smoothened signaling pathway, spermatogenesis, vesicle-mediated transport; MF: GTP binding, GTPase activity, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi membrane, cell projection, centrosome, cilium, cytoplasm, intraciliary transport particle B, motile cilium, nucleus, sperm flagellum, sperm midpiece, sperm principal piece
Pathways: Cilium Assembly, Intraflagellar transport, Organelle biogenesis and maintenance
UniProt: Q9D0P8
Entrez ID: 67042
|
Does Knockout of Psmd3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Psmd3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Psmd3 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of protein catabolic process, ubiquitin-dependent protein catabolic process; MF: enzyme regulator activity, protein binding; CC: cytosol, nucleoplasm, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P14685
Entrez ID: 22123
|
Does Knockout of Notch2 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Notch2
|
cell proliferation
|
Regulatory T cell
|
Gene: Notch2 (notch 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, animal organ morphogenesis, apoptotic process, atrial septum morphogenesis, bone remodeling, camera-type eye morphogenesis, cell differentiation, cell fate determination, cellular response to tumor cell, cholangiocyte proliferation, ciliary body morphogenesis, defense response to bacterium, determination of left/right symmetry, developmental growth, embryonic limb morphogenesis, epithelial cell development, epithelial cell differentiation involved in kidney development, glomerular capillary formation, heart looping, hemopoiesis, hepatocyte proliferation, humoral immune response, in utero embryonic development, inflammatory response to antigenic stimulus, intracellular signal transduction, intrahepatic bile duct development, left/right axis specification, liver development, liver morphogenesis, marginal zone B cell differentiation, morphogenesis of an epithelial sheet, multicellular organism growth, myeloid dendritic cell differentiation, negative regulation of gene expression, negative regulation of macromolecule biosynthetic process, negative regulation of transcription by RNA polymerase II, nephron tubule development, placenta blood vessel development, placenta development, podocyte development, positive regulation of BMP signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of Ras protein signal transduction, positive regulation of apoptotic process, positive regulation of cell development, positive regulation of cell population proliferation, positive regulation of keratinocyte proliferation, positive regulation of miRNA transcription, positive regulation of osteoclast differentiation, positive regulation of smooth muscle cell differentiation, positive regulation of transcription by RNA polymerase II, proximal tubule development, pulmonary valve morphogenesis, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of developmental process, regulation of hemopoiesis, regulation of osteoclast development, regulation of transcription by RNA polymerase II, wound healing; MF: NF-kappaB binding, calcium ion binding, enzyme binding, protein binding, signaling receptor activity, transcription coactivator activity; CC: Golgi apparatus, cell surface, cilium, cytoplasm, cytosol, extracellular region, glutamatergic synapse, membrane, nucleoplasm, nucleus, plasma membrane, postsynaptic density membrane, receptor complex
Pathways: Breast cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Notch signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: O35516
Entrez ID: 18129
|
Does Knockout of Ift22 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Ift22
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ift22 (intraflagellar transport 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, intracellular protein transport, intraciliary anterograde transport, intraciliary transport; MF: GTP binding, GTPase activity, nucleotide binding; CC: cell projection, centrosome, cilium, endomembrane system, intraciliary transport particle B
Pathways: Cilium Assembly, Intraflagellar transport, Organelle biogenesis and maintenance
UniProt: Q9DAI2
Entrez ID: 67286
|
Does Knockout of Ptpn6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Ptpn6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ptpn6 (protein tyrosine phosphatase, non-receptor type 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell receptor signaling pathway, CD27 signaling pathway, MAPK cascade, T cell activation, cell differentiation, cytokine-mediated signaling pathway, cytoplasmic pattern recognition receptor signaling pathway, epididymis development, establishment of localization in cell, hematopoietic progenitor cell differentiation, inflammatory response to wounding, intracellular signal transduction, megakaryocyte development, mitotic cell cycle, natural killer cell mediated cytotoxicity, negative regulation of B cell receptor signaling pathway, negative regulation of MAPK cascade, negative regulation of T cell proliferation, negative regulation of T cell receptor signaling pathway, negative regulation of angiogenesis, negative regulation of humoral immune response mediated by circulating immunoglobulin, negative regulation of inflammatory response to wounding, negative regulation of innate immune response, negative regulation of interleukin-6 production, negative regulation of lipopolysaccharide-mediated signaling pathway, negative regulation of mast cell activation involved in immune response, negative regulation of neutrophil activation, negative regulation of tumor necrosis factor production, pattern recognition receptor signaling pathway, platelet aggregation, platelet formation, positive regulation of angiogenesis, positive regulation of cell adhesion mediated by integrin, positive regulation of cell population proliferation, positive regulation of cytokine production involved in inflammatory response, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of B cell differentiation, regulation of ERK1 and ERK2 cascade, regulation of G1/S transition of mitotic cell cycle, regulation of lipopolysaccharide-mediated signaling pathway, regulation of release of sequestered calcium ion into cytosol, regulation of tumor necrosis factor production; MF: SH2 domain binding, SH3 domain binding, cell adhesion molecule binding, cytokine receptor binding, hydrolase activity, natural killer cell lectin-like receptor binding, non-membrane spanning protein tyrosine phosphatase activity, phosphoprotein phosphatase activity, phosphorylation-dependent protein binding, phosphotyrosine residue binding, protein binding, protein kinase binding, protein tyrosine phosphatase activity, transmembrane receptor protein tyrosine phosphatase activity; CC: alpha-beta T cell receptor complex, apical dendrite, cell-cell junction, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, plasma membrane, protein-containing complex
Pathways: Adaptive Immune System, Adherens junction - Mus musculus (mouse), Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, B cell receptor signaling pathway - Mus musculus (mouse), CD22 mediated BCR regulation, Cell surface interactions at the vascular wall, Co-inhibition by BTLA, Co-inhibition by PD-1, Cytokine Signaling in Immune system, GPVI-mediated activation cascade, Hemostasis, Immune System, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interferon gamma signaling, Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Neutrophil degranulation, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PECAM1 interactions, Platelet activation, signaling and aggregation, Platelet homeostasis, Platelet sensitization by LDL, Proteoglycans in cancer - Mus musculus (mouse), Regulation of IFNA/IFNB signaling, Regulation of KIT signaling, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by ALK, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling by the B Cell Receptor (BCR), T cell receptor signaling pathway - Mus musculus (mouse)
UniProt: P29351
Entrez ID: 15170
|
Does Knockout of Ndufs8 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Ndufs8
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ndufs8 (NADH:ubiquinone oxidoreductase core subunit S8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: 4 iron, 4 sulfur cluster binding, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q8K3J1
Entrez ID: 225887
|
Does Knockout of Ccdc82 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Ccdc82
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ccdc82 (coiled-coil domain containing 82)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6PG04
Entrez ID: 66396
|
Does Knockout of Swi5 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,551
|
Knockout
|
Swi5
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Swi5 (SWI5 recombination repair homolog (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to ionizing radiation, double-strand break repair via homologous recombination; CC: Swi5-Sfr1 complex, nucleus
Pathways:
UniProt: Q8K3D3
Entrez ID: 72931
|
Does Knockout of Ppp1r2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Ppp1r2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ppp1r2 (protein phosphatase 1, regulatory inhibitor subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycogen metabolic process, intracellular signal transduction, regulation of signal transduction; MF: molecular function inhibitor activity, protein domain specific binding, protein phosphatase inhibitor activity; CC: dendritic spine, growth cone
Pathways:
UniProt: Q9DCL8
Entrez ID: 66849
|
Does Knockout of Hs3st6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Hs3st6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hs3st6 (heparan sulfate (glucosamine) 3-O-sulfotransferase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst hatching, heparan sulfate proteoglycan biosynthetic process; MF: [heparan sulfate]-glucosamine 3-sulfotransferase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, cellular_component, membrane
Pathways: Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: Q5GFD5
Entrez ID: 328779
|
Does Knockout of Rasgrf1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Rasgrf1
