prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Mrpl33 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Mrpl33
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrpl33 (mitochondrial ribosomal protein L33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; CC: cytosol, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CQP0
Entrez ID: 66845
|
Does Knockout of Taar9 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Taar9
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Taar9 (trace amine-associated receptor 9)
Type: protein-coding
Summary: Enables trace-amine receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Is active in plasma membrane. Is expressed in olfactory epithelium. Orthologous to human TAAR9 (trace amine associated receptor 9). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled amine receptor activity, G protein-coupled receptor activity, trace-amine receptor activity; CC: membrane, plasma membrane
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q5QD04
Entrez ID: 503558
|
Does Knockout of Slc16a12 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Slc16a12
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Slc16a12 (solute carrier family 16 (monocarboxylic acid transporters), member 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: creatine transmembrane transport, creatinine metabolic process, transmembrane transport; MF: creatine transmembrane transporter activity, transmembrane transporter activity, uniporter activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q8BGC3
Entrez ID: 240638
|
Does Knockout of Gabpa in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gabpa
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gabpa (GA repeat binding protein, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, cell differentiation, in utero embryonic development, negative regulation of megakaryocyte differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Mitochondrial biogenesis, Organelle biogenesis and maintenance, Transcriptional activation of mitochondrial biogenesis
UniProt: Q00422
Entrez ID: 14390
|
Does Knockout of Cdc45 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Cdc45
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cdc45 (cell division cycle 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA replication initiation, double-strand break repair via break-induced replication, mitotic DNA replication preinitiation complex assembly; MF: DNA replication origin binding, chromatin binding, single-stranded DNA binding; CC: CMG complex, DNA replication preinitiation complex, centrosome, ciliary basal body, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition
UniProt: Q9Z1X9
Entrez ID: 12544
|
Does Knockout of Tpm1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Tpm1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tpm1 (tropomyosin 1, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament capping, actin filament organization, cardiac muscle contraction, in utero embryonic development, muscle filament sliding, negative regulation of cell migration, negative regulation of vascular associated smooth muscle cell migration, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of cell adhesion, positive regulation of heart rate by epinephrine, positive regulation of stress fiber assembly, regulation of cell shape, ruffle organization, sarcomere organization, ventricular cardiac muscle tissue morphogenesis, wound healing; MF: actin binding, actin filament binding, cytoskeletal protein binding, disordered domain specific binding, identical protein binding, protein binding, protein heterodimerization activity, protein homodimerization activity, structural constituent of cytoskeleton; CC: actin cytoskeleton, actin filament, bleb, cytoplasm, cytoskeleton, cytosol, muscle thin filament tropomyosin, myofibril, protein-containing complex, ruffle membrane, stress fiber
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Muscle contraction, Smooth Muscle Contraction, Striated Muscle Contraction
UniProt: P58771
Entrez ID: 22003
|
Does Knockout of Mrpl12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Mrpl12
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mrpl12 (mitochondrial ribosomal protein L12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial transcription, mitochondrial translation, positive regulation of DNA-templated transcription, translation; MF: mRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial matrix, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9DB15
Entrez ID: 56282
|
Does Knockout of Mbp in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Mbp
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mbp (myelin basic protein)
Type: protein-coding
Summary: The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called 'Golli-Mbp') that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, maintenance of blood-brain barrier, membrane organization, myelination, negative regulation of axonogenesis, negative regulation of heterotypic cell-cell adhesion, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of interleukin-6 production, response to progesterone, response to toxic substance, sensory perception of sound; MF: calmodulin binding, lipid binding, protease binding, structural constituent of myelin sheath; CC: cell periphery, cell projection, cell surface, compact myelin, cytoplasm, internode region of axon, membrane, myelin sheath, neuronal cell body, nucleus, plasma membrane, protein-containing complex
Pathways:
UniProt: P04370
Entrez ID: 17196
|
Does Knockout of Nudt1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,525
|
Knockout
|
Nudt1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Nudt1 (nudix hydrolase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA protection, purine nucleoside catabolic process; MF: 2-hydroxy-ATP hydrolase activity, 2-hydroxy-dATP hydrolase activity, 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity, 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity, 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity, ATP diphosphatase activity, N6-methyl-(d)ATP hydrolase activity, O6-methyl-dGTP hydrolase activity, RNA binding, dATP diphosphatase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, metal ion binding, snoRNA binding; CC: acrosomal vesicle, cytoplasm, cytoplasmic vesicle, cytosol, extracellular space, membrane, mitochondrial matrix, mitochondrion, nuclear membrane, nucleus
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Phosphate bond hydrolysis by NUDT proteins, Purine catabolism
UniProt: P53368
Entrez ID: 17766
|
Does Knockout of Mpst in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Mpst
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Mpst (mercaptopyruvate sulfurtransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hydrogen sulfide biosynthetic process, kidney development, liver development, spinal cord development, transsulfuration; MF: 3-mercaptopyruvate sulfurtransferase activity, identical protein binding, sulfurtransferase activity, thiosulfate-cyanide sulfurtransferase activity, transferase activity; CC: cytoplasm, mitochondrial inner membrane, mitochondrion, neuron projection, synapse
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Degradation of cysteine and homocysteine, L-cysteine degradation III, Metabolism, Metabolism of amino acids and derivatives, Sulfur amino acid metabolism, Sulfur metabolism - Mus musculus (mouse), Sulfur relay system - Mus musculus (mouse)
UniProt: Q99J99
Entrez ID: 246221
|
Does Knockout of Msh5 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Msh5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Msh5 (mutS homolog 5)
Type: protein-coding
Summary: This gene encodes a member of the MutS family of proteins that play critical roles in DNA mismatch repair and meiotic homologous recombination processes. Mice lacking the encoded protein are viable but sterile, with severe defects in spermatogenesis in males and complete loss of ovarian structures in females. Mutations in a similar gene in humans have been shown to cause common variable immune deficiency (CVID) and immunoglobulin A deficiency. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: DNA damage response, DNA repair, chiasma assembly, female gamete generation, homologous chromosome pairing at meiosis, meiosis I, meiotic cell cycle, mismatch repair; MF: ATP binding, ATP-dependent DNA damage sensor activity, DNA binding, double-stranded DNA binding, mismatched DNA binding, nucleotide binding; CC: nucleoplasm, nucleus, synaptonemal complex
Pathways:
UniProt: Q9QUM7
Entrez ID: 17687
|
Does Knockout of Ddx42 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Ddx42
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ddx42 (DEAD box helicase 42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: U2-type prespliceosome assembly, intracellular protein localization, regulation of apoptotic process; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: U2-type prespliceosome, cytoplasm, cytosol, nuclear speck, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q810A7
Entrez ID: 72047
|
Does Knockout of Rprm in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Rprm
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rprm (reprimo, TP53 dependent G2 arrest mediator candidate)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of cell cycle, regulation of mitotic cell cycle; CC: cytoplasm, membrane
Pathways: p53 signaling pathway - Mus musculus (mouse)
UniProt: Q9JJ72
Entrez ID: 67874
|
Does Knockout of Zer1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Zer1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zer1 (zyg-11 related, cell cycle regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins; CC: Cul2-RING ubiquitin ligase complex
Pathways:
UniProt: Q80ZJ6
Entrez ID: 227693
|
Does Knockout of Nmt1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Nmt1
|
cell cycle progression
|
breast epithelium
|
Gene: Nmt1 (N-myristoyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-terminal peptidyl-glycine N-myristoylation, cellular response to nutrient levels, in utero embryonic development, ketone metabolic process, positive regulation of TORC1 signaling, positive regulation of protein localization to lysosome, protein localization to membrane; MF: acyltransferase activity, glycylpeptide N-tetradecanoyltransferase activity, myristoyltransferase activity, peptidyl-lysine N6-myristoyltransferase activity, transferase activity; CC: cytoplasm, cytosol, membrane, plasma membrane
Pathways:
UniProt: O70310
Entrez ID: 18107
|
Does Knockout of Supt20 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Supt20
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Supt20 (SPT20 SAGA complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gastrulation, positive regulation of DNA-templated transcription, positive regulation of gluconeogenesis, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of RNA splicing, regulation of transcription by RNA polymerase II; MF: transcription coregulator activity; CC: SAGA complex, SAGA-type complex
Pathways: Autophagy - animal - Mus musculus (mouse)
UniProt: Q7TT00
Entrez ID: 56790
|
Does Knockout of Vmn1r51 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Vmn1r51
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Vmn1r51 (vomeronasal 1 receptor 51)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8VIC6
Entrez ID: 22296
|
Does Knockout of Setd7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Setd7
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Setd7 (SET domain containing (lysine methyltransferase) 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, chromatin organization, chromatin remodeling, heterochromatin organization, methylation, negative regulation of DNA repair, peptidyl-lysine dimethylation, peptidyl-lysine monomethylation, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of DNA-templated transcription, response to alcohol, response to ethanol; MF: chromatin binding, histone H3 methyltransferase activity, histone H3K4 monomethyltransferase activity, histone methyltransferase activity, methyltransferase activity, p53 binding, protein binding, protein-lysine N-methyltransferase activity, transferase activity; CC: chromosome, nucleolus, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, FoxO signaling pathway - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse), PKMTs methylate histone lysines
UniProt: Q8VHL1
Entrez ID: 73251
|
Does Knockout of Tk1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Tk1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tk1 (thymidine kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA synthesis involved in mitotic DNA replication, deoxyribonucleoside monophosphate biosynthetic process, protein homotetramerization, thymidine biosynthetic process, thymidine metabolic process; MF: ATP binding, identical protein binding, kinase activity, metal ion binding, nucleotide binding, thymidine kinase activity, transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleus
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide salvage, Pyrimidine metabolism - Mus musculus (mouse), Pyrimidine salvage, purine and pyrimidine metabolism, salvage pathways of pyrimidine deoxyribonucleotides
UniProt: P04184
Entrez ID: 21877
|
Does Knockout of Anapc4 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Anapc4
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Anapc4 (anaphase promoting complex subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of mitotic metaphase/anaphase transition; MF: protein phosphatase binding; CC: anaphase-promoting complex, nuclear periphery, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q91W96
Entrez ID: 52206
|
Does Knockout of Eif4g3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Eif4g3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eif4g3 (eukaryotic translation initiation factor 4 gamma, 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of meiosis I, positive regulation of translation, regulation of translation, spermatid development, spermatogenesis, translation, translational initiation; MF: RNA binding, mRNA binding, protein binding, translation initiation factor activity; CC: eukaryotic translation initiation factor 4F complex, synapse
