prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Tshb in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Tshb
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tshb (thyroid stimulating hormone, beta subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, extracellular region, extracellular space
Pathways: Autoimmune thyroid disease - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: E9Q4F3
Entrez ID: 22094
|
Does Knockout of Dqx1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Dqx1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dqx1 (DEAQ RNA-dependent ATPase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, RNA binding, helicase activity, nucleotide binding; CC: nucleus, spliceosomal complex
Pathways:
UniProt: Q924H9
Entrez ID: 93838
|
Does Knockout of Hmgxb3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Hmgxb3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hmgxb3 (HMG box domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: Q6NZP6, Q6AXF8, G3X9M3, Q8R168, Q8BY57, Q9JJ64, Q6PEF4, A0A494B973, A0A494B9M0
Entrez ID: 106894
|
Does Knockout of Eif3d in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Eif3d
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eif3d (eukaryotic translation initiation factor 3, subunit D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRES-dependent viral translational initiation, cap-dependent translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation, viral translational termination-reinitiation; MF: RNA binding, mRNA cap binding, translation initiation factor activity; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: O70194
Entrez ID: 55944
|
Does Knockout of Dek in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Dek
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dek (DEK proto-oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, regulation of double-strand break repair, regulation of double-strand break repair via nonhomologous end joining; MF: DNA binding, histone binding; CC: B-WICH complex, contractile muscle fiber, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Positive epigenetic regulation of rRNA expression, RNA Polymerase II Transcription, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
UniProt: Q7TNV0
Entrez ID: 110052
|
Does Knockout of Emp2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Emp2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Emp2 (epithelial membrane protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell mediated cytotoxicity, actin filament organization, actin-mediated cell contraction, apoptotic process, bleb assembly, blood vessel endothelial cell migration, caveola assembly, cell adhesion, cell-matrix adhesion, early endosome to late endosome transport, embryo implantation, embryonic process involved in female pregnancy, heart formation, membrane raft assembly, natural killer cell proliferation, neutrophil migration, plasma membrane raft assembly, positive regulation of angiogenesis, positive regulation of cardiac epithelial to mesenchymal transition, positive regulation of cell population proliferation, positive regulation of cell-matrix adhesion, positive regulation of integrin-mediated signaling pathway, protein localization to cell surface, protein localization to plasma membrane, regulation of angiogenesis, regulation of cell-matrix adhesion, regulation of endothelial cell migration, regulation of glomerular filtration, regulation of kinase activity, regulation of vasculogenesis; MF: integrin binding, kinase binding; CC: Golgi apparatus, Golgi membrane, apical part of cell, apical plasma membrane, caveola, cell surface, cytoplasm, cytoplasmic vesicle, membrane, membrane raft, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: O88662
Entrez ID: 13731
|
Does Knockout of Pdcl in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Pdcl
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pdcl (phosducin-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, heterotrimeric G-protein complex assembly, negative regulation of protein refolding, positive regulation of smoothened signaling pathway, protein folding, regulation of G protein-coupled receptor signaling pathway, visual perception; CC: cell projection, cilium, cytoplasm
Pathways: Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: Q9DBX2
Entrez ID: 67466
|
Does Knockout of Zcchc24 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Zcchc24
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zcchc24 (zinc finger, CCHC domain containing 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, nucleic acid binding, zinc ion binding
Pathways:
UniProt: B2RVL6
Entrez ID: 71918
|
Does Knockout of Crlf2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Crlf2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Crlf2 (cytokine receptor-like factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, inflammatory response, positive regulation of cell population proliferation, positive regulation of interleukin-5 production, positive regulation of mast cell activation, positive regulation of receptor signaling pathway via STAT; MF: coreceptor activity, cytokine activity, cytokine receptor activity, protein binding; CC: external side of plasma membrane, extracellular region, membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse)
UniProt: Q8CII9
Entrez ID: 57914
|
Does Knockout of Spag4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Spag4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Spag4 (sperm associated antigen 4)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in microtubule. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. Is expressed in brainstem; genitourinary system; submandibular gland; and trachea. Orthologous to human SPAG4 (sperm associated antigen 4). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell differentiation, spermatogenesis; MF: identical protein binding, protein-membrane adaptor activity; CC: cell projection, cilium, cytoplasm, cytoskeleton, meiotic nuclear membrane microtubule tethering complex, membrane, microtubule, motile cilium, nuclear envelope, nuclear inner membrane, nucleus
Pathways:
UniProt: Q9JJF2
Entrez ID: 245865
|
Does Knockout of Dusp28 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Dusp28
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Dusp28 (dual specificity phosphatase 28)
Type: protein-coding
Summary: Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation. Orthologous to human DUSP28 (dual specificity phosphatase 28). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity
Pathways:
UniProt: Q8BTR5
Entrez ID: 67446
|
Does Knockout of Enpp1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Enpp1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Enpp1 (ectonucleotide pyrophosphatase/phosphodiesterase 1)
Type: protein-coding
Summary: This gene encodes a member of the nucleoside pyrophosphatase/phosphodiesterase family of enzymes that catalyzes the hydrolysis of pyrophosphate and phosphodiester bonds in nucleotide triphosphates and oligonucleotides, respectively, to generate nucleoside 5'-monophosphates. The encoded protein is a type II transmembrane glycoprotein that negatively regulates bone mineralization. Mice harboring a nonsense mutation in this gene, termed tiptoe walking (ttw), exhibit ectopic ossification of the spinal ligaments. The encoded protein binds to the insulin receptor, inhibits downstream signaling events and induces insulin resistance and glucose tolerance. This gene is located adjacent to a paralog on chromosome 10. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate metabolic process, ATP metabolic process, B-1 B cell homeostasis, D-glucose import, T cell differentiation, Wnt signaling pathway, adipose tissue development, adult locomotory behavior, adult walking behavior, animal organ development, aorta development, apoptotic process involved in development, artery development, articular cartilage development, axon regeneration, biomineral tissue development, bone development, bone growth, bone mineralization, bone mineralization involved in bone maturation, bone remodeling, bone resorption, bone trabecula formation, calcium ion homeostasis, cartilage development, cell morphogenesis, cell population proliferation, cellular homeostasis, cellular response to insulin stimulus, cellular response to sodium phosphate, cementum mineralization, central nervous system myelination, coenzyme A catabolic process, collagen-activated signaling pathway, defense response to protozoan, determination of adult lifespan, diphosphate metabolic process, endochondral bone morphogenesis, endochondral ossification, establishment of localization in cell, fat cell differentiation, fat pad development, fatty acid metabolic process, fibroblast growth factor receptor signaling pathway, gene expression, generation of precursor metabolites and energy, glucose homeostasis, glycolytic process, heart development, hematopoietic stem cell migration to bone marrow, hormone metabolic process, immune response, inflammatory response to antigenic stimulus, inhibition of non-skeletal tissue mineralization, inorganic diphosphate transport, intracellular phosphate ion homeostasis, kidney development, leukocyte activation involved in inflammatory response, ligamentous ossification, long-term synaptic potentiation, mRNA transcription by RNA polymerase II, macrophage differentiation, magnesium ion homeostasis, melanocyte differentiation, microglia differentiation, microglial cell migration, middle ear morphogenesis, mitochondrion organization, morphogenesis of an epithelium, mucus secretion, multicellular organism growth, muscle cell cellular homeostasis, negative regulation of D-glucose import, negative regulation of bone mineralization, negative regulation of cell growth, negative regulation of fat cell differentiation, negative regulation of glycogen biosynthetic process, negative regulation of hh target transcription factor activity, negative regulation of insulin receptor signaling pathway, negative regulation of ossification, neuron apoptotic process, nucleoside triphosphate catabolic process, odontogenesis, oligodendrocyte apoptotic process, organic phosphonate metabolic process, ossification, osteoblast differentiation, osteoclast differentiation, phosphate ion homeostasis, phosphate-containing compound metabolic process, plasma cell differentiation, post-embryonic forelimb morphogenesis, protein poly-ADP-ribosylation, regulation of bone mineralization, response to ATP, response to Gram-positive bacterium, response to dietary excess, response to insulin, response to magnesium ion, response to platelet-derived growth factor, response to sodium phosphate, response to vitamin B6, response to wounding, sensory perception of mechanical stimulus, sensory perception of sound, sensory perception of temperature stimulus, skin development, smoothened signaling pathway, spinal cord development, tooth mineralization, vascular associated smooth muscle cell migration, vascular associated smooth muscle cell proliferation, vasculogenesis, vesicle-mediated transport, vitamin D3 metabolic process; MF: 3',5'-cyclic-AMP phosphodiesterase activity, ATP binding, ATP diphosphatase activity, GTP diphosphatase activity, UTP diphosphatase activity, calcium ion binding, coenzyme A diphosphatase activity, cyclic-GMP-AMP hydrolase activity, dinucleotide phosphatase activity, exonuclease activity, hydrolase activity, identical protein binding, insulin receptor binding, metal ion binding, nucleic acid binding, nucleoside triphosphate diphosphatase activity, phosphatase activity, phosphodiesterase I activity, phosphoric diester hydrolase activity, polysaccharide binding, protein homodimerization activity, pyrophosphatase activity, scavenger receptor activity, zinc ion binding; CC: apical dendrite, basal dendrite, basolateral plasma membrane, cell body, cell projection, cell surface, extracellular region, extracellular space, membrane, neuronal cell body, plasma membrane
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Pantothenate and CoA biosynthesis - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), Riboflavin metabolism - Mus musculus (mouse), Starch and sucrose metabolism - Mus musculus (mouse), Vitamin B2 (riboflavin) metabolism, riboflavin, FMN and FAD transformations
UniProt: P06802
Entrez ID: 18605
|
Does Knockout of Sipa1l2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Sipa1l2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sipa1l2 (signal-induced proliferation-associated 1 like 2)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Involved in presynaptic signal transduction. Is active in glutamatergic synapse. Is expressed in brain and thymus primordium. Orthologous to human SIPA1L2 (signal induced proliferation associated 1 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: presynaptic signal transduction, regulation of small GTPase mediated signal transduction; MF: GTPase activator activity; CC: cytoplasm, glutamatergic synapse, postsynaptic density, intracellular component, presynapse
Pathways: Rap1 signaling pathway - Mus musculus (mouse)
UniProt: Q80TE4
Entrez ID: 244668
|
Does Knockout of Eif3f in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Eif3f
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eif3f (eukaryotic translation initiation factor 3, subunit F)
Type: protein-coding
Summary: Enables cysteine-type deubiquitinase activity and translation initiation factor binding activity. Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in synapse. Is expressed in several structures, including central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 67. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: IRES-dependent viral translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, proteolysis, translation, translational initiation; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, identical protein binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, protein binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q9DCH4
Entrez ID: 66085
|
Does Knockout of Coq9 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Coq9
|
cell cycle progression
|
breast epithelium
|
Gene: Coq9 (coenzyme Q9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, NADH to ubiquinone, ubiquinone biosynthetic process; MF: enzyme activator activity, isoprenoid binding, lipid binding, protein homodimerization activity; CC: mitochondrial inner membrane, mitochondrion, ubiquinone biosynthesis complex
Pathways: Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Ubiquinol biosynthesis
UniProt: Q8K1Z0
Entrez ID: 67914
|
Does Knockout of Chd8 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Chd8
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Chd8 (chromodomain helicase DNA binding protein 8)
Type: protein-coding
Summary: This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which is common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. In mammals, this gene has been shown to function in several processes including transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Knockout of this gene causes early embryonic lethality due to widespread apoptosis. Heterozygous loss of function mutations result in autism spectrum disorder-like behaviors that include increased anxiety, repetitive behavior, and altered social behavior. [provided by RefSeq, Dec 2016].