|
response to virus
|
Microglial Cell Line
|
Gene: Rasgrf1 (RAS protein-specific guanine nucleotide-releasing factor 1)
Type: protein-coding
Summary: Enables glutamate receptor binding activity. Involved in activation of GTPase activity; neuron projection development; and regulation of small GTPase mediated signal transduction. Acts upstream of or within regulation of NMDA receptor activity; regulation of neuronal synaptic plasticity; and type B pancreatic cell proliferation. Located in cytosol and growth cone. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: Ras protein signal transduction, intracellular signal transduction, neuron projection development, positive regulation of MAPK cascade, positive regulation of Rac protein signal transduction, positive regulation of Ras protein signal transduction, positive regulation of fibroblast proliferation, postsynaptic modulation of chemical synaptic transmission, regulation of Ras protein signal transduction, regulation of neuronal synaptic plasticity, regulation of synaptic plasticity, response to endoplasmic reticulum stress, small GTPase-mediated signal transduction, type B pancreatic cell proliferation; MF: glutamate receptor binding, guanyl-nucleotide exchange factor activity, protein binding, receptor tyrosine kinase binding, small GTPase binding; CC: apical dendrite, apicolateral plasma membrane, basolateral plasma membrane, cytosol, glutamatergic synapse, growth cone, neuronal cell body, plasma membrane, postsynapse
Pathways: Focal adhesion - Mus musculus (mouse), MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Ras signaling pathway - Mus musculus (mouse), Signal Transduction
UniProt: P27671
Entrez ID: 19417
|
Does Knockout of Zbtb14 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Zbtb14
|
phagocytosis
|
macrophage
|
Gene: Zbtb14 (zinc finger and BTB domain containing 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac septum development, coronary vasculature development, heart valve development, kidney development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: aggresome, cytosol, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q08376
Entrez ID: 22666
|
Does Knockout of Ankrd13d in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Ankrd13d
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ankrd13d (ankyrin repeat domain 13 family, member D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of receptor internalization; MF: ubiquitin-modified protein reader activity; CC: cytoplasm, endosome, late endosome, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q6PD24
Entrez ID: 68423
|
Does Knockout of Carnmt1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Carnmt1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Carnmt1 (carnosine N-methyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carnosine metabolic process, methylation; MF: S-adenosylmethionine-dependent methyltransferase activity, carnosine N-methyltransferase activity, methyltransferase activity, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Histidine catabolism, Histidine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives
UniProt: Q80UY1
Entrez ID: 67383
|
Does Knockout of Gpr37l1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Gpr37l1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Gpr37l1 (G protein-coupled receptor 37-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Bergmann glial cell differentiation, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cellular response to reactive oxygen species, negative regulation of astrocyte differentiation, negative regulation of neuron differentiation, negative regulation of smoothened signaling pathway, negative regulation of systemic arterial blood pressure, positive regulation of MAPK cascade, positive regulation of cerebellar granule cell precursor proliferation, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, peptide binding, prosaposin receptor activity, protein binding; CC: cell projection, ciliary membrane, membrane, plasma membrane, receptor complex
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q99JG2
Entrez ID: 171469
|
Does Knockout of Smpx in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Smpx
|
phagocytosis
|
macrophage
|
Gene: Smpx (small muscle protein, X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: M band, contractile muscle fiber, costamere, cytoplasm, muscle tendon junction, nucleus
Pathways:
UniProt: Q9DC77
Entrez ID: 66106
|
Does Knockout of Pcdhb11 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Pcdhb11
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pcdhb11 (protocadherin beta 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q8C5K2, Q91UZ8
Entrez ID: 93882
|
Does Knockout of Rpl7l1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Rpl7l1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rpl7l1 (ribosomal protein L7-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: RNA binding, structural constituent of ribosome; CC: cytosol, cytosolic large ribosomal subunit, nucleolus, ribonucleoprotein complex, ribosome
Pathways:
UniProt: Q9D8M4
Entrez ID: 66229
|
Does Knockout of Dapk2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Dapk2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Dapk2 (death-associated protein kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anoikis, apoptotic process, intracellular signal transduction, neutrophil migration, positive regulation of apoptotic process, positive regulation of eosinophil chemotaxis, positive regulation of neutrophil chemotaxis, protein phosphorylation, regulation of intrinsic apoptotic signaling pathway; MF: ATP binding, calmodulin binding, identical protein binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, autophagosome lumen, cytoplasm, cytoplasmic vesicle, nucleus
Pathways: Autophagy - animal - Mus musculus (mouse), Bladder cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: Q8VDF3
Entrez ID: 13143
|
Does Knockout of Ninj1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Ninj1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ninj1 (ninjurin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell adhesion, cellular hyperosmotic response, chemotaxis, cytolysis, ferroptosis, heterotypic cell-cell adhesion, hyaloid vascular plexus regression, inflammatory response, killing of cells of another organism, leukocyte chemotaxis involved in inflammatory response, macrophage chemotaxis, muscle cell differentiation, pericyte cell migration, positive regulation of angiogenesis, positive regulation of cell-matrix adhesion, positive regulation of inflammatory response, positive regulation of osteoclast development, positive regulation of toll-like receptor 4 signaling pathway, programmed necrotic cell death, protein homooligomerization, pyroptotic cell death, regulation of angiogenesis, regulation of monocyte chemotaxis, tissue regeneration; MF: cell adhesion mediator activity, cell-cell adhesion mediator activity, lipopolysaccharide binding, membrane destabilizing activity; CC: extracellular region, filopodium membrane, membrane, plasma membrane, synapse, synaptic membrane
Pathways:
UniProt: O70131
Entrez ID: 18081
|
Does Knockout of Slc35e4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Slc35e4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc35e4 (solute carrier family 35, member E4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, membrane
Pathways:
UniProt: Q8K3D6
Entrez ID: 103710
|
Does Knockout of Smarca1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Smarca1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Smarca1 (SNF2 related chromatin remodeling ATPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, chromatin organization, chromatin remodeling, heterochromatin formation, neural tube closure, neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of neural precursor cell proliferation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent DNA/DNA annealing activity, ATP-dependent activity, acting on DNA, ATP-dependent chromatin remodeler activity, DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, hydrolase activity, nucleosome array spacer activity, nucleosome binding, protein binding; CC: ATPase complex, CERF complex, NURF complex, chromatin, nucleoplasm, nucleus
Pathways:
UniProt: Q6PGB8
Entrez ID: 93761
|
Does Knockout of Dclk1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Dclk1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Dclk1 (doublecortin-like kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: axon extension, axonogenesis, brain development, cell differentiation, central nervous system neuron development, central nervous system projection neuron axonogenesis, dendrite morphogenesis, forebrain development, intracellular signal transduction, negative regulation of protein localization to nucleus, nervous system development, neuron migration, protein localization to nucleus, regulation of postsynapse assembly; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: axon, cytoplasm, glutamatergic synapse, growth cone, postsynapse, postsynaptic density
Pathways:
UniProt: Q9JLM8
Entrez ID: 13175
|
Does Knockout of Usp4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Usp4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Usp4 (ubiquitin specific peptidase 4 (proto-oncogene))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, cellular response to nutrient levels, cellular response to starvation, cytoplasmic translation, negative regulation of TORC1 signaling, negative regulation of protein ubiquitination, negative regulation of translational initiation, positive regulation of TORC1 signaling, positive regulation of translational initiation, protein deubiquitination, protein localization to cell surface, proteolysis, regulation of protein stability, spliceosomal tri-snRNP complex assembly; MF: adenosine receptor binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, identical protein binding, metal ion binding, peptidase activity, protein binding; CC: cytoplasm, nucleus
Pathways:
UniProt: P35123
Entrez ID: 22258
|
Does Knockout of Grhpr in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Grhpr
