prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Sectm1a in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Sectm1a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sectm1a (secreted and transmembrane 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune response, interleukin-2-mediated signaling pathway, positive regulation of T cell cytokine production, signal transduction; MF: cytokine activity, receptor ligand activity; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: A2ABP7, A2ABP9, Q3TBH1, A2ABP8
Entrez ID: 209588
|
Does Knockout of Lilra5 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Lilra5
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Lilra5 (leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, cytokine-mediated signaling pathway, immune response-regulating signaling pathway, negative regulation of interleukin-12 production, negative regulation of interleukin-13 production, positive regulation of MAPK cascade, positive regulation of calcium ion transport, positive regulation of cell activation, positive regulation of inflammatory response, positive regulation of interleukin-1 beta production, positive regulation of interleukin-10 production, positive regulation of interleukin-6 production, positive regulation of tumor necrosis factor production; CC: cell surface, extracellular space, membrane, plasma membrane
Pathways: B cell receptor signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation, Osteoclast differentiation - Mus musculus (mouse)
UniProt: D3Z7A9
Entrez ID: 232801
|
Does Knockout of Oc90 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Oc90
|
phagocytosis
|
macrophage
|
Gene: Oc90 (otoconin 90)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate secretion, lipid catabolic process, otolith mineralization, phosphatidylcholine metabolic process, phosphatidylglycerol metabolic process, phospholipid metabolic process; MF: calcium ion binding, calcium-dependent phospholipase A2 activity, metal ion binding, phospholipid binding, protein binding, structural molecule activity; CC: extracellular matrix, extracellular region
Pathways:
UniProt: Q9Z0L3
Entrez ID: 18256
|
Does Knockout of 4930447C04Rik in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
4930447C04Rik
|
response to virus
|
Microglial Cell Line
|
Gene: 4930447C04Rik (RIKEN cDNA 4930447C04 gene)
Type: protein-coding
Summary: Involved in meiosis I; oogenesis; and spermatogenesis. Located in central element. Is expressed in several structures, including genitourinary system; intestine; liver; lung; and retina. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 18 and spermatogenic failure 52. Orthologous to human C14orf39 (chromosome 14 open reading frame 39). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA recombination, cell differentiation, homologous chromosome pairing at meiosis, meiotic DNA double-strand break processing involved in reciprocal meiotic recombination, meiotic cell cycle, oogenesis, regulation of DNA-binding transcription factor activity, spermatogenesis, synaptonemal complex assembly; CC: central element, chromosome
Pathways:
UniProt: Q9CTN5
Entrez ID: 75801
|
Does Knockout of Vwc2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Vwc2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vwc2 (von Willebrand factor C domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of BMP signaling pathway, neurotransmitter receptor localization to postsynaptic specialization membrane, positive regulation of cell-substrate adhesion, positive regulation of neuron differentiation; CC: AMPA glutamate receptor complex, basement membrane, extracellular matrix, extracellular region, extracellular space, extrinsic component of postsynaptic membrane, glutamatergic synapse, interstitial matrix, synapse
Pathways:
UniProt: Q8C8N3
Entrez ID: 319922
|
Does Knockout of Cwc25 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Cwc25
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cwc25 (CWC25 spliceosome-associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; CC: U2-type catalytic step 1 spliceosome, U2-type spliceosomal complex, nuclear speck, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9DBF7
Entrez ID: 67480
|
Does Knockout of Ifnar2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Ifnar2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ifnar2 (interferon (alpha and beta) receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, cellular response to interferon-beta, defense response to virus, immature T cell proliferation in thymus, positive regulation of protein localization to nucleus, regulation of transcription by RNA polymerase II, response to interferon-alpha, response to interferon-beta, type I interferon-mediated signaling pathway; MF: cytokine binding, protein kinase binding, type I interferon binding, type I interferon receptor activity; CC: extracellular region, extracellular space, membrane, plasma membrane, receptor complex
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Regulation of IFNA/IFNB signaling, Toll-like receptor signaling pathway - Mus musculus (mouse)
UniProt: O35664
Entrez ID: 15976
|
Does Knockout of Polr1a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Polr1a
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Polr1a (polymerase (RNA) I polypeptide A)
Type: protein-coding
Summary: Predicted to enable DNA/RNA hybrid binding activity; chromatin binding activity; and metal ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in negative regulation of protein localization to nucleolus and rRNA transcription. Located in chromosome and nucleus. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type and hypomyelinating leukodystrophy. Orthologous to human POLR1A (RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA-templated transcription, negative regulation of protein localization to nucleolus, nucleolar large rRNA transcription by RNA polymerase I, rRNA transcription, transcription by RNA polymerase I; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, DNA/RNA hybrid binding, chromatin binding, magnesium ion binding, metal ion binding, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, chromatin, chromosome, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Mus musculus (mouse)
UniProt: O35134
Entrez ID: 20019
|
Does Knockout of Amd2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Amd2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Amd2 (S-adenosylmethionine decarboxylase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: S-adenosylmethionine metabolic process, polyamine biosynthetic process, polyamine metabolic process, spermidine biosynthetic process, spermine biosynthetic process; MF: adenosylmethionine decarboxylase activity, carboxy-lyase activity, identical protein binding, lyase activity, putrescine binding
Pathways: Arginine and proline metabolism - Mus musculus (mouse), Cysteine and methionine metabolism - Mus musculus (mouse), spermidine biosynthesis I, spermine biosynthesis
UniProt: D3Z6H8
Entrez ID: 100041585
|
Does Knockout of Foxa3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Foxa3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Foxa3 (forkhead box A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, cellular response to starvation, chromatin organization, glucose homeostasis, hematopoietic stem cell homeostasis, intracellular glucose homeostasis, negative regulation of cell population proliferation, positive regulation of hepatocyte differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein domain specific binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: actin cytoskeleton, cytosol, nucleoplasm, nucleus
Pathways: Maturity onset diabetes of the young - Mus musculus (mouse)
UniProt: P35584
Entrez ID: 15377
|
Does Knockout of Pole2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Pole2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pole2 (polymerase (DNA directed), epsilon 2 (p59 subunit))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA metabolic process, DNA replication, DNA-templated DNA replication, error-prone translesion synthesis; CC: chromosome, epsilon DNA polymerase complex, nuclear body, nuclear lumen, nucleoplasm, nucleus
Pathways: Activation of the pre-replicative complex, Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Mus musculus (mouse), DNA replication initiation, Dual Incision in GG-NER, Dual incision in TC-NER, G1/S Transition, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Mitotic G1 phase and G1/S transition, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Recognition of DNA damage by PCNA-containing replication complex, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: O54956
Entrez ID: 18974
|
Does Knockout of Rmnd5a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Rmnd5a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rmnd5a (required for meiotic nuclear division 5 homolog A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: GID complex, cytoplasm, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: Q80YQ8
Entrez ID: 68477
|
Does Knockout of Scamp2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Scamp2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Scamp2 (secretory carrier membrane protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, protein transport; CC: Golgi apparatus, endosome, membrane, recycling endosome membrane, trans-Golgi network membrane
Pathways:
UniProt: Q9ERN0
Entrez ID: 24044
|
Does Knockout of Ndufv2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ndufv2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ndufv2 (NADH:ubiquinone oxidoreductase core subunit V2)
Type: protein-coding
Summary: This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The bovine ortholog of this protein has been characterized and is reported to contain an iron-sulfur cluster, which may be involved in electron transfer. In humans mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: aerobic respiration, cardiac muscle tissue development, mitochondrial electron transport, NADH to ubiquinone, nervous system development, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: 2 iron, 2 sulfur cluster binding, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, myelin sheath, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9D6J6
Entrez ID: 72900
|
