prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Chrnb2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Chrnb2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Chrnb2 (cholinergic receptor nicotinic beta 2 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, acetylcholine receptor signaling pathway, associative learning, behavioral response to nicotine, calcium ion transport, central nervous system neuron axonogenesis, central nervous system projection neuron axonogenesis, chemical synaptic transmission, cognition, conditioned taste aversion, establishment of localization in cell, excitatory postsynaptic potential, lateral geniculate nucleus development, learning, locomotory behavior, membrane depolarization, memory, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of neuronal action potential, nervous system process, neuronal action potential, optic nerve morphogenesis, positive regulation of B cell proliferation, positive regulation of dopamine secretion, positive regulation of synaptic transmission, dopaminergic, presynaptic modulation of chemical synaptic transmission, regulation of circadian sleep/wake cycle, REM sleep, regulation of circadian sleep/wake cycle, non-REM sleep, regulation of dendrite morphogenesis, regulation of dopamine metabolic process, regulation of dopamine secretion, regulation of membrane potential, regulation of postsynaptic membrane potential, regulation of synapse assembly, regulation of synaptic transmission, dopaminergic, regulation of transmission of nerve impulse, response to acetylcholine, response to cocaine, response to ethanol, response to hypoxia, response to nicotine, sensory perception of pain, sensory perception of sound, signal transduction, smooth muscle contraction, social behavior, synaptic transmission involved in micturition, synaptic transmission, cholinergic, vestibulocochlear nerve development, visual learning, visual perception; MF: acetylcholine binding, acetylcholine receptor activity, acetylcholine-gated monoatomic cation-selective channel activity, extracellular ligand-gated monoatomic ion channel activity, heterocyclic compound binding, monoatomic ion channel activity, protein binding, protein-containing complex binding, quaternary ammonium group binding, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: acetylcholine-gated channel complex, cation channel complex, cholinergic synapse, dopaminergic synapse, external side of plasma membrane, membrane, neuron projection, neurotransmitter receptor complex, plasma membrane, plasma membrane raft, postsynaptic membrane, postsynaptic specialization membrane, presynaptic membrane, protein-containing complex, synapse, synaptic membrane
Pathways: Acetylcholine binding and downstream events, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Highly calcium permeable nicotinic acetylcholine receptors, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors, Highly sodium permeable postsynaptic acetylcholine nicotinic receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Mus musculus (mouse), Postsynaptic nicotinic acetylcholine receptors, Presynaptic nicotinic acetylcholine receptors, Transmission across Chemical Synapses
UniProt: Q9ERK7
Entrez ID: 11444
|
Does Knockout of Pdcd5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Pdcd5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Pdcd5 (programmed cell death 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to transforming growth factor beta stimulus, negative regulation of protein folding, positive regulation of apoptotic process, positive regulation of gene expression, regulation of apoptotic process; MF: DNA binding, acetyltransferase activator activity, beta-tubulin binding, heparin binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: P56812
Entrez ID: 56330
|
Does Knockout of Rfx5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Rfx5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rfx5 (regulatory factor X, 5 (influences HLA class II expression))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of MHC class II biosynthetic process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription coregulator binding; CC: RNA polymerase II transcription regulator complex, nucleoplasm, nucleus
Pathways: Antigen processing and presentation - Mus musculus (mouse), Primary immunodeficiency - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q9JL61
Entrez ID: 53970
|
Does Knockout of Xrcc6 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Xrcc6
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Xrcc6 (X-ray repair complementing defective repair in Chinese hamster cells 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, V(D)J recombination, activation of innate immune response, cellular hyperosmotic salinity response, cellular response to X-ray, cellular response to gamma radiation, double-strand break repair, double-strand break repair via classical nonhomologous end joining, double-strand break repair via nonhomologous end joining, immune system process, innate immune response, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of immune system process, positive regulation of lymphocyte differentiation, positive regulation of neurogenesis, positive regulation of transcription by RNA polymerase II, recombinational repair, regulation of smooth muscle cell proliferation, response to ionizing radiation, telomere maintenance; MF: 5'-deoxyribose-5-phosphate lyase activity, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, DNA binding, DNA end binding, DNA helicase activity, catalytic activity, cyclin binding, damaged DNA binding, double-stranded DNA binding, double-stranded telomeric DNA binding, helicase activity, hydrolase activity, lyase activity, nucleotide binding, protein binding, protein-containing complex binding, scaffold protein binding, telomeric DNA binding, transcription cis-regulatory region binding; CC: DNA-dependent protein kinase complex, DNA-dependent protein kinase-DNA ligase 4 complex, Ku70:Ku80 complex, chromosome, cytoplasm, nonhomologous end joining complex, nucleolus, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, transcription regulator complex
Pathways: DNA Double-Strand Break Repair, DNA Repair, Immune System, Innate Immune System, Neutrophil degranulation, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ)
UniProt: P23475
Entrez ID: 14375
|
Does Knockout of Dst in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Dst
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dst (dystonin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, cell adhesion, cell motility, cytoplasmic microtubule organization, cytoskeleton organization, hemidesmosome assembly, intermediate filament cytoskeleton organization, intracellular transport, maintenance of cell polarity, microtubule cytoskeleton organization, regulation of microtubule polymerization or depolymerization, response to wounding, retrograde axonal transport, wound healing; MF: actin binding, calcium ion binding, integrin binding, metal ion binding, microtubule binding, microtubule plus-end binding, protein binding, protein homodimerization activity, structural molecule activity; CC: H zone, Z disc, actin cytoskeleton, anchoring junction, axon, axon cytoplasm, cell cortex, cell leading edge, cell periphery, cell projection, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, focal adhesion, hemidesmosome, intercalated disc, intermediate filament, intermediate filament cytoskeleton, membrane, microtubule, microtubule cytoskeleton, microtubule plus-end, neurofilament cytoskeleton, nuclear envelope, nucleoplasm, nucleus, perinuclear endoplasmic reticulum, perinuclear region of cytoplasm, plasma membrane, polymeric cytoskeletal fiber, postsynaptic density, sarcolemma, stress fiber, type III intermediate filament
Pathways: Cell junction organization, Cell-Cell communication, RHO GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, RND1 GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Type I hemidesmosome assembly
UniProt: Q91ZU6
Entrez ID: 13518
|
Does Knockout of Tex38 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Tex38
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tex38 (testis expressed 38)
Type: protein-coding
Summary: Predicted to be located in membrane. Is expressed in lung. Orthologous to human TEX38 (testis expressed 38). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: MF: molecular_function, protein binding; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: A2A8T7
Entrez ID: 75173
|
Does Knockout of Naca in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Naca
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Naca (nascent polypeptide-associated complex alpha polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: myoblast migration, negative regulation of protein localization to endoplasmic reticulum, positive regulation of DNA-templated transcription, protein targeting to membrane; MF: DNA binding, TBP-class protein binding, transcription coactivator activity, unfolded protein binding; CC: cytoplasm, nascent polypeptide-associated complex, nucleus
Pathways: Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse)
UniProt: Q60817, P70670
Entrez ID: 17938
|
Does Knockout of Slc17a2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Slc17a2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Slc17a2 (solute carrier family 17 (sodium phosphate), member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, sodium ion transport, transmembrane transport, urate transport; MF: symporter activity, transmembrane transporter activity, urate transmembrane transporter activity; CC: apical plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q5SZA1
Entrez ID: 218103
|
