prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Tcp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Tcp1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tcp1 (t-complex protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of establishment of protein localization to telomere, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, scaRNA localization to Cajal body; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, ubiquitin protein ligase binding, unfolded protein binding; CC: Golgi apparatus, acrosomal vesicle, cell body, centrosome, chaperonin-containing T-complex, cytoplasm, cytoskeleton, cytosol, heterochromatin, microtubule, microtubule organizing center, myelin sheath, pericentriolar material, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: P11983
Entrez ID: 21454
|
Does Knockout of Rif1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Rif1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rif1 (replication timing regulatory factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to leukemia inhibitory factor, negative regulation of double-strand break repair via homologous recombination, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of isotype switching, somatic stem cell population maintenance, subtelomeric heterochromatin formation, telomere maintenance, telomere maintenance in response to DNA damage; CC: chromatin, chromosome, chromosome, telomeric region, chromosome, telomeric repeat region, condensed chromosome, cytoplasm, cytoskeleton, female pronucleus, male pronucleus, nuclear membrane, nucleoplasm, nucleus, plasma membrane, site of double-strand break, spindle, spindle midzone
Pathways: DNA Double-Strand Break Repair, DNA Repair, Nonhomologous End-Joining (NHEJ), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: Q6PR54
Entrez ID: 51869
|
Does Knockout of Tnfrsf25 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Tnfrsf25
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Tnfrsf25 (tumor necrosis factor receptor superfamily, member 25)
Type: protein-coding
Summary: Predicted to be active in plasma membrane. Orthologous to human TNFRSF25 (TNF receptor superfamily member 25). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, negative regulation of multicellular organismal process, signal transduction; CC: membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, TNFR2 non-canonical NF-kB pathway, TNFs bind their physiological receptors
UniProt: B1AWN9, Q8VD70
Entrez ID: 85030
|
Does Knockout of Zfp90 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Zfp90
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zfp90 (zinc finger protein 90)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA binding, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q61967
Entrez ID: 22751
|
Does Knockout of Ier5l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ier5l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ier5l (immediate early response 5-like)
Type: protein-coding
Summary: Is expressed in several structures, including alimentary system; brain ventricular layer; hindlimb phalanx; salivary gland primordium; and sensory organ. Orthologous to human IER5L (immediate early response 5 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q99J55
Entrez ID: 72500
|
Does Knockout of Zfp68 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Zfp68
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp68 (zinc finger protein 68)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q9Z116, Q8BLK6, D3Z6N7
Entrez ID: 24135
|
Does Knockout of Snu13 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Snu13
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Snu13 (SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, box C/D snoRNP assembly, mRNA processing, mRNA splicing, via spliceosome, maturation of SSU-rRNA, ribosomal small subunit biogenesis, ribosome biogenesis, single fertilization; MF: ATPase binding, RNA binding, U3 snoRNA binding, U4 snRNA binding, U4atac snRNA binding, box C/D sno(s)RNA binding, snoRNA binding; CC: U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U4atac snRNP, box C/D methylation guide snoRNP complex, dense fibrillar component, nucleolus, nucleus, plasma membrane, precatalytic spliceosome, protein-containing complex, ribonucleoprotein complex, small-subunit processome, spliceosomal complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D0T1
Entrez ID: 20826
|
Does Knockout of Psma7 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Psma7
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Psma7 (proteasome subunit alpha 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: identical protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9Z2U0
Entrez ID: 26444
|
Does Knockout of Fam117a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Fam117a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fam117a (family with sequence similarity 117, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q7TNF9
Entrez ID: 215512
|
Does Knockout of Acsm2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Acsm2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Acsm2 (acyl-CoA synthetase medium-chain family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acyl-CoA metabolic process, fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process; MF: ATP binding, benzoate-CoA ligase activity, decanoate-CoA ligase activity, fatty acid ligase activity, fatty-acyl-CoA synthase activity, ligase activity, medium-chain fatty acid-CoA ligase activity, metal ion binding, nucleotide binding; CC: mitochondrial matrix, mitochondrion
Pathways: Amino Acid conjugation, Aspirin ADME, Biological oxidations, Butanoate metabolism - Mus musculus (mouse), Conjugation of benzoate with glycine, Conjugation of carboxylic acids, Conjugation of phenylacetate with glutamine, Conjugation of salicylate with glycine, Drug ADME, Metabolism, Phase II - Conjugation of compounds
UniProt: Q8K0L3
Entrez ID: 233799
|
Does Knockout of Trappc9 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Trappc9
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trappc9 (trafficking protein particle complex 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cerebral cortex development, endoplasmic reticulum to Golgi vesicle-mediated transport, neuron differentiation, vesicle coating, vesicle tethering; CC: TRAPP complex, TRAPPII protein complex, cytoplasm, endoplasmic reticulum, trans-Golgi network
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q3U0M1
Entrez ID: 76510
|
Does Knockout of Cd209b in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Cd209b
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Cd209b (CD209b antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detection of bacterium, detection of yeast, endocytosis, immune response, phagocytosis, recognition, positive regulation of phagocytosis, positive regulation of tumor necrosis factor production; MF: (1->3)-beta-D-glucan binding, D-mannose binding, calcium-dependent protein binding, carbohydrate binding, metal ion binding, pattern recognition receptor activity, polysaccharide binding, virus receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q8CJ91
Entrez ID: 69165
|
Does Knockout of Slc30a2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Slc30a2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Slc30a2 (solute carrier family 30 (zinc transporter), member 2)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and zinc:proton antiporter activity. Involved in zinc ion import into mitochondrion. Located in mitochondrial inner membrane and zymogen granule membrane. Is expressed in adrenal gland; embryo; and lung. Orthologous to human SLC30A2 (solute carrier family 30 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: intracellular zinc ion homeostasis, monoatomic cation transport, monoatomic ion transport, response to zinc ion, transmembrane transport, zinc export across plasma membrane, zinc ion import into lysosome, zinc ion import into mitochondrion, zinc ion import into organelle, zinc ion import into secretory vesicle, zinc ion import into zymogen granule, zinc ion transmembrane transport, zinc ion transport; MF: antiporter activity, identical protein binding, metal ion binding, monoatomic cation transmembrane transporter activity, protein binding, zinc ion transmembrane transporter activity, zinc:proton antiporter activity; CC: cytoplasm, cytoplasmic vesicle, endosome, endosome membrane, late endosome, lysosomal membrane, lysosome, membrane, mitochondrial inner membrane, mitochondrion, plasma membrane, secretory vesicle, transport vesicle membrane, zymogen granule membrane
Pathways:
UniProt: Q2HJ10
Entrez ID: 230810
|
Does Knockout of Mga in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 2,403
|
Knockout
|
Mga
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mga (MAX gene associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell fate specification, cellular response to leukemia inhibitory factor, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein dimerization activity; CC: MLL1 complex, chromatin, nucleus, protein-containing complex, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Transcriptional Regulation by E2F6
UniProt: A2AWL7
Entrez ID: 29808
|
Does Knockout of Nudcd3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Nudcd3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nudcd3 (NudC domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, protein folding, protein localization to pericentriolar material; CC: cytoplasm, cytoplasmic dynein complex
Pathways:
UniProt: Q8R1N4
Entrez ID: 209586
|
Does Knockout of Pelo in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Pelo
