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Does Knockout of Des in Mouse cell causally result in protein/peptide accumulation?
0
1,047
Knockout
Des
protein/peptide accumulation
Mouse cell
Gene: Des (desmin) Type: protein-coding Summary: This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane and are essential for maintaining the stren...
Does Knockout of Taf11 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,271
Knockout
Taf11
cell proliferation
Mouse kidney carcinoma cell
Gene: Taf11 (TATA-box binding protein associated factor 11) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, host-mediated activation of viral transcription, mRNA transcription by RNA polymerase II, positive regulation of t...
Does Knockout of Pold1 in Embryonic Stem Cell Line causally result in cell proliferation?
1
2,477
Knockout
Pold1
cell proliferation
Embryonic Stem Cell Line
Gene: Pold1 (polymerase (DNA directed), delta 1, catalytic subunit) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA replication proofreading, DNA synthesis involved in DNA repair, DNA-template...
Does Knockout of Thoc2 in Embryonic Stem Cell Line causally result in cell proliferation?
1
2,477
Knockout
Thoc2
cell proliferation
Embryonic Stem Cell Line
Gene: Thoc2 (THO complex 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA splicing, blastocyst development, cell morphogenesis, generation of neurons, mRNA export from nucleus, mRNA processing, mRNA transport, negative regulation of neuron projection development, ne...
Does Knockout of Il17rb in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
Il17rb
cell viability
Immortal mouse chromaffin cells
Gene: Il17rb (interleukin 17 receptor B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cytokine-mediated signaling pathway, positive regulation of inflammatory response, positive regulation of interleukin-13 production, positive regulation of interleukin-5 production; M...
Does Knockout of Eln in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Eln
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Eln (elastin) Type: protein-coding Summary: This gene encodes elastin, the extracellular matrix protein that forms a major structural component of several tissues including lungs and arterial walls. Cleavage of the signal peptide from the encoded precursor generates soluble tropoelastin which unde...
Does Knockout of Rdh10 in Embryonic Stem Cell Line causally result in cell proliferation?
0
579
Knockout
Rdh10
cell proliferation
Embryonic Stem Cell Line
Gene: Rdh10 (retinol dehydrogenase 10 (all-trans)) Type: protein-coding Summary: Enables all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic forelimb morphogenesis; and respiratory system development. Located ...
Does Knockout of Hsd3b5 in breast epithelium causally result in cell cycle progression?
0
1,470
Knockout
Hsd3b5
cell cycle progression
breast epithelium
Gene: Hsd3b5 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: C21-steroid hormone metabolic process, lipid metabolic process, response to stilbenoid, steroid biosynthetic process, steroid metabo...
Does Knockout of Pold3 in Microglial Cell Line causally result in response to virus?
1
1,438
Knockout
Pold3
response to virus
Microglial Cell Line
Gene: Pold3 (polymerase (DNA-directed), delta 3, accessory subunit) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA synthesis involved in UV-...
Does Knockout of Cyp2f2 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,264
Knockout
Cyp2f2
cell proliferation
Colonic Cancer Cell Line
Gene: Cyp2f2 (cytochrome P450, family 2, subfamily f, polypeptide 2) Type: protein-coding Summary: Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or fl...
Does Knockout of Tbc1d21 in Microglial Cell Line causally result in response to virus?
0
2,429
Knockout
Tbc1d21
response to virus
Microglial Cell Line
Gene: Tbc1d21 (TBC1 domain family, member 21) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, flagellated sperm motility, plasma membrane to endosome transport, sperm axoneme assembly, sperm mitochondrial sheath assembly, spermatogenesis; MF: GTPase ...
Does Knockout of Eloa in myoblast cell line causally result in protein/peptide distribution?
0
1,681
Knockout
Eloa
protein/peptide distribution
myoblast cell line
Gene: Eloa (elongin A) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation ...
Does Knockout of Kdm4a in Mouse kidney carcinoma cell causally result in cell proliferation?
1
1,271
Knockout
Kdm4a
cell proliferation
Mouse kidney carcinoma cell
Gene: Kdm4a (lysine (K)-specific demethylase 4A) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic chromosome condensation, cardiac muscle hypertrophy in response to stress, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcr...