Does Knockout of Rasa1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Rasa1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Rasa1 (RAS p21 protein activator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, blood vessel morphogenesis, cellular response to epidermal growth factor stimulus, cellular response to platelet-derived growth factor stimulus, ephrin receptor signaling pathway, negative regulation of apoptotic process, negative regulation of cell adhesion, negative regulation of cell-matrix adhesion, positive regulation of D-glucose import, positive regulation of fibroblast proliferation, regulation of actin filament polymerization, regulation of intracellular signal transduction, response to xenobiotic stimulus, signal transduction, system development; MF: GTPase activator activity, GTPase binding, enzyme binding, kinase binding, phosphotyrosine residue binding, platelet-derived growth factor receptor binding, protein binding, protein kinase B binding, protein tyrosine kinase binding, protein-containing complex binding, receptor tyrosine kinase binding, signaling receptor binding, transmembrane transporter binding; CC: cytoplasm, cytosol, nuclear membrane, plasma membrane, ruffle
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, Downstream signal transduction, EPH-Ephrin signaling, EPHB-mediated forward signaling, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Nervous system development, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, RAF/MAP kinase cascade, Ras signaling pathway - Mus musculus (mouse), Regulation of RAS by GAPs, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PDGF, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, VEGFA-VEGFR2 Pathway, VEGFR2 mediated cell proliferation
UniProt: A0A286YDU0, E9PYG6
Entrez ID: 218397
|
Does Knockout of Atad2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,174
|
Knockout
|
Atad2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Atad2 (ATPase family, AAA domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly, nucleosome disassembly, positive regulation of DNA-templated transcription, transcription initiation-coupled chromatin remodeling; MF: ATP binding, ATP hydrolysis activity, chromatin binding, histone binding, hydrolase activity, nucleotide binding, protein binding; CC: nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
UniProt: Q8CDM1
Entrez ID: 70472
|
Does Knockout of Pold2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Pold2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Pold2 (polymerase (DNA directed), delta 2, regulatory subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA metabolic process, DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA-templated DNA replication, error-prone translesion synthesis; CC: delta DNA polymerase complex, nucleoplasm, nucleus, zeta DNA polymerase complex
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: O35654
Entrez ID: 18972
|
Does Knockout of Plekho1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Plekho1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Plekho1 (pleckstrin homology domain containing, family O member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lamellipodium morphogenesis, myoblast fusion, myoblast migration, regulation of cell shape, regulation of myoblast fusion; CC: cytoplasm, membrane, muscle cell projection membrane, nucleus, plasma membrane, ruffle membrane
Pathways:
UniProt: Q9JIY0
Entrez ID: 67220
|
Does Knockout of Rbm47 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Rbm47
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rbm47 (RNA binding motif protein 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, RNA splicing, cytidine to uridine editing, hematopoietic progenitor cell differentiation, low-density lipoprotein particle clearance, mRNA processing, positive regulation of interleukin-10 production, positive regulation of type I interferon-mediated signaling pathway, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, enzyme binding, enzyme-substrate adaptor activity, mRNA 3'-UTR binding, mRNA binding, nucleic acid binding, protein binding; CC: apolipoprotein B mRNA editing enzyme complex, cytoplasm, nucleus
Pathways:
UniProt: Q91WT8
Entrez ID: 245945
|
Does Knockout of Eif2b4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Eif2b4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eif2b4 (eukaryotic translation initiation factor 2B, subunit 4 delta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, animal organ development, central nervous system development, cytoplasmic translational initiation, myelination, oligodendrocyte development, ovarian follicle development, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of proteins, Recycling of eIF2:GDP, Translation
UniProt: Q61749
Entrez ID: 13667
|
Does Knockout of Stk11 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Stk11
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Stk11 (serine/threonine kinase 11)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: DNA damage response, G1 to G0 transition, Golgi localization, T cell receptor signaling pathway, anoikis, apoptotic process, autophagy, axonogenesis, cell differentiation, cellular response to UV-B, dendrite extension, establishment of cell polarity, glucose homeostasis, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of TORC1 signaling, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of cold-induced thermogenesis, negative regulation of epithelial cell proliferation involved in prostate gland development, positive regulation of autophagy, positive regulation of axonogenesis, positive regulation of gluconeogenesis, positive regulation of protein localization to nucleus, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of vesicle transport along microtubule, positive thymic T cell selection, protein autophosphorylation, protein dephosphorylation, protein phosphorylation, regulation of Wnt signaling pathway, regulation of cell growth, regulation of dendrite morphogenesis, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, response to ionizing radiation, response to lipid, signal transduction, spermatid development, spermatogenesis, tissue homeostasis, vasculature development; MF: ATP binding, LRR domain binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, p53 binding, protein binding, protein kinase activator activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: Z disc, centrosome, cilium, cytoplasm, cytosol, intracellular protein-containing complex, membrane, mitochondrion, nucleoplasm, nucleus, protein-containing complex, serine/threonine protein kinase complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Energy dependent regulation of mTOR by LKB1-AMPK, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Longevity regulating pathway - Mus musculus (mouse), MTOR signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, Tight junction - Mus musculus (mouse), Transcriptional Regulation by TP53, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9WTK7
Entrez ID: 20869
|
Does Knockout of Mlxip in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Mlxip
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mlxip (MLX interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleocytoplasmic transport, positive regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity; CC: RNA polymerase II transcription regulator complex, cytoplasm, membrane, mitochondrial outer membrane, mitochondrion, nucleus
Pathways: Insulin resistance - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse)
UniProt: Q2VPU4
Entrez ID: 208104
|
Does Knockout of D630023F18Rik in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
D630023F18Rik
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: D630023F18Rik (RIKEN cDNA D630023F18 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C3M9
Entrez ID: 98303
|
Does Knockout of Ctnna3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Ctnna3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ctnna3 (catenin alpha 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bundle of His cell-Purkinje myocyte adhesion involved in cell communication, cell adhesion, cell migration, cell-cell adhesion, regulation of heart rate by cardiac conduction, regulation of ventricular cardiac muscle cell action potential; MF: actin filament binding, beta-catenin binding, cadherin binding, protein binding; CC: adherens junction, anchoring junction, cytoplasm, cytoskeleton, desmosome, fascia adherens, lamellipodium
Pathways: Adherens junction - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Endometrial cancer - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: Q65CL1
Entrez ID: 216033
|
Does Knockout of Sstr2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Sstr2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Sstr2 (somatostatin receptor 2)
Type: protein-coding
Summary: The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several hormones and other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cellular response to estradiol stimulus, cellular response to glucocorticoid stimulus, neuropeptide signaling pathway, peristalsis, signal transduction, somatostatin signaling pathway; MF: G protein-coupled receptor activity, PDZ domain binding, neuropeptide binding, somatostatin receptor activity; CC: cytoplasm, cytosol, membrane, neuron projection, nucleoplasm, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Gastric acid secretion - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: P30875
Entrez ID: 20606
|
Does Knockout of Fbxo2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Fbxo2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fbxo2 (F-box protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, glycoprotein catabolic process, negative regulation of cell population proliferation, protein ubiquitination, regulation of protein catabolic process at postsynapse, modulating synaptic transmission, regulation of protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: amyloid-beta binding, carbohydrate binding, denatured protein binding, protein binding, ubiquitin protein ligase activity; CC: SCF ubiquitin ligase complex, cytoplasm, cytosol, dendritic spine, endoplasmic reticulum, extrinsic component of postsynaptic membrane, glutamatergic synapse, membrane
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q80UW2
Entrez ID: 230904
|
Does Knockout of Vti1a in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Vti1a
