prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Peli3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Peli3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Peli3 (pellino 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to Gram-negative bacterium, immune system process, innate immune response, negative regulation of Toll signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of protein ubiquitination, negative regulation of tumor necrosis factor-mediated signaling pathway, negative regulation of type I interferon production, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, protein K63-linked ubiquitination, protein polyubiquitination, protein ubiquitination, regulation of Toll signaling pathway, regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; MF: protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity
Pathways: Cytokine Signaling in Immune system, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Signaling by Interleukins, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q8BXR6
Entrez ID: 240518
|
Does Knockout of Rpn2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Rpn2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rpn2 (ribophorin II)
Type: protein-coding
Summary: Predicted to enable ribosome binding activity. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in autophagosome membrane; endoplasmic reticulum; and nuclear body. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; brain; ear; heart; and integumental system. Orthologous to human RPN2 (ribophorin II). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: protein N-linked glycosylation, protein glycosylation; MF: protein binding, ribosome binding; CC: autophagosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear body, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, N-Glycan biosynthesis - Mus musculus (mouse), PD-L1(CD274) glycosylation and translocation to plasma membrane, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q9DBG6
Entrez ID: 20014
|
Does Knockout of Pira4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Pira4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pira4 (paired-Ig-like receptor A4)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: B cell receptor signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse)
UniProt: A2NTK1
Entrez ID: 18727
|
Does Knockout of Slc25a36 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Slc25a36
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Slc25a36 (solute carrier family 25, member 36)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrion organization, nucleotide transport, pyrimidine nucleotide import into mitochondrion, pyrimidine nucleotide transport, regulation of mitochondrial membrane potential, transmembrane transport; MF: pyrimidine nucleotide transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q922G0
Entrez ID: 192287
|
Does Knockout of Arl8a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Arl8a
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Arl8a (ADP-ribosylation factor-like 8A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal transport, cell division, chromosome segregation, protein transport; MF: GTP binding, GTPase activity, nucleotide binding; CC: axon, axon cytoplasm, cell projection, cytoplasm, cytoskeleton, endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, midbody, spindle, spindle midzone, synapse
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, Salmonella infection - Mus musculus (mouse)
UniProt: Q8VEH3
Entrez ID: 68724
|
Does Knockout of Apold1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Apold1
|
phagocytosis
|
macrophage
|
Gene: Apold1 (apolipoprotein L domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, autophagosome-dependent secretion, lipid transport, lipoprotein metabolic process, regulation of endothelial cell differentiation, regulation of membrane permeability; MF: lipid binding; CC: Weibel-Palade body, cell-cell junction, extracellular region, membrane
Pathways:
UniProt: E9Q0X2
Entrez ID: 381823
|
Does Knockout of Il23a in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Il23a
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Il23a (interleukin 23, alpha subunit p19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, defense response to Gram-negative bacterium, defense response to virus, immune response, immune system process, inflammatory response, innate immune response, negative regulation of interleukin-10 production, positive regulation of NK T cell activation, positive regulation of NK T cell proliferation, positive regulation of T cell mediated cytotoxicity, positive regulation of T cell proliferation, positive regulation of T-helper 1 type immune response, positive regulation of T-helper 17 cell lineage commitment, positive regulation of T-helper 17 type immune response, positive regulation of activated T cell proliferation, positive regulation of alpha-beta T cell activation, positive regulation of defense response to virus by host, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-17 production, positive regulation of leukocyte differentiation, positive regulation of macromolecule biosynthetic process, positive regulation of memory T cell differentiation, positive regulation of natural killer cell proliferation, positive regulation of neutrophil chemotaxis, positive regulation of osteoclast differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, regulation of gene expression, regulation of primary metabolic process, tissue remodeling; MF: cytokine activity, interleukin-23 receptor binding, protein binding; CC: extracellular region, extracellular space, interleukin-23 complex
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-12 family signaling, Interleukin-23 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Signaling by Interleukins, Th17 cell differentiation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q9EQ14
Entrez ID: 83430
|
Does Knockout of Spint3 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Spint3
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Spint3 (serine peptidase inhibitor, Kunitz type, 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q3UW09
Entrez ID: 629747
|
Does Knockout of Ncf4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Ncf4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ncf4 (neutrophil cytosolic factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phagocytosis, respiratory burst, superoxide anion generation; MF: lipid binding, phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding, superoxide-generating NADPH oxidase activator activity; CC: NADPH oxidase complex, cytoplasm, cytosol, endosome, endosome membrane, membrane
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Cross-presentation of particulate exogenous antigens (phagosomes), Detoxification of Reactive Oxygen Species, Diabetic cardiomyopathy - Mus musculus (mouse), Immune System, Innate Immune System, Leishmaniasis - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate NADPH Oxidases, ROS and RNS production in phagocytes, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: P97369
Entrez ID: 17972
|
Does Knockout of Cflar in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Cflar
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cflar (CASP8 and FADD-like apoptosis regulator)
Type: protein-coding
Summary: Enables peptidase activator activity. Involved in several processes, including negative regulation of myoblast fusion; positive regulation of NF-kappaB transcription factor activity; and skeletal muscle atrophy. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway; negative regulation of necroptotic process; and response to bacterium. Located in cytoplasm. Is expressed in several structures, including central nervous system; gut; heart; peripheral nervous system ganglion; and retina. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: apoptotic process, cellular response to nitric oxide, extrinsic apoptotic signaling pathway via death domain receptors, macrophage differentiation, negative regulation of apoptotic process, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cellular response to transforming growth factor beta stimulus, negative regulation of epithelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of hepatocyte apoptotic process, negative regulation of myoblast fusion, negative regulation of necroptotic process, negative regulation of reactive oxygen species biosynthetic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of extracellular matrix organization, positive regulation of glomerular mesangial cell proliferation, positive regulation of hepatocyte proliferation, positive regulation of neuron apoptotic process, positive regulation of neuron projection development, proteolysis, regulation of apoptotic process, regulation of necroptotic process, regulation of skeletal muscle satellite cell proliferation, response to bacterium, response to testosterone, skeletal muscle atrophy, skeletal muscle tissue development, skeletal muscle tissue regeneration, skeletal myofibril assembly; MF: cysteine-type endopeptidase activity, cysteine-type peptidase activity, death receptor binding, enzyme activator activity, peptidase activator activity, protease binding, protein binding, protein-containing complex binding; CC: CD95 death-inducing signaling complex, cytoplasm, death-inducing signaling complex, ripoptosome
Pathways: Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: O35732
Entrez ID: 12633
|
Does Knockout of Slc38a7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Slc38a7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Slc38a7 (solute carrier family 38, member 7)
Type: protein-coding
Summary: Enables L-glutamine:sodium symporter activity. Involved in glutamine transport and sodium ion transport. Located in axon and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human SLC38A7 (solute carrier family 38 member 7). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: amino acid transmembrane transport, amino acid transport, asparagine transport, glutamine transport, monoatomic ion transport, sodium ion transport; MF: L-asparagine transmembrane transporter activity, L-asparagine:sodium symporter activity, L-glutamine transmembrane transporter activity, L-glutamine:sodium symporter activity; CC: axon, cell projection, lysosomal membrane, lysosome, membrane, neuronal cell body
Pathways:
UniProt: Q8BWH0
Entrez ID: 234595
|
Does Knockout of Speer4d in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Speer4d
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Speer4d (spermatogenesis associated glutamate (E)-rich protein 4D)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D3W2, L7N216, L7N261
Entrez ID: 360220
|
Does Knockout of Srsf12 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Srsf12
|
cell cycle progression
|
breast epithelium
|
Gene: Srsf12 (serine and arginine-rich splicing factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA 5'-splice site recognition, mRNA processing, regulation of alternative mRNA splicing, via spliceosome
Pathways:
UniProt: Q8C8K3
Entrez ID: 272009
|