Does Knockout of Vmn1r215 in Microglial Cell Line causally result in protein/peptide distribution?
0
1,585
Knockout
Vmn1r215
protein/peptide distribution
Microglial Cell Line
Gene: Vmn1r215 (vomeronasal 1 receptor 215) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromon...
Does Knockout of Ing5 in Mouse kidney carcinoma cell causally result in cell proliferation?
1
1,290
Knockout
Ing5
cell proliferation
Mouse kidney carcinoma cell
Gene: Ing5 (inhibitor of growth family, member 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA replication-dependent chromatin disassembly, chromatin organization, negative regulation of cell population proliferation, negative regulation of fibroblast proliferation...
Does Knockout of Klf17 in Embryonic Stem Cell Line causally result in cell proliferation?
0
578
Knockout
Klf17
cell proliferation
Embryonic Stem Cell Line
Gene: Klf17 (Kruppel-like transcription factor 17) Type: protein-coding Summary: No summary available. Gene Ontology: BP: gamete generation, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription fa...
Does Knockout of Rgs10 in myoblast cell line causally result in protein/peptide distribution?
0
1,682
Knockout
Rgs10
protein/peptide distribution
myoblast cell line
Gene: Rgs10 (regulator of G-protein signalling 10) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled acetylcholine receptor signaling pathway, negative regulation of signal transduction, positive regulation of GTPase activity, regulation of G protein-coupl...
Does Knockout of Galnt7 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
688
Knockout
Galnt7
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Galnt7 (polypeptide N-acetylgalactosaminyltransferase 7) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein O-linked glycosylation, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, polypeptide N-acetylgalactosami...
Does Knockout of Bex3 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Bex3
phagocytosis
macrophage
Gene: Bex3 (brain expressed X-linked 3) Type: protein-coding Summary: Enables death receptor binding activity and molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors....
Does Knockout of Crebzf in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
82
Knockout
Crebzf
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Crebzf (CREB/ATF bZIP transcription factor) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of gene expression, epigenetic, positive regulation of transcription by RNA polymerase II, regulation ...
Does Knockout of Efnb3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Efnb3
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Efnb3 (ephrin B3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: T cell costimulation, adult walking behavior, axon choice point recognition, axon guidance, cell differentiation, cell-cell signaling, ephrin receptor signaling pathway, negative regulation of axonoge...
Does Knockout of Timeless in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Timeless
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Timeless (timeless circadian clock 1) Type: protein-coding Summary: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The enco...
Does Knockout of Mrpl55 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
1
684
Knockout
Mrpl55
cell proliferation
Acute Myeloid Leukemia Cell Line
Gene: Mrpl55 (mitochondrial ribosomal protein L55) Type: protein-coding Summary: No summary available. Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribon...
Does Knockout of Psg16 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,262
Knockout
Psg16
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Psg16 (pregnancy specific beta-1-glycoprotein 16) Type: protein-coding Summary: No summary available. Gene Ontology: BP: T cell activation, immune response; CC: cell surface, external side of plasma membrane Pathways: UniProt: D0VY58, Q8K0U8, Q60962, D3YXQ6 Entr...
Does Knockout of Acot7 in myoblast cell line causally result in protein/peptide distribution?
1
1,679
Knockout
Acot7
protein/peptide distribution
myoblast cell line
Gene: Acot7 (acyl-CoA thioesterase 7) Type: protein-coding Summary: No summary available. Gene Ontology: BP: acyl-CoA metabolic process, coenzyme A biosynthetic process, fatty acid catabolic process, fatty acid metabolic process, lipid metabolic process, long-chain fatty-acyl-CoA catabolic proc...
Does Knockout of Ptrhd1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,273
Knockout
Ptrhd1
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Ptrhd1 (peptidyl-tRNA hydrolase domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: MF: hydrolase activity, molecular_function, peptidyl-tRNA hydrolase activity Pathways: UniProt: D3Z4S3 Entrez ID: 69709
Does Knockout of Nsun5 in Embryonic Stem Cell Line causally result in cell proliferation?