Does Knockout of Gtf2b in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Gtf2b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gtf2b (general transcription factor IIB)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase II core complex assembly, RNA polymerase II preinitiation complex assembly, chromatin remodeling, chromosome organization, gene expression, meiotic sister chromatid cohesion, protein acetylation, spindle assembly, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription preinitiation complex assembly, transcriptional start site selection at RNA polymerase II promoter, viral transcription; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase II complex binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, acetyltransferase activity, acyltransferase activity, histone acetyltransferase activity, metal ion binding, nuclear thyroid hormone receptor binding, promoter-specific chromatin binding, protein binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: RNA polymerase II transcription regulator complex, cell division site, chromosome, condensed chromosome, germinal vesicle, kinetochore, nuclear body, nucleoplasm, nucleus, protein-DNA complex, transcription factor TFIID complex, transcription preinitiation complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Spinocerebellar ataxia - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: P62915
Entrez ID: 229906
|
Does Knockout of Appl1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Appl1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Appl1 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adiponectin-activated signaling pathway, cellular response to hepatocyte growth factor stimulus, insulin receptor signaling pathway, maintenance of synapse structure, negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis, positive regulation of D-glucose import, positive regulation of biosynthetic process, positive regulation of cytokine production involved in inflammatory response, positive regulation of macropinocytosis, positive regulation of melanin biosynthetic process, protein import into nucleus, regulation of D-glucose import, regulation of Fc-gamma receptor signaling pathway involved in phagocytosis, regulation of G1/S transition of mitotic cell cycle, regulation of cytokine production involved in inflammatory response, regulation of fibroblast migration, regulation of innate immune response, regulation of phagocytosis, regulation of protein localization to plasma membrane, regulation of toll-like receptor 4 signaling pathway, signaling, transforming growth factor beta receptor signaling pathway; MF: beta-tubulin binding, identical protein binding, phosphatidylinositol binding, phosphatidylserine binding, protein binding, protein homodimerization activity, protein kinase B binding, protein-containing complex binding; CC: actin cytoskeleton, cell projection, cytoplasm, cytoplasmic vesicle, cytosol, early endosome, early endosome membrane, early phagosome, endosome, endosome membrane, glutamatergic synapse, intracellular vesicle, macropinosome, membrane, nucleus, phagocytic vesicle, plasma membrane, postsynapse, presynapse, ruffle, vesicle membrane
Pathways: Colorectal cancer - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: Q8K3H0
Entrez ID: 72993
|
Does Knockout of Pcgf6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Pcgf6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pcgf6 (polycomb group ring finger 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: metal ion binding, protein binding, protein domain specific binding, zinc ion binding; CC: PRC1 complex, PcG protein complex, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Transcriptional Regulation by E2F6
UniProt: Q99NA9
Entrez ID: 71041
|
Does Knockout of Mrpl45 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Mrpl45
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrpl45 (mitochondrial ribosomal protein L45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D0Q7
Entrez ID: 67036
|
Does Knockout of Dad1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Dad1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Dad1 (defender against cell death 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, blastocyst development, negative regulation of apoptotic process, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, regulation of protein stability; MF: enzyme activator activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, N-Glycan biosynthesis - Mus musculus (mouse), PD-L1(CD274) glycosylation and translocation to plasma membrane, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: P61804
Entrez ID: 13135
|
Does Knockout of Pds5a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Pds5a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pds5a (PDS5 cohesin associated factor A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, cell division, embryonic skeletal system morphogenesis, enteric nervous system development, heart morphogenesis, lens development in camera-type eye, metanephros development, mitotic sister chromatid cohesion, negative regulation of DNA replication, neuroblast migration, roof of mouth development; CC: chromatin, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: A0A0J9YV33, E9QPI5
Entrez ID: 71521
|
Does Knockout of Mapk11 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Mapk11
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Mapk11 (mitogen-activated protein kinase 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, NLRP1 inflammasome complex assembly, bone development, cellular response to UV-B, cellular response to interleukin-1, cellular response to virus, intracellular signal transduction, negative regulation of cardiac muscle cell proliferation, osteoblast differentiation, p38MAPK cascade, positive regulation of gene expression, positive regulation of interleukin-12 production, protein maturation, pyroptotic inflammatory response, regulation of cardiac muscle cell proliferation, stress-activated MAPK cascade, stress-activated protein kinase signaling cascade; MF: ATP binding, MAP kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Activation of the AP-1 family of transcription factors, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), ERK/MAPK targets, Epstein-Barr virus infection - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G1/S DNA Damage Checkpoints, Gene expression (Transcription), Generic Transcription Pathway, GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Innate Immune System, Interleukin-17 signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), MAPK targets/ Nuclear events mediated by MAP kinases, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Myogenesis, NOD-like receptor signaling pathway - Mus musculus (mouse), NOD1/2 Signaling Pathway, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Nuclear Events (kinase and transcription factor activation), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oocyte meiosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Oxidative Stress Induced Senescence, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, RIG-I-like receptor signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Rap1 signaling pathway - Mus musculus (mouse), Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Relaxin signaling pathway - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Signalling to ERKs, Signalling to RAS, Sphingolipid signaling pathway - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Transcriptional Regulation by TP53, Tuberculosis - Mus musculus (mouse), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Yersinia infection - Mus musculus (mouse), activated TAK1 mediates p38 MAPK activation, p38MAPK events, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9WUI1
Entrez ID: 19094
|
Does Knockout of Krt1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Krt1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Krt1 (keratin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: complement activation, lectin pathway, establishment of skin barrier, intermediate filament organization, keratinization, negative regulation of inflammatory response, protein heterotetramerization; MF: carbohydrate binding, protein binding, protein heterodimerization activity, structural constituent of skin epidermis; CC: cornified envelope, cytoplasm, intermediate filament, keratin filament, membrane, plasma membrane
Pathways: Developmental Biology, Formation of the cornified envelope, Immune System, Innate Immune System, Keratinization, Neutrophil degranulation
UniProt: P04104
Entrez ID: 16678
|
Does Knockout of Zfp318 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Zfp318
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zfp318 (zinc finger protein 318)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiotic cell cycle, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription; MF: metal ion binding, nucleic acid binding, protein binding, protein heterodimerization activity, protein homodimerization activity, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q99PP2
Entrez ID: 57908
|
Does Knockout of Kctd9 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Kctd9
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Kctd9 (potassium channel tetramerisation domain containing 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NK T cell lineage commitment, biological_process, cell maturation, gene expression, intracellular signal transduction, natural killer cell degranulation, natural killer cell differentiation, natural killer cell proliferation, protein homooligomerization, protein ubiquitination, response to tumor cell, response to virus; MF: cullin family protein binding, identical protein binding, molecular_function
Pathways:
UniProt: Q80UN1
Entrez ID: 105440
|
Does Knockout of Ppp4r2 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,551
|
Knockout
|
Ppp4r2
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Ppp4r2 (protein phosphatase 4, regulatory subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, hematopoietic progenitor cell differentiation, mRNA processing, regulation of double-strand break repair, regulation of double-strand break repair via homologous recombination; MF: protein binding, protein phosphatase regulator activity, protein-macromolecule adaptor activity; CC: centrosome, chromatin, cytoplasm, cytoskeleton, nucleoplasm, nucleus, protein phosphatase 4 complex
