prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Fpr-rs6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Fpr-rs6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fpr-rs6 (formyl peptide receptor, related sequence 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, complement receptor mediated signaling pathway, inflammatory response, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, signal transduction; MF: G protein-coupled receptor activity, N-formyl peptide receptor activity, complement receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Formyl peptide receptors bind formyl peptides and many other ligands, G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: Q3SXG2
Entrez ID: 321020
|
Does Knockout of Rictor in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rictor
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rictor (RPTOR independent companion of MTOR, complex 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TOR signaling, TORC2 signaling, actin cytoskeleton organization, cGAS/STING signaling pathway, cellular response to nutrient levels, cytoskeleton organization, embryo development ending in birth or egg hatching, lipid biosynthetic process, negative regulation of apoptotic process, negative regulation of cGAS/STING signaling pathway, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of TOR signaling, positive regulation of actin filament polymerization, positive regulation of cell growth, positive regulation of cell migration, positive regulation of endothelial cell proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of actin cytoskeleton organization, regulation of establishment of cell polarity, regulation of gene expression, regulation of inflammatory response, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of protein phosphorylation; MF: ATP binding, enzyme-substrate adaptor activity, metal ion binding, molecular adaptor activity, nucleotide binding, protein binding, protein kinase binding, protein serine/threonine kinase activator activity, ribosome binding, zinc ion binding; CC: TORC2 complex, endoplasmic reticulum, endoplasmic reticulum membrane, lysosomal membrane, lysosome, membrane, plasma membrane, serine/threonine protein kinase complex
Pathways: Adaptive Immune System, CD28 dependent PI3K/Akt signaling, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Co-stimulation by CD28, Gene expression (Transcription), Generic Transcription Pathway, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Immune System, Intracellular signaling by second messengers, PIP3 activates AKT signaling, RNA Polymerase II Transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Response of endothelial cells to shear stress, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Transcriptional Regulation by TP53, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q6QI06
Entrez ID: 78757
|
Does Knockout of Ndufs8 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Ndufs8
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ndufs8 (NADH:ubiquinone oxidoreductase core subunit S8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: 4 iron, 4 sulfur cluster binding, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q8K3J1
Entrez ID: 225887
|
Does Knockout of Syt17 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Syt17
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Syt17 (synaptotagmin XVII)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, positive regulation of dendrite extension, regulation of calcium ion-dependent exocytosis, regulation of postsynaptic neurotransmitter receptor internalization, vesicle-mediated transport; MF: SNARE binding, calcium ion sensor activity, calcium-dependent phospholipid binding; CC: exocytic vesicle, glutamatergic synapse, membrane, plasma membrane, postsynapse, trans-Golgi network
Pathways:
UniProt: Q920M7
Entrez ID: 110058
|
Does Knockout of Vps36 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Vps36
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vps36 (vacuolar protein sorting 36)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosomal transport, endosome transport via multivesicular body sorting pathway, protein transport, protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; MF: lipid binding, phosphatidylinositol-3-phosphate binding, ubiquitin binding; CC: ESCRT II complex, cytoplasm, cytosol, endosome, late endosome, late endosome membrane, lysosome, membrane, nucleus
Pathways: Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), Membrane Trafficking, Vesicle-mediated transport
UniProt: Q91XD6
Entrez ID: 70160
|
Does Knockout of Rfpl4b in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rfpl4b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rfpl4b (ret finger protein-like 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, zinc ion binding
Pathways:
UniProt: J3QPR6
Entrez ID: 215919
|
Does Knockout of Nuak1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Nuak1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nuak1 (NUAK family, SNF1-like kinase, 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cell adhesion, protein phosphorylation, regulation of cell adhesion, regulation of cellular senescence; MF: ATP binding, kinase activity, nucleotide binding, p53 binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, fibrillar center, microtubule cytoskeleton, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q641K5
Entrez ID: 77976
|
Does Knockout of Tecr in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 1
| 1,522
|
Knockout
|
Tecr
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Tecr (trans-2,3-enoyl-CoA reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid elongation, fatty acid metabolic process, lipid metabolic process, sphingolipid metabolic process, steroid biosynthetic process, very long-chain fatty acid biosynthetic process; MF: oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, very-long-chain enoyl-CoA reductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs
UniProt: Q9CY27
Entrez ID: 106529
|
Does Knockout of Rab5c in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Rab5c
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rab5c (RAB5C, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytosis, endosomal transport, endosome organization, intracellular protein transport, plasma membrane to endosome transport, protein transport, regulation of endocytosis; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: early endosome, early endosome membrane, endocytic vesicle, endomembrane system, endosome, lipid droplet, melanosome, membrane, plasma membrane, synaptic vesicle membrane
Pathways: Amoebiasis - Mus musculus (mouse), Clathrin-mediated endocytosis, Endocytosis - Mus musculus (mouse), Golgi Associated Vesicle Biogenesis, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Phagosome - Mus musculus (mouse), Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Ras signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Vasopressin-regulated water reabsorption - Mus musculus (mouse), Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: P35278
Entrez ID: 19345
|
Does Knockout of Mpv17l2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mpv17l2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mpv17l2 (MPV17 mitochondrial membrane protein-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial ribosome assembly, positive regulation of mitochondrial translation; MF: mitochondrial large ribosomal subunit binding, molecular_function; CC: cytoplasm, membrane, mitochondrial inner membrane, mitochondrion
Pathways: Peroxisome - Mus musculus (mouse)
UniProt: Q8VIK2
Entrez ID: 234384
|
Does Knockout of Rbm12 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Rbm12
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rbm12 (RNA binding motif protein 12)
Type: protein-coding
Summary: This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 2 H2. Two alternatively spliced transcript variants have been identified for this gene. Both variants encode the same protein. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: nucleoplasm, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q8R4X3
Entrez ID: 75710
|
Does Knockout of Sfxn1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Sfxn1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sfxn1 (sideroflexin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alanine transport, L-serine transport, amino acid transport, erythrocyte differentiation, iron ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, one-carbon metabolic process, serine import into mitochondrion, transmembrane transport; MF: L-alanine transmembrane transporter activity, L-serine transmembrane transporter activity, monoatomic ion transmembrane transporter activity, transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q99JR1
Entrez ID: 14057
|
Does Knockout of Gm3500 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gm3500
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gm3500 (predicted gene 3500)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0AA74KT55, A6NAS7
Entrez ID: 100041678
|
Does Knockout of Ercc5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Ercc5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ercc5 (excision repair cross-complementing rodent repair deficiency, complementation group 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, UV protection, base-excision repair, AP site formation, determination of adult lifespan, double-strand break repair via homologous recombination, multicellular organism growth, negative regulation of apoptotic process, nucleotide-excision repair, response to UV, response to UV-C, transcription-coupled nucleotide-excision repair; MF: DNA binding, DNA endonuclease activity, RNA polymerase II complex binding, bubble DNA binding, catalytic activity, damaged DNA binding, double-stranded DNA binding, endonuclease activity, enzyme activator activity, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding, nuclease activity, protein homodimerization activity, protein-containing complex binding, single-stranded DNA binding; CC: DNA replication factor A complex, chromosome, nucleotide-excision repair complex, nucleus, protein-containing complex
Pathways: Nucleotide excision repair - Mus musculus (mouse)
UniProt: Q3UV64, E9QM61
Entrez ID: 22592
|
Does Knockout of Pin4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Pin4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pin4 (peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing; MF: DNA binding, bent DNA binding, double-stranded DNA binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity; CC: chromosome, cytoplasm, cytoskeleton, mitochondrial matrix, nucleolus, nucleoplasm, nucleus, preribosome, spindle
Pathways:
UniProt: Q9CWW6
Entrez ID: 69713
|