1
2,477
Knockout
Nsun5
cell proliferation
Embryonic Stem Cell Line
Gene: Nsun5 (NOL1/NOP2/Sun domain family, member 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA methylation, cerebral cortex development, cognition, corpus callosum development, methylation, oligodendrocyte development, positive regulation of translation, rRNA bas...
Does Knockout of Vmn1r158 in myoblast cell line causally result in protein/peptide distribution?
0
1,681
Knockout
Vmn1r158
protein/peptide distribution
myoblast cell line
Gene: Vmn1r158 (vomeronasal 1 receptor 158) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled recepto...
Does Knockout of Rsl24d1 in Embryonic Fibroblast Cell Line causally result in response to virus?
0
1,133
Knockout
Rsl24d1
response to virus
Embryonic Fibroblast Cell Line
Gene: Rsl24d1 (ribosomal L24 domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome biogenesis; CC: nucleolus, nucleoplasm, nucleus Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Ribosom...
Does Knockout of Rnd3 in myoblast cell line causally result in protein/peptide distribution?
0
1,679
Knockout
Rnd3
protein/peptide distribution
myoblast cell line
Gene: Rnd3 (Rho family GTPase 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: actin filament organization, regulation of actin cytoskeleton organization, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide bindin...
Does Knockout of Nrde2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
1
2,307
Knockout
Nrde2
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Nrde2 (nrde-2 necessary for RNA interference, domain containing) Type: protein-coding Summary: Predicted to be involved in several processes, including RNA splicing; negative regulation of macromolecule metabolic process; and positive regulation of RNA export from nucleus. Predicted to be located ...
Does Knockout of Tgm2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,287
Knockout
Tgm2
cell proliferation
Mouse kidney carcinoma cell
Gene: Tgm2 (transglutaminase 2, C polypeptide) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, apoptotic cell clearance, blood vessel remodeling, bone development, branching involved in salivary gland morphogenesis, cellular r...
Does Knockout of Paox in Melanoma Cell Line causally result in cell proliferation?
1
1,157
Knockout
Paox
cell proliferation
Melanoma Cell Line
Gene: Paox (polyamine oxidase (exo-N4-amino)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: polyamine catabolic process, positive regulation of spermidine biosynthetic process, putrescine biosynthetic process, putrescine catabolic process, spermidine catabolic process, ...
Does Knockout of Psen1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,262
Knockout
Psen1
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Psen1 (presenilin 1) Type: protein-coding Summary: Enables aspartic-type endopeptidase activity and cadherin binding activity. Contributes to aspartic endopeptidase activity, intramembrane cleaving. Involved in several processes, including protein catabolic process at postsynapse; regulation of ma...
Does Knockout of Drc7 in Microglial Cell Line causally result in protein/peptide distribution?
0
1,585
Knockout
Drc7
protein/peptide distribution
Microglial Cell Line
Gene: Drc7 (dynein regulatory complex subunit 7) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, flagellated sperm motility, sperm axoneme assembly, spermatogenesis; CC: cell projection, cilium, cytoplasm, cytoskeleton, motile cilium Pathway...
Does Knockout of Cbfb in Colonic Cancer Cell Line causally result in cell proliferation?
1
1,275
Knockout
Cbfb
cell proliferation
Colonic Cancer Cell Line
Gene: Cbfb (core binding factor beta) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell maturation, definitive hemopoiesis, lymphocyte differentiation, myeloid cell differentiation, negative regulation of CD4-positive, alpha-beta T cell differentiation, negative regula...
Does Knockout of Esco2 in Lymphoma Cell Line causally result in response to chemicals?
1
1,553
Knockout
Esco2
response to chemicals
Lymphoma Cell Line
Gene: Esco2 (establishment of sister chromatid cohesion N-acetyltransferase 2) Type: protein-coding Summary: Enables L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Acts upstream of or within several processes, including double-strand break repair; hematopoietic progenitor ce...
Does Knockout of Bcan in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
Bcan
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Bcan (brevican) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell adhesion, cell-matrix adhesion, central nervous system development, hippocampus development, neuron projection extension, skeletal system development, synapse maturation; MF: calcium ion binding, c...
Does Knockout of Hoxd10 in myoblast cell line causally result in protein/peptide distribution?
