prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Limk1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Limk1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Limk1 (LIM domain kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the LIM kinase family of proteins. This protein is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein also stimulates axon growth and may play a role in brain development. Homozygous knockout mice for this gene exhibit reduced bone mass, abnormal neuronal morphology and altered synaptic function. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: actin cytoskeleton organization, positive regulation of actin filament bundle assembly, positive regulation of axon extension, positive regulation of stress fiber assembly, protein phosphorylation, regulation of modification of postsynaptic actin cytoskeleton; MF: ATP binding, heat shock protein binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, ubiquitin ligase inhibitor activity, ubiquitin protein ligase binding; CC: axonal growth cone, cell junction, cell projection, cytoplasm, cytoskeleton, cytosol, focal adhesion, glutamatergic synapse, lamellipodium, male germ cell nucleus, membrane, neuron projection, nuclear speck, nucleus, perinuclear region of cytoplasm, postsynapse
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Nervous system development, RHO GTPase Effectors, RHO GTPases activate PAKs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Sema3A PAK dependent Axon repulsion, Semaphorin interactions, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Yersinia infection - Mus musculus (mouse)
UniProt: P53668
Entrez ID: 16885
|
Does Knockout of Gsta2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Gsta2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gsta2 (glutathione S-transferase, alpha 2 (Yc2))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutathione metabolic process, response to bacterium, response to stilbenoid, xenobiotic metabolic process; MF: dinitrosyl-iron complex binding, fatty acid binding, glutathione binding, glutathione peroxidase activity, glutathione transferase activity, protein homodimerization activity, steroid Delta-isomerase activity, transferase activity; CC: cytosol, mitochondrion
Pathways: Azathioprine ADME, Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug ADME, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Heme degradation, Hepatocellular carcinoma - Mus musculus (mouse), Metabolism, Metabolism of porphyrins, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: P10648
Entrez ID: 14858
|
Does Knockout of Plscr2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Plscr2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Plscr2 (phospholipid scramblase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to lipopolysaccharide, immune response, phosphatidylserine exposure on apoptotic cell surface, plasma membrane phospholipid scrambling, regulation of Fc receptor mediated stimulatory signaling pathway, regulation of mast cell activation; MF: CD4 receptor binding, DNA-binding transcription activator activity, RNA polymerase II-specific, SH3 domain binding, calcium ion binding, enzyme binding, epidermal growth factor receptor binding, lead ion binding, magnesium ion binding, mercury ion binding, metal ion binding, nuclease activity, phospholipid scramblase activity, protein binding, virus receptor activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum, membrane, membrane raft, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q9DCW2
Entrez ID: 18828
|
Does Knockout of Tsacc in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Tsacc
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tsacc (TSSK6 activating co-chaperone)
Type: protein-coding
Summary: Predicted to enable Hsp70 protein binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Predicted to act upstream of or within positive regulation of protein kinase activity. Located in cytoplasm. Orthologous to human TSACC (TSSK6 activating cochaperone). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: Hsp70 protein binding, protein kinase binding, protein kinase inhibitor activity, protein-folding chaperone binding; CC: cytoplasm
Pathways:
UniProt: Q9DA44
Entrez ID: 76927
|
Does Knockout of Cdc25c in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Cdc25c
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cdc25c (cell division cycle 25C)
Type: protein-coding
Summary: This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, cell division, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of G2/MI transition of meiotic cell cycle, positive regulation of cell cycle G2/M phase transition; MF: WW domain binding, hydrolase activity, phosphoprotein phosphatase activity, protein binding, protein kinase binding, protein serine/threonine kinase binding, protein tyrosine phosphatase activity; CC: cytoplasm, cytosol, mitochondrial intermembrane space, nuclear speck, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, Human immunodeficiency virus 1 infection - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Mitotic G2-G2/M phases, Oocyte meiosis - Mus musculus (mouse), Polo-like kinase mediated events, Progesterone-mediated oocyte maturation - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases activate PKNs, RNA Polymerase II Transcription, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: P48967
Entrez ID: 12532
|
Does Knockout of Fnta in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Fnta
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Fnta (farnesyltransferase, CAAX box, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: enzyme-linked receptor protein signaling pathway, negative regulation of apoptotic process, nuclear envelope organization, peptide pheromone maturation, positive regulation of Rac protein signal transduction, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of skeletal muscle acetylcholine-gated channel clustering, protein farnesylation, protein geranylgeranylation, protein maturation, regulation of microtubule-based movement; MF: CAAX-protein geranylgeranyltransferase activity, Rab geranylgeranyltransferase activity, acetyltransferase activator activity, alpha-tubulin binding, enzyme binding, heterocyclic compound binding, microtubule binding, molecular adaptor activity, peptide binding, prenyltransferase activity, protein farnesyltransferase activity, protein geranylgeranyltransferase activity, protein prenyltransferase activity, receptor tyrosine kinase binding, small molecule binding, transferase activity, zinc ion binding; CC: CAAX-protein geranylgeranyltransferase complex, cytoplasm, microtubule associated complex, protein farnesyltransferase complex
Pathways: Terpenoid backbone biosynthesis - Mus musculus (mouse)
UniProt: Q61239
Entrez ID: 14272
|
Does Knockout of Saa1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Saa1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Saa1 (serum amyloid A 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acute-phase response, cholesterol metabolic process, response to bacterium; MF: G protein-coupled receptor binding, heparin binding, protein binding; CC: cytoplasmic microtubule, extracellular region, extracellular space, high-density lipoprotein particle
Pathways:
UniProt: P05366
Entrez ID: 20208
|
Does Knockout of Zfp414 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Zfp414
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp414 (zinc finger protein 414)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q9DCK4
Entrez ID: 328801
|
Does Knockout of Slc25a1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Slc25a1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc25a1 (solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial citrate transmembrane transport, negative regulation of ferroptosis, transmembrane transport; MF: antiporter activity, citrate secondary active transmembrane transporter activity, tricarboxylic acid transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways: Organic anion transport by SLC5/17/25 transporters, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: Q8JZU2
Entrez ID: 13358
|
Does Knockout of Pcdhgc3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Pcdhgc3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pcdhgc3 (protocadherin gamma subfamily C, 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of neuron apoptotic process, synapse organization; MF: calcium ion binding, cell adhesion molecule binding, metal ion binding; CC: cell-cell junction, membrane, plasma membrane
Pathways:
UniProt: A0A0A6YWM6, Q91XX1
Entrez ID: 93706
|
Does Knockout of Mrpl23 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Mrpl23
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mrpl23 (mitochondrial ribosomal protein L23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: cytosolic ribosome, fibrillar center, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosomal subunit, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: O35972
Entrez ID: 19935
|
Does Knockout of Psmc4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Psmc4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Psmc4 (proteasome (prosome, macropain) 26S subunit, ATPase, 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATP binding, ATP hydrolysis activity, nucleotide binding, proteasome-activating activity; CC: ciliary basal body, cytoplasm, cytosol, cytosolic proteasome complex, inclusion body, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P54775
Entrez ID: 23996
|
Does Knockout of Mc5r in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Mc5r
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Mc5r (melanocortin 5 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of feeding behavior, signal transduction; MF: G protein-coupled receptor activity, hormone binding, melanocortin receptor activity, melanocyte-stimulating hormone receptor activity; CC: cytoplasm, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: P41149
