prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Clip2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Clip2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Clip2 (CAP-GLY domain containing linker protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: microtubule binding, microtubule plus-end binding, protein binding; CC: cell cortex, cytoplasm, cytoplasmic microtubule, cytoskeleton, dendritic microtubule, lamellar body, microtubule, microtubule cytoskeleton, microtubule plus-end, nucleus
Pathways:
UniProt: Q9Z0H8
Entrez ID: 269713
|
Does Knockout of Mterf2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Mterf2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mterf2 (mitochondrial transcription termination factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, nucleic acid binding; CC: mitochondrial matrix, mitochondrial nucleoid, mitochondrion
Pathways:
UniProt: Q8BKY8
Entrez ID: 74238
|
Does Knockout of Pik3c3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Pik3c3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pik3c3 (phosphatidylinositol 3-kinase catalytic subunit type 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagosome maturation, autophagy, cell division, cellular response to glucose starvation, cellular response to starvation, early endosome to late endosome transport, endocytosis, endosome organization, host-mediated activation of viral genome replication, interleukin-6-mediated signaling pathway, lipid metabolic process, macroautophagy, pexophagy, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, positive regulation of natural killer cell mediated cytotoxicity, protein localization to phagophore assembly site, protein processing, protein targeting to lysosome, regulation of autophagy, regulation of cytokinesis, regulation of macroautophagy, response to L-leucine, synaptic vesicle endocytosis, type II interferon-mediated signaling pathway; MF: 1-phosphatidylinositol-3-kinase activity, ATP binding, kinase activity, nucleotide binding, phosphatidylinositol kinase activity, phosphotransferase activity, alcohol group as acceptor, protein binding, protein kinase activity, transferase activity; CC: GABA-ergic synapse, autolysosome, autophagosome, cytoplasm, cytoplasmic vesicle, endosome, glutamatergic synapse, late endosome, membrane, midbody, peroxisome, phagocytic vesicle, phagophore assembly site, phosphatidylinositol 3-kinase complex, class III, phosphatidylinositol 3-kinase complex, class III, type I, phosphatidylinositol 3-kinase complex, class III, type II, plasma membrane, postsynapse, postsynaptic endosome, presynaptic endosome
Pathways: 3-phosphoinositide biosynthesis, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Innate Immune System, Inositol phosphate metabolism - Mus musculus (mouse), Insulin receptor signalling cascade, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Macroautophagy, Metabolism, Metabolism of lipids, PI Metabolism, PI3K Cascade, PIP metabolism, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Spinocerebellar ataxia - Mus musculus (mouse), Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Tuberculosis - Mus musculus (mouse)
UniProt: Q6PF93
Entrez ID: 225326
|
Does Knockout of Lap3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Lap3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lap3 (leucine aminopeptidase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: aminopeptidase activity, carboxypeptidase activity, hydrolase activity, manganese ion binding, metal ion binding, metalloaminopeptidase activity, peptidase activity; CC: cytoplasm, mitochondrion, trans-Golgi network
Pathways: Arginine and proline metabolism - Mus musculus (mouse), Glutathione metabolism - Mus musculus (mouse)
UniProt: Q9CPY7
Entrez ID: 66988
|
Does Knockout of Med24 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Med24
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Med24 (mediator complex subunit 24)
Type: protein-coding
Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, somatic stem cell population maintenance, transcription by RNA polymerase II; MF: histone acetyltransferase activity, nuclear thyroid hormone receptor binding, protein-containing complex binding, transcription coactivator activity, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: Q99K74
Entrez ID: 23989
|
Does Knockout of AA986860 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
AA986860
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: AA986860 (expressed sequence AA986860)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, plasma membrane
Pathways:
UniProt: Q8BI29
Entrez ID: 212439
|
Does Knockout of Ttll5 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Ttll5
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Ttll5 (tubulin tyrosine ligase-like family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fertilization, flagellated sperm motility, retina development in camera-type eye, sperm axoneme assembly, spermatogenesis; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, protein-glutamic acid ligase activity, elongating, protein-glutamic acid ligase activity, initiating, tubulin binding, tubulin-glutamic acid ligase activity; CC: 9+0 non-motile cilium, cell projection, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, microtubule, nucleus, plasma membrane
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: Q8CHB8
Entrez ID: 320244
|
Does Knockout of Rabif in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Rabif
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rabif (RAB interacting factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: post-Golgi vesicle-mediated transport, protein transport, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, metal ion binding, zinc ion binding; CC: cytosol, membrane
Pathways:
UniProt: Q91X96
Entrez ID: 98710
|
Does Knockout of Lbp in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Lbp
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lbp (lipopolysaccharide binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acute-phase response, cell surface pattern recognition receptor signaling pathway, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, detection of molecule of bacterial origin, immune system process, innate immune response, leukocyte chemotaxis involved in inflammatory response, lipid transport, lipopolysaccharide transport, lipopolysaccharide-mediated signaling pathway, macrophage activation involved in immune response, negative regulation of tumor necrosis factor production, opsonization, positive regulation of chemokine production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of macrophage activation, positive regulation of neutrophil chemotaxis, positive regulation of phagocytosis, engulfment, positive regulation of respiratory burst involved in inflammatory response, positive regulation of toll-like receptor 4 signaling pathway, positive regulation of tumor necrosis factor production, regulation of membrane permeability, response to lipopolysaccharide; MF: coreceptor activity, lipid binding, lipopeptide binding, lipopolysaccharide binding, lipoteichoic acid binding, signaling receptor binding; CC: cell surface, extracellular region, extracellular space, membrane
Pathways: Alcoholic liver disease - Mus musculus (mouse), Immune System, Innate Immune System, Lipid and atherosclerosis - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), Regulation of TLR by endogenous ligand, Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Transfer of LPS from LBP carrier to CD14, Tuberculosis - Mus musculus (mouse)
UniProt: Q61805
Entrez ID: 16803
|
Does Knockout of Tmie in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Tmie
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tmie (transmembrane inner ear)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inner ear morphogenesis, sensory perception of sound; CC: membrane, plasma membrane
Pathways:
UniProt: Q8K467
Entrez ID: 20776
|
Does Knockout of Vps18 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Vps18
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vps18 (VPS18 CORVET/HOPS core subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, endosome organization, endosome to lysosome transport, intracellular protein transport, lysosome organization, negative regulation of intracellular estrogen receptor signaling pathway, organelle fusion, protein transport, protein ubiquitination, regulation of synaptic vesicle exocytosis, symbiont entry into host cell, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: actin binding, metal ion binding, protein binding, protein-macromolecule adaptor activity, syntaxin binding, ubiquitin protein ligase activity, zinc ion binding; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, actin filament, autophagosome, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endomembrane system, endosome, glutamatergic synapse, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, presynapse
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q8R307
Entrez ID: 228545
|
Does Knockout of Prepl in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Prepl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prepl (prolyl endopeptidase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, proteolysis, regulation of synaptic vesicle exocytosis, retrograde transport, endosome to Golgi; MF: hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: Golgi apparatus, cytoplasm, cytoskeleton, cytosol, nucleus, trans-Golgi network
Pathways:
UniProt: Q8C167
Entrez ID: 213760
|
Does Knockout of Arg1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Arg1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Arg1 (arginase, liver)
Type: protein-coding
Summary: Enables arginase activity. Involved in defense response to protozoan; negative regulation of T-helper 2 cell cytokine production; and negative regulation of activated T cell proliferation. Acts upstream of or within response to nematode. Predicted to be located in extracellular space; mitochondrial outer membrane; and neuronal cell body. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: adaptive immune response, arginine metabolic process, collagen biosynthetic process, defense response to protozoan, immune system process, innate immune response, negative regulation of T cell proliferation, negative regulation of T-helper 2 cell cytokine production, negative regulation of activated T cell proliferation, negative regulation of type II interferon-mediated signaling pathway, positive regulation of endothelial cell proliferation, positive regulation of neutrophil mediated killing of fungus, regulation of L-arginine import across plasma membrane, regulation of cell population proliferation, response to nematode, urea cycle; MF: arginase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines, identical protein binding, manganese ion binding, metal ion binding; CC: cytoplasm, cytosol, extracellular space, neuronal cell body
