prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Des in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Des
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Des (desmin)
Type: protein-coding
Summary: This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane and are essential for maintaining the strength and integrity of skeletal, cardiac and smooth muscle fibers. Mutations in this gene affect assembly of intermediate filaments. Mice lacking this gene are able to develop and reproduce but exhibit abnormal muscle fibers. Mutations in the human gene are associated with myofibrillar myopathy, dilated cardiomyopathy, neurogenic scapuloperoneal syndrome and autosomal recessive limb-girdle muscular dystrophy, type 2R. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: cytoskeleton organization, intermediate filament organization, muscle organ development, nuclear envelope organization, skeletal muscle organ development; MF: cytoskeletal protein binding, identical protein binding, protein binding, structural constituent of cytoskeleton; CC: Z disc, cardiac myofibril, cell tip, cell-cell junction, contractile muscle fiber, cytoplasm, cytoskeleton, fascia adherens, gap junction, intercalated disc, intermediate filament, intermediate filament cytoskeleton, membrane, neuromuscular junction, nuclear envelope, nucleus, plasma membrane, sarcolemma, supramolecular fiber, type III intermediate filament
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Muscle contraction, Striated Muscle Contraction
UniProt: P31001
Entrez ID: 13346
|
Does Knockout of Taf11 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Taf11
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Taf11 (TATA-box binding protein associated factor 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, host-mediated activation of viral transcription, mRNA transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, protein binding, protein heterodimerization activity, transcription coactivator activity; CC: Golgi apparatus, nucleoplasm, nucleus, transcription factor TFIID complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q99JX1
Entrez ID: 68776
|
Does Knockout of Pold1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Pold1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pold1 (polymerase (DNA directed), delta 1, catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA replication proofreading, DNA synthesis involved in DNA repair, DNA-templated DNA replication, base-excision repair, gap-filling, cellular response to UV, error-free translesion synthesis, fatty acid homeostasis, nucleotide-excision repair, DNA gap filling; MF: 3'-5' exonuclease activity, 3'-5'-DNA exonuclease activity, 4 iron, 4 sulfur cluster binding, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, catalytic activity, acting on a nucleic acid, chromatin binding, damaged DNA binding, enzyme binding, exonuclease activity, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, transferase activity, zinc ion binding; CC: aggresome, chromosome, telomeric region, cytosol, delta DNA polymerase complex, nucleoplasm, nucleotide-excision repair complex, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P52431
Entrez ID: 18971
|
Does Knockout of Thoc2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Thoc2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Thoc2 (THO complex 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, blastocyst development, cell morphogenesis, generation of neurons, mRNA export from nucleus, mRNA processing, mRNA transport, negative regulation of neuron projection development, neuron development, poly(A)+ mRNA export from nucleus, regulation of gene expression, regulation of mRNA export from nucleus, stem cell division; MF: RNA binding, mRNA binding, protein binding; CC: THO complex, THO complex part of transcription export complex, chromosome, telomeric region, cytoplasm, nuclear speck, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: B1AZI6
Entrez ID: 331401
|
Does Knockout of Il17rb in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Il17rb
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Il17rb (interleukin 17 receptor B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, positive regulation of inflammatory response, positive regulation of interleukin-13 production, positive regulation of interleukin-5 production; MF: cytokine receptor activity, interleukin-17 receptor activity, protein binding; CC: cell surface, cytoplasm, extracellular region, membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse)
UniProt: Q9JIP3
Entrez ID: 50905
|
Does Knockout of Eln in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Eln
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eln (elastin)
Type: protein-coding
Summary: This gene encodes elastin, the extracellular matrix protein that forms a major structural component of several tissues including lungs and arterial walls. Cleavage of the signal peptide from the encoded precursor generates soluble tropoelastin which undergoes lysine-derived crosslinking to form elastin polymers. Mice lacking the encoded protein exhibit defective lung development, and die of an obstructive arterial disease resulting from subendothelial cell proliferation and reorganization of smooth muscle. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: aortic valve morphogenesis, blood vessel remodeling, extracellular matrix assembly, extracellular matrix organization, outflow tract morphogenesis, regulation of actin filament polymerization, skeletal muscle tissue development, stress fiber assembly; MF: extracellular matrix binding, extracellular matrix constituent conferring elasticity, extracellular matrix structural constituent, protein binding; CC: elastic fiber, extracellular matrix, extracellular region, extracellular space, mitochondrion
Pathways: Degradation of the extracellular matrix, Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres, Protein digestion and absorption - Mus musculus (mouse)
UniProt: P54320
Entrez ID: 13717
|
Does Knockout of Rdh10 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Rdh10
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rdh10 (retinol dehydrogenase 10 (all-trans))
Type: protein-coding
Summary: Enables all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic forelimb morphogenesis; and respiratory system development. Located in membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: animal organ morphogenesis, bud elongation involved in lung branching, ear development, embryonic camera-type eye development, embryonic forelimb morphogenesis, embryonic organ development, embryonic viscerocranium morphogenesis, gonad development, in utero embryonic development, lipid metabolic process, metanephros development, neural crest cell development, nose development, positive regulation of retinoic acid biosynthetic process, primary lung bud formation, regulation of hormone levels, retinal metabolic process, retinoic acid biosynthetic process, retinol metabolic process, visual perception; MF: all-trans-retinol dehydrogenase (NAD+) activity, all-trans-retinol dehydrogenase (NADP+) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane
Pathways: RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, The canonical retinoid cycle in rods (twilight vision), Visual phototransduction
UniProt: Q8VCH7
Entrez ID: 98711
|
Does Knockout of Hsd3b5 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Hsd3b5
|
cell cycle progression
|
breast epithelium
|
Gene: Hsd3b5 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: C21-steroid hormone metabolic process, lipid metabolic process, response to stilbenoid, steroid biosynthetic process, steroid metabolic process; MF: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity, 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity, 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, steroid Delta-isomerase activity, steroid binding; CC: cilium, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intercellular bridge, intracellular membrane-bounded organelle, membrane, microtubule cytoskeleton, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion, nucleolus
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Androgen biosynthesis, Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Glucocorticoid biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Mineralocorticoid biosynthesis, Ovarian steroidogenesis - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse)
UniProt: Q61694
Entrez ID: 15496
|
Does Knockout of Pold3 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Pold3
|
response to virus
|
Microglial Cell Line
|
Gene: Pold3 (polymerase (DNA-directed), delta 3, accessory subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA synthesis involved in UV-damage excision repair, DNA-templated DNA replication, error-prone translesion synthesis, nucleotide-excision repair, DNA gap filling; MF: DNA-directed DNA polymerase activity, protein-macromolecule adaptor activity; CC: cytoplasm, delta DNA polymerase complex, nucleoplasm, nucleus, zeta DNA polymerase complex
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9EQ28
Entrez ID: 67967
|
Does Knockout of Cyp2f2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Cyp2f2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cyp2f2 (cytochrome P450, family 2, subfamily f, polypeptide 2)
Type: protein-coding
Summary: Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within naphthalene catabolic process and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; nose; pharyngo-tympanic tube; respiratory system; and sublingual gland primordium. Orthologous to several human genes including CYP2F1 (cytochrome P450 family 2 subfamily F member 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: epoxygenase P450 pathway, naphthalene catabolic process, response to toxic substance, trichloroethylene metabolic process, xenobiotic metabolic process; MF: arachidonate epoxygenase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, oxygen binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Biological oxidations, CYP2E1 reactions, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Cytochrome P450 - arranged by substrate type, Fatty acids, Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Phase I - Functionalization of compounds, Xenobiotics