Entrez ID: 17203
|
Does Knockout of Eomes in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Eomes
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eomes (eomesodermin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, alpha-beta T cell differentiation involved in immune response, adaptive immune response, anatomical structure morphogenesis, astrocyte differentiation, blastocyst development, brain development, cardioblast differentiation, cell differentiation, cell differentiation involved in embryonic placenta development, cerebral cortex development, cerebral cortex neuron differentiation, cerebral cortex regionalization, chromatin remodeling, endoderm development, endoderm formation, endodermal cell fate specification, forebrain neuron differentiation, gastrulation, gene expression, immune system process, mesendoderm development, mesoderm formation, mesodermal to mesenchymal transition involved in gastrulation, negative regulation of transcription by RNA polymerase II, neurogenesis, neuron differentiation, neuron migration, olfactory bulb development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II, skeletal muscle cell differentiation, stem cell population maintenance, trophectodermal cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription corepressor activity; CC: chromatin, nucleoplasm, nucleus
Pathways:
UniProt: O54839
Entrez ID: 13813
|
Does Knockout of Rab37 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Rab37
|
phagocytosis
|
macrophage
|
Gene: Rab37 (RAB37, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of autophagy, protein transport, regulation of exocytosis, regulation of eye photoreceptor cell development; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: Golgi apparatus, cell projection, cilium, cytoplasmic vesicle, endoplasmic reticulum-Golgi intermediate compartment, endosome, photoreceptor connecting cilium, secretory granule
Pathways: Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB geranylgeranylation
UniProt: Q9JKM7
Entrez ID: 58222
|
Does Knockout of Prpf3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Prpf3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Prpf3 (pre-mRNA processing factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal tri-snRNP complex assembly; MF: identical protein binding; CC: Cajal body, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, cytosol, nuclear speck, nucleoplasm, nucleus, protein-containing complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q922U1
Entrez ID: 70767
|
Does Knockout of Vps37c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Vps37c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vps37c (vacuolar protein sorting 37C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: macroautophagy, multivesicular body assembly, protein targeting to membrane, protein targeting to vacuole, protein transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, viral budding via host ESCRT complex; MF: calcium-dependent protein binding; CC: ESCRT I complex, Golgi apparatus, cilium, endosome, late endosome membrane, membrane, nucleoplasm
Pathways: Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), Membrane Trafficking, Vesicle-mediated transport
UniProt: Q8R105
Entrez ID: 107305
|
Does Knockout of Ncdn in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Ncdn
|
response to virus
|
Microglial Cell Line
|
Gene: Ncdn (neurochondrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone resorption, neuron projection development, regulation of neuronal synaptic plasticity, regulation of postsynaptic neurotransmitter receptor internalization; CC: axon, cell projection, cytoplasm, cytosol, dendrite, endosome, endosome membrane, glutamatergic synapse, membrane, neuron projection, neuronal cell body, nucleus, perikaryon, postsynapse, synapse
Pathways:
UniProt: Q9Z0E0
Entrez ID: 26562
|
Does Knockout of Phip in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Phip
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Phip (pleckstrin homology domain interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, cytoskeleton organization, insulin receptor signaling pathway, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of fibroblast proliferation, positive regulation of insulin-like growth factor receptor signaling pathway, positive regulation of mitotic nuclear division, positive regulation of transcription by RNA polymerase II, positive regulation of type B pancreatic cell proliferation, protein import into nucleus, regulation of cell morphogenesis, regulation of cell shape, regulation of growth, regulation of protein phosphorylation, regulation of signal transduction, regulation of transcription by RNA polymerase II; MF: histone reader activity, protein binding; CC: nucleus
Pathways:
UniProt: A0A087WP89, F8VQ93, A0A087WPP7, A0A087WR26
Entrez ID: 83946
|
Does Knockout of Psmb1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Psmb1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Psmb1 (proteasome (prosome, macropain) subunit, beta type 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis involved in protein catabolic process; CC: cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: O09061
Entrez ID: 19170
|
Does Knockout of Il18r1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Il18r1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Il18r1 (interleukin 18 receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 1 cell differentiation, adaptive immune response, immune response, inflammatory response, interleukin-18-mediated signaling pathway, natural killer cell activation, negative regulation of cold-induced thermogenesis, positive regulation of NF-kappaB transcription factor activity, positive regulation of T-helper 1 cell cytokine production, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of type II interferon production, signal transduction; MF: NAD+ nucleosidase activity, cyclic ADP-ribose generating, hydrolase activity, interleukin-18 binding, interleukin-18 receptor activity, protein binding; CC: cell surface, interleukin-18 receptor complex, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-1 family signaling, Interleukin-18 signaling, Signaling by Interleukins, TNF signaling pathway - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q61098
Entrez ID: 16182
|
Does Knockout of Mrpl50 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Mrpl50
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mrpl50 (mitochondrial ribosomal protein L50)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytosol, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q8VDT9
Entrez ID: 28028
|
Does Knockout of Dct in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Dct
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Dct (dopachrome tautomerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell development, developmental pigmentation, melanin biosynthetic process, melanin biosynthetic process from tyrosine, pigmentation, positive regulation of neuroblast proliferation, response to blue light, ventricular zone neuroblast division; MF: dopachrome isomerase activity, isomerase activity, metal ion binding, oxidoreductase activity; CC: cytoplasm, cytosol, melanosome, melanosome membrane, membrane, plasma membrane
Pathways: Melanin biosynthesis, Melanogenesis - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Tyrosine metabolism - Mus musculus (mouse), eumelanin biosynthesis
UniProt: P29812
Entrez ID: 13190
|
Does Knockout of Srsf3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Srsf3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Srsf3 (serine and arginine-rich splicing factor 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: RNA processing, RNA splicing, cellular response to leukemia inhibitory factor, insulin receptor signaling pathway, mRNA export from nucleus, mRNA processing, mRNA transport, primary miRNA processing, regulation of alternative mRNA splicing, via spliceosome, regulation of mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding, phospholipase binding, primary miRNA binding, protein binding, protein-RNA sequence-specific adaptor activity, sequence-specific mRNA binding; CC: cytoplasm, nuclear speck, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Gene expression (Transcription), Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P84104
Entrez ID: 20383
|
Does Knockout of Sla in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Sla
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Sla (src-like adaptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of MAPK cascade, signal transduction; MF: epidermal growth factor receptor binding, phosphotyrosine residue binding, protein binding; CC: COP9 signalosome, cytoplasm, endosome, nucleoplasm, plasma membrane
Pathways: Cytokine Signaling in Immune system, FLT3 Signaling, Immune System, Negative regulation of FLT3
UniProt: Q60898
Entrez ID: 20491
|
Does Knockout of Fmo6 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Fmo6
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fmo6 (flavin containing monooxygenase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: taurine biosynthetic process, xenobiotic metabolic process; MF: N,N-dimethylaniline monooxygenase activity, NADP binding, flavin adenine dinucleotide binding, monooxygenase activity, oxidoreductase activity; CC: cellular_component, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Drug metabolism - cytochrome P450 - Mus musculus (mouse), nicotine degradation II
UniProt: A0A0J9YUC0, J3QMN6
Entrez ID: 226565
|
Does Knockout of Tpt1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Tpt1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tpt1 (tumor protein, translationally-controlled 1)
Type: protein-coding