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Pelo (pelota mRNA surveillance and ribosome rescue factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA surveillance, cell division, chromosome organization, endoderm development, inner cell mass cell proliferation, mesenchymal to epithelial transition, nonfunctional rRNA decay, nuclear-transcribed mRNA catabolic process, no-go decay, nuclear-transcribed mRNA catabolic process, non-stop decay, positive regulation of BMP signaling pathway, regulation of translation, rescue of stalled ribosome, ribosome disassembly, stem cell population maintenance; MF: metal ion binding, nucleoside-triphosphatase regulator activity, protein binding, ribosome binding, stalled ribosome sensor activity; CC: Dom34-Hbs1 complex, cytoplasm, cytosolic ribosome
Pathways: Metabolism of proteins, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome-associated quality control, Translation, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q80X73
Entrez ID: 105083
|
Does Knockout of Morn2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Morn2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Morn2 (MORN repeat containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell differentiation, spermatogenesis; CC: acrosomal vesicle, cellular_component, cytoplasmic vesicle, nucleus
Pathways:
UniProt: Q6UL01
Entrez ID: 378462
|
Does Knockout of Krtap8-1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Krtap8-1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Krtap8-1 (keratin associated protein 8-1)
Type: protein-coding
Summary: Predicted to be located in cytosol and intermediate filament. Orthologous to human KRTAP8-1 (keratin associated protein 8-1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: O08633
Entrez ID: 16703
|
Does Knockout of Lrrc25 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Lrrc25
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Lrrc25 (leucine rich repeat containing 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, canonical NF-kappaB signal transduction, connective tissue replacement involved in inflammatory response wound healing, gene expression, heart development, inflammatory response, response to angiotensin, response to hydrostatic pressure, response to transforming growth factor beta; CC: cytoplasm, cytosol, endoplasmic reticulum, membrane, microtubule cytoskeleton
Pathways:
UniProt: Q8K1T1
Entrez ID: 211228
|
Does Knockout of Atp6v1g1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Atp6v1g1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Atp6v1g1 (ATPase, H+ transporting, lysosomal V1 subunit G1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to increased oxygen levels, intracellular iron ion homeostasis, monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: ATP hydrolysis activity, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: ATPase complex, apical plasma membrane, cytosol, extrinsic component of synaptic vesicle membrane, lysosomal membrane, membrane, plasma membrane, presynapse, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9CR51
Entrez ID: 66290
|
Does Knockout of BC005624 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
BC005624
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: BC005624 (cDNA sequence BC005624)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, chromosome segregation, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, regulation of homologous chromosome segregation; MF: RNA binding, U5 snRNA binding, molecular_function; CC: chromosome, chromosome, centromeric region, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q3TQI7
Entrez ID: 227707
|
Does Knockout of Polg2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Polg2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Polg2 (polymerase (DNA directed), gamma 2, accessory subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA repair, DNA replication, DNA-templated DNA replication, in utero embryonic development, mitochondrial DNA metabolic process, mitochondrial DNA replication, mitochondrion organization; MF: DNA binding, DNA polymerase binding, DNA polymerase processivity factor activity, DNA-directed DNA polymerase activity, double-stranded DNA binding, identical protein binding; CC: cytoplasm, gamma DNA polymerase complex, mitochondrial matrix, mitochondrial nucleoid, mitochondrion
Pathways: DNA Replication, Strand-asynchronous mitochondrial DNA replication
UniProt: Q9QZM2
Entrez ID: 50776
|
Does Knockout of 6430550D23Rik in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
6430550D23Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 6430550D23Rik (RIKEN cDNA 6430550D23 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ganglioside biosynthetic process via lactosylceramide, protein glycosylation, sialylation; MF: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity, sialyltransferase activity; CC: membrane
Pathways:
UniProt: B7ZCN5, A3KGJ9, B7ZCN8, B7ZCN7, D6RHS0, A3KGK0
Entrez ID: 320095
|
Does Knockout of Tmem82 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Tmem82
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmem82 (transmembrane protein 82)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8R115
Entrez ID: 213989
|
Does Knockout of Dimt1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Dimt1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dimt1 (DIM1 rRNA methyltransferase and ribosome maturation factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, positive regulation of rRNA processing, rRNA methylation, rRNA modification, rRNA processing, ribosomal small subunit biogenesis; MF: 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity, RNA binding, methyltransferase activity, rRNA (adenine-N6,N6-)-dimethyltransferase activity, transferase activity; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways:
UniProt: Q9D0D4
Entrez ID: 66254
|
Does Knockout of Slc6a8 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Slc6a8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc6a8 (solute carrier family 6 (neurotransmitter transporter, creatine), member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, creatine transmembrane transport, gamma-aminobutyric acid transport, monoatomic ion transport, neurotransmitter transport, protein catabolic process, sodium ion transmembrane transport, sodium ion transport; MF: choline transmembrane transporter activity, creatine transmembrane transporter activity, creatine:sodium symporter activity, gamma-aminobutyric acid:sodium:chloride symporter activity, symporter activity; CC: apical plasma membrane, glutamatergic synapse, membrane, plasma membrane, postsynaptic membrane, synapse
Pathways: Creatine metabolism, Metabolism, Metabolism of amino acids and derivatives
UniProt: Q8VBW1
Entrez ID: 102857
|
Does Knockout of Gnl1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Gnl1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gnl1 (guanine nucleotide binding protein-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response; MF: GTP binding, GTPase activity, nucleotide binding
Pathways:
UniProt: P36916
Entrez ID: 14670
|
Does Knockout of Ttc39a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Ttc39a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ttc39a (tetratricopeptide repeat domain 39A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome
Pathways:
UniProt: A2ACP1
Entrez ID: 230603
|
Does Knockout of Snu13 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Snu13
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Snu13 (SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, box C/D snoRNP assembly, mRNA processing, mRNA splicing, via spliceosome, maturation of SSU-rRNA, ribosomal small subunit biogenesis, ribosome biogenesis, single fertilization; MF: ATPase binding, RNA binding, U3 snoRNA binding, U4 snRNA binding, U4atac snRNA binding, box C/D sno(s)RNA binding, snoRNA binding; CC: U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U4atac snRNP, box C/D methylation guide snoRNP complex, dense fibrillar component, nucleolus, nucleus, plasma membrane, precatalytic spliceosome, protein-containing complex, ribonucleoprotein complex, small-subunit processome, spliceosomal complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D0T1
Entrez ID: 20826
|
Does Knockout of Oser1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Oser1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Oser1 (oxidative stress responsive serine rich 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hydrogen peroxide; CC: cellular_component, nucleus
Pathways:
UniProt: Q9D722
Entrez ID: 66680
|
Does Knockout of Atp7a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Atp7a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atp7a (ATPase, copper transporting, alpha polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, L-tryptophan metabolic process, T-helper cell differentiation, blood vessel development, blood vessel remodeling, cartilage development, catecholamine metabolic process, cellular response to amino acid stimulus, cellular response to copper ion, cellular response to platelet-derived growth factor stimulus, central nervous system neuron development, cerebellar Purkinje cell differentiation, collagen fibril organization, copper ion export, copper ion import, copper ion transport, dendrite morphogenesis, detoxification of copper ion, dopamine metabolic process, elastic fiber assembly, epinephrine metabolic process, establishment of localization in cell, extracellular matrix organization, glycoprotein biosynthetic process, hair follicle morphogenesis, intracellular copper ion homeostasis, locomotory behavior, lung alveolus development, mitochondrion organization, monoatomic cation transport, monoatomic ion transport, negative regulation of catecholamine metabolic process, negative regulation of iron ion transmembrane transport, negative regulation of neuron apoptotic process, neuron cellular homeostasis, neuron projection morphogenesis, norepinephrine biosynthetic process, norepinephrine metabolic process, pigmentation, positive regulation of cell size, positive regulation of epithelial cell