1
1,681
Knockout
Hoxd10
protein/peptide distribution
myoblast cell line
Gene: Hoxd10 (homeobox D10) Type: protein-coding Summary: No summary available. Gene Ontology: BP: adult locomotory behavior, anterior/posterior pattern specification, embryonic limb morphogenesis, embryonic skeletal system morphogenesis, forelimb morphogenesis, hindlimb morphogenesis, neuromus...
Does Knockout of Tdrd1 in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
Tdrd1
cell viability
Immortal mouse chromaffin cells
Gene: Tdrd1 (tudor domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: P granule organization, cell differentiation, germ cell development, meiotic cell cycle, piRNA processing, regulatory ncRNA-mediated gene silencing, spermatogenesis, transposable eleme...
Does Knockout of Angptl2 in myoblast cell line causally result in protein/peptide distribution?
1
1,684
Knockout
Angptl2
protein/peptide distribution
myoblast cell line
Gene: Angptl2 (angiopoietin-like 2) Type: protein-coding Summary: No summary available. Gene Ontology: CC: extracellular matrix, extracellular region, extracellular space Pathways: UniProt: Q9R045 Entrez ID: 26360
Does Knockout of Kdm8 in Mouse kidney carcinoma cell causally result in cell proliferation?
1
1,288
Knockout
Kdm8
cell proliferation
Mouse kidney carcinoma cell
Gene: Kdm8 (lysine (K)-specific demethylase 8) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G2/M transition of mitotic cell cycle, chromatin organization, chromatin remodeling, circadian regulation of gene expression, fibroblast proliferation, in utero embryonic develo...
Does Knockout of Gtsf1l in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
161
Knockout
Gtsf1l
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Gtsf1l (gametocyte specific factor 1-like) Type: protein-coding Summary: No summary available. Gene Ontology: MF: metal ion binding, molecular_function, protein-containing complex binding, zinc ion binding Pathways: UniProt: Q9CWD0 Entrez ID: 68236
Does Knockout of Tas2r125 in myoblast cell line causally result in protein/peptide distribution?
0
1,679
Knockout
Tas2r125
protein/peptide distribution
myoblast cell line
Gene: Tas2r125 (taste receptor, type 2, member 125) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sens...
Does Knockout of Tspan7 in breast epithelium causally result in cell cycle progression?
0
1,468
Knockout
Tspan7
cell cycle progression
breast epithelium
Gene: Tspan7 (tetraspanin 7) Type: protein-coding Summary: No summary available. Gene Ontology: CC: membrane, plasma membrane, postsynapse Pathways: Glutamate binding, activation of AMPA receptors and synaptic plasticity, Neuronal System, Neurotransmitter receptors and postsynaptic sig...
Does Knockout of Fry in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
161
Knockout
Fry
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Fry (FRY microtubule binding protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell morphogenesis, negative regulation of tubulin deacetylation, neuron projection development; CC: cell cortex, centrosome, cytoplasm, cytoskeleton, site of polarized growth, spi...
Does Knockout of Hspe1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Hspe1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Hspe1 (heat shock protein 1 (chaperonin 10)) Type: protein-coding Summary: Predicted to enable metal ion binding activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Located in mitoc...
Does Knockout of Clstn1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
165
Knockout
Clstn1
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Clstn1 (calsyntenin 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell adhesion, chemical synaptic transmission, homophilic cell adhesion via plasma membrane adhesion molecules, intracellular calcium ion homeostasis, neurotransmitter receptor transport to posts...
Does Knockout of Ankrd39 in myoblast cell line causally result in protein/peptide distribution?
1
1,684
Knockout
Ankrd39
protein/peptide distribution
myoblast cell line
Gene: Ankrd39 (ankyrin repeat domain 39) Type: protein-coding Summary: Is expressed in dorsal root ganglion and ventral grey horn. Orthologous to human ANKRD39 (ankyrin repeat domain 39). [provided by Alliance of Genome Resources, Jul 2025] Gene Ontology: Pathways: UniProt: ...
Does Knockout of Clec4a4 in Immortal mouse chromaffin cells causally result in cell viability?