Pathways: Amoebiasis - Mus musculus (mouse), Arginine and proline metabolism - Mus musculus (mouse), Arginine biosynthesis - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of amino acids and derivatives, Neutrophil degranulation, Urea cycle, arginine degradation I (arginase pathway), arginine degradation VI (arginase 2 pathway), citrulline biosynthesis, superpathway of citrulline metabolism, urea cycle
UniProt: Q61176
Entrez ID: 11846
|
Does Knockout of Aars2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Aars2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Aars2 (alanyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alanyl-tRNA aminoacylation, aminoacyl-tRNA metabolism involved in translational fidelity, cGAS/STING signaling pathway, mitochondrial alanyl-tRNA aminoacylation, negative regulation of cGAS/STING signaling pathway, tRNA aminoacylation, translation; MF: ATP binding, RNA binding, alanine-tRNA ligase activity, aminoacyl-tRNA deacylase activity, aminoacyl-tRNA ligase activity, ligase activity, metal ion binding, nucleic acid binding, nucleotide binding, peptide lactyltransferase (ATP-dependent) activity, tRNA binding, zinc ion binding; CC: cytoplasm, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q14CH7
Entrez ID: 224805
|
Does Knockout of Jak2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 2,141
|
Knockout
|
Jak2
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Jak2 (Janus kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 1 cell differentiation, activation of Janus kinase activity, adaptive immune response, apoptotic signaling pathway, axon regeneration, cell adhesion, cell differentiation, cell surface receptor signaling pathway via JAK-STAT, cellular response to dexamethasone stimulus, cellular response to interleukin-3, cellular response to lipopolysaccharide, cellular response to steroid hormone stimulus, chromatin organization, chromatin remodeling, collagen-activated signaling pathway, cytokine-mediated signaling pathway, defense response to symbiont, enzyme-linked receptor protein signaling pathway, erythrocyte differentiation, erythropoietin-mediated signaling pathway, extrinsic apoptotic signaling pathway, granulocyte-macrophage colony-stimulating factor signaling pathway, growth hormone receptor signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, hormone-mediated signaling pathway, immune response, immune system process, innate immune response, interleukin-12-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-3-mediated signaling pathway, interleukin-5-mediated signaling pathway, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to oxidative stress, lipopolysaccharide-mediated signaling pathway, mammary gland epithelium development, microglial cell activation, modulation of chemical synaptic transmission, myeloid cell differentiation, negative regulation of 3'-UTR-mediated mRNA stabilization, negative regulation of apoptotic process, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell population proliferation, negative regulation of cell-cell adhesion, negative regulation of cytokine production involved in inflammatory response, negative regulation of growth hormone receptor signaling pathway, negative regulation of neuron apoptotic process, nuclear receptor-mediated mineralocorticoid signaling pathway, platelet-derived growth factor receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of MHC class II biosynthetic process, positive regulation of NK T cell proliferation, positive regulation of SMAD protein signal transduction, positive regulation of T cell proliferation, positive regulation of T-helper 17 type immune response, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, positive regulation of cell activation, positive regulation of cell differentiation, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cell-substrate adhesion, positive regulation of cold-induced thermogenesis, positive regulation of cytosolic calcium ion concentration, positive regulation of epithelial cell apoptotic process, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, positive regulation of growth hormone receptor signaling pathway, positive regulation of insulin secretion, positive regulation of interleukin-1 beta production, positive regulation of interleukin-17 production, positive regulation of intracellular signal transduction, positive regulation of leukocyte proliferation, positive regulation of natural killer cell proliferation, positive regulation of nitric oxide biosynthetic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of platelet activation, positive regulation of platelet aggregation, positive regulation of protein import into nucleus, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of vascular associated smooth muscle cell proliferation, post-embryonic hemopoiesis, post-translational protein modification, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autophosphorylation, regulation of T cell activation, regulation of apoptotic process, regulation of inflammatory response, regulation of leukocyte cell-cell adhesion, regulation of nitric oxide biosynthetic process, regulation of postsynapse to nucleus signaling pathway, response to antibiotic, response to granulocyte macrophage colony-stimulating factor, response to hydroperoxide, response to interleukin-12, response to oxidative stress, response to tumor necrosis factor, signal transduction, symbiont-induced defense-related programmed cell death, thrombopoietin-mediated signaling pathway, tumor necrosis factor-mediated signaling pathway, type II interferon-mediated signaling pathway; MF: ATP binding, SH2 domain binding, acetylcholine receptor binding, cytokine receptor binding, growth hormone receptor binding, heme binding, histone H3Y41 kinase activity, histone binding, identical protein binding, insulin receptor substrate binding, interleukin-12 receptor binding, kinase activity, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, peptide hormone receptor binding, phosphatidylinositol 3-kinase binding, protein binding, protein kinase activity, protein kinase binding, protein tyrosine kinase activity, signaling receptor activator activity, signaling receptor binding, transferase activity, type 1 angiotensin receptor binding; CC: caveola, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endomembrane system, euchromatin, extrinsic component of cytoplasmic side of plasma membrane, extrinsic component of plasma membrane, focal adhesion, glutamatergic synapse, granulocyte macrophage colony-stimulating factor receptor complex, interleukin-12 receptor complex, interleukin-23 receptor complex, membrane, membrane raft, nucleoplasm, nucleus, plasma membrane, postsynapse
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Cyclin D associated events in G1, Cytokine Signaling in Immune system, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Erythropoietin activates RAS, Factors involved in megakaryocyte development and platelet production, G1 Phase, Growth hormone receptor signaling, Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), IFNG signaling activates MAPKs, IL-6-type cytokine receptor ligand interactions, Immune System, Inactivation of CSF3 (G-CSF) signaling, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, Interleukin receptor SHC signaling, Interleukin-12 family signaling, Interleukin-12 signaling, Interleukin-2 family signaling, Interleukin-20 family signaling, Interleukin-23 signaling, Interleukin-27 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Interleukin-35 Signalling, Interleukin-4 and Interleukin-13 signaling, Interleukin-6 family signaling, Interleukin-6 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK family signaling cascades, MAPK1 (ERK2) activation, MAPK1/MAPK3 signaling, MAPK3 (ERK1) activation, Mitotic G1 phase and G1/S transition, Necroptosis - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin receptor signaling, Prolactin signaling pathway - Mus musculus (mouse), RAF activation, RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, Regulation of IFNG signaling, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by Erythropoietin, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q62120
Entrez ID: 16452
|
Does Knockout of Rps26 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Rps26
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rps26 (ribosomal protein S26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, negative regulation of RNA splicing, translation, translation at postsynapse, translation at presynapse; MF: mRNA binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, postsynapse, presynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62855
Entrez ID: 27370
|
Does Knockout of Spata1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Spata1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Spata1 (spermatogenesis associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein binding; CC: acrosomal vesicle, cytoplasmic vesicle
Pathways:
UniProt: Q9D5R4
Entrez ID: 70951
|
Does Knockout of Wfdc16 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Wfdc16
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Wfdc16 (WAP four-disulfide core domain 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, innate immune response; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: A2A5H4, Q5DQQ4
Entrez ID: 277345
|
Does Knockout of Sema3e in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Sema3e
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sema3e (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, axon guidance, branching involved in blood vessel morphogenesis, cell differentiation, gonadotrophin-releasing hormone neuronal migration to the hypothalamus, negative chemotaxis, negative regulation of angiogenesis, negative regulation of cell-matrix adhesion, negative regulation of developmental process, negative regulation of multicellular organismal process, negative regulation of neuron apoptotic process, nervous system development, neural crest cell migration, positive regulation of cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of anatomical structure morphogenesis, regulation of cell shape, regulation of multicellular organismal development, semaphorin-plexin signaling pathway, sprouting angiogenesis, synapse organization; MF: chemorepellent activity, neuropilin binding, protein binding, receptor ligand activity, semaphorin receptor binding, signaling receptor binding; CC: extracellular region, extracellular space, plasma membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, Nervous system development, Other semaphorin interactions, Semaphorin interactions
UniProt: P70275
Entrez ID: 20349
|
Does Knockout of Sh3tc1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Sh3tc1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sh3tc1 (SH3 domain and tetratricopeptide repeats 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3TXV8, G3X9F6, Q3UDI4, F6QD49, F6UWL1, F6U4F1
Entrez ID: 231147
|
Does Knockout of Nr1h4 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 1
| 1,522
|
Knockout
|
Nr1h4