Does Knockout of Dph6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Dph6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dph6 (diphthamine biosynthesis 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein histidyl modification to diphthamide; MF: ATP binding, diphthine-ammonia ligase activity, ligase activity, nucleotide binding
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Synthesis of diphthamide-EEF2
UniProt: Q9CQ28
Entrez ID: 66632
|
Does Knockout of Chd6 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Chd6
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Chd6 (chromodomain helicase DNA binding protein 6)
Type: protein-coding
Summary: This gene encodes a member of the chromodomain/helicase/DNA-binding domain family of chromatin remodeling enzymes. This protein has been found to be specifically involved in transcription initiation and elongation. Homozygous knockout mice exhibit impaired motor coordination. A pseudogene has been identified on chromosome 8. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: cell redox homeostasis, chromatin organization, chromatin remodeling, positive regulation of transcription by RNA polymerase II, regulation of gene expression; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent chromatin remodeler activity, DNA binding, chromatin binding, histone binding, hydrolase activity, nucleotide binding, transcription coregulator binding; CC: chromatin, nucleoplasm, nucleus
Pathways:
UniProt: A3KFM7
Entrez ID: 71389
|
Does Knockout of Ccrl2 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Ccrl2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Ccrl2 (C-C motif chemokine receptor-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium-mediated signaling, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, immune response, inflammatory response, positive regulation of cytosolic calcium ion concentration, signal transduction; MF: C-C chemokine binding, C-C chemokine receptor activity, CCR chemokine receptor binding, G protein-coupled receptor activity, chemokine receptor activity, chemokine receptor binding; CC: cytoplasm, external side of plasma membrane, membrane, plasma membrane
Pathways: Chemokine receptors bind chemokines, Class A/1 (Rhodopsin-like receptors), GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: O35457
Entrez ID: 54199
|
Does Knockout of Tex2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Tex2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tex2 (testis expressed gene 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lipid transport; MF: lipid binding, molecular_function; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nucleus
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6ZPJ0
Entrez ID: 21763
|
Does Knockout of Cd200r3 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Cd200r3
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Cd200r3 (CD200 receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse)
UniProt: Q5UKY4
Entrez ID: 74603
|
Does Knockout of Thoc6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Thoc6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Thoc6 (THO complex 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic process, central nervous system development, mRNA export from nucleus, mRNA processing, mRNA transport; MF: RNA binding, protein binding; CC: THO complex, THO complex part of transcription export complex, chromosome, telomeric region, nuclear body, nuclear speck, nucleoplasm, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q5U4D9
Entrez ID: 386612
|
Does Knockout of Kif27 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Kif27
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kif27 (kinesin family member 27)
Type: protein-coding
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in cilium assembly. Acts upstream of or within epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; and ventricular system development. Located in cilium. Is expressed in several structures, including choroid plexus; floor plate; genitourinary system; liver; and spleen. Used to study hydrocephalus. Orthologous to human KIF27 (kinesin family member 27). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell projection organization, cilium assembly, epithelial cilium movement involved in extracellular fluid movement, establishment of localization in cell, microtubule-based movement, ventricular system development; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, nucleotide binding, protein binding; CC: cell projection, cilium, cytoplasm, cytoskeleton, extracellular region, kinesin complex, microtubule
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q7M6Z4
Entrez ID: 75050
|
Does Knockout of Tex28 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Tex28
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tex28 (testis expressed 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endomembrane system, membrane
Pathways:
UniProt: B1AYN9
Entrez ID: 385380
|
Does Knockout of Pds5a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Pds5a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pds5a (PDS5 cohesin associated factor A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, cell division, embryonic skeletal system morphogenesis, enteric nervous system development, heart morphogenesis, lens development in camera-type eye, metanephros development, mitotic sister chromatid cohesion, negative regulation of DNA replication, neuroblast migration, roof of mouth development; CC: chromatin, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: A0A0J9YV33, E9QPI5
Entrez ID: 71521
|
Does Knockout of Nutf2-ps1 in macrophage causally result in phagocytosis?
| 1
| 1,888
|
Knockout
|
Nutf2-ps1
|
phagocytosis
|
macrophage
|
Gene: Nutf2-ps1 (nuclear transport factor 2, pseudogene 1)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100043462
|
Does Knockout of Pold3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Pold3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pold3 (polymerase (DNA-directed), delta 3, accessory subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA synthesis involved in UV-damage excision repair, DNA-templated DNA replication, error-prone translesion synthesis, nucleotide-excision repair, DNA gap filling; MF: DNA-directed DNA polymerase activity, protein-macromolecule adaptor activity; CC: cytoplasm, delta DNA polymerase complex, nucleoplasm, nucleus, zeta DNA polymerase complex
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9EQ28
Entrez ID: 67967
|
Does Knockout of Zc3hc1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Zc3hc1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zc3hc1 (zinc finger, C3HC type 1)
Type: protein-coding
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in cell division and protein ubiquitination. Located in nucleus. Orthologous to human ZC3HC1 (zinc finger C3HC-type containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, protein ubiquitination; MF: metal ion binding, protein kinase binding, zinc ion binding; CC: nuclear envelope, nuclear membrane, nuclear pore nuclear basket, nucleoplasm, nucleus
Pathways:
UniProt: Q80YV2
Entrez ID: 232679
|
Does Knockout of Pramel1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Pramel1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pramel1 (PRAME like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, acrosomal vesicle, cell projection, cilium, cytoplasm, cytoplasmic vesicle, motile cilium
Pathways:
UniProt: Q99MW3
Entrez ID: 83491
|
Does Knockout of Unk in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Unk
|
cell cycle progression
|
breast epithelium
|
Gene: Unk (unkempt family zinc finger)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell morphogenesis involved in neuron differentiation, in utero embryonic development, negative regulation of cytoplasmic translation, neuron migration, regulation of translation; MF: RNA binding, mRNA CDS binding, metal ion binding, ribosome binding, zinc ion binding; CC: cytoplasm
Pathways:
UniProt: Q8BL48
Entrez ID: 217331
|
Does Knockout of Uimc1 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,558
|
Knockout
|
Uimc1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Uimc1 (ubiquitin interaction motif containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, chromatin organization, double-strand break repair, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, negative regulation of DNA-templated transcription, positive regulation of DNA repair, regulation of DNA repair, response to ionizing radiation; MF: DNA binding, K63-linked polyubiquitin modification-dependent protein binding, histone binding, metal ion binding, nuclear retinoid X receptor binding, ubiquitin-modified histone reader activity, zinc ion binding; CC: BRCA1-A complex, nuclear body, nucleoplasm, nucleus, site of double-strand break
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, G2/M DNA damage checkpoint, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Processing of DNA double-strand break ends, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q5U5Q9
Entrez ID: 20184
|
Does Knockout of Ccdc149 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Ccdc149
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Ccdc149 (coiled-coil domain containing 149)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A0G2JF66, F6V035, A0A1D5RM99
Entrez ID: 100503884
|
Does Knockout of Ercc2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ercc2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, UV protection, apoptotic process, bone mineralization, central nervous system myelin formation, chromosome segregation, determination of adult lifespan, embryonic cleavage, embryonic organ development, erythrocyte maturation, extracellular matrix organization, hair cell differentiation, hair cycle process, hair follicle maturation, hematopoietic stem cell differentiation, hematopoietic stem cell proliferation, in utero embryonic development, insulin-like growth factor receptor signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), multicellular organism growth, nucleobase-containing compound metabolic process, nucleotide-excision repair, positive regulation of mitotic recombination, post-embryonic development, regulation of mitotic cell cycle phase transition, regulation of transcription by RNA polymerase II, response to UV, response to hypoxia, response to oxidative stress, ribosomal small subunit biogenesis, skin development, spinal cord development, transcription by RNA polymerase II, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase II promoter, transcription-coupled nucleotide-excision repair; MF: 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, damaged DNA binding, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, iron-sulfur cluster binding, isomerase activity, metal ion binding, nucleic acid binding, nucleotide binding, protein-macromolecule adaptor activity; CC: CAK-ERCC2 complex, MMXD complex, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, spindle, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Mus musculus (mouse), DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, mRNA Capping