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Grhpr (glyoxylate reductase/hydroxypyruvate reductase)
Type: protein-coding
Summary: This gene encodes a member of the D-isomer specific 2-hydroxyacid dehydrogenase family of proteins. The encoded protein catalyzes three enzymatic reactions: the conversion of hydroxypyruvate to D-glycerate as well as the reverse reaction, and the conversion of glyoxylate to glycolate. Homozygous knockout mice exhibit elevated synthesis of oxalate and glycerate. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: dicarboxylic acid metabolic process, glyoxylate metabolic process; MF: NAD binding, NADP binding, NADPH binding, carboxylic acid binding, glyoxylate reductase (NADPH) activity, hydroxypyruvate reductase (NADH) activity, hydroxypyruvate reductase (NADPH) activity, hydroxypyruvate reductase [NAD(P)H] activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein homodimerization activity; CC: catalytic complex, cytoplasm, cytosol
Pathways: Glycine, serine and threonine metabolism - Mus musculus (mouse), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Glyoxylate metabolism and glycine degradation, Metabolism, Metabolism of amino acids and derivatives, Pyruvate metabolism - Mus musculus (mouse)
UniProt: Q91Z53
Entrez ID: 76238
|
Does Knockout of Atg101 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,287
|
Knockout
|
Atg101
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atg101 (autophagy related 101)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and protein kinase binding activity. Involved in autophagosome assembly; negative regulation of cell population proliferation; and positive regulation of autophagy. Located in phagophore assembly site. Is expressed in adrenal gland. Orthologous to human ATG101 (autophagy related 101). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: autophagosome assembly, autophagy, negative regulation of cell population proliferation, positive regulation of autophagy; MF: identical protein binding, protein kinase binding, protein-containing complex binding; CC: Atg1/ULK1 kinase complex, cytoplasm, phagophore assembly site
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Macroautophagy, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q9D8Z6
Entrez ID: 68118
|
Does Knockout of Slamf9 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Slamf9
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slamf9 (SLAM family member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, defense response to bacterium, immune response, plasmacytoid dendritic cell chemotaxis, plasmacytoid dendritic cell differentiation; CC: cell surface, external side of plasma membrane, membrane
Pathways:
UniProt: Q9D780
Entrez ID: 98365
|
Does Knockout of Tspyl3 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Tspyl3
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Tspyl3 (TSPY-like 3)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and histone binding activity. Predicted to be active in chromatin and nucleus. Orthologous to human TSPY26P (testis specific protein Y-linked 26, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, nucleosome assembly; MF: chromatin binding, histone binding, molecular_function; CC: chromatin, nucleus
Pathways:
UniProt: Q6PE20, Q3UYP3
Entrez ID: 241732
|
Does Knockout of Dusp4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Dusp4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dusp4 (dual specificity phosphatase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dephosphorylation, endoderm formation, negative regulation of ERK1 and ERK2 cascade, negative regulation of MAPK cascade, signal transduction; MF: MAP kinase phosphatase activity, MAP kinase serine/threonine phosphatase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, hydrolase activity, mitogen-activated protein kinase binding, phosphatase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/threonine phosphatase activity; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Cytokine Signaling in Immune system, ERK/MAPK targets, ERKs are inactivated, Immune System, Innate Immune System, Interleukin-17 signaling, MAP kinase activation, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK targets/ Nuclear events mediated by MAP kinases, MAPK1/MAPK3 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Negative regulation of MAPK pathway, Nuclear Events (kinase and transcription factor activation), RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, Signal Transduction, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q8BFV3
Entrez ID: 319520
|
Does Knockout of Cdca8 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Cdca8
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cdca8 (cell division cycle associated 8)
Type: protein-coding
Summary: Predicted to be involved in mitotic metaphase chromosome alignment. Located in chromocenter. Is expressed in several structures, including central nervous system; early embryo; gonad; metanephros; and retina. Orthologous to human CDCA8 (cell division cycle associated 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, chromosome organization, mitotic cell cycle, mitotic cytokinesis, mitotic metaphase chromosome alignment, mitotic sister chromatid segregation, mitotic spindle midzone assembly, mitotic spindle organization, positive regulation of attachment of mitotic spindle microtubules to kinetochore, positive regulation of mitotic cell cycle spindle assembly checkpoint, positive regulation of mitotic cytokinesis, positive regulation of mitotic sister chromatid separation; CC: chromocenter, chromosome, chromosome passenger complex, chromosome, centromeric region, cytoplasm, cytoskeleton, intercellular bridge, microtubule cytoskeleton, midbody, nucleolus, nucleoplasm, nucleus, protein-containing complex, spindle, spindle midzone
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BHX3
Entrez ID: 52276
|
Does Knockout of Nkx2-4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Nkx2-4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nkx2-4 (NK2 homeobox 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q9EQM3
Entrez ID: 228731
|
Does Knockout of Vmn1r51 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Vmn1r51
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vmn1r51 (vomeronasal 1 receptor 51)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8VIC6
Entrez ID: 22296
|
Does Knockout of Stat1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Stat1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Stat1 (signal transducer and activator of transcription 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, blood circulation, cell population proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, cellular response to cytokine stimulus, cellular response to interferon-beta, cellular response to lipopolysaccharide, cellular response to type II interferon, cytokine-mediated signaling pathway, defense response, defense response to virus, interleukin-27-mediated signaling pathway, interleukin-7-mediated signaling pathway, interleukin-9-mediated signaling pathway, lipopolysaccharide-mediated signaling pathway, metanephric mesenchymal cell differentiation, metanephric mesenchymal cell proliferation involved in metanephros development, negative regulation by virus of viral protein levels in host cell, negative regulation of angiogenesis, negative regulation of canonical NF-kappaB signal transduction, negative regulation of developmental process, negative regulation of endothelial cell proliferation, negative regulation of macrophage fusion, negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, negative regulation of metanephric nephron tubule epithelial cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of defense response to virus by host, positive regulation of erythrocyte differentiation, positive regulation of interferon-alpha production, positive regulation of mesenchymal cell proliferation, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell population proliferation, regulation of transcription by RNA polymerase II, renal tubule development, response to bacterium, response to cAMP, response to cytokine, response to exogenous dsRNA, response to interferon-beta, response to lipopolysaccharide, response to peptide hormone, response to type I interferon, response to type II interferon, signal transduction, tumor necrosis factor-mediated signaling pathway, type I interferon-mediated signaling pathway, type II interferon-mediated signaling pathway; MF: CCR5 chemokine receptor binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, enzyme binding, histone acetyltransferase binding, histone binding, identical protein binding, promoter-specific chromatin binding, protein binding, protein homodimerization activity, protein phosphatase 2A binding, sequence-specific DNA binding, transcription coactivator binding, transcription corepressor binding, tumor necrosis factor receptor binding, ubiquitin-like protein ligase binding; CC: ISGF3 complex, RNA polymerase II transcription regulator complex, axon, chromatin, cytoplasm, cytosol, dendrite, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q8C3V4, Q99K94, Q8CFQ1, Q8C8M3, Q8C497, A0A087WSP5, A0A087WRI1, A0A087WSQ5
Entrez ID: 20846
|
Does Knockout of Cog6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Cog6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cog6 (component of oligomeric golgi complex 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, glycosylation, intra-Golgi vesicle-mediated transport, protein transport, retrograde transport, vesicle recycling within Golgi; CC: Golgi apparatus, Golgi membrane, Golgi transport complex, membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q8R3I3
Entrez ID: 67542
|
Does Knockout of Tuba1b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Tuba1b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tuba1b (tubulin, alpha 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-4, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, GTPase activity, double-stranded RNA binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding, structural constituent of cytoskeleton, ubiquitin protein ligase binding; CC: cilium, cytoplasm, cytoplasmic microtubule, cytoskeleton, cytosol, membrane raft, microtubule, microtubule cytoskeleton, myelin sheath