proliferation, positive regulation of lamellipodium assembly, positive regulation of melanin biosynthetic process, positive regulation of response to wounding, positive regulation of vascular associated smooth muscle cell migration, pyramidal neuron development, regulation of gene expression, regulation of oxidative phosphorylation, release of cytochrome c from mitochondria, removal of superoxide radicals, response to copper ion, response to manganese ion, serotonin metabolic process, skin development, tyrosine metabolic process; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled monoatomic cation transmembrane transporter activity, P-type divalent copper transporter activity, P-type monovalent copper transporter activity, copper ion binding, copper ion transmembrane transporter activity, copper-dependent protein binding, cuprous ion binding, metal ion binding, nucleotide binding, protein binding, protein-folding chaperone binding, small GTPase binding, superoxide dismutase copper chaperone activity; CC: Golgi apparatus, apical plasma membrane, axon, basolateral plasma membrane, bounding membrane of organelle, brush border membrane, cell leading edge, cell projection, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendrite, early endosome membrane, endoplasmic reticulum, endosome, late endosome, melanosome membrane, membrane, microvillus, neuron projection, neuronal cell body, perikaryon, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, secretory granule, synapse, trans-Golgi network, trans-Golgi network membrane, trans-Golgi network transport vesicle
Pathways: Antimicrobial peptides, Immune System, Innate Immune System, Ion channel transport, Ion influx/efflux at host-pathogen interface, Ion transport by P-type ATPases, Mineral absorption - Mus musculus (mouse), Transport of small molecules, copper transport II
UniProt: Q64430
Entrez ID: 11977
|
Does Knockout of Ltc4s in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Ltc4s
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Ltc4s (leukotriene C4 synthase)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme that catalyzes the synthesis of leukotriene C4 by combining leukotriene A4 with reduced glutathione. The encoded protein is found in the outer nuclear membrane and in the peripheral endoplasmic reticulum. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as bronchial asthma in humans. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cellular oxidant detoxification, leukotriene biosynthetic process, leukotriene metabolic process, lipid metabolic process, long-chain fatty acid biosynthetic process; MF: enzyme activator activity, glutathione binding, glutathione peroxidase activity, glutathione transferase activity, identical protein binding, leukotriene-C4 synthase activity, lipid binding, lyase activity, protein-containing complex binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear envelope, nuclear membrane, nuclear outer membrane, nucleus
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biosynthesis of DHA-derived SPMs, Biosynthesis of DHA-derived sulfido conjugates, Biosynthesis of Lipoxins (LX), Biosynthesis of maresin conjugates in tissue regeneration (MCTR), Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR), Biosynthesis of specialized proresolving mediators (SPMs), Fatty acid metabolism, Metabolism, Metabolism of lipids, Synthesis of 5-eicosatetraenoic acids, Synthesis of Leukotrienes (LT) and Eoxins (EX)
UniProt: Q60860
Entrez ID: 17001
|
Does Knockout of Nob1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Nob1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nob1 (NIN1/RPN12 binding protein 1 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA, ribosomal small subunit biogenesis, visual perception; MF: RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, zinc ion binding; CC: cytoplasm, nucleolus, nucleus, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8BW10
Entrez ID: 67619
|
Does Knockout of Ost4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ost4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ost4 (oligosaccharyltransferase complex subunit 4 (non-catalytic))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, PD-L1(CD274) glycosylation and translocation to plasma membrane, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family
UniProt: Q99LX8
Entrez ID: 67695
|
Does Knockout of Zscan4f in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Zscan4f
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Zscan4f (zinc finger and SCAN domain containing 4F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of transcription by RNA polymerase II, telomere maintenance via telomere lengthening; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromosome, chromosome, telomeric region, nucleoplasm, nucleus
Pathways:
UniProt: Q3URS2
Entrez ID: 665902
|
Does Knockout of Snrnp70 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Snrnp70
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Snrnp70 (small nuclear ribonucleoprotein 70 (U1))
Type: protein-coding
Summary: This gene encodes a subunit of the U1 snRNP (small nuclear ribonucleic particle), one of at least five snRNPs to comprise the spliceosome, which functions in processing of pre-mRNAs. The U1 snRNP has been shown to be important in defining the 5' splice site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, mRNA splicing, via spliceosome, negative regulation of chaperone-mediated autophagy, negative regulation of protein refolding, positive regulation of mRNA splicing, via spliceosome, regulation of RNA splicing; MF: RNA binding, U1 snRNA binding, U1 snRNP binding, mRNA binding, nucleic acid binding; CC: U1 snRNP, U2-type prespliceosome, lysosomal lumen, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q62376
Entrez ID: 20637
|
Does Knockout of Oog3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Oog3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Oog3 (oogenesin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q3UWY1
Entrez ID: 100012
|
Does Knockout of Pde4a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Pde4a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pde4a (phosphodiesterase 4A, cAMP specific)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cAMP catabolic process, cellular response to xenobiotic stimulus, modulation of chemical synaptic transmission, negative regulation of cAMP/PKA signal transduction, regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of cAMP/PKA signal transduction, sensory perception of smell, signal transduction; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, TPR domain binding, cAMP binding, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity; CC: Schaffer collateral - CA1 synapse, cytoplasm, cytosol, extrinsic component of membrane, membrane, nucleoplasm, perinuclear region of cytoplasm, plasma membrane
Pathways: DARPP-32 events, G alpha (i) signalling events, G alpha (s) signalling events, GPCR downstream signalling, Morphine addiction - Mus musculus (mouse), Opioid Signalling, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: O89084
Entrez ID: 18577
|
Does Knockout of Aebp2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Aebp2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Aebp2 (AE binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, transcription coregulator activity, zinc ion binding; CC: ESC/E(Z) complex, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation of gene expression, Gene expression (Transcription), PKMTs methylate histone lysines, PRC2 methylates histones and DNA
UniProt: Q9Z248
Entrez ID: 11569
|
Does Knockout of Ap2s1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,286
|
Knockout
|
Ap2s1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ap2s1 (adaptor-related protein complex 2, sigma 1 subunit)
Type: protein-coding
Summary: Predicted to enable clathrin adaptor activity. Predicted to be involved in postsynaptic neurotransmitter receptor internalization and synaptic vesicle endocytosis. Part of AP-2 adaptor complex. Is active in synapse. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: clathrin-dependent endocytosis, endocytosis, intracellular protein transport, postsynaptic neurotransmitter receptor internalization, protein transport, synaptic vesicle endocytosis, vesicle-mediated transport; MF: clathrin adaptor activity, protein binding; CC: AP-2 adaptor complex, clathrin-coated pit, cytoplasmic side of plasma membrane, extrinsic component of presynaptic endocytic zone membrane, glutamatergic synapse, intracellular membrane-bounded organelle, membrane, membrane coat, plasma membrane, postsynapse, presynapse, synapse, synaptic vesicle
Pathways: Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, Huntington disease - Mus musculus (mouse), Immune System, L1CAM interactions, LDL clearance, MHC class II antigen presentation, Membrane Trafficking, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, PCP/CE pathway, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Recycling pathway of L1, Retrograde neurotrophin signalling, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by WNT, Synaptic vesicle cycle - Mus musculus (mouse), Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transmission across Chemical Synapses, Transport of small molecules, VLDLR internalisation and degradation, Vesicle-mediated transport, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, WNT5A-dependent internalization of FZD4
UniProt: P62743
Entrez ID: 232910
|
Does Knockout of Lsm7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Lsm7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lsm7 (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA catabolic process, mRNA processing, mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process; MF: RNA binding, protein binding, protein heterodimerization activity; CC: Lsm1-7-Pat1 complex, Lsm2-8 complex, U12-type spliceosomal complex, U2-type precatalytic spliceosome, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, catalytic step 2 spliceosome, cytoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q9CQQ8