UniProt: O08811
Entrez ID: 13871
|
Does Knockout of Gjb3 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gjb3
|
phagocytosis
|
macrophage
|
Gene: Gjb3 (gap junction protein, beta 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell communication, cell-cell signaling, placenta development, transmembrane transport; MF: gap junction channel activity, protein binding; CC: anchoring junction, cell junction, cell-cell junction, connexin complex, cytoplasm, gap junction, membrane, plasma membrane
Pathways: Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Vesicle-mediated transport
UniProt: P28231
Entrez ID: 14620
|
Does Knockout of Znhit2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Znhit2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Znhit2 (zinc finger, HIT domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, zinc ion binding
Pathways:
UniProt: Q9QY66
Entrez ID: 29805
|
Does Knockout of Rps10 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Rps10
|
response to virus
|
Microglial Cell Line
|
Gene: Rps10 (ribosomal protein S10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, ribosomal small subunit assembly, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome, tRNA binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P63325
Entrez ID: 67097
|
Does Knockout of Clpp in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Clpp
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Clpp (caseinolytic mitochondrial matrix peptidase proteolytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: membrane protein proteolysis, protein quality control for misfolded or incompletely synthesized proteins, proteolysis, proteolysis involved in protein catabolic process; MF: ATP-dependent peptidase activity, ATPase binding, endopeptidase activity, hydrolase activity, identical protein binding, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: endopeptidase Clp complex, mitochondrial matrix, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial protein degradation
UniProt: O88696
Entrez ID: 53895
|
Does Knockout of Mlh3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,278
|
Knockout
|
Mlh3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mlh3 (mutL homolog 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, female meiosis I, intracellular protein localization, male meiotic nuclear division, mismatch repair, synaptonemal complex assembly; MF: ATP binding, ATP hydrolysis activity, ATP-dependent DNA damage sensor activity, centromeric DNA binding, chromatin binding, mismatched DNA binding; CC: chiasma, condensed chromosome, condensed nuclear chromosome, male germ cell nucleus, mismatch repair complex, nucleoplasm, synaptonemal complex
Pathways: Mismatch repair - Mus musculus (mouse)
UniProt: A0A1Y7VMP7, Q68FG1, Q3V1X3, Q8BZC3, A0A1Y7VJX4
Entrez ID: 217716
|
Does Knockout of Prelid3a in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Prelid3a
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Prelid3a (PRELI domain containing 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermembrane lipid transfer, lipid transport, phospholipid transport; MF: phosphatidic acid transfer activity; CC: mitochondrial intermembrane space, mitochondrion
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53
UniProt: Q8VE85
Entrez ID: 225655
|
Does Knockout of Zfp446 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Zfp446
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zfp446 (zinc finger protein 446)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q8C9M8, Q149D4, G3X9U2, E9Q6F9
Entrez ID: 269870
|
Does Knockout of Fbxo40 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Fbxo40
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fbxo40 (F-box protein 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, muscle cell differentiation; MF: metal ion binding, molecular_function, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: P62932
Entrez ID: 207215
|
Does Knockout of Arf6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Arf6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Arf6 (ARF GTPase 6)
Type: protein-coding
Summary: Predicted to enable several functions, including G protein activity; guanyl ribonucleotide binding activity; and thioesterase binding activity. Involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of protein localization. Acts upstream of or within several processes, including erythrocyte apoptotic process; hepatocyte apoptotic process; and liver development. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ARF6 (ARF GTPase 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, cell division, cellular response to nerve growth factor stimulus, cortical actin cytoskeleton organization, endocytic recycling, erythrocyte apoptotic process, establishment of epithelial cell polarity, hepatocyte apoptotic process, intracellular protein transport, liver development, maintenance of postsynaptic density structure, negative regulation of dendrite development, negative regulation of protein localization to cell surface, nervous system development, positive regulation of actin filament polymerization, positive regulation of focal adhesion disassembly, positive regulation of keratinocyte migration, positive regulation of mitotic cytokinetic process, positive regulation of neuron projection development, positive regulation of protein localization to plasma membrane, positive regulation of protein secretion, protein localization to cell surface, protein localization to cleavage furrow, protein localization to endosome, protein localization to plasma membrane, protein transport, regulation of Rac protein signal transduction, regulation of dendritic spine development, regulation of filopodium assembly, regulation of neuron projection development, regulation of presynapse assembly, regulation of toll-like receptor 4 signaling pathway, ruffle assembly, synaptic vesicle endocytosis, vesicle-mediated transport; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding, signaling adaptor activity, thioesterase binding; CC: Flemming body, Golgi apparatus, cell cortex, cell projection, cleavage furrow, cytoplasm, cytosol, early endosome, early endosome membrane, endocytic vesicle, endosome, endosome membrane, filopodium membrane, glutamatergic synapse, membrane, midbody, myelin sheath, plasma membrane, postsynapse, presynapse, recycling endosome, recycling endosome membrane, ruffle
Pathways: Clathrin-mediated endocytosis, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), MET receptor recycling, Membrane Trafficking, Phospholipase D signaling pathway - Mus musculus (mouse), Rab regulation of trafficking, Ras signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases, TBC/RABGAPs, Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: P62331
Entrez ID: 11845
|
Does Knockout of Rbm17 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,549
|
Knockout
|
Rbm17
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rbm17 (RNA binding motif protein 17)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Located in nucleus. Part of protein-containing complex. Is expressed in brain; cerebral cortex; hippocampus; ovary; and primary sex cord. Orthologous to human RBM17 (RNA binding motif protein 17). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, alternative mRNA splicing, via spliceosome, mRNA cis splicing, via spliceosome, mRNA processing; MF: RNA binding, nucleic acid binding, protein binding; CC: nucleoplasm, nucleus, protein-containing complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8JZX4
Entrez ID: 76938
|
Does Knockout of Eif4a3 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Eif4a3
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Eif4a3 (eukaryotic translation initiation factor 4A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, embryonic cranial skeleton morphogenesis, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, negative regulation of excitatory postsynaptic potential, negative regulation of gene expression, negative regulation of selenocysteine incorporation, negative regulation of translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of mRNA splicing, via spliceosome, positive regulation of transcription by RNA polymerase II, positive regulation of translation, rRNA processing, regulation of alternative mRNA splicing, via spliceosome, regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translation, regulation of translation at postsynapse, modulating synaptic transmission; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA stem-loop binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, poly(A) binding, ribonucleoprotein complex binding, selenocysteine insertion sequence binding; CC: U2-type catalytic step 1 spliceosome, catalytic step 2 spliceosome, cytoplasm, dendrite, exon-exon junction complex, glutamatergic synapse, neuronal cell body, nuclear speck, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), ISG15 antiviral mechanism, Immune System, Interferon Signaling, Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q91VC3
Entrez ID: 192170
|
Does Knockout of Ndrg4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Ndrg4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ndrg4 (N-myc downstream regulated gene 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration involved in heart development, negative regulation of platelet-derived growth factor receptor signaling pathway, negative regulation of smooth muscle cell migration, negative regulation of smooth muscle cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of neuron projection development, regulation of endocytic recycling, signal transduction, vesicle docking, visual learning; CC: basolateral plasma membrane, cell projection membrane, cytoplasm, cytosol, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q8BTG7
Entrez ID: 234593
|
Does Knockout of Hdac5 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Hdac5