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, ISG15 antiviral mechanism, Immune System, Interferon Signaling, Viral myocarditis - Mus musculus (mouse)
UniProt: Q80XI3
Entrez ID: 230861
|
Does Knockout of Uspl1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Uspl1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Uspl1 (ubiquitin specific peptidase like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Cajal body organization, blastocyst formation, cell population proliferation, protein desumoylation, proteolysis, snRNA transcription; MF: SUMO binding, cysteine-type peptidase activity, deSUMOylase activity, hydrolase activity, peptidase activity; CC: Cajal body, nucleus
Pathways:
UniProt: Q3ULM6
Entrez ID: 231915
|
Does Knockout of Med6 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Med6
|
phagocytosis
|
macrophage
|
Gene: Med6 (mediator complex subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance; MF: DNA binding, protein binding, transcription coactivator activity, transcription coactivator binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways:
UniProt: Q921D4
Entrez ID: 69792
|
Does Knockout of Atg5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,288
|
Knockout
|
Atg5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atg5 (autophagy related 5)
Type: protein-coding
Summary: The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: aggrephagy, antigen processing and presentation of endogenous antigen, apoptotic process, autophagosome assembly, autophagy, axonal transport, blood vessel remodeling, cellular response to nitrogen starvation, cellular response to nitrosative stress, cellular response to starvation, chaperone-mediated autophagy, chromatin organization, defense response to virus, establishment of localization in cell, heart contraction, immune system process, innate immune response, macroautophagy, mitophagy, negative regulation of apoptotic process, negative regulation of autophagic cell death, negative regulation of cardiac muscle cell apoptotic process, negative regulation of defense response to virus, negative regulation of innate immune response, negative regulation of phagocytosis, negative regulation of protein ubiquitination, negative regulation of type I interferon production, negative stranded viral RNA replication, negative thymic T cell selection, otolith development, piecemeal microautophagy of the nucleus, positive regulation of autophagy, positive regulation of mucus secretion, positive regulation of stress granule assembly, positive regulation of viral translation, post-translational protein modification, postsynaptic modulation of chemical synaptic transmission, regulation of autophagosome maturation, regulation of cilium assembly, regulation of cytokine production involved in immune response, regulation of organelle assembly, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of reactive oxygen species metabolic process, regulation of release of sequestered calcium ion into cytosol, response to fluoride, response to fungus, response to iron(II) ion, response to xenobiotic stimulus, vasodilation, ventricular cardiac muscle cell development; MF: Atg8-family ligase activity, protein binding; CC: Atg12-Atg5-Atg16 complex, Schaffer collateral - CA1 synapse, autophagosome, axon, axoneme, cytoplasm, cytosol, glutamatergic synapse, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, phagophore, phagophore assembly site membrane, postsynapse, protein-containing complex, synapse, transferase complex
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Ferroptosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Macroautophagy, Mitophagy, Mitophagy - animal - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), PINK1-PRKN Mediated Mitophagy, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Receptor Mediated Mitophagy, Selective autophagy
UniProt: Q99J83
Entrez ID: 11793
|
Does Knockout of Rps4x in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Rps4x
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rps4x (ribosomal protein S4, X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, positive regulation of cell population proliferation, positive regulation of translation, ribosomal small subunit biogenesis, translation; MF: RNA binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62702
Entrez ID: 20102
|
Does Knockout of Slc30a9 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Slc30a9
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Slc30a9 (solute carrier family 30 (zinc transporter), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular zinc ion homeostasis, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transport, positive regulation of transcription by RNA polymerase II, regulation of mitochondrion organization, transmembrane transport, zinc ion transmembrane transport, zinc ion transport; MF: antiporter activity, chromatin binding, monoatomic cation transmembrane transporter activity, nuclear receptor binding, transcription coactivator activity, zinc ion transmembrane transporter activity; CC: cytoplasm, cytoplasmic vesicle, cytoskeleton, endoplasmic reticulum, membrane, mitochondrial membrane, mitochondrion, nucleus
Pathways:
UniProt: Q5IRJ6
Entrez ID: 109108
|
Does Knockout of Cebpe in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Cebpe
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cebpe (CCAAT/enhancer binding protein epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, cellular response to lipopolysaccharide, granulocyte differentiation, macrophage differentiation, myeloid cell differentiation, phagocytosis, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein-containing complex binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, nucleoplasm, nucleus, plasma membrane
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q6PZD9
Entrez ID: 110794
|
Does Knockout of B4galnt3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
B4galnt3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: B4galnt3 (beta-1,4-N-acetyl-galactosaminyl transferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity, acetylgalactosaminyltransferase activity, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity, glycosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, membrane
Pathways: Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q6L8S8
Entrez ID: 330406
|
Does Knockout of Rbbp8 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Rbbp8
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Rbbp8 (retinoblastoma binding protein 8, endonuclease)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA double-strand break processing involved in repair via single-strand annealing, DNA repair, DNA strand resection involved in replication fork processing, G1/S transition of mitotic cell cycle, blastocyst hatching, cell division, double-strand break repair via homologous recombination, homologous recombination, meiotic cell cycle, mitotic G2/M transition checkpoint, negative regulation of DNA-templated transcription; MF: DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, damaged DNA binding, endonuclease activity, hydrolase activity, identical protein binding, nuclease activity, single-stranded DNA endodeoxyribonuclease activity, transcription corepressor activity; CC: BRCA1-C complex, chromosome, nucleoplasm, nucleus, site of double-strand break, transcription repressor complex
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through MMEJ (alt-NHEJ), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Transcriptional Regulation by TP53
UniProt: Q80YR6
Entrez ID: 225182
|
Does Knockout of Kansl2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Kansl2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kansl2 (KAT8 regulatory NSL complex subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription; CC: NSL complex, actin cytoskeleton, cytosol, histone acetyltransferase complex, mitochondrion, nucleoplasm, nucleus, plasma membrane
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones
UniProt: Q8BQR4
Entrez ID: 69612
|
Does Knockout of Irf1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Irf1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Irf1 (interferon regulatory factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, alpha-beta T cell differentiation, apoptotic process, canonical NF-kappaB signal transduction, cellular response to interferon-beta, cellular response to interleukin-1, cellular response to mechanical stimulus, cellular response to peptide hormone stimulus, cellular response to tumor necrosis factor, defense response to virus, immune system process, innate immune response, negative regulation of DNA-templated transcription, negative regulation of T-helper 2 cell differentiation, negative regulation of regulatory T cell differentiation, positive regulation of DNA-templated transcription, positive regulation of T-helper 1 cell differentiation, positive regulation of apoptotic process, positive regulation of interferon-beta production, positive regulation of interleukin-12 production, positive regulation of natural killer cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of type I interferon production, regulation of CD8-positive, alpha-beta T cell proliferation, regulation of DNA-templated transcription, regulation of MyD88-dependent toll-like receptor signaling pathway, regulation of adaptive immune response, regulation of cell cycle, regulation of gene expression, regulation of innate immune response, regulation of transcription by RNA polymerase II, response to growth hormone, toll-like receptor 3 signaling pathway, type II interferon-mediated signaling pathway; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, nucleus
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: P15314
Entrez ID: 16362
|
Does Knockout of Agr2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Agr2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Agr2 (anterior gradient 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, digestive tract morphogenesis, endoplasmic reticulum unfolded protein response, inflammatory response, lung goblet cell differentiation, mucus secretion, positive regulation of IRE1-mediated unfolded protein response, positive regulation of PERK-mediated unfolded protein response, positive regulation of cell-substrate adhesion, positive regulation of developmental growth, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of gene expression, positive regulation of protein localization to plasma membrane, protein folding in endoplasmic reticulum; MF: dystroglycan binding, epidermal growth factor receptor binding, identical protein binding, protein binding, protein homodimerization activity; CC: endoplasmic reticulum, extracellular region, extracellular space, mitochondrion
Pathways:
UniProt: O88312
Entrez ID: 23795
|
Does Knockout of Golga4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Golga4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Golga4 (golgin A4)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane protein transport and positive regulation of axon extension. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GOLGA4 (golgin A4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi vesicle transport, positive regulation of axon extension; MF: GTPase binding, small GTPase binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, membrane, nucleoplasm
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q91VW5
Entrez ID: 54214
|
Does Knockout of Pmp22 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Pmp22
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Pmp22 (peripheral myelin protein 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell development, Schwann cell differentiation, Schwann cell migration, actin cytoskeleton organization, adult locomotory behavior, adult walking behavior, aggresome assembly, apoptotic process, autophagy, axon development, basement membrane organization, bleb assembly, cell adhesion, cell differentiation, cellular response to heat, cellular response to unfolded protein, cholesterol metabolic process, fibroblast migration, gliogenesis, immune response, lamellipodium assembly, lipid metabolic process, mating, membrane raft organization, motor behavior, multicellular organism growth, muscle cell development, myelin assembly, myelination, myelination in peripheral nervous system, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of neuron projection development, nervous system development, neuromuscular junction development, skeletal muscle fiber, neuromuscular process, neuronal action potential, neuronal action potential propagation, neuronal ion channel clustering, paranodal junction assembly, peripheral nervous system development, peripheral nervous system neuron axonogenesis, positive regulation of gene expression, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of Schwann cell proliferation, regulation of apoptotic signaling pathway, regulation of cell cycle, regulation of gene expression, regulation of glial cell apoptotic process, regulation of inflammatory response, response to bacterium, response to endoplasmic reticulum stress, striated muscle cell differentiation, transmission of nerve impulse, vestibular reflex; MF: cytoskeletal motor activity, protein binding, protein serine/threonine kinase inhibitor activity; CC: bicellular tight junction, cell surface, compact myelin, integrin complex, laminin complex, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: P16646
Entrez ID: 18858
|
Does Knockout of Hbb-bs in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Hbb-bs
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hbb-bs (hemoglobin, beta adult s chain)
Type: protein-coding
Summary: This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a 'single' haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a 'diffuse' haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta s adult gene found in the 'single' haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the 'single' haplotype, while the 'diffuse' haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013].
