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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Cyp3a41b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Cyp3a41b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cyp3a41b (cytochrome P450, family 3, subfamily a, polypeptide 41B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alkaloid catabolic process, estrogen metabolic process, lipid hydroxylation, oxidative demethylation, regulation of gene expression, response to bacterium, retinoic acid metabolic process, steroid metabolic process, xenobiotic catabolic process; MF: demethylase activity, estrogen 16-alpha-hydroxylase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, retinoic acid 4-hydroxylase activity, testosterone 6-beta-hydroxylase activity; CC: cellular_component, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Aflatoxin activation and detoxification, Aspirin ADME, Atorvastatin ADME, Biological oxidations, Biosynthesis of DHA-derived SPMs, Biosynthesis of maresin-like SPMs, Biosynthesis of maresins, Biosynthesis of specialized proresolving mediators (SPMs), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cytochrome P450 - arranged by substrate type, Drug ADME, Linoleic acid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Miscellaneous substrates, Phase I - Functionalization of compounds, Prednisone ADME, Retinol metabolism - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), Xenobiotics, bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q9JMA7
Entrez ID: 100041375
|
Does Knockout of Pafah1b1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Pafah1b1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Pafah1b1 (platelet-activating factor acetylhydrolase, isoform 1b, subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acrosome assembly, actin cytoskeleton organization, adult locomotory behavior, ameboidal-type cell migration, auditory receptor cell development, brain morphogenesis, cell differentiation, cell division, cell migration, centrosome localization, cerebral cortex development, cerebral cortex neuron differentiation, chemical synaptic transmission, cochlea development, corpus callosum morphogenesis, cortical microtubule organization, establishment of centrosome localization, establishment of localization in cell, establishment of mitotic spindle orientation, establishment of organelle localization, establishment of planar polarity of embryonic epithelium, forebrain development, germ cell development, hippocampus development, interneuron migration, layer formation in cerebral cortex, learning or memory, lipid catabolic process, lipid metabolic process, maintenance of centrosome location, microtubule cytoskeleton organization, microtubule cytoskeleton organization involved in establishment of planar polarity, microtubule organizing center organization, microtubule sliding, microtubule-based process, modulation of chemical synaptic transmission, myeloid leukocyte migration, negative regulation of JNK cascade, negative regulation of neuron projection development, nervous system development, neuroblast proliferation, neuromuscular process controlling balance, neuron migration, nuclear membrane disassembly, nuclear migration, osteoclast development, positive regulation of axon extension, positive regulation of cellular component organization, positive regulation of cytokine-mediated signaling pathway, positive regulation of dendritic spine morphogenesis, positive regulation of embryonic development, positive regulation of mitotic cell cycle, protein secretion, radial glia-guided pyramidal neuron migration, reelin-mediated signaling pathway, regulation of microtubule cytoskeleton organization, regulation of postsynapse organization, retrograde axonal transport, stem cell division, transmission of nerve impulse, vesicle transport along microtubule; MF: dynein complex binding, dynein intermediate chain binding, identical protein binding, microtubule binding, microtubule plus-end binding, phosphoprotein binding, protein binding, protein heterodimerization activity, protein-containing complex binding; CC: 1-alkyl-2-acetylglycerophosphocholine esterase complex, Schaffer collateral - CA1 synapse, astral microtubule, axon, axon cytoplasm, cell cortex, cell leading edge, central region of growth cone, centrosome, cytoplasm, cytoplasmic microtubule, cytoskeleton, glutamatergic synapse, growth cone, kinesin complex, kinetochore, membrane, microtubule, microtubule associated complex, microtubule cytoskeleton, motile cilium, neuron projection, neuronal cell body, nuclear envelope, nuclear membrane, nucleus, perinuclear region of cytoplasm, spindle, stereocilium, vesicle
Pathways: AURKA Activation by TPX2, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, COPI-independent Golgi-to-ER retrograde traffic, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, EML4 and NUDC in mitotic spindle formation, Ether lipid metabolism - Mus musculus (mouse), G2/M Transition, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Membrane Trafficking, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Organelle biogenesis and maintenance, RHO GTPase Effectors, RHO GTPases Activate Formins, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: P63005
Entrez ID: 18472
|
Does Knockout of Vmn1r38 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Vmn1r38
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Vmn1r38 (vomeronasal 1 receptor 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R2E1
Entrez ID: 171186
|
Does Knockout of Sod2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Sod2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sod2 (superoxide dismutase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure, apoptotic mitochondrial changes, cellular response to ethanol, cellular response to oxidative stress, detection of oxygen, erythrophore differentiation, glutathione metabolic process, heart development, hemopoiesis, hydrogen peroxide biosynthetic process, hydrogen peroxide metabolic process, intracellular oxygen homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to oxidative stress, liver development, locomotory behavior, mitochondrion organization, multicellular organismal-level iron ion homeostasis, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of fat cell differentiation, negative regulation of fibroblast proliferation, negative regulation of membrane hyperpolarization, negative regulation of neuron apoptotic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of vascular associated smooth muscle cell proliferation, neuron development, positive regulation of cell migration, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of nitric oxide biosynthetic process, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching, post-embryonic development, protein homotetramerization, regulation of blood pressure, regulation of mitochondrial membrane potential, regulation of transcription by RNA polymerase II, release of cytochrome c from mitochondria, removal of superoxide radicals, respiratory electron transport chain, response to L-ascorbic acid, response to activity, response to axon injury, response to cadmium ion, response to electrical stimulus, response to gamma radiation, response to hydrogen peroxide, response to hyperoxia, response to hypoxia, response to immobilization stress, response to isolation stress, response to lipopolysaccharide, response to magnetism, response to manganese ion, response to nutrient levels, response to oxidative stress, response to oxygen levels, response to reactive oxygen species, response to selenium ion, response to silicon dioxide, response to superoxide, response to xenobiotic stimulus, response to zinc ion, superoxide anion generation, superoxide metabolic process, vasodilation; MF: DNA binding, enzyme binding, identical protein binding, manganese ion binding, metal ion binding, oxidoreductase activity, oxygen binding, protein binding, superoxide dismutase activity; CC: cytoplasm, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, myelin sheath
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Detoxification of Reactive Oxygen Species, FoxO signaling pathway - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Mitochondrial biogenesis, Organelle biogenesis and maintenance, Peroxisome - Mus musculus (mouse), Transcriptional activation of mitochondrial biogenesis, superoxide radicals degradation
UniProt: P09671
Entrez ID: 20656
|
Does Knockout of Zfp868 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Zfp868
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Zfp868 (zinc finger protein 868)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q3UTQ6
Entrez ID: 234362
|
Does Knockout of Vmn1r171 in Mouse cell causally result in protein/peptide accumulation?