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Vti1a (vesicle transport through interaction with t-SNAREs 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to vacuole transport, autophagy, endocytic recycling, endoplasmic reticulum to Golgi vesicle-mediated transport, endosomal transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, macroautophagy, membrane fusion, protein transport, retrograde transport, endosome to Golgi, synaptic vesicle to endosome fusion, vesicle fusion with Golgi apparatus, vesicle-mediated transport, voluntary musculoskeletal movement; MF: SNAP receptor activity, SNARE binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, SNARE complex, autophagosome, bounding membrane of organelle, clathrin-coated vesicle, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum membrane, endosome, hippocampal mossy fiber to CA3 synapse, late endosome membrane, membrane, neuron projection terminus, neuronal cell body, perinuclear region of cytoplasm, synaptic vesicle, synaptic vesicle membrane
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, SNARE interactions in vesicular transport - Mus musculus (mouse), Vesicle-mediated transport
UniProt: O89116
Entrez ID: 53611
|
Does Knockout of Iglon5 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Iglon5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Iglon5 (IgLON family member 5)
Type: protein-coding
Summary: Acts upstream of or within motor behavior and neuromuscular process controlling balance. Predicted to be located in extracellular region. Is expressed in central nervous system; peripheral nervous system ganglion; and sensory organ. Orthologous to human IGLON5 (IgLON family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: motor behavior, neuromuscular process controlling balance
Pathways:
UniProt: Q8HW98
Entrez ID: 210094
|
Does Knockout of Strn3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Strn3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Strn3 (striatin, calmodulin binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of hippo signaling, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, response to estradiol; MF: armadillo repeat domain binding, calmodulin binding, protein phosphatase 2A binding, protein-containing complex binding, protein-macromolecule adaptor activity, small GTPase binding; CC: FAR/SIN/STRIPAK complex, Golgi apparatus, cytoplasm, dendrite, membrane, neuronal cell body, nucleoplasm, nucleus, plasma membrane, postsynapse, protein-containing complex
Pathways:
UniProt: Q9ERG2
Entrez ID: 94186
|
Does Knockout of Zranb1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Zranb1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Zranb1 (zinc finger, RAN-binding domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, autophagosome assembly, cell migration, cytoskeleton organization, phosphatidylinositol phosphate biosynthetic process, positive regulation of Wnt signaling pathway, protein K29-linked deubiquitination, protein K33-linked deubiquitination, protein K63-linked deubiquitination, protein deubiquitination, protein deubiquitination involved in ubiquitin-dependent protein catabolic process, proteolysis, regulation of cell morphogenesis; MF: K63-linked polyubiquitin modification-dependent protein binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, metal ion binding, peptidase activity, polyubiquitin modification-dependent protein binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Degradation of beta-catenin by the destruction complex, Deubiquitination, Metabolism of proteins, Ovarian tumor domain proteases, Post-translational protein modification, Signal Transduction, Signaling by WNT
UniProt: Q7M760
Entrez ID: 360216
|
Does Knockout of Rai14 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Rai14
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rai14 (retinoic acid induced 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, spermatogenesis; CC: anchoring junction, cell cortex, cytoplasm, cytoskeleton, cytosol, fibrillar center, mitochondrion, nucleoplasm, nucleus, stress fiber
Pathways:
UniProt: Q9EP71
Entrez ID: 75646
|
Does Knockout of Chmp4b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Chmp4b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Chmp4b (charged multivesicular body protein 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, membrane fission, midbody abscission, mitotic cytokinesis, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein transport, regulation of autophagy, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; MF: identical protein binding, protein binding, protein homodimerization activity; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endosome, endosome membrane, glutamatergic synapse, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, membrane coat, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleus, plasma membrane, postsynaptic density, vesicle
Pathways: Autophagy, Cell Cycle, Cell Cycle, Mitotic, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Mus musculus (mouse), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, Sealing of the nuclear envelope (NE) by ESCRT-III, Vesicle-mediated transport
UniProt: Q9D8B3
Entrez ID: 75608
|
Does Knockout of Tmem92 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Tmem92
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tmem92 (transmembrane protein 92)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, nucleoplasm
Pathways:
UniProt: B7ZWI3
Entrez ID: 544806
|
Does Knockout of Tmco3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Tmco3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmco3 (transmembrane and coiled-coil domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, monoatomic cation transport, monoatomic ion transport, potassium ion transmembrane transport, proton transmembrane transport, transmembrane transport; MF: antiporter activity, molecular_function, potassium:proton antiporter activity
Pathways:
UniProt: Q8BH01
Entrez ID: 234076
|
Does Knockout of Slc25a19 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Slc25a19
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Slc25a19 (solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19)
Type: protein-coding
Summary: Enables thiamine pyrophosphate transmembrane transporter activity. Involved in thiamine diphosphate biosynthetic process. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in central nervous system; embryo; retina inner nuclear layer; retina layer; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in inherited metabolic disorder and microcephaly. Orthologous to human SLC25A19 (solute carrier family 25 member 19). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: deoxynucleotide transport, thiamine diphosphate biosynthetic process, thiamine pyrophosphate transmembrane transport, thiamine-containing compound metabolic process, transmembrane transport; MF: antiporter activity, deoxynucleotide transmembrane transporter activity, thiamine pyrophosphate transmembrane transporter activity, thiamine transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Vitamin B1 (thiamin) metabolism
UniProt: Q9DAM5
Entrez ID: 67283
|
Does Knockout of Vmn2r80 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Vmn2r80
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vmn2r80 (vomeronasal 2, receptor 80)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, regulation of calcium ion transport, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: E9Q1L0
Entrez ID: 624765
|
Does Knockout of Gpr4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Gpr4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gpr4 (G protein-coupled receptor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, angiogenesis involved in wound healing, cellular response to acidic pH, glomerular mesangial cell development, negative regulation of angiogenesis, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of Rho protein signal transduction, positive regulation of inflammatory response, regulation of cell adhesion, regulation of vascular permeability, response to acidic pH, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Signal Transduction, Signaling by GPCR
UniProt: Q8BUD0
Entrez ID: 319197
|
Does Knockout of Rnf157 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Rnf157
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rnf157 (ring finger protein 157)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of apoptotic process, positive regulation of dendrite extension, protein ubiquitination; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cell body, cytoplasm
Pathways:
UniProt: F6XBS7, A2AAN9, A2AAP0, F7D0T8
Entrez ID: 217340
|
Does Knockout of I830077J02Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
I830077J02Rik
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: I830077J02Rik (RIKEN cDNA I830077J02 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q3U7U4
Entrez ID: 433638
|
Does Knockout of Siae in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Siae
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Siae (sialic acid acetylesterase)
Type: protein-coding
Summary: Predicted to enable sialate O-acetylesterase activity. Predicted to be involved in carbohydrate metabolic process and regulation of immune system process. Located in lysosome. Is expressed in several structures, including abdominal fat pad; central nervous system; genitourinary system; immune system; and yolk sac. Human ortholog(s) of this gene implicated in autoimmune disease. Orthologous to human SIAE (sialic acid acetylesterase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: carbohydrate metabolic process, regulation of immune system process; MF: carboxylic ester hydrolase activity, hydrolase activity, sialate 9-O-acetylesterase activity, sialate O-acetylesterase activity; CC: cytoplasm, lysosome
Pathways:
UniProt: P70665
Entrez ID: 22619
|
Does Knockout of E030030I06Rik in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
E030030I06Rik
|
protein/peptide accumulation
|
Mouse cell
|
Gene: E030030I06Rik (RIKEN cDNA E030030I06 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Copb1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Copb1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Copb1 (coatomer protein complex, subunit beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, protein transport, vesicle-mediated transport; CC: COPI vesicle coat, COPI-coated vesicle, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, Golgi-associated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum-Golgi intermediate compartment, membrane, membrane coat, plasma membrane
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9JIF7
Entrez ID: 70349
|