Gene Ontology:
Pathways: African trypanosomiasis - Mus musculus (mouse), Binding and Uptake of Ligands by Scavenger Receptors, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Erythrocytes take up carbon dioxide and release oxygen, Erythrocytes take up oxygen and release carbon dioxide, Heme signaling, Immune System, Innate Immune System, Malaria - Mus musculus (mouse), Neutrophil degranulation, O2/CO2 exchange in erythrocytes, Scavenging of heme from plasma, Transport of small molecules, Vesicle-mediated transport
UniProt: E9Q223, A8DUK4
Entrez ID: 100503605
|
Does Knockout of Lamtor1 in Regulatory T cell causally result in cell proliferation?
| 1
| 2,127
|
Knockout
|
Lamtor1
|
cell proliferation
|
Regulatory T cell
|
Gene: Lamtor1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, autophagosome assembly, cellular response to amino acid stimulus, cellular response to nutrient levels, cholesterol homeostasis, cytoplasmic translation, endosomal transport, endosome organization, intracellular protein localization, lysosome localization, lysosome organization, negative regulation of autophagy, negative regulation of translational initiation, positive regulation of MAPK cascade, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of protein localization to lysosome, positive regulation of translational initiation, protein localization to lysosome, protein localization to membrane, regulation of cell growth, regulation of cholesterol efflux, regulation of cholesterol import, regulation of receptor recycling; MF: GTPase binding, guanyl-nucleotide exchange factor activity, molecular adaptor activity, protein binding, protein-membrane adaptor activity; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, membrane raft
Pathways: Amino acids regulate mTORC1, Autophagy, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, Neutrophil degranulation, PIP3 activates AKT signaling, PTEN Regulation, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOG GTPase cycle, RHOH GTPase cycle, RHOQ GTPase cycle, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q9CQ22
Entrez ID: 66508
|
Does Knockout of Lrp2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Lrp2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Lrp2 (low density lipoprotein receptor-related protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alcohol metabolic process, amyloid-beta clearance, aorta development, cardiac septum development, cell population proliferation, cellular response to growth factor stimulus, chemoattraction of axon, coronary artery morphogenesis, coronary vasculature development, cranial skeletal system development, diol metabolic process, endocytic hemoglobin import into cell, endocytosis, endosomal transport, epithelium development, folate import across plasma membrane, forebrain development, gene expression, heart development, kidney development, male gonad development, metal ion transport, negative regulation of BMP signaling pathway, negative regulation of apoptotic process, negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway, nervous system development, neural tube closure, neuron projection arborization, neuron projection morphogenesis, outflow tract morphogenesis, outflow tract septum morphogenesis, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of endocytosis, positive regulation of lipoprotein transport, positive regulation of neurogenesis, positive regulation of oligodendrocyte progenitor proliferation, protein import, protein transport, pulmonary artery morphogenesis, receptor-mediated endocytosis, response to X-ray, response to leptin, secondary heart field specification, sensory perception of sound, transcytosis, tube development, vagina development, ventricular compact myocardium morphogenesis, ventricular septum development, vitamin D metabolic process, vitamin transport; MF: PDZ domain binding, SH3 domain binding, calcium ion binding, cargo receptor activity, hemoglobin binding, hormone binding, insulin-like growth factor I binding, low-density lipoprotein particle receptor binding, metal ion binding, nuclear receptor binding, protein binding, protein transporter activity, protein-containing complex binding, protein-folding chaperone binding; CC: Golgi apparatus, apical part of cell, apical plasma membrane, axon, axonal growth cone, brush border, brush border membrane, cell projection, cell surface, clathrin-coated pit, dendrite, endocytic vesicle, endoplasmic reticulum, endosome, endosome lumen, external side of plasma membrane, extracellular space, membrane, plasma membrane, protein-containing complex, receptor complex
Pathways: Cargo recognition for clathrin-mediated endocytosis, Cholesterol metabolism - Mus musculus (mouse), Clathrin-mediated endocytosis, Cobalamin (Cbl, vitamin B12) transport and metabolism, Hedgehog signaling pathway - Mus musculus (mouse), Membrane Trafficking, Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Retinoid metabolism and transport, Sensory Perception, Thyroid hormone synthesis - Mus musculus (mouse), Transport of RCbl within the body, Vesicle-mediated transport, Visual phototransduction
UniProt: A2ARV4
Entrez ID: 14725
|
Does Knockout of Lypd8 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Lypd8
|
cell cycle progression
|
breast epithelium
|
Gene: Lypd8 (LY6/PLAUR domain containing 8)
Type: protein-coding
Summary: This gene encodes a member of the Ly6/PLAUR family of cysteine-rich proteins that plays an important role in the protection of colonic epithelium from flagellated microbiota. The encoded protein undergoes proteolytic processing to generate a mature, glycosylphosphatidylinositol-anchored protein that is localized to the apical surface of the colonic epithelial cells. Mice lacking the encoded protein are sensitive to chemically induced intestinal inflammation. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: defense response to Gram-negative bacterium; CC: extracellular region, extracellular space, membrane, plasma membrane, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q9D7S0
Entrez ID: 70163
|
Does Knockout of Fam53a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Fam53a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fam53a (family with sequence similarity 53, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein import into nucleus; CC: nucleus
Pathways:
UniProt: E9PV82
Entrez ID: 74504
|
Does Knockout of Stmnd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Stmnd1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Stmnd1 (stathmin domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6P3A1
Entrez ID: 380842
|
Does Knockout of Il3 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Il3
|
cell proliferation
|
Regulatory T cell
|
Gene: Il3 (interleukin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via STAT, cytokine-mediated signaling pathway, embryonic hemopoiesis, extrinsic apoptotic signaling pathway in absence of ligand, hemopoiesis, immune response, interleukin-3-mediated signaling pathway, monocyte differentiation, myeloid cell apoptotic process, negative regulation of B cell apoptotic process, negative regulation of autophagy, negative regulation of mast cell apoptotic process, negative regulation of myeloid cell apoptotic process, positive regulation of B cell proliferation, positive regulation of JNK cascade, positive regulation of T cell proliferation, positive regulation of cell population proliferation, positive regulation of hematopoietic progenitor cell differentiation, positive regulation of mast cell proliferation, positive regulation of myeloid leukocyte differentiation, regulation of cell growth, regulation of gene expression, regulation of glycolytic process, response to hormone, response to hypoxia; MF: cytokine activity, growth factor activity, interleukin-3 receptor binding; CC: extracellular region, extracellular space
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Asthma - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Immune System, Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, JAK-STAT signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Signal Transduction, Signaling by Interleukins, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P01586
Entrez ID: 16187
|
Does Knockout of Polr2e in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Polr2e
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Polr2e (polymerase (RNA) II (DNA directed) polypeptide E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, tRNA transcription by RNA polymerase III, transcription by RNA polymerase II, transcription elongation by RNA polymerase I; MF: DNA binding, DNA-directed RNA polymerase activity; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, RNA polymerase II, core complex, RNA polymerase III complex, RPAP3/R2TP/prefoldin-like complex, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Cytosolic DNA-sensing pathway - Mus musculus (mouse), DNA Repair, Dual incision in TC-NER, ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, FGFR2 alternative splicing, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism of RNA, Nucleotide Excision Repair, Positive epigenetic regulation of rRNA expression, Processing of Capped Intron-Containing Pre-mRNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q80UW8
Entrez ID: 66420
|
Does Knockout of Pcdh9 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Pcdh9
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcdh9 (protocadherin 9)
Type: protein-coding
Summary: This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. These proteins mediate cell adhesion in neural tissues in the presence of calcium. The encoded protein may be involved in signaling at neuronal synaptic junctions. Sharing a characteristic with other protocadherin genes, this gene has a notably large exon that encodes multiple cadherin domains and a transmembrane region. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, protein binding; CC: cell-cell contact zone, glutamatergic synapse, growth cone, membrane, plasma membrane, synaptic membrane
Pathways:
UniProt: A0A0A6YWY8, F8VPK8, A0A0A6YY37, A0A0A6YY09, A0A0A6YWM0, A0A0A6YVP5
Entrez ID: 211712
|
Does Knockout of Exosc10 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Exosc10
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Exosc10 (exosome component 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CUT catabolic process, DNA damage response, DNA repair, RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), histone mRNA catabolic process, maturation of 5.8S rRNA, negative regulation of telomere maintenance via telomerase, nuclear mRNA surveillance, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent antisense transcript catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent snRNA catabolic process, nuclear polyadenylation-dependent snoRNA catabolic process, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nucleobase-containing compound metabolic process, poly(A)-dependent snoRNA 3'-end processing, positive regulation of mRNA cis splicing, via spliceosome, rRNA processing, random inactivation of X chromosome, regulation of gene expression, regulation of nucleobase-containing compound metabolic process, regulation of telomerase RNA localization to Cajal body, ribosomal small subunit biogenesis; MF: 3'-5' exonuclease activity, 3'-5'-RNA exonuclease activity, RNA binding, RNA exonuclease activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, single-stranded RNA binding, telomerase RNA binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, euchromatin, exosome (RNase complex), nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P56960