Entrez ID: 66094
|
Does Knockout of Mbd2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Mbd2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Mbd2 (methyl-CpG binding domain protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cellular response to serotonin, chromatin remodeling, embryonic organ development, epigenetic regulation of gene expression, maternal behavior, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of Wnt signaling pathway, protein-containing complex assembly, regulation of cell population proliferation, regulation of transcription by RNA polymerase II, response to bisphenol A, response to estradiol, response to mechanical stimulus, response to nutrient levels, ventricular cardiac muscle tissue development; MF: C2H2 zinc finger domain binding, DNA binding, chromatin binding, identical protein binding, mRNA binding, methyl-CpG binding, molecular adaptor activity, protein binding, protein domain specific binding, siRNA binding; CC: NuRD complex, chromatin, chromosome, cytoplasm, cytosol, heterochromatin, histone deacetylase complex, nucleoplasm, nucleus
Pathways:
UniProt: Q9Z2E1
Entrez ID: 17191
|
Does Knockout of Ttc14 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ttc14
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ttc14 (tetratricopeptide repeat domain 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: nucleic acid binding, protein binding
Pathways:
UniProt: Q9CSP9
Entrez ID: 67120
|
Does Knockout of Gnal in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Gnal
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gnal (guanine nucleotide binding protein, alpha stimulating, olfactory type)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating dopamine receptor signaling pathway, cellular response to dopamine, regulation of long-term synaptic depression, response to amphetamine, response to caffeine, sensory perception of chemical stimulus, sensory perception of smell, signal transduction; MF: G protein activity, G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, guanyl nucleotide binding, hydrolase activity, metal ion binding, nucleotide binding; CC: acrosomal vesicle, apical cytoplasm, ciliary necklace, cilium, cytoplasm, heterotrimeric G-protein complex, membrane, plasma membrane, sperm midpiece
Pathways: Activation of GABAB receptors, Adenylate cyclase activating pathway, Adenylate cyclase inhibitory pathway, Amoebiasis - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), G alpha (i) signalling events, G-protein mediated events, GABA B receptor activation, GABA receptor activation, GPCR downstream signalling, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Olfactory Signaling Pathway, Olfactory transduction - Mus musculus (mouse), Opioid Signalling, Parkinson disease - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by GPCR, Transmission across Chemical Synapses
UniProt: Q8CGK7
Entrez ID: 14680
|
Does Knockout of Atp8b3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Atp8b3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Atp8b3 (ATPase, class I, type 8B, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, binding of sperm to zona pellucida, establishment of localization in cell, lipid transport, phospholipid translocation, phospholipid transport; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, magnesium ion binding, metal ion binding, nucleotide binding, phosphatidylserine floppase activity; CC: acrosomal membrane, acrosomal vesicle, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane, trans-Golgi network
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: Q6UQ17
Entrez ID: 67331
|
Does Knockout of Dennd1a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Dennd1a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Dennd1a (DENN domain containing 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, endocytosis, positive regulation of GTPase activity, protein transport, regulation of Rab protein signal transduction, synaptic vesicle endocytosis; MF: SH3 domain binding, guanyl-nucleotide exchange factor activity, lipid binding, phosphatidylinositol phosphate binding, phosphatidylinositol-3-phosphate binding, protein binding, small GTPase binding; CC: cell projection, clathrin-coated vesicle, clathrin-coated vesicle membrane, cytoplasmic vesicle, cytosol, dendrite, membrane, neuronal cell body, plasma membrane, presynaptic membrane, synapse
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q8K382
Entrez ID: 227801
|
Does Knockout of Kera in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Kera
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Kera (keratocan)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways: Glycosaminoglycan metabolism, Keratan sulfate biosynthesis, Keratan sulfate degradation, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: O35367
Entrez ID: 16545
|
Does Knockout of Aox3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Aox3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Aox3 (aldehyde oxidase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: 2 iron, 2 sulfur cluster binding, FAD binding, NAD binding, aldehyde oxidase activity, electron transfer activity, flavin adenine dinucleotide binding, iron ion binding, iron-sulfur cluster binding, metal ion binding, molybdenum ion binding, molybdopterin cofactor binding, oxidoreductase activity, protein homodimerization activity; CC: cytoplasm, cytosol
Pathways: Drug metabolism - cytochrome P450 - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Tryptophan metabolism - Mus musculus (mouse), Tyrosine metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), Vitamin B6 metabolism - Mus musculus (mouse)
UniProt: G3X982
Entrez ID: 71724
|
Does Knockout of Cog3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Cog3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cog3 (component of oligomeric golgi complex 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, glycosylation, intra-Golgi vesicle-mediated transport, intracellular protein transport, protein glycosylation, protein stabilization, protein transport, retrograde transport, vesicle recycling within Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; CC: Golgi apparatus, Golgi cisterna membrane, Golgi transport complex, cis-Golgi network, cytosol, membrane, plasma membrane
Pathways:
UniProt: Q3USH9, E9QL65
Entrez ID: 338337
|
Does Knockout of Acad11 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Acad11
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Acad11 (acyl-Coenzyme A dehydrogenase family, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carboxylic acid catabolic process, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty acid metabolic process, lipid metabolic process; MF: acyl-CoA dehydrogenase activity, flavin adenine dinucleotide binding, long-chain fatty acyl-CoA dehydrogenase activity, medium-chain fatty acyl-CoA dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, very-long-chain fatty acyl-CoA dehydrogenase activity; CC: cytoplasm, membrane, mitochondrial membrane, mitochondrion, nucleus, peroxisome
Pathways: Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, fatty acid β-oxidation I
UniProt: Q80XL6
Entrez ID: 102632
|
Does Knockout of Hic1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Hic1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Hic1 (hypermethylated in cancer 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of DNA damage response, signal transduction by p53 class mediator, regulation of signal transduction, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, histone deacetylase binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromatin, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription factors
UniProt: Q9R1Y5
Entrez ID: 15248
|
Does Knockout of Chmp1b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Chmp1b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Chmp1b (charged multivesicular body protein 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, cell division, endosome transport via multivesicular body sorting pathway, establishment of protein localization, late endosome to lysosome transport, late endosome to vacuole transport, membrane fission, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein transport, regulation of centrosome duplication, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; MF: MIT domain binding, identical protein binding, protein domain specific binding; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, cytoplasm, cytosol, endosome, endosome membrane, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, membrane coat, midbody, multivesicular body, multivesicular body membrane, nuclear pore, nucleoplasm, plasma membrane
Pathways: Endocytosis - Mus musculus (mouse), Necroptosis - Mus musculus (mouse)
UniProt: Q99LU0
Entrez ID: 67064
|
Does Knockout of Tpsg1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Tpsg1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tpsg1 (tryptase gamma 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular space, membrane
Pathways:
UniProt: E9QLD4, E0CXD8, E9Q7E3, A0AAA9WWG1, A0AAA9WW35
Entrez ID: 26945
|
Does Knockout of Ogdhl in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Ogdhl
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ogdhl (oxoglutarate dehydrogenase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate metabolic process, glycolytic process, tricarboxylic acid cycle; MF: metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamine pyrophosphate binding; CC: mitochondrial matrix, mitochondrion, oxoglutarate dehydrogenase complex
Pathways: Citrate cycle (TCA cycle) - Mus musculus (mouse)
UniProt: E9Q7L0, B2RXT3
Entrez ID: 239017
|