Gene Ontology: BP: Wnt signaling pathway, brain development, chromatin organization, chromatin remodeling, digestive tract development, in utero embryonic development, long-term memory, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of Wnt signaling pathway, negative regulation of apoptotic process, negative regulation of canonical Wnt signaling pathway, negative regulation of fibroblast apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, prepulse inhibition, regulation of gene expression, social behavior, startle response; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent chromatin remodeler activity, DNA binding, DNA helicase activity, armadillo repeat domain binding, beta-catenin binding, chromatin binding, histone H3K4me3 reader activity, histone binding, hydrolase activity, nucleotide binding, p53 binding, protein binding; CC: MLL1 complex, chromatin, nucleoplasm, nucleus, protein-containing complex
Pathways: Deactivation of the beta-catenin transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q09XV5
Entrez ID: 67772
|
Does Knockout of Fxn in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Fxn
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fxn (frataxin)
Type: protein-coding
Summary: Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; ferroxidase activity; and iron ion binding activity. Involved in [4Fe-4S] cluster assembly. Acts upstream of or within several processes, including adult walking behavior; muscle cell cellular homeostasis; and negative regulation of organ growth. Located in mitochondrion. Part of mitochondrial [2Fe-2S] assembly complex. Is expressed in several structures, including brain; cartilage condensation; heart; hemolymphoid system; and lower jaw incisor. Used to study Friedreich ataxia. Human ortholog(s) of this gene implicated in Friedreich ataxia; Friedreich ataxia 1; glioblastoma; and type 2 diabetes mellitus. Orthologous to human FXN (frataxin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: [2Fe-2S] cluster assembly, [4Fe-4S] cluster assembly, adult walking behavior, aerobic respiration, cellular response to hydrogen peroxide, embryo development ending in birth or egg hatching, heme biosynthetic process, inorganic ion homeostasis, intracellular iron ion homeostasis, intracellular monoatomic cation homeostasis, iron import into the mitochondrion, iron ion transport, iron-sulfur cluster assembly, mitochondrion organization, monoatomic ion transport, muscle cell cellular homeostasis, negative regulation of apoptotic process, negative regulation of lipid storage, negative regulation of multicellular organism growth, negative regulation of neuron apoptotic process, negative regulation of organ growth, negative regulation of release of cytochrome c from mitochondria, oxidative phosphorylation, positive regulation of axon extension, positive regulation of mitochondrial membrane permeability, proprioception, protein autoprocessing, protein maturation, regulation of cytosolic calcium ion concentration, regulation of growth, response to iron ion; MF: 2 iron, 2 sulfur cluster binding, enzyme activator activity, enzyme binding, ferric iron binding, ferrous iron binding, ferroxidase activity, iron chaperone activity, metal ion binding, oxidoreductase activity; CC: cytoplasm, cytosol, iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Complex III assembly, Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Mitochondrial protein import, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), Protein localization, Respiratory electron transport
UniProt: O35943
Entrez ID: 14297
|
Does Knockout of Efcab6 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Efcab6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Efcab6 (EF-hand calcium binding domain 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, flagellated sperm motility; MF: calcium ion binding, metal ion binding, molecular_function; CC: axonemal A tubule inner sheath, cell projection, cilium, cytoplasm, cytoskeleton, motile cilium, nucleoplasm, nucleus, sperm flagellum
Pathways:
UniProt: Q6P1E8
Entrez ID: 77627
|
Does Knockout of Pnpla5 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Pnpla5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pnpla5 (patatin-like phospholipase domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid catabolic process, lipid homeostasis, lipid metabolic process, triglyceride catabolic process; MF: hydrolase activity, triacylglycerol lipase activity; CC: cytoplasm, lipid droplet, membrane
Pathways: Metabolism, Metabolism of lipids, Triglyceride catabolism, Triglyceride metabolism
UniProt: Q32LZ8
Entrez ID: 75772
|
Does Knockout of Fbxo43 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Fbxo43
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fbxo43 (F-box protein 43)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiotic cell cycle, meiotic nuclear division, negative regulation of cell cycle process, negative regulation of meiotic nuclear division, negative regulation of protein catabolic process, protein ubiquitination, regulation of meiotic nuclear division, regulation of mitotic nuclear division; MF: metal ion binding, protein binding, zinc ion binding; CC: female germ cell nucleus, nucleus
Pathways: Oocyte meiosis - Mus musculus (mouse)
UniProt: A0A2I3BQX6, G3X9B2
Entrez ID: 78803
|
Does Knockout of Milr1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Milr1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Milr1 (mast cell immunoglobulin like receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mast cell degranulation, negative regulation of mast cell activation; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: Q3TB92
Entrez ID: 380732
|
Does Knockout of Rbm7 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Rbm7
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rbm7 (RNA binding motif protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiotic cell cycle, regulation of alternative mRNA splicing, via spliceosome, snRNA catabolic process; MF: 14-3-3 protein binding, RNA binding, nucleic acid binding, pre-mRNA intronic binding, protein binding, single-stranded RNA binding, snRNA binding; CC: nucleoplasm, nucleus
Pathways: Metabolism of RNA, Nuclear RNA decay, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9CQT2
Entrez ID: 67010
|
Does Knockout of Vamp2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Vamp2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vamp2 (vesicle-associated membrane protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, SNARE complex assembly, calcium-ion regulated exocytosis, cellular response to insulin stimulus, eosinophil degranulation, establishment of localization in cell, exocytic insertion of neurotransmitter receptor to postsynaptic membrane, hormone secretion, long-term synaptic potentiation, membrane fusion, positive regulation of intracellular protein transport, protein transport, protein-containing complex assembly, regulated exocytosis, regulation of calcium ion-dependent exocytosis, regulation of delayed rectifier potassium channel activity, regulation of exocytosis, regulation of synaptic vesicle recycling, regulation of vesicle-mediated transport, response to cholesterol, response to glucose, synaptic vesicle docking, synaptic vesicle endocytosis, synaptic vesicle exocytosis, vesicle fusion, vesicle-mediated transport, vesicle-mediated transport in synapse; MF: SNAP receptor activity, SNARE binding, calcium-dependent protein binding, calmodulin binding, identical protein binding, lipid binding, molecular adaptor activity, myosin binding, phospholipid binding, protein binding, protein-containing complex binding, syntaxin binding, syntaxin-1 binding, transmembrane transporter binding; CC: SNARE complex, clathrin-coated vesicle, clathrin-sculpted glutamate transport vesicle membrane, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, glutamatergic synapse, membrane, neuron projection terminus, perinuclear region of cytoplasm, plasma membrane, postsynaptic cytosol, postsynaptic density, secretory granule, secretory granule membrane, storage vacuole, synapse, synaptic vesicle, synaptic vesicle membrane, synaptobrevin 2-SNAP-25-syntaxin-1a complex, synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex, synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex, trans-Golgi network, vesicle, voltage-gated potassium channel complex, zymogen granule membrane
Pathways: Acetylcholine Neurotransmitter Release Cycle, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Cytokine Signaling in Immune system, Dopamine Neurotransmitter Release Cycle, GABA synthesis, release, reuptake and degradation, Glutamate Neurotransmitter Release Cycle, Golgi Associated Vesicle Biogenesis, Immune System, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, Insulin secretion - Mus musculus (mouse), Lysosome Vesicle Biogenesis, Membrane Trafficking, Neuronal System, Neurotransmitter release cycle, Norepinephrine Neurotransmitter Release Cycle, Other interleukin signaling, Protein localization, SNARE interactions in vesicular transport - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Serotonin Neurotransmitter Release Cycle, Signaling by Interleukins, Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Vasopressin-regulated water reabsorption - Mus musculus (mouse), Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: P63044
Entrez ID: 22318
|
Does Knockout of Tmem115 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Tmem115
|
cell cycle progression
|
breast epithelium
|
Gene: Tmem115 (transmembrane protein 115)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; MF: identical protein binding; CC: Golgi apparatus, Golgi cisterna membrane, Golgi transport complex, membrane, nucleus
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9WUH1
Entrez ID: 56395
|
Does Knockout of Cblc in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Cblc
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cblc (Casitas B-lineage lymphoma c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, negative regulation of MAPK cascade, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of neuron apoptotic process, protein catabolic process, protein stabilization, protein ubiquitination, regulation of signaling, response to glial cell derived neurotrophic factor, signal transduction, ubiquitin-dependent protein catabolic process; MF: SH3 domain binding, calcium ion binding, epidermal growth factor receptor binding, metal ion binding, phosphotyrosine residue binding, protein binding, receptor tyrosine kinase binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: membrane raft, plasma membrane, ubiquitin ligase complex
Pathways: Endocytosis - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q80XL1
Entrez ID: 80794
|
Does Knockout of Npm1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Npm1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Npm1 (nucleophosmin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, cell volume homeostasis, cellular response to UV, cellular senescence, centrosome cycle, chromatin remodeling, cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), intracellular protein localization, macrophage differentiation, negative regulation of apoptotic process, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell population proliferation, negative regulation of centrosome duplication, negative regulation of epithelial cell proliferation, negative regulation of gene expression, negative regulation of mRNA splicing, via spliceosome, negative regulation of neuron apoptotic process, negative regulation of protein kinase activity by regulation of protein phosphorylation, nucleocytoplasmic transport, nucleosome assembly, positive regulation of DNA metabolic process, positive regulation of DNA replication, positive regulation of DNA-templated transcription, positive regulation of biosynthetic process, positive regulation of cell cycle G2/M phase transition, positive regulation of cell population proliferation, positive regulation of centrosome duplication, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein localization to nucleolus, positive regulation of protein ubiquitination, positive regulation of transcription by RNA polymerase II, positive regulation of translation, post-transcriptional regulation of gene expression, protein import into nucleus, protein stabilization, rRNA transcription, regulation of DNA damage response, signal transduction by p53 class mediator, regulation of cell cycle, regulation of cell growth, regulation of cell population proliferation, regulation of centriole replication, regulation of centrosome duplication, regulation of eIF2 alpha phosphorylation by dsRNA, regulation of mRNA stability involved in cellular response to UV, regulation of neuron apoptotic process, regulation of protein stability, ribosomal large subunit biogenesis, ribosomal large subunit export from nucleus, ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus; MF: ATP binding, DNA binding, DNA-binding transcription factor binding, NF-kappaB binding, RNA binding, Tat protein binding, chromatin binding, core promoter sequence-specific DNA binding, enzyme binding, histone binding, identical protein binding, molecular adaptor activity, nucleic acid binding, p53 binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding, protein homodimerization activity, protein kinase B binding, protein kinase binding, protein kinase inhibitor activity, rRNA binding, ribosomal large subunit binding, ribosomal small subunit binding, transcription coactivator activity, unfolded protein binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, granular component, large ribosomal subunit, nuclear matrix, nuclear speck, nucleolus, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, ribonucleoprotein complex, small ribosomal subunit, spindle pole centrosome