| 1
| 1,047
|
Knockout
|
Vmn1r171
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Vmn1r171 (vomeronasal 1 receptor 171)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: A0A2I3BQT3, Q9EPS6
Entrez ID: 81012
|
Does Knockout of Cog1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Cog1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cog1 (component of oligomeric golgi complex 1)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization; glycosylation; and retrograde transport, vesicle recycling within Golgi. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Predicted to be active in Golgi apparatus. Is expressed in cerebral cortex; cerebral cortex intermediate zone; and cerebral cortex marginal layer. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIg. Orthologous to human COG1 (component of oligomeric golgi complex 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi organization, glycosylation, intra-Golgi vesicle-mediated transport, protein transport, retrograde transport, vesicle recycling within Golgi; CC: Golgi apparatus, Golgi membrane, Golgi transport complex, membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9Z160
Entrez ID: 16834
|
Does Knockout of Ptpn22 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Ptpn22
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ptpn22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, T cell receptor signaling pathway, autophagy, cellular response to muramyl dipeptide, immune system process, lipid metabolic process, lipopolysaccharide-mediated signaling pathway, negative regulation of T cell activation, negative regulation of T cell receptor signaling pathway, negative regulation of autophagy, negative regulation of gene expression, negative regulation of interleukin-6 production, negative regulation of interleukin-8 production, negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, negative regulation of p38MAPK cascade, negative regulation of tumor necrosis factor production, phosphoanandamide dephosphorylation, positive regulation of CD8-positive, alpha-beta T cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of defense response to virus by host, positive regulation of gene expression, positive regulation of granzyme B production, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of protein K63-linked ubiquitination, positive regulation of protein import into nucleus, positive regulation of toll-like receptor 3 signaling pathway, positive regulation of toll-like receptor 4 signaling pathway, positive regulation of toll-like receptor 7 signaling pathway, positive regulation of toll-like receptor 9 signaling pathway, positive regulation of type I interferon production, positive regulation of type II interferon production, protein dephosphorylation, regulation of T cell receptor signaling pathway, regulation of antigen processing and presentation, regulation of calcium ion transmembrane transport, regulation of innate immune response, regulation of leukocyte migration, regulation of natural killer cell proliferation, regulation of non-canonical NF-kappaB signal transduction, response to lipopolysaccharide; MF: SH3 domain binding, hydrolase activity, kinase binding, non-membrane spanning protein tyrosine phosphatase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein tyrosine kinase binding, protein tyrosine phosphatase activity, ubiquitin protein ligase binding; CC: cytoplasm, cytoplasmic side of plasma membrane, nucleus, perinuclear region of cytoplasm
Pathways: Adaptive Immune System, Immune System, Phosphorylation of CD3 and TCR zeta chains, TCR signaling, Translocation of ZAP-70 to Immunological synapse
UniProt: P29352
Entrez ID: 19260
|
Does Knockout of Wdr37 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Wdr37
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Wdr37 (WD repeat domain 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: corpus callosum development, lymphocyte homeostasis; MF: molecular_function, protein binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8CBE3
Entrez ID: 207615
|
Does Knockout of Fmo6 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Fmo6
|
cell cycle progression
|
breast epithelium
|
Gene: Fmo6 (flavin containing monooxygenase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: taurine biosynthetic process, xenobiotic metabolic process; MF: N,N-dimethylaniline monooxygenase activity, NADP binding, flavin adenine dinucleotide binding, monooxygenase activity, oxidoreductase activity; CC: cellular_component, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Drug metabolism - cytochrome P450 - Mus musculus (mouse), nicotine degradation II
UniProt: A0A0J9YUC0, J3QMN6
Entrez ID: 226565
|
Does Knockout of Zc3h13 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Zc3h13
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zc3h13 (zinc finger CCCH type containing 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, regulation of stem cell population maintenance; MF: metal ion binding, zinc ion binding; CC: RNA N6-methyladenosine methyltransferase complex, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: E9Q784
Entrez ID: 67302
|
Does Knockout of Agpat5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Agpat5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Agpat5 (1-acylglycerol-3-phosphate O-acyltransferase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, acylglycerol metabolic process, hematopoietic progenitor cell differentiation, lipid metabolic process, phosphatidylinositol acyl-chain remodeling, phospholipid biosynthetic process; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, acyltransferase activity, transferase activity; CC: endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion, nuclear envelope, nucleolus, nucleus
Pathways: CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Synthesis of PA, phosphatidylglycerol biosynthesis I (plastidic), phosphatidylglycerol biosynthesis II (non-plastidic), phospholipid biosynthesis I, triacylglycerol biosynthesis
UniProt: Q9D1E8
Entrez ID: 52123
|
Does Knockout of Tmco5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Tmco5
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tmco5 (transmembrane and coiled-coil domains 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nucleus
Pathways:
UniProt: Q9D9D5
Entrez ID: 67356
|
Does Knockout of Cxcr3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Cxcr3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cxcr3 (C-X-C motif chemokine receptor 3)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that functions as a receptor for C-X-R chemokines. Signalling through this protein regulates a variety of biological processes, including inflammation, immunity, and would healing. This protein also plays a role in tumor growth and metastasis. [provided by RefSeq, May 2015].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, T cell chemotaxis, adenylate cyclase-activating G protein-coupled receptor signaling pathway, angiogenesis, calcium-mediated signaling, cell chemotaxis, cell surface receptor signaling pathway, chemokine-mediated signaling pathway, chemotaxis, immune response, inflammatory response, negative regulation of angiogenesis, negative regulation of endothelial cell proliferation, negative regulation of execution phase of apoptosis, positive regulation of angiogenesis, positive regulation of cell population proliferation, positive regulation of chemotaxis, positive regulation of cytosolic calcium ion concentration, positive regulation of execution phase of apoptosis, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of transcription by RNA polymerase II, regulation of cell adhesion, regulation of leukocyte migration, signal transduction; MF: C-C chemokine binding, C-C chemokine receptor activity, C-X-C chemokine binding, C-X-C chemokine receptor activity, G protein-coupled receptor activity, chemokine binding, chemokine receptor activity, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: O88410
Entrez ID: 12766
|
Does Knockout of Ints6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Ints6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ints6 (integrator complex subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, protein localization to chromatin, snRNA 3'-end processing, snRNA processing, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: protein-macromolecule adaptor activity; CC: INTAC complex, actin cytoskeleton, chromatin, chromosome, integrator complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q6PCM2
Entrez ID: 18130
|
Does Knockout of Ndufa3 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Ndufa3
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Ndufa3 (NADH:ubiquinone oxidoreductase subunit A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQ91
Entrez ID: 66091
|
Does Knockout of Nelfe in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Nelfe
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nelfe (negative elongation factor complex member E, Rdbp)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of ERK1 and ERK2 cascade, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, transcription pausing by RNA polymerase II; MF: RNA binding, chromatin binding, mRNA binding, nucleic acid binding, protein binding; CC: NELF complex, chromatin, chromosome, nuclear body, nucleoplasm, nucleus, plasma membrane
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: P19426
Entrez ID: 27632
|
Does Knockout of Gpm6a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Gpm6a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gpm6a (glycoprotein m6a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, nervous system development, neural retina development, neuron migration, neuron projection development, neuron projection morphogenesis, positive regulation of filopodium assembly, regulation of synapse organization, response to bacterium, stem cell differentiation, synapse assembly; MF: calcium channel activity; CC: axon, axonal growth cone, cell projection, dendritic spine, filopodium, glutamatergic synapse, growth cone, membrane, neuron projection, neuronal cell body, parallel fiber to Purkinje cell synapse, plasma membrane, presynapse, presynaptic active zone membrane, synapse
Pathways:
UniProt: P35802
Entrez ID: 234267
|
Does Knockout of Stk11 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Stk11
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Stk11 (serine/threonine kinase 11)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: DNA damage response, G1 to G0 transition, Golgi localization, T cell receptor signaling pathway, anoikis, apoptotic process, autophagy, axonogenesis, cell differentiation, cellular response to UV-B, dendrite extension, establishment of cell polarity, glucose homeostasis, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of TORC1 signaling, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of cold-induced thermogenesis, negative regulation of epithelial cell proliferation involved in prostate gland development, positive regulation of autophagy, positive regulation of axonogenesis, positive regulation of gluconeogenesis, positive regulation of protein localization to nucleus, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of vesicle transport along microtubule, positive thymic T cell selection, protein autophosphorylation, protein dephosphorylation, protein phosphorylation, regulation of Wnt signaling pathway, regulation of cell growth, regulation of dendrite morphogenesis, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, response to ionizing radiation, response to lipid, signal transduction, spermatid development, spermatogenesis, tissue homeostasis, vasculature development; MF: ATP binding, LRR domain binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, p53 binding, protein binding, protein kinase activator activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: Z disc, centrosome, cilium, cytoplasm, cytosol, intracellular protein-containing complex, membrane, mitochondrion, nucleoplasm, nucleus, protein-containing complex, serine/threonine protein kinase complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Energy dependent regulation of mTOR by LKB1-AMPK, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Longevity regulating pathway - Mus musculus (mouse), MTOR signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, Tight junction - Mus musculus (mouse), Transcriptional Regulation by TP53, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9WTK7
Entrez ID: 20869
|
Does Knockout of Wdr44 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Wdr44
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Wdr44 (WD repeat domain 44)
Type: protein-coding