Summary: Enables DNA-binding transcription factor binding activity. Involved in negative regulation of ectoderm development and stem cell population maintenance. Located in nucleoplasm. Is expressed in cerebral cortex ventricular layer; cortical plate; sciatic nerve; and testis. Orthologous to several human genes including TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of ectoderm development, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, response to virus, spermatogenesis, stem cell population maintenance; MF: DNA-binding transcription factor binding, calcium ion binding, protein binding; CC: cytoplasm, cytoplasmic microtubule, cytosol, extracellular space, multivesicular body, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: P63028
Entrez ID: 22070
|
Does Knockout of Vmn2r38 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Vmn2r38
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Vmn2r38 (vomeronasal 2, receptor 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: G3UYA8
Entrez ID: 434110
|
Does Knockout of Snrnp40 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Snrnp40
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Snrnp40 (small nuclear ribonucleoprotein 40 (U5))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, mRNA processing; CC: U2-type catalytic step 2 spliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, cytosol, nuclear speck, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q6PE01
Entrez ID: 66585
|
Does Knockout of Mgat1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Mgat1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mgat1 (mannoside acetylglucosaminyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: UDP-N-acetylglucosamine catabolic process, in utero embryonic development, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; MF: acetylglucosaminyltransferase activity, alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity, glycosyltransferase activity, manganese ion binding, metal ion binding, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, membrane, perinuclear region of cytoplasm
Pathways: Asparagine N-linked glycosylation, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), N-glycan trimming and elongation in the cis-Golgi, Post-translational protein modification, Transport to the Golgi and subsequent modification, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: P27808
Entrez ID: 17308
|
Does Knockout of Fndc8 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Fndc8
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Fndc8 (fibronectin type III domain containing 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D2H8
Entrez ID: 78919
|
Does Knockout of Wars2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Wars2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Wars2 (tryptophanyl tRNA synthetase 2 (mitochondrial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial tryptophanyl-tRNA aminoacylation, positive regulation of angiogenesis, tRNA aminoacylation for protein translation, translation, tryptophanyl-tRNA aminoacylation, vasculogenesis; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, tryptophan-tRNA ligase activity; CC: mitochondrial matrix, mitochondrion, nucleoplasm, plasma membrane
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q9CYK1
Entrez ID: 70560
|
Does Knockout of Chchd10 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Chchd10
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Chchd10 (coiled-coil-helix-coiled-coil-helix domain containing 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inner mitochondrial membrane organization, mitochondrial membrane organization, mitochondrion organization; CC: MICOS complex, mitochondrial intermembrane space, mitochondrion, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse)
UniProt: Q7TNL9
Entrez ID: 103172
|
Does Knockout of Arhgap44 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Arhgap44
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Arhgap44 (Rho GTPase activating protein 44)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: modification of postsynaptic structure, modulation of chemical synaptic transmission, negative regulation of Rac protein signal transduction, negative regulation of filopodium assembly, regulation of GTPase activity, regulation of actin cytoskeleton organization, regulation of dendritic spine morphogenesis, regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane, signal transduction; MF: GTPase activator activity, phospholipid binding, small GTPase binding; CC: cell projection, cytoplasm, dendrite, dendritic spine, endosome, glutamatergic synapse, leading edge membrane, plasma membrane, postsynapse, postsynaptic density, presynapse, presynaptic active zone, recycling endosome, synapse
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q5SSM3
Entrez ID: 216831
|
Does Knockout of Uqcrq in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Uqcrq
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Uqcrq (ubiquinol-cytochrome c reductase, complex III subunit VII)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, cerebellar Purkinje cell layer development, hippocampus development, hypothalamus development, midbrain development, mitochondrial electron transport, ubiquinol to cytochrome c, pons development, pyramidal neuron development, subthalamus development, thalamus development; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex III assembly, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQ69
Entrez ID: 22272
|
Does Knockout of Zfp654 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Zfp654
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Zfp654 (zinc finger protein 654)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q9DAU9
Entrez ID: 72020
|
Does Knockout of Urm1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Urm1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Urm1 (ubiquitin related modifier 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble uridine modification; MF: protein tag activity, sulfur carrier activity; CC: cytoplasm, cytosol, nucleus
Pathways: Sulfur relay system - Mus musculus (mouse)
UniProt: Q9D2P4
Entrez ID: 68205
|
Does Knockout of Neu4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Neu4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Neu4 (sialidase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ganglioside catabolic process, glycoprotein catabolic process, lipid catabolic process, lipid metabolic process, negative regulation of neuron projection development, oligosaccharide catabolic process; MF: exo-alpha-sialidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds; CC: cell projection, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, lysosomal lumen, lysosome, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion, neuron projection, organelle inner membrane, plasma membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Metabolism of proteins, Other glycan degradation - Mus musculus (mouse), Post-translational protein modification, Sialic acid metabolism, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Synthesis of substrates in N-glycan biosythesis
UniProt: Q8BZL1
Entrez ID: 241159
|
Does Knockout of Cct7 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Cct7
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cct7 (chaperonin containing TCP1 subunit 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, identical protein binding, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, chaperonin-containing T-complex, cytoplasm, microtubule, mitochondrion, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, RHOBTB2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P80313
Entrez ID: 12468
|
Does Knockout of Jdp2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Jdp2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Jdp2 (Jun dimerization protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, negative regulation of fat cell differentiation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cAMP response element binding, chromatin binding, double-stranded DNA binding, histone chaperone activity, histone deacetylase binding, leucine zipper domain binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein-containing complex binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, nucleus
Pathways:
UniProt: P97875
Entrez ID: 81703
|
Does Knockout of Mrpl54 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Mrpl54
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Mrpl54 (mitochondrial ribosomal protein L54)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including brain; brown fat; early conceptus; gonad; and skeleton. Orthologous to human MRPL54 (mitochondrial ribosomal protein L54). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CPW3
Entrez ID: 66047
|
Does Knockout of Gm19965 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Gm19965
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm19965 (predicted gene, 19965)
Type: pseudo
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways:
UniProt:
Entrez ID: 100503920
|
Does Knockout of Gatb in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Gatb
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gatb (glutamyl-tRNA amidotransferase subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutaminyl-tRNAGln biosynthesis via transamidation, mitochondrial translation, translation; MF: ATP binding, carbon-nitrogen ligase activity, with glutamine as amido-N-donor, catalytic activity, glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, ligase activity, nucleotide binding; CC: glutamyl-tRNA(Gln) amidotransferase complex, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse)
UniProt: Q99JT1
Entrez ID: 229487
|
Does Knockout of Aadat in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Aadat
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Aadat (aminoadipate aminotransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate metabolic process, L-lysine catabolic process to acetyl-CoA via saccharopine, alpha-amino acid metabolic process, glutamate metabolic process, kynurenine metabolic process; MF: 2-aminoadipate transaminase activity, glycine:2-oxoglutarate aminotransferase activity, kynurenine-glyoxylate transaminase activity, kynurenine-oxoglutarate transaminase activity, methionine-glyoxylate transaminase activity, protein homodimerization activity, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: cytosol, mitochondrial matrix, mitochondrion