UniProt: P33267
Entrez ID: 13107
|
Does Knockout of Tbc1d21 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Tbc1d21
|
response to virus
|
Microglial Cell Line
|
Gene: Tbc1d21 (TBC1 domain family, member 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, flagellated sperm motility, plasma membrane to endosome transport, sperm axoneme assembly, sperm mitochondrial sheath assembly, spermatogenesis; MF: GTPase activator activity, actin binding, protein binding, small GTPase binding; CC: acrosomal vesicle, cytoplasm, cytoplasmic vesicle, cytoskeleton, sperm midpiece
Pathways:
UniProt: Q9D9D3
Entrez ID: 74286
|
Does Knockout of Eloa in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Eloa
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Eloa (elongin A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter; CC: elongin complex, nucleoplasm, nucleus, site of DNA damage, transcription elongation factor complex
Pathways: Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q8CB77
Entrez ID: 27224
|
Does Knockout of Kdm4a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Kdm4a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kdm4a (lysine (K)-specific demethylase 4A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic chromosome condensation, cardiac muscle hypertrophy in response to stress, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of astrocyte differentiation, negative regulation of autophagy, negative regulation of gene expression, positive regulation of gene expression, positive regulation of neuron differentiation, regulation of gene expression; MF: dioxygenase activity, histone H3K36 demethylase activity, histone H3K36me2/H3K36me3 demethylase activity, histone H3K9 demethylase activity, histone H3K9me2/H3K9me3 demethylase activity, histone H4K20me2 reader activity, histone demethylase activity, metal ion binding, oxidoreductase activity, ubiquitin protein ligase binding, zinc ion binding; CC: chromatin, cytosol, fibrillar center, nucleoplasm, nucleus, pericentric heterochromatin
Pathways: Chromatin modifying enzymes, Chromatin organization, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, HDMs demethylate histones, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q8BW72
Entrez ID: 230674
|
Does Knockout of Vmn1r215 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Vmn1r215
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Vmn1r215 (vomeronasal 1 receptor 215)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R264
Entrez ID: 171253
|
Does Knockout of Ing5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Ing5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ing5 (inhibitor of growth family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication-dependent chromatin disassembly, chromatin organization, negative regulation of cell population proliferation, negative regulation of fibroblast proliferation, negative regulation of growth, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, regulation of DNA biosynthetic process, regulation of DNA replication, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell growth, regulation of developmental process, regulation of hemopoiesis; MF: chromatin binding, histone H3K4me3 reader activity, metal ion binding, zinc ion binding; CC: MOZ/MORF histone acetyltransferase complex, chromosome, histone acetyltransferase complex, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Transcriptional Regulation by TP53
UniProt: Q9D8Y8
Entrez ID: 66262
|
Does Knockout of Klf17 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Klf17
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Klf17 (Kruppel-like transcription factor 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gamete generation, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding
Pathways:
UniProt: Q8CFA7
Entrez ID: 75753
|
Does Knockout of Rgs10 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Rgs10
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rgs10 (regulator of G-protein signalling 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled acetylcholine receptor signaling pathway, negative regulation of signal transduction, positive regulation of GTPase activity, regulation of G protein-coupled receptor signaling pathway; MF: G-protein alpha-subunit binding, GTPase activator activity, protein binding; CC: axon terminus, cytoplasm, cytosol, dendritic spine, neuronal cell body, nuclear body, nucleoplasm, nucleus, synapse
Pathways:
UniProt: Q9CQE5
Entrez ID: 67865
|
Does Knockout of Galnt7 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Galnt7
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Galnt7 (polypeptide N-acetylgalactosaminyltransferase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein O-linked glycosylation, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism of proteins, Mucin type O-glycan biosynthesis - Mus musculus (mouse), O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification
UniProt: Q80VA0
Entrez ID: 108150
|
Does Knockout of Bex3 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Bex3
|
phagocytosis
|
macrophage
|
Gene: Bex3 (brain expressed X-linked 3)
Type: protein-coding
Summary: Enables death receptor binding activity and molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytosol. Is expressed in several structures, including genitourinary system; gut; liver; nervous system; and sensory organ. Orthologous to human BEX3 (brain expressed X-linked 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of protein ubiquitination, signal transduction; MF: death receptor binding, identical protein binding, metal ion binding, molecular function inhibitor activity, nerve growth factor receptor binding, signaling receptor binding; CC: cytoplasm, cytosol, nucleus
Pathways: Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, NADE modulates death signalling, Neurotrophin signaling pathway - Mus musculus (mouse), Signal Transduction, p75 NTR receptor-mediated signalling
UniProt: Q9WTZ9
Entrez ID: 12070
|
Does Knockout of Crebzf in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Crebzf
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Crebzf (CREB/ATF bZIP transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of gene expression, epigenetic, positive regulation of transcription by RNA polymerase II, regulation of DNA-binding transcription factor activity, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to virus; MF: DNA-binding transcription factor activity, identical protein binding, protein binding; CC: RNA polymerase II transcription regulator complex, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q91ZR3
Entrez ID: 233490
|
Does Knockout of Efnb3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Efnb3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Efnb3 (ephrin B3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell costimulation, adult walking behavior, axon choice point recognition, axon guidance, cell differentiation, cell-cell signaling, ephrin receptor signaling pathway, negative regulation of axonogenesis, nervous system development, positive regulation of presynapse assembly, positive regulation of synaptic transmission, trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission; MF: ephrin receptor binding, protein binding; CC: glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane, plasma membrane, postsynaptic density membrane, presynaptic membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHB-mediated forward signaling, Ephrin signaling, Nervous system development
UniProt: O35393
Entrez ID: 13643
|
Does Knockout of Timeless in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Timeless
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Timeless (timeless circadian clock 1)
Type: protein-coding
Summary: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication checkpoint signaling, branching involved in ureteric bud morphogenesis, branching morphogenesis of an epithelial tube, cell cycle phase transition, cell division, cellular response to bleomycin, cellular response to cisplatin, cellular response to hydroxyurea, circadian rhythm, kidney development, lung development, morphogenesis of an epithelium, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of circadian rhythm, positive regulation of double-strand break repair, positive regulation of double-strand break repair via homologous recombination, regulation of circadian rhythm, replication fork arrest, replication fork processing, rhythmic process; MF: DNA binding, enzyme activator activity, identical protein binding, protein binding; CC: chromatin, chromosome, nucleoplasm, nucleus, replication fork protection complex, site of double-strand break
Pathways: DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends
UniProt: Q9R1X4
Entrez ID: 21853
|
Does Knockout of Mrpl55 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Mrpl55
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Mrpl55 (mitochondrial ribosomal protein L55)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CZ83
Entrez ID: 67212
|
Does Knockout of Psg16 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Psg16
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Psg16 (pregnancy specific beta-1-glycoprotein 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, immune response; CC: cell surface, external side of plasma membrane
Pathways:
UniProt: D0VY58, Q8K0U8, Q60962, D3YXQ6
Entrez ID: 26436
|