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Hdac5 (histone deacetylase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell differentiation, cellular response to fluid shear stress, chromatin organization, epigenetic regulation of gene expression, heart development, inflammatory response, multicellular organismal response to stress, negative regulation of DNA-templated transcription, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of gene expression, negative regulation of myotube differentiation, negative regulation of osteoblast differentiation, negative regulation of striated muscle tissue development, negative regulation of transcription by RNA polymerase II, nervous system development, osteoblast development, positive regulation of neural precursor cell proliferation, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of myotube differentiation, regulation of skeletal muscle fiber development, regulation of skeletal muscle fiber differentiation, renal tubule morphogenesis, response to cocaine, response to xenobiotic stimulus; MF: DNA-binding transcription activator activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, histone deacetylase activity, histone deacetylase activity, hydrolytic mechanism, histone deacetylase binding, hydrolase activity, identical protein binding, metal ion binding, protein binding, protein kinase C binding, protein kinase binding, protein lysine deacetylase activity, transcription cis-regulatory region binding, transcription corepressor activity, transcription corepressor binding; CC: Golgi apparatus, RNA polymerase II transcription repressor complex, axonal growth cone, chromatin, cytoplasm, cytosol, histone deacetylase complex, nuclear body, nuclear speck, nucleus, protein-containing complex
Pathways: Alcoholism - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q6P9T4, Q3UJF1, B7ZDF5, B7ZDF7, A2AWS5, D6RH93, B7ZDF3, B7ZDF6, B7ZDF4
Entrez ID: 15184
|
Does Knockout of Rab7 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Rab7
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rab7 (RAB7, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, bone resorption, early endosome to late endosome transport, endosome to lysosome transport, endosome to plasma membrane protein transport, epidermal growth factor catabolic process, establishment of vesicle localization, intracellular protein transport, lipid catabolic process, lipid metabolic process, lipophagy, negative regulation of exosomal secretion, neurotransmitter receptor transport, postsynaptic endosome to lysosome, phagosome acidification, phagosome-lysosome fusion, positive regulation of exosomal secretion, positive regulation of protein catabolic process, positive regulation of viral process, protein localization to lysosome, protein targeting to lysosome, protein to membrane docking, protein transport, response to bacterium, retrograde transport, endosome to Golgi, synaptic vesicle recycling via endosome, vesicle-mediated transport in synapse, viral release from host cell; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding, retromer complex binding, small GTPase binding; CC: Golgi apparatus, alveolar lamellar body, autophagosome membrane, bounding membrane of organelle, cytoplasm, cytoplasmic vesicle, cytosol, endosome, endosome membrane, glutamatergic synapse, late endosome, late endosome membrane, lipid droplet, lysosomal membrane, lysosome, melanosome membrane, membrane, mitochondrial membrane, mitochondrion, phagocytic vesicle, phagocytic vesicle membrane, phagophore assembly site membrane, presynaptic endosome, retromer complex, synaptic vesicle membrane
Pathways: Adaptive Immune System, Amoebiasis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Immune System, Innate Immune System, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitophagy - animal - Mus musculus (mouse), Neutrophil degranulation, Phagosome - Mus musculus (mouse), Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, RHOH GTPase cycle, RHOQ GTPase cycle, Rab regulation of trafficking, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TBC/RABGAPs, Tuberculosis - Mus musculus (mouse), Vesicle-mediated transport
UniProt: P51150
Entrez ID: 19349
|
Does Knockout of Cyp2c70 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Cyp2c70
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cyp2c70 (cytochrome P450, family 2, subfamily c, polypeptide 70)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epoxygenase P450 pathway, xenobiotic catabolic process; MF: heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q91W64
Entrez ID: 226105
|
Does Knockout of Ddx49 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Ddx49
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ddx49 (DEAD box helicase 49)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in positive regulation of cell growth; rRNA processing; and regulation of rRNA stability. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DDX49 (DEAD-box helicase 49). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: positive regulation of cell growth, rRNA processing, regulation of rRNA stability; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q4FZF3
Entrez ID: 234374
|
Does Knockout of Dtl in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,287
|
Knockout
|
Dtl
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dtl (denticleless E3 ubiquitin protein ligase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA replication, mitotic G2 DNA damage checkpoint signaling, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of catabolic process, positive regulation of protein catabolic process, positive regulation of protein metabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of cell cycle, response to UV, rhythmic process, translesion synthesis, ubiquitin-dependent protein catabolic process; MF: protein-macromolecule adaptor activity, ubiquitin-protein transferase activity; CC: Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, centrosome, chromosome, cytoplasm, cytoskeleton, cytosol, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Repair, Metabolism of proteins, Neddylation, Post-translational protein modification, Recognition of DNA damage by PCNA-containing replication complex
UniProt: Q3TLR7
Entrez ID: 76843
|
Does Knockout of Arglu1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Arglu1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Arglu1 (arginine and glutamate rich 1)
Type: protein-coding
Summary: Enables pre-mRNA binding activity and transcription coactivator activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and leg muscle. Orthologous to human ARGLU1 (arginine and glutamate rich 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing, positive regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, pre-mRNA binding, transcription coactivator activity; CC: chromosome, cytosol, mitochondrion, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q3UL36
Entrez ID: 234023
|
Does Knockout of Hbp1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Hbp1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Hbp1 (high mobility group box transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of lipid transport, negative regulation of macrophage derived foam cell differentiation, negative regulation of reactive oxygen species biosynthetic process, negative regulation of transcription by RNA polymerase II, positive regulation of potassium ion transport, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding; CC: nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q8R316
Entrez ID: 73389
|
Does Knockout of Ccdc93 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Ccdc93
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccdc93 (coiled-coil domain containing 93)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, endocytic recycling, protein transport; CC: early endosome, endosome
Pathways:
UniProt: Q7TQK5
Entrez ID: 70829
|
Does Knockout of Slc30a3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Slc30a3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Slc30a3 (solute carrier family 30 (zinc transporter), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detoxification of zinc ion, monoatomic cation transport, monoatomic ion transport, positive regulation of transport, response to zinc ion, transmembrane transport, zinc ion import into lysosome, zinc ion import into synaptic vesicle, zinc ion transmembrane transport, zinc ion transport; MF: antiporter activity, metal ion binding, monoatomic cation transmembrane transporter activity, zinc ion transmembrane transporter activity; CC: cytoplasm, cytoplasmic vesicle, endosome, glutamatergic synapse, hippocampal mossy fiber, hippocampal mossy fiber to CA3 synapse, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, microvesicle, neuron projection, plasma membrane, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways:
UniProt: P97441
Entrez ID: 22784
|
Does Knockout of B4galnt4 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
B4galnt4
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: B4galnt4 (beta-1,4-N-acetyl-galactosaminyl transferase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity, acetylgalactosaminyltransferase activity, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, membrane
Pathways: Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q766D5
Entrez ID: 330671
|
Does Knockout of Vnn1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Vnn1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Vnn1 (vanin 1)
Type: protein-coding
Summary: Enables pantetheine hydrolase activity. Involved in several processes, including coenzyme A catabolic process; positive regulation of T cell differentiation in thymus; and positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; facial bone primordium; genitourinary system; nervous system; and respiratory system. Orthologous to human VNN1 (vanin 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: acute inflammatory response, cell-cell adhesion, chronic inflammatory response, coenzyme A catabolic process, inflammatory response, innate immune response, pantothenate metabolic process, positive regulation of T cell differentiation in thymus, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; MF: GPI anchor binding, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, pantetheine hydrolase activity; CC: extracellular space, membrane, plasma membrane, side of membrane
Pathways: Immune System, Innate Immune System, Metabolism, Metabolism of proteins, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Neutrophil degranulation, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Vitamin B5 (pantothenate) metabolism
UniProt: Q9Z0K8
Entrez ID: 22361
|
Does Knockout of Atp6v1e1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Atp6v1e1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Atp6v1e1 (ATPase, H+ transporting, lysosomal V1 subunit E1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, endosome, extrinsic component of synaptic vesicle membrane, membrane, microvillus, mitochondrion, plasma membrane, proton-transporting two-sector ATPase complex, catalytic domain, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: P50518
Entrez ID: 11973
|
Does Knockout of Cybb in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Cybb
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cybb (cytochrome b-245, beta polypeptide)
Type: protein-coding
Summary: This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013].