Pathways: Adaptive Immune System, Aggrephagy, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Apoptosis - Mus musculus (mouse), Asparagine N-linked glycosylation, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Cilium Assembly, Cytokine Signaling in Immune system, Developmental Biology, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, G2/M Transition, Gap junction - Mus musculus (mouse), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hedgehog 'off' state, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, L1CAM interactions, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, RHOH GTPase cycle, Recruitment of NuMA to mitotic centrosomes, Recycling pathway of L1, Resolution of Sister Chromatid Cohesion, Salmonella infection - Mus musculus (mouse), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Mus musculus (mouse), Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P05213
Entrez ID: 22143
|
Does Knockout of Col25a1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Col25a1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Col25a1 (collagen, type XXV, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: amyloid-beta binding, extracellular matrix structural constituent conferring tensile strength, heparin binding, identical protein binding; CC: collagen trimer, extracellular matrix, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Extracellular matrix organization, Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q99MQ5
Entrez ID: 77018
|
Does Knockout of Apoe in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Apoe
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Apoe (apolipoprotein E)
Type: protein-coding
Summary: This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: AMPA glutamate receptor clustering, G protein-coupled receptor signaling pathway, NMDA glutamate receptor clustering, acylglycerol homeostasis, amyloid precursor protein metabolic process, artery development, artery morphogenesis, cellular oxidant detoxification, cellular response to amyloid-beta, cellular response to lipoprotein particle stimulus, cholesterol catabolic process, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, chylomicron remnant clearance, circulatory system development, fatty acid homeostasis, gene expression, high-density lipoprotein particle assembly, high-density lipoprotein particle clearance, high-density lipoprotein particle remodeling, host-mediated activation of viral process, intermediate-density lipoprotein particle clearance, intracellular calcium ion homeostasis, lipid homeostasis, lipid metabolic process, lipid transport, lipid transport involved in lipid storage, lipoprotein biosynthetic process, lipoprotein catabolic process, lipoprotein metabolic process, locomotory exploration behavior, long-chain fatty acid transport, long-term memory, low-density lipoprotein particle remodeling, maintenance of location in cell, melanosome organization, negative regulation of MAPK cascade, negative regulation of amyloid fibril formation, negative regulation of amyloid-beta formation, negative regulation of blood coagulation, negative regulation of blood vessel endothelial cell migration, negative regulation of canonical Wnt signaling pathway, negative regulation of cholesterol biosynthetic process, negative regulation of cholesterol efflux, negative regulation of dendritic spine development, negative regulation of dendritic spine maintenance, negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, negative regulation of gene expression, negative regulation of inflammatory response, negative regulation of lipid biosynthetic process, negative regulation of lipid metabolic process, negative regulation of lipid transport across blood-brain barrier, negative regulation of long-term synaptic potentiation, negative regulation of neuron projection development, negative regulation of phospholipid efflux, negative regulation of platelet activation, negative regulation of platelet-derived growth factor receptor signaling pathway, negative regulation of postsynaptic membrane organization, negative regulation of protein metabolic process, negative regulation of protein secretion, negative regulation of smooth muscle cell proliferation, negative regulation of triglyceride metabolic process, neuron projection development, nitric oxide-cGMP-mediated signaling, phospholipid efflux, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of amyloid-beta clearance, positive regulation of amyloid-beta formation, positive regulation of axon extension, positive regulation of cholesterol efflux, positive regulation of cholesterol metabolic process, positive regulation of dendritic spine development, positive regulation of dendritic spine maintenance, positive regulation of endocytosis, positive regulation of lipid biosynthetic process, positive regulation of lipid transport across blood-brain barrier, positive regulation of lipoprotein transport, positive regulation of low-density lipoprotein particle receptor catabolic process, positive regulation of membrane protein ectodomain proteolysis, positive regulation of neurofibrillary tangle assembly, positive regulation of neuron projection development, positive regulation of nitric oxide biosynthetic process, positive regulation of phospholipid efflux, positive regulation of presynaptic membrane organization, protein import, receptor-mediated endocytosis, regulation of Cdc42 protein signal transduction, regulation of amyloid fibril formation, regulation of amyloid precursor protein catabolic process, regulation of amyloid-beta clearance, regulation of apoptotic process, regulation of behavioral fear response, regulation of cellular response to very-low-density lipoprotein particle stimulus, regulation of cholesterol metabolic process, regulation of gene expression, regulation of innate immune response, regulation of plasma lipoprotein particle levels, regulation of proteasomal protein catabolic process, regulation of protein metabolic process, regulation of protein-containing complex assembly, regulation of synapse organization, regulation of triglyceride metabolic process, response to caloric restriction, response to dietary excess, response to oxidative stress, reverse cholesterol transport, triglyceride homeostasis, triglyceride metabolic process, triglyceride-rich lipoprotein particle clearance, vasodilation, very-low-density lipoprotein particle clearance, very-low-density lipoprotein particle remodeling, virion assembly; MF: amyloid-beta binding, antioxidant activity, cholesterol transfer activity, enzyme binding, heparan sulfate proteoglycan binding, heparin binding, hydroxyapatite binding, identical protein binding, lipid binding, lipid transporter activity, lipoprotein particle binding, low-density lipoprotein particle receptor binding, metal chelating activity, phosphatidylcholine-sterol O-acyltransferase activator activity, phospholipid binding, protein binding, protein dimerization activity, protein homodimerization activity, protein-containing complex binding, receptor ligand activity, signaling receptor binding, tau protein binding, very-low-density lipoprotein particle receptor binding; CC: Golgi apparatus, cell surface, chylomicron, chylomicron remnant, cytosol, dendrite, discoidal high-density lipoprotein particle, early endosome, endoplasmic reticulum, endosome, extracellular exosome, extracellular matrix, extracellular region, extracellular space, extracellular vesicle, extrinsic component of external side of plasma membrane, glutamatergic synapse, high-density lipoprotein particle, intermediate-density lipoprotein particle, late endosome, lipoprotein particle, low-density lipoprotein particle, melanosome, microtubule, multivesicular body, multivesicular body, internal vesicle, neuronal cell body, nuclear envelope, synaptic cleft, very-low-density lipoprotein particle
Pathways: Alzheimer disease - Mus musculus (mouse), Binding and Uptake of Ligands by Scavenger Receptors, Cholesterol metabolism - Mus musculus (mouse), Chylomicron assembly, Chylomicron clearance, Chylomicron remodeling, HDL remodeling, Metabolism, Metabolism of fat-soluble vitamins, Metabolism of proteins, Metabolism of vitamins and cofactors, Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Plasma lipoprotein remodeling, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Retinoid metabolism and transport, Scavenging by Class A Receptors, Sensory Perception, Transport of small molecules, Vesicle-mediated transport, Visual phototransduction
UniProt: P08226
Entrez ID: 11816
|
Does Knockout of Gm10662 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Gm10662
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gm10662 (predicted gene 10662)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, intracellular signal transduction, microtubule cytoskeleton organization; MF: ATP binding, kinase activity, molecular_function, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, tau-protein kinase activity, transferase activity; CC: cellular_component, cytoplasm
Pathways:
UniProt: Q3UT86
Entrez ID: 100043665
|
Does Knockout of Ogt in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Ogt