Does Knockout of Tbx3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Tbx3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tbx3 (T-box 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, anterior/posterior axis specification, embryo, atrioventricular bundle cell differentiation, atrioventricular canal development, atrioventricular canal morphogenesis, blood vessel development, branching involved in mammary gland duct morphogenesis, cardiac epithelial to mesenchymal transition, cardiac jelly development, cardiac muscle cell differentiation, cardiac muscle cell fate commitment, cell fate specification, cellular senescence, embryonic digit morphogenesis, embryonic forelimb morphogenesis, embryonic heart tube development, embryonic hindlimb morphogenesis, endocardial cushion formation, female genitalia development, follicle-stimulating hormone secretion, forelimb morphogenesis, heart looping, heart morphogenesis, hepatoblast differentiation, in utero embryonic development, inner ear morphogenesis, limb morphogenesis, limbic system development, luteinizing hormone secretion, male genitalia development, mammary gland development, mammary placode formation, mesoderm morphogenesis, muscle cell fate commitment, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell proliferation involved in heart morphogenesis, negative regulation of epithelial cell differentiation, negative regulation of myoblast differentiation, negative regulation of stem cell differentiation, negative regulation of transcription by RNA polymerase II, outflow tract morphogenesis, positive regulation of DNA-templated transcription, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell population proliferation, regulation of protein complex stability, regulation of protein stability, regulation of transcription by RNA polymerase II, roof of mouth development, semicircular canal morphogenesis, sinoatrial node cell development, skeletal system development, smooth muscle cell differentiation, specification of animal organ position, stem cell population maintenance, ureteric peristalsis, ventricular septum morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, cilium, nucleus
Pathways: Developmental Biology, MITF-M-regulated melanocyte development, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Transcriptional and post-translational regulation of MITF-M expression and activity
UniProt: P70324
Entrez ID: 21386
|
Does Knockout of Mc4r in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Mc4r
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mc4r (melanocortin 4 receptor)
Type: protein-coding
Summary: This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased cholesterol levels and insulin resistance. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, diet induced thermogenesis, energy reserve metabolic process, feeding behavior, insulin secretion, negative regulation of feeding behavior, positive regulation of bone resorption, regulation of eating behavior, regulation of feeding behavior, regulation of grooming behavior, response to food, response to insulin, response to melanocyte-stimulating hormone, signal transduction; MF: G protein-coupled receptor activity, hormone binding, melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, metal ion binding, neuropeptide binding, peptide hormone binding, protein binding, ubiquitin protein ligase binding; CC: cytoplasm, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: P56450
Entrez ID: 17202
|
Does Knockout of Ltk in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Ltk
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Ltk (leukocyte tyrosine kinase)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell population proliferation, cell surface receptor protein tyrosine kinase signaling pathway, cellular response to retinoic acid, negative regulation of apoptotic process, peptidyl-tyrosine autophosphorylation, positive regulation of cardiac muscle cell apoptotic process, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of cell population proliferation, regulation of neuron differentiation; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, receptor signaling protein tyrosine kinase activator activity, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: endoplasmic reticulum, membrane, plasma membrane, receptor complex
Pathways: Signal Transduction, Signaling by LTK, Signaling by Receptor Tyrosine Kinases, starch degradation, sucrose degradation
UniProt: P08923
Entrez ID: 17005
|
Does Knockout of Msmo1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Msmo1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Msmo1 (methylsterol monoxygenase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, lipid biosynthetic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: C-4 methylsterol oxidase activity, iron ion binding, oxidoreductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, Steroid biosynthesis - Mus musculus (mouse), cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), superpathway of cholesterol biosynthesis
UniProt: Q9CRA4
Entrez ID: 66234
|
Does Knockout of Mtpap in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Mtpap
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mtpap (mitochondrial poly(A) polymerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, RNA metabolic process, histone mRNA catabolic process, mRNA processing, mitochondrial RNA 3'-end processing, mitochondrial mRNA polyadenylation; MF: ATP binding, RNA binding, UTP binding, identical protein binding, magnesium ion binding, manganese ion binding, metal ion binding, nucleotide binding, poly(A) RNA polymerase activity, protein homodimerization activity, transferase activity; CC: cytoplasm, mitochondrion, nucleoplasm
Pathways:
UniProt: Q9D0D3
Entrez ID: 67440
|
Does Knockout of Acadvl in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Acadvl
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Acadvl (acyl-Coenzyme A dehydrogenase, very long chain)
Type: protein-coding
Summary: This gene encodes a homodimeric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C16- and C20-acylCoA and localizes to the inner mitochondrial membrane (unlike related acyl-CoA dehydrogenases). In mice, deficiency of this gene can cause ventricular arrhythmias as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: epithelial cell differentiation, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty acid catabolic process, fatty acid metabolic process, lipid metabolic process, negative regulation of fatty acid biosynthetic process, negative regulation of fatty acid oxidation, regulation of cholesterol metabolic process, response to cold, temperature homeostasis; MF: acyl-CoA dehydrogenase activity, fatty-acyl-CoA binding, flavin adenine dinucleotide binding, identical protein binding, long-chain fatty acyl-CoA dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, very-long-chain fatty acyl-CoA dehydrogenase activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrial nucleoid, mitochondrion, nucleolus, nucleoplasm
Pathways: Alcoholic liver disease - Mus musculus (mouse), Beta oxidation of palmitoyl-CoA to myristoyl-CoA, Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, fatty acid β-oxidation I, mitochondrial fatty acid beta-oxidation of saturated fatty acids
UniProt: P50544
Entrez ID: 11370
|
Does Knockout of Phf23 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Phf23
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Phf23 (PHD finger protein 23)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; and limb. Orthologous to human PHF23 (PHD finger protein 23). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: autophagy, negative regulation of autophagosome assembly, negative regulation of autophagosome maturation, positive regulation of protein ubiquitination; MF: metal ion binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8BSN5
Entrez ID: 78246
|
Does Knockout of Smox in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Smox
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Smox (spermine oxidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: polyamine catabolic process, spermine catabolic process; MF: oxidoreductase activity, polyamine oxidase activity, spermine oxidase activity; CC: cytoplasm, cytosol, nuclear membrane, nucleoplasm, nucleus
Pathways: Amine Oxidase reactions, Arginine and proline metabolism - Mus musculus (mouse), Biological oxidations, Interconversion of polyamines, Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, PAOs oxidise polyamines to amines, Phase I - Functionalization of compounds, beta-Alanine metabolism - Mus musculus (mouse)
UniProt: Q99K82
Entrez ID: 228608
|
Does Knockout of Setd3 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Setd3
|
response to virus
|
Microglial Cell Line
|
Gene: Setd3 (SET domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin modification, chromatin remodeling, methylation, peptidyl-histidine methylation, positive regulation of DNA-templated transcription, positive regulation of muscle cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of uterine smooth muscle contraction; MF: RNA polymerase II-specific DNA-binding transcription factor binding, actin binding, histone H3K36 methyltransferase activity, histone H3K4 methyltransferase activity, methyltransferase activity, protein-L-histidine N-tele-methyltransferase activity, transcription coactivator activity, transferase activity; CC: chromatin, cytoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, PKMTs methylate histone lysines
UniProt: Q91WC0
Entrez ID: 52690
|
Does Knockout of Dbf4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Dbf4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dbf4 (DBF4 zinc finger)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, positive regulation of nuclear cell cycle DNA replication, regulation of cell cycle phase transition, traversing start control point of mitotic cell cycle; MF: metal ion binding, nucleic acid binding, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, zinc ion binding; CC: Dbf4-dependent protein kinase complex, nuclear body, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition
UniProt: Q9QZ41
Entrez ID: 27214
|
Does Knockout of Extl2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Extl2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Extl2 (exostosin-like glycosyltransferase 2)
Type: protein-coding
Summary: Enables acetylgalactosaminyltransferase activity; glycosaminoglycan binding activity; and manganese ion binding activity. Involved in N-acetylglucosamine metabolic process and UDP-N-acetylgalactosamine metabolic process. Predicted to be located in cytosol; endoplasmic reticulum; and nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Orthologous to human EXTL2 (exostosin like glycosyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: N-acetylglucosamine metabolic process, UDP-N-acetylgalactosamine metabolic process; MF: alpha-1,4-N-acetylgalactosaminyltransferase activity, glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity, glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity, glycosaminoglycan binding, glycosyltransferase activity, manganese ion binding, metal ion binding, transferase activity; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm
Pathways: Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: Q9ES89
Entrez ID: 58193
|
Does Knockout of Pcdha5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Pcdha5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcdha5 (protocadherin alpha 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q91Y15
Entrez ID: 12941
|
Does Knockout of Ranbp3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ranbp3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ranbp3 (RAN binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein export from nucleus, protein transport; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Human T-cell leukemia virus 1 infection - Mus musculus (mouse)
UniProt: Q9CT10
Entrez ID: 71810
|
Does Knockout of Zfp300 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Zfp300
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp300 (zinc finger protein 300)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of macromolecule biosynthetic process, regulation of DNA-templated transcription; MF: DNA binding, metal ion binding, zinc ion binding
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: A2AE21, Q8C6W5
Entrez ID: 245368
|
Does Knockout of Ccdc69 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Ccdc69
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ccdc69 (coiled-coil domain containing 69)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: spindle midzone assembly; CC: cytoplasm, cytoskeleton, midbody, nucleus, spindle, spindle midzone
Pathways:
UniProt: Q3TCJ8
Entrez ID: 52570
|
Does Knockout of Ahcy in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Ahcy
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ahcy (S-adenosylhomocysteine hydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: S-adenosylhomocysteine catabolic process, S-adenosylmethionine cycle, S-methylmethionine cycle, chronic inflammatory response to antigenic stimulus, circadian sleep/wake cycle, one-carbon metabolic process, response to nutrient; MF: NAD binding, adenosylhomocysteinase activity, adenyl nucleotide binding, copper ion binding, hydrolase activity, identical protein binding, protein binding; CC: cytoplasm, cytosol, endoplasmic reticulum, melanosome, nucleus
Pathways: <i>S</i>-adenosyl-L-methionine cycle II, Biological oxidations, Cysteine and methionine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Methylation, Phase II - Conjugation of compounds, Sulfur amino acid metabolism, cysteine biosynthesis III (mammalia), methionine degradation I (to homocysteine), superpathway of methionine degradation
UniProt: P50247
Entrez ID: 269378
|
Does Knockout of Emsy in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Emsy
|
cell cycle progression
|
breast epithelium
|
Gene: Emsy (EMSY, BRCA2-interacting transcriptional repressor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, regulation of DNA-templated transcription; MF: identical protein binding, protein binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q8BMB0
Entrez ID: 233545
|
Does Knockout of Wnt7b in Regulatory T cell causally result in protein/peptide accumulation?
| 1
| 1,482
|
Knockout
|
Wnt7b
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Wnt7b (wingless-type MMTV integration site family, member 7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, Wnt signaling pathway, planar cell polarity pathway, anatomical structure regression, angiogenesis, animal organ morphogenesis, apoptotic process involved in blood vessel morphogenesis, canonical Wnt signaling pathway, cell differentiation, cell fate commitment, cell proliferation in forebrain, central nervous system vasculogenesis, chemoattraction of dopaminergic neuron axon, chorio-allantoic fusion, developmental growth involved in morphogenesis, embryonic organ development, embryonic placenta morphogenesis, establishment or maintenance of polarity of embryonic epithelium, forebrain regionalization, homeostatic process, in utero embryonic development, inner medullary collecting duct development, intracellular oxygen homeostasis, lobar bronchus development, lung development, lung epithelium development, lung morphogenesis, lung-associated mesenchyme development, metanephric collecting duct development, metanephric epithelium development, metanephric loop of Henle development, metanephros morphogenesis, negative regulation of neurogenesis, negative regulation of smoothened signaling pathway, neuron differentiation, neuron projection development, neuron projection morphogenesis, odontogenesis of dentin-containing tooth, outer medullary collecting duct development, positive regulation of JNK cascade, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of osteoblast differentiation, regulation of cell projection size, renal inner medulla development, renal outer medulla development, smooth muscle cell differentiation, stem cell development, synapse organization, system development, tissue development, trachea cartilage morphogenesis, vasculature development; MF: chemoattractant activity involved in axon guidance, cytokine activity, frizzled binding, receptor ligand activity, signaling receptor binding; CC: cell surface, endoplasmic reticulum lumen, extracellular region, extracellular space
Pathways: Alzheimer disease - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), WNT ligand biogenesis and trafficking, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P28047
Entrez ID: 22422
|
Does Knockout of Zxdc in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Zxdc
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Zxdc (ZXD family zinc finger C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: C2H2 zinc finger domain binding, LRR domain binding, metal ion binding, transcription coactivator activity, transcription coregulator activity, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8C8V1
Entrez ID: 80292
|
Does Knockout of Cecr2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Cecr2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cecr2 (CECR2, histone acetyl-lysine reader)
Type: protein-coding
Summary: Predicted to enable ATP-dependent chromatin remodeler activity. Acts upstream of or within inner ear development; primary neural tube formation; and single fertilization. Located in euchromatin and nucleus. Part of CERF complex. Is expressed in several structures, including extraembryonic component; genitourinary system; and olfactory epithelium. Used to study anencephaly. Orthologous to human CECR2 (CECR2 histone acetyl-lysine reader). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromatin organization, chromatin remodeling, cochlea development, execution phase of apoptosis, inner ear receptor cell stereocilium organization, neural fold formation, neural tube closure, neural tube development, single fertilization; MF: ATP-dependent chromatin remodeler activity, protein binding; CC: CERF complex, ISWI-type complex, euchromatin, nucleus
Pathways:
UniProt: E9Q2Z1
Entrez ID: 330409
|
Does Knockout of Traf4 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Traf4
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Traf4 (TNF receptor associated factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cell surface receptor signaling pathway, immune system process, innate immune response, positive regulation of JNK cascade, positive regulation of protein kinase activity, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of apoptotic process, regulation of canonical NF-kappaB signal transduction, respiratory gaseous exchange by respiratory system, respiratory tube development, signal transduction; MF: WW domain binding, enzyme binding, identical protein binding, metal ion binding, protein kinase binding, signaling adaptor activity, thioesterase binding, transferase activity, tumor necrosis factor receptor binding, ubiquitin protein ligase binding, zinc ion binding; CC: anchoring junction, bicellular tight junction, cytoplasm, cytoskeleton, cytosol, fibrillar center, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: IL-17 signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse)
UniProt: Q61382
Entrez ID: 22032
|
Does Knockout of Spata17 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Spata17
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Spata17 (spermatogenesis associated 17)
Type: protein-coding
Summary: Predicted to enable calmodulin binding activity. Predicted to be located in cytoplasm. Orthologous to human SPATA17 (spermatogenesis associated 17). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: calmodulin binding, molecular_function; CC: cellular_component, cytoplasm
Pathways:
UniProt: Q9D552
Entrez ID: 74717
|
Does Knockout of Zfp618 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Zfp618
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp618 (zinc finger protein 618)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, chromatin-protein adaptor activity, identical protein binding, metal ion binding, transcription coregulator binding, zinc ion binding; CC: chromatin, chromosome, nucleus, pericentric heterochromatin
Pathways:
UniProt: Q80YY7
Entrez ID: 72701
|
Does Knockout of Ppp2ca in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ppp2ca
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ppp2ca (protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, T cell homeostasis, meiotic cell cycle, mesoderm development, mitotic cell cycle, negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial to mesenchymal transition, negative regulation of glycolytic process through fructose-6-phosphate, negative regulation of hippo signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of glycolytic process through fructose-6-phosphate, protein dephosphorylation, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, regulation of protein catabolic process, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: GABA receptor binding, RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity, beta-2 adrenergic receptor binding, enzyme binding, hydrolase activity, identical protein binding, metal ion binding, phosphoprotein phosphatase activity, protein antigen binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein kinase B binding, protein kinase binding, protein phosphatase 2A binding, protein phosphatase binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein-containing complex binding, tau protein binding, transmembrane transporter binding; CC: FAR/SIN/STRIPAK complex, INTAC complex, chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, membrane raft, nucleus, plasma membrane, protein phosphatase type 2A complex, protein serine/threonine phosphatase complex, spindle pole, synapse, terminal bouton