Does Knockout of Acot7 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Acot7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Acot7 (acyl-CoA thioesterase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acyl-CoA metabolic process, coenzyme A biosynthetic process, fatty acid catabolic process, fatty acid metabolic process, lipid metabolic process, long-chain fatty-acyl-CoA catabolic process, medium-chain fatty acid biosynthetic process, medium-chain fatty-acyl-CoA catabolic process, palmitic acid biosynthetic process; MF: carboxylic ester hydrolase activity, fatty acyl-CoA hydrolase activity, fatty-acyl-CoA binding, hydrolase activity, identical protein binding, long-chain fatty acyl-CoA binding, long-chain fatty acyl-CoA hydrolase activity, protein homodimerization activity, thiolester hydrolase activity; CC: cytoplasm, cytosol, mitochondrial matrix, neuron projection, neuronal cell body, nucleoplasm
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, acyl-CoA hydrolysis
UniProt: Q91V12
Entrez ID: 70025
|
Does Knockout of Ptrhd1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Ptrhd1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ptrhd1 (peptidyl-tRNA hydrolase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, molecular_function, peptidyl-tRNA hydrolase activity
Pathways:
UniProt: D3Z4S3
Entrez ID: 69709
|
Does Knockout of Nsun5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Nsun5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nsun5 (NOL1/NOP2/Sun domain family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, cerebral cortex development, cognition, corpus callosum development, methylation, oligodendrocyte development, positive regulation of translation, rRNA base methylation, rRNA processing, regulation of myelination; MF: RNA binding, RNA methyltransferase activity, methyltransferase activity, rRNA (cytosine-C5-)-methyltransferase activity, transferase activity; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8K4F6
Entrez ID: 100609
|
Does Knockout of Vmn1r158 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Vmn1r158
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r158 (vomeronasal 1 receptor 158)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: G3UY92
Entrez ID: 100043067
|
Does Knockout of Rsl24d1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Rsl24d1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Rsl24d1 (ribosomal L24 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome biogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Ribosome - Mus musculus (mouse)
UniProt: Q99L28
Entrez ID: 225215
|
Does Knockout of Rnd3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Rnd3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rnd3 (Rho family GTPase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, regulation of actin cytoskeleton organization, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding; CC: Golgi apparatus, Golgi membrane, cytosol, membrane, plasma membrane
Pathways: RHO GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P61588
Entrez ID: 74194
|
Does Knockout of Nrde2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Nrde2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Nrde2 (nrde-2 necessary for RNA interference, domain containing)
Type: protein-coding
Summary: Predicted to be involved in several processes, including RNA splicing; negative regulation of macromolecule metabolic process; and positive regulation of RNA export from nucleus. Predicted to be located in nuclear speck and nucleolus. Orthologous to human NRDE2 (NRDE-2, necessary for RNA interference, domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, RNA processing, RNA splicing, cell division, mRNA processing, mRNA stabilization, mitotic cell cycle, negative regulation of RNA catabolic process, positive regulation of RNA export from nucleus, regulatory ncRNA-mediated heterochromatin formation; CC: nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q80XC6
Entrez ID: 217827
|
Does Knockout of Tgm2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Tgm2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tgm2 (transglutaminase 2, C polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, apoptotic cell clearance, blood vessel remodeling, bone development, branching involved in salivary gland morphogenesis, cellular response to cocaine, cellular response to dopamine, cellular response to serotonin, chromatin remodeling, dopamine secretion, gene expression, negative regulation of endoplasmic reticulum calcium ion concentration, peptide cross-linking, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of GTPase activity, positive regulation of apoptotic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell adhesion, positive regulation of mitochondrial calcium ion concentration, positive regulation of neurogenesis, positive regulation of small GTPase mediated signal transduction, positive regulation of smooth muscle cell proliferation, positive regulation of sprouting angiogenesis, protein deamination, protein homooligomerization, proteolysis, regulation of apoptotic cell clearance, regulation of apoptotic process, salivary gland cavitation; MF: GTP binding, acyltransferase activity, calcium ion binding, histone dopaminyltransferase activity, histone serotonyltransferase activity, hydrolase activity, identical protein binding, metal ion binding, nucleotide binding, peptidase activity, peptide dopaminyltransferase activity, peptide histaminyltransferase activity, peptide noradrenalinyltransferase activity, peptide serotonyltransferase activity, phospholipase binding, protein domain specific binding, protein-glutamine gamma-glutamyltransferase activity, protein-glutamine glutaminase activity, transaminase activity, transferase activity; CC: chromatin, chromosome, cytoplasm, cytosol, endoplasmic reticulum, extracellular matrix, extracellular region, membrane, mitochondrion, nucleosome, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Huntington disease - Mus musculus (mouse)
UniProt: P21981
Entrez ID: 21817
|
Does Knockout of Paox in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,157
|
Knockout
|
Paox
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Paox (polyamine oxidase (exo-N4-amino))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: polyamine catabolic process, positive regulation of spermidine biosynthetic process, putrescine biosynthetic process, putrescine catabolic process, spermidine catabolic process, spermine catabolic process, spermine metabolic process; MF: N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity, oxidoreductase activity, polyamine oxidase activity; CC: cytoplasm, peroxisomal matrix, peroxisome
Pathways: Amine Oxidase reactions, Biological oxidations, Interconversion of polyamines, Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, PAOs oxidise polyamines to amines, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Phase I - Functionalization of compounds, Protein localization
UniProt: Q8C0L6
Entrez ID: 212503
|
Does Knockout of Psen1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Psen1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Psen1 (presenilin 1)
Type: protein-coding
Summary: Enables aspartic-type endopeptidase activity and cadherin binding activity. Contributes to aspartic endopeptidase activity, intramembrane cleaving. Involved in several processes, including protein catabolic process at postsynapse; regulation of macromolecule metabolic process; and skin morphogenesis. Acts upstream of or within with a positive effect on L-glutamate import across plasma membrane; gene expression; and sequestering of calcium ion. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of protein kinase activity. Located in several cellular components, including ciliary rootlet; dendritic shaft; and growth cone. Part of gamma-secretase complex. Is active in glutamatergic synapse. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; genitourinary system; and hemolymphoid system. Used to study Alzheimer's disease and Alzheimer's disease 3. Human ortholog(s) of this gene implicated in Alzheimer's disease (multiple); dilated cardiomyopathy 1U; frontotemporal dementia (multiple); and hidradenitis suppurativa. Orthologous to human PSEN1 (presenilin 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Cajal-Retzius cell differentiation, DNA damage response, L-glutamate import across plasma membrane, Notch receptor processing, Notch signaling pathway, T cell activation involved in immune response, T cell receptor signaling pathway, amyloid precursor protein catabolic process, amyloid precursor protein metabolic process, amyloid-beta formation, amyloid-beta metabolic process, apoptotic process, astrocyte activation, astrocyte activation involved in immune response, autophagosome assembly, autophagy, blood vessel development, brain development, brain morphogenesis, calcium ion homeostasis, calcium ion transmembrane transport, cell adhesion, cell fate specification, cell-cell adhesion, cellular response to amyloid-beta, cerebellum development, cerebral cortex cell migration, cerebral cortex development, choline transport, dorsal/ventral neural tube patterning, embryonic limb morphogenesis, endoplasmic reticulum calcium ion homeostasis, epithelial cell proliferation, forebrain development, gene expression, heart development, heart looping, hematopoietic progenitor cell differentiation, intracellular calcium ion homeostasis, intracellular signal transduction, learning or memory, locomotion, long-term synaptic potentiation, membrane protein ectodomain proteolysis, memory, mitochondrial transport, myeloid dendritic cell differentiation, myeloid leukocyte differentiation, negative regulation of apoptotic process, negative regulation of apoptotic signaling pathway, negative regulation of axonogenesis, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of gene expression, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, neural retina development, neurogenesis, neuron apoptotic process, neuron cellular homeostasis, neuron development, neuron differentiation, neuron migration, neuron projection maintenance, positive regulation of DNA-templated transcription, positive regulation of L-glutamate import across plasma membrane, positive regulation of amyloid fibril formation, positive