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ogt (O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, apoptotic process, cellular response to glucose stimulus, cellular response to lipopolysaccharide, cellular response to nutrient levels, chromatin organization, circadian regulation of gene expression, cytoplasmic translation, glucosamine metabolic process, hemopoiesis, intracellular distribution of mitochondria, membraneless organelle assembly, mitophagy, negative regulation of cell migration, negative regulation of cellular response to hypoxia, negative regulation of non-canonical inflammasome complex assembly, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein targeting to membrane, negative regulation of protein ubiquitination, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of translation, negative regulation of translational initiation, non-canonical inflammasome complex assembly, positive regulation of DNA-templated transcription, positive regulation of TORC1 signaling, positive regulation of cell size, positive regulation of cold-induced thermogenesis, positive regulation of gene expression, positive regulation of lipid biosynthetic process, positive regulation of protein localization to nucleus, positive regulation of proteolysis, positive regulation of reactive oxygen species biosynthetic process, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription from RNA polymerase II promoter by glucose, positive regulation of translation, positive regulation of translational initiation, protein O-linked glycosylation, protein glycosylation, protein localization to lysosome, protein maturation, protein processing, pyroptotic inflammatory response, regulation of Rac protein signal transduction, regulation of gluconeogenesis, regulation of glycolytic process, regulation of insulin receptor signaling pathway, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, regulation of protein localization to membrane, regulation of synapse assembly, regulation of transcription by RNA polymerase II, response to insulin, rhythmic process; MF: N-acetyltransferase activity, catalytic activity, chromatin DNA binding, glycosyltransferase activity, identical protein binding, lipid binding, peptide binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein O-acetylglucosaminyltransferase activity, protein binding, protein domain specific binding, protein-containing complex binding, transferase activity; CC: GABA-ergic synapse, NSL complex, Sin3-type complex, cell projection, cerebellar granule cell to Purkinje cell synapse, cytoplasm, cytosol, euchromatin, glutamatergic synapse, histone acetyltransferase complex, membrane, mitochondrial membrane, mitochondrion, neuronal cell body, nucleoplasm, nucleus, plasma membrane, postsynaptic cytosol, presynaptic cytosol, protein N-acetylglucosaminyltransferase complex, protein-containing complex, synapse, zymogen granule
Pathways: Insulin resistance - Mus musculus (mouse), Other types of O-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q8CGY8
Entrez ID: 108155
|
Does Knockout of Ywhae in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Ywhae
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ywhae (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, MAPK cascade, cellular response to heat, cerebral cortex development, cytoplasmic pattern recognition receptor signaling pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of protein localization, hippo signaling, hippocampus development, intracellular potassium ion homeostasis, intracellular protein localization, negative regulation of calcium ion export across plasma membrane, negative regulation of toll-like receptor signaling pathway, neuron migration, positive regulation of hippo signaling, positive regulation of protein export from nucleus, positive regulation of toll-like receptor signaling pathway, protein K11-linked ubiquitination, protein localization to endoplasmic reticulum, protein localization to nucleus, protein targeting, regulation of cytosolic calcium ion concentration, regulation of membrane repolarization, regulation of mitotic cell cycle, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of potassium ion transmembrane transport, signal transduction, toll-like receptor 4 signaling pathway; MF: calcium channel inhibitor activity, calcium channel regulator activity, enzyme binding, enzyme inhibitor activity, histone deacetylase binding, identical protein binding, phosphoprotein binding, phosphoserine residue binding, potassium channel regulator activity, protein binding, protein domain specific binding, protein heterodimerization activity, protein phosphatase binding, protein phosphatase inhibitor activity, protein sequestering activity, protein-containing complex binding, scaffold protein binding, signaling adaptor activity, transmembrane transporter binding, ubiquitin protein ligase binding; CC: axon, central region of growth cone, cytoplasm, cytosol, endoplasmic reticulum, glutamatergic synapse, kinesin complex, melanosome, mitochondrion, nucleus, plasma membrane, synapse
Pathways: AURKA Activation by TPX2, Activation of BAD and translocation to mitochondria , Activation of BH3-only proteins, Anchoring of the basal body to the plasma membrane, Apoptosis, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cell death signalling via NRAGE, NRIF and NADE, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Cilium Assembly, Death Receptor Signaling, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, HSF1 activation, Hepatitis C - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Intrinsic Pathway for Apoptosis, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Membrane Trafficking, Mitotic G2-G2/M phases, Mitotic Prometaphase, NADE modulates death signalling, NOD-like receptor signaling pathway - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Organelle biogenesis and maintenance, PI3K-Akt signaling pathway - Mus musculus (mouse), Programmed Cell Death, RAB GEFs exchange GTP for GDP on RABs, RHO GTPase Effectors, RHO GTPases activate PKNs, RNA Polymerase II Transcription, Rab regulation of trafficking, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of HSF1-mediated heat shock response, Regulation of PLK1 Activity at G2/M Transition, Signal Transduction, Signaling by Hippo, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, Vesicle-mediated transport, Viral carcinogenesis - Mus musculus (mouse), p75 NTR receptor-mediated signalling
UniProt: P62259
Entrez ID: 22627
|
Does Knockout of Lsm5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Lsm5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Lsm5 (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA catabolic process, mRNA processing, mRNA splicing, via spliceosome, response to bacterium; MF: RNA binding, protein binding, protein heterodimerization activity; CC: Lsm1-7-Pat1 complex, Lsm2-8 complex, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: P62322
Entrez ID: 66373
|
Does Knockout of Lrrc75a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Lrrc75a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lrrc75a (leucine rich repeat containing 75A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q7TSF4
Entrez ID: 192976
|
Does Knockout of Aox1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Aox1
|
cell cycle progression
|
breast epithelium
|
Gene: Aox1 (aldehyde oxidase 1)
Type: protein-coding
Summary: Enables aldehyde oxidase activity and protein homodimerization activity. Involved in NAD catabolic process and xenobiotic metabolic process. Located in cytosol. Is expressed in retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human AOX1 (aldehyde oxidase 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: NAD+ catabolic process, lipid metabolic process, xenobiotic metabolic process; MF: 2 iron, 2 sulfur cluster binding, FAD binding, NAD binding, aldehyde oxidase activity, flavin adenine dinucleotide binding, identical protein binding, iron ion binding, iron-sulfur cluster binding, metal ion binding, molybdopterin cofactor binding, oxidoreductase activity, protein homodimerization activity; CC: cytoplasm, cytosol, intercellular bridge, microtubule cytoskeleton, nuclear body
Pathways: Drug metabolism - cytochrome P450 - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Tryptophan metabolism - Mus musculus (mouse), Tyrosine metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), Vitamin B6 activation to pyridoxal phosphate, Vitamin B6 metabolism - Mus musculus (mouse), nicotine degradation II, nicotine degradation III
UniProt: O54754
Entrez ID: 11761
|
Does Knockout of Foxf1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Foxf1
|
cell cycle progression
|
breast epithelium
|
Gene: Foxf1 (forkhead box F1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, blood vessel development, cardiac left ventricle morphogenesis, cell-cell adhesion, cellular response to cytokine stimulus, detection of wounding, determination of left/right symmetry, digestive tract development, ductus arteriosus closure, embryonic digestive tract development, embryonic digestive tract morphogenesis, embryonic ectodermal digestive tract morphogenesis, embryonic foregut morphogenesis, endocardial cushion development, epithelial cell differentiation involved in mammary gland alveolus development, epithelial tube branching involved in lung morphogenesis, establishment of epithelial cell apical/basal polarity, extracellular matrix organization, heart development, in utero embryonic development, lateral mesodermal cell differentiation, lung alveolus development, lung development, lung lobe morphogenesis, lung morphogenesis, lung vasculature development, mesenchyme migration, mesoderm development, mesodermal cell differentiation, midgut development, morphogenesis of a branching structure, morphogenesis of an epithelium, negative regulation of DNA-templated transcription, negative regulation of inflammatory response, negative regulation of mast cell degranulation, negative regulation of transcription by RNA polymerase II, pancreas development, positive regulation of DNA-templated transcription, positive regulation of cell migration, positive regulation of cell-substrate adhesion, positive regulation of mesenchymal cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, respiratory tube development, right lung morphogenesis, smooth muscle cell differentiation, smoothened signaling pathway, somitogenesis, system development, trachea development, ureter development, vasculogenesis, venous blood vessel development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q61080
Entrez ID: 15227
|
Does Knockout of Myc in Regulatory T cell causally result in protein/peptide accumulation?
| 1
| 1,570
|
Knockout
|
Myc
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Myc (myelocytomatosis oncogene)
Type: protein-coding
Summary: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].