Does Knockout of Rtf1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rtf1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rtf1 (RTF1, Paf1/RNA polymerase II complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, blastocyst growth, chromatin organization, endodermal cell fate commitment, negative regulation of transcription by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II; MF: DNA binding, RNA polymerase II C-terminal domain phosphoserine binding, protein binding, single-stranded DNA binding; CC: Cdc73/Paf1 complex, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: A2AQ19
Entrez ID: 76246
|
Does Knockout of Dhdds in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Dhdds
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Dhdds (dehydrodolichyl diphosphate synthase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichyl diphosphate biosynthetic process, dolichyl monophosphate biosynthetic process, lipid metabolic process, polyprenol biosynthetic process, protein glycosylation; MF: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity, metal ion binding, prenyltransferase activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: dehydrodolichyl diphosphate synthase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, Post-translational protein modification, Synthesis of dolichyl-phosphate, Synthesis of substrates in N-glycan biosythesis, Terpenoid backbone biosynthesis - Mus musculus (mouse)
UniProt: Q99KU1
Entrez ID: 67422
|
Does Knockout of Chrdl2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Chrdl2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Chrdl2 (chordin-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cartilage development, cell differentiation, chondrocyte differentiation, negative regulation of BMP signaling pathway, ossification, system development; MF: BMP binding, protein binding
Pathways:
UniProt: Q8VEA6
Entrez ID: 69121
|
Does Knockout of Skint3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Skint3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Skint3 (selection and upkeep of intraepithelial T cells 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, T cell receptor signaling pathway, regulation of T cell activation, regulation of cytokine production, regulation of leukocyte cell-cell adhesion; CC: external side of plasma membrane, membrane
Pathways:
UniProt: A7TZF0
Entrez ID: 195564
|
Does Knockout of Sod2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Sod2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sod2 (superoxide dismutase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure, apoptotic mitochondrial changes, cellular response to ethanol, cellular response to oxidative stress, detection of oxygen, erythrophore differentiation, glutathione metabolic process, heart development, hemopoiesis, hydrogen peroxide biosynthetic process, hydrogen peroxide metabolic process, intracellular oxygen homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to oxidative stress, liver development, locomotory behavior, mitochondrion organization, multicellular organismal-level iron ion homeostasis, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of fat cell differentiation, negative regulation of fibroblast proliferation, negative regulation of membrane hyperpolarization, negative regulation of neuron apoptotic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of vascular associated smooth muscle cell proliferation, neuron development, positive regulation of cell migration, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of nitric oxide biosynthetic process, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching, post-embryonic development, protein homotetramerization, regulation of blood pressure, regulation of mitochondrial membrane potential, regulation of transcription by RNA polymerase II, release of cytochrome c from mitochondria, removal of superoxide radicals, respiratory electron transport chain, response to L-ascorbic acid, response to activity, response to axon injury, response to cadmium ion, response to electrical stimulus, response to gamma radiation, response to hydrogen peroxide, response to hyperoxia, response to hypoxia, response to immobilization stress, response to isolation stress, response to lipopolysaccharide, response to magnetism, response to manganese ion, response to nutrient levels, response to oxidative stress, response to oxygen levels, response to reactive oxygen species, response to selenium ion, response to silicon dioxide, response to superoxide, response to xenobiotic stimulus, response to zinc ion, superoxide anion generation, superoxide metabolic process, vasodilation; MF: DNA binding, enzyme binding, identical protein binding, manganese ion binding, metal ion binding, oxidoreductase activity, oxygen binding, protein binding, superoxide dismutase activity; CC: cytoplasm, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, myelin sheath
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Detoxification of Reactive Oxygen Species, FoxO signaling pathway - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Mitochondrial biogenesis, Organelle biogenesis and maintenance, Peroxisome - Mus musculus (mouse), Transcriptional activation of mitochondrial biogenesis, superoxide radicals degradation
UniProt: P09671
Entrez ID: 20656
|
Does Knockout of Krtap31-1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Krtap31-1
|
cell cycle progression
|
breast epithelium
|
Gene: Krtap31-1 (keratin associated protein 31-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, hair cycle; CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q9D644
Entrez ID: 70831
|
Does Knockout of Anapc7 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Anapc7
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Anapc7 (anaphase promoting complex subunit 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, brain development, cell division, positive regulation of mitotic metaphase/anaphase transition, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination; MF: enzyme-substrate adaptor activity, protein phosphatase binding; CC: anaphase-promoting complex, cytoplasm, cytoskeleton, heterochromatin, intercellular bridge, microtubule cytoskeleton, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9WVM3
Entrez ID: 56317
|
Does Knockout of Rpap1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Rpap1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rpap1 (RNA polymerase II associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, nucleotidyltransferase activity, transferase activity; CC: DNA-directed RNA polymerase complex, RNA polymerase complex, nucleus
Pathways:
UniProt: Q80TE0
Entrez ID: 68925
|
Does Knockout of Cyp4a31 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Cyp4a31
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cyp4a31 (cytochrome P450, family 4, subfamily a, polypeptide 31)
Type: protein-coding
Summary: Predicted to enable monooxygenase activity. Predicted to be involved in several processes, including fatty acid metabolic process; icosanoid metabolic process; and positive regulation of icosanoid secretion. Predicted to be located in apical plasma membrane and cytoplasm. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: arachidonate metabolic process, fatty acid metabolic process, icosanoid biosynthetic process, kidney development, lauric acid metabolic process, linoleic acid metabolic process; MF: 16-hydroxypalmitate dehydrogenase activity, alkane 1-monooxygenase activity, arachidonate epoxygenase activity, arachidonate monooxygenase activity, heme binding, iron ion binding, leukotriene-B4 20-monooxygenase activity, long-chain fatty acid omega-hydroxylase activity, medium-chain fatty acid omega-hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; CC: apical plasma membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular space, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Fatty acids, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Metabolism, Metabolism of lipids, Miscellaneous substrates, PPAR signaling pathway - Mus musculus (mouse), Phase I - Functionalization of compounds, Retinol metabolism - Mus musculus (mouse), Synthesis of Leukotrienes (LT) and Eoxins (EX), Vascular smooth muscle contraction - Mus musculus (mouse)
UniProt: F8WGU9, Q91WU1, A2A8S8, A2A8S9
Entrez ID: 666168
|
Does Knockout of Hlx in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Hlx
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Hlx (H2.0-like homeobox)
Type: protein-coding
Summary: Predicted to enable sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic digestive tract morphogenesis; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and gut. Orthologous to human HLX (H2.0 like homeobox). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: animal organ development, cell differentiation, embryonic digestive tract morphogenesis, enteric nervous system development, liver development, negative regulation of T-helper 2 cell differentiation, positive regulation of T-helper 1 cell differentiation, positive regulation of epithelial cell proliferation, positive regulation of organ growth, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal muscle tissue development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific DNA binding
Pathways:
UniProt: Q61670
Entrez ID: 15284
|
Does Knockout of Pkp2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,278
|
Knockout
|
Pkp2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pkp2 (plakophilin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adherens junction maintenance, bundle of His cell-Purkinje myocyte adhesion involved in cell communication, cardiac muscle cell action potential, cardiac muscle cell action potential involved in contraction, cell adhesion, cell-cell adhesion, cell-cell signaling, desmosome assembly, desmosome organization, gap junction assembly, heart development, intermediate filament bundle assembly, lipid homeostasis, maintenance of animal organ identity, maintenance of protein localization at cell tip, negative regulation of cell migration, negative regulation of cell population proliferation, positive regulation of cell adhesion, protein localization to plasma membrane, regulation of bicellular tight junction assembly, regulation of cell-substrate adhesion, regulation of heart rate by cardiac conduction, regulation of substrate adhesion-dependent cell spreading, regulation of ventricular cardiac muscle cell action potential, ventricular cardiac muscle cell action potential, ventricular cardiac muscle tissue morphogenesis; MF: DNA binding, alpha-catenin binding, cadherin binding, intermediate filament binding, molecular adaptor activity, protein binding, protein kinase C binding; CC: adherens junction, anchoring junction, cell junction, cell tip, cell-cell junction, cytoplasm, desmosome, intercalated disc, intermediate filament, nucleoplasm, nucleus, plasma membrane
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q9CQ73
Entrez ID: 67451
|
Does Knockout of Yrdc in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Yrdc
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Yrdc (yrdC domain containing (E.coli))
Type: protein-coding