Pathways: Lysine catabolism, Lysine degradation - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Tryptophan catabolism, Tryptophan metabolism - Mus musculus (mouse), lysine degradation II
UniProt: Q9WVM8
Entrez ID: 23923
|
Does Knockout of Rnaseh2c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Rnaseh2c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rnaseh2c (ribonuclease H2, subunit C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, mismatch repair; CC: nucleus, ribonuclease H2 complex
Pathways: DNA replication - Mus musculus (mouse)
UniProt: Q9CQ18
Entrez ID: 68209
|
Does Knockout of Cyc1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Cyc1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cyc1 (cytochrome c-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, proton transmembrane transport, response to glucagon; MF: electron transfer activity, heme binding, metal ion binding, protein binding, quinol-cytochrome-c reductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex III assembly, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9D0M3
Entrez ID: 66445
|
Does Knockout of Tubg1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Tubg1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tubg1 (tubulin, gamma 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic spindle organization, microtubule nucleation, microtubule-based process, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle organization, regulation of mitotic nuclear division; MF: GTP binding, identical protein binding, microtubule nucleator activity, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: apical part of cell, cell leading edge, centriole, centrosome, ciliary basal body, cilium, condensed nuclear chromosome, cytoplasm, cytoplasmic microtubule, cytoskeleton, gamma-tubulin complex, gamma-tubulin ring complex, microtubule, microtubule organizing center, mitotic spindle microtubule, neuron projection, non-motile cilium, nucleus, pericentriolar material, polar microtubule, recycling endosome, spindle, spindle microtubule, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Human papillomavirus infection - Mus musculus (mouse), Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: P83887
Entrez ID: 103733
|
Does Knockout of Swap70 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Swap70
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Swap70 (SWA-70 protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament bundle assembly, isotype switching, negative regulation of actin filament depolymerization, negative regulation of cell-cell adhesion mediated by integrin, positive regulation of actin filament bundle assembly, positive regulation of cytosolic calcium ion concentration, positive regulation of mast cell chemotaxis, regulation of actin polymerization or depolymerization, regulation of protein localization, somatic cell DNA recombination; MF: ATP binding, DNA binding, protein binding; CC: actin cytoskeleton, cell projection, cytoplasm, cytoskeleton, lamellipodium, membrane, nucleus, plasma membrane, postsynapse
Pathways: RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6A028
Entrez ID: 20947
|
Does Knockout of Rnf166 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Rnf166
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rnf166 (ring finger protein 166)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, immune system process, innate immune response, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: Q3U9F6
Entrez ID: 68718
|
Does Knockout of Pcdh17 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Pcdh17
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pcdh17 (protocadherin 17)
Type: protein-coding
Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: adult behavior, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of synaptic transmission, presynaptic active zone assembly, regulation of synaptic vesicle clustering, synaptic membrane adhesion; MF: calcium ion binding, cell adhesion molecule binding; CC: GABA-ergic synapse, glutamatergic synapse, membrane, plasma membrane, postsynaptic membrane, presynaptic membrane
Pathways:
UniProt: Q5HZI5, Q3UTP0, E9PXF0
Entrez ID: 219228
|
Does Knockout of Gng7 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Gng7
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gng7 (guanine nucleotide binding protein (G protein), gamma 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, behavioral fear response, locomotory behavior, receptor guanylyl cyclase signaling pathway, regulation of adenylate cyclase activity, signal transduction; MF: G-protein beta-subunit binding; CC: Schaffer collateral - CA1 synapse, heterotrimeric G-protein complex, membrane, parallel fiber to Purkinje cell synapse, plasma membrane, synapse, synaptic vesicle membrane
Pathways: ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of G protein gated Potassium channels, Activation of GABAB receptors, Activation of kainate receptors upon glutamate binding, Adrenaline,noradrenaline inhibits insulin secretion, Alcoholism - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Aquaporin-mediated transport, Beta-catenin independent WNT signaling, Ca2+ pathway, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chaperonin-mediated protein folding, Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Class B/2 (Secretin family receptors), Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Dopaminergic synapse - Mus musculus (mouse), ESR-mediated signaling, Extra-nuclear estrogen signaling, G alpha (12/13) signalling events, G alpha (i) signalling events, G alpha (q) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G beta:gamma signalling through BTK, G beta:gamma signalling through CDC42, G beta:gamma signalling through PI3Kgamma, G beta:gamma signalling through PLC beta, G protein gated Potassium channels, G-protein activation, G-protein beta:gamma signalling, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Mus musculus (mouse), GPCR downstream signalling, GPCR ligand binding, GPER1 signaling, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Glutamatergic synapse - Mus musculus (mouse), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Integration of energy metabolism, Inwardly rectifying K+ channels, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Metabolism, Metabolism of proteins, Morphine addiction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Olfactory transduction - Mus musculus (mouse), Opioid Signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet homeostasis, Potassium Channels, Presynaptic function of Kainate receptors, Prostacyclin signalling through prostacyclin receptor, Protein folding, Ras signaling pathway - Mus musculus (mouse), Regulation of insulin secretion, Relaxin signaling pathway - Mus musculus (mouse), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by WNT, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, Transmission across Chemical Synapses, Transport of small molecules, Vasopressin regulates renal water homeostasis via Aquaporins
UniProt: Q61016
Entrez ID: 14708
|
Does Knockout of AY761185 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
AY761185
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: AY761185 (cDNA sequence AY761185)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, disruption of plasma membrane integrity in another organism, innate immune response; MF: pore-forming activity, protein homodimerization activity; CC: azurophil granule, extracellular region, extracellular space, midbody, secretory granule
Pathways: Alpha-defensins, Antimicrobial peptides, Defensins, Immune System, Innate Immune System, NOD-like receptor signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Staphylococcus aureus infection - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q5ERI8
Entrez ID: 100503970
|
Does Knockout of Ranbp2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Ranbp2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ranbp2 (RAN binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, centrosome localization, cytoplasmic pattern recognition receptor signaling pathway, intracellular glucose homeostasis, mRNA transport, negative regulation of RNA export from nucleus, negative regulation of innate immune response, nuclear export, nucleocytoplasmic transport, protein folding, protein sumoylation, protein transport, regulation of gluconeogenesis, response to amphetamine, toll-like receptor signaling pathway; MF: GTPase activator activity, RNA binding, SUMO ligase activity, SUMO transferase activity, kinase activator activity, metal ion binding, peptidyl-prolyl cis-trans isomerase activity, protein binding, protein-containing complex binding, small GTPase binding, transferase activity, zinc ion binding; CC: SUMO ligase complex, annulate lamellae, cytoplasm, cytoplasmic periphery of the nuclear pore complex, cytosol, membrane, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear pore, nuclear pore cytoplasmic filaments, nuclear pore nuclear basket, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q9ERU9
Entrez ID: 19386
|
Does Knockout of Nop56 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Nop56
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nop56 (NOP56 ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, histone methyltransferase binding, snoRNA binding; CC: box C/D methylation guide snoRNP complex, cytoplasm, fibrillar center, nucleolus, nucleoplasm, nucleus, pre-snoRNP complex, ribonucleoprotein complex, small-subunit processome, sno(s)RNA-containing ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D6Z1
Entrez ID: 67134
|
Does Knockout of Ccdc124 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Ccdc124