Gene Ontology: BP: B cell apoptotic process, DNA damage response, DNA-templated transcription, DNA-templated transcription initiation, ERK1 and ERK2 cascade, G1/S transition of mitotic cell cycle, MAPK cascade, NK T cell proliferation, Wnt signaling pathway, amino acid transport, branching involved in ureteric bud morphogenesis, cellular response to UV, cellular response to hypoxia, cellular response to interferon-alpha, cellular response to xenobiotic stimulus, chromatin remodeling, chromosome organization, detection of mechanical stimulus involved in sensory perception of sound, glucose metabolic process, inner mitochondrial membrane organization, intracellular iron ion homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, lactic acid secretion, middle ear morphogenesis, myotube differentiation, negative regulation of D-glucose import, negative regulation of cell division, negative regulation of epithelial cell apoptotic process, negative regulation of fibroblast proliferation, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of monocyte differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription initiation by RNA polymerase II, pigmentation, positive regulation of ATP biosynthetic process, positive regulation of B cell apoptotic process, positive regulation of DNA-templated transcription, positive regulation of acinar cell proliferation, positive regulation of apoptotic signaling pathway, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of cellular respiration, positive regulation of epithelial cell proliferation, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of glial cell proliferation, positive regulation of glycolytic process, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of mesenchymal cell proliferation, positive regulation of metanephric cap mesenchymal cell proliferation, positive regulation of miRNA transcription, positive regulation of mitochondrial membrane potential, positive regulation of oxidative phosphorylation, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein processing, protein-DNA complex disassembly, pyruvate transport, rRNA metabolic process, re-entry into mitotic cell cycle, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle process, regulation of gene expression, regulation of mitotic cell cycle, regulation of oxidative phosphorylation, regulation of somatic stem cell population maintenance, regulation of telomere maintenance, regulation of transcription by RNA polymerase II, response to alkaloid, response to radiation, response to xenobiotic stimulus, skeletal muscle cell differentiation, skeletal system morphogenesis, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SCF ubiquitin ligase complex binding, cis-regulatory region sequence-specific DNA binding, core promoter sequence-specific DNA binding, double-stranded DNA binding, identical protein binding, protein binding, protein dimerization activity, protein-containing complex binding, sequence-specific DNA binding, transcription coregulator binding, transcription regulator activator activity, ubiquitin protein ligase binding; CC: Myc-Max complex, RNA polymerase II transcription repressor complex, axon, chromatin, chromosome, cytoplasm, euchromatin, nuclear body, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex, spindle
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Deubiquitination, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Metabolism of proteins, MicroRNAs in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Proteoglycans in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Salmonella infection - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), TFAP2 (AP-2) family regulates transcription of cell cycle factors, TGF-beta signaling pathway - Mus musculus (mouse), Thyroid cancer - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Ub-specific processing proteases, Wnt signaling pathway - Mus musculus (mouse)
UniProt: P01108
Entrez ID: 17869
|
Does Knockout of Selenof in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Selenof
|
phagocytosis
|
macrophage
|
Gene: Selenof (selenoprotein F)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. Knockout studies in mice also suggest a role for this gene in cataract formation and colon carcinogenesis. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Nov 2016].
Gene Ontology: BP: 'de novo' post-translational protein folding, response to lipopolysaccharide, sperm DNA condensation; MF: oxidoreductase activity, protein binding, selenium binding, thioredoxin peroxidase activity; CC: endoplasmic reticulum, endoplasmic reticulum lumen
Pathways:
UniProt: Q9ERR7
Entrez ID: 93684
|
Does Knockout of Klk15 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Klk15
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Klk15 (kallikrein related-peptidase 15)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be active in extracellular space and secretory granule. Orthologous to human KLK15 (kallikrein related peptidase 15). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: protein maturation, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region, extracellular space, secretory granule
Pathways:
UniProt: A0A0U1RNV4, Q8CGR4
Entrez ID: 317652
|
Does Knockout of Clcc1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,171
|
Knockout
|
Clcc1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Clcc1 (chloride channel CLIC-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, chloride transport, endoplasmic reticulum calcium ion homeostasis, monoatomic ion transmembrane transport, monoatomic ion transport; MF: chloride channel activity, identical protein binding; CC: Golgi apparatus, chloride channel complex, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, nucleus
Pathways:
UniProt: Q99LI2
Entrez ID: 229725
|
Does Knockout of Mybbp1a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Mybbp1a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mybbp1a (MYB binding protein (P160) 1a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to glucose starvation, chromatin remodeling, circadian regulation of gene expression, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of DNA-templated transcription, positive regulation of anoikis, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, regulation of DNA-templated transcription, regulation of G1 to G0 transition, respiratory electron transport chain, rhythmic process, ribosome biogenesis; MF: DNA binding, E-box binding, protein binding, sequence-specific DNA binding, transcription corepressor activity, zinc ion binding; CC: B-WICH complex, NLS-dependent protein nuclear import complex, cytoplasm, nucleolus, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression
UniProt: Q7TPV4
Entrez ID: 18432
|
Does Knockout of Ten1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Ten1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ten1 (TEN1 telomerase capping complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of telomere maintenance via telomerase; MF: DNA binding, single-stranded DNA binding, telomerase inhibitor activity, telomeric DNA binding; CC: CST complex, chromosome, chromosome, telomeric region, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: Q9D7K2
Entrez ID: 69535
|
Does Knockout of Ott in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Ott
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ott (ovary testis transcribed)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q62012
Entrez ID: 18422
|
Does Knockout of Upf3a in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Upf3a
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Upf3a (UPF3 regulator of nonsense transcripts homolog A (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: in utero embryonic development, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of mRNA cis splicing, via spliceosome, positive regulation of translation, random inactivation of X chromosome, spermatogenesis; MF: RNA binding, mRNA binding, nucleic acid binding, protein sequestering activity, telomeric DNA binding; CC: cytoplasm, exon-exon junction complex, neuron projection, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q3ULJ3
Entrez ID: 67031
|
Does Knockout of Stub1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Stub1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Stub1 (STIP1 homology and U-Box containing protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, ERAD pathway, MAPK cascade, cellular response to heat, cellular response to hypoxia, cellular response to misfolded protein, chaperone-mediated autophagy, endoplasmic reticulum unfolded protein response, negative regulation of apoptotic process, negative regulation of cardiac muscle hypertrophy, negative regulation of peroxisome proliferator activated receptor signaling pathway, negative regulation of smooth muscle cell apoptotic process, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of vascular associated smooth muscle contraction, positive regulation of ERAD pathway, positive regulation of chaperone-mediated protein complex assembly, positive regulation of metabolic process, positive regulation of mitophagy, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein ubiquitination, positive regulation of proteolysis, positive regulation of smooth muscle cell apoptotic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked ubiquitination, protein autoubiquitination, protein folding, protein monoubiquitination, protein polyubiquitination, protein quality control for misfolded or incompletely synthesized proteins, protein stabilization, protein ubiquitination, regulation of glucocorticoid metabolic process, regulation of protein stability, response to ischemia, signal transduction, ubiquitin-dependent protein catabolic process; MF: G protein-coupled receptor binding, Hsp70 protein binding, Hsp90 protein binding, R-SMAD binding, SMAD binding, TPR domain binding, enzyme binding, heat shock protein binding, kinase binding, misfolded protein binding, protein binding, protein homodimerization activity, protein-folding chaperone binding, protein-macromolecule adaptor activity, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity; CC: Z disc, cytoplasm, cytosol, endoplasmic reticulum, mitochondrion, nuclear inclusion body, nucleoplasm, nucleus, protein folding chaperone complex, ubiquitin conjugating enzyme complex, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Death Receptor Signaling, Downregulation of ERBB2 signaling, Downregulation of TGF-beta receptor signaling, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, Programmed Cell Death, Protein processing in endoplasmic reticulum - Mus musculus (mouse), RIPK1-mediated regulated necrosis, RNA Polymerase II Transcription, Regulated Necrosis, Regulation of PTEN stability and activity, Regulation of RUNX2 expression and activity, Regulation of TNFR1 signaling, Regulation of necroptotic cell death, Signal Transduction, Signaling by ERBB2, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, TNF signaling, Transcriptional regulation by RUNX2, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9WUD1