1
2,469
Knockout
Clec4a4
cell viability
Immortal mouse chromaffin cells
Gene: Clec4a4 (C-type lectin domain family 4, member a4) Type: protein-coding Summary: Enables carbohydrate derivative binding activity. Predicted to be involved in several processes, including antifungal innate immune response; negative regulation of tumor necrosis factor production; and plasmacytoid d...
Does Knockout of Mlc1 in Melanoma Cell Line causally result in cell proliferation?
0
2,492
Knockout
Mlc1
cell proliferation
Melanoma Cell Line
Gene: Mlc1 (megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: caveolin-mediated endocytosis, cellular response to cholesterol, monoatomic ion transmembrane transport, positive regulation of intrac...
Does Knockout of Ptpru in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
1,130
Knockout
Ptpru
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Ptpru (protein tyrosine phosphatase receptor type U) Type: protein-coding Summary: No summary available. Gene Ontology: BP: animal organ regeneration, cell adhesion, cell differentiation, homotypic cell-cell adhesion, negative regulation of canonical Wnt signaling pathway, negative regula...
Does Knockout of Plpp5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
Plpp5
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Plpp5 (phospholipid phosphatase 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: lipid metabolic process, phospholipid dephosphorylation, phospholipid metabolic process; MF: diacylglycerol diphosphate phosphatase activity, hydrolase activity, phosphatidate phospha...
Does Knockout of Enpp3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
161
Knockout
Enpp3
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Enpp3 (ectonucleotide pyrophosphatase/phosphodiesterase 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ATP metabolic process, basophil activation involved in immune response, negative regulation of cGAS/STING signaling pathway, negative regulation of inflammator...
Does Knockout of Plekhg1 in myoblast cell line causally result in protein/peptide distribution?
1
1,679
Knockout
Plekhg1
protein/peptide distribution
myoblast cell line
Gene: Plekhg1 (pleckstrin homology domain containing, family G (with RhoGef domain) member 1) Type: protein-coding Summary: No summary available. Gene Ontology: MF: guanyl-nucleotide exchange factor activity, small GTPase binding; CC: cytosol, nucleoplasm Pathways: UniProt: Q...
Does Knockout of Nup43 in Embryonic Stem Cell Line causally result in cell proliferation?
0
579
Knockout
Nup43
cell proliferation
Embryonic Stem Cell Line
Gene: Nup43 (nucleoporin 43) Type: protein-coding Summary: Predicted to be involved in nucleocytoplasmic transport. Predicted to be located in cytosol; nuclear envelope; and nuclear speck. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Is expressed in several ...
Does Knockout of Bean1 in myoblast cell line causally result in protein/peptide distribution?
0
1,681
Knockout
Bean1
protein/peptide distribution
myoblast cell line
Gene: Bean1 (brain expressed, associated with Nedd4, 1) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cellular_component, membrane Pathways: Spinocerebellar ataxia - Mus musculus (mouse) UniProt: Q9EQG5 Entrez ID: 65115
Does Knockout of Smarcb1 in Melanoma Cell Line causally result in cell proliferation?
0
2,492
Knockout
Smarcb1
cell proliferation
Melanoma Cell Line
Gene: Smarcb1 (SWI/SNF related BAF chromatin remodeling complex subunit B1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, blastocyst development, blastocyst hatching, chromatin organization, chromatin remodeling, hepatocy...
Does Knockout of Bdp1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
1
1,273
Knockout
Bdp1
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Bdp1 (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA polymerase III preinitiation complex assembly, regulation of DNA-templated transcription; CC: nucleoplasm, nucleus, transc...
Does Knockout of Nup214 in Melanoma Cell Line causally result in cell proliferation?
1
1,270
Knockout
Nup214
cell proliferation
Melanoma Cell Line
Gene: Nup214 (nucleoporin 214) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA export from nucleus, intracellular protein transport, mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein export from nucleus, protein import into nucleus, protei...
Does Knockout of Snx7 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Snx7
protein/peptide accumulation
Embryonic Cell Line
Gene: Snx7 (sorting nexin 7) Type: protein-coding Summary: No summary available. Gene Ontology: BP: endocytic recycling, mitophagy, piecemeal microautophagy of the nucleus, positive regulation of autophagosome assembly, protein transport, reticulophagy; MF: lipid binding, phosphatidylinositol b...