Summary: Predicted to enable L-threonylcarbamoyladenylate synthase and tRNA binding activity. Predicted to be involved in regulation of translational fidelity and tRNA threonylcarbamoyladenosine modification. Predicted to act upstream of or within negative regulation of transport. Located in membrane. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human YRDC (yrdC N6-threonylcarbamoyltransferase domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of transport, regulation of translational fidelity, tRNA threonylcarbamoyladenosine modification; MF: L-threonylcarbamoyladenylate synthase, double-stranded RNA binding, nucleotidyltransferase activity, protein binding, tRNA binding, transferase activity; CC: cytoplasm, membrane, mitochondrion, plasma membrane
Pathways: Metabolism of RNA, tRNA modification in the mitochondrion, tRNA processing
UniProt: Q3U5F4
Entrez ID: 230734
|
Does Knockout of Pygo2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Pygo2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pygo2 (pygopus 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: kidney development, spermatid nucleus differentiation
Pathways: Formation of the beta-catenin:TCF transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q80V76, Q3V113
Entrez ID: 68911
|
Does Knockout of Krtap13-1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Krtap13-1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Krtap13-1 (keratin associated protein 13-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q8K198
Entrez ID: 268905
|
Does Knockout of Arid1b in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Arid1b
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Arid1b (AT-rich interaction domain 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, dendritic cell dendrite assembly, dendritic spine development, nervous system development, neuron-neuron synaptic transmission, positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, nucleosome binding, protein binding; CC: SWI/SNF complex, brahma complex, cytosol, nBAF complex, nucleoplasm, nucleus, plasma membrane, synapse
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: E9Q4N7
Entrez ID: 239985
|
Does Knockout of Acmsd in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Acmsd
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Acmsd (amino carboxymuconate semialdehyde decarboxylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-tryptophan catabolic process, negative regulation of quinolinate biosynthetic process, quinolinate metabolic process, secondary metabolic process; MF: aminocarboxymuconate-semialdehyde decarboxylase activity, carboxy-lyase activity, hydrolase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytoplasm, cytosol
Pathways: 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA, Tryptophan metabolism - Mus musculus (mouse), tryptophan degradation III (eukaryotic)
UniProt: Q8R519
Entrez ID: 266645
|
Does Knockout of Ubl4a in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ubl4a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ubl4a (ubiquitin-like 4A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: post-translational protein targeting to endoplasmic reticulum membrane, regulation of protein stability, tail-anchored membrane protein insertion into ER membrane, ubiquitin-dependent protein catabolic process; MF: protein-folding chaperone binding; CC: BAT3 complex, cytoplasm, cytosol, membrane, nucleoplasm, nucleus
Pathways:
UniProt: P21126
Entrez ID: 27643
|
Does Knockout of F13a1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
F13a1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: F13a1 (coagulation factor XIII, A1 subunit)
Type: protein-coding
Summary: This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: blood coagulation, blood coagulation, fibrin clot formation, hemostasis, peptide cross-linking; MF: acyltransferase activity, metal ion binding, protein-glutamine gamma-glutamyltransferase activity, transferase activity; CC: cytoplasm, extracellular matrix, extracellular region
Pathways: Common Pathway of Fibrin Clot Formation, Complement and coagulation cascades - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Formation of Fibrin Clot (Clotting Cascade), Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q8BH61
Entrez ID: 74145
|
Does Knockout of Tmem41b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Tmem41b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tmem41b (transmembrane protein 41B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, host-mediated perturbation of viral RNA genome replication, intracellular lipid transport, lipid transport, nervous system development, plasma membrane phospholipid scrambling; MF: phospholipid scramblase activity; CC: endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondria-associated endoplasmic reticulum membrane contact site
Pathways:
UniProt: Q8K1A5
Entrez ID: 233724
|
Does Knockout of Rock2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Rock2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Rock2 (Rho-associated coiled-coil containing protein kinase 2)
Type: protein-coding
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of nitric oxide biosynthetic process; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway via death domain receptors; nervous system development; and positive regulation of centrosome duplication. Located in spindle pole centrosome. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; heart; musculature; and somite. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Rho protein signal transduction, actin cytoskeleton organization, actomyosin structure organization, blood vessel diameter maintenance, cellular response to acetylcholine, centrosome duplication, cortical actin cytoskeleton organization, dendrite morphogenesis, embryonic morphogenesis, epithelial to mesenchymal transition, extrinsic apoptotic signaling pathway via death domain receptors, host-mediated perturbation of viral process, mRNA destabilization, mitotic cytokinesis, negative regulation of angiogenesis, negative regulation of bicellular tight junction assembly, negative regulation of gene expression, negative regulation of nitric oxide biosynthetic process, negative regulation of protein localization to lysosome, neural tube closure, positive regulation of MAPK cascade, positive regulation of amyloid precursor protein catabolic process, positive regulation of amyloid-beta formation, positive regulation of cardiac muscle hypertrophy, positive regulation of cell migration, positive regulation of centrosome duplication, positive regulation of connective tissue growth factor production, positive regulation of connective tissue replacement, positive regulation of fibroblast growth factor production, positive regulation of gene expression, positive regulation of protein localization to early endosome, positive regulation of stress fiber assembly, postsynaptic actin cytoskeleton organization, protein localization to plasma membrane, regulation of actin cytoskeleton organization, regulation of angiotensin-activated signaling pathway, regulation of cell junction assembly, regulation of cellular response to hypoxia, regulation of circadian rhythm, regulation of establishment of endothelial barrier, regulation of keratinocyte differentiation, regulation of nervous system process, regulation of synapse maturation, response to angiotensin, response to ischemia, response to transforming growth factor beta, rhythmic process, signal transduction, smooth muscle contraction, stress fiber assembly; MF: ATP binding, Rho-dependent protein serine/threonine kinase activity, endopeptidase activator activity, kinase activity, metal ion binding, nucleotide binding, protease binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, small GTPase binding, transferase activity, zinc ion binding; CC: Schaffer collateral - CA1 synapse, centrosome, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoskeleton, cytosol, glutamatergic synapse, membrane, neuromuscular junction, nucleus, plasma membrane, postsynaptic density, presynaptic active zone, spindle pole centrosome
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Focal adhesion - Mus musculus (mouse), G alpha (12/13) signalling events, GPCR downstream signalling, Human cytomegalovirus infection - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Nervous system development, Oxytocin signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate ROCKs, RHOA GTPase cycle, RHOB GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, RHOC GTPase cycle, RHOH GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Semaphorin interactions, Signal Transduction, Signaling by GPCR, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Sphingolipid signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Vascular smooth muscle contraction - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P70336
Entrez ID: 19878
|
Does Knockout of Ccdc115 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Ccdc115
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ccdc115 (coiled-coil domain containing 115)
Type: protein-coding
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in cellular response to increased oxygen levels; intracellular monoatomic cation homeostasis; and lysosomal protein catabolic process. Located in lysosome. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spinal cord. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIo. Orthologous to human CCDC115 (coiled-coil domain containing 115). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to increased oxygen levels, intracellular iron ion homeostasis, lysosomal lumen acidification, lysosomal protein catabolic process, vacuolar proton-transporting V-type ATPase complex assembly; CC: COPI-coated vesicle, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, endosome, lysosome, vacuolar proton-transporting V-type ATPase complex, vacuole
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8VE99
Entrez ID: 69668
|
Does Knockout of Thoc5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Thoc5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Thoc5 (THO complex 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, blastocyst development, cell differentiation, cell morphogenesis, mRNA export from nucleus, mRNA processing, mRNA transport, monocyte differentiation, negative regulation of macrophage differentiation, primitive hemopoiesis, regulation of gene expression, regulation of mRNA export from nucleus, regulation of stem cell division, stem cell division; MF: RNA binding, mRNA binding, protein binding; CC: THO complex, THO complex part of transcription export complex, chromosome, telomeric region, cytoplasm, cytosol, nucleoplasm, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q8BKT7
Entrez ID: 107829
|
Does Knockout of Thoc6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Thoc6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Thoc6 (THO complex 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic process, central nervous system development, mRNA export from nucleus, mRNA processing, mRNA transport; MF: RNA binding, protein binding; CC: THO complex, THO complex part of transcription export complex, chromosome, telomeric region, nuclear body, nuclear speck, nucleoplasm, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q5U4D9