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Nr1h4 (nuclear receptor subfamily 1, group H, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, bile acid metabolic process, cell differentiation, cell-cell junction assembly, cellular response to bile acid, cellular response to fatty acid, cellular response to lipopolysaccharide, cellular response to xenobiotic stimulus, cholesterol homeostasis, defense response to bacterium, fatty acid homeostasis, glucose homeostasis, immune system process, inflammatory response, innate immune response, intracellular glucose homeostasis, intracellular receptor signaling pathway, intracellular triglyceride homeostasis, negative regulation of NF-kappaB transcription factor activity, negative regulation of apoptotic process, negative regulation of canonical NF-kappaB signal transduction, negative regulation of collagen biosynthetic process, negative regulation of inflammatory response, negative regulation of interleukin-1 production, negative regulation of interleukin-2 production, negative regulation of interleukin-6 production, negative regulation of macromolecule biosynthetic process, negative regulation of monocyte chemotactic protein-1 production, negative regulation of transcription by RNA polymerase II, negative regulation of triglyceride biosynthetic process, negative regulation of tumor necrosis factor production, negative regulation of tumor necrosis factor-mediated signaling pathway, negative regulation of type II interferon production, negative regulation of very-low-density lipoprotein particle remodeling, nuclear receptor-mediated bile acid signaling pathway, positive regulation of DNA-templated transcription, positive regulation of adipose tissue development, positive regulation of ammonia assimilation cycle, positive regulation of gene expression, positive regulation of glutamate metabolic process, positive regulation of insulin receptor signaling pathway, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of interleukin-17 production, positive regulation of phosphatidic acid biosynthetic process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of carbohydrate metabolic process, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of low-density lipoprotein particle clearance, regulation of transcription by RNA polymerase II, regulation of urea metabolic process, response to lipopolysaccharide, response to norepinephrine, toll-like receptor 9 signaling pathway, triglyceride homeostasis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, bile acid binding, bile acid nuclear receptor activity, chenodeoxycholic acid binding, double-stranded DNA binding, metal ion binding, nuclear receptor activity, nuclear retinoid X receptor binding, peptide binding, protein binding, protein-containing complex binding, sequence-specific DNA binding, transcription cis-regulatory region binding, transcription coregulator binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytosol, euchromatin, nuclear speck, nucleoplasm, nucleus, receptor complex
Pathways: Bile acid and bile salt metabolism, Bile secretion - Mus musculus (mouse), Biological oxidations, Cytochrome P450 - arranged by substrate type, Endogenous sterols, Gene expression (Transcription), Generic Transcription Pathway, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, Nuclear Receptor transcription pathway, Phase I - Functionalization of compounds, Post-translational protein modification, RNA Polymerase II Transcription, Recycling of bile acids and salts, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of intracellular receptors, Synthesis of bile acids and bile salts, Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
UniProt: Q60641
Entrez ID: 20186
|
Does Knockout of Taf1d in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Taf1d
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Taf1d (TATA-box binding protein associated factor, RNA polymerase I, D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of DNA-templated transcription; MF: DNA binding, identical protein binding, molecular_function; CC: RNA polymerase transcription factor SL1 complex, centriolar satellite, cytosol, mitotic spindle, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination
UniProt: Q9D4V4
Entrez ID: 75316
|
Does Knockout of Mrpl32 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Mrpl32
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mrpl32 (mitochondrial ribosomal protein L32)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: metal ion binding, structural constituent of ribosome; CC: cytosol, large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9DCI9
Entrez ID: 75398
|
Does Knockout of Rpl7a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Rpl7a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rpl7a (ribosomal protein L7A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA, ribosome biogenesis, translation at postsynapse, translation at presynapse; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, nucleolus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P12970
Entrez ID: 27176
|
Does Knockout of Aimp1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Aimp1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Aimp1 (aminoacyl tRNA synthetase complex-interacting multifunctional protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, apoptotic process, cell-cell signaling, inflammatory response, leukocyte migration, negative regulation of endothelial cell proliferation, positive regulation of glucagon secretion, signal transduction, translation; MF: GTPase binding, RNA binding, cytokine activity, protein homodimerization activity, tRNA binding; CC: Golgi apparatus, aminoacyl-tRNA synthetase multienzyme complex, cell surface, cytoplasm, cytosol, endoplasmic reticulum, extracellular region, extracellular space, nucleus
Pathways: Developmental Biology, MITF-M-regulated melanocyte development, Transcriptional and post-translational regulation of MITF-M expression and activity
UniProt: P31230
Entrez ID: 13722
|
Does Knockout of Tmem82 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Tmem82
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmem82 (transmembrane protein 82)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8R115
Entrez ID: 213989
|
Does Knockout of Eloc in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Eloc
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Eloc (elongin C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription elongation by RNA polymerase II, protein ubiquitination, target-directed miRNA degradation, transcription initiation at RNA polymerase II promoter, ubiquitin-dependent protein catabolic process; MF: protein binding, protein-containing complex binding, protein-macromolecule adaptor activity, transcription corepressor binding; CC: Cul5-RING ubiquitin ligase complex, VCB complex, cytoplasm, cytosol, elongin complex, nucleus, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, HIF-1 signaling pathway - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of CSF3 (G-CSF) signaling, Metabolism of proteins, Neddylation, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Renal cell carcinoma - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Signaling by CSF3 (G-CSF), TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53, Translation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P83940
Entrez ID: 67923
|
Does Knockout of BC107364 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
BC107364
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: BC107364 (cDNA sequence BC107364)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3KNB6
Entrez ID: 329716
|
Does Knockout of Eif2s1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Eif2s1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: HRI-mediated signaling, PERK-mediated unfolded protein response, cellular response to UV, cellular response to amino acid starvation, cellular response to chemical stress, cellular response to heat, cellular response to oxidative stress, mitochondrial respirasome assembly, mitophagy, negative regulation of translational initiation in response to stress, positive regulation of type B pancreatic cell apoptotic process, regulation of translation, regulation of translation in response to endoplasmic reticulum stress, regulation of translational initiation in response to stress, response to endoplasmic reticulum stress, response to kainic acid, response to manganese-induced endoplasmic reticulum stress, stress granule assembly, translation, translational initiation; MF: RNA binding, nucleic acid binding, protein binding, ribosome binding, translation initiation factor activity; CC: cytoplasm, cytoplasmic stress granule, cytosol, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 2 complex, glial limiting end-foot, mitochondrion, nucleus, synapse, translation initiation ternary complex
Pathways: ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Cap-dependent Translation Initiation, Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Eukaryotic Translation Initiation, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), L13a-mediated translational silencing of Ceruloplasmin expression, Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, Non-alcoholic fatty liver disease - Mus musculus (mouse), PERK regulates gene expression, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Recycling of eIF2:GDP, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation, Transport of small molecules, Unfolded Protein Response (UPR)
UniProt: Q6ZWX6
Entrez ID: 13665
|
Does Knockout of Tex9 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Tex9
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tex9 (testis expressed gene 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, centriolar satellite, cytoplasm, cytoskeleton
Pathways:
UniProt: Q9D845
Entrez ID: 21778
|
Does Knockout of Defb15 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Defb15
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Defb15 (defensin beta 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response, defense response to bacterium, innate immune response; MF: CCR2 chemokine receptor binding, heparin binding, lipopolysaccharide binding; CC: extracellular region, membrane, microvesicle, nucleus
Pathways:
UniProt: Q8R2I5
Entrez ID: 246082
|
Does Knockout of Vmn1r107 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Vmn1r107
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vmn1r107 (vomeronasal 1 receptor 107)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: D3YTY1
Entrez ID: 673977
|
Does Knockout of Nol9 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Nol9
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nol9 (nucleolar protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of 5.8S rRNA, rRNA processing; MF: ATP binding, ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity, ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity, RNA binding, kinase activity, nucleotide binding, polynucleotide 5'-hydroxyl-kinase activity, transferase activity; CC: intermediate filament cytoskeleton, nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q3TZX8
Entrez ID: 74035
|
Does Knockout of Tmem154 in Regulatory T cell causally result in protein/peptide accumulation?