Summary: This gene encodes a protein containing multiple WD repeats. The encoded protein may play a role in vesicle trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: Golgi to plasma membrane protein transport, cytosolic ciliogenesis, negative regulation of cilium assembly, positive regulation of cilium assembly, protein localization to cilium, regulation of cell migration, regulation of vesicle-mediated transport; MF: molecular sequestering activity, small GTPase binding; CC: Golgi apparatus, cytoplasm, cytosol, endosome, endosome membrane, membrane, microtubule, perinuclear region of cytoplasm
Pathways:
UniProt: Q6NVE8
Entrez ID: 72404
|
Does Knockout of Trim32 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Trim32
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Trim32 (tripartite motif-containing 32)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin ubiquitination, autophagosome assembly, axon development, cellular homeostasis, cellular response to amino acid starvation, cellular response to stress, cilium assembly, cytosolic ciliogenesis, fat cell differentiation, free ubiquitin chain polymerization, innate immune response, muscle cell cellular homeostasis, negative regulation of cilium assembly, negative regulation of fibroblast proliferation, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of keratinocyte apoptotic process, negative regulation of toll-like receptor 4 signaling pathway, negative regulation of viral transcription, positive regulation of DNA-templated transcription, positive regulation of autophagosome assembly, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of catabolic process, positive regulation of cell cycle, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell motility, positive regulation of chemokine (C-C motif) ligand 20 production, positive regulation of interleukin-17-mediated signaling pathway, positive regulation of macromolecule biosynthetic process, positive regulation of neurogenesis, positive regulation of neuron differentiation, positive regulation of protein catabolic process, positive regulation of protein metabolic process, positive regulation of proteolysis, positive regulation of signal transduction, positive regulation of striated muscle cell differentiation, positive regulation of tumor necrosis factor-mediated signaling pathway, protein K63-linked ubiquitination, protein localization to phagocytic vesicle, protein polyubiquitination, protein ubiquitination, response to UV, response to oxidative stress, response to starvation, response to tumor necrosis factor, suppression of viral release by host, tissue homeostasis, toll-like receptor 4 signaling pathway, ubiquitin-dependent protein catabolic process; MF: RNA binding, identical protein binding, metal ion binding, myosin binding, protein binding, protein-macromolecule adaptor activity, transcription coactivator activity, transferase activity, translation initiation factor binding, ubiquitin binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: autophagosome, centrosome, cytoplasm, nucleus, striated muscle myosin thick filament
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Cytosolic sensors of pathogen-associated DNA , Immune System, Innate Immune System, Regulation of innate immune responses to cytosolic DNA, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8CH72
Entrez ID: 69807
|
Does Knockout of Rpp25l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Rpp25l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rpp25l (ribonuclease P/MRP 25 subunit-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: nucleus, ribonuclease MRP complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q99JH1
Entrez ID: 69961
|
Does Knockout of Rnaseh2b in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Rnaseh2b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rnaseh2b (ribonuclease H2, subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, in utero embryonic development, mismatch repair, negative regulation of gene expression, nucleobase-containing compound metabolic process, positive regulation of fibroblast proliferation, regulation of DNA damage checkpoint, regulation of G2/M transition of mitotic cell cycle, ribonucleotide metabolic process; CC: nucleoplasm, nucleus, ribonuclease H2 complex
Pathways: DNA replication - Mus musculus (mouse)
UniProt: Q80ZV0
Entrez ID: 67153
|
Does Knockout of Prc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Prc1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Prc1 (protein regulator of cytokinesis 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule cytoskeleton organization, mitotic spindle midzone assembly, positive regulation of cell population proliferation, regulation of cytokinesis; MF: identical protein binding, kinesin binding, microtubule binding, protein kinase binding; CC: contractile ring, cytoplasm, cytoskeleton, intercellular bridge, microtubule, microtubule cytoskeleton, midbody, mitotic spindle midzone, nucleoplasm, nucleus, plasma membrane, spindle, spindle pole
Pathways: RHO GTPase Effectors, RHO GTPases activate CIT, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q99K43
Entrez ID: 233406
|
Does Knockout of Mastl in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Mastl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mastl (microtubule associated serine/threonine kinase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, G2/M transition of mitotic cell cycle, cell division, female meiosis II, intracellular signal transduction, meiotic cell cycle, mitotic cell cycle, regulation of cell cycle, regulation of mitotic cell cycle; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein phosphatase 2A binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, transmembrane transporter binding; CC: centrosome, cleavage furrow, cytoplasm, cytoskeleton, microtubule cytoskeleton, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, M Phase, MASTL Facilitates Mitotic Progression, Mitotic Prophase
UniProt: Q8C0P0
Entrez ID: 67121
|
Does Knockout of S100a14 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
S100a14
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: S100a14 (S100 calcium binding protein A14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, defense response to bacterium, positive regulation of granulocyte chemotaxis, positive regulation of monocyte chemotaxis, response to lipopolysaccharide, toll-like receptor 4 signaling pathway; MF: calcium ion binding, calcium-dependent protein binding, chemokine receptor binding; CC: cytoplasm, extracellular space, perinuclear region of cytoplasm
Pathways:
UniProt: Q9D2Q8
Entrez ID: 66166
|
Does Knockout of Tsc2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 2,173
|
Knockout
|
Tsc2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tsc2 (TSC complex subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import, TORC1 signaling, anoikis, cell projection organization, cellular response to insulin stimulus, cellular response to nutrient levels, cellular response to starvation, connective tissue replacement, cytoplasmic translation, establishment of cell polarity, excitatory chemical synaptic transmission, heart development, inhibitory chemical synaptic transmission, intracellular protein localization, kidney development, myofibroblast differentiation, negative regulation of B cell proliferation, negative regulation of T cell proliferation, negative regulation of TOR signaling, negative regulation of TORC1 signaling, negative regulation of Wnt signaling pathway, negative regulation of axonogenesis, negative regulation of cell population proliferation, negative regulation of cell size, negative regulation of epithelial cell proliferation, negative regulation of epithelial to mesenchymal transition, negative regulation of fibroblast proliferation, negative regulation of insulin receptor signaling pathway, negative regulation of macroautophagy, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of pinocytosis, negative regulation of translational initiation, negative regulation of vascular endothelial cell proliferation, neural tube closure, positive chemotaxis, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of cell adhesion, positive regulation of dendritic spine development, positive regulation of fibroblast migration, positive regulation of insulin receptor signaling pathway, positive regulation of macroautophagy, positive regulation of neuron projection development, positive regulation of transcription by RNA polymerase II, positive regulation of translational initiation, protein import into nucleus, protein localization to cell surface, protein transport into plasma membrane raft, proximal tubule development, regulation of cell cycle, regulation of endocytosis, regulation of insulin receptor signaling pathway, regulation of macroautophagy, regulation of postsynapse organization, regulation of small GTPase mediated signal transduction, response to hypoxia, social behavior, tissue remodeling; MF: 14-3-3 protein binding, GTPase activator activity, Hsp90 protein binding, phosphatase binding, protein binding, protein homodimerization activity, protein-containing complex binding, small GTPase binding; CC: Golgi apparatus, TSC1-TSC2 complex, caveola, cell projection, cytoplasm, cytosol, dendrite, glutamatergic synapse, growth cone, lysosomal membrane, lysosome, membrane, neuronal cell body, nucleus, perinuclear region of cytoplasm, postsynaptic density, synapse
Pathways: AMPK signaling pathway - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: Q3UHB2, Q7TT21, Q3TQ10, A0A2I3BRT5, Q3UGI8, A0A2I3BPP1, Q3UG88, A0A2I3BPR7, A0A2I3BRA1, A0A2I3BPE9
Entrez ID: 22084
|
Does Knockout of Cnot4 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Cnot4
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Cnot4 (CCR4-NOT transcription complex, subunit 4)
Type: protein-coding
Summary: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein autoubiquitination; regulation of megakaryocyte differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT complex. Is expressed in several structures, including central nervous system; genitourinary system; neural retina; and olfactory epithelium. Orthologous to human CNOT4 (CCR4-NOT transcription complex subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: protein autoubiquitination, protein ubiquitination, regulation of megakaryocyte differentiation, ubiquitin-dependent protein catabolic process; MF: RNA binding, metal ion binding, nucleic acid binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: CCR4-NOT complex, cytoplasm, cytosol, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Polymerase II Transcription, RNA degradation - Mus musculus (mouse), TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: Q8BT14
Entrez ID: 53621
|
Does Knockout of Mettl6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Mettl6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mettl6 (methyltransferase 6, methylcytidine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, tRNA methylation, tRNA modification, tRNA processing; MF: enzyme binding, methyltransferase activity, tRNA (cytidine-3-)-methyltransferase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8BVH9
Entrez ID: 67011
|
Does Knockout of Crlf2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Crlf2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Crlf2 (cytokine receptor-like factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, inflammatory response, positive regulation of cell population proliferation, positive regulation of interleukin-5 production, positive regulation of mast cell activation, positive regulation of receptor signaling pathway via STAT; MF: coreceptor activity, cytokine activity, cytokine receptor activity, protein binding; CC: external side of plasma membrane, extracellular region, membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse)
UniProt: Q8CII9
Entrez ID: 57914
|