Does Knockout of 1700010D01Rik in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
1700010D01Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 1700010D01Rik (RIKEN cDNA 1700010D01 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 76386
|
Does Knockout of Qtrt1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Qtrt1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Qtrt1 (queuine tRNA-ribosyltransferase catalytic subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA modification, tRNA processing, tRNA wobble guanine modification; MF: glycosyltransferase activity, metal ion binding, protein binding, protein heterodimerization activity, protein homodimerization activity, tRNA-guanosine(34) queuine transglycosylase activity, transferase activity; CC: cytoplasm, cytoplasmic side of mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion, nucleus, protein-containing complex, tRNA-guanine transglycosylase complex, transferase complex
Pathways:
UniProt: Q9JMA2
Entrez ID: 60507
|
Does Knockout of Alas1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Alas1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Alas1 (aminolevulinic acid synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to insulin stimulus, erythrocyte development, heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, hemoglobin biosynthetic process, porphyrin-containing compound metabolic process, protoporphyrinogen IX biosynthetic process, response to bile acid, response to cAMP, response to cobalt ion, response to ethanol, response to gonadotropin, response to herbicide, response to hypoxia, response to nickel cation, response to nutrient levels, response to platinum ion, response to xenobiotic stimulus, tetrapyrrole biosynthetic process; MF: 5-aminolevulinate synthase activity, acyltransferase activity, identical protein binding, pyridoxal phosphate binding, transferase activity; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways: Glycine, serine and threonine metabolism - Mus musculus (mouse), Heme biosynthesis, Metabolism, Metabolism of porphyrins, Metabolism of proteins, Mitochondrial protein degradation, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, tetrapyrrole biosynthesis II
UniProt: Q8VC19
Entrez ID: 11655
|
Does Knockout of Vps18 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Vps18
|
cell cycle progression
|
breast epithelium
|
Gene: Vps18 (VPS18 CORVET/HOPS core subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, endosome organization, endosome to lysosome transport, intracellular protein transport, lysosome organization, negative regulation of intracellular estrogen receptor signaling pathway, organelle fusion, protein transport, protein ubiquitination, regulation of synaptic vesicle exocytosis, symbiont entry into host cell, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: actin binding, metal ion binding, protein binding, protein-macromolecule adaptor activity, syntaxin binding, ubiquitin protein ligase activity, zinc ion binding; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, actin filament, autophagosome, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endomembrane system, endosome, glutamatergic synapse, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, presynapse
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q8R307
Entrez ID: 228545
|
Does Knockout of Ints7 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ints7
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ints7 (integrator complex subunit 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, RNA polymerase II transcription initiation surveillance, cellular response to ionizing radiation, snRNA 3'-end processing, snRNA processing; CC: INTAC complex, chromosome, cytoplasm, integrator complex, nuclear body, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q7TQK1
Entrez ID: 77065
|
Does Knockout of Snap91 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Snap91
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Snap91 (synaptosomal-associated protein 91)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, chemical synaptic transmission, clathrin coat assembly, clathrin-dependent endocytosis, establishment or maintenance of cell polarity, neuron development, neurotransmitter secretion, positive regulation of axonogenesis, positive regulation of clathrin coat assembly, positive regulation of synaptic vesicle clustering, positive regulation of synaptic vesicle endocytosis, protein transport, regulation of clathrin-dependent endocytosis, regulation of endocytosis, regulation of protein transport, regulation of synaptic vesicle endocytosis, regulation of terminal button organization, synaptic vesicle endocytosis, vesicle budding from membrane; MF: 1-phosphatidylinositol binding, SH2 domain binding, SNARE binding, clathrin adaptor activity, clathrin binding, clathrin heavy chain binding, inositol hexakisphosphate binding, molecular adaptor activity, phosphatidylinositol-4,5-bisphosphate binding, phospholipase C inhibitor activity, phospholipase D inhibitor activity, phospholipase binding, phospholipid binding, protein binding, protein kinase binding; CC: AP-2 adaptor complex, Schaffer collateral - CA1 synapse, axon terminus, clathrin-coated pit, clathrin-coated vesicle, cytosol, extrinsic component of presynaptic endocytic zone membrane, membrane, neuronal cell body, parallel fiber to Purkinje cell synapse, plasma membrane, postsynaptic density, postsynaptic membrane, presynaptic active zone membrane, presynaptic membrane, synaptic vesicle
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q61548
Entrez ID: 20616
|
Does Knockout of Kif18b in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Kif18b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Kif18b (kinesin family member 18B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule depolymerization, microtubule-based movement, mitotic cell cycle, mitotic sister chromatid segregation, regulation of cell division; MF: ATP binding, ATP hydrolysis activity, cytoskeletal motor activity, kinesin binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity; CC: astral microtubule, cytoplasm, cytoskeleton, cytosol, kinesin complex, microtubule, microtubule end, microtubule plus-end, mitotic spindle astral microtubule, mitotic spindle midzone, nuclear body, nucleolus, nucleoplasm, nucleus, spindle
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q6PFD6
Entrez ID: 70218
|
Does Knockout of Sec24b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Sec24b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sec24b (SEC24 homolog B, COPII coat complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII-coated vesicle cargo loading, aorta morphogenesis, auditory receptor cell morphogenesis, auditory receptor cell stereocilium organization, circulatory system development, cochlear nucleus development, coronary artery morphogenesis, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, lung lobe morphogenesis, lung morphogenesis, neural tube closure, outflow tract morphogenesis, protein transport, pulmonary artery morphogenesis, regulation of cargo loading into COPII-coated vesicle, regulation of establishment of planar polarity involved in neural tube closure, vesicle-mediated transport; MF: SNARE binding, metal ion binding, protein binding, zinc ion binding; CC: COPII vesicle coat, COPII-coated ER to Golgi transport vesicle, ER to Golgi transport vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, membrane
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, Class I MHC mediated antigen processing & presentation, ER to Golgi Anterograde Transport, Immune System, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: F6YIN5, Q80ZX0, F6VJC5
Entrez ID: 99683
|
Does Knockout of Selenoi in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Selenoi
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Selenoi (selenoprotein I)
Type: protein-coding
Summary: The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: ether lipid biosynthetic process, lipid biosynthetic process, lipid metabolic process, myelination, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process; MF: ethanolaminephosphotransferase activity, metal ion binding, phosphotransferase activity, for other substituted phosphate groups, transferase activity; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Ether lipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Phosphonate and phosphinate metabolism - Mus musculus (mouse), Synthesis of PE, phosphatidylethanolamine biosynthesis II
UniProt: Q80TA1
Entrez ID: 28042
|
Does Knockout of Adtrp in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Adtrp
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adtrp (androgen dependent TFPI regulating protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration involved in sprouting angiogenesis, cellular response to oxidised low-density lipoprotein particle stimulus, cellular response to steroid hormone stimulus, lipid metabolic process, long-chain fatty acid catabolic process, negative regulation of blood coagulation, negative regulation of extracellular matrix constituent secretion, negative regulation of leukocyte cell-cell adhesion, negative regulation of leukocyte migration, negative regulation of lymphocyte migration, negative regulation of protein secretion, positive regulation of gene expression, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: hydrolase activity; CC: caveola, cell surface, endomembrane system, membrane, plasma membrane
Pathways:
UniProt: Q8C138
Entrez ID: 109254
|
Does Knockout of Gpr45 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Gpr45
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gpr45 (G protein-coupled receptor 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways: G alpha (s) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: Q9EQQ4
Entrez ID: 93690
|
Does Knockout of Kras in macrophage causally result in phagocytosis?