regulation of apoptotic process, positive regulation of coagulation, positive regulation of dendritic spine development, positive regulation of gene expression, positive regulation of glycolytic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein import into nucleus, positive regulation of receptor recycling, positive regulation of tumor necrosis factor production, post-embryonic development, protein catabolic process at postsynapse, protein glycosylation, protein maturation, protein processing, protein transport, proteolysis, regulation of canonical Wnt signaling pathway, regulation of gene expression, regulation of neuron projection development, regulation of postsynapse organization, regulation of resting membrane potential, regulation of synaptic plasticity, regulation of synaptic transmission, glutamatergic, regulation of synaptic vesicle cycle, response to oxidative stress, segmentation, sequestering of calcium ion, skeletal system morphogenesis, skin morphogenesis, smooth endoplasmic reticulum calcium ion homeostasis, somitogenesis, synapse organization, synaptic vesicle targeting, thymus development; MF: ATPase binding, PDZ domain binding, aspartic endopeptidase activity, intramembrane cleaving, aspartic-type endopeptidase activity, beta-catenin binding, cadherin binding, calcium channel activity, endopeptidase activity, growth factor receptor binding, hydrolase activity, peptidase activity, protein binding; CC: Golgi apparatus, Golgi membrane, aggresome, axon, cell cortex, cell junction, cell projection, cell surface, centrosome, ciliary rootlet, cytoplasm, cytoplasmic vesicle, dendrite, dendritic shaft, early endosome, early endosome membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, gamma-secretase complex, glutamatergic synapse, growth cone, kinetochore, lysosomal membrane, membrane, membrane raft, mitochondrial inner membrane, mitochondrion, neuromuscular junction, neuron projection, neuronal cell body, nuclear membrane, nuclear outer membrane, nucleoplasm, nucleus, plasma membrane, postsynapse, presynaptic membrane, protein-containing complex, rough endoplasmic reticulum, sarcolemma, smooth endoplasmic reticulum, synapse, synaptic membrane, synaptic vesicle
Pathways: Alzheimer disease - Mus musculus (mouse), Axon guidance, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, NOTCH3 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Noncanonical activation of NOTCH3, Notch signaling pathway - Mus musculus (mouse), Nuclear signaling by ERBB4, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Regulated proteolysis of p75NTR, Signal Transduction, Signaling by ERBB4, Signaling by NOTCH, Signaling by NOTCH3, Signaling by Receptor Tyrosine Kinases, Signaling by TGFB family members, Signaling by TGFBR3, TGFBR3 PTM regulation, Wnt signaling pathway - Mus musculus (mouse), p75 NTR receptor-mediated signalling
UniProt: P49769
Entrez ID: 19164
|
Does Knockout of Drc7 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Drc7
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Drc7 (dynein regulatory complex subunit 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, flagellated sperm motility, sperm axoneme assembly, spermatogenesis; CC: cell projection, cilium, cytoplasm, cytoskeleton, motile cilium
Pathways:
UniProt: Q6V3W6
Entrez ID: 330830
|
Does Knockout of Cbfb in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Cbfb
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cbfb (core binding factor beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell maturation, definitive hemopoiesis, lymphocyte differentiation, myeloid cell differentiation, negative regulation of CD4-positive, alpha-beta T cell differentiation, negative regulation of transcription by RNA polymerase II, ossification, osteoblast differentiation, positive regulation of CD8-positive, alpha-beta T cell differentiation, positive regulation of transcription by RNA polymerase II, protein polyubiquitination, regulation of transcription by RNA polymerase II; MF: DNA binding, protein binding, sequence-specific DNA binding, transcription coactivator activity; CC: core-binding factor complex, nucleoplasm, nucleus, protein-containing complex
Pathways: ESR-mediated signaling, Estrogen-dependent gene expression, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs), RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, RUNX1 regulates estrogen receptor mediated transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, RUNX1 regulates transcription of genes involved in BCR signaling, RUNX1 regulates transcription of genes involved in differentiation of HSCs, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells, RUNX1 regulates transcription of genes involved in interleukin signaling, RUNX2 regulates bone development, RUNX3 regulates p14-ARF, Regulation of RUNX1 Expression and Activity, Regulation of RUNX3 expression and activity, Signal Transduction, Signaling by Nuclear Receptors, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3
UniProt: Q08024
Entrez ID: 12400
|
Does Knockout of Esco2 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,553
|
Knockout
|
Esco2
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Esco2 (establishment of sister chromatid cohesion N-acetyltransferase 2)
Type: protein-coding
Summary: Enables L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Acts upstream of or within several processes, including double-strand break repair; hematopoietic progenitor cell differentiation; and protein localization to chromatin. Located in chromocenter and chromosome. Is expressed in several structures, including alimentary system; brain; gonad; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Roberts syndrome and lung adenocarcinoma. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromosome segregation, double-strand break repair, hematopoietic progenitor cell differentiation, mitotic sister chromatid cohesion, protein localization to chromatin, regulation of DNA replication; MF: L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, acetyltransferase activity, acyltransferase activity, metal ion binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: Golgi apparatus, XY body, cell junction, chromatin, chromocenter, chromosome, nucleoplasm, nucleus, pericentric heterochromatin, site of double-strand break
Pathways: Cell Cycle, Cell Cycle, Mitotic, Establishment of Sister Chromatid Cohesion, S Phase
UniProt: Q8CIB9
Entrez ID: 71988
|
Does Knockout of Bcan in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Bcan
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Bcan (brevican)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-matrix adhesion, central nervous system development, hippocampus development, neuron projection extension, skeletal system development, synapse maturation; MF: calcium ion binding, carbohydrate binding, hyaluronic acid binding; CC: GABA-ergic synapse, axon, axon initial segment, cell surface, dendrite, extracellular matrix, extracellular region, extracellular space, glutamatergic synapse, node of Ranvier, perineuronal net, perisynaptic extracellular matrix, synapse, synaptic membrane
Pathways: CS-GAG biosynthesis, CS/DS degradation, Chondroitin sulfate/dermatan sulfate metabolism, DS-GAG biosynthesis, Degradation of the extracellular matrix, ECM proteoglycans, Extracellular matrix organization, Glycosaminoglycan metabolism, Glycosaminoglycan-protein linkage region biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q61361
Entrez ID: 12032
|
Does Knockout of Hoxd10 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Hoxd10
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hoxd10 (homeobox D10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult locomotory behavior, anterior/posterior pattern specification, embryonic limb morphogenesis, embryonic skeletal system morphogenesis, forelimb morphogenesis, hindlimb morphogenesis, neuromuscular process, peripheral nervous system neuron development, positive regulation of transcription by RNA polymerase II, proximal/distal pattern formation, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II, single fertilization, skeletal muscle tissue development, skeletal system development, spinal cord motor neuron cell fate specification; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, protein binding, sequence-specific double-stranded DNA binding; CC: cytoplasmic ribonucleoprotein granule, cytosol, nucleoplasm, nucleus
Pathways: MicroRNAs in cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse)
UniProt: P28359
Entrez ID: 15430
|
Does Knockout of Tdrd1 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Tdrd1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Tdrd1 (tudor domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P granule organization, cell differentiation, germ cell development, meiotic cell cycle, piRNA processing, regulatory ncRNA-mediated gene silencing, spermatogenesis, transposable element silencing by piRNA-mediated DNA methylation; MF: metal ion binding, protein binding, zinc ion binding; CC: P granule, chromatoid body, cytoplasm, cytosol, pi-body, ribonucleoprotein complex, synapse
Pathways:
UniProt: Q99MV1
Entrez ID: 83561
|
Does Knockout of Angptl2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Angptl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Angptl2 (angiopoietin-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: Q9R045
Entrez ID: 26360
|
Does Knockout of Kdm8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,288
|
Knockout
|
Kdm8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kdm8 (lysine (K)-specific demethylase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, chromatin organization, chromatin remodeling, circadian regulation of gene expression, fibroblast proliferation, in utero embryonic development, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, protein destabilization, proteolysis, regulation of gene expression, regulation of signal transduction by p53 class mediator, rhythmic process; MF: aminopeptidase activity, chromatin binding, dioxygenase activity, endopeptidase activity, histone H3K36 demethylase activity, hydrolase activity, metal ion binding, oxidoreductase activity, p53 binding, peptidase activity, peptidyl-arginine 3-dioxygenase activity, protein binding; CC: chromosome, cytosol, nucleoplasm, nucleus