Pathways: DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends
UniProt: Q0VGB7
Entrez ID: 232314
|
Does Knockout of Cdc45 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Cdc45
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Cdc45 (cell division cycle 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA replication initiation, double-strand break repair via break-induced replication, mitotic DNA replication preinitiation complex assembly; MF: DNA replication origin binding, chromatin binding, single-stranded DNA binding; CC: CMG complex, DNA replication preinitiation complex, centrosome, ciliary basal body, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition
UniProt: Q9Z1X9
Entrez ID: 12544
|
Does Knockout of Pea15a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Pea15a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pea15a (proliferation and apoptosis adaptor protein 15A)
Type: protein-coding
Summary: This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: MAPK cascade, apoptotic process, intracellular signal transduction, negative regulation of D-glucose import, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, regulation of apoptotic process; CC: cytoplasm, cytosol, microtubule associated complex, nucleoplasm
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, Signal Transduction
UniProt: Q62048
Entrez ID: 18611
|
Does Knockout of Prcd in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Prcd
|
response to virus
|
Microglial Cell Line
|
Gene: Prcd (photoreceptor disc component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: opsin binding; CC: Golgi apparatus, cell projection, cytoplasm, endoplasmic reticulum, extracellular region, membrane, photoreceptor outer segment, photoreceptor outer segment membrane
Pathways:
UniProt: Q00LT2
Entrez ID: 100038570
|
Does Knockout of Sgta in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Sgta
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sgta (small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, negative regulation of ERAD pathway, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of ERAD pathway, positive regulation of ubiquitin-dependent protein catabolic process, post-translational protein targeting to endoplasmic reticulum membrane, protein folding, protein heterooligomerization, protein homooligomerization, tail-anchored membrane protein insertion into ER membrane; MF: BAT3 complex binding, identical protein binding, molecular adaptor activity, protein heterodimerization activity, protein homodimerization activity; CC: TRC complex, cytoplasm, cytosol, extrinsic component of synaptic vesicle membrane, membrane, nucleoplasm, nucleus, presynapse
Pathways: Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, Protein localization
UniProt: Q8BJU0
Entrez ID: 52551
|
Does Knockout of D630023F18Rik in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
D630023F18Rik
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: D630023F18Rik (RIKEN cDNA D630023F18 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C3M9
Entrez ID: 98303
|
Does Knockout of Mtf1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Mtf1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mtf1 (metal response element binding transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, cartilage homeostasis, cellular response to zinc ion, central nervous system development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, response to cadmium ion, response to metal ion, response to oxidative stress; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, histone acetyltransferase binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q07243
Entrez ID: 17764
|
Does Knockout of Nfxl1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Nfxl1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nfxl1 (nuclear transcription factor, X-box binding-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: membrane, nucleus
Pathways:
UniProt: Q3ULV1, E9Q8I7, E9Q3K1, E9PZN0
Entrez ID: 100978
|
Does Knockout of H13 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
H13
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: H13 (histocompatibility 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: in utero embryonic development, membrane protein proteolysis, membrane protein proteolysis involved in retrograde protein transport, ER to cytosol, proteolysis, signal peptide processing; MF: aspartic endopeptidase activity, intramembrane cleaving, hydrolase activity, peptidase activity, protein homodimerization activity, ubiquitin protein ligase binding; CC: Derlin-1 retrotranslocation complex, cell surface, cytoplasmic side of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, lumenal side of endoplasmic reticulum membrane, membrane, organelle membrane, plasma membrane, rough endoplasmic reticulum
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Regulation of HMOX1 expression and activity
UniProt: Q9D8V0
Entrez ID: 14950
|
Does Knockout of Clpsl2 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Clpsl2
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Clpsl2 (colipase-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: digestion, lipid catabolic process, response to food; CC: cellular_component, extracellular region
Pathways:
UniProt: Q3UW21
Entrez ID: 328788
|
Does Knockout of Taar3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Taar3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Taar3 (trace amine-associated receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled amine receptor activity, G protein-coupled receptor activity, trace-amine receptor activity; CC: membrane, plasma membrane
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q5QD16
Entrez ID: 493809
|
Does Knockout of Zfp382 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Zfp382
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp382 (zinc finger protein 382)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, zinc ion binding
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: B2RXC5
Entrez ID: 233060
|
Does Knockout of Klhl28 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Klhl28
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Klhl28 (kelch-like 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, cellular_component, cytoplasm
Pathways:
UniProt: Q9CR40
Entrez ID: 66689
|
Does Knockout of Atp6v1b2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Atp6v1b2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atp6v1b2 (ATPase, H+ transporting, lysosomal V1 subunit B2)
Type: protein-coding
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Located in several cellular components, including apical plasma membrane; microvillus; and ruffle. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study autosomal dominant congenital deafness with onychodystrophy and epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy. Orthologous to human ATP6V1B2 (ATPase H+ transporting V1 subunit B2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ATP metabolic process, monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification, vacuolar acidification; MF: ATP binding, nucleotide binding, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, extrinsic component of synaptic vesicle membrane, melanosome, membrane, microvillus, myelin sheath, plasma membrane, proton-transporting V-type ATPase, V1 domain, ruffle, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: P62814
Entrez ID: 11966
|
Does Knockout of Fscb in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Fscb
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fscb (fibrous sheath CABYR binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of protein sumoylation; MF: calcium ion binding, protein binding; CC: cell projection, cilium, motile cilium, sperm fibrous sheath, sperm principal piece
Pathways:
UniProt: E9QJV1
Entrez ID: 623046
|
Does Knockout of Pex12 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Pex12
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pex12 (peroxisomal biogenesis factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to reactive oxygen species, peroxisome organization, pexophagy, protein import into peroxisome matrix, protein import into peroxisome matrix, receptor recycling, protein import into peroxisome matrix, substrate release, protein monoubiquitination, protein polyubiquitination, protein transport, protein ubiquitination, protein unfolding; MF: metal ion binding, ubiquitin ligase activator activity, ubiquitin-protein transferase activity, zinc ion binding; CC: membrane, peroxisomal importomer complex, peroxisomal membrane, peroxisome
Pathways: Class I peroxisomal membrane protein import, E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Post-translational protein modification, Protein localization, Protein ubiquitination
UniProt: Q8VC48
Entrez ID: 103737
|
Does Knockout of Ino80 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ino80
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ino80 (INO80 complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA recombination, DNA repair, DNA-templated transcription, UV-damage excision repair, cell division, cellular response to UV, cellular response to ionizing radiation, chromatin remodeling, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, mitotic sister chromatid segregation, positive regulation of DNA metabolic process, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of cell growth, positive regulation of nuclear cell cycle DNA replication, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, spindle assembly, telomere maintenance; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent chromatin remodeler activity, DNA binding, actin binding, alpha-tubulin binding, histone binding, hydrolase activity, nucleotide binding; CC: Ino80 complex, chromosome, cytoplasm, cytoskeleton, cytosol, microtubule, nuclear body, nucleoplasm, nucleus, spindle
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q6ZPV2
Entrez ID: 68142
|
Does Knockout of Cic in Malignant Peripheral Nerve Sheath Tumor (MPNST) cancer cell causally result in tumorigenicity?