Does Knockout of Atf4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Atf4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Atf4 (activating transcription factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GDF15-GFRAL signaling pathway, HRI-mediated signaling, L-asparagine metabolic process, PERK-mediated unfolded protein response, bone mineralization, cellular response to amino acid starvation, cellular response to glucose starvation, cellular response to hypoxia, cellular response to leucine starvation, cellular response to oxidative stress, circadian regulation of gene expression, circadian rhythm, embryonic hemopoiesis, endoplasmic reticulum unfolded protein response, gamma-aminobutyric acid signaling pathway, gene expression, gluconeogenesis, integrated stress response signaling, intracellular calcium ion homeostasis, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, lens fiber cell morphogenesis, mRNA transcription by RNA polymerase II, mitochondrial respirasome assembly, negative regulation of cold-induced thermogenesis, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of potassium ion transport, negative regulation of transcription by RNA polymerase II, neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of biomineral tissue development, positive regulation of gene expression, positive regulation of neuron apoptotic process, positive regulation of sodium-dependent phosphate transport, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular endothelial growth factor production, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of osteoblast differentiation, regulation of synaptic plasticity, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to manganese-induced endoplasmic reticulum stress, response to nutrient levels, response to toxic substance, rhythmic process; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding, cAMP response element binding protein binding, general transcription initiation factor binding, identical protein binding, leucine zipper domain binding, promoter-specific chromatin binding, protein binding, protein heterodimerization activity, protein kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: ATF1-ATF4 transcription factor complex, ATF4-CREB1 transcription factor complex, CHOP-ATF4 complex, Lewy body core, RNA polymerase II transcription regulator complex, centrosome, cytoplasm, cytoskeleton, dendrite membrane, membrane, mitochondrion, neuron projection, nuclear periphery, nuclear speck, nucleoplasm, nucleus, plasma membrane, protein-containing complex, transcription regulator complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q06507
Entrez ID: 11911
|
Does Knockout of Cul3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Cul3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cul3 (cullin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII vesicle coating, RNA polymerase II transcription initiation surveillance, Wnt signaling pathway, anaphase-promoting complex-dependent catabolic process, apoptotic process, cell division, cell migration, cell morphogenesis, cell projection organization, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to insulin stimulus, cellular response to nutrient levels, cellular response to oxidative stress, embryonic cleavage, endoplasmic reticulum to Golgi vesicle-mediated transport, fibroblast apoptotic process, gastrulation, gene expression, in utero embryonic development, inflammatory response, integrin-mediated signaling pathway, kidney development, liver morphogenesis, mitotic cell cycle, mitotic metaphase chromosome alignment, negative regulation of Rho protein signal transduction, negative regulation of TORC1 signaling, negative regulation of macromolecule biosynthetic process, negative regulation of transcription by RNA polymerase II, negative regulation of type I interferon production, nuclear protein quality control by the ubiquitin-proteasome system, positive regulation of TORC1 signaling, positive regulation of cytokinesis, positive regulation of mitotic cell cycle phase transition, positive regulation of mitotic metaphase/anaphase transition, positive regulation of protein ubiquitination, positive regulation of type I interferon production, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein autoubiquitination, protein catabolic process, protein destabilization, protein monoubiquitination, protein polyubiquitination, protein quality control for misfolded or incompletely synthesized proteins, protein ubiquitination, regulation of cellular response to insulin stimulus, regulation of gene expression, regulation of primary metabolic process, regulation of transcription by RNA polymerase II, regulation protein catabolic process at postsynapse, renal sodium ion absorption, response to oxidative stress, response to stress, signal transduction, stem cell division, stress fiber assembly, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, trophectodermal cellular morphogenesis, type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, vesicle-mediated transport; MF: Notch binding, POZ domain binding, cyclin binding, identical protein binding, protein binding, ubiquitin ligase complex scaffold activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity; CC: Cul3-RING ubiquitin ligase complex, Golgi apparatus, cell projection, centrosome, cilium, cullin-RING ubiquitin ligase complex, cytoplasm, cytoskeleton, glutamatergic synapse, mitotic spindle, motile cilium, nucleus, plasma membrane, polar microtubule, postsynapse, sperm flagellum, spindle, spindle pole
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Degradation of DVL, Hedgehog 'on' state, Hedgehog signaling pathway - Mus musculus (mouse), Immune System, KEAP1-NFE2L2 pathway, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Metabolism of proteins, Neddylation, Post-translational protein modification, RAF/MAP kinase cascade, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, RHOBTB2 GTPase cycle, RHOBTB3 ATPase cycle, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of RAS by GAPs, Regulation of T cell activation by CD28 family, SPOP-mediated proteasomal degradation of PD-L1(CD274), Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, TCF dependent signaling in response to WNT, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9JLV5
Entrez ID: 26554
|
Does Knockout of Pcdha1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Pcdha1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcdha1 (protocadherin alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: endoplasmic reticulum, membrane, plasma membrane
Pathways:
UniProt: Q641K6, Q91Y21
Entrez ID: 116731
|
Does Knockout of Mrps25 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Mrps25
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mrps25 (mitochondrial ribosomal protein S25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D125
Entrez ID: 64658
|
Does Knockout of Sptlc1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Sptlc1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sptlc1 (serine palmitoyltransferase, long chain base subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, lipid metabolic process, positive regulation of lipophagy, regulation of fat cell apoptotic process, sphinganine biosynthetic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingomyelin biosynthetic process, sphingosine biosynthetic process; MF: acyltransferase activity, protein binding, pyridoxal phosphate binding, serine C-palmitoyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, serine palmitoyltransferase complex
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), ceramide biosynthesis
UniProt: O35704
Entrez ID: 268656
|
Does Knockout of Srxn1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Srxn1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Srxn1 (sulfiredoxin 1 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular oxidant detoxification, cellular response to oxidative stress, response to oxidative stress; MF: ATP binding, antioxidant activity, nucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, sulfiredoxin activity; CC: cytoplasm, cytosol
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, KEAP1-NFE2L2 pathway, NFE2L2 regulating anti-oxidant/detoxification enzymes, Nuclear events mediated by NFE2L2
UniProt: Q9D975
Entrez ID: 76650
|
Does Knockout of Slc35e1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Slc35e1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slc35e1 (solute carrier family 35, member E1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, membrane
Pathways:
UniProt: Q8CD26
Entrez ID: 270066
|
Does Knockout of Ttc28 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Ttc28
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Ttc28 (tetratricopeptide repeat domain 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, regulation of mitotic cell cycle; CC: centrosome, cytoplasm, cytoskeleton, midbody, mitotic spindle, mitotic spindle midzone, mitotic spindle pole, spindle, spindle pole
Pathways:
UniProt: Q80XJ3
Entrez ID: 209683
|
Does Knockout of Fhit in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Fhit
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fhit (fragile histidine triad gene)
Type: protein-coding
Summary: This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very fragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: DNA replication, apoptotic process, diadenosine triphosphate catabolic process, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, purine nucleotide metabolic process; MF: adenosine 5'-monophosphoramidase activity, adenylylsulfatase activity, adenylylsulfate-ammonia adenylyltransferase activity, bis(5'-adenosyl)-triphosphatase activity, catalytic activity, hydrolase activity, identical protein binding, nickel cation binding, nucleotide binding, transferase activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, fibrillar center, mitochondrion, nucleus, plasma membrane
Pathways: Non-small cell lung cancer - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse)
UniProt: O89106
Entrez ID: 14198
|
Does Knockout of Eapp in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Eapp
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Eapp (E2F-associated phosphoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription elongation by RNA polymerase II, positive regulation of cell population proliferation, positive regulation of transcription elongation by RNA polymerase II; CC: cytoplasm, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q5BU09
Entrez ID: 66266
|
Does Knockout of Gm4131 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Gm4131
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gm4131 (predicted gene 4131)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A140LJ24
Entrez ID: 100042960
|
Does Knockout of Kri1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Kri1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Kri1 (KRI1 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: 90S preribosome, nucleolus
Pathways:
UniProt: V9GXJ9, F6WIU1
Entrez ID: 215194
|
Does Knockout of Lrrc23 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Lrrc23
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lrrc23 (leucine rich repeat containing 23)
Type: protein-coding
Summary: Involved in flagellated sperm motility and radial spoke assembly. Located in sperm flagellum. Is active in cytosol. Is expressed in lung; lung epithelium; nasal cavity respiratory epithelium; nasal epithelium; and palatal shelf mesenchyme. Human ortholog(s) of this gene implicated in spermatogenic failure 92. Orthologous to human LRRC23 (leucine rich repeat containing 23). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, flagellated sperm motility, radial spoke assembly; MF: molecular_function, protein binding; CC: cell projection, cilium, cytoplasm, cytoskeleton, cytosol, motile cilium, sperm flagellum
Pathways:
UniProt: O35125
Entrez ID: 16977
|
Does Knockout of Magt1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Magt1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Magt1 (magnesium transporter 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cognition, magnesium ion transmembrane transport, magnesium ion transport, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex B, plasma membrane
Pathways: Adaptive Immune System, Co-inhibition by PD-1, Immune System, Innate Immune System, Miscellaneous transport and binding events, Neutrophil degranulation, PD-L1(CD274) glycosylation and translocation to plasma membrane, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Transport of small molecules
UniProt: Q9CQY5
Entrez ID: 67075
|
Does Knockout of Ndufa3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ndufa3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ndufa3 (NADH:ubiquinone oxidoreductase subunit A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQ91
Entrez ID: 66091
|