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Protein hydroxylation
UniProt: Q9CXT6
Entrez ID: 77035
|
Does Knockout of Gtsf1l in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Gtsf1l
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gtsf1l (gametocyte specific factor 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, protein-containing complex binding, zinc ion binding
Pathways:
UniProt: Q9CWD0
Entrez ID: 68236
|
Does Knockout of Tas2r125 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Tas2r125
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tas2r125 (taste receptor, type 2, member 125)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: Q7M710
Entrez ID: 387352
|
Does Knockout of Tspan7 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Tspan7
|
cell cycle progression
|
breast epithelium
|
Gene: Tspan7 (tetraspanin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane, postsynapse
Pathways: Glutamate binding, activation of AMPA receptors and synaptic plasticity, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transcriptional misregulation in cancer - Mus musculus (mouse), Transmission across Chemical Synapses
UniProt: Q62283
Entrez ID: 21912
|
Does Knockout of Fry in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Fry
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fry (FRY microtubule binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell morphogenesis, negative regulation of tubulin deacetylation, neuron projection development; CC: cell cortex, centrosome, cytoplasm, cytoskeleton, site of polarized growth, spindle pole
Pathways:
UniProt: E9Q8I9
Entrez ID: 320365
|
Does Knockout of Hspe1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Hspe1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hspe1 (heat shock protein 1 (chaperonin 10))
Type: protein-coding
Summary: Predicted to enable metal ion binding activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Located in mitochondrion. Is expressed in brain; brainstem nucleus; early conceptus; and midbrain ventricular layer. Orthologous to human HSPE1 (heat shock protein family E (Hsp10) member 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: protein folding; MF: ATP binding, metal ion binding, protein folding chaperone, protein-folding chaperone binding, unfolded protein binding; CC: mitochondrial matrix, mitochondrion
Pathways: RHO GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q64433
Entrez ID: 15528
|
Does Knockout of Clstn1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Clstn1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Clstn1 (calsyntenin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, chemical synaptic transmission, homophilic cell adhesion via plasma membrane adhesion molecules, intracellular calcium ion homeostasis, neurotransmitter receptor transport to postsynaptic membrane, positive regulation of synapse assembly, positive regulation of synaptic transmission, regulation of cell growth, regulation of synapse maturation, vesicle-mediated transport in synapse; MF: X11-like protein binding, amyloid-beta binding, calcium ion binding, kinesin binding, protein binding; CC: GABA-ergic synapse, Golgi apparatus, Golgi membrane, cell projection, cell surface, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular region, glutamatergic synapse, membrane, neuron projection, nucleus, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic endosome, postsynaptic membrane, spine apparatus membrane, synapse, vesicle
Pathways:
UniProt: Q9EPL2
Entrez ID: 65945
|
Does Knockout of Ankrd39 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Ankrd39
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ankrd39 (ankyrin repeat domain 39)
Type: protein-coding
Summary: Is expressed in dorsal root ganglion and ventral grey horn. Orthologous to human ANKRD39 (ankyrin repeat domain 39). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q9D2X0
Entrez ID: 109346
|
Does Knockout of Clec4a4 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Clec4a4
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Clec4a4 (C-type lectin domain family 4, member a4)
Type: protein-coding
Summary: Enables carbohydrate derivative binding activity. Predicted to be involved in several processes, including antifungal innate immune response; negative regulation of tumor necrosis factor production; and plasmacytoid dendritic cell antigen processing and presentation. Predicted to be active in external side of plasma membrane. Is expressed in ductus deferens; epididymis; and prostate gland. Orthologous to human CLEC4A (C-type lectin domain family 4 member A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: CD8-positive, alpha-beta T cell activation, adaptive immune response, antifungal innate immune response, antigen processing and presentation of exogenous peptide antigen via MHC class I, immune system process, innate immune response, negative regulation of cytokine production, negative regulation of tumor necrosis factor production, plasmacytoid dendritic cell antigen processing and presentation; MF: D-mannose binding, calcium ion binding, carbohydrate binding, carbohydrate derivative binding, metal ion binding, pattern recognition receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q5YIR8
Entrez ID: 474145
|
Does Knockout of Mlc1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Mlc1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mlc1 (megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: caveolin-mediated endocytosis, cellular response to cholesterol, monoatomic ion transmembrane transport, positive regulation of intracellular transport, protein transport, regulation of response to osmotic stress, vesicle-mediated transport; MF: identical protein binding, monoatomic ion channel activity, protein binding, protein-containing complex binding; CC: apical plasma membrane, astrocyte end-foot, basolateral plasma membrane, caveola, cell-cell junction, cytoplasm, cytoplasmic vesicle, cytosol, early endosome, endoplasmic reticulum, endosome, lysosome, membrane, membrane raft, perinuclear region of cytoplasm, plasma membrane, recycling endosome
Pathways:
UniProt: Q8VHK5
Entrez ID: 170790
|
Does Knockout of Ptpru in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Ptpru
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ptpru (protein tyrosine phosphatase receptor type U)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ regeneration, cell adhesion, cell differentiation, homotypic cell-cell adhesion, negative regulation of canonical Wnt signaling pathway, negative regulation of cell migration, negative regulation of cell population proliferation, neuron projection development, positive regulation of cell-cell adhesion mediated by cadherin, protein localization to cell surface, response to glucocorticoid, signal transduction; MF: beta-catenin binding, hydrolase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity; CC: anchoring junction, cell-cell junction, membrane, plasma membrane
Pathways: Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT
UniProt: B1AUH1
Entrez ID: 19273
|
Does Knockout of Plpp5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Plpp5
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Plpp5 (phospholipid phosphatase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, phospholipid dephosphorylation, phospholipid metabolic process; MF: diacylglycerol diphosphate phosphatase activity, hydrolase activity, phosphatidate phosphatase activity; CC: membrane, plasma membrane
Pathways: Fcgamma receptor (FCGR) dependent phagocytosis, Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid metabolism - Mus musculus (mouse), Immune System, Innate Immune System, Role of phospholipids in phagocytosis
UniProt: Q3UMZ3
Entrez ID: 71910
|
Does Knockout of Enpp3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Enpp3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Enpp3 (ectonucleotide pyrophosphatase/phosphodiesterase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, basophil activation involved in immune response, negative regulation of cGAS/STING signaling pathway, negative regulation of inflammatory response, negative regulation of mast cell activation involved in immune response, negative regulation of mast cell proliferation, nucleoside triphosphate catabolic process, phosphate ion homeostasis, phosphate-containing compound metabolic process, pyrimidine nucleotide metabolic process; MF: ATP binding, ATP diphosphatase activity, GTP diphosphatase activity, UTP diphosphatase activity, bis(5'-adenosyl)-pentaphosphatase activity, bis(5'-adenosyl)-triphosphatase activity, bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity, calcium ion binding, catalytic activity, cyclic-GMP-AMP hydrolase activity, hydrolase activity, metal ion binding, nucleic acid binding, nucleoside triphosphate diphosphatase activity, nucleotide binding, phosphodiesterase I activity, zinc ion binding; CC: apical plasma membrane, cell surface, external side of plasma membrane, extracellular region, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Pantothenate and CoA biosynthesis - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), Riboflavin metabolism - Mus musculus (mouse), Starch and sucrose metabolism - Mus musculus (mouse)
UniProt: Q6DYE8
Entrez ID: 209558
|
Does Knockout of Plekhg1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Plekhg1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Plekhg1 (pleckstrin homology domain containing, family G (with RhoGef domain) member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, small GTPase binding; CC: cytosol, nucleoplasm
Pathways:
UniProt: Q3V3S7, Q3UX37, A0A5F8MPP0, F6S200, F7C583, F7CES2
Entrez ID: 213783
|