Does Knockout of Mrpl45 in Colonic Cancer Cell Line causally result in cell proliferation?
1
1,275
Knockout
Mrpl45
cell proliferation
Colonic Cancer Cell Line
Gene: Mrpl45 (mitochondrial ribosomal protein L45) Type: protein-coding Summary: No summary available. Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein ...
Does Knockout of Snrpd3 in Melanoma Cell Line causally result in cell proliferation?
1
1,270
Knockout
Snrpd3
cell proliferation
Melanoma Cell Line
Gene: Snrpd3 (small nuclear ribonucleoprotein D3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal snRNP assembly; MF: RNA binding, U1 snRNP binding, U7 snRNA binding, enzyme bindin...
Does Knockout of Pcdhb22 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,275
Knockout
Pcdhb22
cell proliferation
Colonic Cancer Cell Line
Gene: Pcdhb22 (protocadherin beta 22) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, photoreceptor connecting cilium, pl...
Does Knockout of Nup50 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
687
Knockout
Nup50
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Nup50 (nucleoporin 50) Type: protein-coding Summary: No summary available. Gene Ontology: BP: mRNA transport, neural tube formation, nucleocytoplasmic transport, protein import into nucleus, protein transport; CC: membrane, nuclear envelope, nuclear membrane, nuclear pore, nucleoplasm, nu...
Does Knockout of Zfp319 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,289
Knockout
Zfp319
cell proliferation
Mouse kidney carcinoma cell
Gene: Zfp319 (zinc finger protein 319) Type: protein-coding Summary: No summary available. Gene Ontology: MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus Pathways: UniProt: Q9ERR8 Entrez ID: 79233
Does Knockout of Cdv3 in Embryonic Fibroblast Cell Line causally result in response to virus?
0
1,133
Knockout
Cdv3
response to virus
Embryonic Fibroblast Cell Line
Gene: Cdv3 (carnitine deficiency-associated gene expressed in ventricle 3) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cytoplasm, cytosol, plasma membrane Pathways: UniProt: Q4VAA2 Entrez ID: 321022
Does Knockout of Ints3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
161
Knockout
Ints3
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Ints3 (integrator complex subunit 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II transcription initiation surveillance, double-strand break repair via homologous recombination, mitotic G2/M transition checkpoint...
Does Knockout of Gpr85 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
161
Knockout
Gpr85
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Gpr85 (G protein-coupled receptor 85) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: endoplasmic reticulum, membrane, plasma membrane Pathways: ...
Does Knockout of Krt13 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
161
Knockout
Krt13
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Krt13 (keratin 13) Type: protein-coding Summary: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the...
Does Knockout of Ctu2 in Embryonic Stem Cell Line causally result in cell proliferation?
1
2,477
Knockout
Ctu2
cell proliferation
Embryonic Stem Cell Line
Gene: Ctu2 (cytosolic thiouridylase subunit 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification; MF: nucleotidyltransferase activity, sulf...
Does Knockout of Lig4 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
1
684
Knockout
Lig4
cell proliferation
Acute Myeloid Leukemia Cell Line
Gene: Lig4 (ligase IV, DNA, ATP-dependent) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DN2 thymocyte differentiation, DNA biosynthetic process, DNA damage response, DNA recombination, DNA repair, T cell receptor V(D)J recombination, V(D)J recombination, base-excision ...
Does Knockout of Cdh5 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,288
Knockout
Cdh5
cell proliferation
Mouse kidney carcinoma cell
Gene: Cdh5 (cadherin 5) Type: protein-coding Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mi...
Does Knockout of Hes6 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Hes6
phagocytosis
macrophage
Gene: Hes6 (hairy and enhancer of split 6) Type: protein-coding Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and transcription regulator in...
Does Knockout of Spcs3 in macrophage causally result in phagocytosis?
1
1,888
Knockout
Spcs3
phagocytosis
macrophage
Gene: Spcs3 (signal peptidase complex subunit 3 homolog (S. cerevisiae)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein targeting to ER, proteolysis, signal peptide processing, viral protein processing; CC: endoplasmic reticulum, endoplasmic reticulum membrane, m...