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ccdc124 (coiled-coil domain containing 124)
Type: protein-coding
Summary: Predicted to enable transcription coactivator activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in cytosol and plasma membrane. Predicted to be active in nucleus. Orthologous to human CCDC124 (coiled-coil domain containing 124). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, positive regulation of DNA-templated transcription, transcription by RNA polymerase II; CC: centrosome, cytoplasm, cytoskeleton, cytosol, midbody, nucleus, plasma membrane
Pathways:
UniProt: Q9D8X2
Entrez ID: 234388
|
Does Knockout of Lmo3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Lmo3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Lmo3 (LIM domain only 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exploration behavior, negative regulation of ERK1 and ERK2 cascade, positive regulation of fat cell differentiation, positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway, positive regulation of peroxisome proliferator activated receptor signaling pathway, positive regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor binding, metal ion binding, transcription coactivator activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8BZL8
Entrez ID: 109593
|
Does Knockout of Ppa2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ppa2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ppa2 (pyrophosphatase (inorganic) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: diphosphate metabolic process, phosphate-containing compound metabolic process, regulation of mitochondrial membrane potential; MF: hydrolase activity, inorganic diphosphate phosphatase activity, magnesium ion binding, metal ion binding, protein serine/threonine phosphatase activity; CC: cytoplasm, mitochondrion, synapse
Pathways: Metabolism, Metabolism of proteins, Mitochondrial tRNA aminoacylation, Oxidative phosphorylation - Mus musculus (mouse), Pyrophosphate hydrolysis, Translation, tRNA Aminoacylation
UniProt: Q91VM9
Entrez ID: 74776
|
Does Knockout of Espn in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Espn
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Espn (espin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament bundle assembly, actin filament network formation, locomotory behavior, microvillar actin bundle assembly, negative regulation of cytoskeleton organization, parallel actin filament bundle assembly, positive regulation of filopodium assembly, sensory perception of sound; MF: SH3 domain binding, actin binding, actin filament binding, protein binding; CC: actin cytoskeleton, actin-based cell projection, anchoring junction, apical ectoplasmic specialization, brush border, cell projection, cluster of actin-based cell projections, cytoplasm, cytoskeleton, cytosol, dendritic spine, filamentous actin, microvillus, organelle, stereocilium, stereocilium bundle, stereocilium tip, synapse
Pathways:
UniProt: Q9ET47
Entrez ID: 56226
|
Does Knockout of Rhox1 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Rhox1
|
response to virus
|
Microglial Cell Line
|
Gene: Rhox1 (reproductive homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: Q4TU92, B1APN4
Entrez ID: 385343
|
Does Knockout of Parp1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Parp1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Parp1 (poly (ADP-ribose) polymerase family, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP generation from poly-ADP-D-ribose, DNA ADP-ribosylation, DNA damage response, DNA metabolic process, DNA repair, DNA repair-dependent chromatin remodeling, apoptotic process, base-excision repair, behavioral response to cocaine, carbohydrate biosynthetic process, cellular response to UV, cellular response to amyloid-beta, cellular response to insulin stimulus, cellular response to nerve growth factor stimulus, cellular response to oxidative stress, cellular response to oxygen-containing compound, cellular response to superoxide, decidualization, double-strand break repair, double-strand break repair via homologous recombination, immune system process, innate immune response, mitochondrial DNA metabolic process, mitochondrial DNA repair, mitochondrion organization, negative regulation of ATP biosynthetic process, negative regulation of DNA-templated transcription, negative regulation of adipose tissue development, negative regulation of cGAS/STING signaling pathway, negative regulation of innate immune response, negative regulation of interleukin-17 production, negative regulation of telomere maintenance via telomere lengthening, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, elongation, positive regulation of SMAD protein signal transduction, positive regulation of adipose tissue development, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cardiac muscle hypertrophy, positive regulation of double-strand break repair via homologous recombination, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of mitochondrial depolarization, positive regulation of myofibroblast differentiation, positive regulation of necroptotic process, positive regulation of protein localization to nucleus, positive regulation of transcription by RNA polymerase II, protein auto-ADP-ribosylation, protein autoprocessing, protein localization to chromatin, protein localization to site of double-strand break, protein poly-ADP-ribosylation, regulation of base-excision repair, regulation of circadian sleep/wake cycle, non-REM sleep, regulation of growth rate, regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, regulation of protein localization, regulation of single strand break repair, replication fork reversal, signal transduction involved in regulation of gene expression, telomere maintenance, transcription pausing by RNA polymerase II, transforming growth factor beta receptor signaling pathway; MF: DNA binding, NAD DNA ADP-ribosyltransferase activity, NAD binding, NAD+ poly-ADP-ribosyltransferase activity, NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity, NAD+-histone H2BS6 serine ADP-ribosyltransferase activity, NAD+-histone H3S10 serine ADP-ribosyltransferase activity, NAD+-protein mono-ADP-ribosyltransferase activity, NAD+-protein-aspartate ADP-ribosyltransferase activity, NAD+-protein-glutamate ADP-ribosyltransferase activity, NAD+-protein-histidine ADP-ribosyltransferase activity, NAD+-protein-serine ADP-ribosyltransferase activity, NAD+-protein-tyrosine ADP-ribosyltransferase activity, R-SMAD binding, RNA polymerase II-specific DNA-binding transcription factor binding, catalytic activity, chromatin binding, damaged DNA binding, enzyme activator activity, enzyme binding, glycosyltransferase activity, histone deacetylase binding, identical protein binding, metal ion binding, nuclear estrogen receptor binding, nucleosome binding, nucleotidyltransferase activity, protein binding, protein homodimerization activity, protein kinase binding, transcription regulator activator activity, transferase activity, ubiquitin protein ligase binding, zinc ion binding; CC: chromatin, chromosome, cytoplasm, cytosol, mitochondrion, nuclear body, nuclear envelope, nuclear replication fork, nucleolus, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, site of DNA damage, site of double-strand break, transcription regulator complex
Pathways: Apoptosis - Mus musculus (mouse), Base excision repair - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse)
UniProt: A0A0A6YX03, Q921K2, A0A0A6YVX0, A0A0A6YY63
Entrez ID: 11545
|
Does Knockout of Dmxl2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Dmxl2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dmxl2 (Dmx-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, chemical synaptic transmission, corpus callosum development, glucose homeostasis, sensory perception of smell, spermatogenesis, vacuolar acidification; CC: RAVE complex, cytoplasmic vesicle, membrane, neuronal dense core vesicle, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways:
UniProt: Q8BPN8
Entrez ID: 235380
|
Does Knockout of Dusp12 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Dusp12
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dusp12 (dual specificity phosphatase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, kinase binding, metal ion binding, phosphatase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9D0T2
Entrez ID: 80915
|
Does Knockout of Iqgap1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Iqgap1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Iqgap1 (IQ motif containing GTPase activating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, caveola assembly, cell migration, cellular response to calcium ion, cellular response to epidermal growth factor stimulus, cellular response to fibroblast growth factor stimulus, cellular response to platelet-derived growth factor stimulus, epidermal growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway, fibroblast migration, mitotic actomyosin contractile ring assembly actin filament organization, negative regulation of dephosphorylation, neuron projection extension, platelet-derived growth factor receptor signaling pathway, podocyte development, positive regulation of MAPK cascade, positive regulation of dendrite development, positive regulation of focal adhesion assembly, positive regulation of protein localization, positive regulation of vascular associated smooth muscle cell migration, regulation of cytokine production, regulation of mitotic cell cycle, regulation of postsynapse assembly, response to angiotensin; MF: GTPase activator activity, MAP-kinase scaffold activity, S100 protein binding, actin filament binding, calcium ion binding, calmodulin binding, mitogen-activated protein kinase binding, molecular adaptor activity, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding, protein domain specific binding, protein kinase binding, protein phosphatase binding, protein serine/threonine kinase activator activity, protein-containing complex binding, small GTPase binding; CC: actin cytoskeleton, apical plasma membrane, axon, basolateral plasma membrane, cell cortex, cell leading edge, cell-cell junction, cortical actin cytoskeleton, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic side of plasma membrane, focal adhesion, growth cone, lateral plasma membrane, membrane, microtubule, microtubule cytoskeleton, midbody, neuron projection, nucleus, plasma membrane, plasma membrane bounded cell projection, postsynapse, protein-containing complex, ribonucleoprotein complex, ruffle, slit diaphragm