| 1
| 2,184
|
Knockout
|
Cic
|
tumorigenicity
|
Malignant Peripheral Nerve Sheath Tumor (MPNST) cancer cell
|
Gene: Cic (capicua transcriptional repressor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, learning, lung alveolus development, memory, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, social behavior; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, protein binding; CC: nucleoplasm, nucleus, protein-containing complex
Pathways: Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q924A2
Entrez ID: 71722
|
Does Knockout of Ddx24 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Ddx24
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ddx24 (DEAD box helicase 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: cytoplasm, nucleolus, nucleus
Pathways:
UniProt: Q9ESV0
Entrez ID: 27225
|
Does Knockout of Rora in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Rora
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Rora (RAR-related orphan receptor alpha)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: T-helper 17 cell differentiation, angiogenesis, cGMP metabolic process, cellular response to hypoxia, cellular response to interleukin-1, cellular response to sterol, cellular response to tumor necrosis factor, cerebellar Purkinje cell differentiation, cerebellar granule cell precursor proliferation, cholesterol homeostasis, circadian regulation of gene expression, circadian rhythm, intracellular receptor signaling pathway, muscle cell differentiation, negative regulation of canonical NF-kappaB signal transduction, negative regulation of fat cell differentiation, negative regulation of inflammatory response, nitric oxide biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of circadian rhythm, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial growth factor production, regulation of DNA-templated transcription, regulation of circadian rhythm, regulation of gene expression, regulation of glucose metabolic process, regulation of macrophage activation, regulation of smoothened signaling pathway, regulation of steroid metabolic process, regulation of transcription by RNA polymerase II, rhythmic process, triglyceride homeostasis, xenobiotic metabolic process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, beta-catenin binding, ligand-modulated transcription factor activity, metal ion binding, nuclear receptor activity, oxysterol binding, protein binding, sequence-specific DNA binding, transcription coactivator binding, transcription coregulator binding, transcription corepressor binding, zinc ion binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Circadian rhythm - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Inflammatory bowel disease - Mus musculus (mouse), Metabolism of proteins, Nuclear Receptor transcription pathway, Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of intracellular receptors, Spinocerebellar ataxia - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse)
UniProt: P51448
Entrez ID: 19883
|
Does Knockout of Nagpa in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Nagpa
|
cell cycle progression
|
breast epithelium
|
Gene: Nagpa (N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase)
Type: protein-coding
Summary: Predicted to enable N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity. Acts upstream of or within secretion of lysosomal enzymes. Predicted to be located in Golgi cisterna membrane. Is expressed in thymus primordium. Orthologous to human NAGPA (N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: protein glycosylation, secretion of lysosomal enzymes; MF: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity, hydrolase activity; CC: Golgi apparatus, Golgi cisterna membrane, membrane
Pathways: Lysosome - Mus musculus (mouse)
UniProt: Q8BJ48
Entrez ID: 27426
|
Does Knockout of Cpa5 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Cpa5
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Cpa5 (carboxypeptidase A5)
Type: protein-coding
Summary: This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is expressed in mouse testes where the encoded protein is localized to the germ cells. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: proteolysis; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8R4H4
Entrez ID: 74649
|
Does Knockout of Mtcl1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Mtcl1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mtcl1 (microtubule crosslinking factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, chromosome segregation, establishment or maintenance of epithelial cell apical/basal polarity, microtubule bundle formation, positive regulation of protein targeting to membrane, regulation of autophagy; MF: microtubule binding, protein binding, protein homodimerization activity; CC: apical plasma membrane, apicolateral plasma membrane, cytoplasm, cytoskeleton, extracellular space, kinetochore, lateral plasma membrane, membrane, microtubule bundle, midbody, plasma membrane, spindle microtubule, spindle pole
Pathways:
UniProt: Q3UHU5
Entrez ID: 68617
|
Does Knockout of Cyp2j13 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Cyp2j13
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cyp2j13 (cytochrome P450, family 2, subfamily j, polypeptide 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epoxygenase P450 pathway, icosanoid metabolic process, linoleic acid metabolic process, organic acid metabolic process, xenobiotic metabolic process; MF: arachidonate 11,12-epoxygenase activity, arachidonate 14,15-epoxygenase activity, arachidonate epoxygenase activity, heme binding, iron ion binding, isomerase activity, linoleic acid epoxygenase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse)
UniProt: B1AWM4, Q3UNV4, B1AWM5, F6R6R4
Entrez ID: 230459
|
Does Knockout of Dclk2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Dclk2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dclk2 (doublecortin-like kinase 2)
Type: protein-coding
Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: central nervous system neuron development, hippocampus development, intracellular signal transduction, microtubule cytoskeleton organization, negative regulation of protein localization to nucleus, protein localization to nucleus, pyramidal neuron development; MF: ATP binding, kinase activity, microtubule binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytoskeleton
Pathways:
UniProt: Q6PGN3
Entrez ID: 70762
|
Does Knockout of Foxred1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Foxred1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Foxred1 (FAD-dependent oxidoreductase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly; CC: cytoplasm, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q3TQB2
Entrez ID: 235169
|
Does Knockout of Pnn in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Pnn
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pnn (pinin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cell-cell adhesion, mRNA processing; CC: anchoring junction, catalytic step 2 spliceosome, cytoplasm, desmosome, exon-exon junction complex, nuclear speck, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: O35691
Entrez ID: 18949
|
Does Knockout of Dscc1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,158
|
Knockout
|
Dscc1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dscc1 (DNA replication and sister chromatid cohesion 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, maintenance of mitotic sister chromatid cohesion, mitotic sister chromatid cohesion, positive regulation of DNA-directed DNA polymerase activity, post-translational protein acetylation, regulation of DNA replication; MF: DNA binding, DNA clamp loader activity, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, chromatin, chromosome, centromeric region, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance
UniProt: Q14AI0
Entrez ID: 72107
|
Does Knockout of Ciz1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Ciz1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ciz1 (CDKN1A interacting zinc finger protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of protein location in nucleus, positive regulation of DNA-templated DNA replication initiation, random inactivation of X chromosome; MF: cyclin binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q3UUV0, Q8VEH2, A2AN61, Q3TXU6, F7AT58, F6XWQ4, F7BM53, F6S5B6, A0A0A0MQJ7, A0A0A6YVQ0, F7D5G9
Entrez ID: 68379
|
Does Knockout of Ndufaf1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Ndufaf1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ndufaf1 (NADH:ubiquinone oxidoreductase complex assembly factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chaperone-mediated protein complex assembly, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly; CC: cytosol, mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CWX2
Entrez ID: 69702
|
Does Knockout of 9030624G23Rik in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
9030624G23Rik
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: 9030624G23Rik (RIKEN cDNA 9030624G23 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of DNA-templated transcription; CC: cellular_component, nucleus
Pathways:
UniProt: Q9D308
Entrez ID: 66808
|
Does Knockout of Ppil2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Ppil2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ppil2 (peptidylprolyl isomerase (cyclophilin)-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, protein folding, protein localization to plasma membrane, protein polyubiquitination, protein ubiquitination; MF: peptidyl-prolyl cis-trans isomerase activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity; CC: catalytic step 2 spliceosome, cytoplasm, nucleoplasm, nucleus, plasma membrane, spliceosomal complex
Pathways: Basigin interactions, Cell surface interactions at the vascular wall, Hemostasis, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Ubiquitin mediated proteolysis - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9D787