Pathways: Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Chromosome Maintenance, Cytokine Signaling in Immune system, Deposition of new CENPA-containing nucleosomes at the centromere, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Interferon Signaling, Metabolism of proteins, Nucleosome assembly, PKR-mediated signaling, Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation, TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
UniProt: Q61937
Entrez ID: 18148
|
Does Knockout of Mir7240 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Mir7240
|
cell cycle progression
|
breast epithelium
|
Gene: Mir7240 (microRNA 7240)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102466823
|
Does Knockout of Ermard in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Ermard
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ermard (ER membrane associated RNA degradation)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C9C8, E9Q048, A0A2I3BPX2, A0A2I3BQD2, A0A2I3BPT5, A0A2I3BQP4, A0A2I3BQS2, A0A2I3BQQ1
Entrez ID: 381062
|
Does Knockout of Kcna1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Kcna1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Kcna1 (potassium voltage-gated channel, shaker-related subfamily, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, brain development, cell communication by electrical coupling, cellular response to magnesium ion, detection of mechanical stimulus involved in sensory perception of pain, detection of mechanical stimulus involved in sensory perception of touch, hippocampus development, intracellular protein localization, magnesium ion homeostasis, membrane repolarization during action potential, monoatomic ion transmembrane transport, monoatomic ion transport, neuroblast proliferation, neuromuscular process, neuronal action potential, neuronal signal transduction, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of membrane potential, regulation of muscle contraction, startle response, transmembrane transport; MF: delayed rectifier potassium channel activity, disordered domain specific binding, monoatomic ion channel activity, potassium channel activity, protein binding, voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, voltage-gated potassium channel activity; CC: anchoring junction, apical plasma membrane, axon, axon initial segment, axon terminus, calyx of Held, cell junction, cell projection, cell surface, cytoplasmic vesicle, cytosol, dendrite, endoplasmic reticulum, glutamatergic synapse, juxtaparanode region of axon, membrane, monoatomic ion channel complex, neuronal cell body, paranode region of axon, perikaryon, plasma membrane, postsynaptic membrane, potassium channel complex, presynapse, presynaptic membrane, synapse, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: P16388
Entrez ID: 16485
|
Does Knockout of Gm13040 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Gm13040
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gm13040 (predicted gene 13040)
Type: protein-coding
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to several human genes including PRAMEF1 (PRAME family member 1); PRAMEF10 (PRAME family member 10); and PRAMEF11 (PRAME family member 11). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cellular_component, cytoplasm
Pathways:
UniProt: Q4FZF9
Entrez ID: 100040854
|
Does Knockout of Gm21927 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Gm21927
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Gm21927 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100417844
|
Does Knockout of Bag6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Bag6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Bag6 (BCL2-associated athanogene 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, NK T cell activation, antigen processing and presentation of peptide antigen via MHC class I, apoptotic process, brain development, cell differentiation, chromatin organization, endoplasmic reticulum stress-induced pre-emptive quality control, immune response-activating cell surface receptor signaling pathway, immune system process, internal peptidyl-lysine acetylation, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, kidney development, lung development, maintenance of unfolded protein, natural killer cell activation, negative regulation of apoptotic process, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of proteolysis, positive regulation of ERAD pathway, post-translational protein targeting to endoplasmic reticulum membrane, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization, regulation of apoptotic process, regulation of embryonic development, regulation of protein stability, spermatogenesis, synaptonemal complex assembly, tail-anchored membrane protein insertion into ER membrane, ubiquitin-dependent protein catabolic process; MF: Hsp70 protein binding, identical protein binding, misfolded protein binding, molecular adaptor activity, molecular function activator activity, polyubiquitin modification-dependent protein binding, proteasome binding, protein binding, protein carrier chaperone, receptor ligand activity, ribosome binding, signaling receptor binding, ubiquitin protein ligase binding, ubiquitin-specific protease binding; CC: BAT3 complex, cytoplasm, cytosol, extracellular exosome, extracellular region, membrane, nucleoplasm, nucleus
Pathways:
UniProt: Q9Z1R2
Entrez ID: 224727
|
Does Knockout of Mkrn2os in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Mkrn2os
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mkrn2os (makorin, ring finger protein 2, opposite strand)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D3YX48, D3Z393
Entrez ID: 70291
|
Does Knockout of Htr2b in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Htr2b
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Htr2b (5-hydroxytryptamine (serotonin) receptor 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERK1 and ERK2 cascade, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor signaling pathway, cGMP-mediated signaling, calcium-mediated signaling, cardiac muscle hypertrophy, cellular response to amine stimulus, cellular response to serotonin, chemical synaptic transmission, embryonic morphogenesis, heart development, heart morphogenesis, intestine smooth muscle contraction, intracellular calcium ion homeostasis, monoatomic ion transmembrane transport, negative regulation of apoptotic process, neural crest cell differentiation, neural crest cell migration, phospholipase C-activating serotonin receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell division, positive regulation of cell population proliferation, positive regulation of cytokine production, positive regulation of endothelial cell proliferation, positive regulation of phosphatidylinositol biosynthetic process, regulation of behavior, release of sequestered calcium ion into cytosol, response to xenobiotic stimulus, serotonin receptor signaling pathway, signal transduction, smooth muscle contraction, vasoconstriction; MF: G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, G-protein alpha-subunit binding, GTPase activator activity, Gq/11-coupled serotonin receptor activity, neurotransmitter receptor activity, serotonin binding, serotonin receptor activity; CC: G protein-coupled serotonin receptor complex, cytoplasm, dendrite, membrane, neuron projection, neuronal cell body, nucleoplasm, plasma membrane, synapse
Pathways: Amine ligand-binding receptors, Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Gap junction - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Serotonin receptors, Signal Transduction, Signaling by GPCR
UniProt: Q02152
Entrez ID: 15559
|
Does Knockout of Mex3c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Mex3c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mex3c (mex3 RNA binding family member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chondrocyte hypertrophy, energy homeostasis, regulation of fat cell differentiation; MF: RNA binding, metal ion binding, nucleic acid binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q05A36
Entrez ID: 240396
|
Does Knockout of Prelid2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Prelid2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Prelid2 (PRELI domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermembrane lipid transfer, phospholipid transport; CC: mitochondrial intermembrane space, mitochondrion
Pathways:
UniProt: Q0VBB0
Entrez ID: 77619
|
Does Knockout of Itln1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Itln1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Itln1 (intelectin 1 (galactofuranose binding))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of D-glucose import, positive regulation of protein phosphorylation, response to nematode; MF: calcium ion binding, carbohydrate binding, identical protein binding, metal ion binding, oligosaccharide binding; CC: brush border membrane, extracellular matrix, extracellular region, extracellular space, membrane, membrane raft, plasma membrane, receptor complex, side of membrane
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: O88310
Entrez ID: 16429
|
Does Knockout of Racgap1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Racgap1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Racgap1 (Rac GTPase-activating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, actomyosin contractile ring assembly, cell differentiation, cell division, erythrocyte differentiation, mitotic cytokinesis, mitotic spindle midzone assembly, monoatomic ion transport, neuroblast proliferation, positive regulation of cytokinesis, regulation of attachment of spindle microtubules to kinetochore, regulation of embryonic development, signal transduction, spermatogenesis, sulfate transmembrane transport; MF: GTPase activator activity, alpha-tubulin binding, beta-tubulin binding, gamma-tubulin binding, lipid binding, metal ion binding, microtubule binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein kinase binding, protein-macromolecule adaptor activity, zinc ion binding; CC: Flemming body, acrosomal vesicle, centralspindlin complex, cleavage furrow, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, membrane, midbody, mitotic spindle, nucleoplasm, nucleus, plasma membrane, spindle, spindle midzone
Pathways: Adaptive Immune System, CDC42 GTPase cycle, COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q9WVM1
Entrez ID: 26934
|
Does Knockout of Med1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Med1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Med1 (mediator complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, androgen biosynthetic process, angiogenesis, animal organ morphogenesis, animal organ regeneration, brain development, camera-type eye development, cell morphogenesis, cellular response to epidermal growth factor stimulus, cellular response to hepatocyte growth factor stimulus, cellular response to steroid hormone stimulus, cellular response to thyroid hormone stimulus, embryonic heart tube development, embryonic hemopoiesis, embryonic hindlimb morphogenesis, embryonic placenta development, enucleate erythrocyte development, epithelial cell proliferation involved in mammary gland duct elongation, erythrocyte development, fat cell differentiation, heart development, hematopoietic stem cell differentiation, in utero embryonic development, keratinocyte differentiation, lactation, lens development in camera-type eye, liver development, mRNA transcription by RNA polymerase II, mammary gland branching involved in pregnancy, mammary gland branching involved in thelarche, mammary gland epithelial cell proliferation, megakaryocyte development, monocyte differentiation, negative regulation of apoptotic process, negative regulation of keratinocyte proliferation, negative regulation of neuron differentiation, negative regulation of transcription by RNA polymerase II, nuclear receptor-mediated steroid hormone signaling pathway, peroxisome proliferator activated receptor signaling pathway, positive regulation of DNA-templated transcription, positive regulation of G0 to G1 transition, positive regulation of cell population proliferation, positive regulation of erythrocyte differentiation, positive regulation of gene expression, positive regulation of hepatocyte proliferation, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of keratinocyte differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, positive regulation of type II interferon-mediated signaling pathway, protein import into nucleus, protein ubiquitination, regulation of DNA-templated transcription, regulation of RNA biosynthetic process, regulation of transcription by RNA polymerase II, regulation of vitamin D receptor signaling pathway, retinal pigment epithelium development, thyroid hormone generation, thyroid hormone receptor signaling pathway, transcription by RNA polymerase II, ventricular trabecula myocardium morphogenesis; MF: DNA binding, DNA-binding transcription factor binding, LBD domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, general transcription initiation factor binding, histone acetyltransferase binding, nuclear estrogen receptor binding, nuclear receptor binding, nuclear retinoic acid receptor binding, nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, peroxisome proliferator activated receptor binding, promoter-specific chromatin binding, protein binding, protein-containing complex binding, transcription coactivator activity, transcription coactivator binding, transcription coregulator activity, transcription corepressor activity, ubiquitin protein ligase activity; CC: chromatin, core mediator complex, mediator complex, nucleolus, nucleoplasm, nucleus, protein-DNA complex, ubiquitin ligase complex