| 1
| 1,482
|
Knockout
|
Tmem154
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Tmem154 (transmembrane protein 154)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8C4Q9
Entrez ID: 320782
|
Does Knockout of Ptpa in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Ptpa
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ptpa (protein phosphatase 2 protein activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitotic spindle organization, positive regulation of apoptotic process; MF: ATP binding, isomerase activity, metal ion binding, nucleotide binding, peptidyl-prolyl cis-trans isomerase activity, phosphatase activator activity, phosphatase binding, phosphoprotein phosphatase activity, protein homodimerization activity, protein phosphatase 2A binding, protein phosphatase regulator activity, protein tyrosine phosphatase activator activity, signaling receptor binding; CC: ATPase complex, calcium channel complex, cytoplasm, nucleoplasm, nucleus, protein phosphatase type 2A complex
Pathways: Diabetic cardiomyopathy - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse)
UniProt: P58389
Entrez ID: 110854
|
Does Knockout of Yme1l1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Yme1l1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Yme1l1 (YME1-like 1 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation, cellular response to starvation, mitochondrial protein catabolic process, mitochondrial protein processing, mitochondrion organization, negative regulation of apoptotic process, neuronal stem cell population maintenance, positive regulation of mitochondrial fusion, protein hexamerization, protein quality control for misfolded or incompletely synthesized proteins, proteolysis, regulation of stem cell division; MF: ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, nucleotide binding, peptidase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, nuclear body
Pathways: Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Mitochondrial calcium ion transport, Processing of SMDT1, Transport of small molecules
UniProt: O88967
Entrez ID: 27377
|
Does Knockout of Hspa13 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Hspa13
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Hspa13 (heat shock protein 70 family, member 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein folding, protein refolding; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, heat shock protein binding, nucleotide binding, protein folding chaperone; CC: cytoplasm, cytosol, endoplasmic reticulum, nucleus, plasma membrane
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: Q8BM72
Entrez ID: 110920
|
Does Knockout of Car5a in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Car5a
|
phagocytosis
|
macrophage
|
Gene: Car5a (carbonic anhydrase 5a, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbonate dehydratase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytoplasm, mitochondrion
Pathways: Metabolism, Nitrogen metabolism - Mus musculus (mouse), Reversible hydration of carbon dioxide
UniProt: P23589
Entrez ID: 12352
|
Does Knockout of Ube2n in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 2,142
|
Knockout
|
Ube2n
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ube2n (ubiquitin-conjugating enzyme E2N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA repair, T cell receptor signaling pathway, TORC1 signaling, antiviral innate immune response, cellular response to nutrient levels, double-strand break repair via homologous recombination, negative regulation of TORC1 signaling, positive regulation of DNA repair, positive regulation of canonical NF-kappaB signal transduction, positive regulation of double-strand break repair, positive regulation of intracellular signal transduction, positive regulation of protein K63-linked ubiquitination, postreplication repair, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked ubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, regulation protein catabolic process at postsynapse, ubiquitin-dependent protein catabolic process; MF: ATP binding, nucleotide binding, protein binding, transferase activity, ubiquitin binding, ubiquitin conjugating enzyme activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activator activity, ubiquitin-protein transferase activity; CC: UBC13-MMS2 complex, cytoplasm, cytosol, glutamatergic synapse, nucleus, postsynapse, protein-containing complex, ubiquitin conjugating enzyme complex, ubiquitin ligase complex
Pathways: Adaptive Immune System, Aggrephagy, Antigen processing: Ubiquitination & Proteasome degradation, Antiviral mechanism by IFN-stimulated genes, Autophagy, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cell Cycle, Cell Cycle Checkpoints, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Downstream TCR signaling, E3 ubiquitin ligases ubiquitinate target proteins, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of Incision Complex in GG-NER, G2/M Checkpoints, G2/M DNA damage checkpoint, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, IKK complex recruitment mediated by RIP1, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, ISG15 antiviral mechanism, Immune System, Innate Immune System, Interferon Signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, MAP kinase activation, Macroautophagy, Metabolism of proteins, Mitophagy, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NOD1/2 Signaling Pathway, Nonhomologous End-Joining (NHEJ), Nucleotide Excision Repair, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, PINK1-PRKN Mediated Mitophagy, Post-translational protein modification, Processing of DNA double-strand break ends, Protein ubiquitination, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Selective autophagy, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TCR signaling, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ubiquitin mediated proteolysis - Mus musculus (mouse), activated TAK1 mediates p38 MAPK activation
UniProt: P61089
Entrez ID: 93765
|
Does Knockout of Tsen54 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Tsen54
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tsen54 (tRNA splicing endonuclease subunit 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA processing, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation, tRNA-type intron splice site recognition and cleavage; CC: nucleolus, nucleus, tRNA-intron endonuclease complex
Pathways:
UniProt: Q8C2A2
Entrez ID: 76265
|
Does Knockout of Hs6st3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Hs6st3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hs6st3 (heparan sulfate 6-O-sulfotransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heparan sulfate proteoglycan biosynthetic process; MF: heparan sulfate 6-sulfotransferase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, membrane
Pathways: Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q9QYK4
Entrez ID: 50787
|
Does Knockout of Ppan in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Ppan
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ppan (peter pan homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, regulation of cell growth by extracellular stimulus; MF: rRNA binding; CC: nucleolus, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q91YU8
Entrez ID: 235036
|
Does Knockout of Heyl in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Heyl
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Heyl (hairy/enhancer-of-split related with YRPW motif-like)
Type: protein-coding
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including heart development; nephron development; and regulation of transcription by RNA polymerase II. Acts upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation; negative regulation of gene expression; and skeletal muscle cell differentiation. Located in cytoplasm. Is expressed in several structures, including cardiovascular system; embryo mesenchyme; inner ear; nervous system; and urinary system. Orthologous to human HEYL (hes related family bHLH transcription factor with YRPW motif like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Notch signaling pathway, anatomical structure formation involved in morphogenesis, anterior/posterior pattern specification, atrioventricular valve morphogenesis, cardiac epithelial to mesenchymal transition, cardiac ventricle morphogenesis, cellular response to BMP stimulus, endocardial cushion morphogenesis, epithelial to mesenchymal transition involved in endocardial cushion formation, glomerulus development, mesenchymal cell development, muscle organ development, negative regulation of DNA-binding transcription factor activity, negative regulation of DNA-templated transcription, negative regulation of androgen receptor signaling pathway, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, outflow tract morphogenesis, peripheral nervous system development, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, proximal tubule development, pulmonary valve morphogenesis, regulation of DNA-templated transcription, regulation of neurogenesis, regulation of neuron differentiation, regulation of transcription by RNA polymerase II, skeletal muscle cell differentiation, striated muscle tissue development, tissue morphogenesis, ventricular septum morphogenesis; MF: AF-1 domain binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein binding, protein dimerization activity, protein homodimerization activity, sequence-specific DNA binding; CC: cytoplasm, nucleoplasm, nucleus, transcription regulator complex
Pathways: Breast cancer - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Notch signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: Q9DBX7
Entrez ID: 56198
|
Does Knockout of Brf1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Brf1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Brf1 (BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, positive regulation of transcription by RNA polymerase III, regulation of mRNA stability, transcription by RNA polymerase III, transcription preinitiation complex assembly; MF: RNA polymerase III general transcription initiation factor activity, RNA polymerase III type 3 promoter sequence-specific DNA binding, TBP-class protein binding, metal ion binding, zinc ion binding; CC: nucleus, transcription factor TFIIIB complex, transcription preinitiation complex
Pathways:
UniProt: G3X8S2
Entrez ID: 72308
|
Does Knockout of Suds3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Suds3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Suds3 (suppressor of defective silencing 3 homolog (S. cerevisiae))
Type: protein-coding
Summary: Enables histone deacetylase binding activity and identical protein binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within blastocyst hatching. Part of Sin3-type complex. Is expressed in early conceptus; ovary; secondary oocyte; and seminiferous cord. Orthologous to human SUDS3 (SDS3 homolog, SIN3A corepressor complex component). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, blastocyst hatching, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of cell migration, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of stem cell population maintenance, regulation of gene expression; MF: enzyme binding, histone deacetylase activity, histone deacetylase binding, identical protein binding, protein binding; CC: Sin3-type complex, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Deubiquitination, HDACs deacetylate histones, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q8BR65