Entrez ID: 386612
|
Does Knockout of Ets2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Ets2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ets2 (E26 avian leukemia oncogene 2, 3' domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, ectodermal cell fate commitment, mesoderm development, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, primitive streak formation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, nuclear glucocorticoid receptor binding, protein domain specific binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytosol, nucleoplasm, nucleus, plasma membrane
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Oncogene Induced Senescence, Ras signaling pathway - Mus musculus (mouse)
UniProt: P15037
Entrez ID: 23872
|
Does Knockout of Trappc8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Trappc8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trappc8 (trafficking protein particle complex 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII vesicle coating, Golgi organization, collagen biosynthetic process, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle tethering; CC: TRAPP complex, TRAPPIII protein complex, cytoplasm
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q69ZT3, A0A286YCX6, E9PY51, Q8BJI6, A0A286YCE0
Entrez ID: 75964
|
Does Knockout of Fsd1l in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Fsd1l
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fsd1l (fibronectin type III and SPRY domain containing 1-like)
Type: protein-coding
Summary: Orthologous to human FSD1L (fibronectin type III and SPRY domain containing 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q8BYN5
Entrez ID: 319636
|
Does Knockout of Hoga1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Hoga1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hoga1 (4-hydroxy-2-oxoglutarate aldolase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glyoxylate catabolic process, glyoxylate metabolic process, oxalate metabolic process, pyruvate biosynthetic process, trans-4-hydroxy-L-proline catabolic process; MF: (4S)-4-hydroxy-2-oxoglutarate aldolase activity, (R,S)-4-hydroxy-2-oxoglutarate aldolase activity, lyase activity, protein homodimerization activity; CC: mitochondrion
Pathways: <i>N</i>-acetylneuraminate and <i>N</i>-acetylmannosamine degradation, Arginine and proline metabolism - Mus musculus (mouse), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Glyoxylate metabolism and glycine degradation, Metabolism, Metabolism of amino acids and derivatives, superpathway of <i>N</i>-acetylglucosamine, <i>N</i>-acetylmannosamine and <i>N</i>-acetylneuraminate degradation
UniProt: Q9DCU9
Entrez ID: 67432
|
Does Knockout of Parg in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Parg
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Parg (poly (ADP-ribose) glycohydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP generation from poly-ADP-D-ribose, DNA damage response, carbohydrate metabolic process, detection of bacterium, nucleotide-sugar metabolic process, positive regulation of DNA repair, regulation of DNA repair; MF: chromatin binding, hydrolase activity, poly(ADP-ribose) glycohydrolase activity; CC: chromatin, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: O88622
Entrez ID: 26430
|
Does Knockout of Qtrt2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Qtrt2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Qtrt2 (queuine tRNA-ribosyltransferase accessory subunit 2)
Type: protein-coding
Summary: Predicted to enable protein heterodimerization activity; protein homodimerization activity; and tRNA binding activity. Involved in tRNA-guanine transglycosylation. Located in cytoplasmic side of mitochondrial outer membrane. Part of protein-containing complex. Orthologous to human QTRT2 (queuine tRNA-ribosyltransferase accessory subunit 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: tRNA modification, tRNA processing, tRNA wobble guanine modification; MF: metal ion binding, protein binding, protein heterodimerization activity, protein homodimerization activity, tRNA binding, tRNA-guanosine(34) queuine transglycosylase activity, zinc ion binding; CC: cytoplasm, cytoplasmic side of mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion, protein-containing complex, tRNA-guanine transglycosylase complex, transferase complex
Pathways:
UniProt: B8ZXI1
Entrez ID: 106248
|
Does Knockout of Zfp2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Zfp2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp2 (zinc finger protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: P08043
Entrez ID: 22678
|
Does Knockout of Ikbkg in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Ikbkg
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ikbkg (inhibitor of kappaB kinase gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell homeostasis, DNA damage response, anoikis, canonical NF-kappaB signal transduction, defense response to bacterium, establishment of vesicle localization, negative regulation of canonical NF-kappaB signal transduction, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of gene expression, positive regulation of macroautophagy, positive regulation of transcription by RNA polymerase II, protein-containing complex assembly, regulation of transcription by RNA polymerase II, tumor necrosis factor-mediated signaling pathway; MF: K63-linked polyubiquitin modification-dependent protein binding, identical protein binding, linear polyubiquitin binding, metal ion binding, peroxisome proliferator activated receptor binding, polyubiquitin modification-dependent protein binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein homodimerization activity, protein-containing complex binding, signaling adaptor activity, transferrin receptor binding, ubiquitin protein ligase binding, zinc ion binding; CC: IkappaB kinase complex, cytoplasm, cytosol, mitotic spindle, nucleus, protein-containing complex, spindle pole, ubiquitin ligase complex
Pathways: Activation of NF-kappaB in B cells, Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Apoptosis - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytosolic DNA-sensing pathway - Mus musculus (mouse), Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, Death Receptor Signaling, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IKK complex recruitment mediated by RIP1, IL-17 signaling pathway - Mus musculus (mouse), IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Interferon Signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, Modulation of host responses by IFN-stimulated genes, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), NOD1/2 Signaling Pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Osteoclast differentiation - Mus musculus (mouse), Ovarian tumor domain proteases, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PKR-mediated signaling, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Primary immunodeficiency - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), RIP-mediated NFkB activation via ZBP1, Ras signaling pathway - Mus musculus (mouse), Regulation of NF-kappa B signaling, Regulation of TNFR1 signaling, Response of endothelial cells to shear stress, SLC15A4:TASL-dependent IRF5 activation, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of immune response proteins, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Signaling by the B Cell Receptor (BCR), Small cell lung cancer - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TAK1-dependent IKK and NF-kappa-B activation , TCR signaling, TNF signaling, TNF signaling pathway - Mus musculus (mouse), TNFR1-induced NF-kappa-B signaling pathway, TRAF6 mediated NF-kB activation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Ub-specific processing proteases, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), ZBP1(DAI) mediated induction of type I IFNs, activated TAK1 mediates p38 MAPK activation
UniProt: O88522
Entrez ID: 16151
|
Does Knockout of Gm20840 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gm20840
|
phagocytosis
|
macrophage
|
Gene: Gm20840 (predicted gene, 20840)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 108168599
|
Does Knockout of Zeb1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Zeb1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Zeb1 (zinc finger E-box binding homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, cartilage development, cell differentiation, cellular response to amino acid stimulus, central nervous system development, cochlea morphogenesis, embryonic camera-type eye morphogenesis, embryonic morphogenesis, embryonic skeletal system morphogenesis, negative regulation of DNA-templated transcription, negative regulation of endothelial cell differentiation, negative regulation of epithelial cell differentiation, negative regulation of epithelial cell proliferation, negative regulation of keratinocyte proliferation, negative regulation of transcription by RNA polymerase II, nervous system development, pattern specification process, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of T cell differentiation in thymus, regulation of mesenchymal cell proliferation, regulation of smooth muscle cell differentiation, regulation of transcription by RNA polymerase II, regulation of transforming growth factor beta receptor signaling pathway, semicircular canal morphogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, double-stranded DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, MicroRNAs in cancer - Mus musculus (mouse), Negative Regulation of CDH1 Gene Transcription, Prostate cancer - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q64318
Entrez ID: 21417
|
Does Knockout of Ints11 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ints11
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ints11 (integrator complex subunit 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, snRNA 3'-end processing, snRNA processing, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: RNA endonuclease activity, hydrolase activity, metal ion binding; CC: INTAC complex, cytoplasm, cytosol, integrator complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q9CWS4
Entrez ID: 71957
|
Does Knockout of Trit1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Trit1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Trit1 (tRNA isopentenyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial tRNA modification, tRNA modification, tRNA processing; MF: ATP binding, metal ion binding, nucleotide binding, tRNA dimethylallyltransferase activity, transferase activity, zinc ion binding; CC: cytoplasm, mitochondrion, nucleus
Pathways:
UniProt: Q80UN9
Entrez ID: 66966
|
Does Knockout of Grm5 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Grm5
|
response to virus
|
Microglial Cell Line
|