Does Knockout of Rapgef4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Rapgef4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rapgef4 (Rap guanine nucleotide exchange factor (GEF) 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Ras protein signal transduction, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, calcium-ion regulated exocytosis, exocytosis, hormone secretion, insulin secretion, intracellular signal transduction, negative regulation of synaptic transmission, positive regulation of insulin secretion, positive regulation of neuronal action potential, positive regulation of protein secretion, positive regulation of smooth muscle cell migration, regulation of dendrite development, regulation of exocytosis, regulation of insulin secretion, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, regulation of postsynapse organization, regulation of synaptic vesicle cycle, small GTPase-mediated signal transduction; MF: cAMP binding, guanyl-nucleotide exchange factor activity, nucleotide binding, protein binding, protein-containing complex binding, protein-macromolecule adaptor activity, small GTPase binding; CC: apical plasma membrane, axon, basolateral plasma membrane, brush border, cone cell pedicle, cytoplasm, cytosol, dendrite, dendritic spine, excitatory synapse, glutamatergic synapse, growth cone, hippocampal mossy fiber to CA3 synapse, membrane, neuronal cell body, photoreceptor inner segment, photoreceptor outer segment, plasma membrane, postsynaptic density, presynapse, protein-containing complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q9EQZ6
Entrez ID: 56508
|
Does Knockout of Dlgap3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Dlgap3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dlgap3 (DLG associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: modification of postsynaptic structure, modulation of chemical synaptic transmission, protein-containing complex assembly, signaling; MF: PDZ domain binding, amyloid-beta binding, molecular adaptor activity, protein domain specific binding, scaffold protein binding; CC: cholinergic synapse, dendritic spine, glutamatergic synapse, membrane, neuromuscular junction, neuronal cell body, plasma membrane, postsynaptic density, postsynaptic specialization, synapse
Pathways: Neurexins and neuroligins, Neuronal System, Protein-protein interactions at synapses
UniProt: Q6PFD5
Entrez ID: 242667
|
Does Knockout of Ccdc115 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Ccdc115
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccdc115 (coiled-coil domain containing 115)
Type: protein-coding
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in cellular response to increased oxygen levels; intracellular monoatomic cation homeostasis; and lysosomal protein catabolic process. Located in lysosome. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spinal cord. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIo. Orthologous to human CCDC115 (coiled-coil domain containing 115). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to increased oxygen levels, intracellular iron ion homeostasis, lysosomal lumen acidification, lysosomal protein catabolic process, vacuolar proton-transporting V-type ATPase complex assembly; CC: COPI-coated vesicle, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, endosome, lysosome, vacuolar proton-transporting V-type ATPase complex, vacuole
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8VE99
Entrez ID: 69668
|
Does Knockout of Usp36 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Usp36
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Usp36 (ubiquitin specific peptidase 36)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of macroautophagy, nucleolus organization, protein deubiquitination, protein stabilization, proteolysis, regulation of apoptotic process, regulation of protein stability, regulation of rRNA processing; MF: K48-linked deubiquitinase activity, RNA binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2B deubiquitinase activity, hydrolase activity, peptidase activity, transferase activity; CC: cytoplasm, cytosol, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: B1AQJ2
Entrez ID: 72344
|
Does Knockout of Bet1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Bet1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Bet1 (Bet1 golgi vesicular membrane trafficking protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, syntaxin binding; CC: Golgi apparatus, Golgi cis cisterna, Golgi cisterna, Golgi membrane, SNARE complex, cis-Golgi network, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O35623
Entrez ID: 12068
|
Does Knockout of Osbpl9 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Osbpl9
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Osbpl9 (oxysterol binding protein-like 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: lipid binding, sterol binding; CC: Golgi apparatus, cytosol, endosome, late endosome membrane, membrane
Pathways: Bile acid and bile salt metabolism, Metabolism, Metabolism of lipids, Metabolism of steroids, Synthesis of bile acids and bile salts
UniProt: A2A8Z1
Entrez ID: 100273
|
Does Knockout of Brca2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Brca2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Brca2 (breast cancer 2, early onset)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA recombination, DNA repair, brain development, cell population proliferation, cellular response to ionizing radiation, cellular senescence, centrosome duplication, chordate embryonic development, chromatin remodeling, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, establishment of protein localization to telomere, female gonad development, hematopoietic stem cell proliferation, hemopoiesis, homologous chromosome orientation in meiotic metaphase I, inner cell mass cell proliferation, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, male meiosis I, mammary gland development, meiosis I, mitotic recombination-dependent replication fork processing, multicellular organism growth, negative regulation of mammary gland epithelial cell proliferation, nucleotide-excision repair, oocyte maturation, positive regulation of DNA-templated transcription, positive regulation of mitotic cell cycle, regulation of DNA damage checkpoint, regulation of DNA-templated transcription, regulation of cytokinesis, replication fork processing, response to UV-C, response to X-ray, response to gamma radiation, spermatogenesis, stem cell proliferation, telomere maintenance via recombination; MF: DNA binding, gamma-tubulin binding, histone H3 acetyltransferase activity, histone H4 acetyltransferase activity, identical protein binding, protease binding, protein binding, single-stranded DNA binding; CC: BRCA2-MAGE-D1 complex, DNA repair complex, centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytoskeleton, cytosol, lateral element, nuclear ubiquitin ligase complex, nucleoplasm, nucleus, protein-containing complex, secretory granule
Pathways: Breast cancer - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through MMEJ (alt-NHEJ), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Presynaptic phase of homologous DNA pairing and strand exchange, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: P97929
Entrez ID: 12190
|
Does Knockout of Zmynd10 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Zmynd10
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zmynd10 (zinc finger, MYND domain containing 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium movement, inner dynein arm assembly, motile cilium assembly, outer dynein arm assembly, positive regulation of motile cilium assembly, protein folding, protein localization to cilium; MF: metal ion binding, molecular adaptor activity, protein binding, protein folding chaperone, zinc ion binding; CC: apical plasma membrane, centriolar satellite, cytoplasm, cytoskeleton, dynein axonemal particle, membrane, plasma membrane
Pathways:
UniProt: Q99ML0
Entrez ID: 114602
|
Does Knockout of Uba5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Uba5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Uba5 (ubiquitin-like modifier activating enzyme 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: erythrocyte differentiation, megakaryocyte differentiation, neuromuscular process, protein K69-linked ufmylation, protein ufmylation, regulation of intracellular estrogen receptor signaling pathway, regulation of type II interferon production, response to endoplasmic reticulum stress, reticulophagy; MF: ATP binding, UFM1 activating enzyme activity, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, ubiquitin-like modifier activating enzyme activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q8VE47
Entrez ID: 66663
|
Does Knockout of Ndufb11 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ndufb11
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ndufb11 (NADH:ubiquinone oxidoreductase subunit B11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: O09111
Entrez ID: 104130
|
Does Knockout of Mcm4 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Mcm4
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Mcm4 (minichromosome maintenance complex component 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA replication initiation, DNA strand elongation involved in DNA replication, double-strand break repair via break-induced replication, mitotic DNA replication initiation, premeiotic DNA replication; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: CMG complex, MCM complex, chromosome, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, DNA replication - Mus musculus (mouse), G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: P49717
Entrez ID: 17217
|
Does Knockout of Rab35 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Rab35
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rab35 (RAB35, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rab protein signal transduction, antigen processing and presentation, cellular response to nerve growth factor stimulus, endocytic recycling, endosomal transport, intracellular protein localization, mitotic cytokinesis, neuron projection development, plasma membrane to endosome transport, protein localization to endosome, protein transport; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: cell projection membrane, clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle, cytoplasmic vesicle, endosome, endosome membrane, intercellular bridge, melanosome, membrane, mitochondrion, plasma membrane, synaptic vesicle membrane
Pathways: Endocytosis - Mus musculus (mouse), Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q6PHN9
Entrez ID: 77407
|
Does Knockout of Spop in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Spop
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Spop (speckle-type BTB/POZ protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucose homeostasis, negative regulation of transcription by RNA polymerase II, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of type B pancreatic cell apoptotic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of proteolysis, ubiquitin-dependent protein catabolic process; MF: RNA polymerase II-specific DNA-binding transcription factor binding, identical protein binding, molecular function inhibitor activity, protein binding, ubiquitin protein ligase binding; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, nuclear speck, nucleus
Pathways: Adaptive Immune System, Co-inhibition by PD-1, Hedgehog 'on' state, Hedgehog signaling pathway - Mus musculus (mouse), Immune System, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SPOP-mediated proteasomal degradation of PD-L1(CD274), Signal Transduction, Signaling by Hedgehog
UniProt: Q6ZWS8
Entrez ID: 20747
|
Does Knockout of Gngt1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Gngt1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gngt1 (guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cardiac muscle cell apoptotic process, cellular response to hypoxia, eye photoreceptor cell development, intracellular protein localization, phototransduction, signal transduction; MF: G-protein beta-subunit binding, GTPase activity; CC: heterotrimeric G-protein complex, membrane, photoreceptor inner segment, photoreceptor outer segment, plasma membrane