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, ESR-mediated signaling, Estrogen-dependent gene expression, Gene expression (Transcription), Generic Transcription Pathway, Metabolism, Metabolism of lipids, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription, Regulation of lipid metabolism by PPARalpha, Signal Transduction, Signaling by Nuclear Receptors, Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: Q925J9
Entrez ID: 19014
|
Does Knockout of Cda in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Cda
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cda (cytidine deaminase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP catabolic process, UMP salvage, carbohydrate derivative metabolic process, cellular response to external biotic stimulus, dCMP catabolic process, nucleobase-containing small molecule metabolic process, pyrimidine-containing compound metabolic process; MF: catalytic activity, cytidine deaminase activity, deaminase activity, hydrolase activity, identical protein binding, metal ion binding, nucleoside binding, protein homodimerization activity, zinc ion binding; CC: cytoplasm, cytosol
Pathways: (deoxy)ribose phosphate degradation, Drug metabolism - other enzymes - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of nucleotides, Neutrophil degranulation, Nucleotide salvage, Pyrimidine metabolism - Mus musculus (mouse), Pyrimidine salvage, purine and pyrimidine metabolism, pyrimidine deoxyribonucleosides degradation, pyrimidine ribonucleosides degradation II, salvage pathways of pyrimidine deoxyribonucleotides, salvage pathways of pyrimidine ribonucleotides
UniProt: P56389
Entrez ID: 72269
|
Does Knockout of Cenpu in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Cenpu
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cenpu (centromere protein U)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chordate embryonic development, chromosome segregation; CC: centriolar satellite, chromosome, chromosome, centromeric region, cytoplasm, inner kinetochore, kinetochore, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8C4M7
Entrez ID: 71876
|
Does Knockout of Fam110c in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Fam110c
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Fam110c (family with sequence similarity 110, member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of cell projection assembly; MF: alpha-tubulin binding; CC: cell cortex, centrosome, cytoplasm, cytoskeleton, microtubule, nucleus, spindle pole
Pathways:
UniProt: Q8VE94
Entrez ID: 104943
|
Does Knockout of Sv2b in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Sv2b
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Sv2b (synaptic vesicle glycoprotein 2b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chemical synaptic transmission, neurotransmitter transport, regulation of presynaptic cytosolic calcium ion concentration, regulation of synaptic vesicle exocytosis, transmembrane transport; CC: acrosomal vesicle, cytoplasmic vesicle, glutamatergic synapse, membrane, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways: ECM-receptor interaction - Mus musculus (mouse)
UniProt: Q8BG39
Entrez ID: 64176
|
Does Knockout of Irx6 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Irx6
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Irx6 (Iroquois homeobox 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, cell development, detection of visible light, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, retina layer formation, retinal bipolar neuron differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q9ER75
Entrez ID: 64379
|
Does Knockout of Lsm1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Lsm1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lsm1 (LSM1 homolog, mRNA degradation associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, deadenylation-dependent decapping of nuclear-transcribed mRNA, histone mRNA catabolic process, mRNA processing, negative regulation of neuron differentiation, nuclear-transcribed mRNA catabolic process, stem cell population maintenance; MF: RNA binding, mRNA binding, pre-mRNA binding, protein binding; CC: Lsm1-7-Pat1 complex, P-body, axon, cytoplasm, dendrite, neuronal cell body, nucleus, ribonucleoprotein complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Mus musculus (mouse), mRNA decay by 5' to 3' exoribonuclease
UniProt: Q8VC85
Entrez ID: 67207
|
Does Knockout of Scube1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Scube1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Scube1 (signal peptide, CUB domain, EGF-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of smoothened signaling pathway, signal transduction; MF: calcium ion binding, identical protein binding, protein binding; CC: cell surface, external side of plasma membrane, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Degradation of the extracellular matrix, Extracellular matrix organization
UniProt: Q6NZL8
Entrez ID: 64706
|
Does Knockout of Rplp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Rplp1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rplp1 (ribosomal protein lateral stalk subunit P1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, regulation of translation, translational elongation; MF: protein kinase activator activity, ribonucleoprotein complex binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, postsynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P47955
Entrez ID: 56040
|
Does Knockout of Opa1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Opa1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Opa1 (OPA1, mitochondrial dynamin like GTPase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GTP metabolic process, apoptotic process, calcium import into the mitochondrion, cellular senescence, cristae formation, inner mitochondrial membrane organization, intracellular distribution of mitochondria, membrane fusion, membrane tubulation, mitochondrial fusion, mitochondrial inner membrane fusion, mitochondrion organization, negative regulation of apoptotic process, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of release of cytochrome c from mitochondria, neural tube closure, peroxisome fission, positive regulation of T-helper 17 cell lineage commitment, positive regulation of cellular response to insulin stimulus, positive regulation of dendrite development, positive regulation of dendritic spine morphogenesis, positive regulation of insulin receptor signaling pathway, positive regulation of interleukin-17 production, positive regulation of mitochondrial fusion, positive regulation of neuron maturation, protein complex oligomerization, regulation of mitochondrion organization, visual perception; MF: GTP binding, GTPase activity, GTPase-dependent fusogenic activity, cardiolipin binding, hydrolase activity, kinase binding, lipid binding, membrane bending activity, metal ion binding, microtubule binding, nucleotide binding, phosphatidic acid binding, protein binding, protein-containing complex binding; CC: cytoplasm, cytosol, dendrite, membrane, microtubule, mitochondrial crista, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, nucleoplasm
Pathways: Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: P58281
Entrez ID: 74143
|
Does Knockout of Lsm6 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Lsm6
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Lsm6 (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA catabolic process, mRNA processing, mRNA splicing, via spliceosome, maturation of SSU-rRNA, rRNA processing, tRNA processing; MF: RNA binding, protein heterodimerization activity; CC: Lsm2-8 complex, P-body, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, nucleolus, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex, spliceosomal complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: P62313
Entrez ID: 78651
|
Does Knockout of Trim62 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Trim62
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Trim62 (tripartite motif-containing 62)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, innate immune response, negative regulation of epithelial to mesenchymal transition, negative regulation of viral transcription, positive regulation of DNA-templated transcription, positive regulation of antifungal innate immune response, positive regulation of canonical NF-kappaB signal transduction, protein K27-linked ubiquitination, protein ubiquitination, regulation of viral entry into host cell, viral release from host cell; MF: identical protein binding, metal ion binding, transcription coactivator activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm
Pathways:
UniProt: Q80V85
Entrez ID: 67525
|
Does Knockout of Fnbp4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Fnbp4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Fnbp4 (formin binding protein 4)
Type: protein-coding
Summary: Predicted to be located in nucleoplasm. Is expressed in endolymphatic appendage and otocyst. Orthologous to human FNBP4 (formin binding protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q6ZQ03
Entrez ID: 55935
|
Does Knockout of Sfr1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,558
|
Knockout
|
Sfr1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Sfr1 (SWI5 dependent recombination repair 1)
Type: protein-coding
Summary: Predicted to enable transcription coactivator activity. Involved in double-strand break repair via homologous recombination. Located in nucleus. Part of Swi5-Sfr1 complex. Is expressed in olfactory cortex ventricular layer; pancreas epithelium; and telencephalon ventricular layer. Orthologous to human SFR1 (SWI5 dependent homologous recombination repair protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to estrogen stimulus, double-strand break repair via homologous recombination, positive regulation of DNA-templated transcription; MF: transcription coactivator activity; CC: Swi5-Sfr1 complex, centrosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8BP27
Entrez ID: 67788
|
Does Knockout of Gdf5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Gdf5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gdf5 (growth differentiation factor 5)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mice with a mutation in this gene exhibit enhanced tooth enamel formation. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: BMP signaling pathway, cartilage development, cell differentiation, cell surface receptor protein serine/threonine kinase signaling pathway, chondroblast differentiation, embryonic limb morphogenesis, forelimb morphogenesis, hindlimb morphogenesis, negative regulation of chondrocyte differentiation, negative regulation of epithelial cell proliferation, negative regulation of mesenchymal cell apoptotic process, negative regulation of neuron apoptotic process, ossification involved in bone remodeling, positive regulation of BMP signaling pathway, positive regulation of SMAD protein signal transduction, positive regulation of chondrocyte differentiation, positive regulation of neuron differentiation, regulation of multicellular organism growth, response to mechanical stimulus; MF: BMP binding, cytokine activity, growth factor activity, identical protein binding, protein binding, signaling receptor binding; CC: extracellular region, extracellular space, membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), Elastic fibre formation, Extracellular matrix organization, Hippo signaling pathway - Mus musculus (mouse), Molecules associated with elastic fibres, TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: P43027
Entrez ID: 14563
|