Gene: Grm5 (glutamate receptor, metabotropic 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled glutamate receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway, associative learning, cellular response to amyloid-beta, chemical synaptic transmission, cognition, conditioned place preference, desensitization of G protein-coupled receptor signaling pathway, learning, learning or memory, locomotory behavior, modulation of chemical synaptic transmission, negative regulation of dendritic spine morphogenesis, negative regulation of excitatory postsynaptic potential, operant conditioning, phospholipase C-activating G protein-coupled glutamate receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of calcium-mediated signaling, positive regulation of cellular response to hypoxia, positive regulation of cytosolic calcium ion concentration, positive regulation of dopamine secretion, positive regulation of intracellular signal transduction, positive regulation of long-term neuronal synaptic plasticity, positive regulation of neural precursor cell proliferation, positive regulation of sensory perception of pain, protein localization to nuclear inner membrane, regulation of DNA-templated transcription, regulation of long-term neuronal synaptic plasticity, regulation of long-term synaptic depression, regulation of postsynaptic cytosolic calcium ion concentration, regulation of postsynaptic membrane potential, regulation of synaptic transmission, glutamatergic, response to amphetamine, response to antibiotic, response to corticosterone, response to ethanol, response to morphine, sensory perception of hot stimulus, signal transduction, synapse organization, temperature homeostasis; MF: A2A adenosine receptor binding, G protein-coupled receptor activity, G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential, PLC activating G protein-coupled glutamate receptor activity, adenylate cyclase inhibiting G protein-coupled glutamate receptor activity, glutamate receptor activity, identical protein binding, neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration, protein binding, protein tyrosine kinase activator activity, protein tyrosine kinase binding; CC: Schaffer collateral - CA1 synapse, astrocyte projection, cytoplasm, dendrite, dendritic shaft, dendritic spine, glutamatergic synapse, membrane, neuron projection, neuron spine, neuronal cell body, nuclear inner membrane, plasma membrane, postsynaptic density membrane, postsynaptic membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Gap junction - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Neurexins and neuroligins, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Protein-protein interactions at synapses, Retrograde endocannabinoid signaling - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q3UVX5
Entrez ID: 108071
|
Does Knockout of Prdm10 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Prdm10
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Prdm10 (PR domain containing 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, metal ion binding, zinc ion binding; CC: chromatin, nucleus, transcription repressor complex
Pathways:
UniProt:
Entrez ID: 382066
|
Does Knockout of Ndufb9 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Ndufb9
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ndufb9 (NADH:ubiquinone oxidoreductase subunit B9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQJ8
Entrez ID: 66218
|
Does Knockout of Slc44a1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Slc44a1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc44a1 (solute carrier family 44, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: choline transport, ethanolamine transport, transmembrane transport; MF: antiporter activity, choline transmembrane transporter activity, ethanolamine transmembrane transporter activity, organic cation transmembrane transporter activity, transmembrane transporter activity; CC: cytosol, membrane, mitochondrial outer membrane, mitochondrion, nucleoplasm, plasma membrane
Pathways: Choline catabolism, Choline metabolism in cancer - Mus musculus (mouse), Glycerophospholipid biosynthesis, Metabolism, Metabolism of amino acids and derivatives, Metabolism of lipids, Phospholipid metabolism, SLC-mediated bile acid transport, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Synthesis of PC, Transport of small molecules
UniProt: Q6X893
Entrez ID: 100434
|
Does Knockout of Gjd4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Gjd4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gjd4 (gap junction protein, delta 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell communication, cell-cell signaling, regulation of satellite cell activation involved in skeletal muscle regeneration, transmembrane transport; CC: anchoring junction, connexin complex, gap junction, membrane, plasma membrane
Pathways: Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q8BSD4
Entrez ID: 225152
|
Does Knockout of Npy in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Npy
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Npy (neuropeptide Y)
Type: protein-coding
Summary: This gene encodes a neuropeptide that plays a pivotal role in many physiological functions such as food intake, energy homeostasis, circadian rhythm, and cognition. The encoded protein precursor undergoes proteolytic processing to generate the biologically active peptide. Mice lacking the encoded protein exhibit mild seizures occasionally and become hyperphagic following food deprivation. A deficiency of the encoded protein partially prevents mice lacking leptin from becoming obese. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: adult feeding behavior, antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, central nervous system neuron development, cerebral cortex development, chemical synaptic transmission, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, developmental growth, drinking behavior, feeding behavior, innate immune response, monocyte activation, negative regulation of acute inflammatory response to antigenic stimulus, negative regulation of blood pressure, neuron projection development, neuropeptide signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of appetite, positive regulation of cell population proliferation, positive regulation of cell-substrate adhesion, positive regulation of dopamine metabolic process, positive regulation of eating behavior, positive regulation of nitric oxide metabolic process, regulation of blood pressure, regulation of nerve growth factor production, regulation of presynaptic cytosolic calcium ion concentration, regulation of synaptic vesicle exocytosis, response to yeast, short-day photoperiodism, synaptic signaling via neuropeptide; MF: G protein-coupled receptor binding, hormone activity, neuropeptide Y receptor binding, neuropeptide hormone activity; CC: GABA-ergic synapse, Golgi apparatus, cytoplasm, cytoplasmic vesicle, extracellular region, extracellular space, neuronal dense core vesicle, perikaryon, perinuclear region of cytoplasm, terminal bouton
Pathways: Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Regulation of lipolysis in adipocytes - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: P57774
Entrez ID: 109648
|
Does Knockout of Pcdha6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Pcdha6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pcdha6 (protocadherin alpha 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: B9EKB6, Q91Y14, A0A0A6YY55
Entrez ID: 12937
|
Does Knockout of Insl3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Insl3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Insl3 (insulin-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, in utero embryonic development, male gonad development, negative regulation of apoptotic process, negative regulation of cell population proliferation, oocyte maturation, positive regulation of cAMP/PKA signal transduction, positive regulation of cell population proliferation, positive regulation of epithelial cell migration, positive regulation of wound healing, regulation of male gonad development; MF: hormone activity, protease binding; CC: extracellular region, extracellular space, perinuclear region of cytoplasm
Pathways: Neuroactive ligand-receptor interaction - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse)
UniProt: Q5RL10
Entrez ID: 16336
|
Does Knockout of Ccr5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ccr5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ccr5 (C-C motif chemokine receptor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, MAPK cascade, apoptotic process, calcium ion transport, calcium-mediated signaling, cell chemotaxis, cell-cell signaling, cellular response to lipopolysaccharide, chemokine-mediated signaling pathway, chemotaxis, defense response, immune response, inflammatory response, negative regulation of axon extension, negative regulation of macrophage apoptotic process, negative regulation of neural precursor cell proliferation, positive regulation of cell killing, positive regulation of cell-cell adhesion, positive regulation of cytosolic calcium ion concentration, positive regulation of fever generation, positive regulation of gene expression, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, positive regulation of neuron apoptotic process, positive regulation of neuron differentiation, positive regulation of tumor necrosis factor production, regulation of cell migration, release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, response to cholesterol, signal transduction, signaling; MF: C-C chemokine binding, C-C chemokine receptor activity, G protein-coupled receptor activity, actin binding, chemokine (C-C motif) ligand 5 binding, chemokine receptor activity, identical protein binding, protein kinase binding; CC: cell surface, cytoplasm, endosome, external side of plasma membrane, membrane, plasma membrane
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Toxoplasmosis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P51682
Entrez ID: 12774
|
Does Knockout of Tbcc in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Tbcc
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tbcc (tubulin-specific chaperone C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: post-chaperonin tubulin folding pathway, protein folding, tubulin complex assembly; MF: GTPase activity, tubulin binding; CC: cytoplasm, cytosol, endoplasmic reticulum, photoreceptor connecting cilium
Pathways:
UniProt: Q8VCN9
Entrez ID: 72726
|
Does Knockout of Nub1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Nub1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nub1 (negative regulator of ubiquitin-like proteins 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, protein ubiquitination, proteolysis involved in protein catabolic process, regulation of ubiquitin-dependent protein catabolic process, response to tumor necrosis factor, response to type II interferon, ubiquitin-dependent protein catabolic process; CC: Lewy body, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: P54729
Entrez ID: 53312
|
Does Knockout of Dnajc17 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Dnajc17
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dnajc17 (DnaJ heat shock protein family (Hsp40) member C17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, spliceosomal complex disassembly; MF: RNA binding, nucleic acid binding; CC: cytoplasm, nucleus, spliceosomal complex
Pathways:
UniProt: Q91WT4
Entrez ID: 69408
|
Does Knockout of Fbxl21 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Fbxl21