Pathways: ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of G protein gated Potassium channels, Activation of GABAB receptors, Activation of kainate receptors upon glutamate binding, Activation of the phototransduction cascade, Adrenaline,noradrenaline inhibits insulin secretion, Alcoholism - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Aquaporin-mediated transport, Beta-catenin independent WNT signaling, Ca2+ pathway, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chaperonin-mediated protein folding, Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Class B/2 (Secretin family receptors), Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Dopaminergic synapse - Mus musculus (mouse), ESR-mediated signaling, Extra-nuclear estrogen signaling, G alpha (12/13) signalling events, G alpha (i) signalling events, G alpha (q) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G beta:gamma signalling through BTK, G beta:gamma signalling through CDC42, G beta:gamma signalling through PI3Kgamma, G beta:gamma signalling through PLC beta, G protein gated Potassium channels, G-protein activation, G-protein beta:gamma signalling, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Mus musculus (mouse), GPCR downstream signalling, GPCR ligand binding, GPER1 signaling, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Glutamatergic synapse - Mus musculus (mouse), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Inactivation, recovery and regulation of the phototransduction cascade, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Integration of energy metabolism, Inwardly rectifying K+ channels, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Metabolism, Metabolism of proteins, Morphine addiction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phototransduction - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet homeostasis, Potassium Channels, Presynaptic function of Kainate receptors, Prostacyclin signalling through prostacyclin receptor, Protein folding, Ras signaling pathway - Mus musculus (mouse), Regulation of insulin secretion, Relaxin signaling pathway - Mus musculus (mouse), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Mus musculus (mouse), Sensory Perception, Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by WNT, The phototransduction cascade, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, Transmission across Chemical Synapses, Transport of small molecules, Vasopressin regulates renal water homeostasis via Aquaporins, Visual phototransduction
UniProt: Q61012
Entrez ID: 14699
|
Does Knockout of Cox7b in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Cox7b
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Cox7b (cytochrome c oxidase subunit 7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: central nervous system development, mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, aerobic respiration -- electron donor II
UniProt: P56393
Entrez ID: 66142
|
Does Knockout of Cyld in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Cyld
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cyld (CYLD lysine 63 deubiquitinase)
Type: protein-coding
Summary: This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment, Wnt signaling pathway, canonical NF-kappaB signal transduction, defense response to bacterium, homeostasis of number of cells, immune system process, innate immune response, necroptotic process, negative regulation of JNK cascade, negative regulation of NF-kappaB transcription factor activity, negative regulation of canonical NF-kappaB signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of inflammatory response, negative regulation of interleukin-18-mediated signaling pathway, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of p38MAPK cascade, positive regulation of T cell differentiation, positive regulation of T cell receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of protein localization, protein K63-linked deubiquitination, protein deubiquitination, protein linear deubiquitination, proteolysis, regulation of B cell differentiation, regulation of cilium assembly, regulation of inflammatory response, regulation of intrinsic apoptotic signaling pathway, regulation of microtubule cytoskeleton organization, regulation of mitotic cell cycle, regulation of necroptotic process, regulation of tumor necrosis factor-mediated signaling pathway, ripoptosome assembly involved in necroptotic process; MF: K48-linked deubiquitinase activity, K63-linked deubiquitinase activity, Met1-linked polyubiquitin deubiquitinase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, proline-rich region binding, protein binding, protein kinase binding, zinc ion binding; CC: cell projection, centriolar satellite, centrosome, ciliary basal body, ciliary tip, cytoplasm, cytoplasmic microtubule, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, glutamatergic synapse, membrane, microtubule, midbody, nucleoplasm, organelle, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, spindle
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), DDX58/IFIH1-mediated induction of interferon-alpha/beta, Death Receptor Signaling, Deubiquitination, Immune System, Innate Immune System, Metabolism of proteins, NF-kappa B signaling pathway - Mus musculus (mouse), NOD1/2 Signaling Pathway, Necroptosis - Mus musculus (mouse), Negative regulators of DDX58/IFIH1 signaling, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Osteoclast differentiation - Mus musculus (mouse), Post-translational protein modification, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of TNFR1 signaling, Signal Transduction, TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR1-induced proapoptotic signaling, Ub-specific processing proteases
UniProt: Q80TQ2
Entrez ID: 74256
|
Does Knockout of Znhit2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Znhit2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Znhit2 (zinc finger, HIT domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, zinc ion binding
Pathways:
UniProt: Q9QY66
Entrez ID: 29805
|
Does Knockout of 5031410I06Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
5031410I06Rik
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: 5031410I06Rik (RIKEN cDNA 5031410I06 gene)
Type: protein-coding
Summary: RIKEN cDNA 5031410I06 gene
Gene Ontology:
Pathways:
UniProt: E9Q4E0
Entrez ID: 381622
|
Does Knockout of Ogfr in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Ogfr
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ogfr (opioid growth factor receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: opioid growth factor receptor activity, signaling receptor activity; CC: cytoplasm, membrane, nucleus
Pathways:
UniProt: Q99PG2
Entrez ID: 72075
|
Does Knockout of Arpc2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Arpc2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Arpc2 (actin related protein 2/3 complex, subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin filament polymerization, cellular response to epidermal growth factor stimulus, cellular response to platelet-derived growth factor stimulus, cellular response to rapamycin, intracellular signal transduction, positive regulation of actin filament polymerization, positive regulation of barbed-end actin filament capping, positive regulation of filopodium assembly, positive regulation of lamellipodium assembly, positive regulation of podosome assembly, positive regulation of protein targeting to membrane, positive regulation of protein-containing complex assembly, positive regulation of smooth muscle cell migration, positive regulation of substrate adhesion-dependent cell spreading, regulation of actin cytoskeleton organization, regulation of actin filament polymerization; MF: ATPase binding, actin binding, actin filament binding, glutamate receptor binding, protein binding, protein-containing complex binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, Schaffer collateral - CA1 synapse, actin cytoskeleton, actin filament branch point, apical dendrite, axon terminus, cell leading edge, cell projection, cell surface, concave side of sperm head, cytoplasm, cytoskeleton, dendritic shaft, dendritic spine, endosome, filamentous actin, focal adhesion, glutamatergic synapse, growth cone, lamellipodium, muscle cell projection membrane, neuron projection, nucleoplasm, nucleus, perikaryon, peripheral region of growth cone, plasma membrane, podosome core, podosome ring, postsynapse, presynapse, ruffle membrane, secretory granule, site of double-strand break, synapse, synaptic vesicle membrane, ventral surface of cell
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Membrane Trafficking, Nervous system development, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: Q9CVB6
Entrez ID: 76709
|
Does Knockout of Arhgef25 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Arhgef25
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Arhgef25 (Rho guanine nucleotide exchange factor 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, protein binding; CC: cytoplasm, extrinsic component of membrane, membrane, myofibril, plasma membrane, sarcomere
Pathways: CDC42 GTPase cycle, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, G alpha (q) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p75 NTR receptor-mediated signalling
UniProt: Q9CWR0
Entrez ID: 52666
|
Does Knockout of Lingo4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Lingo4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Lingo4 (leucine rich repeat and Ig domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of synapse assembly, regulation of nervous system development; MF: molecular_function, signaling receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q149C3
Entrez ID: 320747
|
Does Knockout of Dpcd in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Dpcd
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dpcd (deleted in primary ciliary dyskinesia)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: determination of left/right symmetry, epithelial cilium movement involved in extracellular fluid movement, establishment of localization in cell, flagellated sperm motility, lateral ventricle development, left/right pattern formation, spermatogenesis, third ventricle development, ventricular system development
Pathways:
UniProt: Q8BPA8
Entrez ID: 226162
|
Does Knockout of Clec3b in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Clec3b
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Clec3b (C-type lectin domain family 3, member b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, ossification, positive regulation of plasminogen activation, skeletal system development; MF: calcium ion binding, carbohydrate binding, heparin binding, kringle domain binding, protein binding; CC: cytoplasm, extracellular matrix, extracellular region, extracellular space, granular component
Pathways:
UniProt: Q8CFZ6
Entrez ID: 21922
|
Does Knockout of Kcns2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Kcns2
|
response to virus
|
Microglial Cell Line
|
Gene: Kcns2 (K+ voltage-gated channel, subfamily S, 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of potassium ion transmembrane transport, transmembrane transport; MF: monoatomic ion channel activity, potassium channel activity, potassium channel regulator activity, voltage-gated potassium channel activity; CC: membrane, monoatomic ion channel complex, perinuclear region of cytoplasm, plasma membrane, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: O35174
Entrez ID: 16539
|
Does Knockout of Sh3tc2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Sh3tc2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sh3tc2 (SH3 domain and tetratricopeptide repeats 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: myelination in peripheral nervous system, peripheral nervous system myelin maintenance, regulation of ERBB signaling pathway, regulation of endocytic recycling, regulation of intracellular protein transport; CC: cytoplasmic vesicle, plasma membrane, recycling endosome
Pathways:
UniProt: Q80VA5
Entrez ID: 225608
|
Does Knockout of Htr2c in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Htr2c
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Htr2c (5-hydroxytryptamine (serotonin) receptor 2C)
Type: protein-coding
Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor signaling pathway, behavioral fear response, behavioral response to nicotine, cGMP-mediated signaling, chemical synaptic transmission, feeding behavior, intracellular calcium ion homeostasis, locomotory behavior, negative regulation of dopamine metabolic process, phospholipase C-activating G protein-coupled receptor signaling pathway, phospholipase C-activating serotonin receptor signaling pathway, phospholipase D-activating G protein-coupled receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of acetylcholine secretion, neurotransmission, positive regulation of calcium-mediated signaling, positive regulation of fat cell differentiation, positive regulation of gamma-aminobutyric acid secretion, positive regulation of phosphatidylinositol biosynthetic process, positive regulation of vasoconstriction, regulation of appetite, regulation of corticotropin-releasing hormone secretion, regulation of nervous system process, release of sequestered calcium ion into cytosol, response to xenobiotic stimulus, sensitization, serotonin receptor signaling pathway, signal transduction; MF: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, Gq/11-coupled serotonin receptor activity, identical protein binding, neurotransmitter receptor activity, protein binding, serotonin binding, serotonin receptor activity; CC: G protein-coupled serotonin receptor complex, cell surface, dendrite, external side of plasma membrane, membrane, plasma membrane, synapse