Gene Ontology: BP: cellular response to L-glutamine, cellular response to cadmium ion, cellular response to ethanol, cellular response to hypoxia, defense response, hydrogen peroxide biosynthetic process, hypoxia-inducible factor-1alpha signaling pathway, inflammatory response, innate immune response, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of angiogenesis, positive regulation of tumor necrosis factor production, respiratory burst, response to aldosterone, response to angiotensin, response to ethanol, response to nutrient, response to xenobiotic stimulus, superoxide anion generation, superoxide metabolic process; MF: FAD binding, NAD(P)H oxidase H2O2-forming activity, NADPH binding, electron transfer activity, flavin adenine dinucleotide binding, heme binding, metal ion binding, oxidoreductase activity, protein binding, protein heterodimerization activity, superoxide-generating NAD(P)H oxidase activity, superoxide-generating NADPH oxidase activity, voltage-gated proton channel activity; CC: NADPH oxidase complex, cytoplasm, dendrite, membrane, mitochondrion, monoatomic ion channel complex, neuronal cell body, nuclear envelope, perinuclear endoplasmic reticulum, phagocytic vesicle, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adaptive Immune System, Alzheimer disease - Mus musculus (mouse), Antigen processing-Cross presentation, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Cross-presentation of particulate exogenous antigens (phagosomes), Detoxification of Reactive Oxygen Species, Diabetic cardiomyopathy - Mus musculus (mouse), Ferroptosis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Leishmaniasis - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Neutrophil degranulation, Neutrophil extracellular trap formation - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate NADPH Oxidases, ROS and RNS production in phagocytes, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: Q61093
Entrez ID: 13058
|
Does Knockout of Bcl3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Bcl3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Bcl3 (B cell leukemia/lymphoma 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, T-helper 1 type immune response, T-helper 2 cell differentiation, antimicrobial humoral response, apoptotic process, canonical NF-kappaB signal transduction, defense response to bacterium, defense response to protozoan, extracellular matrix organization, follicular dendritic cell differentiation, germinal center formation, humoral immune response mediated by circulating immunoglobulin, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, marginal zone B cell differentiation, negative regulation of DNA-templated transcription, negative regulation of T cell apoptotic process, negative regulation of apoptotic process, negative regulation of cytokine production, negative regulation of interleukin-8 production, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of tumor necrosis factor production, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of interleukin-10 production, positive regulation of transcription by RNA polymerase II, positive regulation of translation, positive regulation of type II interferon production, protein import into nucleus, regulation of apoptotic process, regulation of non-canonical NF-kappaB signal transduction, response to UV-C, response to other organism, response to stress, response to virus, spleen development; MF: DNA-binding transcription factor binding, histone deacetylase binding, protein binding, protein-macromolecule adaptor activity, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity; CC: Bcl3-Bcl10 complex, Bcl3/NF-kappaB2 complex, ciliary basal body, cytoplasm, cytosol, midbody, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: Q9Z2F6
Entrez ID: 12051
|
Does Knockout of Mir6420 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Mir6420
|
cell cycle progression
|
breast epithelium
|
Gene: Mir6420 (microRNA 6420)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465228
|
Does Knockout of Emc3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Emc3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Emc3 (ER membrane protein complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein insertion into ER membrane by stop-transfer membrane-anchor sequence, tail-anchored membrane protein insertion into ER membrane; MF: membrane insertase activity; CC: EMC complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q99KI3
Entrez ID: 66087
|
Does Knockout of Cd47 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Cd47
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cd47 (CD47 antigen (Rh-related antigen, integrin-associated signal transducer))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP export, angiogenesis, apoptotic process, cell adhesion, cell migration, cell-cell adhesion, cellular response to interleukin-1, cellular response to interleukin-12, cellular response to type II interferon, inflammatory response, monocyte aggregation, negative regulation of phagocytosis, opsonization, positive regulation of T cell activation, positive regulation of activation-induced cell death of T cells, positive regulation of cell population proliferation, positive regulation of cell-cell adhesion, positive regulation of immune system process, positive regulation of inflammatory response, positive regulation of monocyte extravasation, positive regulation of phagocytosis, positive regulation of stress fiber assembly, regulation of Fc receptor mediated stimulatory signaling pathway, regulation of interleukin-10 production, regulation of interleukin-12 production, regulation of interleukin-6 production, regulation of nitric oxide biosynthetic process, regulation of synapse pruning, regulation of tumor necrosis factor production, regulation of type II interferon production, response to bacterium; MF: cell-cell adhesion mediator activity, fibrinogen binding, protein binding, protein binding involved in heterotypic cell-cell adhesion, thrombospondin receptor activity; CC: cell surface, extracellular exosome, glutamatergic synapse, membrane, plasma membrane, presynapse
Pathways: Cell surface interactions at the vascular wall, Cell-Cell communication, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Hemostasis, Immune System, Innate Immune System, Integrin cell surface interactions, Neutrophil degranulation, Signal regulatory protein family interactions
UniProt: Q61735
Entrez ID: 16423
|
Does Knockout of Ptgis in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Ptgis
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ptgis (prostaglandin I2 (prostacyclin) synthase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic signaling pathway, cellular response to hypoxia, cellular response to interleukin-1, cellular response to interleukin-6, cyclooxygenase pathway, decidualization, embryo implantation, fatty acid biosynthetic process, fatty acid metabolic process, icosanoid metabolic process, lipid metabolic process, negative regulation of cell population proliferation, negative regulation of inflammatory response, negative regulation of nitric oxide biosynthetic process, negative regulation of smooth muscle cell proliferation, positive regulation of angiogenesis, positive regulation of execution phase of apoptosis, positive regulation of gene expression, positive regulation of peroxisome proliferator activated receptor signaling pathway, prostaglandin biosynthetic process, prostaglandin metabolic process, response to hypoxia; MF: heme binding, hydroperoxy icosatetraenoate dehydratase activity, iron ion binding, isomerase activity, lyase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, prostaglandin-I synthase activity; CC: caveola, cytoplasm, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, Fatty acid metabolism, Metabolism, Metabolism of lipids, Phase I - Functionalization of compounds, Synthesis of Prostaglandins (PG) and Thromboxanes (TX), biosynthesis of prostaglandins
UniProt: O35074
Entrez ID: 19223
|
Does Knockout of Bsg in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Bsg
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Bsg (basigin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, axon guidance, cell differentiation, decidualization, dendrite self-avoidance, embryo implantation, endothelial tube morphogenesis, homophilic cell adhesion via plasma membrane adhesion molecules, neural retina development, neuron projection extension, neutrophil chemotaxis, odontogenesis of dentin-containing tooth, photoreceptor cell maintenance, positive regulation of endothelial cell migration, positive regulation of interleukin-6 production, positive regulation of matrix metallopeptidase secretion, positive regulation of vascular endothelial growth factor production, positive regulation of viral entry into host cell, protein localization to plasma membrane, response to cAMP, response to mercury ion, response to peptide hormone, spermatogenesis; MF: D-mannose binding, carbohydrate binding, cell-cell adhesion mediator activity, protein binding, signaling receptor activity, virus receptor activity; CC: acrosomal membrane, axon, basolateral plasma membrane, cell projection, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, membrane, photoreceptor inner segment, photoreceptor outer segment, plasma membrane, sarcolemma
Pathways: Aspirin ADME, Basigin interactions, Cell surface interactions at the vascular wall, Degradation of the extracellular matrix, Drug ADME, Extracellular matrix organization, Hemostasis, Integrin cell surface interactions, Proton-coupled monocarboxylate transport, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: P18572
Entrez ID: 12215
|
Does Knockout of Adamts2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Adamts2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Adamts2 (ADAM metallopeptidase with thrombospondin type 1 motif 2)
Type: protein-coding
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: collagen catabolic process, collagen fibril organization, extracellular matrix organization, lung development, protein processing, proteolysis, skin development, spermatogenesis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular matrix, extracellular region
Pathways: Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization, Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8C9W3
Entrez ID: 216725
|
Does Knockout of Il13ra1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Il13ra1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Il13ra1 (interleukin 13 receptor, alpha 1)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that complexes with interleukin 4 receptor alpha (IL4RA) to form a functional receptor for interleukin-13. Signalling through this pathway mediates allergy response and occurs during bronchial asthma. [provided by RefSeq, May 2015].