Does Knockout of Mrpl41 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
1
684
Knockout
Mrpl41
cell proliferation
Acute Myeloid Leukemia Cell Line
Gene: Mrpl41 (mitochondrial ribosomal protein L41) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic process, mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, m...
Does Knockout of Umps in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Umps
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Umps (uridine monophosphate synthetase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: 'de novo' UMP biosynthetic process, 'de novo' pyrimidine nucleobase biosynthetic process, UDP biosynthetic process, UMP biosynthetic process, pyrimidine nucleobase biosynthetic p...
Does Knockout of Wdr77 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,152
Knockout
Wdr77
protein/peptide accumulation
Embryonic Cell Line
Gene: Wdr77 (WD repeat domain 77) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation involved in prostate gland development, oocyte axis specification, positive regulat...
Does Knockout of Itgam in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,172
Knockout
Itgam
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Itgam (integrin alpha M) Type: protein-coding Summary: Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development...
Does Knockout of Fdft1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Fdft1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Fdft1 (farnesyl diphosphate farnesyl transferase 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, f...
Does Knockout of Ppcdc in myoblast cell line causally result in protein/peptide distribution?
1
1,682
Knockout
Ppcdc
protein/peptide distribution
myoblast cell line
Gene: Ppcdc (phosphopantothenoylcysteine decarboxylase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: coenzyme A biosynthetic process; MF: FMN binding, carboxy-lyase activity, catalytic activity, identical protein binding, lyase activity, phosphopantothenoylcysteine dec...
Does Knockout of Hmga2 in Lymphoma Cell Line causally result in response to chemicals?
0
1,545
Knockout
Hmga2
response to chemicals
Lymphoma Cell Line
Gene: Hmga2 (high mobility group AT-hook 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: adipose tissue development, adrenal gland development, base-excision repair, cell division, cell proliferation in forebrain, chondrocyte differentiation, chondrocyte proliferation,...
Does Knockout of Cenpw in macrophage causally result in phagocytosis?
0
1,888
Knockout
Cenpw
phagocytosis
macrophage
Gene: Cenpw (centromere protein W) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell division, chromosome organization, chromosome segregation, kinetochore assembly, mitotic cell cycle; MF: DNA binding, molecular_function, protein heterodimerization activity; CC: chrom...
Does Knockout of Bcas3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
165
Knockout
Bcas3
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Bcas3 (BCAS3 microtubule associated cell migration factor) Type: protein-coding Summary: No summary available. Gene Ontology: BP: angiogenesis, autophagy, cell-cell signaling, cellular response to estrogen stimulus, positive regulation of catalytic activity, positive regulation of endothe...
Does Knockout of Polk in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
Polk
cell viability
Immortal mouse chromaffin cells
Gene: Polk (polymerase (DNA directed), kappa) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, cellular response to UV, error-prone translesion synthesis, nucleotide-excision repair, DNA gap fillin...
Does Knockout of Morf4l2 in Embryonic Fibroblast Cell Line causally result in response to virus?
1
1,133
Knockout
Morf4l2
response to virus
Embryonic Fibroblast Cell Line
Gene: Morf4l2 (mortality factor 4 like 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombin...
Does Knockout of Sema4c in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,267
Knockout
Sema4c
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Sema4c (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C) Type: protein-coding Summary: This gene encodes a member of the semaphorin family of proteins that have diverse functions in neuronal development, heart morphogenesis, vascular...
Does Knockout of Il5 in Microglial Cell Line causally result in protein/peptide distribution?
0
1,585
Knockout
Il5
protein/peptide distribution
Microglial Cell Line
Gene: Il5 (interleukin 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cytokine-mediated signaling pathway, eosinophil differentiation, immune response, interleukin-5-mediated signaling pathway, positive regulation of B cell proliferation, positive regulation of cell p...
Does Knockout of Slc3a2 in Embryonic Stem Cell Line causally result in cell proliferation?
1
2,477
Knockout
Slc3a2
cell proliferation
Embryonic Stem Cell Line
Gene: Slc3a2 (solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: L-alanine import across plasma membrane, L-histidine transport, L-leucine import across plasma membrane, L-leucine tra...
Does Knockout of Gramd4 in Embryonic Cell Line causally result in protein/peptide accumulation?