| 1
| 1,888
|
Knockout
|
Kras
|
phagocytosis
|
macrophage
|
Gene: Kras (Kirsten rat sarcoma viral oncogene homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, actin cytoskeleton organization, cardiac muscle cell proliferation, cytokine-mediated signaling pathway, epithelial tube branching involved in lung morphogenesis, female pregnancy, forebrain astrocyte development, gene expression, homeostasis of number of cells within a tissue, insulin-like growth factor receptor signaling pathway, liver development, myoblast proliferation, negative regulation of epithelial cell differentiation, negative regulation of neuron apoptotic process, positive regulation of Rac protein signal transduction, positive regulation of cellular senescence, positive regulation of gene expression, positive regulation of glial cell proliferation, regulation of long-term neuronal synaptic plasticity, regulation of synaptic transmission, GABAergic, response to glucocorticoid, response to gravity, response to isolation stress, response to mineralocorticoid, signal transduction, skeletal muscle cell differentiation, striated muscle cell differentiation, type I pneumocyte differentiation, visual learning; MF: G protein activity, GDP binding, GMP binding, GTP binding, GTPase activity, LRR domain binding, hydrolase activity, identical protein binding, nucleotide binding, protein binding, protein-containing complex binding, protein-membrane adaptor activity; CC: cytoplasm, cytoplasmic side of plasma membrane, endomembrane system, membrane, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Activation of RAS in B cells, Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Alcoholism - Mus musculus (mouse), Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Beta-catenin independent WNT signaling, Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, Ca2+ pathway, Cell surface interactions at the vascular wall, Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, Developmental Biology, Downstream signal transduction, Downstream signaling events of B Cell Receptor (BCR), Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, EGFR Transactivation by Gastrin, ESR-mediated signaling, Endometrial cancer - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Estrogen-stimulated signaling through PRKCZ, Extra-nuclear estrogen signaling, FCERI mediated MAPK activation, FLT3 Signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, FoxO signaling pathway - Mus musculus (mouse), G alpha (q) signalling events, GPCR downstream signalling, GRB2 events in EGFR signaling, GRB2 events in ERBB2 signaling, Gap junction - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Gastrin-CREB signalling pathway via PKC and MAPK, Glioma - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAP2K and MAPK activation, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, MET activates RAS signaling, Melanogenesis - Mus musculus (mouse), Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse), NCAM signaling for neurite out-growth, Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of MAPK pathway, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAF activation, RAF/MAP kinase cascade, RAS processing, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of RAS by GAPs, Regulation of actin cytoskeleton - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, SHC1 events in EGFR signaling, SHC1 events in ERBB4 signaling, Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Non-Receptor Tyrosine Kinases, Signaling by Nuclear Receptors, Signaling by PDGF, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling by VEGF, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Signalling to ERKs, Signalling to RAS, Sphingolipid signaling pathway - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Thyroid cancer - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Tie2 Signaling, VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated cell proliferation, Viral carcinogenesis - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse), p38MAPK events
UniProt: P32883
Entrez ID: 16653
|
Does Knockout of Rmi1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Rmi1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rmi1 (RecQ mediated genome instability 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, double-strand break repair via homologous recombination, glucose homeostasis, multicellular organism growth, reduction of food intake in response to dietary excess, resolution of DNA recombination intermediates, resolution of meiotic recombination intermediates, response to dietary excess, response to glucose; MF: molecular_function, nucleotide binding; CC: RecQ family helicase-topoisomerase III complex, nuclear body, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Transcriptional Regulation by TP53
UniProt: Q9D4G9
Entrez ID: 74386
|
Does Knockout of Slc6a14 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Slc6a14
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc6a14 (solute carrier family 6 (neurotransmitter transporter), member 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: (R)-carnitine transmembrane transport, alanine transport, amine transport, amino acid import across plasma membrane, amino acid transport, beta-alanine transport, branched-chain amino acid transport, chloride transport, glycine import across plasma membrane, response to toxic substance, sodium ion transmembrane transport; MF: (R)-carnitine transmembrane transporter activity, alanine transmembrane transporter activity, amine transmembrane transporter activity, aromatic amino acid transmembrane transporter activity, beta-alanine transmembrane transporter activity, branched-chain amino acid:sodium symporter activity, neutral, basic amino acid:sodium:chloride symporter activity, symporter activity; CC: apical plasma membrane, brush border membrane, membrane, plasma membrane
Pathways: Amino acid transport across the plasma membrane, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, SLC-mediated transport of neurotransmitters, Transport of small molecules
UniProt: Q9JMA9
Entrez ID: 56774
|
Does Knockout of Thrap3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Thrap3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Thrap3 (thyroid hormone receptor associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, circadian rhythm, mRNA processing, mRNA stabilization, nuclear-transcribed mRNA catabolic process, positive regulation of DNA-templated transcription, positive regulation of circadian rhythm, positive regulation of mRNA splicing, via spliceosome, positive regulation of transcription by RNA polymerase II, regulation of alternative mRNA splicing, via spliceosome, rhythmic process, transcription by RNA polymerase II; MF: ATP binding, DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, nuclear thyroid hormone receptor binding, nucleotide binding, phosphoprotein binding, protein binding, transcription coactivator activity, transcription coregulator activity; CC: exon-exon junction complex, mediator complex, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q569Z6
Entrez ID: 230753
|
Does Knockout of Zscan20 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Zscan20
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zscan20 (zinc finger and SCAN domains 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways:
UniProt: B2KFW1
Entrez ID: 269585
|
Does Knockout of Cyp2b9 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Cyp2b9
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cyp2b9 (cytochrome P450, family 2, subfamily b, polypeptide 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epoxygenase P450 pathway, ketone metabolic process, response to stilbenoid, steroid metabolic process, xenobiotic catabolic process, xenobiotic metabolic process; MF: anandamide 11,12 epoxidase activity, anandamide 14,15 epoxidase activity, anandamide 8,9 epoxidase activity, arachidonate epoxygenase activity, estrogen 2-hydroxylase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, testosterone 16-alpha-hydroxylase activity, testosterone 16-beta-hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: P12790
Entrez ID: 13094
|
Does Knockout of Dmap1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Dmap1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dmap1 (DNA methyltransferase 1-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of protein import into nucleus, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, response to ethanol; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, transcription corepressor activity; CC: NuA4 histone acetyltransferase complex, Swr1 complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleosome, nucleus, replication fork
Pathways:
UniProt: Q9JI44
Entrez ID: 66233
|
Does Knockout of Mfsd2b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Mfsd2b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mfsd2b (MFSD2 lysolipid transporter B, sphingolipid)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate transport, lipid transport, positive regulation of platelet aggregation, sphingosine-1-phosphate receptor signaling pathway, transmembrane transport; MF: sphingolipid transporter activity, symporter activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q3T9M1
Entrez ID: 432628
|
Does Knockout of Gnpat in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Gnpat
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gnpat (glyceronephosphate O-acyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellum morphogenesis, ether lipid biosynthetic process, glycerophospholipid metabolic process, lipid metabolic process, membrane organization, myelination, paranodal junction assembly, synapse assembly; MF: O-acyltransferase activity, acyltransferase activity, catalytic activity, glycerone-phosphate O-acyltransferase activity, protein binding, transferase activity; CC: cell junction, membrane, peroxisomal matrix, peroxisomal membrane, peroxisome
Pathways: Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Phospholipid metabolism, Plasmalogen biosynthesis, Protein localization, Synthesis of PA, Wax and plasmalogen biosynthesis
UniProt: P98192
Entrez ID: 14712
|
Does Knockout of Aire in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Aire