Gene Ontology: BP: cytokine-mediated signaling pathway, positive regulation of immunoglobulin production; MF: cytokine binding, cytokine receptor activity, interleukin-13 receptor activity; CC: external side of plasma membrane, membrane, receptor complex
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-4 and Interleukin-13 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signaling by Interleukins
UniProt: O09030
Entrez ID: 16164
|
Does Knockout of Pim1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Pim1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pim1 (proviral integration site 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular detoxification, cellular response to amino acid starvation, cellular response to nutrient levels, cellular response to type II interferon, cytolysis in another organism, defense response to bacterium, negative regulation of TORC1 signaling, negative regulation of apoptotic process, negative regulation of innate immune response, non-canonical inflammasome complex assembly, positive regulation of DNA-templated transcription, positive regulation of TORC1 signaling, positive regulation of brown fat cell differentiation, positive regulation of cardiac muscle cell proliferation, positive regulation of cardioblast proliferation, protein phosphorylation, protein stabilization, regulation of hematopoietic stem cell proliferation, regulation of mitotic cell cycle, regulation of transmembrane transporter activity, vitamin D receptor signaling pathway; MF: ATP binding, kinase activity, manganese ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, ribosomal small subunit binding, transferase activity; CC: cytoplasm, cytosol, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: P06803
Entrez ID: 18712
|
Does Knockout of Isg20 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Isg20
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Isg20 (interferon-stimulated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA catabolic process, RNA catabolic process, RNA processing, defense response to virus, immune system process, innate immune response, negative regulation of viral genome replication, rRNA processing, response to virus; MF: 3'-5'-RNA exonuclease activity, RNA binding, U1 snRNA binding, U2 snRNA binding, U3 snoRNA binding, exonuclease activity, exoribonuclease II activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, single-stranded DNA 3'-5' DNA exonuclease activity; CC: Cajal body, P-body, PML body, cytoplasm, nucleolus, nucleus
Pathways:
UniProt: Q9JL16
Entrez ID: 57444
|
Does Knockout of Cela3a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Cela3a
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cela3a (chymotrypsin-like elastase family, member 3A)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Orthologous to several human genes including CELA3B (chymotrypsin like elastase 3B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity
Pathways: Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: A2A9U8
Entrez ID: 242711
|
Does Knockout of Ccr4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Ccr4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccr4 (C-C motif chemokine receptor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium-mediated signaling, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, homeostasis of number of cells, immune response, inflammatory response, interneuron migration, neuron migration, positive regulation of cytosolic calcium ion concentration, positive regulation of positive chemotaxis, signal transduction, tolerance induction; MF: C-C chemokine binding, C-C chemokine receptor activity, G protein-coupled receptor activity, chemokine receptor activity; CC: external side of plasma membrane, membrane, neuronal cell body, plasma membrane
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral carcinogenesis - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P51680
Entrez ID: 12773
|
Does Knockout of Acp6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Acp6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Acp6 (acid phosphatase 6, lysophosphatidic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hematopoietic progenitor cell differentiation, lipid metabolic process, lysobisphosphatidic acid metabolic process, phospholipid metabolic process; MF: acid phosphatase activity, hydrolase activity, lysophosphatidic acid phosphatase activity; CC: cytoplasm, mitochondrion
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, NAD phosphorylation and dephosphorylation, NAD salvage pathway II, Phospholipid metabolism, Synthesis of PA, phosphate acquisition, phosphate acquisition II
UniProt: Q8BP40
Entrez ID: 66659
|
Does Knockout of Vmn1r104 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Vmn1r104
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vmn1r104 (vomeronasal 1 receptor 104)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: L7N293
Entrez ID: 667135
|
Does Knockout of Kif11 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Kif11
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Kif11 (kinesin family member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule-based movement, mitotic centrosome separation, mitotic nuclear division, mitotic spindle assembly, regulation of mitotic centrosome separation, spindle assembly, spindle elongation, spindle organization; MF: ATP binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein kinase binding; CC: ciliary basal body, cytoplasm, cytoskeleton, cytosol, microtubule, mitotic spindle, nucleus, protein-containing complex, spindle, spindle microtubule, spindle pole
Pathways: Adaptive Immune System, COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q6P9P6
Entrez ID: 16551
|
Does Knockout of Syk in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Syk
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Syk (spleen tyrosine kinase)
Type: protein-coding
Summary: Enables several functions, including ATP binding activity; SH2 domain binding activity; and enzyme binding activity. Involved in several processes, including cell surface receptor signaling pathway; myeloid cell activation involved in immune response; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including positive regulation of lymphocyte activation; positive regulation of macromolecule metabolic process; and protein phosphorylation. Located in early phagosome. Part of B cell receptor complex. Is expressed in liver and notochord. Human ortholog(s) of this gene implicated in immunodeficiency 82. Orthologous to human SYK (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell receptor signaling pathway, G protein-coupled receptor signaling pathway, TORC1 signaling, adaptive immune response, amyloid-beta clearance, angiogenesis, antigen receptor-mediated signaling pathway, apoptotic signaling pathway, autophagosome assembly, beta selection, blood vessel morphogenesis, cell activation, cell surface pattern recognition receptor signaling pathway, cell surface receptor signaling pathway, cellular response to amyloid-beta, cellular response to lectin, cellular response to lipid, cellular response to low-density lipoprotein particle stimulus, cellular response to molecule of fungal origin, cellular response to nutrient levels, collagen-activated tyrosine kinase receptor signaling pathway, defense response to bacterium, enzyme-linked receptor protein signaling pathway, establishment of localization in cell, immune system process, innate immune response, integrin-mediated signaling pathway, interleukin-3-mediated signaling pathway, intracellular signal transduction, leukocyte activation involved in immune response, leukocyte cell-cell adhesion, leukotriene biosynthetic process, lymph vessel development, macrophage activation involved in immune response, negative regulation of TORC1 signaling, negative regulation of autophagy, neutrophil activation involved in immune response, neutrophil chemotaxis, peptidyl-tyrosine phosphorylation, positive regulation of B cell differentiation, positive regulation of MAPK cascade, positive regulation of TORC1 signaling, positive regulation of alpha-beta T cell differentiation, positive regulation of alpha-beta T cell proliferation, positive regulation of autophagy, positive regulation of bone resorption, positive regulation of calcium-mediated signaling, positive regulation of cell adhesion mediated by integrin, positive regulation of cold-induced thermogenesis, positive regulation of cytokine production, positive regulation of gamma-delta T cell differentiation, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-3 production, positive regulation of interleukin-4 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of mast cell cytokine production, positive regulation of mast cell degranulation, positive regulation of monocyte chemotactic protein-1 production, positive regulation of protein-containing complex assembly, positive regulation of receptor internalization, positive regulation of superoxide anion generation, positive regulation of tumor necrosis factor production, positive regulation of type I interferon production, protein import into nucleus, receptor internalization, regulation of ERK1 and ERK2 cascade, regulation of arachidonate secretion, regulation of immune response, regulation of neutrophil degranulation, regulation of phagocytosis, regulation of platelet activation, regulation of platelet aggregation, regulation of superoxide anion generation, regulation of tumor necrosis factor-mediated signaling pathway, serotonin secretion, serotonin secretion by platelet, stimulatory C-type lectin receptor signaling pathway; MF: ATP binding, SH2 domain binding, Toll-like receptor binding, integrin binding, interleukin-15 receptor binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, phosphatase binding, phospholipase binding, phosphotyrosine residue binding, protein binding, protein domain specific binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein tyrosine kinase activity, scaffold protein binding, signaling receptor binding, transferase activity, ubiquitin protein ligase binding; CC: B cell receptor complex, T cell receptor complex, cytoplasm, cytoplasmic vesicle, cytosol, early phagosome, membrane, nucleus, phagocytic vesicle, plasma membrane, protein-containing complex
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, B cell receptor signaling pathway - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, Dectin-2 family, Epstein-Barr virus infection - Mus musculus (mouse), FCERI mediated Ca+2 mobilization, FCERI mediated MAPK activation, FCGR activation, FLT3 Signaling, FLT3 signaling through SRC family kinases, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, GPVI-mediated activation cascade, Hemostasis, Herpes simplex virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of CSF3 (G-CSF) signaling, Innate Immune System, Integrin signaling, Interleukin-2 family signaling, Interleukin-2 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet Aggregation (Plug Formation), Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Regulation of actin dynamics for phagocytic cup formation, Regulation of signaling by CBL, Role of LAT2/NTAL/LAB on calcium mobilization, Role of phospholipids in phagocytosis, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by Interleukins, Signaling by the B Cell Receptor (BCR), Tuberculosis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: P48025
Entrez ID: 20963
|