Entrez ID: 50912
|
Does Knockout of 9330182O14Rik in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
9330182O14Rik
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: 9330182O14Rik (RIKEN cDNA 9330182O14 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: J3QNB2
Entrez ID: 328531
|
Does Knockout of Kdm1b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Kdm1b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kdm1b (lysine (K)-specific demethylase 1B)
Type: protein-coding
Summary: Enables FAD-dependent H3K4me/H3K4me3 demethylase activity; flavin adenine dinucleotide binding activity; and zinc ion binding activity. Involved in genomic imprinting. Acts upstream of or within epigenetic programing of female pronucleus. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human KDM1B (lysine demethylase 1B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromatin organization, epigenetic programing of female pronucleus, epigenetic regulation of gene expression, genomic imprinting, transcription initiation-coupled chromatin remodeling; MF: FAD binding, FAD-dependent H3K4me/H3K4me3 demethylase activity, flavin adenine dinucleotide binding, histone H3K4 demethylase activity, histone H3K4me/H3K4me2/H3K4me3 demethylase activity, histone binding, metal ion binding, oxidoreductase activity, protein binding, zinc ion binding; CC: chromatin, chromosome, nucleoplasm, nucleosome, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Deubiquitination, HDMs demethylate histones, Metabolism of proteins, Post-translational protein modification, UCH proteinases
UniProt: Q8CIG3
Entrez ID: 218214
|
Does Knockout of Rpia in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Rpia
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rpia (ribose 5-phosphate isomerase A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-ribose metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch; MF: carbohydrate binding, identical protein binding, isomerase activity, monosaccharide binding, ribose-5-phosphate isomerase activity; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), pentose phosphate pathway, pentose phosphate pathway (non-oxidative branch)
UniProt: P47968
Entrez ID: 19895
|
Does Knockout of Tirap in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Tirap
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tirap (toll-interleukin 1 receptor (TIR) domain-containing adaptor protein)
Type: protein-coding
Summary: Enables several functions, including Toll-like receptor 2 binding activity; identical protein binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of innate immune response; and regulation of cytokine production. Acts upstream of or within several processes, including myeloid cell differentiation; positive regulation of macrophage cytokine production; and response to bacterium. Located in endocytic vesicle and ruffle membrane. Is expressed in testis. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, TIRAP-dependent toll-like receptor 4 signaling pathway, cell surface receptor signaling pathway, cellular response to bacterial lipopeptide, cellular response to lipoteichoic acid, defense response to Gram-positive bacterium, immune system process, inflammatory response, innate immune response, interleukin-1-mediated signaling pathway, myeloid cell differentiation, positive regulation of B cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of canonical NF-kappaB signal transduction, positive regulation of chemokine (C-X-C motif) ligand 1 production, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of innate immune response, positive regulation of interleukin-12 production, positive regulation of interleukin-15 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of macrophage cytokine production, positive regulation of neutrophil chemotaxis, positive regulation of protein-containing complex assembly, positive regulation of toll-like receptor 2 signaling pathway, positive regulation of toll-like receptor 3 signaling pathway, positive regulation of toll-like receptor 4 signaling pathway, positive regulation of tumor necrosis factor production, regulation of innate immune response, regulation of interferon-beta production, regulation of interleukin-15 production, response to bacterium, response to lipopolysaccharide, signal transduction, toll-like receptor 4 signaling pathway, toll-like receptor 5 signaling pathway; MF: Toll-like receptor 2 binding, Toll-like receptor 4 binding, identical protein binding, molecular adaptor activity, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein kinase C binding, signaling adaptor activity; CC: cell surface, cytoplasm, endocytic vesicle, extrinsic component of cytoplasmic side of plasma membrane, membrane, peroxisome, plasma membrane, ruffle membrane
Pathways: Alcoholic liver disease - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Immune System, Innate Immune System, Lipid and atherosclerosis - Mus musculus (mouse), MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kappa B signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q99JY1
Entrez ID: 117149
|
Does Knockout of Pi4k2a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Pi4k2a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pi4k2a (phosphatidylinositol 4-kinase type 2 alpha)
Type: protein-coding
Summary: Predicted to enable 1-phosphatidylinositol 4-kinase activity; AP-3 adaptor complex binding activity; and ATP binding activity. Predicted to be involved in several processes, including basophil degranulation; endosome organization; and phosphatidylinositol phosphate biosynthetic process. Located in several cellular components, including dendrite; neuronal cell body; and presynaptic membrane. Is active in glutamatergic synapse and presynaptic active zone. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human PI4K2A (phosphatidylinositol 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi organization, basophil degranulation, endosome organization, lipid metabolic process, phosphatidylinositol biosynthetic process, phosphatidylinositol phosphate biosynthetic process; MF: 1-phosphatidylinositol 4-kinase activity, AP-3 adaptor complex binding, ATP binding, kinase activity, nucleotide binding, protein-containing complex binding, transferase activity; CC: BLOC-1 complex, Golgi apparatus, Golgi membrane, cell projection, cytoplasmic vesicle, dendrite, early endosome membrane, endosome, endosome membrane, exocytic vesicle, glutamatergic synapse, growing cell tip, membrane, membrane raft, mitochondrion, neuron projection, neuronal cell body, perikaryon, plasma membrane, presynaptic active zone, presynaptic membrane, protein-containing complex, synapse, synaptic vesicle membrane, trans-Golgi network
Pathways: 3-phosphoinositide biosynthesis, D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the plasma membrane
UniProt: Q2TBE6
Entrez ID: 84095
|
Does Knockout of Hpn in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Hpn
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hpn (hepsin)
Type: protein-coding
Summary: This gene encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Deficiency in this gene results in hearing loss. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: basement membrane disassembly, cholesterol homeostasis, cochlea morphogenesis, detection of mechanical stimulus involved in sensory perception of sound, epithelium development, host-mediated activation of viral transcription, negative regulation of apoptotic process, negative regulation of epithelial cell proliferation, negative regulation of epithelial to mesenchymal transition, pilomotor reflex, positive regulation of cell growth, positive regulation of gene expression, positive regulation of hepatocyte proliferation, positive regulation of plasminogen activation, positive regulation of thyroid hormone generation, potassium ion transmembrane transport, protein processing, proteolysis, regulation of biological quality, regulation of cell shape, response to thyroid hormone, sensory perception of sound; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type exopeptidase activity, serine-type peptidase activity; CC: apical plasma membrane, cell surface, cell-cell junction, cytoplasm, endoplasmic reticulum membrane, extracellular region, membrane, neuronal cell body, nuclear membrane, plasma membrane
Pathways: MET Receptor Activation, Signal Transduction, Signaling by MET, Signaling by MST1, Signaling by Receptor Tyrosine Kinases, Viral carcinogenesis - Mus musculus (mouse)
UniProt: O35453
Entrez ID: 15451
|
Does Knockout of Dnmt3b in Lung Cancer Cell Line causally result in tumorigenicity?
| 1
| 1,089
|
Knockout
|
Dnmt3b
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Dnmt3b (DNA methyltransferase 3B)
Type: protein-coding
Summary: This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, autosome genomic imprinting, cellular response to amino acid stimulus, developmental process involved in reproduction, epigenetic programming of gene expression, epigenetic regulation of gene expression, gamete generation, gene silencing by piRNA-directed DNA methylation, heterochromatin formation, methylation, negative regulation of DNA-templated transcription, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, oocyte development, positive regulation of gene expression, positive regulation of neuron differentiation, protein-containing complex localization, regulation of gene expression, transposable element silencing by heterochromatin formation; MF: DNA (cytosine-5-)-methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates, DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates, DNA binding, DNA-methyltransferase activity, chromatin binding, histone deacetylase binding, lncRNA binding, metal ion binding, methyltransferase activity, protein binding, transcription corepressor activity, transferase activity, zinc ion binding; CC: catalytic complex, chromosome, centromeric region, heterochromatin, nucleoplasm, nucleus
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Epigenetic regulation of gene expression, Gene expression (Transcription), Metabolism of proteins, MicroRNAs in cancer - Mus musculus (mouse), PRC2 methylates histones and DNA, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA methylation proteins
UniProt: O88509
Entrez ID: 13436
|
Does Knockout of Mxra8 in Pancreatic Cell Line causally result in cell proliferation?