Entrez ID: 66053
|
Does Knockout of Psenen in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Psenen
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Psenen (presenilin enhancer gamma secretase subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch receptor processing, Notch signaling pathway, amyloid precursor protein catabolic process, amyloid precursor protein metabolic process, amyloid-beta formation, membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, positive regulation of endopeptidase activity, protein processing; MF: endopeptidase activator activity, enzyme binding, protein binding; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, gamma-secretase complex, membrane, plasma membrane, presynaptic membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Axon guidance, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, NOTCH3 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Nervous system development, Noncanonical activation of NOTCH3, Notch signaling pathway - Mus musculus (mouse), Nuclear signaling by ERBB4, Regulated proteolysis of p75NTR, Signal Transduction, Signaling by ERBB4, Signaling by NOTCH, Signaling by NOTCH3, Signaling by Receptor Tyrosine Kinases, Signaling by TGFB family members, Signaling by TGFBR3, TGFBR3 PTM regulation, p75 NTR receptor-mediated signalling
UniProt: Q9CQR7
Entrez ID: 66340
|
Does Knockout of Numa1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Numa1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Numa1 (nuclear mitotic apparatus protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anastral spindle assembly, astral microtubule organization, cell division, chromosome segregation, establishment of mitotic spindle orientation, meiotic cell cycle, microtubule bundle formation, positive regulation of BMP signaling pathway, positive regulation of chromosome segregation, positive regulation of chromosome separation, positive regulation of hair follicle development, positive regulation of intracellular transport, positive regulation of keratinocyte differentiation, positive regulation of microtubule polymerization, positive regulation of mitotic spindle elongation, positive regulation of protein localization to cell cortex, positive regulation of protein localization to spindle pole body, positive regulation of spindle assembly, regulation of metaphase plate congression, regulation of mitotic spindle organization; MF: disordered domain specific binding, dynein complex binding, lipid binding, microtubule binding, microtubule minus-end binding, microtubule plus-end binding, phosphatidylinositol binding, protein binding, protein domain specific binding, protein-containing complex binding, tubulin binding; CC: cell cortex, cell cortex region, centrosome, chromosome, cortical microtubule, cytoplasm, cytoplasmic microtubule bundle, cytoskeleton, cytosol, dendrite, lateral cell cortex, lateral plasma membrane, membrane, microtubule, microtubule bundle, microtubule minus-end, microtubule plus-end, mitotic spindle, mitotic spindle astral microtubule, mitotic spindle midzone, mitotic spindle pole, neuronal cell body, nuclear matrix, nucleoplasm, nucleus, plasma membrane, protein-containing complex, spindle microtubule, spindle pole, spindle pole centrosome
Pathways: Cell Cycle, Cell Cycle, Mitotic, M Phase, Mitotic Prometaphase, Mitotic Prophase, Recruitment of NuMA to mitotic centrosomes
UniProt: E9Q7G0
Entrez ID: 101706
|
Does Knockout of Fads3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Fads3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fads3 (fatty acid desaturase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid metabolic process, gene expression, lipid metabolic process, sphingolipid metabolic process, unsaturated fatty acid biosynthetic process; MF: oxidoreductase activity, oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; CC: cellular_component, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: oleate biosynthesis II (animals)
UniProt: Q9JJE7
Entrez ID: 60527
|
Does Knockout of Sgtb in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Sgtb
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sgtb (small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: post-translational protein targeting to endoplasmic reticulum membrane, protein heterooligomerization, protein homooligomerization; MF: Hsp70 protein binding, identical protein binding, molecular adaptor activity, protein heterodimerization activity, protein homodimerization activity, protein-folding chaperone binding; CC: TRC complex, membrane
Pathways:
UniProt: Q8VD33
Entrez ID: 218544
|
Does Knockout of Mrps21 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,158
|
Knockout
|
Mrps21
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mrps21 (mitochondrial ribosomal protein S21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: P58059
Entrez ID: 66292
|
Does Knockout of Ankrd40 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ankrd40
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ankrd40 (ankyrin repeat domain 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5SUE8
Entrez ID: 71452
|
Does Knockout of Sbf1 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Sbf1
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Sbf1 (SET binding factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of cell growth, spermatid development, spermatogenesis; MF: guanyl-nucleotide exchange factor activity, phosphatase regulator activity, pseudophosphatase activity; CC: cell projection, cytoplasm, membrane, neuron projection, nuclear body, perinuclear region of cytoplasm
Pathways: Membrane Trafficking, Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Synthesis of PIPs at the ER membrane, Vesicle-mediated transport
UniProt: Q6ZPE2
Entrez ID: 77980
|
Does Knockout of Dlgap5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Dlgap5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dlgap5 (DLG associated protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centrosome localization, chromosome segregation, kinetochore assembly, mitotic spindle organization, regulation of mitotic cell cycle, signaling; CC: cytoplasm, cytoskeleton, cytosol, mitotic spindle, nucleus, spindle, spindle pole centrosome
Pathways:
UniProt: Q8K4R9
Entrez ID: 218977
|
Does Knockout of Sdhaf1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Sdhaf1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sdhaf1 (succinate dehydrogenase complex assembly factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex II assembly; CC: mitochondrial matrix, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism
UniProt: Q3U276
Entrez ID: 68332
|
Does Knockout of Uri1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Uri1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Uri1 (URI1, prefoldin-like chaperone)
Type: protein-coding
Summary: Predicted to enable several functions, including RNA polymerase II complex binding activity; phosphatase inhibitor activity; and transcription corepressor activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Is expressed in several structures, including alimentary system; brain; epithelium; genitourinary system; and muscle tissue. Orthologous to human URI1 (URI1 prefoldin like chaperone). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to growth factor stimulus, cellular response to steroid hormone stimulus, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of phosphatase activity, negative regulation of transcription by RNA polymerase II, regulation of cell growth, regulation of transcription by RNA polymerase II, response to virus; MF: RNA polymerase II complex binding, chromatin binding, phosphatase inhibitor activity, phosphoprotein binding, protein phosphatase inhibitor activity, transcription corepressor activity; CC: RPAP3/R2TP/prefoldin-like complex, cell projection, cytoplasm, cytosol, dendrite, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q3TLD5
Entrez ID: 19777
|
Does Knockout of Dhx29 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Dhx29
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Dhx29 (DExH-box helicase 29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: formation of translation preinitiation complex, positive regulation of translational initiation, ribosome assembly, translation, translational initiation; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, nucleic acid binding, nucleotide binding, ribonucleoside triphosphate phosphatase activity, ribosomal small subunit binding, translation activator activity, translation initiation factor activity; CC: cytoplasm, cytosolic small ribosomal subunit, eukaryotic 43S preinitiation complex, mitochondrion
Pathways:
UniProt: Q6PGC1
Entrez ID: 218629
|
Does Knockout of Ccl21b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Ccl21b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ccl21b (C-C motif chemokine ligand 21B (leucine))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CCL21-activated CCR7 signaling pathway, G protein-coupled receptor signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, cell chemotaxis, cellular response to prostaglandin E stimulus, chemokine-mediated signaling pathway, chemotaxis, dendritic cell chemotaxis, eosinophil chemotaxis, establishment of T cell polarity, immune response, inflammatory response, killing of cells of another organism, leukocyte chemotaxis, mesangial cell-matrix adhesion, negative regulation of dendritic cell apoptotic process, negative regulation of leukocyte tethering or rolling, negative regulation of myeloid cell differentiation, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of actin filament polymerization, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell adhesion mediated by integrin, positive regulation of cell migration, positive regulation of cell motility, positive regulation of cell-matrix adhesion, positive regulation of filopodium assembly, positive regulation of myeloid dendritic cell chemotaxis, positive regulation of neutrophil chemotaxis, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of phospholipase C/protein kinase C signal transduction, positive regulation of pseudopodium assembly, release of sequestered calcium ion into cytosol, ruffle organization; MF: CCR chemokine receptor binding, chemokine activity, chemokine receptor binding, cytokine activity; CC: external side of plasma membrane, extracellular region, extracellular space