Pathways: Adherens junction - Mus musculus (mouse), Cell-Cell communication, Immune System, Innate Immune System, MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Nephrin family interactions, Neutrophil degranulation, Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate IQGAPs, RHOA GTPase cycle, RHOC GTPase cycle, RHOQ GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9JKF1
Entrez ID: 29875
|
Does Knockout of Ctnnd2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ctnnd2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ctnnd2 (catenin delta 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion, dendritic spine morphogenesis, learning, morphogenesis of a branching structure, neuron projection retraction, positive regulation of axon extension, regulation of canonical Wnt signaling pathway, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of synaptic plasticity, synapse organization; MF: beta-catenin binding, cadherin binding, structural constituent of postsynaptic density; CC: adherens junction, anchoring junction, cell junction, cell projection, cytoplasm, dendrite, glutamatergic synapse, nucleus, organelle, perikaryon, plasma membrane, postsynaptic density
Pathways: Wnt signaling pathway - Mus musculus (mouse)
UniProt: O35927
Entrez ID: 18163
|
Does Knockout of Dennd2d in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Dennd2d
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dennd2d (DENN domain containing 2D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q91VV4
Entrez ID: 72121
|
Does Knockout of Kcnab3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Kcnab3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kcnab3 (potassium voltage-gated channel, shaker-related subfamily, beta member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, regulation of potassium ion transmembrane transport; MF: alcohol dehydrogenase (NADP+) activity, oxidoreductase activity, potassium channel regulator activity, protein binding, transmembrane transporter binding, voltage-gated potassium channel activity; CC: cytoplasm, membrane, monoatomic ion channel complex, voltage-gated potassium channel complex
Pathways:
UniProt: Q8C439, Q8VD73, Q8C7S9
Entrez ID: 16499
|
Does Knockout of Lrrc25 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Lrrc25
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lrrc25 (leucine rich repeat containing 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, canonical NF-kappaB signal transduction, connective tissue replacement involved in inflammatory response wound healing, gene expression, heart development, inflammatory response, response to angiotensin, response to hydrostatic pressure, response to transforming growth factor beta; CC: cytoplasm, cytosol, endoplasmic reticulum, membrane, microtubule cytoskeleton
Pathways:
UniProt: Q8K1T1
Entrez ID: 211228
|
Does Knockout of Ddx39b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Ddx39b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ddx39b (DEAD box helicase 39b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, positive regulation of DNA biosynthetic process, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of translation, positive regulation of vascular associated smooth muscle cell proliferation, spliceosomal complex assembly; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on RNA, ATP-dependent protein binding, RNA binding, RNA helicase activity, U4 snRNA binding, U6 snRNA binding, helicase activity, hydrolase activity, identical protein binding, mRNA binding, nucleic acid binding, nucleotide binding, protein-containing complex binding; CC: U4 snRNP, U6 snRNP, cytoplasm, nuclear matrix, nuclear speck, nucleus, protein-containing complex, spliceosomal complex, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9Z1N5
Entrez ID: 53817
|
Does Knockout of Bpifb4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Bpifb4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Bpifb4 (BPI fold containing family B, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: lipid binding, molecular_function; CC: actin cytoskeleton, cytoplasm, cytosol, extracellular region
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: A2BGH0
Entrez ID: 381399
|
Does Knockout of Eif4a1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Eif4a1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Eif4a1 (eukaryotic translation initiation factor 4A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, positive regulation of transcription by RNA polymerase II, translation, translational initiation; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding, translation initiation factor activity; CC: cytoplasm, cytoplasmic stress granule, cytosol, eukaryotic translation initiation factor 4F complex, membrane, nuclear stress granule, perinuclear region of cytoplasm, plasma membrane
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, Cytokine Signaling in Immune system, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Eukaryotic Translation Initiation, GTP hydrolysis and joining of the 60S ribosomal subunit, ISG15 antiviral mechanism, Immune System, Interferon Signaling, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of RNA, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: P60843
Entrez ID: 13681
|
Does Knockout of Rspo1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rspo1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rspo1 (R-spondin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, male meiotic nuclear division, negative regulation of eating behavior, positive regulation of Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of non-canonical Wnt signaling pathway, regulation of gene expression, regulation of macromolecule metabolic process, regulation of male germ cell proliferation, regulation of receptor internalization; MF: G protein-coupled receptor binding, heparin binding, protein binding, signaling receptor binding; CC: extracellular region, extracellular space, nucleus
Pathways: Regulation of FZD by ubiquitination, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q9Z132
Entrez ID: 192199
|
Does Knockout of Bccip in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Bccip
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Bccip (BRCA2 and CDKN1A interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, establishment of mitotic spindle orientation, microtubule anchoring, microtubule cytoskeleton organization, mitotic spindle assembly, mitotic spindle organization, neuroendocrine cell differentiation; MF: kinase regulator activity, tubulin binding; CC: centriole, centrosome, cytoplasm, cytoskeleton, cytosol, mitotic spindle pole, nuclear cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: Q9CWI3
Entrez ID: 66165
|
Does Knockout of Orm1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Orm1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Orm1 (orosomucoid 1)
Type: protein-coding
Summary: This gene encodes a member of the lipocalin family of proteins. The encoded protein is an abundant acute-phase protein that is synthesized by hepatocytes in response to cytokines during the acute phase response. The encoded protein may regulate inflammation and metabolism. This gene is present in a gene cluster on chromosome 4. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: acute inflammatory response, acute-phase response, regulation of immune system process; CC: extracellular region, extracellular space
Pathways: Hemostasis, Immune System, Innate Immune System, Neutrophil degranulation, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q60590
Entrez ID: 18405
|
Does Knockout of Eif2b5 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Eif2b5
|
response to virus
|
Microglial Cell Line
|
Gene: Eif2b5 (eukaryotic translation initiation factor 2B, subunit 5 epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, astrocyte development, astrocyte differentiation, cytoplasmic translational initiation, hippocampus development, myelination, oligodendrocyte development, ovarian follicle development, positive regulation of apoptotic process, positive regulation of translation, positive regulation of translational initiation, response to endoplasmic reticulum stress, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex, nucleus
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of proteins, Recycling of eIF2:GDP, Translation
UniProt: Q8CHW4
Entrez ID: 224045
|
Does Knockout of Epb41l1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Epb41l1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Epb41l1 (erythrocyte membrane protein band 4.1 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actomyosin structure organization, cortical actin cytoskeleton organization, regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane; MF: actin binding, cytoskeletal protein binding, protein binding, signaling receptor binding, structural molecule activity; CC: cytoplasm, cytoskeleton, cytosol, parallel fiber to Purkinje cell synapse, plasma membrane, postsynapse, postsynaptic density, presynapse, protein-containing complex, synaptic membrane
Pathways: Glutamate binding, activation of AMPA receptors and synaptic plasticity, Neurexins and neuroligins, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Protein-protein interactions at synapses, Trafficking of AMPA receptors, Transmission across Chemical Synapses
UniProt: Q9Z2H5