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Antiviral mechanism by IFN-stimulated genes, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Beta-catenin phosphorylation cascade, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chagas disease - Mus musculus (mouse), Co-inhibition by CTLA4, Co-stimulation by CD28, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin D associated events in G1, Cytokine Signaling in Immune system, DARPP-32 events, Degradation of beta-catenin by the destruction complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Dopaminergic synapse - Mus musculus (mouse), E2F mediated regulation of DNA replication, EML4 and NUDC in mitotic spindle formation, ERK/MAPK targets, ERKs are inactivated, G alpha (i) signalling events, G1 Phase, G1/S Transition, G2/M Transition, GPCR downstream signalling, Gene expression (Transcription), Generic Transcription Pathway, Hemostasis, Hepatitis C - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Inhibition of replication initiation of damaged DNA by RB1/E2F1, Initiation of Nuclear Envelope (NE) Reformation, Innate Immune System, Interferon Signaling, Interleukin-17 signaling, Intracellular signaling by second messengers, Long-term depression - Mus musculus (mouse), M Phase, MAP kinase activation, MAPK family signaling cascades, MAPK targets/ Nuclear events mediated by MAP kinases, MAPK1/MAPK3 signaling, Metabolism of RNA, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of MAPK pathway, Negative regulation of the PI3K/AKT network, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear Envelope (NE) Reassembly, Nuclear Events (kinase and transcription factor activation), Oocyte meiosis - Mus musculus (mouse), Opioid Signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PKR-mediated signaling, Platelet homeostasis, Platelet sensitization by LDL, RAF activation, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Resolution of Sister Chromatid Cohesion, Response of endothelial cells to shear stress, Separation of Sister Chromatids, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Sphingolipid signaling pathway - Mus musculus (mouse), Spry regulation of FGF signaling, TCF dependent signaling in response to WNT, TGF-beta signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Tight junction - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcriptional Regulation by TP53, Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: P63330
Entrez ID: 19052
|
Does Knockout of Smyd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Smyd1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Smyd1 (SET and MYND domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, heart development, methylation, negative regulation of DNA-templated transcription, positive regulation of myoblast differentiation, positive regulation of myotube differentiation, skeletal muscle cell differentiation; MF: DNA binding, histone H3K4 methyltransferase activity, histone H3K4 trimethyltransferase activity, metal ion binding, methyltransferase activity, protein binding, transcription corepressor activity, transferase activity, zinc ion binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Lysine degradation - Mus musculus (mouse)
UniProt: P97443
Entrez ID: 12180
|
Does Knockout of B2m in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
B2m
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: B2m (beta-2 microglobulin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation in thymus, amyloid fibril formation, antibacterial humoral response, antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent, antigen processing and presentation of peptide antigen via MHC class I, antimicrobial humoral immune response mediated by antimicrobial peptide, cellular defense response, cellular response to iron ion, cellular response to iron(III) ion, cellular response to lipopolysaccharide, cellular response to nicotine, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, immune response, immune system process, innate immune response, intracellular iron ion homeostasis, iron ion transport, learning or memory, multicellular organismal-level iron ion homeostasis, negative regulation of epithelial cell proliferation, negative regulation of forebrain neuron differentiation, negative regulation of iron ion transport, negative regulation of neurogenesis, negative regulation of neuron projection development, negative regulation of receptor-mediated endocytosis, peptide antigen assembly with MHC class I protein complex, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of T cell cytokine production, positive regulation of T cell mediated cytotoxicity, positive regulation of cellular senescence, positive regulation of immune response, positive regulation of receptor-mediated endocytosis, protein homotetramerization, protein refolding, regulation of erythrocyte differentiation, regulation of iron ion transport, regulation of membrane depolarization, response to metal ion, response to molecule of bacterial origin, sensory perception of smell, transferrin transport; MF: MHC class II protein complex binding, identical protein binding, peptide antigen binding, protein binding, protein homodimerization activity, structural molecule activity; CC: Golgi apparatus, HFE-transferrin receptor complex, MHC class I peptide loading complex, MHC class I protein complex, MHC class II protein complex, cytosol, external side of plasma membrane, extracellular region, extracellular space, late endosome membrane, lysosomal membrane, phagocytic vesicle membrane, plasma membrane
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, DAP12 interactions, DAP12 signaling, ER-Phagosome pathway, Endosomal/Vacuolar pathway, Epstein-Barr virus infection - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Neutrophil degranulation
UniProt: P01887
Entrez ID: 12010
|
Does Knockout of 1700020A23Rik in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
1700020A23Rik
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: 1700020A23Rik (RIKEN cDNA 1700020A23 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q9DA59
Entrez ID: 75656
|
Does Knockout of Amigo1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Amigo1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Amigo1 (adhesion molecule with Ig like domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonal fasciculation, axonogenesis, brain development, cell adhesion, cell differentiation, cellular response to L-glutamate, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, myelination, nervous system development, neuron projection fasciculation, positive regulation of axonogenesis, positive regulation of cellular component organization, positive regulation of nervous system development, positive regulation of neuron projection development, positive regulation of potassium ion transmembrane transport, positive regulation of synapse assembly; MF: potassium channel regulator activity, protein binding; CC: cell projection, dendrite, membrane, neuron projection, neuronal cell body, neuronal cell body membrane, pericellular basket, perikaryon, plasma membrane, voltage-gated potassium channel complex
Pathways:
UniProt: Q80ZD8
Entrez ID: 229715
|
Does Knockout of Pcdh1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Pcdh1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Pcdh1 (protocadherin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, protein binding; CC: cell junction, cell-cell junction, membrane, nucleolus, nucleoplasm, plasma membrane
Pathways:
UniProt: A0A0A6YX79, Q8CFX3, A0A0A6YY88, F7BJK1, E0CXD4
Entrez ID: 75599
|
Does Knockout of Kif18b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Kif18b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kif18b (kinesin family member 18B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule depolymerization, microtubule-based movement, mitotic cell cycle, mitotic sister chromatid segregation, regulation of cell division; MF: ATP binding, ATP hydrolysis activity, cytoskeletal motor activity, kinesin binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity; CC: astral microtubule, cytoplasm, cytoskeleton, cytosol, kinesin complex, microtubule, microtubule end, microtubule plus-end, mitotic spindle astral microtubule, mitotic spindle midzone, nuclear body, nucleolus, nucleoplasm, nucleus, spindle
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q6PFD6
Entrez ID: 70218
|
Does Knockout of Bsn in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Bsn
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Bsn (bassoon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axo-dendritic transport, maintenance of presynaptic active zone structure, modulation of chemical synaptic transmission, presynaptic active zone assembly, presynaptic active zone organization, protein localization to synapse, regulation of synaptic vesicle cycle, retrograde axonal transport, synapse organization, synaptic vesicle clustering; MF: dynein light chain binding, enzyme inhibitor activity, metal ion binding, protein binding, structural constituent of presynaptic active zone, transcription corepressor binding, zinc ion binding; CC: GABA-ergic synapse, Golgi-associated vesicle, Schaffer collateral - CA1 synapse, axon, axon cytoplasm, cell cortex, cell projection, cell surface, cochlear hair cell ribbon synapse, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytoskeleton of presynaptic active zone, cytosol, dendrite, excitatory synapse, extrinsic component of membrane, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, inhibitory synapse, neuron projection terminus, neuronal cell body, organelle, piccolo-bassoon transport vesicle, postsynaptic density, presynapse, presynaptic active zone, presynaptic active zone cytoplasmic component, ribbon synapse, synapse, synaptic membrane, synaptic vesicle, trans-Golgi network
Pathways:
UniProt: O88737
Entrez ID: 12217
|
Does Knockout of Vmn1r216 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Vmn1r216
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmn1r216 (vomeronasal 1 receptor 216)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8R257
Entrez ID: 171279
|
Does Knockout of Ubtf in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Ubtf