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, NF-kappa B signaling pathway - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P86793, P86792
Entrez ID: 100042493
|
Does Knockout of Acsl6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Acsl6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Acsl6 (acyl-CoA synthetase long-chain family member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid metabolic process, fatty acid transport, lipid metabolic process, long-chain fatty acid metabolic process, long-chain fatty-acyl-CoA biosynthetic process, neuroblast proliferation, phospholipid biosynthetic process, positive regulation of long-chain fatty acid import across plasma membrane, positive regulation of neuron projection development, triglyceride biosynthetic process, very long-chain fatty acid metabolic process; MF: ATP binding, arachidonate-CoA ligase activity, enzyme binding, ligase activity, long-chain fatty acid-CoA ligase activity, nucleotide binding, protein binding, protein homodimerization activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion, peroxisomal membrane, peroxisome
Pathways: Adipocytokine signaling pathway - Mus musculus (mouse), Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Ferroptosis - Mus musculus (mouse), Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), Peroxisome - Mus musculus (mouse), Synthesis of very long-chain fatty acyl-CoAs, Thermogenesis - Mus musculus (mouse), fatty acid β-oxidation I, fatty acid β-oxidation II (core pathway), fatty acid activation
UniProt: Q91WC3
Entrez ID: 216739
|
Does Knockout of Prpf18 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Prpf18
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Prpf18 (pre-mRNA processing factor 18)
Type: protein-coding
Summary: Predicted to be involved in generation of catalytic spliceosome for second transesterification step and negative regulation of protein metabolic process. Predicted to be located in nuclear speck. Predicted to be part of U2-type post-spliceosomal complex; U4/U6 x U5 tri-snRNP complex; and U5 snRNP. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; genitourinary system; and sensory organ. Orthologous to human PRPF18 (pre-mRNA processing factor 18). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, generation of catalytic spliceosome for second transesterification step, mRNA processing, negative regulation of protein metabolic process; CC: U2-type post-spliceosomal complex, U4/U6 x U5 tri-snRNP complex, U5 snRNP, nuclear speck, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8BM39
Entrez ID: 67229
|
Does Knockout of Emilin1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Emilin1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Emilin1 (elastin microfibril interfacer 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aortic valve morphogenesis, cell adhesion, cell adhesion mediated by integrin, cell migration, cell-matrix adhesion, elastic fiber assembly, extracellular matrix organization, negative regulation of ERK1 and ERK2 cascade, negative regulation of SMAD protein signal transduction, negative regulation of angiogenesis, negative regulation of cell activation, negative regulation of cell migration, negative regulation of collagen biosynthetic process, negative regulation of collagen fibril organization, negative regulation of gene expression, negative regulation of macrophage migration, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of vascular endothelial growth factor signaling pathway, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of blood coagulation, positive regulation of cell-substrate adhesion, positive regulation of defense response to bacterium, positive regulation of extracellular matrix assembly, positive regulation of gene expression, positive regulation of platelet aggregation, regulation of blood pressure, regulation of cell population proliferation; MF: extracellular matrix constituent conferring elasticity, identical protein binding, integrin binding involved in cell-matrix adhesion, molecular adaptor activity, protein binding; CC: EMILIN complex, collagen trimer, extracellular matrix, extracellular region, extracellular space, integrin alpha4-beta1 complex
Pathways: Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres
UniProt: Q99K41
Entrez ID: 100952
|
Does Knockout of Rbpms in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Rbpms
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Rbpms (RNA binding protein gene with multiple splicing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SMAD protein signal transduction, positive regulation of DNA-templated transcription, protein-containing complex assembly, regulation of alternative mRNA splicing, via spliceosome, response to oxidative stress; MF: RNA binding, identical protein binding, mRNA 3'-UTR binding, mRNA CDS binding, mRNA binding, molecular adaptor activity, nucleic acid binding, pre-mRNA binding, pre-mRNA intronic binding, protein homodimerization activity, transcription coactivator activity; CC: P-body, cytoplasm, cytoplasmic stress granule, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9WVB0
Entrez ID: 19663
|
Does Knockout of Tomm6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Tomm6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tomm6 (translocase of outer mitochondrial membrane 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion
Pathways: Autophagy, Macroautophagy, Mitophagy, PINK1-PRKN Mediated Mitophagy, Selective autophagy
UniProt: Q9CQN3
Entrez ID: 66119
|
Does Knockout of Dhx33 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Dhx33
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Dhx33 (DEAH-box helicase 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of MAPK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of transcription by RNA polymerase I, positive regulation of type I interferon production, translational initiation; MF: ATP binding, ATP hydrolysis activity, DNA-binding transcription factor binding, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding, rDNA binding, ribosomal large subunit binding; CC: NLRP3 inflammasome complex, canonical inflammasome complex, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q80VY9
Entrez ID: 216877
|
Does Knockout of Sdk2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Sdk2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Sdk2 (sidekick cell adhesion molecule 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye photoreceptor cell differentiation, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, retina layer formation, synapse assembly; CC: membrane, plasma membrane, synapse
Pathways: Cell junction organization, Cell-Cell communication, Cell-cell junction organization, SDK interactions
UniProt: Q6V4S5
Entrez ID: 237979
|
Does Knockout of Nhej1 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,558
|
Knockout
|
Nhej1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Nhej1 (non-homologous end joining factor 1)
Type: protein-coding
Summary: Predicted to enable DNA end binding activity and DNA polymerase binding activity. Involved in double-strand break repair via nonhomologous end joining. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Predicted to be active in site of double-strand break. Human ortholog(s) of this gene implicated in severe combined immunodeficiency 124. Orthologous to human NHEJ1 (non-homologous end joining factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell differentiation, DNA damage response, DNA repair, T cell differentiation, double-strand break repair, double-strand break repair via nonhomologous end joining, immunoglobulin V(D)J recombination, response to ionizing radiation, telomere maintenance; MF: DNA binding, DNA end binding, DNA polymerase binding, protein binding; CC: DNA ligase IV complex, DNA-dependent protein kinase-DNA ligase 4 complex, chromosome, fibrillar center, nonhomologous end joining complex, nucleoplasm, nucleus, site of double-strand break
Pathways: DNA Double-Strand Break Repair, DNA Repair, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ)
UniProt: Q3KNJ2
Entrez ID: 75570
|
Does Knockout of Sbds in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Sbds
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sbds (SBDS ribosome maturation factor)
Type: protein-coding
Summary: This gene encodes a protein that is necessary for ribosome function and maintaining normal levels of protein synthesis. The encoded protein may function to activate ribosomes for translation, and may be involved in cellular response to stress and DNA damage. Loss of this gene is embryonic lethal while deficiency of the encoded protein in the pancreas is associated with symptoms of Shwachman-Diamond syndrome. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: bone marrow development, bone mineralization, cytosolic ribosome assembly, hematopoietic progenitor cell differentiation, inner cell mass cell proliferation, leukocyte chemotaxis, mitotic spindle organization, rRNA processing, ribosome biogenesis; MF: microtubule binding, rRNA binding, ribosome binding; CC: cytoplasm, cytoskeleton, cytosol, nucleolus, nucleoplasm, nucleus, spindle, spindle pole
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: P70122
Entrez ID: 66711
|
Does Knockout of Pepd in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Pepd
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pepd (peptidase D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CARD8 inflammasome complex assembly, collagen catabolic process, negative regulation of programmed cell death, proteolysis; MF: dipeptidase activity, hydrolase activity, manganese ion binding, metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptidase activity, proline dipeptidase activity