Does Knockout of Abca6 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Abca6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Abca6 (ATP-binding cassette, sub-family A member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid transport, transmembrane transport; MF: ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, lipid transporter activity, nucleotide binding; CC: Golgi apparatus, Golgi membrane, intracellular membrane-bounded organelle, membrane, nucleoplasm, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse), ABC transporters in lipid homeostasis, ABC-family proteins mediated transport, Transport of small molecules
UniProt: Q8K441
Entrez ID: 76184
|
Does Knockout of Pik3ca in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Pik3ca
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC2 signaling, actin cytoskeleton organization, adipose tissue development, angiogenesis, autosome genomic imprinting, cardiac muscle cell contraction, cell migration, cellular response to glucose stimulus, cellular response to hydrostatic pressure, cellular response to insulin stimulus, energy homeostasis, glucose metabolic process, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, liver development, negative regulation of actin filament depolymerization, negative regulation of anoikis, negative regulation of fibroblast apoptotic process, negative regulation of gene expression, negative regulation of neuron apoptotic process, phagocytosis, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to membrane, positive regulation of smooth muscle cell proliferation, regulation of actin filament organization, regulation of cellular respiration, regulation of gene expression, regulation of multicellular organism growth, relaxation of cardiac muscle, response to L-leucine, response to activity, response to butyrate, response to dexamethasone, response to hormone, response to muscle inactivity, response to muscle stretch, vascular endothelial growth factor signaling pathway; MF: 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, insulin receptor substrate binding, kinase activity, nucleotide binding, protein binding, protein kinase activator activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, intercalated disc, lamellipodium, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex, class IB, plasma membrane
Pathways: 3-phosphoinositide biosynthesis, AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), CD28 dependent PI3K/Akt signaling, Carbohydrate digestion and absorption - Mus musculus (mouse), Cell surface interactions at the vascular wall, Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Co-stimulation by CD28, Co-stimulation by ICOS, Colorectal cancer - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), Downstream TCR signaling, Downstream signal transduction, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, ESR-mediated signaling, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Estrogen signaling pathway - Mus musculus (mouse), Extra-nuclear estrogen signaling, FLT3 Signaling, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G alpha (q) signalling events, GAB1 signalosome, GPCR downstream signalling, GPVI-mediated activation cascade, Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Innate Immune System, Inositol phosphate metabolism - Mus musculus (mouse), Insulin receptor signalling cascade, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, MET activates PI3K/AKT signaling, Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Metabolism, Metabolism of lipids, MicroRNAs in cancer - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI Metabolism, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K events in ERBB2 signaling, PI3K events in ERBB4 signaling, PI3K-Akt signaling pathway - Mus musculus (mouse), PI3K/AKT activation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP metabolism, PIP3 activates AKT signaling, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Prion disease - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAF/MAP kinase cascade, RET signaling, RHO GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Regulation of signaling by CBL, Relaxin signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Role of LAT2/NTAL/LAB on calcium mobilization, Role of phospholipids in phagocytosis, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by ALK, Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by Erythropoietin, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by LTK, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Nuclear Receptors, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by VEGF, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Synthesis of PIPs at the plasma membrane, T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling, TNF signaling pathway - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Tie2 Signaling, Toll-like receptor signaling pathway - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P42337
Entrez ID: 18706
|
Does Knockout of Mkrn2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,286
|
Knockout
|
Mkrn2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mkrn2 (makorin, ring finger protein, 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, cell differentiation, negative regulation of inflammatory response to antigenic stimulus, negative regulation of non-canonical NF-kappaB signal transduction, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of transcription by RNA polymerase II, protein polyubiquitination, protein ubiquitination, spermatogenesis, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9ERV1
Entrez ID: 67027
|
Does Knockout of Ptbp1 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Ptbp1
|
response to virus
|
Microglial Cell Line
|
Gene: Ptbp1 (polypyrimidine tract binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRES-dependent viral translational initiation, RNA splicing, gene expression, mRNA processing, negative regulation of RNA splicing, negative regulation of gene expression, negative regulation of mRNA metabolic process, negative regulation of mRNA splicing, via spliceosome, negative regulation of muscle cell differentiation, negative regulation of neuron differentiation, neurogenesis, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of transcription by RNA polymerase II, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome, regulation of cell differentiation; MF: RNA binding, mRNA binding, nucleic acid binding, pre-mRNA binding, protein binding, regulatory region RNA binding, sequence-specific DNA binding, single-stranded DNA binding, single-stranded DNA endodeoxyribonuclease activity; CC: neuron projection terminus, nucleus
Pathways: FGFR2 alternative splicing, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Receptor Tyrosine Kinases, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P17225
Entrez ID: 19205
|
Does Knockout of Tceanc2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Tceanc2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Tceanc2 (transcription elongation factor A (SII) N-terminal and central domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, regulation of transcription by RNA polymerase II; CC: nucleus
Pathways:
UniProt: Q8R2M0
Entrez ID: 66526
|
Does Knockout of Pcdhga6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Pcdhga6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcdhga6 (protocadherin gamma subfamily A, 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: Q91XY2
Entrez ID: 93714
|
Does Knockout of Tinf2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Tinf2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tinf2 (Terf1 (TRF1)-interacting nuclear factor 2)
Type: protein-coding
Summary: Enables telomeric DNA binding activity. Acts upstream of or within negative regulation of telomere maintenance. Located in chromosome, telomeric region. Is expressed in several structures, including genitourinary system; midbrain ventricular layer; olfactory epithelium; telencephalon; and thymus primordium. Used to study dyskeratosis congenita. Human ortholog(s) of this gene implicated in Revesz syndrome and autosomal dominant dyskeratosis congenita 3. Orthologous to human TINF2 (TERF1 interacting nuclear factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of epithelial cell proliferation, negative regulation of telomere maintenance, negative regulation of telomere maintenance via telomerase, positive regulation of telomere maintenance, protein localization to chromosome, telomeric region, regulation of telomere maintenance via telomere lengthening, telomere assembly, telomere capping; MF: protein binding, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, nuclear body, nuclear telomere cap complex, nucleoplasm, nucleus, perinucleolar chromocenter, shelterin complex
Pathways:
UniProt: A0A2I3BRL3, Q8K1K3, A0A2I3BRI7, A0A2I3BRW2, A0A2I3BPS4
Entrez ID: 28113
|
Does Knockout of Plp2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Plp2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Plp2 (proteolipid protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: chemokine binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9R1Q7
Entrez ID: 18824
|
Does Knockout of Cdkn2aipnl in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Cdkn2aipnl
|
cell cycle progression
|
breast epithelium
|
Gene: Cdkn2aipnl (CDKN2A interacting protein N-terminal like)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D211
Entrez ID: 52626
|
Does Knockout of Car2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Car2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Car2 (carbonic anhydrase 2)
Type: protein-coding
Summary: Enables carbonate dehydratase activity. Involved in positive regulation of dipeptide transmembrane transport and regulation of intracellular pH. Acts upstream of or within several processes, including positive regulation of GABAergic synaptic transmission; positive regulation of cellular pH reduction; and regulation of chloride transport. Located in cytosol and myelin sheath. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Used to study autosomal recessive osteopetrosis 3. Human ortholog(s) of this gene implicated in alcoholic pancreatitis; autoimmune disease (multiple); osteopetrosis (multiple); and viral hepatitis. Orthologous to human CA2 (carbonic anhydrase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: angiotensin-activated signaling pathway, carbon dioxide transport, cellular response to fluid shear stress, estrous cycle, kidney development, morphogenesis of an epithelium, neuron cellular homeostasis, odontogenesis of dentin-containing tooth, positive regulation of bone resorption, positive regulation of cellular pH reduction, positive regulation of dipeptide transmembrane transport, positive regulation of osteoclast differentiation, positive regulation of synaptic transmission, GABAergic, regulation of chloride transport, regulation of intracellular pH, regulation of monoatomic anion transport, regulation of pH, response to estrogen, response to formaldehyde, response to pH, response to steroid hormone, response to zinc ion, secretion; MF: arylesterase activity, carbonate dehydratase activity, cyanamide hydratase activity, lyase activity, metal ion binding, protein binding, zinc ion binding; CC: apical part of cell, axon, basolateral plasma membrane, cytoplasm, cytosol, extracellular space, membrane, microvillus, myelin sheath, plasma membrane
Pathways: Bile secretion - Mus musculus (mouse), Collecting duct acid secretion - Mus musculus (mouse), Erythrocytes take up carbon dioxide and release oxygen, Erythrocytes take up oxygen and release carbon dioxide, Gastric acid secretion - Mus musculus (mouse), Metabolism, Nitrogen metabolism - Mus musculus (mouse), O2/CO2 exchange in erythrocytes, Pancreatic secretion - Mus musculus (mouse), Proximal tubule bicarbonate reclamation - Mus musculus (mouse), Reversible hydration of carbon dioxide, Transport of small molecules
UniProt: P00920
Entrez ID: 12349
|
Does Knockout of Arx in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Arx
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Arx (aristaless related homeobox)
Type: protein-coding
Summary: This gene encodes a transcription factor that plays an important role in the development of forebrain. Male mice lacking this gene have smaller brains, olfactory bulbs and testes, and die within half a day after birth. Mice lacking this gene specifically in ganglionic eminence-derived neurons, including cortical interneurons, develop seizures. Mutations in this gene have been demonstrated to cause mouse phenotypes resembling human X-linked lissencephaly and cognitive disability with epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: axon guidance, cell differentiation, cell proliferation in forebrain, cerebral cortex GABAergic interneuron migration, cerebral cortex tangential migration, embryonic olfactory bulb interneuron precursor migration, epithelial cell fate commitment, forebrain development, globus pallidus development, interneuron migration, lipid digestion, negative regulation of transcription by RNA polymerase II, nervous system development, neuron development, neuron fate commitment, neuron migration, olfactory bulb development, positive regulation of gene expression, positive regulation of organ growth, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of epithelial cell proliferation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: O35085