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Aire (autoimmune regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: central tolerance induction to self antigen, humoral immune response, immune response, negative thymic T cell selection, peripheral T cell tolerance induction, positive regulation of DNA-templated transcription, positive regulation of chemokine production, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of thymocyte migration, regulation of translation, thymus epithelium morphogenesis, tolerance induction; MF: DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, histone binding, identical protein binding, metal ion binding, translation regulator activity, zinc ion binding; CC: cytoplasm, female germ cell nucleus, male germ cell nucleus, nuclear body, nucleus
Pathways: Primary immunodeficiency - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9Z0E3
Entrez ID: 11634
|
Does Knockout of Bap1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Bap1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Bap1 (Brca1 associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell population proliferation, chromatin organization, common myeloid progenitor cell proliferation, erythrocyte differentiation, erythrocyte maturation, gene expression, granulocyte differentiation, hematopoietic stem cell homeostasis, heterochromatin formation, in utero embryonic development, leukocyte proliferation, macrophage homeostasis, mitotic cell cycle, monoubiquitinated protein deubiquitination, myeloid cell apoptotic process, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, neuron cellular homeostasis, neutrophil differentiation, nucleate erythrocyte differentiation, platelet morphogenesis, protein K48-linked deubiquitination, protein deubiquitination, proteolysis, regulation of cell cycle, regulation of cell growth, regulation of cytokine production involved in inflammatory response, regulation of gene expression, regulation of inflammatory response, thrombocyte differentiation, tissue homeostasis, ubiquitin-dependent protein catabolic process; MF: chromatin DNA binding, chromatin binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2A deubiquitinase activity, hydrolase activity, peptidase activity, protein binding; CC: PR-DUB complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, Metabolism of proteins, Post-translational protein modification, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, UCH proteinases
UniProt: Q99PU7
Entrez ID: 104416
|
Does Knockout of Oxr1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Oxr1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Oxr1 (oxidation resistance 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult walking behavior, cellular response to hydroperoxide, negative regulation of cellular response to oxidative stress, negative regulation of neuron apoptotic process, neuron apoptotic process, response to oxidative stress; CC: mitochondrion, nucleolus, nucleus
Pathways:
UniProt: Q4KMM3
Entrez ID: 170719
|
Does Knockout of Mxd4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Mxd4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mxd4 (Max dimerization protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity; CC: RNA polymerase II transcription regulator complex, nucleus
Pathways:
UniProt: Q3UZ22, Q91VN7
Entrez ID: 17122
|
Does Knockout of Mrpl43 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Mrpl43
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrpl43 (mitochondrial ribosomal protein L43)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways:
UniProt: Q5RL20
Entrez ID: 94067
|
Does Knockout of Nhej1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Nhej1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nhej1 (non-homologous end joining factor 1)
Type: protein-coding
Summary: Predicted to enable DNA end binding activity and DNA polymerase binding activity. Involved in double-strand break repair via nonhomologous end joining. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Predicted to be active in site of double-strand break. Human ortholog(s) of this gene implicated in severe combined immunodeficiency 124. Orthologous to human NHEJ1 (non-homologous end joining factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell differentiation, DNA damage response, DNA repair, T cell differentiation, double-strand break repair, double-strand break repair via nonhomologous end joining, immunoglobulin V(D)J recombination, response to ionizing radiation, telomere maintenance; MF: DNA binding, DNA end binding, DNA polymerase binding, protein binding; CC: DNA ligase IV complex, DNA-dependent protein kinase-DNA ligase 4 complex, chromosome, fibrillar center, nonhomologous end joining complex, nucleoplasm, nucleus, site of double-strand break
Pathways: DNA Double-Strand Break Repair, DNA Repair, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ)
UniProt: Q3KNJ2
Entrez ID: 75570
|
Does Knockout of Egr3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Egr3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Egr3 (early growth response 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration involved in sprouting angiogenesis, cellular response to fibroblast growth factor stimulus, cellular response to vascular endothelial growth factor stimulus, endothelial cell chemotaxis, negative regulation of apoptotic process, neuromuscular synaptic transmission, peripheral nervous system development, positive regulation of T cell differentiation in thymus, positive regulation of endothelial cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of gamma-delta T cell differentiation, regulation of transcription by RNA polymerase II, system development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleoplasm, nucleus, synapse
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: P43300
Entrez ID: 13655
|
Does Knockout of Rad17 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,550
|
Knockout
|
Rad17
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rad17 (RAD17 checkpoint clamp loader component)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and chromatin-protein adaptor activity. Predicted to contribute to DNA clamp loader activity. Acts upstream of or within DNA damage response. Predicted to be located in nucleoplasm. Predicted to be part of Rad17 RFC-like complex. Predicted to be active in site of double-strand break. Predicted to colocalize with chromosome, telomeric region. Is expressed in cerebral cortex; embryo; and telencephalon. Orthologous to human RAD17 (RAD17 checkpoint clamp loader component). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, chromatin organization, mitotic DNA replication checkpoint signaling, mitotic intra-S DNA damage checkpoint signaling, negative regulation of DNA replication, protein localization to site of double-strand break; MF: ATP binding, DNA clamp loader activity, chromatin binding, chromatin-protein adaptor activity, nucleotide binding; CC: Rad17 RFC-like complex, chromosome, chromosome, telomeric region, nucleolus, nucleoplasm, nucleus, site of double-strand break
Pathways: Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q6NXW6
Entrez ID: 19356
|
Does Knockout of Ang2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Ang2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ang2 (angiogenin, ribonuclease A family, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, angiotensin-activated signaling pathway, antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, cardiac muscle hypertrophy, cell growth involved in cardiac muscle cell development, cell migration, cellular response to glucose stimulus, cellular response to stress, cytoplasmic translation, defense response to Gram-positive bacterium, gene expression, hematopoietic stem cell proliferation, innate immune response, negative regulation of smooth muscle cell proliferation, negative regulation of translation in response to stress, positive regulation of endothelial cell proliferation, positive regulation of phosphorylation, positive regulation of protein secretion, rRNA transcription, receptor-mediated endocytosis, renal absorption, response to hormone, response to hypoxia, response to yeast, signal transduction, signaling, stress granule assembly, tRNA stabilization; MF: DNA binding, RNA nuclease activity, actin binding, copper ion binding, endonuclease activity, heparin binding, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, peptide binding, protein homodimerization activity, receptor ligand activity, ribosome binding, signaling receptor binding, tRNA-specific ribonuclease activity; CC: actin cytoskeleton, angiogenin-PRI complex, basement membrane, chromosome, cytoplasm, cytoplasmic stress granule, cytoplasmic vesicle, endocytic vesicle, extracellular region, extracellular space, nucleolus, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse)
UniProt: Q64438
Entrez ID: 11731
|
Does Knockout of Abhd16b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Abhd16b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Abhd16b (abhydrolase domain containing 16B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, monoacylglycerol catabolic process, phosphatidylserine catabolic process; MF: hydrolase activity, monoacylglycerol lipase activity, phospholipase activity; CC: nucleoplasm
Pathways:
UniProt: Q80YU0
Entrez ID: 241850
|
Does Knockout of Ttc39a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Ttc39a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ttc39a (tetratricopeptide repeat domain 39A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome
Pathways:
UniProt: A2ACP1
Entrez ID: 230603
|
Does Knockout of Fkbp11 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Fkbp11
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fkbp11 (FK506 binding protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: isomerase activity, peptidyl-prolyl cis-trans isomerase activity; CC: endoplasmic reticulum, membrane
Pathways:
UniProt: Q9D1M7
Entrez ID: 66120
|
Does Knockout of Itga8 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Itga8
|
cell cycle progression
|
breast epithelium
|
Gene: Itga8 (integrin alpha 8)
Type: protein-coding
Summary: This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: cell adhesion, cell differentiation, cell projection organization, cell-cell adhesion, cell-matrix adhesion, embryonic morphogenesis, establishment of protein localization, extracellular matrix organization, inner ear morphogenesis, integrin-mediated signaling pathway, kidney development, memory, mesodermal cell differentiation, metanephros development, nervous system development, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, smooth muscle cell differentiation, smooth muscle tissue development, substrate adhesion-dependent cell spreading, tissue development; MF: metal ion binding, signaling receptor activity; CC: apical part of cell, cell surface, dendritic spine membrane, endoplasmic reticulum, focal adhesion, glutamatergic synapse, integrin complex, membrane, perikaryon, plasma membrane, postsynaptic density membrane