| 0
| 2,193
|
Knockout
|
Mxra8
|
cell proliferation
|
Pancreatic Cell Line
|
Gene: Mxra8 (matrix-remodelling associated 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell differentiation, establishment of glial blood-brain barrier; CC: anchoring junction, bicellular tight junction, cell projection, cell surface, ciliary membrane, cytoplasm, membrane, nucleus, plasma membrane
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q9DBV4
Entrez ID: 74761
|
Does Knockout of Rai1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Rai1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Rai1 (retinoic acid induced 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian regulation of gene expression, negative regulation of multicellular organism growth, positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, rhythmic process, skeletal system development; MF: metal ion binding, zinc ion binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q61818
Entrez ID: 19377
|
Does Knockout of Elac2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Elac2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Elac2 (elaC ribonuclease Z 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial tRNA 3'-end processing, tRNA processing; MF: 3'-tRNA processing endoribonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, tRNA-specific ribonuclease activity; CC: mitochondrial nucleoid, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q80Y81
Entrez ID: 68626
|
Does Knockout of Raf1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Raf1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Raf1 (v-raf-leukemia viral oncogene 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERBB2-ERBB3 signaling pathway, MAPK cascade, Schwann cell development, cell differentiation, death-inducing signaling complex assembly, face development, insulin receptor signaling pathway, insulin secretion involved in cellular response to glucose stimulus, insulin-like growth factor receptor signaling pathway, intermediate filament cytoskeleton organization, intracellular glucose homeostasis, intracellular signal transduction, myelination, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of protein-containing complex assembly, neurotrophin TRK receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of transcription by RNA polymerase II, response to hypoxia, response to muscle stretch, signal transduction, somatic stem cell population maintenance, thymus development, thyroid gland development, type B pancreatic cell proliferation; MF: ATP binding, MAP kinase kinase kinase activity, adenylate cyclase activator activity, adenylate cyclase binding, enzyme binding, identical protein binding, kinase activity, metal ion binding, mitogen-activated protein kinase kinase binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, small GTPase binding, transferase activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytosol, membrane, mitochondrion, nucleus, plasma membrane, pseudopodium
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Alcoholism - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Axon guidance - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Cytokine Signaling in Immune system, Endometrial cancer - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), GP1b-IX-V activation signalling, Gap junction - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IFNG signaling activates MAPKs, Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Insulin signaling pathway - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, Ion channel transport, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAP2K and MAPK activation, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanogenesis - Mus musculus (mouse), Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative feedback regulation of MAPK pathway, Negative regulation of MAPK pathway, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation, signaling and aggregation, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAF activation, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Rap1 signalling, Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Stimuli-sensing channels, T cell receptor signaling pathway - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Transport of small molecules, Tuberculosis - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q99N57
Entrez ID: 110157
|
Does Knockout of Pou5f1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Pou5f1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Pou5f1 (POU domain, class 5, transcription factor 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein plays a key role in embryonic development and stem cell pluripotency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: blastocyst development, blastocyst growth, cell fate commitment, cellular response to leukemia inhibitory factor, chromatin organization, ectodermal cell fate commitment, endodermal cell fate commitment, endodermal cell fate specification, gene expression, germ-line stem cell population maintenance, intracellular receptor signaling pathway, mesodermal cell fate commitment, negative regulation of DNA-templated transcription, negative regulation of calcium ion-dependent exocytosis, negative regulation of cell differentiation, negative regulation of gene expression, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of DNA-templated transcription, regulation of asymmetric cell division, regulation of transcription by RNA polymerase II, response to benzoic acid, response to cytokine, response to retinoic acid, somatic stem cell population maintenance, stem cell differentiation, stem cell population maintenance, telomere maintenance, transcription by RNA polymerase II, trophectodermal cell differentiation, trophectodermal cell fate commitment; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, HMG box domain binding, POU domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, cytokine binding, histone H3K56ac reader activity, miRNA binding, nuclear receptor activity, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, ubiquitin protein ligase binding; CC: chromatin, cytoplasm, cytosol, female germ cell nucleus, germ cell nucleus, male germ cell nucleus, mitochondrion, nucleolus, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: P20263
Entrez ID: 18999
|
Does Knockout of Dctn3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,287
|
Knockout
|
Dctn3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dctn3 (dynactin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cytoskeleton-dependent cytokinesis, microtubule-based process; CC: centrosome, chromosome, chromosome, centromeric region, cleavage furrow, cytoplasm, cytoskeleton, cytosol, dynactin complex, kinetochore, microtubule, microtubule associated complex, midbody, nucleolus, perinuclear region of cytoplasm, spindle
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Amyotrophic lateral sclerosis - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Mus musculus (mouse), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Salmonella infection - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9Z0Y1
Entrez ID: 53598
|
Does Knockout of Gtf2h4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Gtf2h4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gtf2h4 (general transcription factor II H, polypeptide 4)
Type: protein-coding
Summary: This gene encodes a subunit of the general transcription factor multiprotein complex that plays roles in basal transcription, DNA repair and cell cycle control. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: DNA damage response, DNA repair, nucleotide-excision repair, transcription by RNA polymerase II; MF: ATPase activator activity, RNA polymerase II general transcription initiation factor activity, double-stranded DNA binding; CC: core TFIIH complex portion of holo TFIIH complex, nuclear speck, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Mus musculus (mouse), DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral carcinogenesis - Mus musculus (mouse), mRNA Capping
UniProt: O70422
Entrez ID: 14885
|
Does Knockout of Itch in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Itch
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Itch (itchy, E3 ubiquitin protein ligase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CXCL12-activated CXCR4 signaling pathway, apoptotic process, cytoplasmic pattern recognition receptor signaling pathway, defense response to virus, immune system process, innate immune response, negative regulation of CD4-positive, alpha-beta T cell proliferation, negative regulation of JNK cascade, negative regulation of apoptotic process, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cytoplasmic pattern recognition receptor signaling pathway, negative regulation of defense response to virus, negative regulation of immune system process, negative regulation of intracellular signal transduction, negative regulation of multicellular organismal process, positive regulation of T cell anergy, positive regulation of catabolic process, positive regulation of immune system process, positive regulation of macromolecule metabolic process, positive regulation of protein catabolic process, positive regulation of receptor catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K29-linked ubiquitination, protein K48-linked ubiquitination, protein K63-linked ubiquitination, protein autoubiquitination, protein branched polyubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, receptor internalization, regulation of gene expression, regulation of protein deubiquitination, response to oxidative stress, ubiquitin-dependent protein catabolic process; MF: CXCR chemokine receptor binding, arrestin family protein binding, catalytic activity, ligase activity, protein binding, ribonucleoprotein complex binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-like protein ligase binding, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity; CC: cell cortex, cell periphery, cytoplasm, cytoplasmic vesicle, cytosol, early endosome, early endosome membrane, endosome, endosome membrane, membrane, nucleoplasm, nucleus, plasma membrane, protein-containing complex, ubiquitin ligase complex
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Degradation of GLI1 by the proteasome, Downregulation of ERBB4 signaling, Endocytosis - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Immune System, Innate Immune System, NOD1/2 Signaling Pathway, Non-alcoholic fatty liver disease - Mus musculus (mouse), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Programmed Cell Death, RIPK1-mediated regulated necrosis, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulated Necrosis, Regulation of necroptotic cell death, Signal Transduction, Signaling by ERBB4, Signaling by Hedgehog, Signaling by NOTCH, Signaling by NOTCH1, Signaling by Receptor Tyrosine Kinases, TNF signaling pathway - Mus musculus (mouse), Transcriptional regulation by RUNX1, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8C863
Entrez ID: 16396
|
Does Knockout of Trim80 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Trim80
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Trim80 (tripartite motif-containing 80)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, immune system process, innate immune response; MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q3V061
Entrez ID: 432613
|
Does Knockout of Arap1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Arap1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arap1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of stress fiber assembly, photoreceptor cell maintenance, positive regulation of DNA-templated transcription, positive regulation of cellular component organization, positive regulation of filopodium assembly, positive regulation of phagocytosis, positive regulation of receptor recycling, regulation of actin cytoskeleton organization, regulation of bone resorption, regulation of cell projection organization, regulation of cell shape, regulation of endocytosis, regulation of receptor internalization, signal transduction, transforming growth factor beta receptor signaling pathway; MF: DNA-binding transcription factor activity, GTPase activator activity, R-SMAD binding, RNA polymerase II-specific DNA-binding transcription factor binding, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding, transcription cis-regulatory region binding, type 1 angiotensin receptor binding, zinc ion binding; CC: Golgi apparatus, Golgi cisterna membrane, anchoring junction, cell projection, cytoplasm, cytosol, early endosome, endosome, extrinsic component of plasma membrane, membrane, multivesicular body, nucleoplasm, plasma membrane, podosome, ruffle, trans-Golgi network