Entrez ID: 56424
|
Does Knockout of Brms1l in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Brms1l
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Brms1l (breast cancer metastasis-suppressor 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell migration, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of stem cell population maintenance, regulation of gene expression; CC: Sin3-type complex, nucleoplasm, nucleus
Pathways:
UniProt: Q3U1T3
Entrez ID: 52592
|
Does Knockout of Spidr in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Spidr
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Spidr (scaffolding protein involved in DNA repair)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cellular response to camptothecin, cellular response to hydroxyurea, cellular response to ionizing radiation, double-strand break repair via homologous recombination, positive regulation of double-strand break repair, positive regulation of protein-containing complex assembly, regulation of double-strand break repair via homologous recombination, regulation of establishment of protein localization to chromosome; CC: nuclear chromosome, nucleoplasm, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q8BGX7
Entrez ID: 224008
|
Does Knockout of Tnip3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Tnip3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tnip3 (TNFAIP3 interacting protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MyD88-independent toll-like receptor signaling pathway, cellular response to lipopolysaccharide, negative regulation of canonical NF-kappaB signal transduction, regulation of canonical NF-kappaB signal transduction, regulation of transcription by RNA polymerase II, toll-like receptor 4 signaling pathway
Pathways: Deubiquitination, Metabolism of proteins, Ovarian tumor domain proteases, Post-translational protein modification
UniProt: A0A1D5RMN0, Q3SXA6, A0A1D5RLN9
Entrez ID: 414084
|
Does Knockout of Xbp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Xbp1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Xbp1 (X-box binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, angiogenesis, apoptotic process, autophagy, cell differentiation, cellular response to amino acid stimulus, cellular response to fluid shear stress, cellular response to fructose stimulus, cellular response to glucose starvation, cellular response to glucose stimulus, cellular response to insulin stimulus, cellular response to interleukin-4, cellular response to laminar fluid shear stress, cellular response to leukemia inhibitory factor, cellular response to lipopolysaccharide, cellular response to nutrient, cellular response to oxidative stress, cellular response to peptide hormone stimulus, cellular response to vascular endothelial growth factor stimulus, cholesterol homeostasis, endoplasmic reticulum unfolded protein response, endothelial cell proliferation, epithelial cell maturation involved in salivary gland development, exocrine pancreas development, fatty acid homeostasis, glandular epithelial cell maturation, glucose homeostasis, intracellular triglyceride homeostasis, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, lipid metabolic process, liver development, muscle organ development, negative regulation of ERK1 and ERK2 cascade, negative regulation of SMAD protein signal transduction, negative regulation of apoptotic process, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of endoplasmic reticulum unfolded protein response, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of myotube differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of translation, neuron development, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of B cell differentiation, positive regulation of ERAD pathway, positive regulation of MHC class II biosynthetic process, positive regulation of T cell differentiation, positive regulation of TOR signaling, positive regulation of angiogenesis, positive regulation of autophagy, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of endothelial cell apoptotic process, positive regulation of fat cell differentiation, positive regulation of hepatocyte proliferation, positive regulation of immunoglobulin production, positive regulation of interleukin-6 production, positive regulation of lactation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of plasma cell differentiation, positive regulation of proteasomal protein catabolic process, positive regulation of protein acetylation, positive regulation of protein import into nucleus, positive regulation of protein phosphorylation, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, positive regulation of vascular wound healing, proteasome-mediated ubiquitin-dependent protein catabolic process, protein destabilization, protein transport, regulation of DNA-templated transcription, regulation of autophagy, regulation of cell growth, regulation of protein stability, regulation of transcription by RNA polymerase II, response to electrical stimulus, response to endoplasmic reticulum stress, response to insulin-like growth factor stimulus, response to nutrient, response to unfolded protein, response to xenobiotic stimulus, serotonin secretion, neurotransmission, sterol homeostasis, transcription by RNA polymerase II, ubiquitin-dependent protein catabolic process, vascular endothelial growth factor receptor signaling pathway; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, cis-regulatory region sequence-specific DNA binding, histone deacetylase binding, identical protein binding, phosphatidylinositol 3-kinase regulatory subunit binding, protease binding, protein heterodimerization activity, protein kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, ubiquitin protein ligase binding, ubiquitin-like protein ligase binding; CC: RNA polymerase II transcription regulator complex, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: O35426
Entrez ID: 22433
|
Does Knockout of Ubr2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Ubr2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ubr2 (ubiquitin protein ligase E3 component n-recognin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, cellular response to L-leucine, heterochromatin formation, male meiosis I, male meiotic nuclear division, negative regulation of TOR signaling, positive regulation of T cell receptor signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked ubiquitination, protein catabolic process, protein ubiquitination, reciprocal meiotic recombination, spermatogenesis, transposable element silencing, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the N-end rule pathway; MF: L-leucine binding, histone H2A ubiquitin ligase activity, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: chromatin, chromosome, cytoplasm, nucleus, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q6WKZ8
Entrez ID: 224826
|
Does Knockout of Rpp21 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rpp21
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rpp21 (ribonuclease P 21 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, response to xenobiotic stimulus, tRNA 5'-leader removal, tRNA processing; MF: metal ion binding, ribonuclease P RNA binding, ribonuclease P activity; CC: endoribonuclease complex, multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8R040
Entrez ID: 67676
|
Does Knockout of Fancf in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,537
|
Knockout
|
Fancf
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Fancf (Fanconi anemia, complementation group F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, interstrand cross-link repair, ovarian follicle development, protein ubiquitination, spermatogenesis; CC: Fanconi anaemia nuclear complex, chromatin, nucleoplasm, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: E9Q5Z5
Entrez ID: 100040608
|
Does Knockout of Edaradd in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Edaradd
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Edaradd (EDAR associated via death domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical NF-kappaB signal transduction, cell differentiation, hair follicle development, odontogenesis of dentin-containing tooth, positive regulation of non-canonical NF-kappaB signal transduction, signal transduction, trachea gland development; MF: death receptor binding, protein binding; CC: cytoplasm
Pathways: NF-kappa B signaling pathway - Mus musculus (mouse)
UniProt: Q5D0F1
Entrez ID: 171211
|
Does Knockout of Mall in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Mall
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Mall (mal, T cell differentiation protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi membrane, clathrin-coated vesicle, cytoplasmic vesicle, membrane, membrane raft, plasma membrane
Pathways:
UniProt: Q91X49
Entrez ID: 228576
|
Does Knockout of Vps9d1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Vps9d1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vps9d1 (VPS9 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, vesicle-mediated transport; MF: guanyl-nucleotide exchange factor activity, identical protein binding, molecular_function, small GTPase binding; CC: cytosol, endocytic vesicle
Pathways:
UniProt: Q8C190
Entrez ID: 72325
|
Does Knockout of Rpsa in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Rpsa
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rpsa (ribosomal protein SA)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cytoplasmic translation, ribosomal small subunit assembly, translation; MF: DNA binding, laminin binding, laminin receptor activity, protein binding, ribosome binding, structural constituent of ribosome, structural molecule activity; CC: basement membrane, cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, glutamatergic synapse, membrane, neuronal cell body, nucleus, plasma membrane, postsynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P14206
Entrez ID: 16785
|
Does Knockout of Srgn in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Srgn
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Srgn (serglycin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell secretory granule organization, apoptotic process, biomineral tissue development, granzyme-mediated programmed cell death signaling pathway, maintenance of granzyme B location in T cell secretory granule, maintenance of protease location in mast cell secretory granule, mast cell secretory granule organization, negative regulation of bone mineralization, negative regulation of cytokine production, protein processing, secretory granule organization; MF: collagen binding, protein binding; CC: Golgi apparatus, Golgi membrane, cytolytic granule, extracellular region, extracellular space, lysosome, mast cell granule, secretory granule, zymogen granule