Pathways: Amine ligand-binding receptors, Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Gap junction - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Serotonin receptors, Signal Transduction, Signaling by GPCR
UniProt: P34968
Entrez ID: 15560
|
Does Knockout of Tgif1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Tgif1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tgif1 (TGFB-induced factor homeobox 1)
Type: protein-coding
Summary: Enables chromatin binding activity. Acts upstream of or within several processes, including negative regulation of retinoic acid receptor signaling pathway; positive regulation of amacrine cell differentiation; and regionalization. Located in nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo ectoderm; and genitourinary system. Used to study otitis media. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Orthologous to human TGIF1 (TGFB induced factor homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: amacrine cell differentiation, cellular response to growth factor stimulus, determination of left/right symmetry, dorsal/ventral pattern formation, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of retinoic acid receptor signaling pathway, negative regulation of transcription by RNA polymerase II, neural tube closure, nodal signaling pathway, positive regulation of amacrine cell differentiation, positive regulation of fibroblast proliferation, regulation of DNA-templated transcription, regulation of gastrulation, response to xenobiotic stimulus, retina development in camera-type eye; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, JUN kinase binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, co-SMAD binding, protein binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways: Downregulation of SMAD2/3:SMAD4 transcriptional activity, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta signaling pathway - Mus musculus (mouse), Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
UniProt: P70284
Entrez ID: 21815
|
Does Knockout of Eva1c in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Eva1c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Eva1c (eva-1 homolog C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, heparin binding, molecular_function; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: P58659
Entrez ID: 70967
|
Does Knockout of C1qa in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
C1qa
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: C1qa (complement component 1, q subcomponent, alpha polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: astrocyte activation, complement activation, classical pathway, complement-mediated synapse pruning, immune system process, innate immune response, microglial cell activation, neuron remodeling, synapse organization, synapse pruning, vertebrate eye-specific patterning; MF: IgG binding, IgM binding, metal ion binding, phosphatidylserine binding, protein binding; CC: cell surface, collagen trimer, complement component C1 complex, complement component C1q complex, extracellular region, extracellular space, extrinsic component of postsynaptic membrane, extrinsic component of presynaptic membrane, glutamatergic synapse, postsynapse, symbiont cell surface, synapse
Pathways: Alcoholic liver disease - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Classical antibody-mediated complement activation, Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Coronavirus disease - COVID-19 - Mus musculus (mouse), Creation of C4 and C2 activators, Immune System, Initial triggering of complement, Innate Immune System, Pertussis - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Regulation of Complement cascade, Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse)
UniProt: P98086
Entrez ID: 12259
|
Does Knockout of Rnd1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Rnd1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Rnd1 (Rho family GTPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, negative regulation of cell adhesion, neuron remodeling, regulation of actin cytoskeleton organization, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein kinase binding, signaling receptor binding; CC: actin cytoskeleton, adherens junction, cytoplasm, cytoskeleton, cytosol, membrane, plasma membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, Nervous system development, RHO GTPase cycle, RND1 GTPase cycle, Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Sema4D mediated inhibition of cell attachment and migration, Semaphorin interactions, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BLR7
Entrez ID: 223881
|
Does Knockout of Rpap3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Rpap3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rpap3 (RNA polymerase II associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: R2TP complex, RPAP3/R2TP/prefoldin-like complex, ciliary basal body, cilium, cytosol, protein folding chaperone complex
Pathways:
UniProt: Q9D706
Entrez ID: 71919
|
Does Knockout of Cpsf1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Cpsf1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cpsf1 (cleavage and polyadenylation specific factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, mRNA processing; MF: RNA binding, enzyme binding, mRNA 3'-UTR AU-rich region binding, nucleic acid binding; CC: mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9EPU4
Entrez ID: 94230
|
Does Knockout of Gphb5 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Gphb5
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Gphb5 (glycoprotein hormone beta 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of thyroid hormone receptor signaling pathway; MF: hormone activity, protein heterodimerization activity, thyrotropin-releasing hormone receptor binding; CC: cytoplasm, extracellular region, extracellular space
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Hormone ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q812B2
Entrez ID: 217674
|
Does Knockout of Slc2a9 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Slc2a9
|
cell proliferation
|
Regulatory T cell
|
Gene: Slc2a9 (solute carrier family 2 (facilitated glucose transporter), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import, D-glucose transmembrane transport, dehydroascorbic acid transport, fructose transmembrane transport, transmembrane transport, urate metabolic process, urate transport; MF: D-glucose transmembrane transporter activity, fructose transmembrane transporter activity, transmembrane transporter activity, urate transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, nuclear envelope, plasma membrane
Pathways: Cellular hexose transport, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q3T9X0
Entrez ID: 117591
|
Does Knockout of Map3k4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Map3k4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Map3k4 (mitogen-activated protein kinase kinase kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, chorionic trophoblast cell differentiation, determination of dorsal identity, intracellular signal transduction, male germ-line sex determination, p38MAPK cascade, placenta development, positive regulation of JUN kinase activity, positive regulation of p38MAPK cascade, positive regulation of telomere maintenance, regulation of gene expression, response to UV-C; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, perinuclear region of cytoplasm
Pathways: GnRH signaling pathway - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse)
UniProt: O08648
Entrez ID: 26407
|
Does Knockout of Cacna2d1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Cacna2d1
|
response to virus
|
Microglial Cell Line
|
Gene: Cacna2d1 (calcium channel, voltage-dependent, alpha2/delta subunit 1)
Type: protein-coding
Summary: This gene encodes a regulatory component of the voltage-dependent calcium channel complex. The product of this gene is a proprotein that is proteolytically processed into alpha-2 and delta subunits, which are linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transmembrane transport via high voltage-gated calcium channel, calcium ion transport, calcium ion transport into cytosol, cardiac muscle cell action potential involved in contraction, cellular response to amyloid-beta, membrane depolarization during bundle of His cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, regulation of calcium ion transport, regulation of heart rate by cardiac conduction, regulation of membrane repolarization during action potential, regulation of ventricular cardiac muscle cell membrane repolarization; MF: calcium channel activity, metal ion binding, protein binding, voltage-gated calcium channel activity, voltage-gated calcium channel activity involved in bundle of His cell action potential; CC: GABA-ergic synapse, L-type voltage-gated calcium channel complex, T-tubule, glutamatergic synapse, membrane, monoatomic ion channel complex, neuronal dense core vesicle, plasma membrane, postsynaptic membrane, presynaptic active zone membrane, sarcoplasmic reticulum, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse)
UniProt: O08532
Entrez ID: 12293
|
Does Knockout of Fkrp in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Fkrp
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fkrp (fukutin related protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult walking behavior, basement membrane organization, bone mineralization, brain development, camera-type eye development, central nervous system development, connective tissue development, connective tissue replacement, creatine metabolic process, diaphragm development, extracellular matrix organization, eye development, filtration diaphragm assembly, gene expression, glial cell differentiation, glycolytic process, glycoprotein biosynthetic process, glycoprotein metabolic process, heart development, heart morphogenesis, in utero embryonic development, inflammatory response, intracellular protein localization, lipid metabolic process, localization of cell, maintenance of protein localization in endoplasmic reticulum, muscle cell differentiation, muscle contraction, muscle structure development, neuromuscular process, neuron migration, oxygen metabolic process, pentitol metabolic process, pentose metabolic process, phosphatidylinositol 3-kinase/protein kinase B signal transduction, protein O-linked glycosylation via mannose, protein glycosylation, protein import, protein processing, protein tetramerization, reelin-mediated signaling pathway, respiratory system process, response to activity, response to alcohol, response to glucocorticoid, response to xenobiotic stimulus, skeletal muscle fiber differentiation, skeletal muscle organ development, skeletal muscle tissue development, skeletal muscle tissue regeneration, striated muscle cell differentiation; MF: dystroglycan binding, identical protein binding, laminin binding, metal ion binding, phosphotransferase activity, for other substituted phosphate groups, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endoplasmic reticulum, extracellular region, extracellular space, membrane, nucleoplasm, plasma membrane, rough endoplasmic reticulum, sarcolemma, skeletal muscle myofibril
Pathways: DAG1 glycosylations, Mannose type O-glycan biosynthesis - Mus musculus (mouse), Matriglycan biosynthesis on DAG1, Metabolism of proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8CG64
Entrez ID: 243853
|
Does Knockout of Stx3 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Stx3
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Stx3 (syntaxin 3)
Type: protein-coding