Pathways: CDC42 GTPase cycle, Endocytosis - Mus musculus (mouse), PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q4LDD4
Entrez ID: 69710
|
Does Knockout of Anapc7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Anapc7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Anapc7 (anaphase promoting complex subunit 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, brain development, cell division, positive regulation of mitotic metaphase/anaphase transition, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination; MF: enzyme-substrate adaptor activity, protein phosphatase binding; CC: anaphase-promoting complex, cytoplasm, cytoskeleton, heterochromatin, intercellular bridge, microtubule cytoskeleton, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9WVM3
Entrez ID: 56317
|
Does Knockout of Gpr20 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Gpr20
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gpr20 (G protein-coupled receptor 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane, receptor complex
Pathways: G alpha (s) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: Q8BYC4
Entrez ID: 239530
|
Does Knockout of Kpna2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Kpna2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Kpna2 (karyopherin subunit alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, entry of viral genome into host nucleus through nuclear pore complex via importin, non-canonical NF-kappaB signal transduction, positive regulation of DNA-templated transcription, positive regulation of type I interferon production, positive regulation of viral life cycle, postsynapse to nucleus signaling pathway, protein import into nucleus, protein transport, regulation of transcription by glucose; MF: DNA-binding transcription factor binding, histone deacetylase binding, nuclear import signal receptor activity, nuclear localization sequence binding, protein binding; CC: NLS-dependent protein nuclear import complex, cytoplasm, cytoplasmic stress granule, cytosol, glutamatergic synapse, host cell, nuclear membrane, nucleoplasm, nucleus, postsynaptic density
Pathways: Chemical carcinogenesis - receptor activation - Mus musculus (mouse), DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Influenza A - Mus musculus (mouse), Nucleocytoplasmic transport - Mus musculus (mouse), Sensing of DNA Double Strand Breaks
UniProt: P52293
Entrez ID: 16647
|
Does Knockout of Il3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Il3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Il3 (interleukin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via STAT, cytokine-mediated signaling pathway, embryonic hemopoiesis, extrinsic apoptotic signaling pathway in absence of ligand, hemopoiesis, immune response, interleukin-3-mediated signaling pathway, monocyte differentiation, myeloid cell apoptotic process, negative regulation of B cell apoptotic process, negative regulation of autophagy, negative regulation of mast cell apoptotic process, negative regulation of myeloid cell apoptotic process, positive regulation of B cell proliferation, positive regulation of JNK cascade, positive regulation of T cell proliferation, positive regulation of cell population proliferation, positive regulation of hematopoietic progenitor cell differentiation, positive regulation of mast cell proliferation, positive regulation of myeloid leukocyte differentiation, regulation of cell growth, regulation of gene expression, regulation of glycolytic process, response to hormone, response to hypoxia; MF: cytokine activity, growth factor activity, interleukin-3 receptor binding; CC: extracellular region, extracellular space
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Asthma - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Immune System, Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, JAK-STAT signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Signal Transduction, Signaling by Interleukins, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P01586
Entrez ID: 16187
|
Does Knockout of Mir434 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mir434
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mir434 (microRNA 434)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cellular hyperosmotic salinity response, cellular response to leukemia inhibitory factor, long-term synaptic potentiation, miRNA-mediated post-transcriptional gene silencing, sensory perception of sound
Pathways:
UniProt:
Entrez ID: 723867
|
Does Knockout of Gimap4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Gimap4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gimap4 (GTPase, IMAP family member 4)
Type: protein-coding
Summary: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. This gene exists within a cluster of other related genes located on mouse chromosome 6. This family member encodes a lymphoid signaling protein that functions to accelerate programmed T-cell death, which appears to correlate with the phosphorylation status of the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gene Ontology: MF: GTP binding, GTPase activity, nucleotide binding; CC: cytoplasm, cytosol
Pathways:
UniProt: Q99JY3
Entrez ID: 107526
|
Does Knockout of Mettl17 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Mettl17
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mettl17 (methyltransferase like 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial small ribosomal subunit assembly, ribosomal small subunit biogenesis, translation; MF: 4 iron, 4 sulfur cluster binding, S-adenosyl-L-methionine binding, iron-sulfur cluster binding, metal ion binding, methyltransferase activity, mitochondrial ribosome binding, small molecule binding; CC: intracellular organelle lumen, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways:
UniProt: Q3U2U7
Entrez ID: 52535
|
Does Knockout of Sumf2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Sumf2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sumf2 (sulfatase modifying factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: enzyme inhibitor activity, identical protein binding, metal ion binding, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum lumen
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Metabolism of proteins, Post-translational protein modification, Sphingolipid metabolism, The activation of arylsulfatases
UniProt: Q8BPG6
Entrez ID: 67902
|
Does Knockout of Pard3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Pard3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Pard3 (par-3 family cell polarity regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apical constriction, bicellular tight junction assembly, cell adhesion, cell differentiation, cell division, cell-cell adhesion, centrosome localization, establishment of cell polarity, establishment of centrosome localization, establishment of epithelial cell polarity, establishment or maintenance of cell polarity, establishment or maintenance of epithelial cell apical/basal polarity, intracellular protein localization, microtubule cytoskeleton organization, myelination in peripheral nervous system, negative regulation of peptidyl-threonine phosphorylation, positive regulation of myelination, positive regulation of receptor internalization, protein targeting to membrane, regulation of actin filament-based process, regulation of cellular localization, wound healing, spreading of cells; MF: identical protein binding, lipid binding, phosphatidylinositol binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein phosphatase binding; CC: PAR polarity complex, Schmidt-Lanterman incisure, adherens junction, anchoring junction, apical junction complex, apical plasma membrane, axonal growth cone, bicellular tight junction, cell cortex, cell junction, cell-cell junction, cytoplasm, cytoskeleton, endomembrane system, internode region of axon, lateral loop, membrane, neuronal cell body, plasma membrane, protein-containing complex, spindle
Pathways: Adherens junction - Mus musculus (mouse), Axon guidance - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: Q99NH2
Entrez ID: 93742
|
Does Knockout of Bcorl1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Bcorl1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Bcorl1 (BCL6 co-repressor-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of transcription by RNA polymerase II; CC: nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: A2AQH4
Entrez ID: 320376
|
Does Knockout of Tmem41b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Tmem41b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tmem41b (transmembrane protein 41B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, host-mediated perturbation of viral RNA genome replication, intracellular lipid transport, lipid transport, nervous system development, plasma membrane phospholipid scrambling; MF: phospholipid scramblase activity; CC: endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondria-associated endoplasmic reticulum membrane contact site
Pathways:
UniProt: Q8K1A5
Entrez ID: 233724
|
Does Knockout of Tm4sf5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Tm4sf5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tm4sf5 (transmembrane 4 superfamily member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of G1/S transition of mitotic cell cycle; MF: arginine binding; CC: lysosomal membrane, membrane, plasma membrane
Pathways:
UniProt: Q9D8G1, Q91XF2
Entrez ID: 75604
|
Does Knockout of Pten in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Pten
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pten (phosphatase and tensin homolog)
Type: protein-coding
Summary: This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: adult behavior, angiogenesis, apoptotic process, brain morphogenesis, cardiac muscle tissue development, cell migration, cell motility, cellular response to decreased oxygen levels, cellular response to electrical stimulus, cellular response to ethanol, cellular response to hypoxia, cellular response to insulin stimulus, cellular response to insulin-like growth factor stimulus, cellular response to leptin stimulus, central nervous system development, central nervous system myelin maintenance, central nervous system neuron axonogenesis, dendritic spine morphogenesis, dentate gyrus development, endothelial cell migration, forebrain morphogenesis, gene expression, heart development, inositol phosphate catabolic process, learning or memory, lipid metabolic process, locomotor rhythm, locomotory behavior, long-term synaptic depression, long-term synaptic potentiation, male mating behavior, maternal behavior, memory, multicellular organismal response to stress, negative regulation of B cell proliferation, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell proliferation, negative regulation of TORC1 signaling, negative regulation of androgen receptor signaling pathway, negative regulation of apoptotic process, negative regulation of axon regeneration, negative regulation of axonogenesis, negative regulation of cardiac muscle cell proliferation, negative regulation of cell communication, negative regulation of cell cycle, negative regulation of cell cycle G1/S phase transition, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of cell size, negative regulation of cellular senescence, negative regulation of defense response to bacterium, negative regulation of dendrite extension, negative regulation of dendritic spine morphogenesis, negative regulation of epithelial cell proliferation, negative regulation of epithelial to mesenchymal transition, negative regulation of excitatory postsynaptic potential, negative regulation of focal adhesion assembly, negative regulation of keratinocyte migration, negative regulation of myelination, negative regulation of neuron projection development, negative regulation of organ growth, negative regulation of osteoblast differentiation, negative regulation of phagocytosis, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of ribosome biogenesis, negative regulation of signaling, negative regulation of synaptic vesicle clustering, negative regulation of transport, negative regulation of vascular associated smooth muscle cell proliferation, negative regulation of wound healing, spreading of epidermal cells, nervous system development, neuron projection development, neuron-neuron synaptic transmission, osteoblast differentiation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol dephosphorylation, platelet-derived growth factor receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, positive