Does Knockout of Palb2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Palb2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Palb2 (partner and localizer of BRCA2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, animal organ morphogenesis, double-strand break repair via homologous recombination, embryonic organ development, in utero embryonic development, inner cell mass cell proliferation, mesoderm development, multicellular organism growth, negative regulation of apoptotic process, post-anal tail morphogenesis, somitogenesis; MF: DNA binding; CC: DNA repair complex, nuclear speck, nucleoplasm, nucleus, protein-containing complex
Pathways: DNA Double-Strand Break Repair, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q3U0P1
Entrez ID: 233826
|
Does Knockout of Slc47a1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Slc47a1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Slc47a1 (solute carrier family 47, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alpha-amino acid transmembrane transport, L-arginine import across plasma membrane, L-arginine transmembrane transport, amino acid import across plasma membrane, monoatomic cation transmembrane transport, monoatomic cation transport, organic cation transport, proton transmembrane transport, putrescine transport, thiamine transmembrane transport, transmembrane transport, xenobiotic detoxification by transmembrane export across the plasma membrane, xenobiotic transmembrane transport, xenobiotic transport; MF: L-amino acid transmembrane transporter activity, L-arginine transmembrane transporter activity, amide transmembrane transporter activity, antiporter activity, organic cation transmembrane transporter activity, polyspecific organic cation:proton antiporter activity, putrescine transmembrane transporter activity, thiamine transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, plasma membrane, vesicle
Pathways: SLC-mediated transmembrane transport, SLC-mediated transport of organic cations, Transport of small molecules
UniProt: Q8K0H1
Entrez ID: 67473
|
Does Knockout of Vmn1r238 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Vmn1r238
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Vmn1r238 (vomeronasal 1 receptor, 238)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: E9Q373
Entrez ID: 100312476
|
Does Knockout of Mcrs1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Mcrs1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mcrs1 (microspherule protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin organization, chromatin remodeling, negative regulation of telomere maintenance via telomere lengthening, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein localization to nucleolus, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, regulation of telomere maintenance, telomere maintenance; MF: G-quadruplex RNA binding, poly(G) binding, poly(U) RNA binding, telomerase inhibitor activity; CC: Ino80 complex, MLL1 complex, NSL complex, centriolar satellite, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, dendrite, histone acetyltransferase complex, kinetochore, lysosome, nuclear body, nucleolus, nucleoplasm, nucleus, perikaryon, spindle pole
Pathways: Chromatin modifying enzymes, Chromatin organization, DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Global Genome Nucleotide Excision Repair (GG-NER), HATs acetylate histones, Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q99L90
Entrez ID: 51812
|
Does Knockout of Rnaseh2a in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,171
|
Knockout
|
Rnaseh2a
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Rnaseh2a (ribonuclease H2, large subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, removal of RNA primer, RNA catabolic process, RNA metabolic process, mismatch repair; MF: RNA binding, RNA-DNA hybrid ribonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding; CC: cytosol, nucleoplasm, nucleus, ribonuclease H2 complex
Pathways: DNA replication - Mus musculus (mouse)
UniProt: Q9CWY8
Entrez ID: 69724
|
Does Knockout of Tas2r140 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Tas2r140
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Tas2r140 (taste receptor, type 2, member 140)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse)
UniProt: Q7TQA4
Entrez ID: 387616
|
Does Knockout of Rbsn in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Rbsn
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rbsn (rabenosyn, RAB effector)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to lysosome transport, early endosome to Golgi transport, protein transport, regulation of Golgi organization; MF: metal ion binding, phosphatidylinositol-3-phosphate binding, small GTPase binding, zinc ion binding; CC: cytosol, early endosome, early endosome membrane, endosome, membrane, plasma membrane
Pathways: Endocytosis - Mus musculus (mouse), Factors involved in megakaryocyte development and platelet production, Hemostasis, Immune System, Innate Immune System, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades
UniProt: Q80Y56
Entrez ID: 78287
|
Does Knockout of Psma6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Psma6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Psma6 (proteasome subunit alpha 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of canonical NF-kappaB signal transduction, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, regulation of inflammatory response, skeletal muscle tissue development, ubiquitin-dependent protein catabolic process; MF: NF-kappaB binding, RNA binding, protein binding; CC: P-body, cilium, cytoplasm, cytosol, mitochondrion, myofibril, nuclear matrix, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, ribosome, sarcomere
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9QUM9
Entrez ID: 26443
|
Does Knockout of Pak4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Pak4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pak4 (p21 (RAC1) activated kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to starvation, dendritic spine development, intracellular signal transduction, negative regulation of endothelial cell apoptotic process, positive regulation of angiogenesis, positive regulation of focal adhesion disassembly, protein stabilization, regulation of MAPK cascade; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-macromolecule adaptor activity, transferase activity; CC: cytoplasm
Pathways: Axon guidance - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOG GTPase cycle, RHOH GTPase cycle, RHOQ GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, T cell receptor signaling pathway - Mus musculus (mouse)
UniProt: Q8BTW9
Entrez ID: 70584
|
Does Knockout of Sec23a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Sec23a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Sec23a (SEC23 homolog A, COPII coat complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII-coated vesicle budding, COPII-coated vesicle cargo loading, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein localization to plasma membrane, protein transport, vesicle-mediated transport; MF: GTPase activator activity, metal ion binding, protein binding, zinc ion binding; CC: COPII vesicle coat, COPII-coated ER to Golgi transport vesicle, ER to Golgi transport vesicle membrane, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, membrane, perinuclear region of cytoplasm
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, Class I MHC mediated antigen processing & presentation, ER to Golgi Anterograde Transport, Immune System, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q01405
Entrez ID: 20334
|
Does Knockout of Esf1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Esf1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Esf1 (ESF1 nucleolar pre-rRNA processing protein homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q3V1V3
Entrez ID: 66580
|
Does Knockout of C2cd3 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
C2cd3
|
protein/peptide accumulation
|
Mouse cell
|
Gene: C2cd3 (C2 calcium-dependent domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cell projection organization, centriole elongation, cilium assembly, embryonic digit morphogenesis, embryonic limb morphogenesis, heart looping, in utero embryonic development, neural plate axis specification, neural tube development, non-motile cilium assembly, pattern specification process, protein localization to centrosome, protein processing, regulation of proteolysis, regulation of smoothened signaling pathway; CC: cell projection, centriolar satellite, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule organizing center
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q52KB6
Entrez ID: 277939
|
Does Knockout of Smad6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Smad6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Smad6 (SMAD family member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, SMAD protein signal transduction, anatomical structure morphogenesis, aorta development, aortic valve morphogenesis, cardiac vascular smooth muscle cell development, cell differentiation, cell-substrate adhesion, coronary vasculature development, coronary vasculature morphogenesis, fat cell differentiation, heart valve development, immune response, mitral valve morphogenesis, negative regulation of BMP signaling pathway, negative regulation of SMAD protein signal transduction, negative regulation of activin receptor signaling pathway, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of ossification, negative regulation of osteoblast differentiation, negative regulation of transforming growth factor beta receptor signaling pathway, outflow tract septum morphogenesis, positive regulation of miRNA transcription, positive regulation of vasoconstriction, pulmonary valve morphogenesis, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to estrogen, response to laminar fluid shear stress, response to lipopolysaccharide, ureteric bud development, vasoconstriction, ventricular septum development, zygotic specification of dorsal/ventral axis; MF: I-SMAD binding, R-SMAD binding, chromatin binding, co-SMAD binding, identical protein binding, metal ion binding, protein binding, protein sequestering activity, transcription cis-regulatory region binding, transcription regulator inhibitor activity, type I activin receptor binding, type I transforming growth factor beta receptor binding, ubiquitin protein ligase binding; CC: Golgi apparatus, ciliary basal body, cilium, cytoplasm, cytosol, heteromeric SMAD protein complex, nuclear body, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: Signal Transduction, Signaling by BMP, Signaling by TGFB family members, TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: O35182
Entrez ID: 17130
|
Does Knockout of Csrnp2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Csrnp2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Csrnp2 (cysteine-serine-rich nuclear protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, phosphatase binding, sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q8BGQ2
Entrez ID: 207785
|
Does Knockout of Ints13 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,287
|
Knockout
|
Ints13
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ints13 (integrator complex subunit 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, cell division, centrosome localization, flagellated sperm motility, mitotic spindle organization, protein localization to nuclear envelope, regulation of fertilization, regulation of mitotic cell cycle, snRNA processing; MF: DNA-binding transcription factor binding, molecular_function; CC: INTAC complex, cytoplasm, integrator complex, nuclear body, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q8QZV7
Entrez ID: 71177
|
Does Knockout of Txnrd1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Txnrd1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Txnrd1 (thioredoxin reductase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, May 2017].