Does Knockout of Nup43 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Nup43
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nup43 (nucleoporin 43)
Type: protein-coding
Summary: Predicted to be involved in nucleocytoplasmic transport. Predicted to be located in cytosol; nuclear envelope; and nuclear speck. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Is expressed in several structures, including gut; lung; olfactory epithelium; tooth; and urinary system. Orthologous to human NUP43 (nucleoporin 43). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, chromosome segregation, mRNA transport, nucleocytoplasmic transport, protein transport; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, nuclear envelope, nuclear pore, nuclear pore outer ring, nuclear speck, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: P59235
Entrez ID: 69912
|
Does Knockout of Bean1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Bean1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Bean1 (brain expressed, associated with Nedd4, 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways: Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q9EQG5
Entrez ID: 65115
|
Does Knockout of Smarcb1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Smarcb1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Smarcb1 (SWI/SNF related BAF chromatin remodeling complex subunit B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, blastocyst development, blastocyst hatching, chromatin organization, chromatin remodeling, hepatocyte differentiation, host-mediated activation of viral transcription, negative regulation of cell population proliferation, nervous system development, nucleosome disassembly, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of double-strand break repair, positive regulation of glucose mediated signaling pathway, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, single stranded viral RNA replication via double stranded DNA intermediate, transcription initiation-coupled chromatin remodeling; MF: DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, Tat protein binding, identical protein binding, p53 binding, protein binding, transcription coactivator activity; CC: RSC-type complex, SWI/SNF complex, XY body, bBAF complex, brahma complex, chromatin, fibrillar center, germ cell nucleus, kinetochore, nBAF complex, npBAF complex, nuclear chromosome, nuclear matrix, nucleolus, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: Q9Z0H3
Entrez ID: 20587
|
Does Knockout of Bdp1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Bdp1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Bdp1 (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase III preinitiation complex assembly, regulation of DNA-templated transcription; CC: nucleoplasm, nucleus, transcription factor TFIIIB complex
Pathways: Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter
UniProt: Q571C7
Entrez ID: 544971
|
Does Knockout of Nup214 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Nup214
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nup214 (nucleoporin 214)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, intracellular protein transport, mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein export from nucleus, protein import into nucleus, protein transport, regulation of cell cycle, regulation of nucleocytoplasmic transport; MF: nuclear export signal receptor activity, nuclear localization sequence binding, structural constituent of nuclear pore; CC: cytoplasmic side of nuclear pore, nuclear envelope, nuclear pore, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HuR (ELAVL1) binds and stabilizes mRNA, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Regulation of mRNA stability by proteins that bind AU-rich elements, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q80U93
Entrez ID: 227720
|
Does Knockout of Snx7 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Snx7
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Snx7 (sorting nexin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, mitophagy, piecemeal microautophagy of the nucleus, positive regulation of autophagosome assembly, protein transport, reticulophagy; MF: lipid binding, phosphatidylinositol binding, protein binding; CC: cytoplasm, early endosome, early endosome membrane, endosome, membrane, phagophore assembly site
Pathways:
UniProt: Q9CY18
Entrez ID: 76561
|
Does Knockout of Mrpl45 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Mrpl45
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mrpl45 (mitochondrial ribosomal protein L45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D0Q7
Entrez ID: 67036
|
Does Knockout of Snrpd3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Snrpd3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Snrpd3 (small nuclear ribonucleoprotein D3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal snRNP assembly; MF: RNA binding, U1 snRNP binding, U7 snRNA binding, enzyme binding, histone pre-mRNA DCP binding, telomerase RNA binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, commitment complex, cytoplasm, cytosol, methylosome, nuclear body, nucleoplasm, nucleus, pICln-Sm protein complex, precatalytic spliceosome, ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex, telomerase holoenzyme complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62320
Entrez ID: 67332
|
Does Knockout of Pcdhb22 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Pcdhb22
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pcdhb22 (protocadherin beta 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, photoreceptor connecting cilium, plasma membrane
Pathways:
UniProt: Q8C8Z3, Q91XZ8, Q52KQ3
Entrez ID: 93893
|
Does Knockout of Nup50 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Nup50
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Nup50 (nucleoporin 50)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA transport, neural tube formation, nucleocytoplasmic transport, protein import into nucleus, protein transport; CC: membrane, nuclear envelope, nuclear membrane, nuclear pore, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q9JIH2
Entrez ID: 18141
|
Does Knockout of Zfp319 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Zfp319
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp319 (zinc finger protein 319)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q9ERR8
Entrez ID: 79233
|
Does Knockout of Cdv3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Cdv3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cdv3 (carnitine deficiency-associated gene expressed in ventricle 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, plasma membrane
Pathways:
UniProt: Q4VAA2
Entrez ID: 321022
|
Does Knockout of Ints3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ints3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ints3 (integrator complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II transcription initiation surveillance, double-strand break repair via homologous recombination, mitotic G2/M transition checkpoint, response to ionizing radiation, snRNA processing; CC: INTAC complex, SOSS complex, cytoplasm, integrator complex, nucleus, site of double-strand break
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q7TPD0
Entrez ID: 229543
|
Does Knockout of Gpr85 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Gpr85
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gpr85 (G protein-coupled receptor 85)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: endoplasmic reticulum, membrane, plasma membrane
Pathways:
UniProt: P60894
Entrez ID: 64450
|
Does Knockout of Krt13 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Krt13
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Krt13 (keratin 13)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cellular response to retinoic acid, cytoskeleton organization, epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium, regulation of translation in response to stress, tongue morphogenesis; MF: protein binding, structural constituent of skin epidermis, structural molecule activity; CC: cytoskeleton, extracellular exosome, intermediate filament, intermediate filament cytoskeleton, keratin filament
Pathways: Developmental Biology, Estrogen signaling pathway - Mus musculus (mouse), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: P08730
Entrez ID: 16663
|
Does Knockout of Ctu2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ctu2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ctu2 (cytosolic thiouridylase subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification; MF: nucleotidyltransferase activity, sulfurtransferase activity, tRNA binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Sulfur relay system - Mus musculus (mouse)
UniProt: Q3U308
Entrez ID: 66965
|
Does Knockout of Lig4 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Lig4
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Lig4 (ligase IV, DNA, ATP-dependent)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DN2 thymocyte differentiation, DNA biosynthetic process, DNA damage response, DNA recombination, DNA repair, T cell receptor V(D)J recombination, V(D)J recombination, base-excision repair, cell division, cellular response to ionizing radiation, cellular response to lithium ion, central nervous system development, chromosome organization, double-strand break repair, double-strand break repair via classical nonhomologous end joining, double-strand break repair via nonhomologous end joining, fibroblast proliferation, immunoglobulin V(D)J recombination, in utero embryonic development, isotype switching, negative regulation of neuron apoptotic process, neuron apoptotic process, nucleotide-excision repair, DNA gap filling, positive regulation of chromosome organization, positive regulation of fibroblast proliferation, positive regulation of neurogenesis, pro-B cell differentiation, response to X-ray, response to gamma radiation, response to ionizing radiation, single strand break repair, somatic stem cell population maintenance, stem cell proliferation; MF: AMP binding, ATP binding, DNA binding, DNA ligase (ATP) activity, DNA ligase activity, ligase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding; CC: DNA ligase IV complex, DNA-dependent protein kinase-DNA ligase 4 complex, condensed chromosome, nonhomologous end joining complex, nucleoplasm, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ)