Entrez ID: 11878
|
Does Knockout of Cass4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Cass4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cass4 (Cas scaffolding protein family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell migration, cell surface receptor protein tyrosine kinase signaling pathway, positive regulation of cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein tyrosine kinase activity, positive regulation of substrate adhesion-dependent cell spreading; MF: protein tyrosine kinase binding; CC: anchoring junction, cytoplasm, cytoskeleton, focal adhesion, plasma membrane
Pathways:
UniProt: Q08EC4
Entrez ID: 320664
|
Does Knockout of Ppp1r12b in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Ppp1r12b
|
cell proliferation
|
Regulatory T cell
|
Gene: Ppp1r12b (protein phosphatase 1, regulatory subunit 12B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuron projection morphogenesis, signal transduction; MF: enzyme inhibitor activity, myosin phosphatase regulator activity, phosphatase regulator activity, protein kinase binding; CC: A band, Z disc, cytoplasm, cytoskeleton, stress fiber
Pathways: Cell Cycle, Cell Cycle, Mitotic, Focal adhesion - Mus musculus (mouse), G2/M Transition, Mitotic G2-G2/M phases, Oxytocin signaling pathway - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases activate PAKs, RHO GTPases activate PKNs, Regulation of PLK1 Activity at G2/M Transition, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vascular smooth muscle contraction - Mus musculus (mouse)
UniProt: Q8BG95
Entrez ID: 329251
|
Does Knockout of Prkab1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Prkab1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Prkab1 (protein kinase, AMP-activated, beta 1 non-catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to nutrient levels, fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, nail development, positive regulation of cold-induced thermogenesis, signal transduction; MF: AMP-activated protein kinase activity, protein binding, protein kinase binding; CC: cytoplasm, cytosol, nucleotide-activated protein kinase complex, nucleus, protein-containing complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Autophagy, Circadian rhythm - Mus musculus (mouse), Co-inhibition by PD-1, Energy dependent regulation of mTOR by LKB1-AMPK, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling pathway - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Immune System, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MTOR signalling, Macroautophagy, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Transcriptional Regulation by TP53
UniProt: Q9R078
Entrez ID: 19079
|
Does Knockout of Stk11 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Stk11
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Stk11 (serine/threonine kinase 11)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: DNA damage response, G1 to G0 transition, Golgi localization, T cell receptor signaling pathway, anoikis, apoptotic process, autophagy, axonogenesis, cell differentiation, cellular response to UV-B, dendrite extension, establishment of cell polarity, glucose homeostasis, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of TORC1 signaling, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of cold-induced thermogenesis, negative regulation of epithelial cell proliferation involved in prostate gland development, positive regulation of autophagy, positive regulation of axonogenesis, positive regulation of gluconeogenesis, positive regulation of protein localization to nucleus, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of vesicle transport along microtubule, positive thymic T cell selection, protein autophosphorylation, protein dephosphorylation, protein phosphorylation, regulation of Wnt signaling pathway, regulation of cell growth, regulation of dendrite morphogenesis, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, response to ionizing radiation, response to lipid, signal transduction, spermatid development, spermatogenesis, tissue homeostasis, vasculature development; MF: ATP binding, LRR domain binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, p53 binding, protein binding, protein kinase activator activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: Z disc, centrosome, cilium, cytoplasm, cytosol, intracellular protein-containing complex, membrane, mitochondrion, nucleoplasm, nucleus, protein-containing complex, serine/threonine protein kinase complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Energy dependent regulation of mTOR by LKB1-AMPK, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Longevity regulating pathway - Mus musculus (mouse), MTOR signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, Tight junction - Mus musculus (mouse), Transcriptional Regulation by TP53, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9WTK7
Entrez ID: 20869
|
Does Knockout of Med17 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Med17
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Med17 (mediator complex subunit 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance; MF: nuclear thyroid hormone receptor binding, protein binding, transcription coactivator activity, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, transcription regulator complex, ubiquitin ligase complex
Pathways: Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: Q8VCD5
Entrez ID: 234959
|
Does Knockout of Supt4a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Supt4a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Supt4a (SPT4A, DSIF elongation factor subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, elongation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription elongation by RNA polymerase II, transcription elongation by RNA polymerase II, transcription elongation-coupled chromatin remodeling; MF: RNA polymerase II complex binding, metal ion binding, protein heterodimerization activity, zinc ion binding; CC: DSIF complex, nucleoplasm, nucleus
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA polymerase II transcribes snRNA genes, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: P63271
Entrez ID: 20922
|
Does Knockout of Lonp1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Lonp1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lonp1 (lon peptidase 1, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress, chaperone-mediated protein complex assembly, mitochondrial protein catabolic process, mitochondrion organization, negative regulation of insulin receptor signaling pathway, oxidation-dependent protein catabolic process, protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins, protein-containing complex assembly, proteolysis, proteolysis involved in protein catabolic process, response to aluminum ion, response to hormone, response to hypoxia; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, DNA binding, DNA polymerase binding, G-quadruplex DNA binding, PH domain binding, hydrolase activity, identical protein binding, insulin receptor substrate binding, mitochondrial promoter sequence-specific DNA binding, nucleotide binding, peptidase activity, sequence-specific DNA binding, serine-type endopeptidase activity, serine-type peptidase activity, single-stranded DNA binding, single-stranded RNA binding; CC: cytosol, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleoplasm
Pathways: Metabolism of proteins, Mitochondrial protein degradation
UniProt: Q8CGK3
Entrez ID: 74142
|
Does Knockout of Dmkn in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Dmkn
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dmkn (dermokine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cornified envelope assembly; CC: extracellular region, extracellular space
Pathways:
UniProt: Q6P253
Entrez ID: 73712
|
Does Knockout of Ranbp2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Ranbp2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ranbp2 (RAN binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, centrosome localization, cytoplasmic pattern recognition receptor signaling pathway, intracellular glucose homeostasis, mRNA transport, negative regulation of RNA export from nucleus, negative regulation of innate immune response, nuclear export, nucleocytoplasmic transport, protein folding, protein sumoylation, protein transport, regulation of gluconeogenesis, response to amphetamine, toll-like receptor signaling pathway; MF: GTPase activator activity, RNA binding, SUMO ligase activity, SUMO transferase activity, kinase activator activity, metal ion binding, peptidyl-prolyl cis-trans isomerase activity, protein binding, protein-containing complex binding, small GTPase binding, transferase activity, zinc ion binding; CC: SUMO ligase complex, annulate lamellae, cytoplasm, cytoplasmic periphery of the nuclear pore complex, cytosol, membrane, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear pore, nuclear pore cytoplasmic filaments, nuclear pore nuclear basket, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q9ERU9
Entrez ID: 19386
|
Does Knockout of Mtdh in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Mtdh
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mtdh (metadherin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipopolysaccharide-mediated signaling pathway, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of NF-kappaB transcription factor activity, positive regulation of angiogenesis, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of transcription by RNA polymerase II; MF: NF-kappaB binding, RNA polymerase II-specific DNA-binding transcription factor binding, double-stranded RNA binding, protein binding, transcription coactivator activity, transcription coregulator activity; CC: anchoring junction, apical plasma membrane, bicellular tight junction, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, fibrillar center, intercellular canaliculus, membrane, nuclear body, nuclear membrane, nucleolus, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q80WJ7
Entrez ID: 67154
|
Does Knockout of Stac3 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Stac3
|
phagocytosis
|
macrophage
|
Gene: Stac3 (SH3 and cysteine rich domain 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuromuscular synaptic transmission, positive regulation of protein localization to plasma membrane, positive regulation of voltage-gated calcium channel activity, skeletal muscle contraction, skeletal muscle fiber development; MF: identical protein binding, metal ion binding, zinc ion binding; CC: T-tubule, cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane, nucleoplasm, plasma membrane, sarcolemma, synapse, voltage-gated calcium channel complex
Pathways:
UniProt: Q8BZ71
Entrez ID: 237611
|
Does Knockout of Rdh5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Rdh5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rdh5 (retinol dehydrogenase 5)
Type: protein-coding
Summary: Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in retinoid metabolic process. Located in endoplasmic reticulum lumen. Is expressed in several structures, including aorta-gonad-mesonephros; central nervous system; embryo ectoderm; eye; and gut. Human ortholog(s) of this gene implicated in fundus albipunctatus and night blindness. Orthologous to human RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: lipid metabolic process, retinoid metabolic process, retinol metabolic process, steroid metabolic process, visual perception; MF: 11-cis-retinol dehydrogenase (NAD+) activity, all-trans-retinol dehydrogenase (NAD+) activity, androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, oxidoreductase activity, protein homodimerization activity; CC: cell body, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, The canonical retinoid cycle in rods (twilight vision), Visual phototransduction
UniProt: O55240
Entrez ID: 19682
|
Does Knockout of Senp6 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Senp6
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Senp6 (SUMO/sentrin specific peptidase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein desumoylation, protein modification by small protein removal, protein sumoylation, proteolysis, regulation of kinetochore assembly, regulation of spindle assembly; MF: SUMO-specific endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, postsynaptic cytosol, presynaptic cytosol
Pathways:
UniProt: Q6P7W0
Entrez ID: 215351
|
Does Knockout of Mtor in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Mtor