Gene Ontology: BP: benzene-containing compound metabolic process, cell population proliferation, cell redox homeostasis, cellular oxidant detoxification, gastrulation, hydrogen peroxide catabolic process, mesoderm formation, positive regulation of apoptotic process, response to oxidative stress, selenocysteine metabolic process; MF: FAD binding, NAD(P)H oxidase H2O2-forming activity, NADPH peroxidase activity, flavin adenine dinucleotide binding, identical protein binding, mercury ion binding, oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor, selenate reductase activity, thioredoxin-disulfide reductase (NADPH) activity; CC: cytoplasm, cytosol, fibrillar center, mitochondrion, neuronal cell body, nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of amino acids and derivatives, Metabolism of ingested MeSeO2H into MeSeH, Metabolism of nucleotides, Pathways in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Selenoamino acid metabolism, Selenocompound metabolism - Mus musculus (mouse), TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, thioredoxin pathway
UniProt: Q9JMH6
Entrez ID: 50493
|
Does Knockout of Cdca3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Cdca3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cdca3 (cell division cycle associated 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, protein ubiquitination; CC: adherens junction, cytoplasm, cytosol
Pathways:
UniProt: Q99M54
Entrez ID: 14793
|
Does Knockout of Gpc1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Gpc1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gpc1 (glypican 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell differentiation, cell migration, heparan sulfate proteoglycan catabolic process, myelin assembly, negative regulation of fibroblast growth factor receptor signaling pathway, positive regulation of skeletal muscle cell differentiation, regulation of protein localization to membrane, regulation of signal transduction; MF: collagen V binding, copper ion binding, fibroblast growth factor binding, laminin binding; CC: Golgi lumen, cell surface, cytosol, endosome, extracellular matrix, extracellular region, membrane, membrane raft, neuronal cell body, nucleoplasm, plasma membrane, side of membrane, synapse
Pathways: Axon guidance, Cell surface interactions at the vascular wall, Developmental Biology, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glycosaminoglycan metabolism, Glycosaminoglycan-protein linkage region biosynthesis, HS-GAG biosynthesis, HS-GAG degradation, Hemostasis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Nervous system development, Proteoglycans in cancer - Mus musculus (mouse), Retinoid metabolism and transport, Sensory Perception, Signaling by ROBO receptors, Visual phototransduction
UniProt: Q9QZF2
Entrez ID: 14733
|
Does Knockout of Traf6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Traf6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Traf6 (TNF receptor-associated factor 6)
Type: protein-coding
Summary: This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: CD40 signaling pathway, DNA damage response, JNK cascade, T cell receptor signaling pathway, T-helper 1 type immune response, animal organ morphogenesis, antigen processing and presentation of exogenous peptide antigen via MHC class II, antiviral innate immune response, autophagosome assembly, bone remodeling, bone resorption, canonical NF-kappaB signal transduction, cell development, cellular response to cytokine stimulus, cellular response to lipopolysaccharide, cellular response to oxygen-containing compound, cytokine-mediated signaling pathway, cytoplasmic pattern recognition receptor signaling pathway, defense response to bacterium, immune response, immune system process, in utero embryonic development, innate immune response, interleukin-1-mediated signaling pathway, interleukin-17-mediated signaling pathway, interleukin-17A-mediated signaling pathway, interleukin-33-mediated signaling pathway, intracellular signaling cassette, lipopolysaccharide-mediated signaling pathway, mRNA transcription, myeloid dendritic cell differentiation, negative regulation of DNA-templated transcription, negative regulation of canonical NF-kappaB signal transduction, negative regulation of transcription by RNA polymerase II, neural tube closure, non-canonical NF-kappaB signal transduction, odontogenesis of dentin-containing tooth, ossification, osteoclast differentiation, positive regulation of JNK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell cytokine production, positive regulation of T cell proliferation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of interleukin-12 production, positive regulation of interleukin-2 production, positive regulation of interleukin-6 production, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of lipopolysaccharide-mediated signaling pathway, positive regulation of osteoclast differentiation, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of type I interferon production, protein K48-linked ubiquitination, protein K63-linked ubiquitination, protein autoubiquitination, protein branched polyubiquitination, protein polyubiquitination, protein ubiquitination, regulation of apoptotic process, regulation of canonical NF-kappaB signal transduction, regulation of immunoglobulin production, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, regulation protein catabolic process at postsynapse, response to interleukin-1, signal transduction, synapse assembly, toll-like receptor 4 signaling pathway, tumor necrosis factor-mediated signaling pathway; MF: histone deacetylase binding, identical protein binding, metal ion binding, protein binding, protein kinase B binding, protein-macromolecule adaptor activity, signaling adaptor activity, transferase activity, tumor necrosis factor receptor binding, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, zinc ion binding; CC: CD40 receptor complex, cell cortex, cytoplasm, cytoplasmic side of plasma membrane, cytosol, glutamatergic synapse, lipid droplet, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynapse, protein-containing complex
Pathways: Alcoholic liver disease - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: P70196
Entrez ID: 22034
|
Does Knockout of Mus81 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,545
|
Knockout
|
Mus81
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Mus81 (MUS81 structure-specific endonuclease subunit)
Type: protein-coding
Summary: Predicted to enable 3'-flap endonuclease activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process; mitotic intra-S DNA damage checkpoint signaling; and osteoblast proliferation. Predicted to act upstream of or within DNA catabolic process and response to intra-S DNA damage checkpoint signaling. Predicted to be located in nuclear replication fork. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus and replication fork. Used to study Marfan syndrome; arterial tortuosity syndrome; and pulmonary emphysema. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA catabolic process, DNA damage response, DNA recombination, DNA repair, double-strand break repair, double-strand break repair via break-induced replication, mitotic intra-S DNA damage checkpoint signaling, osteoblast proliferation, replication fork processing, resolution of meiotic recombination intermediates, resolution of mitotic recombination intermediates, response to intra-S DNA damage checkpoint signaling, telomere maintenance; MF: 3'-flap endonuclease activity, DNA binding, DNA endonuclease activity, DNA endonuclease activity, producing 3'-phosphomonoesters, crossover junction DNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity; CC: Holliday junction resolvase complex, chromosome, telomeric region, endodeoxyribonuclease complex, nuclear replication fork, nucleolus, nucleus, replication fork
Pathways: DNA Double-Strand Break Repair, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q91ZJ0
Entrez ID: 71711
|
Does Knockout of B230217C12Rik in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
B230217C12Rik
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: B230217C12Rik (RIKEN cDNA B230217C12 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q3Z1, A0A1B0GR59
Entrez ID: 68127
|
Does Knockout of Polr1b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Polr1b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Polr1b (polymerase (RNA) I polypeptide B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, embryo implantation, neural crest formation, nucleologenesis, rRNA transcription; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, DNA/RNA hybrid binding, metal ion binding, nucleotidyltransferase activity, protein binding, ribonucleoside binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, chromosome, cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Mus musculus (mouse)
UniProt: P70700
Entrez ID: 20017
|
Does Knockout of Topors in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Topors
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Topors (topoisomerase I binding, arginine/serine-rich)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, maintenance of protein location in nucleus, positive regulation of DNA-templated transcription, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein localization to nucleus, protein monoubiquitination, protein polyubiquitination, protein sumoylation, regulation of cell population proliferation, ubiquitin-dependent protein catabolic process; MF: DNA binding, DNA topoisomerase binding, SUMO transferase activity, antigen binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: PML body, centriole, ciliary basal body, gamma-tubulin complex, nuclear speck, nucleoplasm, nucleus, photoreceptor connecting cilium, spindle pole, ubiquitin ligase complex
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of SUMOylation proteins, SUMOylation of immune response proteins, SUMOylation of transcription cofactors
UniProt: Q80Z37
Entrez ID: 106021
|
Does Knockout of Sspo in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Sspo
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Sspo (SCO-spondin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell adhesion; MF: extracellular matrix structural constituent, molecular_function; CC: cytoplasm, extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: A0A087WRI0, E9Q0I4, A0A087WNT4, A0A1D5RLZ9
Entrez ID: 243369
|
Does Knockout of Dimt1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Dimt1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Dimt1 (DIM1 rRNA methyltransferase and ribosome maturation factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, positive regulation of rRNA processing, rRNA methylation, rRNA modification, rRNA processing, ribosomal small subunit biogenesis; MF: 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity, RNA binding, methyltransferase activity, rRNA (adenine-N6,N6-)-dimethyltransferase activity, transferase activity; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways:
UniProt: Q9D0D4
Entrez ID: 66254
|
Does Knockout of Ube2m in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Ube2m
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ube2m (ubiquitin-conjugating enzyme E2M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of neuron apoptotic process, protein modification process, protein neddylation, regulation of postsynapse assembly; MF: ATP binding, NEDD8 conjugating enzyme activity, NEDD8 transferase activity, nucleotide binding, transferase activity, ubiquitin-protein transferase activity; CC: cytosol, glutamatergic synapse, nucleus, postsynapse, presynapse
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Immune System, Innate Immune System, Metabolism of proteins, NIK-->noncanonical NF-kB signaling, Neddylation, Post-translational protein modification, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, TNFR2 non-canonical NF-kB pathway, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P61082
Entrez ID: 22192
|
Does Knockout of Ak6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Ak6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ak6 (adenylate kinase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleoside monophosphate phosphorylation, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: AMP kinase activity, ATP binding, ATP hydrolysis activity, kinase activity, nucleotide binding, transferase activity; CC: Cajal body, centrosome, cytoplasm, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways: Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Mus musculus (mouse), Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q8VCP8
Entrez ID: 102216272
|
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