UniProt: Q8BTF7
Entrez ID: 319583
|
Does Knockout of Cdh5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Cdh5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cdh5 (cadherin 5)
Type: protein-coding
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein die in utero due to vascular insufficiency, caused by increased endothelial apoptosis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: adherens junction organization, bicellular tight junction assembly, blood vessel endothelial cell migration, blood vessel maturation, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell migration involved in sprouting angiogenesis, cell morphogenesis, cell surface receptor signaling pathway, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, endothelial cell morphogenesis, homophilic cell adhesion via plasma membrane adhesion molecules, intracellular calcium ion homeostasis, negative regulation of cell population proliferation, negative regulation of endothelial cell apoptotic process, negative regulation of inflammatory response, negative regulation of microtubule polymerization, positive regulation of BMP signaling pathway, positive regulation of angiogenesis, positive regulation of cell migration, positive regulation of establishment of endothelial barrier, positive regulation of gene expression, positive regulation of intracellular signal transduction, positive regulation of protein-containing complex assembly, protein localization to bicellular tight junction, regulation of establishment of cell polarity, regulation of vascular permeability, transforming growth factor beta receptor signaling pathway; MF: BMP receptor binding, beta-catenin binding, cadherin binding, calcium ion binding, cell-cell adhesion mediator activity, fibrinogen binding, metal ion binding, protein binding, protein phosphatase binding, protein tyrosine kinase binding, signaling receptor binding, signaling receptor complex adaptor activity, transmembrane transporter binding, vascular endothelial growth factor receptor 2 binding; CC: adherens junction, anchoring junction, bicellular tight junction, catenin complex, cell junction, cell periphery, cell surface, cell-cell junction, cytoplasm, external side of plasma membrane, membrane, nuclear membrane, nucleoplasm, plasma membrane
Pathways: Adherens junctions interactions, Cell adhesion molecules - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability
UniProt: P55284
Entrez ID: 12562
|
Does Knockout of Hes6 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Hes6
|
phagocytosis
|
macrophage
|
Gene: Hes6 (hairy and enhancer of split 6)
Type: protein-coding
Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Acts upstream of or within cell differentiation; nervous system development; and regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anterior/posterior pattern specification, cell differentiation, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of neurogenesis, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, sequence-specific double-stranded DNA binding, transcription regulator inhibitor activity; CC: nucleus, transcription regulator complex
Pathways: Human papillomavirus infection - Mus musculus (mouse)
UniProt: Q9JHE6
Entrez ID: 55927
|
Does Knockout of Spcs3 in macrophage causally result in phagocytosis?
| 1
| 1,888
|
Knockout
|
Spcs3
|
phagocytosis
|
macrophage
|
Gene: Spcs3 (signal peptidase complex subunit 3 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein targeting to ER, proteolysis, signal peptide processing, viral protein processing; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, signal peptidase complex
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Metabolism of proteins, Peptide hormone metabolism, Protein export - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Synthesis, secretion, and deacylation of Ghrelin
UniProt: Q6ZWQ7
Entrez ID: 76687
|
Does Knockout of Mrpl41 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Mrpl41
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Mrpl41 (mitochondrial ribosomal protein L41)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CQN7
Entrez ID: 107733
|
Does Knockout of Umps in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Umps
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Umps (uridine monophosphate synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' UMP biosynthetic process, 'de novo' pyrimidine nucleobase biosynthetic process, UDP biosynthetic process, UMP biosynthetic process, pyrimidine nucleobase biosynthetic process, pyrimidine nucleotide biosynthetic process; MF: carboxy-lyase activity, catalytic activity, glycosyltransferase activity, identical protein binding, lyase activity, orotate phosphoribosyltransferase activity, orotidine-5'-phosphate decarboxylase activity, transferase activity; CC: cytoplasm, nucleus
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Pyrimidine biosynthesis, Pyrimidine metabolism - Mus musculus (mouse), pyrimidine ribonucleotides <i>de novo</i> biosynthesis, uridine-5,-phosphate biosynthesis
UniProt: P13439
Entrez ID: 22247
|
Does Knockout of Wdr77 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Wdr77
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Wdr77 (WD repeat domain 77)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation involved in prostate gland development, oocyte axis specification, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of mRNA splicing, via spliceosome, protein polyubiquitination, regulation of transcription by RNA polymerase II, secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development, spliceosomal snRNP assembly, ubiquitin-dependent protein catabolic process; MF: methyl-CpG binding, protein binding, transcription coactivator activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul4B-RING E3 ubiquitin ligase complex, Golgi apparatus, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, transferase complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Metabolism of RNA, Metabolism of non-coding RNA, RMTs methylate histone arginines, snRNP Assembly
UniProt: Q99J09
Entrez ID: 70465
|
Does Knockout of Itgam in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Itgam
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Itgam (integrin alpha M)
Type: protein-coding
Summary: Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; complement-mediated synapse pruning; and endocytosis. Acts upstream of or within several processes, including activated T cell proliferation; microglia development; and neutrophil chemotaxis. Located in external side of plasma membrane and nucleus. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; hemolymphoid system; renal interstitium; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis; persistent fetal circulation syndrome; and pre-eclampsia. Orthologous to human ITGAM (integrin subunit alpha M). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: activated T cell proliferation, amyloid-beta clearance, cell adhesion, cell-cell adhesion, cell-matrix adhesion, cellular extravasation, complement receptor mediated signaling pathway, complement-mediated synapse pruning, forebrain development, integrin-mediated signaling pathway, leukocyte adhesion to vascular endothelial cell, leukocyte cell-cell adhesion, leukocyte migration involved in inflammatory response, microglia development, microglial cell activation, negative regulation of dopamine metabolic process, neutrophil apoptotic process, neutrophil chemotaxis, phagocytosis, phagocytosis, engulfment, positive regulation of mast cell differentiation, positive regulation of microglial cell mediated cytotoxicity, positive regulation of neutrophil degranulation, positive regulation of protein targeting to membrane, positive regulation of superoxide anion generation, receptor-mediated endocytosis, vertebrate eye-specific patterning; MF: cargo receptor activity, complement component C3b binding, heat shock protein binding, heparan sulfate proteoglycan binding, heparin binding, metal ion binding, opsonin binding, protein binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, extracellular space, integrin alphaM-beta2 complex, integrin complex, membrane, membrane raft, nucleus, plasma membrane, plasma membrane raft
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Complement and coagulation cascades - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Legionellosis - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: G5E8F1, E9Q604, E9Q5K8, A0A0R4J1B4, D6RJ73
Entrez ID: 16409
|
Does Knockout of Fdft1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Fdft1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fdft1 (farnesyl diphosphate farnesyl transferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, farnesyl diphosphate metabolic process, isoprenoid biosynthetic process, lipid biosynthetic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: catalytic activity, metal ion binding, squalene synthase [NAD(P)H] activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: cytoplasmic side of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, Steroid biosynthesis - Mus musculus (mouse), cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), epoxysqualene biosynthesis, superpathway of cholesterol biosynthesis
UniProt: P53798
Entrez ID: 14137
|
Does Knockout of Ppcdc in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Ppcdc
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ppcdc (phosphopantothenoylcysteine decarboxylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: coenzyme A biosynthetic process; MF: FMN binding, carboxy-lyase activity, catalytic activity, identical protein binding, lyase activity, phosphopantothenoylcysteine decarboxylase activity