Entrez ID: 71954
|
Does Knockout of Inca1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Inca1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Inca1 (inhibitor of CDK, cyclin A1 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic signaling pathway, negative regulation of cell population proliferation, negative regulation of fibroblast proliferation, positive regulation of apoptotic signaling pathway; MF: cyclin binding, cyclin-dependent protein serine/threonine kinase inhibitor activity, identical protein binding, protein binding, protein kinase inhibitor activity, protein-containing complex binding; CC: cytoplasm, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q6PKN7
Entrez ID: 103844
|
Does Knockout of Prrt3 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Prrt3
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Prrt3 (proline-rich transmembrane protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q6PE13
Entrez ID: 210673
|
Does Knockout of Cntd1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Cntd1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cntd1 (cyclin N-terminal domain containing 1)
Type: protein-coding
Summary: Involved in regulation of meiotic cell cycle. Acts upstream of or within reciprocal meiotic recombination and spermatogenesis. Located in chromosome. Orthologous to human CNTD1 (cyclin N-terminal domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: meiotic cell cycle, reciprocal meiotic recombination, regulation of meiotic cell cycle, spermatogenesis; CC: chromosome, cytoplasm, nucleus, site of double-strand break
Pathways:
UniProt: Q9D995
Entrez ID: 68107
|
Does Knockout of Unc13c in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Unc13c
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Unc13c (unc-13 homolog C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chemical synaptic transmission, dense core granule priming, exocytosis, modulation of chemical synaptic transmission, negative regulation of synaptic plasticity, synaptic transmission, glutamatergic, synaptic vesicle docking, synaptic vesicle exocytosis, synaptic vesicle priming; MF: calcium ion binding, calmodulin binding, diacylglycerol binding, metal ion binding, non-kinase phorbol ester receptor activity, phospholipid binding, syntaxin binding, syntaxin-1 binding, zinc ion binding; CC: calyx of Held, cell projection, cytoplasm, membrane, neuromuscular junction, parallel fiber to Purkinje cell synapse, plasma membrane, presynapse, presynaptic membrane, synapse, synaptic vesicle membrane, terminal bouton
Pathways: Synaptic vesicle cycle - Mus musculus (mouse)
UniProt: Q8K0T7
Entrez ID: 208898
|
Does Knockout of Nxf3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Nxf3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nxf3 (nuclear RNA export factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, poly(A)+ mRNA export from nucleus, protein transport; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding; CC: cytoplasm, cytoplasmic stress granule, nuclear RNA export factor complex, nuclear pore, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Nucleocytoplasmic transport - Mus musculus (mouse), Ribosome biogenesis in eukaryotes - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: B1AUS0, Q4ZGD9
Entrez ID: 245610
|
Does Knockout of Lcn9 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Lcn9
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lcn9 (lipocalin 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, small molecule binding; CC: extracellular region, extracellular space
Pathways: SLC-mediated transmembrane transport, Transport of fatty acids, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q9D267
Entrez ID: 77704
|
Does Knockout of Anln in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Anln
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Anln (anillin, actin binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actomyosin contractile ring assembly, cell division, hematopoietic progenitor cell differentiation, mitotic cytokinesis, podocyte cell migration, positive regulation of bleb assembly, septin ring organization; MF: actin binding, protein binding; CC: actin cytoskeleton, actomyosin contractile ring, bleb, cell cortex, cell projection, cytoplasm, cytoskeleton, midbody, nucleoplasm, nucleus
Pathways: RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8K298
Entrez ID: 68743
|
Does Knockout of Pdap1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Pdap1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pdap1 (PDGFA associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytosol, extracellular space, plasma membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q3UHX2
Entrez ID: 231887
|
Does Knockout of Zzz3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Zzz3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zzz3 (zinc finger, ZZ domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II; MF: DNA binding, histone binding, metal ion binding, zinc ion binding; CC: ATAC complex, mitotic spindle, nucleolus, nucleoplasm, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription)
UniProt: Q6KAQ7
Entrez ID: 108946
|
Does Knockout of Gltp in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Gltp
|
cell cycle progression
|
breast epithelium
|
Gene: Gltp (glycolipid transfer protein)
Type: protein-coding
Summary: Predicted to enable several functions, including ceramide 1-phosphate binding activity; ceramide 1-phosphate transfer activity; and identical protein binding activity. Predicted to be involved in ceramide transport and intermembrane lipid transfer. Predicted to be active in cytosol. Is expressed in several structures, including cerebral cortex ventricular layer; meninges; naris; and thymus primordium. Orthologous to human GLTP (glycolipid transfer protein). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: ceramide 1-phosphate transport, ceramide transport, intermembrane lipid transfer, lipid transport, response to immobilization stress; MF: ceramide 1-phosphate binding, ceramide 1-phosphate transfer activity, glycolipid binding, identical protein binding, lipid binding, lipid transfer activity; CC: cytoplasm, cytosol
Pathways: Glycosphingolipid transport, Transport of small molecules
UniProt: Q9JL62
Entrez ID: 56356
|
Does Knockout of Ppp6r2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Ppp6r2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ppp6r2 (protein phosphatase 6, regulatory subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein phosphatase binding, protein phosphatase regulator activity; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, nucleus
Pathways:
UniProt: A0A5F8MQ25, G3X9K4, Q8C3X1, Q8C400, A0A2I3BRV0
Entrez ID: 71474
|
Does Knockout of Pcdhgb2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Pcdhgb2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pcdhgb2 (protocadherin gamma subfamily B, 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, metal ion binding, protein binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q91XX7
Entrez ID: 93700
|
Does Knockout of Gm9755 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Gm9755
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gm9755 (Tu translation elongation factor pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100041265
|
Does Knockout of H2-Eb1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
H2-Eb1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: H2-Eb1 (histocompatibility 2, class II antigen E beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response, immune system process, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of immune response; MF: CD4 receptor binding, MHC class II protein complex binding, MHC class II receptor activity, T cell receptor binding, peptide antigen binding, polysaccharide binding, protein binding; CC: MHC class II protein complex, cell surface, external side of plasma membrane, immunological synapse, late endosome membrane, lysosomal membrane, membrane, plasma membrane
Pathways: Allograft rejection - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Asthma - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Intestinal immune network for IgA production - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: A0A498U6I0, O78196, A0A494B9C8
Entrez ID: 14969
|
Does Knockout of Tbcel in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Tbcel
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tbcel (tubulin folding cofactor E-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, post-chaperonin tubulin folding pathway, tubulin complex assembly; CC: cytoplasm, cytoskeleton
Pathways:
UniProt: Q8C5W3
Entrez ID: 272589
|
Does Knockout of Keap1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Keap1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Keap1 (kelch-like ECH-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to carbohydrate stimulus, cellular response to interleukin-4, cellular response to oxidative stress, in utero embryonic development, negative regulation of gene expression, negative regulation of response to oxidative stress, negative regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein ubiquitination, regulation of DNA-templated transcription, regulation of autophagy, regulation of epidermal cell differentiation, response to oxidative stress, ubiquitin-dependent protein catabolic process; MF: RNA polymerase II-specific DNA-binding transcription factor binding, disordered domain specific binding, identical protein binding, protein binding, transcription regulator inhibitor activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, actin filament, adherens junction, centriolar satellite, cytoplasm, cytosol, endoplasmic reticulum, focal adhesion, inclusion body, midbody, nucleoplasm, nucleus, protein-containing complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, Deubiquitination, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Immune System, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9Z2X8
Entrez ID: 50868
|
Does Knockout of Clec4a3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Clec4a3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Clec4a3 (C-type lectin domain family 4, member a3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, alpha-beta T cell activation, adaptive immune response, antifungal innate immune response, antigen processing and presentation of exogenous peptide antigen via MHC class I, immune system process, innate immune response, negative regulation of cytokine production, negative regulation of tumor necrosis factor production, plasmacytoid dendritic cell antigen processing and presentation, proteolysis; MF: D-mannose binding, aspartic-type endopeptidase activity, calcium ion binding, carbohydrate binding, metal ion binding, pattern recognition receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: A0A0N4SUX0, Q8JZX6
Entrez ID: 73149
|