Pathways:
UniProt: Q11136
Entrez ID: 18624
|
Does Knockout of Trim71 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Trim71
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Trim71 (tripartite motif-containing 71)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, G1/S transition of mitotic cell cycle, fibroblast growth factor receptor signaling pathway, miRNA processing, miRNA-mediated gene silencing by inhibition of translation, negative regulation of translation, neural tube closure, neural tube development, positive regulation of miRNA-mediated gene silencing, post-transcriptional regulation of gene expression, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of miRNA-mediated gene silencing, regulation of neural precursor cell proliferation, regulation of protein metabolic process, regulatory ncRNA-mediated gene silencing, stem cell proliferation; MF: RNA binding, metal ion binding, miRNA binding, protein binding, transferase activity, translation repressor activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: P-body, cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, MicroRNAs in cancer - Mus musculus (mouse)
UniProt: Q1PSW8
Entrez ID: 636931
|
Does Knockout of Ppp2r3a in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Ppp2r3a
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ppp2r3a (protein phosphatase 2, regulatory subunit B'', alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: eye photoreceptor cell differentiation, negative regulation of canonical Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of protein catabolic process, regulation of canonical Wnt signaling pathway, regulation of cell migration involved in somitogenic axis elongation, somatic muscle development, somitogenesis; MF: calcium ion binding, metal ion binding, protein phosphatase regulator activity, protein-macromolecule adaptor activity; CC: protein phosphatase type 2A complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q3V1Y6, B2RXC8, G3X9E8, Q8BXX8
Entrez ID: 235542
|
Does Knockout of Zp2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Zp2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zp2 (zona pellucida glycoprotein 2)
Type: protein-coding
Summary: This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: binding of sperm to zona pellucida, prevention of polyspermy, single fertilization; MF: acrosin binding, identical protein binding, protein binding, structural constituent of egg coat; CC: egg coat, endoplasmic reticulum, extracellular matrix, extracellular region, membrane, multivesicular body, plasma membrane
Pathways: Fertilization, Interaction With Cumulus Cells And The Zona Pellucida, Reproduction
UniProt: P20239
Entrez ID: 22787
|
Does Knockout of Fancb in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,545
|
Knockout
|
Fancb
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Fancb (Fanconi anemia, complementation group B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, bone marrow development, cellular response to camptothecin, cellular response to xenobiotic stimulus, gene expression, hematopoietic stem cell differentiation, interstrand cross-link repair, negative regulation of double-strand break repair via homologous recombination, positive regulation of double-strand break repair via homologous recombination, replication-born double-strand break repair via sister chromatid exchange, response to stress, response to xenobiotic stimulus; CC: Fanconi anaemia nuclear complex, chromatin, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: Q5XJY6
Entrez ID: 237211
|
Does Knockout of Dusp16 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Dusp16
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dusp16 (dual specificity phosphatase 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of MAPK cascade, signal transduction; MF: JUN kinase binding, MAP kinase tyrosine phosphatase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, hydrolase activity, mitogen-activated protein kinase binding, mitogen-activated protein kinase p38 binding, phosphatase activity, phosphoprotein phosphatase activity, protein carrier chaperone, protein serine/threonine phosphatase activity, protein tyrosine/threonine phosphatase activity; CC: cytoplasm, nucleoplasm, nucleus
Pathways: MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Negative regulation of MAPK pathway, RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, Signal Transduction
UniProt: F6UIK0, Q6PCP3, Q8BZE4, A0A0N4SV20, A0A0N4SUV2
Entrez ID: 70686
|
Does Knockout of Mbp in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Mbp
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mbp (myelin basic protein)
Type: protein-coding
Summary: The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called 'Golli-Mbp') that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, maintenance of blood-brain barrier, membrane organization, myelination, negative regulation of axonogenesis, negative regulation of heterotypic cell-cell adhesion, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of interleukin-6 production, response to progesterone, response to toxic substance, sensory perception of sound; MF: calmodulin binding, lipid binding, protease binding, structural constituent of myelin sheath; CC: cell periphery, cell projection, cell surface, compact myelin, cytoplasm, internode region of axon, membrane, myelin sheath, neuronal cell body, nucleus, plasma membrane, protein-containing complex
Pathways:
UniProt: P04370
Entrez ID: 17196
|
Does Knockout of Gtf2f2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gtf2f2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gtf2f2 (general transcription factor IIF, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity; CC: RNA polymerase II transcription regulator complex, RNA polymerase II, holoenzyme, microtubule cytoskeleton, nucleoplasm, nucleus, transcription factor TFIIF complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Mus musculus (mouse), ESR-mediated signaling, Estrogen-dependent gene expression, FGFR2 alternative splicing, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q8R0A0
Entrez ID: 68705
|
Does Knockout of Sp110 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Sp110
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sp110 (Sp110 nuclear body protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, immune system process, innate immune response, positive regulation of apoptotic process, regulation of transcription by RNA polymerase II, response to bacterium; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q8BVK9
Entrez ID: 109032
|
Does Knockout of Ccnt1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Ccnt1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Ccnt1 (cyclin T1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, host-mediated activation of viral transcription, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of transcription by RNA polymerase II, response to xenobiotic stimulus; MF: 7SK snRNA binding, DNA binding, DNA-binding transcription factor binding, RNA polymerase binding, chromatin binding, cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase regulator activity, molecular condensate scaffold activity, protein binding, protein kinase binding, snRNA binding, transcription cis-regulatory region binding; CC: P-TEFb complex, cyclin/CDK positive transcription elongation factor complex, cytosol, nucleoplasm, nucleus
Pathways: ESR-mediated signaling, Estrogen-dependent gene expression, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA polymerase II transcribes snRNA genes, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by Nuclear Receptors, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q9QWV9
Entrez ID: 12455
|
Does Knockout of Naa25 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Naa25
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Naa25 (N(alpha)-acetyltransferase 25, NatB auxiliary subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, NatB complex, cytoplasm, cytosol
Pathways:
UniProt: Q8BWZ3
Entrez ID: 231713
|
Does Knockout of Mre11a in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,525
|
Knockout
|
Mre11a
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Mre11a (MRE11A homolog A, double strand break repair nuclease)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA repair, DNA strand resection involved in replication fork processing, R-loop processing, cell population proliferation, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, homologous chromosome pairing at meiosis, homologous recombination, host-mediated suppression of symbiont invasion, meiotic DNA double-strand break formation, meiotic cell cycle, mitochondrial double-strand break repair via homologous recombination, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, mitotic intra-S DNA damage checkpoint signaling, negative regulation of apoptotic process, negative regulation of double-strand break repair via nonhomologous end joining, positive regulation of double-strand break repair, positive regulation of telomere maintenance, sister chromatid cohesion, telomere maintenance, telomeric 3' overhang formation; MF: 3'-5' exonuclease activity, 3'-5'-DNA exonuclease activity, DNA binding, DNA endonuclease activity, DNA helicase activity, endonuclease activity, exonuclease activity, hydrolase activity, identical protein binding, manganese ion binding, metal ion binding, nuclease activity, protein binding, single-stranded DNA endodeoxyribonuclease activity; CC: BRCA1-C complex, Mre11 complex, PML body, chromatin, chromosomal region, chromosome, chromosome, telomeric region, condensed nuclear chromosome, cytoplasm, nucleoplasm, nucleus, perinuclear region of cytoplasm, replication fork, site of double-strand break