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fbxl21 (F-box and leucine-rich repeat protein 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: entrainment of circadian clock by photoperiod, protein ubiquitination, rhythmic process; CC: SCF ubiquitin ligase complex, cytoplasm, cytosol, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q8BFZ4
Entrez ID: 213311
|
Does Knockout of Sprn in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Sprn
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sprn (shadow of prion protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein import into nucleus; MF: nucleic acid binding; CC: cytosol, membrane, nucleolus, nucleus, plasma membrane, side of membrane, vesicle
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q8BWU1
Entrez ID: 212518
|
Does Knockout of Mir6373 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mir6373
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mir6373 (microRNA 6373)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102466636
|
Does Knockout of Mall in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Mall
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Mall (mal, T cell differentiation protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi membrane, clathrin-coated vesicle, cytoplasmic vesicle, membrane, membrane raft, plasma membrane
Pathways:
UniProt: Q91X49
Entrez ID: 228576
|
Does Knockout of Uqcc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Uqcc1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Uqcc1 (ubiquinol-cytochrome c reductase complex assembly factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex III assembly; CC: cytoplasmic vesicle, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CWU6
Entrez ID: 56046
|
Does Knockout of Ttc1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ttc1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ttc1 (tetratricopeptide repeat domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, inflammatory response, positive regulation of inflammatory response, positive regulation of neuroinflammatory response; MF: molecular_function, protein-macromolecule adaptor activity; CC: cytosol
Pathways:
UniProt: Q91Z38
Entrez ID: 66827
|
Does Knockout of Hdlbp in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 1
| 1,522
|
Knockout
|
Hdlbp
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Hdlbp (high density lipoprotein (HDL) binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol metabolic process, lipid metabolic process, lipid transport, steroid metabolic process; MF: RNA binding, mRNA binding, nucleic acid binding; CC: cytoplasm, high-density lipoprotein particle, nucleus
Pathways: HDL clearance, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Transport of small molecules
UniProt: Q8VDJ3
Entrez ID: 110611
|
Does Knockout of Mcoln2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Mcoln2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Mcoln2 (mucolipin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, immune system process, innate immune response, iron ion transmembrane transport, macrophage migration, monoatomic ion transmembrane transport, monoatomic ion transport, neutrophil migration, positive regulation of chemokine (C-C motif) ligand 5 production, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of chemokine production, positive regulation of macrophage inflammatory protein 1 alpha production, positive regulation of monocyte chemotactic protein-1 production, protein transport, regulation of chemokine (C-X-C motif) ligand 2 production; MF: NAADP-sensitive calcium-release channel activity, calcium channel activity, identical protein binding, iron ion transmembrane transporter activity, monoatomic cation channel activity, monoatomic cation transmembrane transporter activity; CC: endosome, lysosomal membrane, lysosome, membrane, plasma membrane, recycling endosome, recycling endosome membrane
Pathways: Calcium signaling pathway - Mus musculus (mouse), Ion channel transport, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q8K595
Entrez ID: 68279
|
Does Knockout of Efna5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Efna5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Efna5 (ephrin A5)
Type: protein-coding
Summary: Enables chemorepellent activity; ephrin receptor binding activity; and neurotrophin TRKB receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; positive regulation of nervous system development; and synaptic membrane adhesion. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus; cellular response to forskolin; and retinal ganglion cell axon guidance. Located in adherens junction; basement membrane; and plasma membrane. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; embryo ectoderm; limb; nervous system; and sensory organ. Used to study anencephaly. Orthologous to human EFNA5 (ephrin A5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: axon guidance, cell differentiation, cellular response to follicle-stimulating hormone stimulus, cellular response to forskolin, collateral sprouting, ephrin receptor signaling pathway, negative chemotaxis, negative regulation of substrate adhesion-dependent cell spreading, nervous system development, positive regulation of collateral sprouting, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of synapse assembly, regulation of GTPase activity, regulation of actin cytoskeleton organization, regulation of cell morphogenesis, regulation of cell-cell adhesion, regulation of focal adhesion assembly, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of microtubule cytoskeleton organization, retinal ganglion cell axon guidance, synaptic membrane adhesion; MF: chemorepellent activity, ephrin receptor binding, neurotrophin TRKB receptor binding, protein binding; CC: GABA-ergic synapse, adherens junction, basement membrane, caveola, cell periphery, external side of plasma membrane, membrane, plasma membrane, side of membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA-mediated growth cone collapse, MAPK signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Nervous system development, PI3K-Akt signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse)
UniProt: O08543
Entrez ID: 13640
|
Does Knockout of Spink6 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Spink6
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Spink6 (serine peptidase inhibitor, Kazal type 6)
Type: protein-coding
Summary: Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within negative regulation of serine-type endopeptidase activity. Located in extracellular region. Orthologous to human SPINK6 (serine peptidase inhibitor Kazal type 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q8BT20
Entrez ID: 433180
|
Does Knockout of Stpg4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Stpg4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Stpg4 (sperm tail PG rich repeat containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, epigenetic programing of male pronucleus, pyrimidine-containing compound catabolic process; MF: chromatin binding, histone binding, protein binding; CC: cytoplasm, female germ cell nucleus, female pronucleus, germinal vesicle, male germ cell nucleus, male pronucleus, nucleoplasm, nucleus
Pathways:
UniProt: Q9DAG5
Entrez ID: 75467
|
Does Knockout of Ano7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ano7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ano7 (anoctamin 7)
Type: protein-coding
Summary: This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. In humans, this protein is primarily found in prostate tissues and may serve as a target for prostate cancer immunotherapy. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: calcium activated galactosylceramide scrambling, calcium activated phosphatidylcholine scrambling, calcium activated phosphatidylserine scrambling, calcium activated phospholipid scrambling, chloride transmembrane transport, chloride transport, establishment of localization in cell, lipid transport; MF: chloride channel activity, intracellularly calcium-gated chloride channel activity, phospholipid scramblase activity, protein dimerization activity; CC: endoplasmic reticulum, membrane, nucleus, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q14AT5
Entrez ID: 404545
|
Does Knockout of Tmem201 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Tmem201
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tmem201 (transmembrane protein 201)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, centrosome localization, fibroblast migration, nuclear envelope organization, nuclear migration, nuclear migration along microtubule, positive regulation of endothelial cell migration, protein localization to nuclear envelope; MF: actin filament binding, lamin binding, protein binding; CC: cortical endoplasmic reticulum, membrane, nuclear envelope, nuclear inner membrane, nuclear membrane, nucleus, spindle pole centrosome
Pathways:
UniProt: A2A8U2
Entrez ID: 230917
|
Does Knockout of Fam20c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Fam20c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fam20c (FAM20C, golgi associated secretory pathway kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biomineral tissue development, dentinogenesis, enamel mineralization, odontoblast differentiation, osteoclast maturation, positive regulation of bone mineralization, positive regulation of osteoblast differentiation, protein phosphorylation, regulation of fibroblast growth factor receptor signaling pathway, regulation of phosphorus metabolic process, skeletal system development; MF: ATP binding, calcium ion binding, kinase activity, manganese ion binding, metal ion binding, nucleotide binding, protease binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum, extracellular region, extracellular space, membrane, nucleoplasm
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q5MJS3
Entrez ID: 80752
|
Does Knockout of Ube2e3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Ube2e3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ube2e3 (ubiquitin-conjugating enzyme E2E 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of gene expression, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein K63-linked ubiquitination, protein monoubiquitination, protein ubiquitination; MF: ATP binding, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity; CC: cytoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P52483
Entrez ID: 22193
|
Does Knockout of Khnyn in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Khnyn
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Khnyn (KH and NYN domain containing)
Type: protein-coding
Summary: This gene encodes a protein with a C-terminal RNA modifying domain that belongs to a family of ribonucleases typified by eukaryotic Nedd4-binding protein1 and the bacterial YacP-like nucleases (NYN). The NYN domain shares a common protein fold with two other groups of nucleases, the PilT N-terminal nuclease and FLAP nuclease superfamilies. In addition to the NYN domain, the protein encoded by this gene also contains an N-terminal K homology RNA-binding domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].