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ubtf (upstream binding transcription factor, RNA polymerase I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, cellular response to leukemia inhibitory factor, positive regulation of transcription by RNA polymerase I, rDNA heterochromatin formation, transcription by RNA polymerase I, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase I promoter; MF: DNA binding, RNA polymerase I cis-regulatory region sequence-specific DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, RNA polymerase I general transcription initiation factor activity, chromatin binding, protein binding, scaffold protein binding; CC: fibrillar center, nucleolus, nucleus
Pathways:
UniProt: A2AWT5, A2AWT6, E9Q4A8, A2AWT7, Q9DBH1, G3UZW9
Entrez ID: 21429
|
Does Knockout of Ppp1r14d in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Ppp1r14d
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ppp1r14d (protein phosphatase 1, regulatory inhibitor subunit 14D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein phosphatase inhibitor activity, protein serine/threonine phosphatase inhibitor activity; CC: cellular_component, cytoplasm
Pathways:
UniProt: Q7TT52
Entrez ID: 72112
|
Does Knockout of A830035O19Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
A830035O19Rik
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: A830035O19Rik (RIKEN cDNA A830035O19 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100101457
|
Does Knockout of D930020B18Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
D930020B18Rik
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: D930020B18Rik (RIKEN cDNA D930020B18 gene)
Type: protein-coding
Summary: Is expressed in epididymis; olfactory epithelium; and vomeronasal organ. Orthologous to human C12orf56 (chromosome 12 open reading frame 56). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: D6RIN2, D3Z3G0, D3YXS3, F6XLN3
Entrez ID: 216393
|
Does Knockout of Gar1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Gar1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gar1 (GAR1 ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: pseudouridine synthesis, rRNA processing, ribosome biogenesis, snoRNA guided rRNA pseudouridine synthesis, telomere maintenance via telomerase; MF: RNA binding, box H/ACA snoRNA binding, protein binding, snoRNA binding, telomerase RNA binding; CC: Cajal body, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, chromosome, telomeric region, dense fibrillar component, fibrillar center, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q9CY66
Entrez ID: 68147
|
Does Knockout of Zfp566 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Zfp566
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp566 (zinc finger protein 566)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8VCI1
Entrez ID: 72556
|
Does Knockout of Phf5a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Phf5a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Phf5a (PHD finger protein 5A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, positive regulation of DNA-templated transcription, stem cell differentiation; MF: DNA binding, RNA binding, metal ion binding, protein binding, zinc ion binding; CC: U12-type spliceosomal complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, nuclear matrix, nuclear speck, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P83870
Entrez ID: 68479
|
Does Knockout of Stat2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Stat2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Stat2 (signal transducer and activator of transcription 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, defense response, defense response to virus, negative regulation of type I interferon-mediated signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell population proliferation, regulation of mitochondrial fission, regulation of protein phosphorylation, regulation of transcription by RNA polymerase II, response to peptide hormone, signal transduction, type I interferon-mediated signaling pathway; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein binding, ubiquitin-like protein ligase binding; CC: ISGF3 complex, cytoplasm, cytosol, nucleus, plasma membrane
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: Q9QXJ2
Entrez ID: 20847
|
Does Knockout of Fdxr in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Fdxr
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fdxr (ferredoxin reductase)
Type: protein-coding
Summary: Predicted to enable NADPH binding activity and ferredoxin-NADP+ reductase activity. Predicted to be involved in steroid biosynthetic process. Located in mitochondrial inner membrane. Orthologous to human FDXR (ferredoxin reductase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cholesterol metabolic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, ubiquinone biosynthetic process; MF: ferredoxin-NADP+ reductase activity, oxidoreductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Biological oxidations, Cytochrome P450 - arranged by substrate type, Electron transport from NADPH to Ferredoxin, Endogenous sterols, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Mitochondrial iron-sulfur cluster biogenesis, Phase I - Functionalization of compounds, Pregnenolone biosynthesis
UniProt: Q61578
Entrez ID: 14149
|
Does Knockout of Rit2 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Rit2
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Rit2 (Ras-like without CAAX 2)
Type: protein-coding
Summary: Enables several functions, including GTP binding activity; GTPase activity; and calmodulin binding activity. Involved in several processes, including Ras protein signal transduction; regulation of Cdc42 protein signal transduction; and regulation of neuron projection development. Located in several cellular components, including cell body; dendritic tree; and nucleus. Is expressed in central nervous system; lung; and neural retina. Orthologous to human RIT2 (Ras like without CAAX 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: MAPK cascade, Ras protein signal transduction, adenylate cyclase-activating G protein-coupled receptor signaling pathway, intracellular signal transduction, maintenance of protein location in cell, negative regulation of neuron projection development, positive regulation of MAPK cascade, positive regulation of neuron projection development, positive regulation of transcription by RNA polymerase II, regulation of Cdc42 protein signal transduction, regulation of ERK1 and ERK2 cascade, regulation of calcium-mediated signaling, regulation of endocytosis, signal transduction; MF: G protein activity, GDP binding, GTP binding, GTPase activity, calmodulin binding, chromatin binding, hydrolase activity, nucleotide binding, protein binding, semaphorin receptor binding; CC: Golgi apparatus, cell body, cytoplasm, cytosol, dendritic tree, membrane, membrane raft, neuron projection, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: P70425
Entrez ID: 19762
|
Does Knockout of Grik4 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Grik4
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Grik4 (glutamate receptor, ionotropic, kainate 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ionotropic glutamate receptor signaling pathway, modulation of chemical synaptic transmission, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of postsynaptic membrane potential, regulation of presynaptic membrane potential, synaptic transmission, glutamatergic; MF: glutamate-gated receptor activity, kainate selective glutamate receptor activity, ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, monoatomic ion channel activity, protein binding, signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: axon, cell projection, dendrite, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, kainate selective glutamate receptor complex, membrane, perikaryon, plasma membrane, postsynapse, postsynaptic density membrane, postsynaptic membrane, presynaptic membrane, synapse, terminal bouton
Pathways: Activation of Ca-permeable Kainate Receptor, Activation of kainate receptors upon glutamate binding, Glutamatergic synapse - Mus musculus (mouse), Ionotropic activity of kainate receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Transmission across Chemical Synapses
UniProt: Q8BMF5
Entrez ID: 110637
|
Does Knockout of Nrbp1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Nrbp1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nrbp1 (nuclear receptor binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, epithelial cell differentiation, epithelial cell proliferation, in utero embryonic development, intracellular signal transduction; MF: ATP binding, identical protein binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity; CC: cell cortex, cell projection, cytoplasm, endomembrane system, lamellipodium, membrane, perinuclear region of cytoplasm
Pathways:
UniProt: Q99J45
Entrez ID: 192292
|
Does Knockout of Cdhr5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Cdhr5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cdhr5 (cadherin-related family member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brush border assembly, cell adhesion, cell differentiation, cell-cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, intermicrovillar adhesion, regulation of microvillus length; MF: beta-catenin binding, calcium ion binding, cell adhesion molecule binding; CC: apical plasma membrane, brush border membrane, cell projection, clathrin-coated pit, membrane, microvillus, microvillus membrane, plasma membrane, synapse
Pathways:
UniProt: Q8VHF2
Entrez ID: 72040
|
Does Knockout of Prl2a1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Prl2a1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Prl2a1 (prolactin family 2, subfamily a, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels; MF: hormone activity, prolactin receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9JHK0
Entrez ID: 56635
|
Does Knockout of Fkbp2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Fkbp2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fkbp2 (FK506 binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: isomerase activity, peptidyl-prolyl cis-trans isomerase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: P45878
Entrez ID: 14227
|
Does Knockout of Luc7l3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Luc7l3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Luc7l3 (LUC7-like 3 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splice site recognition; MF: DNA binding, mRNA binding; CC: U1 snRNP, U2-type prespliceosome, nuclear speck, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q5SUF2