1
1,152
Knockout
Gramd4
protein/peptide accumulation
Embryonic Cell Line
Gene: Gramd4 (GRAM domain containing 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic process, negative regulation of toll-like receptor 9 signaling pathway, positive regulation of apoptotic process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, m...
Does Knockout of Cyp7b1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
165
Knockout
Cyp7b1
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Cyp7b1 (cytochrome P450, family 7, subfamily b, polypeptide 1) Type: protein-coding Summary: Predicted to enable oxysterol 7-alpha-hydroxylase activity. Involved in B cell chemotaxis and bile acid biosynthetic process. Acts upstream of or within negative regulation of intracellular estrogen recept...
Does Knockout of Bdkrb1 in Embryonic Stem Cell Line causally result in cell proliferation?
1
2,477
Knockout
Bdkrb1
cell proliferation
Embryonic Stem Cell Line
Gene: Bdkrb1 (bradykinin receptor, beta 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell migration, inflammatory response, negative regulation of blood pressure, negative regulation of cell growth, positive regulation o...
Does Knockout of Dusp18 in myoblast cell line causally result in protein/peptide distribution?
1
1,684
Knockout
Dusp18
protein/peptide distribution
myoblast cell line
Gene: Dusp18 (dual specificity phosphatase 18) Type: protein-coding Summary: No summary available. Gene Ontology: BP: dephosphorylation, peptidyl-threonine dephosphorylation, peptidyl-tyrosine dephosphorylation, protein targeting to membrane, protein targeting to mitochondrion, response to anti...
Does Knockout of Rpl29 in Lymphoma Cell Line causally result in response to chemicals?
0
1,536
Knockout
Rpl29
response to chemicals
Lymphoma Cell Line
Gene: Rpl29 (ribosomal protein L29) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell-substrate adhesion, cytoplasmic translation, fibroblast proliferation, multicellular organism growth, translation, translation at postsynapse, translation at presynapse; MF: heparin b...
Does Knockout of Cyp2c68 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
1,130
Knockout
Cyp2c68
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Cyp2c68 (cytochrome P450, family 2, subfamily c, polypeptide 68) Type: protein-coding Summary: No summary available. Gene Ontology: BP: epoxygenase P450 pathway, estrogen metabolic process, icosanoid biosynthetic process, lipid hydroxylation, organic acid metabolic process, oxidative deme...
Does Knockout of Dclre1b in Lymphoma Cell Line causally result in response to chemicals?
0
1,523
Knockout
Dclre1b
response to chemicals
Lymphoma Cell Line
Gene: Dclre1b (DNA cross-link repair 1B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via nonhomologous end joining, interstrand cross-link repair, nucleotide-excision repair, protection from non-homologous en...
Does Knockout of Tmem248 in Melanoma Cell Line causally result in cell proliferation?
1
1,270
Knockout
Tmem248
cell proliferation
Melanoma Cell Line
Gene: Tmem248 (transmembrane protein 248) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cellular_component, membrane Pathways: UniProt: Q3TBN1 Entrez ID: 71667
Does Knockout of Epg5 in myoblast cell line causally result in protein/peptide distribution?
1
1,682
Knockout
Epg5
protein/peptide distribution
myoblast cell line
Gene: Epg5 (ectopic P-granules 5 autophagy tethering factor) Type: protein-coding Summary: No summary available. Gene Ontology: BP: anatomical structure homeostasis, apoptotic process, autophagosome maturation, autophagy, cellular response to dsDNA, defense response to virus, endocytic recyclin...
Does Knockout of Usp18 in Melanoma Cell Line causally result in cell proliferation?
1
1,158
Knockout
Usp18
cell proliferation
Melanoma Cell Line
Gene: Usp18 (ubiquitin specific peptidase 18) Type: protein-coding Summary: No summary available. Gene Ontology: BP: antiviral innate immune response, negative regulation of type I interferon-mediated signaling pathway, protein deubiquitination, proteolysis, regulation of inflammatory response,...
Does Knockout of Fam107b in macrophage causally result in phagocytosis?
0
1,888
Knockout
Fam107b
phagocytosis
macrophage
Gene: Fam107b (family with sequence similarity 107, member B) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q3TGF2 Entrez ID: 66540