Gene Ontology: MF: RNA endonuclease activity, mRNA binding; CC: cytoplasmic ribonucleoprotein granule, nucleus
Pathways:
UniProt: Q80U38
Entrez ID: 219094
|
Does Knockout of Zbtb8b in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Zbtb8b
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Zbtb8b (zinc finger and BTB domain containing 8b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8CII0
Entrez ID: 215627
|
Does Knockout of Mvd in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mvd
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mvd (mevalonate (diphospho) decarboxylase)
Type: protein-coding
Summary: Predicted to enable Hsp70 protein binding activity; diphosphomevalonate decarboxylase activity; and protein homodimerization activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and positive regulation of cell population proliferation. Located in cytosol. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, isopentenyl diphosphate biosynthetic process, mevalonate pathway, isoprenoid biosynthetic process, lipid metabolic process, positive regulation of cell population proliferation, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: ATP binding, Hsp70 protein binding, carboxy-lyase activity, diphosphomevalonate decarboxylase activity, lyase activity, nucleotide binding, protein homodimerization activity; CC: cytoplasm, cytosol, peroxisomal matrix, peroxisome
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, Post-translational protein modification, Synthesis of dolichyl-phosphate, Synthesis of substrates in N-glycan biosythesis, Terpenoid backbone biosynthesis - Mus musculus (mouse), mevalonate pathway I, superpathway of cholesterol biosynthesis
UniProt: Q99JF5
Entrez ID: 192156
|
Does Knockout of Mier2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Mier2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mier2 (MIER family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, histone deacetylase activity, histone deacetylase binding, transcription corepressor activity; CC: cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q3U3N0
Entrez ID: 70427
|
Does Knockout of Nlrc5 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,157
|
Knockout
|
Nlrc5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nlrc5 (NLR family, CARD domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, immune system process, innate immune response, negative regulation of NF-kappaB transcription factor activity, negative regulation of type I interferon-mediated signaling pathway, positive regulation of MHC class I biosynthetic process, positive regulation of transcription by RNA polymerase II, positive regulation of type I interferon-mediated signaling pathway, positive regulation of type II interferon-mediated signaling pathway, response to bacterium; MF: ATP binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, nucleotide binding; CC: centrosome, cytoplasm, cytosol, nucleus
Pathways: Cytokine Signaling in Immune system, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Regulation of NF-kappa B signaling, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: C3VPR6
Entrez ID: 434341
|
Does Knockout of Eif4enif1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Eif4enif1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Eif4enif1 (eukaryotic translation initiation factor 4E nuclear import factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P-body assembly, mRNA stabilization, miRNA-mediated gene silencing by inhibition of translation, negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA, negative regulation of neuron differentiation, negative regulation of translation, nuclear export, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, protein import into nucleus, protein transport, regulation of translation, regulatory ncRNA-mediated gene silencing, stem cell population maintenance; MF: kinase binding, mRNA binding, nuclear export signal receptor activity, protein binding; CC: P-body, PML body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, nuclear speck, nucleus
Pathways:
UniProt: Q9EST3
Entrez ID: 74203
|
Does Knockout of Vps11 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,171
|
Knockout
|
Vps11
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Vps11 (VPS11, CORVET/HOPS core subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, endosomal vesicle fusion, endosome organization, endosome to lysosome transport, intracellular protein transport, negative regulation of intracellular estrogen receptor signaling pathway, organelle fusion, positive regulation of early endosome to late endosome transport, positive regulation of protein catabolic process, protein transport, protein ubiquitination, regulation of organelle assembly, vacuole organization, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: metal ion binding, nucleotide binding, protein binding, protein domain specific binding, protein-macromolecule adaptor activity, syntaxin binding, ubiquitin protein ligase activity, zinc ion binding; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, actin filament, autophagosome, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endocytic vesicle, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, presynaptic active zone, vesicle tethering complex
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q91W86
Entrez ID: 71732
|
Does Knockout of Myo9b in macrophage causally result in phagocytosis?
| 1
| 1,888
|
Knockout
|
Myo9b
|
phagocytosis
|
macrophage
|
Gene: Myo9b (myosin IXb)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, Roundabout signaling pathway, actin filament-based movement, actin-myosin filament sliding, establishment of cell polarity, intracellular signal transduction, lamellipodium morphogenesis, macrophage chemotaxis, monocyte chemotaxis, regulation of Rho protein signal transduction, signal transduction; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent protein binding, GTPase activator activity, Roundabout binding, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, metal ion binding, microfilament motor activity, nucleotide binding, small GTPase binding, zinc ion binding; CC: actin filament, cell cortex, cytoplasm, cytoskeleton, cytosol, filopodium tip, lamellipodium, myosin complex, perinuclear region of cytoplasm, postsynaptic actin cytoskeleton, ruffle
Pathways:
UniProt: E9PWZ6, Q3TRQ0, E9PZW8, A0A1D5RLW4, A0A8V5KX73
Entrez ID: 17925
|
Does Knockout of Hrh1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Hrh1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hrh1 (histamine receptor H1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, calcium ion import, calcium ion transmembrane transport, cellular response to histamine, chemical synaptic transmission, manganese ion transmembrane transport, memory, negative regulation of steroid biosynthetic process, phospholipase C-activating serotonin receptor signaling pathway, positive regulation of nitric oxide biosynthetic process, positive regulation of vasoconstriction, regulation of synaptic plasticity, regulation of vascular permeability, rhythmic process, signal transduction, visual learning; MF: G protein-coupled receptor activity, calcium ion transmembrane transporter activity, histamine binding, histamine receptor activity; CC: cytosol, dendrite, membrane, plasma membrane, synapse
Pathways: Amine ligand-binding receptors, Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Histamine receptors, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P70174
Entrez ID: 15465
|
Does Knockout of Tjp1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Tjp1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tjp1 (tight junction protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actomyosin structure organization, adherens junction maintenance, ameloblast differentiation, blastocyst formation, cell-cell adhesion, cell-cell junction organization, establishment of endothelial intestinal barrier, negative regulation of apoptotic process, negative regulation of stress fiber assembly, positive regulation of blood-brain barrier permeability, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cell-cell adhesion mediated by cadherin, positive regulation of sprouting angiogenesis, protein localization to adherens junction, protein localization to bicellular tight junction, protein localization to cell-cell junction, regulation of bicellular tight junction assembly, regulation of cell junction assembly, regulation of cytoskeleton organization, sensory perception of sound; MF: beta-catenin binding, calmodulin binding, cell adhesion molecule binding, connexin binding, protein binding, protein domain specific binding, transmembrane transporter binding; CC: I band, adherens junction, anchoring junction, apical junction complex, apical part of cell, apical plasma membrane, apicolateral plasma membrane, basolateral plasma membrane, bicellular tight junction, cell junction, cell surface, cell-cell junction, cytoplasm, cytosol, gap junction, intercalated disc, intercellular canaliculus, membrane, nucleus, plasma membrane, protein-containing complex, tight junction
Pathways: Adherens junction - Mus musculus (mouse), Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Gap junction - Mus musculus (mouse), Gap junction trafficking and regulation, Membrane Trafficking, Programmed Cell Death, Regulation of gap junction activity, Signal Transduction, Signaling by Hippo, Tight junction - Mus musculus (mouse), Vesicle-mediated transport
UniProt: P39447
Entrez ID: 21872
|
Does Knockout of Asns in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Asns
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Asns (asparagine synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-asparagine biosynthetic process, amino acid biosynthetic process, asparagine biosynthetic process, cellular response to glucose starvation, negative regulation of apoptotic process, positive regulation of mitotic cell cycle; MF: ATP binding, asparagine synthase (glutamine-hydrolyzing) activity, identical protein binding, ligase activity, nucleotide binding; CC: cytosol
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Aspartate and asparagine metabolism, Metabolism, Metabolism of amino acids and derivatives, asparagine biosynthesis I
UniProt: Q61024
Entrez ID: 27053
|
Does Knockout of Tomm22 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Tomm22
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tomm22 (translocase of outer mitochondrial membrane 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, positive regulation of apoptotic process, protein import into mitochondrial matrix, protein insertion into mitochondrial membrane, protein targeting to mitochondrion, protein transport; MF: mitochondrion targeting sequence binding, protein binding, protein transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion
Pathways: Autophagy, Macroautophagy, Mitophagy, PINK1-PRKN Mediated Mitophagy, Selective autophagy
UniProt: Q9CPQ3
Entrez ID: 223696
|
Does Knockout of Supt5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Supt5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Supt5 (suppressor of Ty 5, DSIF elongation factor subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription elongation, negative regulation of DNA-templated transcription, elongation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, elongation, positive regulation of macroautophagy, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of DNA-templated transcription elongation, regulation of transcription by RNA polymerase II, regulation of transcription elongation by RNA polymerase II, transcription elongation by RNA polymerase II; MF: chromatin binding, enzyme binding, mRNA binding, protein heterodimerization activity; CC: DSIF complex, nucleoplasm, nucleus
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA polymerase II transcribes snRNA genes, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53, mRNA Capping
UniProt: O55201
Entrez ID: 20924
|
Does Knockout of Srsf1 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Srsf1