Entrez ID: 13821
|
Does Knockout of Myh7b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Myh7b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Myh7b (myosin, heavy chain 7B, cardiac muscle, beta)
Type: protein-coding
Summary: This gene encodes a myosin heavy chain. The encoded protein forms a hexamer comprised of two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: regulation of CAMKK-AMPK signaling cascade, regulation of calcium-mediated signaling, regulation of cardiac muscle cell contraction, regulation of cytosolic calcium ion concentration; MF: ATP binding, actin binding, actin filament binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding; CC: cardiac myofibril, cytoplasm, membrane, myofibril, myosin II complex, myosin complex, myosin filament
Pathways:
UniProt: A2AQP0
Entrez ID: 668940
|
Does Knockout of Emg1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Emg1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Emg1 (EMG1 N1-specific pseudouridine methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, methylation, nucleologenesis, rRNA base methylation, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, identical protein binding, methyltransferase activity, rRNA (pseudouridine) methyltransferase activity, rRNA binding, transferase activity; CC: chromosome, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O35130
Entrez ID: 14791
|
Does Knockout of Chrac1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Chrac1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Chrac1 (chromatin accessibility complex 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA-templated DNA replication, chromatin remodeling, nucleosome assembly, regulation of DNA replication; MF: DNA binding, DNA-directed DNA polymerase activity, nucleotidyltransferase activity, protein binding, protein heterodimerization activity, transferase activity; CC: CHRAC, nucleus, pericentric heterochromatin
Pathways:
UniProt: Q9JKP8
Entrez ID: 93696
|
Does Knockout of Ube2i in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Ube2i
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ube2i (ubiquitin-conjugating enzyme E2I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, chromosome segregation, modulation of chemical synaptic transmission, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, nuclear export, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, positive regulation of intracellular steroid hormone receptor signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein modification process, protein sumoylation; MF: ATP binding, HLH domain binding, RING-like zinc finger domain binding, SUMO conjugating enzyme activity, SUMO transferase activity, bHLH transcription factor binding, enzyme binding, ionotropic glutamate receptor binding, nucleotide binding, protein binding, small protein activating enzyme binding, transcription coregulator binding, transferase activity, ubiquitin-protein transferase activity; CC: PML body, SUMO ligase complex, Schaffer collateral - CA1 synapse, cytoplasm, cytosol, dendrite, fibrillar center, glutamatergic synapse, nuclear body, nuclear envelope, nuclear pore, nucleoplasm, nucleus, postsynaptic cytosol, presynaptic cytosol, transferase complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Developmental Biology, Formation of Incision Complex in GG-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, M Phase, MITF-M-regulated melanocyte development, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, MicroRNAs in cancer - Mus musculus (mouse), Mitotic Anaphase, Mitotic Metaphase and Anaphase, NF-kappa B signaling pathway - Mus musculus (mouse), Negative regulation of activity of TFAP2 (AP-2) family transcription factors, Nuclear Envelope (NE) Reassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Nucleotide Excision Repair, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing and activation of SUMO, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, SUMO E3 ligases SUMOylate target proteins, SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA methylation proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of immune response proteins, SUMOylation of intracellular receptors, SUMOylation of nuclear envelope proteins, SUMOylation of transcription cofactors, SUMOylation of transcription factors, SUMOylation of ubiquitinylation proteins, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Ubiquitin mediated proteolysis - Mus musculus (mouse), Vitamin D (calciferol) metabolism
UniProt: P63280
Entrez ID: 22196
|
Does Knockout of Kpna1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Kpna1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Kpna1 (karyopherin subunit alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, postsynapse to nucleus signaling pathway, protein import into nucleus, protein transport, regulation of apoptotic process, regulation of canonical Wnt signaling pathway, satellite cell activation involved in skeletal muscle regeneration, skeletal muscle satellite cell proliferation, skeletal muscle tissue regeneration; MF: nuclear import signal receptor activity, nuclear localization sequence binding, protein binding; CC: NLS-dependent protein nuclear import complex, cytoplasm, cytosol, dendrite, glutamatergic synapse, nucleoplasm, nucleus, postsynaptic density
Pathways: Apoptosis, Apoptosis induced DNA fragmentation, Apoptotic execution phase, Assembly of the ORC complex at the origin of replication, Assembly of the pre-replicative complex, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, Nucleocytoplasmic transport - Mus musculus (mouse), Programmed Cell Death, Salmonella infection - Mus musculus (mouse)
UniProt: Q60960
Entrez ID: 16646
|
Does Knockout of Cnnm3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Cnnm3
|
cell cycle progression
|
breast epithelium
|
Gene: Cnnm3 (cyclin M3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: magnesium ion homeostasis, monoatomic ion transport, transmembrane transport; CC: membrane, plasma membrane
Pathways:
UniProt: Q32NY4
Entrez ID: 94218
|
Does Knockout of Rimkla in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Rimkla
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rimkla (ribosomal modification protein rimK-like family member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, N-acetyl-L-aspartate-L-glutamate ligase activity, ligase activity, metal ion binding, nucleotide binding; CC: cytoplasm
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Glutamate and glutamine metabolism, Metabolism, Metabolism of amino acids and derivatives
UniProt: Q6PFX8
Entrez ID: 194237
|
Does Knockout of Casp14 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Casp14
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Casp14 (caspase 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, positive regulation of neuron apoptotic process, proteolysis; MF: cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: cornified envelope, cytoplasm, cytosol, keratin filament, mitochondrion, nucleoplasm, nucleus
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: O89094
Entrez ID: 12365
|
Does Knockout of Myo5c in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Myo5c
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Myo5c (myosin VC)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, endocytosis, establishment of secretory granule localization, phenol-containing compound metabolic process, pigmentation, protein transport, secretory granule localization, vesicle transport along actin filament; MF: ATP binding, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding; CC: Schaffer collateral - CA1 synapse, actin cytoskeleton, actomyosin, cytoplasm, membrane, myosin complex, secretory granule
Pathways:
UniProt: A0A1L1SUF0, E9Q1F5
Entrez ID: 208943
|
Does Knockout of Ttll11 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Ttll11
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Ttll11 (tubulin tyrosine ligase-like family, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, microtubule severing; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, protein-glutamic acid ligase activity, elongating, protein-glutamic acid ligase activity, initiating, tubulin binding, tubulin-glutamic acid ligase activity; CC: cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: A4Q9F4
Entrez ID: 74410
|
Does Knockout of Serpina3j in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Serpina3j
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Serpina3j (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: serine-type endopeptidase inhibitor activity; CC: extracellular space
Pathways:
UniProt: D3Z451
Entrez ID: 238395
|
Does Knockout of Rab3il1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Rab3il1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rab3il1 (RAB3A interacting protein (rabin3)-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, identical protein binding, kinase binding
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q8VDV3
Entrez ID: 74760
|
Does Knockout of Wdr45 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Wdr45
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Wdr45 (WD repeat domain 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, autophagy of mitochondrion, cellular response to starvation, glycophagy, nucleophagy, pexophagy, positive regulation of autophagosome assembly, protein localization to phagophore assembly site; MF: lipid binding, phosphatidylinositol phosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, protein kinase binding, protein-macromolecule adaptor activity; CC: cytoplasm, cytosol, phagophore assembly site, phagophore assembly site membrane
Pathways: Autophagy, Macroautophagy
UniProt: Q91VM3
Entrez ID: 54636
|
Does Knockout of A4galt in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
A4galt
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: A4galt (alpha 1,4-galactosyltransferase)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010].