regulation of cardiac muscle cell apoptotic process, positive regulation of cell population proliferation, positive regulation of excitatory postsynaptic potential, positive regulation of gene expression, positive regulation of interleukin-6 production, positive regulation of intracellular signal transduction, positive regulation of macromolecule metabolic process, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of ubiquitin-dependent protein catabolic process, postsynaptic density assembly, prepulse inhibition, presynaptic membrane assembly, prostate gland growth, protein dephosphorylation, protein stabilization, regulation of B cell apoptotic process, regulation of Fc receptor mediated stimulatory signaling pathway, regulation of axon regeneration, regulation of biological quality, regulation of cell cycle, regulation of cell differentiation, regulation of cellular component size, regulation of cellular localization, regulation of macrophage apoptotic process, regulation of neuron projection development, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of protein stability, regulation of signal transduction, regulation of synaptic transmission, GABAergic, rhythmic synaptic transmission, social behavior, spindle assembly involved in female meiosis, synapse assembly, synapse maturation; MF: PDZ domain binding, anaphase-promoting complex binding, beta-catenin binding, enzyme binding, hydrolase activity, identical protein binding, inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity, ionotropic glutamate receptor binding, molecular function inhibitor activity, phosphatase activity, phosphatidylinositol phosphate phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity, phosphatidylinositol-3-phosphate phosphatase activity, phosphoprotein phosphatase activity, platelet-derived growth factor receptor binding, protein binding, protein kinase binding, protein serine/threonine phosphatase activity, protein tyrosine kinase binding, protein tyrosine phosphatase activity, ubiquitin ligase activator activity, ubiquitin-specific protease binding; CC: PML body, Schmidt-Lanterman incisure, apical plasma membrane, cell projection, cytoplasm, cytoplasmic side of plasma membrane, cytosol, dendritic spine, myelin sheath adaxonal region, neuron projection, nucleoplasm, nucleus, plasma membrane, postsynaptic cytosol, postsynaptic density, postsynaptic membrane, synapse
Pathways: Adaptive Immune System, Autophagy - animal - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Deubiquitination, Diabetic cardiomyopathy - Mus musculus (mouse), Downstream TCR signaling, Endometrial cancer - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Glioma - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Intracellular signaling by second messengers, Melanoma - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of proteins, MicroRNAs in cancer - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Ovarian tumor domain proteases, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI Metabolism, PI3K-Akt signaling pathway - Mus musculus (mouse), PIP metabolism, PIP3 activates AKT signaling, PTEN Regulation, Pathways in cancer - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Post-translational protein modification, Prostate cancer - Mus musculus (mouse), Regulation of PTEN localization, Regulation of PTEN stability and activity, Signal Transduction, Small cell lung cancer - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Synthesis of IP3 and IP4 in the cytosol, Synthesis of PIPs at the plasma membrane, TCR signaling, Ub-specific processing proteases, mTOR signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: O08586
Entrez ID: 19211
|
Does Knockout of Dpys in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Dpys
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dpys (dihydropyrimidinase)
Type: protein-coding
Summary: Enables dihydropyrimidinase activity and phosphoprotein binding activity. Involved in pyrimidine nucleoside monophosphate catabolic process. Is active in cytosol. Is expressed in cranium. Human ortholog(s) of this gene implicated in dihydropyrimidinase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human DPYS (dihydropyrimidinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: CMP catabolic process, UMP catabolic process, beta-alanine metabolic process, dCMP catabolic process, dTMP catabolic process, dUMP catabolic process, pyrimidine nucleobase catabolic process, thymine catabolic process, uracil catabolic process, uracil metabolic process; MF: amino acid binding, dihydropyrimidinase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, identical protein binding, metal ion binding, phosphoprotein binding, thymine binding, uracil binding, zinc ion binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Pyrimidine catabolism, Pyrimidine metabolism - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse), uracil degradation II (reductive)
UniProt: Q9EQF5
Entrez ID: 64705
|
Does Knockout of Abca8a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Abca8a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Abca8a (ATP-binding cassette, sub-family A member 8a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol efflux, cholesterol transport, lipid transport, positive regulation of cholesterol efflux, regulation of cholesterol efflux, sphingomyelin biosynthetic process, transmembrane transport, xenobiotic transport; MF: ABC-type transporter activity, ABC-type xenobiotic transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, lipid transporter activity, nucleotide binding; CC: basolateral plasma membrane, endoplasmic reticulum, intracellular membrane-bounded organelle, membrane, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse)
UniProt: Q8K442
Entrez ID: 217258
|
Does Knockout of Gm12886 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Gm12886
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gm12886 (predicted gene 12886)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: B1AZM5
Entrez ID: 666921
|
Does Knockout of Gramd1a in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Gramd1a
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Gramd1a (GRAM domain containing 1A)
Type: protein-coding
Summary: Enables cholesterol binding activity and cholesterol transfer activity. Involved in cellular response to cholesterol. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Is expressed in central nervous system; liver lobe; skeleton; and vibrissa. Orthologous to human GRAMD1A (GRAM domain containing 1A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: autophagy, cellular response to cholesterol, intracellular sterol transport, lipid transport; MF: cholesterol binding, cholesterol transfer activity, lipid binding; CC: autophagosome, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, membrane, organelle membrane contact site, plasma membrane
Pathways:
UniProt: Q8VEF1
Entrez ID: 52857
|
Does Knockout of Agxt2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Agxt2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Agxt2 (alanine-glyoxylate aminotransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alanine catabolic process, by transamination, N(omega),N(omega)-dimethyl-L-arginine catabolic process, glycine biosynthetic process, by transamination of glyoxylate, glyoxylate catabolic process, positive regulation of nitric oxide biosynthetic process; MF: (R)-3-amino-2-methylpropionate-pyruvate transaminase activity, alanine-glyoxylate transaminase activity, beta-alanine:pyruvate transaminase activity, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: mitochondrion
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Cysteine and methionine metabolism - Mus musculus (mouse), Glycine, serine and threonine metabolism - Mus musculus (mouse), Glyoxylate metabolism and glycine degradation, Metabolism, Metabolism of amino acids and derivatives, Valine, leucine and isoleucine degradation - Mus musculus (mouse), glycine biosynthesis III
UniProt: Q3UEG6
Entrez ID: 268782
|
Does Knockout of Kcnj16 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Kcnj16
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kcnj16 (potassium inwardly-rectifying channel, subfamily J, member 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of monoatomic ion transmembrane transport, regulation of pH, response to carbon dioxide; MF: inward rectifier potassium channel activity; CC: basolateral plasma membrane, membrane, monoatomic ion channel complex, plasma membrane
Pathways: Activation of G protein gated Potassium channels, Activation of GABAB receptors, G protein gated Potassium channels, GABA B receptor activation, GABA receptor activation, Gastric acid secretion - Mus musculus (mouse), Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Inwardly rectifying K+ channels, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Potassium Channels, Potassium transport channels, Transmission across Chemical Synapses
UniProt: Q9Z307
Entrez ID: 16517
|
Does Knockout of Atg4c in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Atg4c
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Atg4c (autophagy related 4C, cysteine peptidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aggrephagy, autophagosome assembly, autophagy, mitophagy, piecemeal microautophagy of the nucleus, protein delipidation, protein processing, protein transport, proteolysis; MF: cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein-phosphatidylethanolamide deconjugating activity; CC: cytoplasm
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Macroautophagy
UniProt: Q811C2
Entrez ID: 242557
|
Does Knockout of Rcor1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,549
|
Knockout
|
Rcor1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rcor1 (REST corepressor 1)
Type: protein-coding
Summary: Enables chromatin binding activity; enzyme binding activity; and transcription corepressor activity. Involved in erythrocyte differentiation; negative regulation of gene expression; and positive regulation of megakaryocyte differentiation. Predicted to be located in nucleoplasm. Predicted to be part of DNA repair complex; histone deacetylase complex; and transcription repressor complex. Is expressed in several structures, including brain; early embryo; extraembryonic component; liver; and nose. Orthologous to human RCOR1 (REST corepressor 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: chromatin organization, erythrocyte differentiation, negative regulation of DNA-templated transcription, negative regulation of gene expression, positive regulation of megakaryocyte differentiation, regulation of transcription by RNA polymerase II; MF: chromatin binding, enzyme binding, protein binding, transcription corepressor activity; CC: DNA repair complex, histone deacetylase complex, histone methyltransferase complex, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Factors involved in megakaryocyte development and platelet production, HDACs deacetylate histones, Hemostasis, Huntington disease - Mus musculus (mouse)
UniProt: Q8CFE3
Entrez ID: 217864
|
Does Knockout of Rfk in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Rfk
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rfk (riboflavin kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: FMN biosynthetic process, apoptotic process, flavin adenine dinucleotide biosynthetic process, reactive oxygen species metabolic process, riboflavin biosynthetic process, riboflavin metabolic process; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, riboflavin kinase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Riboflavin metabolism - Mus musculus (mouse), Vitamin B2 (riboflavin) metabolism, flavin biosynthesis IV (mammalian), riboflavin, FMN and FAD transformations
UniProt: Q8CFV9
Entrez ID: 54391
|
Does Knockout of Pdlim3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Pdlim3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pdlim3 (PDZ and LIM domain 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament organization, heart development, muscle structure development; MF: actin binding, actinin binding, cytoskeletal protein binding, metal ion binding, muscle alpha-actinin binding, protein binding, structural constituent of muscle; CC: Z disc, actin cytoskeleton, adherens junction, cytoplasm, cytosol, filamentous actin, stress fiber
Pathways:
UniProt: O70209
Entrez ID: 53318
|
Does Knockout of 4933405O20Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
4933405O20Rik
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: 4933405O20Rik (RIKEN cDNA 4933405O20 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: isocitrate metabolic process, tricarboxylic acid cycle; MF: ATP binding, magnesium ion binding, metal ion binding, nucleotide binding; CC: mitochondrion