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Elastic fibre formation, Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Integrin cell surface interactions, Molecules associated with elastic fibres, PI3K-Akt signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs
UniProt: A2ARA8
Entrez ID: 241226
|
Does Knockout of Edc3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Edc3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Edc3 (enhancer of mRNA decapping 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P-body assembly, deadenylation-independent decapping of nuclear-transcribed mRNA; MF: RNA binding, identical protein binding, mRNA binding; CC: P-body, cytoplasm, cytoplasmic ribonucleoprotein granule
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Mus musculus (mouse), mRNA decay by 5' to 3' exoribonuclease
UniProt: Q8K2D3
Entrez ID: 353190
|
Does Knockout of Ism1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ism1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ism1 (isthmin 1, angiogenesis inhibitor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of angiogenesis
Pathways:
UniProt: A2ATD1
Entrez ID: 319909
|
Does Knockout of Ptpa in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Ptpa
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ptpa (protein phosphatase 2 protein activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitotic spindle organization, positive regulation of apoptotic process; MF: ATP binding, isomerase activity, metal ion binding, nucleotide binding, peptidyl-prolyl cis-trans isomerase activity, phosphatase activator activity, phosphatase binding, phosphoprotein phosphatase activity, protein homodimerization activity, protein phosphatase 2A binding, protein phosphatase regulator activity, protein tyrosine phosphatase activator activity, signaling receptor binding; CC: ATPase complex, calcium channel complex, cytoplasm, nucleoplasm, nucleus, protein phosphatase type 2A complex
Pathways: Diabetic cardiomyopathy - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse)
UniProt: P58389
Entrez ID: 110854
|
Does Knockout of Stam in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Stam
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Stam (signal transducing adaptor molecule (SH3 domain and ITAM motif) 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: macroautophagy, multivesicular body assembly, positive regulation of exosomal secretion, protein transport, protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, regulation of extracellular exosome assembly; MF: phosphatidylinositol binding, protein binding, ubiquitin binding, ubiquitin-like protein ligase binding; CC: ESCRT-0 complex, cytoplasm, cytosol, early endosome membrane, endosome, membrane
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Deubiquitination, EGFR downregulation, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), JAK-STAT signaling pathway - Mus musculus (mouse), Membrane Trafficking, Metabolism of proteins, Metalloprotease DUBs, Negative regulation of MET activity, Post-translational protein modification, RHO GTPase cycle, RHOU GTPase cycle, Signal Transduction, Signaling by EGFR, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: P70297
Entrez ID: 20844
|
Does Knockout of Ikbke in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ikbke
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ikbke (inhibitor of kappaB kinase epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, activation of innate immune response, cellular response to virus, gene expression, immune response, interleukin-17-mediated signaling pathway, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to DNA damage, mRNA stabilization, positive regulation of canonical NF-kappaB signal transduction, positive regulation of gene expression, positive regulation of lipid storage, positive regulation of type I interferon production, positive regulation of type I interferon-mediated signaling pathway, regulation of protein-containing complex assembly, response to cytokine, response to interferon-beta, response to stress, response to type I interferon, type I interferon-mediated signaling pathway; MF: ATP binding, IkappaB kinase activity, K48-linked polyubiquitin modification-dependent protein binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, ubiquitin protein ligase binding; CC: PML body, cytoplasm, mitochondrial membrane, nucleus
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Alcoholic liver disease - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytosolic DNA-sensing pathway - Mus musculus (mouse), DDX58/IFIH1-mediated induction of interferon-alpha/beta, Death Receptor Signaling, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, MyD88-independent TLR4 cascade , NOD-like receptor signaling pathway - Mus musculus (mouse), Negative regulators of DDX58/IFIH1 signaling, Post-translational protein modification, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TNFR1 signaling, Response of endothelial cells to shear stress, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of immune response proteins, Signal Transduction, TNF signaling, TNFR1-induced proapoptotic signaling, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
UniProt: Q9R0T8
Entrez ID: 56489
|
Does Knockout of B3galt4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
B3galt4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: B3galt4 (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ganglioside biosynthetic process, lipid metabolic process, protein O-linked glycosylation, protein glycosylation; MF: N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity, ganglioside galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Blood group systems biosynthesis, Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - ganglio series - Mus musculus (mouse), Glycosphingolipid metabolism, Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of lipids, Sphingolipid metabolism
UniProt: Q9Z0F0
Entrez ID: 54218
|
Does Knockout of Sccpdh in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Sccpdh
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Sccpdh (saccharopine dehydrogenase (putative))
Type: protein-coding
Summary: Predicted to enable oxidoreductase activity. Predicted to be involved in glycolipid biosynthetic process. Located in mitochondrion. Is expressed in brain. Orthologous to human SCCPDH (saccharopine dehydrogenase (putative)). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: molecular_function, oxidoreductase activity; CC: lipid droplet, membrane, midbody, mitochondrion
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, lysine degradation II
UniProt: Q8R127
Entrez ID: 109232
|
Does Knockout of Vmn1r94 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Vmn1r94
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r94 (vomeronasal 1 receptor 94)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: K7N6X3
Entrez ID: 620537
|
Does Knockout of Tst in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Tst
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Tst (thiosulfate sulfurtransferase, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial cell differentiation, rRNA import into mitochondrion, rRNA transport; MF: 3-mercaptopyruvate sulfurtransferase activity, 5S rRNA binding, RNA binding, sulfurtransferase activity, thiosulfate-cyanide sulfurtransferase activity, transferase activity; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Degradation of cysteine and homocysteine, Metabolism, Metabolism of amino acids and derivatives, Sulfur amino acid metabolism, Sulfur metabolism - Mus musculus (mouse), Sulfur relay system - Mus musculus (mouse), thiosulfate disproportionation III (rhodanese)
UniProt: P52196
Entrez ID: 22117
|
Does Knockout of Jph1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Jph1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Jph1 (junctophilin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Z disc, endoplasmic reticulum, endoplasmic reticulum membrane, junctional membrane complex, junctional sarcoplasmic reticulum membrane, membrane, nucleoplasm, plasma membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways:
UniProt: Q9ET80
Entrez ID: 57339
|
Does Knockout of Slc16a3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Slc16a3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc16a3 (solute carrier family 16 (monocarboxylic acid transporters), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lactate transmembrane transport, monocarboxylic acid transport, plasma membrane lactate transport, pyruvate catabolic process, pyruvate transmembrane transport, transmembrane transport; MF: lactate transmembrane transporter activity, lactate:proton symporter activity, monocarboxylic acid transmembrane transporter activity, pyruvate transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, lateral plasma membrane, membrane, nuclear membrane, plasma membrane
Pathways: Basigin interactions, Cell surface interactions at the vascular wall, Central carbon metabolism in cancer - Mus musculus (mouse), Hemostasis, Proton-coupled monocarboxylate transport, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: P57787
Entrez ID: 80879
|
Does Knockout of Pnrc2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Pnrc2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pnrc2 (proline-rich nuclear receptor coactivator 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA metabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; CC: Golgi apparatus, P-body, cytoplasm, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD)
UniProt: Q9CR73
Entrez ID: 52830
|
Does Knockout of Zwint in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Zwint
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Zwint (ZW10 interactor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, establishment of localization in cell, homologous chromosome orientation in meiotic metaphase I, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, regulation of meiosis I spindle assembly checkpoint; CC: Knl1/Spc105 complex, chromosome, chromosome, centromeric region, cytoplasm, cytosol, dendrite, kinetochore, nuclear body, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CQU5
Entrez ID: 52696
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.