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: P13609
Entrez ID: 19073
|
Does Knockout of Idh3a in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Idh3a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Idh3a (isocitrate dehydrogenase 3 (NAD+) alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: isocitrate metabolic process, tricarboxylic acid cycle; MF: NAD binding, isocitrate dehydrogenase (NAD+) activity, magnesium ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: isocitrate dehydrogenase complex (NAD+), mitochondrial matrix, mitochondrion, myelin sheath
Pathways: Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, TCA cycle variation III (eukaryotic)
UniProt: Q9D6R2
Entrez ID: 67834
|
Does Knockout of Ugt3a2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ugt3a2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ugt3a2 (UDP glycosyltransferases 3 family, polypeptide A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: UDP-glycosyltransferase activity, glucuronosyltransferase activity, glycosyltransferase activity, transferase activity; CC: UDP-N-acetylglucosamine transferase complex, membrane
Pathways: Aspirin ADME, Biological oxidations, Drug ADME, Glucuronidation, Metabolism, Phase II - Conjugation of compounds, nicotine degradation II, nicotine degradation III
UniProt: Q3UP75
Entrez ID: 105887
|
Does Knockout of Gpd1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Gpd1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gpd1 (glycerol-3-phosphate dehydrogenase 1 (soluble))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cellular response to cAMP, cellular response to tumor necrosis factor, gluconeogenesis, glyceraldehyde-3-phosphate biosynthetic process, glycerol-3-phosphate catabolic process, glycerol-3-phosphate metabolic process, glycerol-3-phosphate shuttle, glycerolipid metabolic process, positive regulation of glycolytic process; MF: NAD binding, glycerol-3-phosphate dehydrogenase (NAD+) activity, glycerol-3-phosphate dehydrogenase (quinone) activity, glycerol-3-phosphate dehydrogenase [NAD(P)+] activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein homodimerization activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA, aerobic respiration -- electron donors reaction list, glycerol degradation IV, glycerol-3-phosphate shuttle
UniProt: P13707
Entrez ID: 14555
|
Does Knockout of Rab14 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Rab14
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rab14 (RAB14, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to endosome transport, apical protein localization, body fluid secretion, defense response to bacterium, early endosome to Golgi transport, endocytic recycling, endosomal vesicle fusion, fibroblast growth factor receptor signaling pathway, intracellular protein transport, phagolysosome assembly, phagosome maturation, protein transport, regulation of embryonic development, regulation of protein localization; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, myosin V binding, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi membrane, Golgi stack, alveolar lamellar body, apical plasma membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, early endosome, early endosome membrane, endomembrane system, endosome, late endosome, lysosome, membrane, nuclear outer membrane-endoplasmic reticulum membrane network, perinuclear region of cytoplasm, phagocytic vesicle, plasma membrane, recycling endosome, rough endoplasmic reticulum, synaptic vesicle membrane, trans-Golgi network, trans-Golgi network transport vesicle
Pathways: AMPK signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Membrane Trafficking, Metabolism, Metabolism of lipids, Metabolism of proteins, Neutrophil degranulation, PI Metabolism, Phospholipid metabolism, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Synthesis of PIPs at the plasma membrane, Vesicle-mediated transport
UniProt: Q91V41
Entrez ID: 68365
|
Does Knockout of Aqp9 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Aqp9
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Aqp9 (aquaporin 9)
Type: protein-coding
Summary: This gene encodes a member of the aquaglyceroporin subfamily of aquaporins. This protein transports water, glycerol, urea, purines and pyrimidines and plays a role in glycerol metabolism and osteoclast differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: amine transport, canalicular bile acid transport, cellular response to cAMP, detoxification of arsenic-containing substance, glycerol transmembrane transport, hydrogen peroxide transmembrane transport, polyol transmembrane transport, purine nucleobase transmembrane transport, purine nucleobase transport, pyrimidine nucleobase transport, pyrimidine-containing compound transmembrane transport, response to pain, transmembrane transport, urea transmembrane transport, water transport; MF: channel activity, glycerol channel activity, hydrogen peroxide channel activity, polyol transmembrane transporter activity, purine nucleobase transmembrane transporter activity, pyrimidine nucleobase transmembrane transporter activity, urea channel activity, urea transmembrane transporter activity, water channel activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways: Aquaporin-mediated transport, Bile secretion - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Passive transport by Aquaporins, Transport of glycerol from adipocytes to the liver by Aquaporins, Transport of small molecules
UniProt: Q9JJJ3
Entrez ID: 64008
|
Does Knockout of Btnl6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Btnl6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Btnl6 (butyrophilin-like 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, extrathymic T cell selection, regulation of cytokine production; MF: signaling receptor binding, zinc ion binding; CC: cytoplasm, external side of plasma membrane, membrane
Pathways:
UniProt: A2CG22
Entrez ID: 624681
|
Does Knockout of Ska1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ska1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ska1 (spindle and kinetochore associated complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, cell division, chromosome segregation, establishment of localization in cell, establishment of meiotic spindle orientation, establishment of organelle localization, metaphase chromosome alignment, mitotic cell cycle, mitotic metaphase chromosome alignment, mitotic sister chromatid segregation, negative regulation of mitotic spindle assembly checkpoint signaling, nuclear chromosome segregation, nuclear division, positive regulation of microtubule polymerization, regulation of microtubule polymerization or depolymerization, spindle assembly involved in female meiosis; MF: microtubule binding; CC: SKA complex, centriolar satellite, centrosome, chromosome, chromosome, centromeric region, ciliary basal body, cilium, cytoplasm, cytoskeleton, intercellular bridge, kinetochore, meiotic spindle, microtubule, microtubule cytoskeleton, mitotic spindle, mitotic spindle microtubule, nucleoplasm, outer kinetochore, spindle, spindle microtubule
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CPV1
Entrez ID: 66468
|
Does Knockout of Arhgap12 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Arhgap12
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arhgap12 (Rho GTPase activating protein 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, morphogenesis of an epithelial sheet, negative regulation of small GTPase mediated signal transduction, phagocytosis, engulfment, regulation of postsynapse assembly, signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity, molecular_function; CC: cytoplasm, glutamatergic synapse, phagocytic cup, plasma membrane, postsynapse
Pathways: RAC1 GTPase cycle, RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOV GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8C0D4
Entrez ID: 75415
|
Does Knockout of Otp in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 2,403
|
Knockout
|
Otp
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Otp (orthopedia homeobox)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, dopaminergic neuron differentiation, forebrain neuron differentiation, hypothalamus cell differentiation, negative regulation of transcription by RNA polymerase II, nervous system development, neuroendocrine cell differentiation, neurohypophysis development, neuron differentiation, positive regulation of neuroblast proliferation, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding; CC: fibrillar center, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: O09113
Entrez ID: 18420
|
Does Knockout of Ly6g6f in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Ly6g6f
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ly6g6f (lymphocyte antigen 6 family member G6F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane, plasma membrane
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: B2RXM6
Entrez ID: 433099
|
Does Knockout of Map3k6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Map3k6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Map3k6 (mitogen-activated protein kinase kinase kinase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, MAPK cascade, p38MAPK cascade; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways: MAPK signaling pathway - Mus musculus (mouse)
UniProt: A0A0A0MQ82
Entrez ID: 53608
|
Does Knockout of Ceacam16 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Ceacam16
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ceacam16 (CEA cell adhesion molecule 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: sensory perception of sound; MF: identical protein binding, protein binding; CC: extracellular region, extracellular space, stereocilium tip
Pathways:
UniProt: E9QA28
Entrez ID: 330483
|
Does Knockout of Klrg1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Klrg1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Klrg1 (killer cell lectin-like receptor subfamily G, member 1)
Type: protein-coding
Summary: Predicted to enable carbohydrate binding activity. Predicted to be involved in innate immune response. Predicted to act upstream of or within cell surface receptor signaling pathway. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human KLRG1 (killer cell lectin like receptor G1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell surface receptor signaling pathway, immune system process, innate immune response; MF: carbohydrate binding; CC: membrane, plasma membrane
Pathways:
UniProt: O88713
Entrez ID: 50928
|
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