Pathways: Citrate cycle (TCA cycle) - Mus musculus (mouse), TCA cycle variation III (eukaryotic)
UniProt: Q8BPC6
Entrez ID: 243996
|
Does Knockout of Kazn in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Kazn
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kazn (kazrin, periplakin interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: anchoring junction, cornified envelope, cytoplasm, cytoskeleton, cytosol, desmosome, nuclear speck, nucleoplasm, nucleus
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q69ZS8
Entrez ID: 71529
|
Does Knockout of Nup62 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Nup62
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nup62 (nucleoporin 62)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, cell migration, cell surface receptor signaling pathway, cellular senescence, centriole assembly, centrosome cycle, mRNA transport, mitotic centrosome separation, mitotic metaphase chromosome alignment, negative regulation of MAP kinase activity, negative regulation of Ras protein signal transduction, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of programmed cell death, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, positive regulation of canonical NF-kappaB signal transduction, positive regulation of centriole replication, positive regulation of mitotic cytokinetic process, positive regulation of mitotic nuclear division, positive regulation of protein localization to centrosome, protein import into nucleus, protein transport, regulation of mitotic spindle organization, regulation of protein import into nucleus; MF: Hsp70 protein binding, Hsp90 protein binding, PTB domain binding, SH2 domain binding, kinesin binding, nuclear thyroid hormone receptor binding, phospholipid binding, protein binding, protein-containing complex binding, signaling receptor complex adaptor activity, structural constituent of nuclear pore, ubiquitin binding; CC: Flemming body, annulate lamellae, centrosome, cytoplasm, cytoskeleton, mitotic spindle, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore central transport channel, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, spindle pole
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q63850
Entrez ID: 18226
|
Does Knockout of Rnf40 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rnf40
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rnf40 (ring finger protein 40)
Type: protein-coding
Summary: Predicted to enable several functions, including enzyme binding activity; protein homodimerization activity; and syntaxin-1 binding activity. Predicted to be involved in positive regulation of macromolecule metabolic process and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of HULC complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and islets of Langerhans. Orthologous to human RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromatin organization, positive regulation of proteasomal protein catabolic process, positive regulation of protein polyubiquitination, positive regulation of transcription by RNA polymerase II, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: mRNA 3'-UTR binding, metal ion binding, protein binding, protein homodimerization activity, syntaxin-1 binding, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: HULC complex, nucleoplasm, nucleus, protein-containing complex, ubiquitin ligase complex
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination
UniProt: Q3U319
Entrez ID: 233900
|
Does Knockout of Ascc3 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,543
|
Knockout
|
Ascc3
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Ascc3 (activating signal cointegrator 1 complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CAT tailing, DNA alkylation repair, DNA damage response, DNA repair, protein monoubiquitination, protein ufmylation, rescue of stalled ribosome, ribosome disassembly, ribosome-associated ubiquitin-dependent protein catabolic process; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolysis activity, helicase activity, hydrolase activity, isomerase activity, nucleic acid binding, nucleotide binding; CC: DNA repair complex, RQC-trigger complex, cytoplasm, cytosol, cytosolic ribosome, nuclear speck, nucleus
Pathways: Metabolism of proteins, Ribosome-associated quality control, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
UniProt: E9PZJ8
Entrez ID: 77987
|
Does Knockout of Rad50 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Rad50
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rad50 (RAD50 double strand break repair protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA recombination, DNA repair, DNA strand resection involved in replication fork processing, R-loop processing, chromosome organization, chromosome organization involved in meiotic cell cycle, double-strand break repair, double-strand break repair via homologous recombination, homologous recombination, host-mediated suppression of symbiont invasion, meiotic cell cycle, mitotic G2/M transition checkpoint, negative regulation of telomere capping, positive regulation of double-strand break repair, positive regulation of telomere maintenance, regulation of mitotic cell cycle, regulation of mitotic recombination, telomere maintenance, telomere maintenance via recombination, telomere maintenance via telomerase, telomeric 3' overhang formation; MF: 3'-5' exonuclease activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, G-quadruplex DNA binding, double-stranded DNA binding, double-stranded telomeric DNA binding, hydrolase activity, identical protein binding, metal ion binding, nucleotide binding, protein binding, protein serine/threonine kinase activator activity, protein-containing complex binding, protein-macromolecule adaptor activity, single-stranded DNA endodeoxyribonuclease activity, single-stranded telomeric DNA binding; CC: BRCA1-C complex, Mre11 complex, chromatin, chromosomal region, chromosome, chromosome, telomeric region, condensed nuclear chromosome, inclusion body, nucleoplasm, nucleus, perinuclear region of cytoplasm, pronucleus, site of double-strand break
Pathways: Cellular senescence - Mus musculus (mouse), Homologous recombination - Mus musculus (mouse), Non-homologous end-joining - Mus musculus (mouse)
UniProt: E9PUJ2, Q5SV02, A8Y5I3
Entrez ID: 19360
|
Does Knockout of Mybpc3 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Mybpc3
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Mybpc3 (myosin binding protein C, cardiac)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle contraction, cell adhesion, heart morphogenesis, muscle contraction, myosin filament assembly, regulation of heart contraction, regulation of heart rate, sarcomere organization, ventricular cardiac muscle tissue morphogenesis; MF: actin binding, identical protein binding, metal ion binding, myosin binding, myosin heavy chain binding, protein binding, structural constituent of cytoskeleton, structural constituent of muscle; CC: A band, M band, cardiac myofibril, cytoskeleton, myofibril, myosin filament, sarcomere, striated muscle myosin thick filament
Pathways: Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse)
UniProt: Q3UIK0, F6VLV1, Q3TF37, E9Q9T8
Entrez ID: 17868
|
Does Knockout of Vmn1r81 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Vmn1r81
|
response to virus
|
Microglial Cell Line
|
Gene: Vmn1r81 (vomeronasal 1 receptor 81)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R286, A0A2I3BPG7
Entrez ID: 171244
|
Does Knockout of Prrt1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Prrt1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prrt1 (proline-rich transmembrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein localization, learning or memory, long-term synaptic depression, long-term synaptic potentiation, protein localization to cell surface, protein phosphorylation, regulation of AMPA receptor activity, synapse organization; MF: identical protein binding, signaling receptor regulator activity; CC: glutamatergic synapse, membrane, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse, synaptic vesicle membrane
Pathways:
UniProt: O35449
Entrez ID: 260297
|
Does Knockout of Tmem64 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Tmem64
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tmem64 (transmembrane protein 64)
Type: protein-coding
Summary: Involved in negative regulation of canonical Wnt signaling pathway; negative regulation of osteoblast differentiation; and positive regulation of fat cell differentiation. Acts upstream of or within several processes, including positive regulation of bone resorption; positive regulation of osteoclast differentiation; and regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum. Is expressed in several structures, including brain; head mesenchyme; retina nuclear layer; thymus primordium; and vibrissa. Orthologous to human TMEM64 (transmembrane protein 64). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of canonical Wnt signaling pathway, negative regulation of osteoblast differentiation, positive regulation of bone resorption, positive regulation of fat cell differentiation, positive regulation of osteoclast differentiation, regulation of cytosolic calcium ion concentration; CC: endoplasmic reticulum, membrane
Pathways:
UniProt: Q3U145
Entrez ID: 100201
|
Does Knockout of Slc35a2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Slc35a2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc35a2 (solute carrier family 35 (UDP-galactose transporter), member A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: UDP-galactose transmembrane transport, pyrimidine nucleotide-sugar transmembrane transport; MF: UDP-galactose transmembrane transporter activity, antiporter activity, pyrimidine nucleotide-sugar transmembrane transporter activity; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, membrane, nucleoplasm
Pathways: SLC-mediated transmembrane transport, Transport of nucleotide sugars, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q9R0M8
Entrez ID: 22232
|
Does Knockout of Scnm1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Scnm1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Scnm1 (sodium channel modifier 1)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Vmn1r16 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Vmn1r16
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Vmn1r16 (vomeronasal 1 receptor 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BRL5, K7N775
Entrez ID: 171202
|
Does Knockout of Haus2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Haus2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Haus2 (HAUS augmin-like complex, subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome cycle, microtubule nucleation, microtubule organizing center organization, spindle assembly; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, microtubule, mitotic spindle microtubule, spindle, spindle microtubule
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9CQS9
Entrez ID: 66296
|
Does Knockout of B4galnt1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
B4galnt1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: B4galnt1 (beta-1,4-N-acetyl-galactosaminyl transferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate derivative biosynthetic process, determination of adult lifespan, ganglioside biosynthetic process, glycosphingolipid biosynthetic process, glycosphingolipid metabolic process, limb development, lipid metabolic process, lipid storage, motor behavior, nerve development, spermatogenesis, sphingolipid metabolic process, vacuole organization; MF: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity, acetylgalactosaminyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - ganglio series - Mus musculus (mouse), Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Sphingolipid metabolism
UniProt: Q09200
Entrez ID: 14421
|
Does Knockout of Ascl3 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Ascl3
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Ascl3 (achaete-scute family bHLH transcription factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, epithelium development, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, salivary gland development, sensory epithelium regeneration, tissue homeostasis; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity; CC: RNA polymerase II transcription regulator complex, nucleus, transcription regulator complex
Pathways:
UniProt: Q9JJR7
Entrez ID: 56787
|
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