Gene Ontology: BP: globoside biosynthetic process, glycosphingolipid biosynthetic process, lipid metabolic process, plasma membrane organization; MF: galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, lactosylceramide 4-alpha-galactosyltransferase activity, toxic substance binding, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - globo and isoglobo series - Mus musculus (mouse), Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Sphingolipid metabolism
UniProt: Q67BJ4
Entrez ID: 239559
|
Does Knockout of Wfdc12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Wfdc12
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Wfdc12 (WAP four-disulfide core domain 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, defense response to bacterium, innate immune response; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9JHY3
Entrez ID: 192200
|
Does Knockout of Hdac3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,171
|
Knockout
|
Hdac3
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Hdac3 (histone deacetylase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair-dependent chromatin remodeling, cellular response to fluid shear stress, cellular response to mechanical stimulus, cellular response to parathyroid hormone stimulus, chromatin organization, circadian regulation of gene expression, cornified envelope assembly, epidermis development, epigenetic regulation of gene expression, establishment of mitotic spindle orientation, establishment of skin barrier, gene expression, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of JNK cascade, negative regulation of cardiac muscle cell differentiation, negative regulation of ferroptosis, negative regulation of interleukin-1 production, negative regulation of protein export from nucleus, negative regulation of transcription by RNA polymerase II, negative regulation of tumor necrosis factor production, neural precursor cell proliferation, positive regulation of TOR signaling, positive regulation of cold-induced thermogenesis, positive regulation of ferroptosis, positive regulation of neuron apoptotic process, positive regulation of protein import into nucleus, positive regulation of protein phosphorylation, positive regulation of protein ubiquitination, positive regulation of transcription by RNA polymerase II, positive regulation of type B pancreatic cell apoptotic process, random inactivation of X chromosome, regulation of circadian rhythm, regulation of mitotic cell cycle, regulation of multicellular organism growth, regulation of protein stability, response to dexamethasone, response to nutrient levels, response to xenobiotic stimulus, rhythmic process, spindle assembly; MF: DNA binding, DNA-binding transcription factor binding, GTPase binding, NF-kappaB binding, chromatin DNA binding, chromatin binding, cyclin binding, deacetylase activity, enzyme binding, histone deacetylase activity, histone deacetylase activity, hydrolytic mechanism, histone deacetylase binding, histone decrotonylase activity, hydrolase activity, metal ion binding, protein binding, protein de-2-hydroxyisobutyrylase activity, protein decrotonylase activity, protein lysine deacetylase activity, protein lysine delactylase activity, transcription corepressor activity, transcription corepressor binding, ubiquitin-specific protease binding; CC: Golgi apparatus, chromatin, chromosome, cytoplasm, cytosol, histone deacetylase complex, mitotic spindle, nucleoplasm, nucleus, plasma membrane, transcription repressor complex
Pathways: Adipogenesis, Alcoholism - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Cytoprotection by HMOX1, Developmental Biology, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Neutrophil extracellular trap formation - Mus musculus (mouse), Notch-HLH transcription pathway, RNA Polymerase II Transcription, Regulation of lipid metabolism by PPARalpha, STAT3 nuclear events downstream of ALK signaling, Signal Transduction, Signaling by ALK, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional regulation of white adipocyte differentiation, Viral carcinogenesis - Mus musculus (mouse)
UniProt: O88895
Entrez ID: 15183
|
Does Knockout of Zbtb46 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Zbtb46
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zbtb46 (zinc finger and BTB domain containing 46)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of dendritic cell differentiation, negative regulation of granulocyte differentiation, negative regulation of leukocyte activation, negative regulation of macrophage differentiation, negative regulation of monocyte differentiation, negative regulation of transcription by RNA polymerase II, plasmacytoid dendritic cell differentiation, positive regulation of dendritic cell differentiation, regulation of transcription by RNA polymerase II, regulatory T cell differentiation, tolerance induction in gut-associated lymphoid tissue; MF: DNA-binding transcription repressor activity, RNA polymerase II-specific, metal ion binding, protein binding, transcription cis-regulatory region binding, transcription coregulator activity, zinc ion binding; CC: chromatin, nucleus
Pathways:
UniProt: Q8BID6
Entrez ID: 72147
|
Does Knockout of Mesp1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Mesp1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mesp1 (mesoderm posterior 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, cardiac atrium formation, cardiac cell fate determination, cardiac muscle cell differentiation, cardiac vascular smooth muscle cell differentiation, cardiac ventricle formation, cardioblast anterior-lateral migration, cardioblast migration, cardioblast migration to the midline involved in heart field formation, embryonic heart tube morphogenesis, endothelial cell differentiation, gastrulation, gene expression, growth involved in heart morphogenesis, heart induction, heart looping, heart morphogenesis, lateral mesoderm development, mesoderm formation, mesodermal cell migration, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, negative regulation of endodermal cell fate specification, negative regulation of mesodermal cell fate specification, neurogenesis, positive regulation of DNA-templated transcription, positive regulation of Notch signaling pathway, positive regulation of hepatocyte differentiation, positive regulation of striated muscle cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, secondary heart field specification, signal transduction involved in regulation of gene expression, sinoatrial node cell differentiation, sinus venosus morphogenesis, somite rostral/caudal axis specification; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, protein dimerization activity, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: P97309
Entrez ID: 17292
|
Does Knockout of Ino80 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ino80
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ino80 (INO80 complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA recombination, DNA repair, DNA-templated transcription, UV-damage excision repair, cell division, cellular response to UV, cellular response to ionizing radiation, chromatin remodeling, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, mitotic sister chromatid segregation, positive regulation of DNA metabolic process, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of cell growth, positive regulation of nuclear cell cycle DNA replication, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, spindle assembly, telomere maintenance; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent chromatin remodeler activity, DNA binding, actin binding, alpha-tubulin binding, histone binding, hydrolase activity, nucleotide binding; CC: Ino80 complex, chromosome, cytoplasm, cytoskeleton, cytosol, microtubule, nuclear body, nucleoplasm, nucleus, spindle
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q6ZPV2
Entrez ID: 68142
|
Does Knockout of Dennd2c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Dennd2c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dennd2c (DENN domain containing 2C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity
Pathways:
UniProt: G3UYA7, E9Q4E4
Entrez ID: 329727
|
Does Knockout of Tro in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Tro
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Tro (trophinin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell growth, negative regulation of transcription by RNA polymerase II; CC: cytoplasm, nucleus, plasma membrane
Pathways:
UniProt: E9Q886, Q6DIC6, E9Q160, E9Q098, A2AFN3, E9Q1Q4, E9Q1E1
Entrez ID: 56191
|
Does Knockout of Dram1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Dram1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dram1 (DNA-damage regulated autophagy modulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, autophagy, cellular response to oxygen-glucose deprivation, regulation of autophagy; CC: cytoplasm, lysosomal membrane, lysosome, membrane
Pathways:
UniProt: Q9DC58
Entrez ID: 71712
|
Does Knockout of D030028A08Rik in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
D030028A08Rik
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: D030028A08Rik (RIKEN cDNA D030028A08 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 319371
|
Does Knockout of Tbc1d10a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Tbc1d10a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tbc1d10a (TBC1 domain family, member 10a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of proteolysis, retrograde transport, endosome to Golgi; MF: GTPase activator activity, PDZ domain binding, guanyl-nucleotide exchange factor activity; CC: cell projection, cytosol, microvillus, plasma membrane
Pathways: Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: P58802
Entrez ID: 103724
|
Does Knockout of Vmn2r103 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Vmn2r103
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Vmn2r103 (vomeronasal 2, receptor 103)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: E9PWW0
Entrez ID: 627636
|
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