Does Knockout of Arl13b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Arl13b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Arl13b (ADP-ribosylation factor-like 13B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, determination of left/right symmetry, dorsal/ventral pattern formation, formation of radial glial scaffolds, heart looping, interneuron migration from the subpallium to the cortex, left/right axis specification, neural tube patterning, non-motile cilium assembly, receptor localization to non-motile cilium, smoothened signaling pathway; MF: GTP binding, GTPase activity, nucleotide binding, protein binding; CC: axoneme, cell projection, ciliary basal body, ciliary membrane, cilium, cytosol, intercellular bridge, membrane, microtubule cytoskeleton, motile cilium, non-motile cilium, plasma membrane
Pathways: ARL13B-mediated ciliary trafficking of INPP5E, Aggrephagy, Autophagy, Cargo trafficking to the periciliary membrane, Cilium Assembly, Macroautophagy, Organelle biogenesis and maintenance, RHO GTPase cycle, RHOQ GTPase cycle, Selective autophagy, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q640N2
Entrez ID: 68146
|
Does Knockout of Sgo1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Sgo1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Sgo1 (shugoshin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, centriole-centriole cohesion, chromosome segregation, meiotic chromosome segregation, mitotic sister chromatid cohesion, centromeric; MF: kinase binding; CC: centrosome, chromosome, chromosome, centromeric region, condensed chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, nuclear speck, nucleoplasm, nucleus, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, EML4 and NUDC in mitotic spindle formation, G2/M Transition, M Phase, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CXH7
Entrez ID: 72415
|
Does Knockout of Qrsl1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Qrsl1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Qrsl1 (glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutaminyl-tRNAGln biosynthesis via transamidation, mitochondrial translation, regulation of protein stability, translation; MF: ATP binding, carbon-nitrogen ligase activity, with glutamine as amido-N-donor, catalytic activity, glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, ligase activity, nucleotide binding; CC: glutamyl-tRNA(Gln) amidotransferase complex, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q9CZN8
Entrez ID: 76563
|
Does Knockout of Dsn1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Dsn1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Dsn1 (DSN1 homolog, MIS12 kinetochore complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, skeletal muscle satellite cell proliferation; CC: MIS12/MIND type complex, chromosome, chromosome, centromeric region, cytosol, fibrillar center, kinetochore, nuclear body, nucleolus, nucleoplasm, nucleus, outer kinetochore, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, Immune System, Innate Immune System, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Neutrophil degranulation, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CYC5
Entrez ID: 66934
|
Does Knockout of Chchd5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Chchd5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Chchd5 (coiled-coil-helix-coiled-coil-helix domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial intermembrane space, mitochondrion
Pathways:
UniProt: Q9CQP3
Entrez ID: 66170
|
Does Knockout of Hspa9 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Hspa9
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hspa9 (heat shock protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium import into the mitochondrion, erythrocyte differentiation, iron-sulfur cluster assembly, negative regulation of erythrocyte differentiation, negative regulation of hematopoietic stem cell differentiation, negative regulation of hemopoiesis, positive regulation of apoptotic process, protein export from nucleus, protein folding, protein refolding, regulation of erythrocyte differentiation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, enzyme binding, fibroblast growth factor binding, heat shock protein binding, hydrolase activity, nucleotide binding, protein binding, protein folding chaperone, protein-folding chaperone binding, ubiquitin protein ligase binding, unfolded protein binding; CC: cytoplasm, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, myelin sheath, nucleolus, nucleus
Pathways: Aerobic respiration and respiratory electron transport, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Complex I biogenesis, Complex III assembly, Metabolism, Metabolism of proteins, Mitochondrial protein degradation, RNA degradation - Mus musculus (mouse), Regulation of HSF1-mediated heat shock response, Respiratory electron transport, Tuberculosis - Mus musculus (mouse)
UniProt: P38647
Entrez ID: 15526
|
Does Knockout of Ptchd4 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Ptchd4
|
phagocytosis
|
macrophage
|
Gene: Ptchd4 (patched domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane
Pathways:
UniProt: B9EKX1
Entrez ID: 627626
|
Does Knockout of Fh1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Fh1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fh1 (fumarate hydratase 1)
Type: protein-coding
Summary: Enables fumarate hydratase activity. Involved in several processes, including carboxylic acid metabolic process; positive regulation of cold-induced thermogenesis; and tricarboxylic acid cycle. Acts upstream of or within homeostasis of number of cells within a tissue. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA damage response, DNA repair, arginine metabolic process, fumarate metabolic process, homeostasis of number of cells within a tissue, malate metabolic process, positive regulation of cold-induced thermogenesis, positive regulation of double-strand break repair via nonhomologous end joining, regulation of arginine metabolic process, tricarboxylic acid cycle, urea cycle; MF: catalytic activity, fumarate hydratase activity, histone binding, lyase activity; CC: chromosome, cytoplasm, cytosol, mitochondrial matrix, mitochondrion, nucleus, site of double-strand break
Pathways: Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Cushing syndrome - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, Pathways in cancer - Mus musculus (mouse), Pyruvate metabolism - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), glutamate degradation VII
UniProt: P97807
Entrez ID: 14194
|
Does Knockout of Gm6083 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Gm6083
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gm6083 (predicted gene 6083)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Ddx41 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ddx41
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ddx41 (DEAD box helicase 41)
Type: protein-coding
Summary: Enables DNA binding activity. Acts upstream of or within cellular response to interferon-beta; defense response to virus; and positive regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum and nucleus. Is expressed in hippocampus; pancreas; and testis. Human ortholog(s) of this gene implicated in myeloproliferative neoplasm. Orthologous to human DDX41 (DEAD-box helicase 41). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, cGAS/STING signaling pathway, cell differentiation, cell population proliferation, cellular response to interferon-beta, defense response to virus, mRNA processing, mRNA splicing, via spliceosome, positive regulation of transcription by RNA polymerase II, positive regulation of type I interferon production; MF: ATP binding, ATP hydrolysis activity, DNA binding, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, mRNA binding, metal ion binding, nucleic acid binding, nucleotide binding, protein binding, zinc ion binding; CC: catalytic step 2 spliceosome, cytoplasm, cytosol, endoplasmic reticulum, nucleus, spliceosomal complex
Pathways: Cytosolic sensors of pathogen-associated DNA , Immune System, Innate Immune System, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Regulation of innate immune responses to cytosolic DNA, STING mediated induction of host immune responses, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q91VN6
Entrez ID: 72935
|
Does Knockout of Stk10 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Stk10
|
cell proliferation
|
Regulatory T cell
|
Gene: Stk10 (serine/threonine kinase 10)
Type: protein-coding
Summary: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: intracellular signal transduction, lymphocyte aggregation, protein autophosphorylation, regulation of cell migration, regulation of lymphocyte migration; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein homodimerization activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, membrane, nuclear body, nucleoplasm, plasma membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, Progesterone-mediated oocyte maturation - Mus musculus (mouse), RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O55098
Entrez ID: 20868
|
Does Knockout of Tpte in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Tpte
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tpte (transmembrane phosphatase with tensin homology)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, phosphate-containing compound metabolic process, transmembrane transport; MF: hydrolase activity, monoatomic ion channel activity, phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum membrane, membrane
Pathways: Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phospholipid metabolism, Synthesis of PIPs at the Golgi membrane
UniProt: A0A1B0GSB8, G5E8H5, A0A1B0GS38
Entrez ID: 234129
|
Does Knockout of Immp1l in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Immp1l
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Immp1l (IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein processing involved in protein targeting to mitochondrion, proteolysis, signal peptide processing; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: membrane, mitochondrial inner membrane, mitochondrial inner membrane peptidase complex, mitochondrion
Pathways: Protein export - Mus musculus (mouse)
UniProt: Q9CQU8
Entrez ID: 66541
|
Does Knockout of Rpsa in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Rpsa
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rpsa (ribosomal protein SA)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cytoplasmic translation, ribosomal small subunit assembly, translation; MF: DNA binding, laminin binding, laminin receptor activity, protein binding, ribosome binding, structural constituent of ribosome, structural molecule activity; CC: basement membrane, cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, glutamatergic synapse, membrane, neuronal cell body, nucleus, plasma membrane, postsynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P14206
Entrez ID: 16785
|
Does Knockout of Adam12 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Adam12
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adam12 (ADAM metallopeptidase domain 12)
Type: protein-coding
Summary: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein that localizes to the cell surface. About a third of the mice lacking the encoded protein die before weaning. Overexpression of the encoded protein in a mouse model of Duchenne muscular dystrophy alleviates the muscle pathology by preventing cell necrosis and inflammation. [provided by RefSeq, May 2016].