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mtor (mechanistic target of rapamycin kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' pyrimidine nucleobase biosynthetic process, DNA damage response, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, T-helper 1 cell lineage commitment, TOR signaling, TORC1 signaling, TORC2 signaling, antibacterial innate immune response, autophagosome assembly, behavioral response to pain, cardiac cell development, cardiac muscle cell development, cardiac muscle contraction, cardiac muscle tissue development, cell projection organization, cellular response to L-leucine, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to hypoxia, cellular response to insulin stimulus, cellular response to leucine starvation, cellular response to methionine, cellular response to nutrient, cellular response to nutrient levels, cellular response to osmotic stress, cellular response to starvation, cytoplasmic translation, cytoskeleton organization, energy reserve metabolic process, germ cell development, heart morphogenesis, heart valve morphogenesis, inflammatory response, insulin receptor signaling pathway, long-term memory, lysosome organization, mRNA stabilization, maternal process involved in female pregnancy, multicellular organism growth, negative regulation of TORC1 signaling, negative regulation of TORC2 signaling, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of calcineurin-NFAT signaling cascade, negative regulation of cell size, negative regulation of cholangiocyte apoptotic process, negative regulation of innate immune response, negative regulation of insulin receptor signaling pathway, negative regulation of iodide transmembrane transport, negative regulation of lysosome organization, negative regulation of macroautophagy, negative regulation of muscle atrophy, negative regulation of protein localization to nucleus, negative regulation of protein ubiquitination, negative regulation of translational initiation, negative regulation of ubiquitin-dependent protein catabolic process, neuronal action potential, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process, positive regulation of TORC1 signaling, positive regulation of actin filament polymerization, positive regulation of autophagy, positive regulation of biosynthetic process, positive regulation of cell growth, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of cell population proliferation, positive regulation of cell projection organization, positive regulation of cellular senescence, positive regulation of cholangiocyte proliferation, positive regulation of dendritic spine development, positive regulation of eating behavior, positive regulation of endothelial cell proliferation, positive regulation of epithelial cell apoptotic process, positive regulation of epithelial to mesenchymal transition, positive regulation of glial cell proliferation, positive regulation of glycolytic process, positive regulation of granulosa cell proliferation, positive regulation of keratinocyte migration, positive regulation of lamellipodium assembly, positive regulation of lipid biosynthetic process, positive regulation of myotube differentiation, positive regulation of neurogenesis, positive regulation of neuron apoptotic process, positive regulation of neuron maturation, positive regulation of neuron projection development, positive regulation of nitric oxide biosynthetic process, positive regulation of oligodendrocyte differentiation, positive regulation of pentose-phosphate shunt, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of ruffle assembly, positive regulation of skeletal muscle hypertrophy, positive regulation of smooth muscle cell proliferation, positive regulation of stress fiber assembly, positive regulation of striated muscle cell differentiation, positive regulation of transcription by RNA polymerase III, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, positive regulation of translation, positive regulation of translational initiation, positive regulation of ubiquitin-dependent protein catabolic process, positive regulation of wound healing, spreading of epidermal cells, post-embryonic development, protein destabilization, regulation of actin cytoskeleton organization, regulation of autophagosome assembly, regulation of autophagy, regulation of behavior, regulation of brown fat cell differentiation, regulation of carbohydrate metabolic process, regulation of carbohydrate utilization, regulation of cell growth, regulation of cell size, regulation of circadian rhythm, regulation of fatty acid beta-oxidation, regulation of glycogen biosynthetic process, regulation of lipid metabolic process, regulation of locomotor rhythm, regulation of lysosome organization, regulation of membrane permeability, regulation of myelination, regulation of osteoclast differentiation, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of plasma membrane bounded cell projection organization, regulation of response to food, regulation of translation at synapse, modulating synaptic transmission, regulation of translational initiation, response to amino acid, response to cocaine, response to heat, response to insulin, response to nutrient levels, response to virus, social behavior, spinal cord development, ubiquitin-dependent protein catabolic process, visual learning, voluntary musculoskeletal movement; MF: ATP binding, RNA polymerase III type 1 promoter sequence-specific DNA binding, RNA polymerase III type 2 promoter sequence-specific DNA binding, RNA polymerase III type 3 promoter sequence-specific DNA binding, TFIIIC-class transcription factor complex binding, identical protein binding, inositol hexakisphosphate binding, kinase activity, metal ion binding, nucleotide binding, phosphoprotein binding, protein binding, protein domain specific binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, protein-containing complex binding, ribosome binding, transferase activity, transmembrane transporter binding; CC: Golgi apparatus, Golgi membrane, PML body, TORC1 complex, TORC2 complex, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, glutamatergic synapse, lysosomal membrane, lysosome, membrane, mitochondrial outer membrane, mitochondrion, neuronal cell body, nuclear envelope, nucleus, phagocytic vesicle, plasma membrane, postsynaptic cytosol, protein-containing complex, serine/threonine protein kinase complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amino acids regulate mTORC1, Amyotrophic lateral sclerosis - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), CD28 dependent PI3K/Akt signaling, Cellular response to heat stress, Cellular response to starvation, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Co-stimulation by CD28, Colorectal cancer - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Energy dependent regulation of mTOR by LKB1-AMPK, ErbB signaling pathway - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glioma - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), HSF1-dependent transactivation, Hepatocellular carcinoma - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Immune System, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MTOR signalling, Macroautophagy, MicroRNAs in cancer - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PIP3 activates AKT signaling, PTEN Regulation, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Response of endothelial cells to shear stress, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Spinocerebellar ataxia - Mus musculus (mouse), TP53 Regulates Metabolic Genes, Th17 cell differentiation - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional Regulation by TP53, Type II diabetes mellitus - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q9JLN9
Entrez ID: 56717
|
Does Knockout of Tardbp in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Tardbp
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tardbp (TAR DNA binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, 3'-UTR-mediated mRNA stabilization, RNA splicing, amyloid fibril formation, gene expression, host-mediated suppression of viral transcription, mRNA processing, negative regulation of gene expression, nuclear inner membrane organization, positive regulation of insulin secretion, positive regulation of protein import into nucleus, regulation of apoptotic process, regulation of cell cycle, regulation of circadian rhythm, regulation of gene expression, regulation of protein stability, response to endoplasmic reticulum stress, rhythmic process; MF: DNA binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, identical protein binding, lipid binding, mRNA 3'-UTR binding, molecular condensate scaffold activity, nucleic acid binding, pre-mRNA intronic binding, protein binding; CC: chromatin, cytoplasm, cytoplasmic stress granule, interchromatin granule, mitochondrion, nuclear speck, nucleoplasm, nucleus, perichromatin fibrils
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q921F2
Entrez ID: 230908
|
Does Knockout of Fgf8 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Fgf8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fgf8 (fibroblast growth factor 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, aorta morphogenesis, blood vessel remodeling, bone development, branching involved in blood vessel morphogenesis, branching involved in salivary gland morphogenesis, branching involved in ureteric bud morphogenesis, cell differentiation, cell fate commitment, cell migration involved in mesendoderm migration, cell proliferation in forebrain, central nervous system neuron development, corticotropin hormone secreting cell differentiation, determination of left/right symmetry, dopaminergic neuron differentiation, dorsal/ventral axon guidance, dorsal/ventral pattern formation, embryo development ending in birth or egg hatching, embryonic heart tube development, embryonic hindlimb morphogenesis, embryonic neurocranium morphogenesis, epithelial to mesenchymal transition involved in endocardial cushion formation, fibroblast growth factor receptor signaling pathway, forebrain dorsal/ventral pattern formation, forebrain morphogenesis, forebrain neuron development, generation of neurons, gonad development, heart development, heart looping, heart morphogenesis, inner ear morphogenesis, kidney development, larynx morphogenesis, limb morphogenesis, lung development, lung morphogenesis, male genitalia development, mesodermal cell migration, mesonephros development, metanephros development, midbrain-hindbrain boundary development, motor neuron axon guidance, negative regulation of apoptotic process, negative regulation of cardiac muscle tissue development, negative regulation of neuron apoptotic process, neural plate morphogenesis, neuroepithelial cell differentiation, neurogenesis, odontogenesis, organ induction, otic vesicle formation, outflow tract morphogenesis, outflow tract septum morphogenesis, pallium development, pharyngeal system development, positive chemotaxis, positive regulation of ERK1 and ERK2 cascade, positive regulation of G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of cell division, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of mitotic nuclear division, positive regulation of organ growth, positive regulation of stem cell proliferation, regulation of cell migration, regulation of odontogenesis of dentin-containing tooth, response to oxidative stress, response to xenobiotic stimulus, signal transduction involved in regulation of gene expression, subpallium development, telencephalon development, thyroid gland development, thyroid-stimulating hormone-secreting cell differentiation; MF: chemoattractant activity, growth factor activity, type 1 fibroblast growth factor receptor binding, type 2 fibroblast growth factor receptor binding; CC: cytoplasm, external side of plasma membrane, extracellular region, extracellular space
Pathways: Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, FGFR1 ligand binding and activation, FGFR1c ligand binding and activation, FGFR2 ligand binding and activation, FGFR2c ligand binding and activation, FGFR3 ligand binding and activation, FGFR3b ligand binding and activation, FGFR3c ligand binding and activation, FGFR4 ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Gastric cancer - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Phospholipase C-mediated cascade: FGFR1, Phospholipase C-mediated cascade; FGFR2, Phospholipase C-mediated cascade; FGFR3, Phospholipase C-mediated cascade; FGFR4, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: P37237
Entrez ID: 14179
|
Does Knockout of Gps2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Gps2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gps2 (G protein pathway suppressor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, negative regulation of B cell receptor signaling pathway, negative regulation of JNK cascade, negative regulation of fat cell differentiation, negative regulation of inflammatory response, negative regulation of protein K63-linked ubiquitination, negative regulation of toll-like receptor signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of cholesterol efflux, positive regulation of peroxisome proliferator activated receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of fat cell differentiation, regulation of lipid metabolic process, regulation of transcription by RNA polymerase II, response to mitochondrial depolarisation; MF: cyclin binding, protein binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), HDACs deacetylate histones, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q921N8
Entrez ID: 56310
|