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Cytosolic sensors of pathogen-associated DNA , DNA Damage/Telomere Stress Induced Senescence, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through MMEJ (alt-NHEJ), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Immune System, Innate Immune System, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Sensing of DNA Double Strand Breaks, Transcriptional Regulation by TP53
UniProt: Q61216
Entrez ID: 17535
|
Does Knockout of Gm1647 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Gm1647
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Gm1647 (predicted gene 1647)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 381452
|
Does Knockout of Mtrf1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Mtrf1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mtrf1 (mitochondrial translational release factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translational termination, translation, translational termination; MF: translation release factor activity, translation release factor activity, codon specific; CC: cytoplasm, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial translation, Mitochondrial translation termination, Translation
UniProt: Q8K126
Entrez ID: 211253
|
Does Knockout of Ndfip1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,543
|
Knockout
|
Ndfip1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Ndfip1 (Nedd4 family interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular iron ion homeostasis, metal ion transport, negative regulation of CD4-positive, alpha-beta T cell proliferation, negative regulation of gene expression, negative regulation of inflammatory response, negative regulation of interleukin-4 production, negative regulation of isotype switching to IgE isotypes, negative regulation of protein transport, negative regulation of type 2 immune response, positive regulation of protein catabolic process, positive regulation of protein ubiquitination, regulation of isotype switching to IgG isotypes, regulation of lymphocyte differentiation, regulation of myeloid leukocyte differentiation, ubiquitin-dependent protein catabolic process, vacuolar transport; MF: WW domain binding, protein binding; CC: Golgi apparatus, Golgi membrane, cell cortex, cell projection, cytoplasm, dendrite, endoplasmic reticulum, endosome, endosome membrane, extracellular region, membrane, neuron projection, perinuclear region of cytoplasm, synapse
Pathways:
UniProt: Q8R0W6
Entrez ID: 65113
|
Does Knockout of Spns3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Spns3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Spns3 (SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid transport, transmembrane transport; MF: transmembrane transporter activity; CC: membrane
Pathways:
UniProt: Q9D232
Entrez ID: 77577
|
Does Knockout of Mrpl11 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Mrpl11
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mrpl11 (mitochondrial ribosomal protein L11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: large ribosomal subunit rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CQF0
Entrez ID: 66419
|
Does Knockout of Nsmce3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Nsmce3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nsmce3 (NSE3 homolog, SMC5-SMC6 complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cellular response to UV, cellular response to hydroxyurea, cellular response to radiation, negative regulation of transcription by RNA polymerase II, positive regulation of protein ubiquitination, regulation of DNA-templated transcription, regulation of macromolecule metabolic process, regulation of primary metabolic process; MF: protein binding, protein dimerization activity; CC: Smc5-Smc6 complex, chromosome, chromosome, telomeric region, cytoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q9CPR8
Entrez ID: 66647
|
Does Knockout of Atg3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Atg3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Atg3 (autophagy related 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, autophagy of mitochondrion, glycophagy, macroautophagy, mitochondrial fragmentation involved in apoptotic process, negative regulation of phagocytosis, nucleophagy, protein transport, protein ubiquitination, regulation of cilium assembly; MF: Atg12 transferase activity, Atg8-family conjugating enzyme activity, Atg8-family ligase activity, enzyme binding, protein binding, transferase activity, ubiquitin-like protein transferase activity; CC: Atg12-Atg5-Atg16 complex, cytoplasm, cytoplasmic ubiquitin ligase complex, cytosol, phagophore assembly site
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Macroautophagy
UniProt: Q9CPX6
Entrez ID: 67841
|
Does Knockout of Pitpnm1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Pitpnm1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Pitpnm1 (phosphatidylinositol transfer protein, membrane-associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermembrane lipid transfer, phospholipid transport, protein transport; MF: calcium ion binding, metal ion binding, phosphatidic acid binding, phosphatidylcholine binding, phosphatidylcholine transporter activity, phosphatidylinositol binding, phosphatidylinositol transfer activity, phospholipid binding, phospholipid transporter activity, receptor tyrosine kinase binding; CC: Golgi apparatus, Golgi cisterna membrane, cell body, cleavage furrow, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane, midbody
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PI
UniProt: O35954
Entrez ID: 18739
|
Does Knockout of Slc25a3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Slc25a3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Slc25a3 (solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial phosphate ion transmembrane transport, phosphate ion transmembrane transport, proton transmembrane transport; MF: phosphate transmembrane transporter activity, phosphate:proton symporter activity, protein-containing complex binding, symporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion, myelin sheath
Pathways:
UniProt: Q8VEM8
Entrez ID: 18674
|
Does Knockout of Champ1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Champ1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Champ1 (chromosome alignment maintaining phosphoprotein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, protein localization to kinetochore, protein localization to microtubule, sister chromatid biorientation; MF: metal ion binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, cytoplasm, cytoskeleton, kinetochore, nuclear body, nucleoplasm, nucleus, spindle
Pathways:
UniProt: Q8K327
Entrez ID: 101994
|
Does Knockout of Nup188 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Nup188
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nup188 (nucleoporin 188)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein import into nucleus, protein transport; MF: structural constituent of nuclear pore; CC: nuclear envelope, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q6ZQH8
Entrez ID: 227699
|
Does Knockout of Cnksr1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Cnksr1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cnksr1 (connector enhancer of kinase suppressor of Ras 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, Rho protein signal transduction; MF: protein-macromolecule adaptor activity; CC: cell cortex
Pathways: MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Signal Transduction
UniProt: A2A9K7
Entrez ID: 194231
|
Does Knockout of Defa22 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Defa22
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Defa22 (defensin, alpha, 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, disruption of plasma membrane integrity in another organism, innate immune response; MF: pore-forming activity, protein homodimerization activity; CC: azurophil granule, extracellular region, extracellular space, midbody, secretory granule
Pathways: Alpha-defensins, Antimicrobial peptides, Defensins, Immune System, Innate Immune System, NOD-like receptor signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Staphylococcus aureus infection - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q8C1N8
Entrez ID: 382059
|
Does Knockout of Cxxc5 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Cxxc5
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cxxc5 (CXXC finger 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of generation of precursor metabolites and energy; MF: DNA binding, DNA-binding transcription factor binding, metal ion binding, methyl-CpG binding, sequence-specific DNA binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q91WA4
Entrez ID: 67393
|
Does Knockout of Dact3 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Dact3
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Dact3 (dishevelled-binding antagonist of beta-catenin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, negative regulation of epithelial to mesenchymal transition; MF: delta-catenin binding, identical protein binding, protein binding, protein kinase A binding, protein kinase C binding; CC: cytoplasm
Pathways:
UniProt: Q0PHV7
Entrez ID: 629378
|
Does Knockout of Tube1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Tube1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tube1 (tubulin, epsilon 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: centrosome, cytoplasm, cytoskeleton, microtubule
Pathways:
UniProt: Q9D6T1
Entrez ID: 71924
|
Does Knockout of Dcdc2c in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Dcdc2c
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dcdc2c (doublecortin domain containing 2C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, intracellular signal transduction; CC: cell projection, cilium, cytoplasm, microtubule, microtubule organizing center, motile cilium, sperm flagellum
Pathways:
UniProt: Q9D1B8
Entrez ID: 68511
|
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