Entrez ID: 67684
|
Does Knockout of Cdk4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Cdk4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cdk4 (cyclin dependent kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, cellular response to interleukin-4, cellular response to ionomycin, cellular response to lipopolysaccharide, cellular response to phorbol 13-acetate 12-myristate, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of apoptotic process, positive regulation of cell population proliferation, positive regulation of cell size, positive regulation of epithelial cell proliferation, positive regulation of fibroblast proliferation, positive regulation of translation, regulation of G2/M transition of mitotic cell cycle, regulation of cell cycle, regulation of gene expression, regulation of type B pancreatic cell proliferation, response to testosterone, response to xenobiotic stimulus, signal transduction; MF: ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: bicellular tight junction, chromatin, cyclin D1-CDK4 complex, cyclin D2-CDK4 complex, cyclin D3-CDK4 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, transcription regulator complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adaptive Immune System, Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Chromatin modifying enzymes, Chromatin organization, Chronic myeloid leukemia - Mus musculus (mouse), Co-inhibition by PD-1, Cushing syndrome - Mus musculus (mouse), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Developmental Biology, Drug-mediated inhibition of CDK4/CDK6 activity, Epstein-Barr virus infection - Mus musculus (mouse), G1 Phase, G1/S Transition, Gene expression (Transcription), Generic Transcription Pathway, Glioma - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Non-small cell lung cancer - Mus musculus (mouse), Oncogene Induced Senescence, Oxidative Stress Induced Senescence, PI3K-Akt signaling pathway - Mus musculus (mouse), PTK6 Regulates Cell Cycle, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Senescence-Associated Secretory Phenotype (SASP), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Small cell lung cancer - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Transcriptional regulation by RUNX2, Transcriptional regulation of granulopoiesis, Ubiquitin-dependent degradation of Cyclin D, Viral carcinogenesis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P30285
Entrez ID: 12567
|
Does Knockout of A930003A15Rik in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
A930003A15Rik
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: A930003A15Rik (RIKEN cDNA A930003A15 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Dnlz in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Dnlz
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dnlz (DNL-type zinc finger)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chaperone-mediated protein complex assembly, protein folding, protein import into mitochondrial matrix, protein stabilization; MF: metal ion binding, protein folding chaperone, protein-folding chaperone binding, zinc ion binding; CC: cytosol, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q9D113
Entrez ID: 52838
|
Does Knockout of Ptger4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Ptger4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ptger4 (prostaglandin E receptor 4 (subtype EP4))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERK1 and ERK2 cascade, G protein-coupled receptor signaling pathway, JNK cascade, MAPK cascade, T-helper cell differentiation, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, bone development, cAMP biosynthetic process, cAMP/PKA signal transduction, cellular response to mechanical stimulus, cellular response to prostaglandin E stimulus, chemokinesis, ductus arteriosus closure, inflammatory response, negative regulation of cytokine production, negative regulation of ductus arteriosus closure, negative regulation of endothelin production, negative regulation of eosinophil extravasation, negative regulation of inflammatory response, negative regulation of integrin activation, negative regulation of interleukin-1 alpha production, negative regulation of peptide secretion, negative regulation of small intestine smooth muscle contraction, negative regulation of tumor necrosis factor production, positive regulation of antral ovarian follicle growth, positive regulation of bone resorption, positive regulation of calcitonin secretion, positive regulation of cell adhesion, positive regulation of cell population proliferation, positive regulation of chemokinesis, positive regulation of circadian sleep/wake cycle, non-REM sleep, positive regulation of cytokine production, positive regulation of cytosolic calcium ion concentration, positive regulation of gene expression, positive regulation of hyaluronan biosynthetic process, positive regulation of inflammatory response, positive regulation of interleukin-10 production, positive regulation of interleukin-8 production, positive regulation of matrix metallopeptidase secretion, positive regulation of mucus secretion, positive regulation of neutrophil extravasation, positive regulation of ossification, positive regulation of osteoblast differentiation, positive regulation of ovarian follicle development, positive regulation of protein secretion, positive regulation of smooth muscle cell migration, positive regulation of substance P secretion, positive regulation of substance P secretion, neurotransmission, positive regulation of urine volume, positive regulation of wound healing, regulation of circadian sleep/wake cycle, wakefulness, regulation of ossification, regulation of stress fiber assembly, response to lipid, response to lipopolysaccharide, response to nematode, response to prostaglandin E, signal transduction; MF: G protein-coupled receptor activity, prostaglandin E receptor activity, prostaglandin receptor activity; CC: membrane, neuron projection terminus, neuronal cell body, nuclear membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prostanoid ligand receptors, Renin secretion - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P32240
Entrez ID: 19219
|
Does Knockout of Hoxb9 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Hoxb9
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Hoxb9 (homeobox B9)
Type: protein-coding
Summary: Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic skeletal system development; mammary gland development; and positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; early embryo; embryo mesenchyme; genitourinary system; and gut. Orthologous to human HOXB9 (homeobox B9). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription, anterior/posterior pattern specification, cell chemotaxis, embryonic skeletal system development, embryonic skeletal system morphogenesis, mammary gland development, positive regulation of transcription by RNA polymerase II, proximal/distal pattern formation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal system development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, nucleoplasm, nucleus
Pathways:
UniProt: P20615
Entrez ID: 15417
|
Does Knockout of Zcchc18 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Zcchc18
|
phagocytosis
|
macrophage
|
Gene: Zcchc18 (zinc finger, CCHC domain containing 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, zinc ion binding
Pathways:
UniProt: Q8VD24
Entrez ID: 66995
|
Does Knockout of Gpr152 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Gpr152
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gpr152 (G protein-coupled receptor 152)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, identical protein binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q8BXS7
Entrez ID: 269053
|
Does Knockout of Lrtm1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Lrtm1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lrtm1 (leucine-rich repeats and transmembrane domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BXQ3
Entrez ID: 319476
|
Does Knockout of Rpl34 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Rpl34
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rpl34 (ribosomal protein L34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, mitochondrion, nucleolus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D1R9
Entrez ID: 68436
|
Does Knockout of Flcn in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Flcn
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Flcn (folliculin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, TORC1 signaling, cell-cell junction assembly, cellular response to amino acid starvation, cellular response to nutrient levels, cellular response to starvation, energy homeostasis, hemopoiesis, in utero embryonic development, intracellular signal transduction, lysosome localization, lysosome organization, negative regulation of DNA-templated transcription, negative regulation of ERK1 and ERK2 cascade, negative regulation of Rho protein signal transduction, negative regulation of TOR signaling, negative regulation of brown fat cell differentiation, negative regulation of cell population proliferation, negative regulation of cell proliferation involved in kidney development, negative regulation of cold-induced thermogenesis, negative regulation of epithelial cell proliferation, negative regulation of glycolytic process, negative regulation of intracellular signal transduction, negative regulation of lysosome organization, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of post-translational protein modification, negative regulation of protein localization to nucleus, negative regulation of transcription by RNA polymerase II, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of transforming growth factor beta receptor signaling pathway, protein destabilization, regulation of Ras protein signal transduction, regulation of TOR signaling, regulation of pro-B cell differentiation; MF: GTPase activator activity, enzyme binding, enzyme inhibitor activity, protein binding, protein-containing complex binding; CC: FNIP-folliculin RagC/D GAP, cell projection, cell-cell contact zone, centrosome, cilium, cytoplasm, cytoskeleton, cytosol, lysosomal membrane, lysosome, membrane, midbody, mitotic spindle, nucleus, plasma membrane, spindle
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Renal cell carcinoma - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q8QZS3
Entrez ID: 216805
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