Does Knockout of Synpo2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Synpo2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Synpo2 (synaptopodin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, chaperone-mediated autophagy, positive regulation of actin filament bundle assembly, positive regulation of cell migration; MF: 14-3-3 protein binding, actin binding, alpha-actinin binding, filamin binding, muscle alpha-actinin binding, protein binding, protein-macromolecule adaptor activity; CC: Z disc, actin cytoskeleton, anchoring junction, cytoplasm, cytosol, focal adhesion, nucleoplasm, nucleus, stress fiber, vesicle tethering complex
Pathways:
UniProt: Q91YE8
Entrez ID: 118449
|
Does Knockout of Rspry1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Rspry1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rspry1 (ring finger and SPRY domain containing 1)
Type: protein-coding
Summary: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in extracellular region. Predicted to be active in cytoplasm. Is expressed in several structures, including forelimb bud; heart; limb; perichondrium; and periosteum. Orthologous to human RSPRY1 (ring finger and SPRY domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: metal ion binding, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, extracellular region
Pathways:
UniProt: Q8BVR6
Entrez ID: 67610
|
Does Knockout of Ecd in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Ecd
|
response to virus
|
Microglial Cell Line
|
Gene: Ecd (ecdysoneless cell cycle regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, fibroblast proliferation, mRNA processing, positive regulation of transcription by RNA polymerase II, regulation of G1/S transition of mitotic cell cycle; MF: histone acetyltransferase binding, protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9CS74
Entrez ID: 70601
|
Does Knockout of Naxd in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Naxd
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Naxd (NAD(P)HX dehydratase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: metabolite repair, nicotinamide nucleotide metabolic process; MF: ATP binding, ATP-dependent NAD(P)H-hydrate dehydratase activity, hydro-lyase activity, lyase activity, nucleotide binding; CC: cytosol, endoplasmic reticulum, mitochondrion
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Nicotinate metabolism
UniProt: Q9CZ42
Entrez ID: 69225
|
Does Knockout of Nek10 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Nek10
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Nek10 (NIMA (never in mitosis gene a)- related kinase 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mucociliary clearance, regulation of ERK1 and ERK2 cascade, regulation of cell cycle G2/M phase transition; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: extracellular region, protein kinase complex
Pathways:
UniProt: Q3UGM2
Entrez ID: 674895
|
Does Knockout of Tmem74b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Tmem74b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tmem74b (transmembrane protein 74B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: A2AU34
Entrez ID: 108832
|
Does Knockout of Trim33 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Trim33
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Trim33 (tripartite motif-containing 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gene expression, negative regulation of BMP signaling pathway, protein ubiquitination, regulation of transforming growth factor beta receptor signaling pathway; MF: DNA binding, R-SMAD binding, co-SMAD binding, metal ion binding, promoter-specific chromatin binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Downregulation of SMAD2/3:SMAD4 transcriptional activity, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
UniProt: Q99PP7
Entrez ID: 94093
|
Does Knockout of Slc25a18 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Slc25a18
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc25a18 (solute carrier family 25 (mitochondrial carrier), member 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-aspartate transmembrane transport, L-glutamate transmembrane transport, aspartate transmembrane transport, malate-aspartate shuttle, proton transmembrane transport, transmembrane transport; MF: L-aspartate transmembrane transporter activity, L-glutamate transmembrane transporter activity, amino acid:proton symporter activity, symporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Malate-aspartate shuttle, Metabolism, Respiratory electron transport, SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Transport of small molecules
UniProt: Q9DB41
Entrez ID: 71803
|
Does Knockout of Lrrtm3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Lrrtm3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Lrrtm3 (leucine rich repeat transmembrane neuronal 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of amyloid-beta formation, positive regulation of synapse assembly, regulation of presynapse assembly; CC: glutamatergic synapse, membrane, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse
Pathways: Neurexins and neuroligins, Neuronal System, Protein-protein interactions at synapses
UniProt: Q8BZ81
Entrez ID: 216028
|
Does Knockout of Slc25a1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,286
|
Knockout
|
Slc25a1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc25a1 (solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial citrate transmembrane transport, negative regulation of ferroptosis, transmembrane transport; MF: antiporter activity, citrate secondary active transmembrane transporter activity, tricarboxylic acid transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways: Organic anion transport by SLC5/17/25 transporters, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: Q8JZU2
Entrez ID: 13358
|
Does Knockout of Prelid1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Prelid1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Prelid1 (PRELI domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, intermembrane lipid transfer, lipid transport, negative regulation of apoptotic process, negative regulation of mitochondrial membrane potential, negative regulation of release of cytochrome c from mitochondria, phospholipid transport, positive regulation of T cell apoptotic process, positive regulation of cellular respiration, positive regulation of endopeptidase activity, positive regulation of phospholipid transport, regulation of T cell differentiation, regulation of membrane lipid distribution, regulation of mitochondrial membrane potential; MF: phosphatidic acid transfer activity; CC: mitochondrial intermembrane space, mitochondrion, nucleoplasm, protein-containing complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53
UniProt: Q8R107
Entrez ID: 66494
|
Does Knockout of Clint1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Clint1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Clint1 (clathrin interactor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: clathrin coat assembly, endocytosis; MF: clathrin binding, lipid binding, phospholipid binding; CC: Golgi apparatus, clathrin vesicle coat, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, endomembrane system, endosome, membrane, nucleoplasm, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q5SUH6, Q5SUH7, Q3UPG6
Entrez ID: 216705
|
Does Knockout of Alg6 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Alg6
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Alg6 (ALG6 alpha-1,3-glucosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein glycosylation; MF: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity, glucosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, dolichyl-diphosphooligosaccharide biosynthesis
UniProt: Q3TAE8
Entrez ID: 320438
|
Does Knockout of Inpp5a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Inpp5a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Inpp5a (inositol polyphosphate-5-phosphatase A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inositol phosphate metabolic process, negative regulation of calcium-mediated signaling, negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway, phosphatidylinositol dephosphorylation; MF: PH domain binding, hydrolase activity, inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity, inositol-polyphosphate 5-phosphatase activity, phosphatase activity; CC: cell projection, dendrite, membrane, plasma membrane
Pathways: D-<i>myo</i>-inositol (1,4,5)-trisphosphate degradation, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Synthesis of IP2, IP, and Ins in the cytosol, superpathway of D-<i>myo</i>-inositol (1,4,5)-trisphosphate metabolism
UniProt: Q7TNC9
Entrez ID: 212111
|
Does Knockout of Nubp2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Nubp2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nubp2 (nucleotide binding protein 2)
Type: protein-coding
Summary: Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly. Located in nucleus and spindle pole centrosome. Is expressed in several structures, including extraembryonic component; genitourinary system; liver; lung; and spleen. Orthologous to human NUBP2 (NUBP iron-sulfur cluster assembly factor 2, cytosolic). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell projection organization, iron-sulfur cluster assembly; MF: 4 iron, 4 sulfur cluster binding, ATP binding, ATP-dependent FeS chaperone activity, iron-sulfur cluster binding, metal ion binding, nucleotide binding, protein binding; CC: cell projection, centriole, centrosome, cilium, cytoplasm, cytoskeleton, cytosol, microtubule organizing center, nucleoplasm, nucleus, spindle pole centrosome
Pathways:
UniProt: Q9R061
Entrez ID: 26426
|
Does Knockout of Nifk in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Nifk
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nifk (nucleolar protein interacting with the FHA domain of MKI67)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: chromosome, condensed nuclear chromosome, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q91VE6
Entrez ID: 67949
|
Does Knockout of Csnk1a1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Csnk1a1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Csnk1a1 (casein kinase 1, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, NLRP3 inflammasome complex assembly, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, TORC1 signaling, Wnt signaling pathway, autophagosome assembly, cell division, cell morphogenesis, cellular response to nutrient, cellular response to nutrient levels, intermediate filament cytoskeleton organization, negative regulation of NLRP3 inflammasome complex assembly, negative regulation of TORC1 signaling, negative regulation of autophagy, negative regulation of canonical Wnt signaling pathway, negative regulation of signal transduction, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of Rho protein signal transduction, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein phosphorylation, signal transduction; MF: ATP binding, kinase activity, magnesium ion binding, nucleotide binding, peptide binding, phosphoprotein binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: beta-catenin destruction complex, cell projection, centrosome, chromosome, chromosome, centromeric region, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, keratin filament, kinetochore, mRNA cleavage and polyadenylation specificity factor complex, nuclear speck, nucleus, ribonucleoprotein complex, spindle
Pathways: Activation of SMO, Alzheimer disease - Mus musculus (mouse), Beta-catenin phosphorylation cascade, Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Degradation of beta-catenin by the destruction complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, G1/S DNA Damage Checkpoints, GLI3 is processed to GLI3R by the proteasome, Gastric cancer - Mus musculus (mouse), Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog signaling pathway - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Signal Transduction, Signaling by Hedgehog, Signaling by WNT, TCF dependent signaling in response to WNT, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Wnt signaling pathway - Mus musculus (mouse), p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q8BK63
Entrez ID: 93687
|
Does Knockout of Tpd52 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Tpd52
|
cell proliferation
|
Regulatory T cell
|
Gene: Tpd52 (tumor protein D52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, positive regulation of cell population proliferation; MF: calcium ion binding, identical protein binding, protein binding, protein homodimerization activity; CC: cytoplasm, endoplasmic reticulum, glutamatergic synapse, perinuclear region of cytoplasm, synapse
Pathways: Golgi Associated Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q62393
Entrez ID: 21985
|
Does Knockout of Igkv5-43 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Igkv5-43
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Igkv5-43 (immunoglobulin kappa chain variable 5-43)
Type: other
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, immune response, immune system process; CC: extracellular region, immunoglobulin complex, plasma membrane
Pathways:
UniProt:
Entrez ID: 381783
|
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