Summary: Predicted to enable SNAP receptor activity; SNARE binding activity; and arachidonate binding activity. Involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane; modulation of chemical synaptic transmission; and vesicle-mediated transport in synapse. Acts upstream of or within exocytosis and long-term synaptic potentiation. Located in several cellular components, including cytoplasmic vesicle; photoreceptor inner segment; and photoreceptor outer segment. Part of SNARE complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human STX3 (syntaxin 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: exocytic insertion of neurotransmitter receptor to postsynaptic membrane, exocytosis, intracellular protein transport, long-term synaptic potentiation, membrane fusion, modulation of chemical synaptic transmission, neuron projection development, neurotransmitter transport, organelle membrane fusion, positive regulation of cell adhesion, positive regulation of cell population proliferation, positive regulation of chemotaxis, positive regulation of protein localization to cell surface, positive regulation of protein localization to plasma membrane, regulation of gene expression, vesicle docking, vesicle fusion, vesicle-mediated transport, vesicle-mediated transport in synapse; MF: SNAP receptor activity, SNARE binding, arachidonate binding, protein binding; CC: SNARE complex, Schaffer collateral - CA1 synapse, apical plasma membrane, azurophil granule, cell projection, cell-cell junction, dendrite, endomembrane system, glutamatergic synapse, growth cone, lamellipodium, melanosome, membrane, neuron projection, photoreceptor cell terminal bouton, photoreceptor inner segment, photoreceptor outer segment, plasma membrane, plasma membrane bounded cell projection, postsynapse, presynapse, presynaptic membrane, ribbon synapse, secretory granule, specific granule, synaptic vesicle, zymogen granule membrane
Pathways: Cytokine Signaling in Immune system, Immune System, Other interleukin signaling, SNARE interactions in vesicular transport - Mus musculus (mouse), Signaling by Interleukins, Synaptic vesicle cycle - Mus musculus (mouse)
UniProt: Q64704
Entrez ID: 20908
|
Does Knockout of Gm20791 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gm20791
|
phagocytosis
|
macrophage
|
Gene: Gm20791 (Y-linked testis-specific protein 1-like)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 108168617
|
Does Knockout of Numbl in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Numbl
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Numbl (numb-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adherens junction organization, axonogenesis, cytokine-mediated signaling pathway, forebrain development, lateral ventricle development, nervous system development, neuroblast division in subventricular zone, neuroblast proliferation, positive regulation of dendrite morphogenesis, positive regulation of neurogenesis, protein metabolic process, regulation of postsynapse assembly; CC: cytoplasm, glutamatergic synapse
Pathways: Notch signaling pathway - Mus musculus (mouse)
UniProt: O08919
Entrez ID: 18223
|
Does Knockout of Atad3a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Atad3a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atad3a (ATPase family, AAA domain containing 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, HRI-mediated signaling, PERK-mediated unfolded protein response, antiviral innate immune response, mitochondrion organization, negative regulation of PERK-mediated unfolded protein response, negative regulation of apoptotic process, regulation of cell growth, translational initiation; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding, protein serine/threonine kinase inhibitor activity; CC: membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrion
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q925I1
Entrez ID: 108888
|
Does Knockout of G6pd2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
G6pd2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: G6pd2 (glucose-6-phosphate dehydrogenase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NADP+ metabolic process, NADPH regeneration, cellular response to oxidative stress, cholesterol biosynthetic process, erythrocyte maturation, glucose 6-phosphate metabolic process, glucose metabolic process, glutathione metabolic process, negative regulation of cell growth involved in cardiac muscle cell development, negative regulation of reactive oxygen species metabolic process, pentose biosynthetic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch, positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, regulation of neuron apoptotic process, response to ethanol, ribose phosphate biosynthetic process; MF: D-glucose binding, NADP binding, carbohydrate binding, glucose-6-phosphate dehydrogenase activity, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors, protein homodimerization activity; CC: centriolar satellite, cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Glutathione metabolism - Mus musculus (mouse), Pentose phosphate pathway - Mus musculus (mouse), formaldehyde oxidation I, pentose phosphate pathway, pentose phosphate pathway (oxidative branch)
UniProt: P97324
Entrez ID: 14380
|
Does Knockout of Ankrd23 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Ankrd23
|
cell cycle progression
|
breast epithelium
|
Gene: Ankrd23 (ankyrin repeat domain 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid metabolic process, positive regulation of transcription by RNA polymerase II, regulation of sarcomere organization, response to mechanical stimulus, response to muscle stretch; MF: titin binding, transcription cis-regulatory region binding; CC: I band, actin cytoskeleton, cytosol, intercalated disc, myofibril, nucleoplasm, nucleus
Pathways:
UniProt: Q812A3
Entrez ID: 78321
|
Does Knockout of Cdkl1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Cdkl1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Cdkl1 (cyclin dependent kinase like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heart development, regulation of cell cycle, regulation of cilium assembly; MF: ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: ciliary transition zone, cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q8CEQ0
Entrez ID: 71091
|
Does Knockout of Cep170 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Cep170
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cep170 (centrosomal protein 170)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein binding; CC: centriolar subdistal appendage, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, microtubule, spindle
Pathways:
UniProt: Q6A065
Entrez ID: 545389
|
Does Knockout of Larp4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Larp4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Larp4 (La ribonucleoprotein 4)
Type: protein-coding
Summary: Predicted to enable mRNA 3'-UTR binding activity and poly(A) binding activity. Predicted to be involved in cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human LARP4 (La ribonucleoprotein 4). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cytoskeleton organization, positive regulation of translation, post-transcriptional regulation of gene expression, regulation of cell morphogenesis, translation; MF: RNA binding, mRNA 3'-UTR binding, nucleic acid binding, poly(A) binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, cytosolic small ribosomal subunit
Pathways:
UniProt: Q8BWW4
Entrez ID: 207214
|
Does Knockout of Cldn24 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Cldn24
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cldn24 (claudin 24)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the human homolog. Similar to the human gene, this gene is upstream of the Cldn22 gene, which overlaps the Wwc2 gene on the opposite strand. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: bicellular tight junction assembly, cell adhesion; MF: molecular_function, structural molecule activity; CC: anchoring junction, apical plasma membrane, bicellular tight junction, membrane, plasma membrane, tight junction
Pathways: Cell adhesion molecules - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: D3YXJ9
Entrez ID: 100039801
|
Does Knockout of Gjd4 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Gjd4
|
cell cycle progression
|
breast epithelium
|
Gene: Gjd4 (gap junction protein, delta 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell communication, cell-cell signaling, regulation of satellite cell activation involved in skeletal muscle regeneration, transmembrane transport; CC: anchoring junction, connexin complex, gap junction, membrane, plasma membrane
Pathways: Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q8BSD4
Entrez ID: 225152
|
Does Knockout of Tmem147 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Tmem147
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmem147 (transmembrane protein 147)
Type: protein-coding
Summary: Predicted to enable ribosome binding activity. Predicted to be involved in multi-pass transmembrane protein insertion into ER membrane and protein localization to nuclear inner membrane. Predicted to be located in nuclear membrane and plasma membrane. Predicted to be part of multi-pass translocon complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in genitourinary system. Orthologous to human TMEM147 (transmembrane protein 147). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: multi-pass transmembrane protein insertion into ER membrane, protein localization to nuclear inner membrane; MF: ribosome binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, multi-pass translocon complex, nuclear membrane, nucleus, plasma membrane, protein-containing complex
Pathways:
UniProt: Q9CQG6
Entrez ID: 69804
|
Does Knockout of Ssxb5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Ssxb5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ssxb5 (SSX member B5)
Type: protein-coding
Summary: Predicted to be located in sperm flagellum. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 5 and synovial sarcoma. Orthologous to several human genes including SSX1 (SSX family member 1); SSX2 (SSX family member 2); and SSX2B (SSX family member 2B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: nucleus, sperm flagellum
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q6XAS2
Entrez ID: 387586
|
Does Knockout of Creld2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Creld2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Creld2 (cysteine-rich with EGF-like domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, extracellular matrix structural constituent, isomerase activity, molecular_function, protein disulfide isomerase activity; CC: Golgi apparatus, endoplasmic reticulum, extracellular space
Pathways:
UniProt: Q9CYA0
Entrez ID: 76737
|
Does Knockout of Gnb1l in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Gnb1l
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gnb1l (guanine nucleotide binding protein (G protein), beta polypeptide 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, social behavior; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9EQ15
Entrez ID: 13972
|
Does Knockout of Rho in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Rho
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rho (rhodopsin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled opsin signaling pathway, G protein-coupled receptor signaling pathway, absorption of visible light, cellular response to light stimulus, detection of light stimulus, detection of temperature stimulus involved in thermoception, gene expression, microtubule cytoskeleton organization, photoreceptor cell maintenance, phototransduction, podosome assembly, red, far-red light phototransduction, response to light intensity, response to light stimulus, retina development in camera-type eye, rod bipolar cell differentiation, sensory perception of light stimulus, signal transduction, thermotaxis, visual perception; MF: 11-cis retinal binding, G protein-coupled photoreceptor activity, G protein-coupled receptor activity, metal ion binding, photoreceptor activity, protein binding, retinal binding, spectrin binding; CC: Golgi apparatus, cell projection, cell-cell junction, membrane, photoreceptor disc membrane, photoreceptor inner segment, photoreceptor inner segment membrane, photoreceptor outer segment, photoreceptor outer segment membrane, plasma membrane, rod photoreceptor outer segment, rough endoplasmic reticulum membrane, sperm head plasma membrane, sperm midpiece
Pathways: Activation of the phototransduction cascade, Cargo trafficking to the periciliary membrane, Cilium Assembly, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Inactivation, recovery and regulation of the phototransduction cascade, Opsins, Organelle biogenesis and maintenance, Phototransduction - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by GPCR, The canonical retinoid cycle in rods (twilight vision), The phototransduction cascade, Visual phototransduction, VxPx cargo-targeting to cilium
UniProt: P15409
Entrez ID: 212541
|
Does Knockout of Eloa in Pancreatic Cell Line causally result in cell proliferation?
| 1
| 2,192
|
Knockout
|
Eloa
|
cell proliferation
|
Pancreatic Cell Line
|
Gene: Eloa (elongin A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter; CC: elongin complex, nucleoplasm, nucleus, site of DNA damage, transcription elongation factor complex
Pathways: Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q8CB77
Entrez ID: 27224
|
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