|
response to virus
|
Microglial Cell Line
|
Gene: Srsf1 (serine and arginine-rich splicing factor 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, cardiac muscle contraction, cellular response to interleukin-17, in utero embryonic development, interleukin-17-mediated signaling pathway, liver regeneration, mRNA 5'-splice site recognition, mRNA processing, mRNA stabilization, mRNA transport, oligodendrocyte differentiation, positive regulation of RNA splicing, protein localization to P-body, protein localization to nucleus, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome, signal transduction involved in regulation of gene expression; MF: DNA topoisomerase binding, RNA binding, RS domain binding, mRNA binding, nucleic acid binding, protein binding, protein kinase B binding; CC: catalytic step 2 spliceosome, cytoplasm, exon-exon junction complex, nuclear envelope, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Gene expression (Transcription), Herpes simplex virus 1 infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q6PDM2
Entrez ID: 110809
|
Does Knockout of Srp9 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Srp9
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Srp9 (signal recognition particle 9)
Type: protein-coding
Summary: Predicted to enable 7S RNA binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SRP9 (signal recognition particle 9). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, negative regulation of translational elongation; MF: 7S RNA binding, RNA binding; CC: cytoplasm, cytosol, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Mus musculus (mouse), SRP-dependent cotranslational protein targeting to membrane, Translation
UniProt: P49962
Entrez ID: 27058
|
Does Knockout of Orc5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Orc5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Orc5 (origin recognition complex, subunit 5)
Type: protein-coding
Summary: Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and regulation of DNA replication. Predicted to act upstream of or within DNA replication. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; nasal cavity epithelium; and pharyngo-tympanic tube. Orthologous to human ORC5 (origin recognition complex subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA replication, DNA replication initiation, regulation of DNA replication; MF: ATP binding, DNA replication origin binding, nucleotide binding; CC: chromatin, chromosome, cytosol, nuclear origin of replication recognition complex, nucleoplasm, nucleus, origin recognition complex
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the ORC complex at the origin of replication, Assembly of the pre-replicative complex, CDC6 association with the ORC:origin complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: Q9WUV0
Entrez ID: 26429
|
Does Knockout of Eif6 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Eif6
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Eif6 (eukaryotic translation initiation factor 6)
Type: protein-coding
Summary: The protein encoded by this gene is a eukaryotic translation initiation factor that regulates both ribosome biogenesis and translation, which are rate-limiting factors for cell growth. The encoded protein binds 60S ribosomes and prevents their association with 40S ribosomes. This gene may play a role in oncogenesis as well. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: assembly of large subunit precursor of preribosome, cytosolic ribosome assembly, maturation of 5.8S rRNA, maturation of LSU-rRNA, miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated post-transcriptional gene silencing, positive regulation of translation, regulation of fatty acid biosynthetic process, regulation of glycolytic process, regulation of megakaryocyte differentiation, regulation of reactive oxygen species metabolic process, response to insulin, ribosomal large subunit biogenesis, ribosomal subunit export from nucleus, ribosome biogenesis, translation, translational initiation; MF: ribosomal large subunit binding, ribosome binding, translation initiation factor activity; CC: cytoplasm, cytosol, intermediate filament, lamin filament, nucleolus, nucleoplasm, nucleus, synapse
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: O55135
Entrez ID: 16418
|
Does Knockout of Mrpl21 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Mrpl21
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mrpl21 (mitochondrial ribosomal protein L21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D1N9
Entrez ID: 353242
|
Does Knockout of Ncam1 in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 615
|
Knockout
|
Ncam1
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Ncam1 (neural cell adhesion molecule 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonal fasciculation, cell adhesion, cell surface receptor signaling pathway, cellular response to ethanol, commissural neuron axon guidance, epithelial to mesenchymal transition, homotypic cell-cell adhesion, learning or memory, modulation of chemical synaptic transmission, multicellular organismal response to stress, negative regulation of programmed cell death, nervous system development, neuron development, neuron projection development, positive regulation of calcium-mediated signaling, positive regulation of cardiac muscle cell proliferation, regulation of exocyst assembly, regulation of semaphorin-plexin signaling pathway, response to cocaine, response to lead ion, response to xenobiotic stimulus, thalamus development; MF: LRR domain binding, heparin binding, phosphatase binding, protein binding; CC: Schaffer collateral - CA1 synapse, axon, cell surface, cell-cell junction, cytoplasm, cytosol, external side of plasma membrane, glutamatergic synapse, growth cone, membrane, myelin sheath, neuron projection, neuronal cell body, plasma membrane, postsynaptic membrane, presynaptic membrane, side of membrane
Pathways: Axon guidance, Cell adhesion molecules - Mus musculus (mouse), Developmental Biology, L1CAM interactions, MAPK family signaling cascades, MAPK1/MAPK3 signaling, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Prion disease - Mus musculus (mouse), RAF/MAP kinase cascade, Signal Transduction, Signal transduction by L1
UniProt: P13595
Entrez ID: 17967
|
Does Knockout of 9330161L09Rik in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
9330161L09Rik
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: 9330161L09Rik (RIKEN cDNA 9330161L09 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Ebp in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Ebp
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ebp (EBP cholestenol delta-isomerase)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that localizes to the endoplasmic reticulum. This protein catalyses the conversion of delta8 to delta7 sterols, an important step in sterol biosynthesis. Mutations in this gene are responsible for the mouse tattered mutant phenotype. Tattered males are embryonic lethal, while heterozygous females have developmental defects. Deficiency of the related gene in human causes X-linked dominant chondrodysplasia punctata. [provided by RefSeq, May 2015].
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, hemopoiesis, lipid metabolic process, ossification involved in bone maturation, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, sterol metabolic process; MF: C-8 sterol isomerase activity, cholestenol delta-isomerase activity, cholesterol-5,6-oxide hydrolase activity, hydrolase activity, identical protein binding, intramolecular oxidoreductase activity, transposing C=C bonds, isomerase activity, steroid Delta-isomerase activity; CC: cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, nuclear envelope, nuclear membrane, nucleus
Pathways: Cholesterol biosynthesis, Cholesterol biosynthesis via desmosterol, Cholesterol biosynthesis via lathosterol, Metabolism, Metabolism of lipids, Metabolism of steroids, Steroid biosynthesis - Mus musculus (mouse), cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), superpathway of cholesterol biosynthesis
UniProt: P70245
Entrez ID: 13595
|
Does Knockout of Nrxn2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Nrxn2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Nrxn2 (neurexin II)
Type: protein-coding
Summary: Enables several functions, including calcium channel regulator activity; cell adhesion molecule binding activity; and neuroligin family protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; postsynapse organization; and regulation of postsynapse assembly. Acts upstream of or within neurotransmitter secretion and synapse assembly. Part of protein-containing complex. Is active in glutamatergic synapse. Is expressed in several structures, including blood vessel; nervous system; and retina. Used to study autism spectrum disorder. Orthologous to human NRXN2 (neurexin 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: adult behavior, cell adhesion, chemical synaptic transmission, gephyrin clustering involved in postsynaptic density assembly, modulation of chemical synaptic transmission, neuroligin clustering involved in postsynaptic membrane assembly, neurotransmitter secretion, postsynaptic density protein 95 clustering, postsynaptic membrane assembly, presynaptic modulation of chemical synaptic transmission, regulation of biological quality, regulation of postsynapse assembly, signal transduction, social behavior, synapse assembly, vocal learning, vocalization behavior; MF: calcium channel regulator activity, cell adhesion molecule binding, metal ion binding, neuroligin family protein binding, protein binding, transmembrane signaling receptor activity; CC: cell projection, glutamatergic synapse, membrane, plasma membrane, presynaptic membrane, protein-containing complex, synapse
Pathways: Cell adhesion molecules - Mus musculus (mouse), Neurexins and neuroligins, Neuronal System, Protein-protein interactions at synapses
UniProt: E9PUN2, E9Q7X7
Entrez ID: 18190
|
Does Knockout of Stpg4 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Stpg4
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Stpg4 (sperm tail PG rich repeat containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, epigenetic programing of male pronucleus, pyrimidine-containing compound catabolic process; MF: chromatin binding, histone binding, protein binding; CC: cytoplasm, female germ cell nucleus, female pronucleus, germinal vesicle, male germ cell nucleus, male pronucleus, nucleoplasm, nucleus
Pathways:
UniProt: Q9DAG5
Entrez ID: 75467
|
Does Knockout of Gfm2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Gfm2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gfm2 (G elongation factor, mitochondrial 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, ribosome disassembly, translation; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding; CC: mitochondrial matrix, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial translation, Mitochondrial translation termination, Translation
UniProt: Q8R2Q4
Entrez ID: 320806
|
Does Knockout of Slitrk5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Slitrk5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slitrk5 (SLIT and NTRK-like family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult behavior, axonogenesis, chemical synaptic transmission, circulatory system development, dendrite morphogenesis, grooming behavior, positive regulation of synapse assembly, regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission, response to xenobiotic stimulus, skin development, striatum development, synaptic membrane adhesion; CC: glutamatergic synapse, membrane, postsynaptic density membrane, receptor complex, synapse
Pathways: Neuronal System, Protein-protein interactions at synapses, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, Receptor-type tyrosine-protein phosphatases, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q810B7
Entrez ID: 75409
|
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