Gene Ontology: BP: cell adhesion, positive regulation of angiogenesis, proteolysis; MF: SH3 domain binding, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein binding; CC: membrane, nucleoplasm, plasma membrane
Pathways: Extracellular matrix organization, Invadopodia formation
UniProt: Q61824
Entrez ID: 11489
|
Does Knockout of Eef2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Eef2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eef2 (eukaryotic translation elongation factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to brain-derived neurotrophic factor stimulus, glial cell proliferation, hematopoietic progenitor cell differentiation, positive regulation of cytoplasmic translation, positive regulation of translation, response to endoplasmic reticulum stress, response to estradiol, response to ethanol, response to folic acid, response to hydrogen peroxide, response to ischemia, response to xenobiotic stimulus, skeletal muscle cell differentiation, skeletal muscle contraction, translation, translation at postsynapse, translational elongation; MF: 5S rRNA binding, GTP binding, GTPase activity, RNA binding, actin filament binding, hydrolase activity, lncRNA binding, nucleotide binding, p53 binding, protein binding, protein kinase binding, ribosome binding, translation elongation factor activity; CC: aggresome, cytoplasm, cytosol, glutamatergic synapse, nucleus, plasma membrane, postsynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: AMPK signaling pathway - Mus musculus (mouse), Eukaryotic Translation Elongation, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Oxytocin signaling pathway - Mus musculus (mouse), Peptide chain elongation, Post-translational protein modification, Protein methylation, Synthesis of diphthamide-EEF2, Translation
UniProt: P58252
Entrez ID: 13629
|
Does Knockout of Ankrd42 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Ankrd42
|
response to virus
|
Microglial Cell Line
|
Gene: Ankrd42 (ankyrin repeat domain 42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: NF-kappaB binding, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding; CC: nucleus
Pathways:
UniProt: Q3V096
Entrez ID: 73845
|
Does Knockout of Nae1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Nae1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nae1 (NEDD8 activating enzyme E1 subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, mitotic DNA replication checkpoint signaling, neuron apoptotic process, protein neddylation, regulation of apoptotic process, regulation of neuron apoptotic process, regulation of postsynapse assembly; MF: NEDD8 activating enzyme activity, protein heterodimerization activity, ubiquitin protein ligase binding, ubiquitin-like modifier activating enzyme activity; CC: early endosome, glutamatergic synapse, membrane, plasma membrane, protein-containing complex
Pathways: Alzheimer disease - Mus musculus (mouse), Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q8VBW6
Entrez ID: 234664
|
Does Knockout of Med15 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Med15
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Med15 (mediator complex subunit 15)
Type: protein-coding
Summary: Predicted to enable transcription coregulator activity. Acts upstream of or within somatic stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of core mediator complex. Is expressed in several structures, including branchial arch; central nervous system; facial prominence; limb; and limb bud. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MED15 (mediator complex subunit 15). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of DNA-templated transcription, somatic stem cell population maintenance; CC: core mediator complex, cytoplasm, mediator complex, nucleoplasm, nucleus
Pathways:
UniProt: Q924H2
Entrez ID: 94112
|
Does Knockout of Banf1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Banf1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Banf1 (BAF nuclear assembly factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA integration, DNA repair, cGAS/STING signaling pathway, chromatin organization, chromosome organization, establishment of integrated proviral latency, mitotic nuclear membrane reassembly, negative regulation of cGAS/STING signaling pathway, negative regulation of innate immune response, negative regulation of protein ADP-ribosylation, negative regulation of type I interferon production, negative regulation of viral genome replication, positive regulation of type I interferon production, response to oxidative stress; MF: DNA binding, double-stranded DNA binding, identical protein binding, protein homodimerization activity; CC: chromatin, chromosome, condensed chromosome, cytoplasm, cytosol, nuclear envelope, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown
UniProt: O54962
Entrez ID: 23825
|
Does Knockout of Casr in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Casr
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Casr (calcium-sensing receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, JNK cascade, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, bile acid secretion, branching morphogenesis of an epithelial tube, cellular response to glucose stimulus, cellular response to hepatocyte growth factor stimulus, cellular response to hypoxia, cellular response to low-density lipoprotein particle stimulus, cellular response to peptide, cellular response to vitamin D, chloride transmembrane transport, detection of calcium ion, establishment of localization in cell, fat pad development, intracellular calcium ion homeostasis, ossification, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of calcium ion import, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of insulin secretion, positive regulation of positive chemotaxis, positive regulation of vasoconstriction, regulation of calcium ion transport, regulation of presynaptic membrane potential, response to calcium ion, response to fibroblast growth factor, response to ischemia, response to metal ion, signal transduction, vasodilation; MF: G protein-coupled receptor activity, amino acid binding, calcium ion binding, identical protein binding, integrin binding, metal ion binding, protein homodimerization activity, protein kinase binding, transmembrane transporter binding; CC: apical plasma membrane, axon, axon terminus, basolateral plasma membrane, cell surface, glutamatergic synapse, membrane, neuronal cell body, plasma membrane, presynaptic membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, NOD-like receptor signaling pathway - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q9QY96
Entrez ID: 12374
|
Does Knockout of Slc25a26 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Slc25a26
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Slc25a26 (solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alpha-amino acid transmembrane transport, S-adenosyl-L-methionine transport, mitochondrial S-adenosyl-L-methionine transmembrane transport, purine nucleoside transmembrane transport, transmembrane transport; MF: S-adenosyl-L-methionine transmembrane transporter activity, S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity, antiporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: SLC-mediated transmembrane transport, SLC-mediated transport of organic cations, Transport of small molecules
UniProt: Q5U680
Entrez ID: 67582
|
Does Knockout of Fis1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Fis1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Fis1 (fission, mitochondrial 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to peptide, mitochondrial fission, mitochondrial fragmentation involved in apoptotic process, mitochondrion organization, negative regulation of ATP metabolic process, negative regulation of fatty acid transport, peroxisome fission, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of mitochondrial fission, positive regulation of neuron apoptotic process, protein targeting to mitochondrion, response to endoplasmic reticulum stress; MF: identical protein binding, lipid binding, molecular adaptor activity; CC: membrane, mitochondrial outer membrane, mitochondrion, peroxisomal membrane, peroxisome, protein-containing complex
Pathways: Class I peroxisomal membrane protein import, Mitophagy - animal - Mus musculus (mouse), Protein localization
UniProt: Q9CQ92
Entrez ID: 66437
|
Does Knockout of Col11a2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Col11a2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Col11a2 (collagen, type XI, alpha 2)
Type: protein-coding
Summary: This gene encodes the alpha-2 subunit of type XI collagen, one of the low abundance fibrillar collagens found in cartilage. The encoded protein, in association with other collagen subunits, forms a heterotrimeric type XI procollagen that may undergo proteolytic processing similar to the alpha-1 subunit. Mice lacking the encoded protein exhibit a mild phenotype similar to nonocular Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED) as well as a nonsyndromic form of deafness called DFNA13. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: cartilage development, chondrocyte differentiation, collagen fibril organization, roof of mouth development, sensory perception of sound, skeletal system development, skeletal system morphogenesis, soft palate development, tissue homeostasis; MF: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, metal ion binding; CC: collagen trimer, collagen type XI trimer, extracellular matrix, extracellular region
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Extracellular matrix organization, MET activates PTK2 signaling, MET promotes cell motility, Non-integrin membrane-ECM interactions, Protein digestion and absorption - Mus musculus (mouse), Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases
UniProt: Q64739
Entrez ID: 12815
|
Does Knockout of Grk1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Grk1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Grk1 (G protein-coupled receptor kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of neuron apoptotic process, photoreceptor cell morphogenesis, positive regulation of phosphorylation, post-embryonic retina morphogenesis in camera-type eye, protein autophosphorylation, regulation of opsin-mediated signaling pathway, regulation of signal transduction, response to light stimulus, retinal rod cell apoptotic process, signal transduction, visual perception; MF: ATP binding, G protein-coupled receptor kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, rhodopsin kinase activity, transferase activity; CC: cell projection, cytoplasm, membrane, photoreceptor outer segment
Pathways: Chemokine signaling pathway - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Phototransduction - Mus musculus (mouse)
UniProt: Q4V9Z9, G3X905
Entrez ID: 24013
|
Does Knockout of Vmn1r135 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Vmn1r135
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Vmn1r135 (vomeronasal 1 receptor 135)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: K9J7G0
Entrez ID: 667404
|
Does Knockout of Sntg2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Sntg2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Sntg2 (syntrophin, gamma 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: PDZ domain binding, actin binding, neuroligin family protein binding, protein binding, structural molecule activity; CC: cytoplasm, cytoskeleton, dystrophin-associated glycoprotein complex, membrane, nucleoplasm, plasma membrane, sarcolemma, syntrophin complex
Pathways: Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Non-integrin membrane-ECM interactions
UniProt: Q925E0
Entrez ID: 268534
|
Does Knockout of Slc14a2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Slc14a2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc14a2 (solute carrier family 14 (urea transporter), member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: urea transmembrane transport, urea transport; MF: cell adhesion molecule binding, urea transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, plasma membrane
Pathways: SLC-mediated transmembrane transport, SLC-mediated transport of organic cations, Transport of small molecules
UniProt: Q8R4T9
Entrez ID: 27411
|
Does Knockout of D030056L22Rik in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
D030056L22Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: D030056L22Rik (RIKEN cDNA D030056L22 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8VCE4
Entrez ID: 225995
|
Does Knockout of Adgrl3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Adgrl3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adgrl3 (adhesion G protein-coupled receptor L3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell adhesion, cell surface receptor signaling pathway, cell-cell adhesion via plasma-membrane adhesion molecules, excitatory synapse assembly, locomotion involved in locomotory behavior, maintenance of postsynaptic specialization structure, neuron migration, positive regulation of synapse assembly, response to cocaine, signal transduction, synapse assembly, synapse organization; MF: G protein-coupled receptor activity, calcium ion binding, carbohydrate binding, cell adhesion mediator activity, metal ion binding, molecular condensate scaffold activity, protein binding, transmembrane signaling receptor activity; CC: Schaffer collateral - CA1 synapse, anchoring junction, axon, cell projection, cell-cell junction, glutamatergic synapse, membrane, plasma membrane, postsynaptic membrane, synapse
Pathways:
UniProt: Q80TS3
Entrez ID: 319387
|
Does Knockout of Prrg2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Prrg2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Prrg2 (proline-rich Gla (G-carboxyglutamic acid) polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, blood coagulation, proteolysis; MF: calcium ion binding, protein binding, serine-type endopeptidase activity; CC: extracellular region, extracellular space, membrane, plasma membrane
Pathways:
UniProt: Q8R182
Entrez ID: 65116
|
Does Knockout of Nek11 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Nek11
|
cell cycle progression
|
breast epithelium
|
Gene: Nek11 (NIMA (never in mitosis gene a)-related expressed kinase 11)
Type: protein-coding
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in mitotic intra-S DNA damage checkpoint signaling; protein phosphorylation; and regulation of mitotic cell cycle phase transition. Predicted to be located in nucleolus. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cartilage; central nervous system; genitourinary system; and respiratory system. Orthologous to human NEK11 (NIMA related kinase 11). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: intracellular signal transduction, mitotic intra-S DNA damage checkpoint signaling, protein phosphorylation, regulation of mitotic cell cycle phase transition; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: nucleolus, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, G1/S DNA Damage Checkpoints, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q8C0Q4
Entrez ID: 208583
|
Does Knockout of Glo1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Glo1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Glo1 (glyoxalase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutathione metabolic process, methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione, methylglyoxal metabolic process, negative regulation of apoptotic process, osteoclast differentiation, regulation of transcription by RNA polymerase II; MF: lactoylglutathione lyase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytosol, nucleoplasm, plasma membrane
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), methylglyoxal degradation I
UniProt: Q9CPU0
Entrez ID: 109801
|
Does Knockout of Magea10 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Magea10
|
response to virus
|
Microglial Cell Line
|
Gene: Magea10 (MAGE family member A10)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor binding activity; histone deacetylase binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; gonad; heart; and liver. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: CC: cytosol, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: A2AMW4
Entrez ID: 236852
|
Does Knockout of Has2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Has2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Has2 (hyaluronan synthase 2)
Type: protein-coding
Summary: Enables hyaluronan synthase activity. Involved in several processes, including circulatory system development; extracellular matrix assembly; and hyaluronan biosynthetic process. Acts upstream of or within bone morphogenesis and hyaluronan metabolic process. Located in cytoplasmic vesicle and plasma membrane raft. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; heart; and skin. Orthologous to human HAS2 (hyaluronan synthase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: atrioventricular canal development, bone morphogenesis, cellular response to fluid shear stress, cellular response to interleukin-1, cellular response to platelet-derived growth factor stimulus, cellular response to tumor necrosis factor, endocardial cushion to mesenchymal transition, estrous cycle, extracellular matrix assembly, glycosaminoglycan biosynthetic process, hyaluronan biosynthetic process, hyaluronan metabolic process, kidney development, polysaccharide biosynthetic process, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of hyaluronan biosynthetic process, positive regulation of keratinocyte migration, positive regulation of keratinocyte proliferation, positive regulation of monocyte aggregation, positive regulation of smooth muscle cell migration, positive regulation of substrate adhesion-dependent cell spreading, positive regulation of urine volume, regulation of extracellular matrix assembly, renal water absorption, vasculogenesis; MF: glycosyltransferase activity, hyaluronan synthase activity, identical protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular vesicle, lysosome, membrane, plasma membrane, plasma membrane raft, vesicle
Pathways: Glycosaminoglycan metabolism, Hyaluronan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: P70312
Entrez ID: 15117
|
Does Knockout of Zfp628 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Zfp628
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Zfp628 (zinc finger protein 628)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: developmental process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8CJ78
Entrez ID: 232816
|
Does Knockout of Foxj1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Foxj1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Foxj1 (forkhead box J1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, axoneme assembly, brain development, cell maturation, cell projection organization, central tolerance induction, ciliary basal body organization, cilium assembly, determination of left/right symmetry, epithelium development, establishment of apical/basal cell polarity, glomerular parietal epithelial cell development, heart development, humoral immune response, intracellular protein localization, left/right pattern formation, leukocyte migration, lung epithelium development, metanephric part of ureteric bud development, motile cilium assembly, negative regulation of B cell activation, negative regulation of T cell differentiation in thymus, negative regulation of T cell proliferation, negative regulation of germinal center formation, negative regulation of humoral immune response mediated by circulating immunoglobulin, negative regulation of interleukin-6 production, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of central B cell tolerance induction, positive regulation of lung ciliated cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of epithelial cell differentiation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: nucleus
Pathways:
UniProt: Q61660
Entrez ID: 15223
|
Does Knockout of Rtn4rl1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Rtn4rl1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rtn4rl1 (reticulon 4 receptor-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, corpus callosum development, negative chemotaxis, negative regulation of axon regeneration, negative regulation of neuron projection development; MF: Roundabout binding, chondroitin sulfate binding, heparin binding, signaling receptor activity; CC: cell projection, cell surface, membrane, membrane raft, perikaryon, plasma membrane, side of membrane
Pathways:
UniProt: Q8K0S5
Entrez ID: 237847
|
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