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q8BZB2
Entrez ID: 66812
|
Does Knockout of Hmga2 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,545
|
Knockout
|
Hmga2
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Hmga2 (high mobility group AT-hook 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, adrenal gland development, base-excision repair, cell division, cell proliferation in forebrain, chondrocyte differentiation, chondrocyte proliferation, chromosome condensation, endodermal cell differentiation, epithelial to mesenchymal transition, epithelial tube branching involved in lung morphogenesis, fat cell differentiation, fat pad development, heterochromatin formation, host-mediated suppression of viral transcription, intracellular signal transduction, lung epithelium development, male gonad development, meiotic cell cycle, mesenchymal cell differentiation, mesodermal cell differentiation, mesodermal-endodermal cell signaling, multicellular organism growth, negative regulation of DNA binding, negative regulation of DNA-templated transcription, negative regulation of Wnt signaling pathway, negative regulation of apoptotic process, negative regulation of astrocyte differentiation, negative regulation of cellular senescence, negative regulation of double-strand break repair via nonhomologous end joining, negative regulation of intracellular steroid hormone receptor signaling pathway, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, negative regulation of transcription by RNA polymerase II, oncogene-induced cell senescence, pituitary gland development, positive regulation of DNA-templated transcription, positive regulation of angiogenesis, positive regulation of cell population proliferation, positive regulation of cell proliferation in bone marrow, positive regulation of epithelial cell proliferation involved in lung morphogenesis, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of multicellular organism growth, positive regulation of protein serine/threonine kinase activity, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle process, regulation of gene expression, regulation of growth hormone secretion, regulation of peptide hormone secretion, regulation of stem cell population maintenance, response to virus, somatic stem cell population maintenance, spermatogenesis, stem cell differentiation; MF: 5'-deoxyribose-5-phosphate lyase activity, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending, DNA-(apurinic or apyrimidinic site) endonuclease activity, MH1 domain binding, MH2 domain binding, RNA polymerase II-specific DNA-binding transcription factor binding, SMAD binding, cAMP response element binding, enzyme binding, minor groove of adenine-thymine-rich DNA binding, nucleic acid binding, nucleosomal DNA binding, protein binding, transcription cis-regulatory region binding, transcription coregulator activity, transcription corepressor activity; CC: SMAD protein complex, chromatin, male germ cell nucleus, nuclear chromosome, nucleus, protein-DNA complex, senescence-associated heterochromatin focus
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, DNA Damage/Telomere Stress Induced Senescence, Formation of Senescence-Associated Heterochromatin Foci (SAHF), MicroRNAs in cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P52927
Entrez ID: 15364
|
Does Knockout of Cenpw in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Cenpw
|
phagocytosis
|
macrophage
|
Gene: Cenpw (centromere protein W)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, chromosome organization, chromosome segregation, kinetochore assembly, mitotic cell cycle; MF: DNA binding, molecular_function, protein heterodimerization activity; CC: chromosome, chromosome, centromeric region, inner kinetochore, kinetochore, nuclear matrix, nucleolus, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, Nucleosome assembly
UniProt: Q3URR0
Entrez ID: 66311
|
Does Knockout of Bcas3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Bcas3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Bcas3 (BCAS3 microtubule associated cell migration factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, autophagy, cell-cell signaling, cellular response to estrogen stimulus, positive regulation of catalytic activity, positive regulation of endothelial cell migration, positive regulation of transcription by RNA polymerase II, regulation of actin cytoskeleton organization, response to estrogen, response to starvation; MF: GTPase activator activity, acetyltransferase activator activity, beta-tubulin binding, chromatin binding, histone acetyltransferase binding, histone binding, nuclear receptor binding, phosphatidylinositol binding; CC: cell leading edge, cell periphery, cytoplasm, cytoplasmic microtubule, cytoskeleton, euchromatin, intermediate filament cytoskeleton, nucleus, phagophore assembly site
Pathways:
UniProt: Q8CCN5
Entrez ID: 192197
|
Does Knockout of Polk in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Polk
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Polk (polymerase (DNA directed), kappa)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, cellular response to UV, error-prone translesion synthesis, nucleotide-excision repair, DNA gap filling; MF: DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, damaged DNA binding, metal ion binding, molecular adaptor activity, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: nuclear body, nucleoplasm, nucleus, site of DNA damage
Pathways: Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Fanconi anemia pathway - Mus musculus (mouse), Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatocellular carcinoma - Mus musculus (mouse), Homology Directed Repair, Melanoma - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Nucleotide Excision Repair, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Termination of translesion DNA synthesis, Thyroid cancer - Mus musculus (mouse), Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional misregulation in cancer - Mus musculus (mouse), Translesion synthesis by POLK, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9QUG2
Entrez ID: 27015
|
Does Knockout of Morf4l2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Morf4l2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Morf4l2 (mortality factor 4 like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair; CC: NuA4 histone acetyltransferase complex, nucleolus, nucleoplasm, nucleosome, nucleus, plasma membrane
Pathways:
UniProt: Q9R0Q4
Entrez ID: 56397
|
Does Knockout of Sema4c in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Sema4c
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Sema4c (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C)
Type: protein-coding
Summary: This gene encodes a member of the semaphorin family of proteins that have diverse functions in neuronal development, heart morphogenesis, vascular growth, tumor progression and immune cell regulation. Lack of the encoded protein in some mice causes exencephaly resulting in neonatal lethality. Mice that bypass exencephaly show no obvious behavioral defects but display distinct pigmentation defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: axon guidance, cell differentiation, cell migration in hindbrain, cerebellum development, muscle cell differentiation, negative chemotaxis, nervous system development, neural crest cell migration, neural tube closure, positive regulation of cell migration, positive regulation of stress-activated MAPK cascade, regulation of postsynapse assembly, semaphorin-plexin signaling pathway; MF: chemorepellent activity, neuropilin binding, protein binding, semaphorin receptor binding; CC: cytoplasmic vesicle, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, synapse, synaptic vesicle membrane
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q64151
Entrez ID: 20353
|
Does Knockout of Il5 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Il5
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Il5 (interleukin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, eosinophil differentiation, immune response, interleukin-5-mediated signaling pathway, positive regulation of B cell proliferation, positive regulation of cell population proliferation, positive regulation of eosinophil differentiation, positive regulation of immunoglobulin production, positive regulation of podosome assembly, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of transcription by RNA polymerase II; MF: cytokine activity, growth factor activity, interleukin-5 receptor binding; CC: extracellular region, extracellular space
Pathways: Allograft rejection - Mus musculus (mouse), Asthma - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intestinal immune network for IgA production - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Pathways in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Signal Transduction, Signaling by Interleukins, T cell receptor signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse)
UniProt: P04401
Entrez ID: 16191
|
Does Knockout of Slc3a2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Slc3a2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Slc3a2 (solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alanine import across plasma membrane, L-histidine transport, L-leucine import across plasma membrane, L-leucine transport, amino acid transport, carbohydrate metabolic process, isoleucine transport, methionine transport, neutral amino acid transport, phenylalanine transport, proline transport, response to exogenous dsRNA, symbiont entry into host cell, thyroid hormone transport, tryptophan transport, tyrosine transport, valine transport; MF: L-alanine transmembrane transporter activity, L-leucine transmembrane transporter activity, aromatic amino acid transmembrane transporter activity, double-stranded RNA binding, exogenous protein binding, neutral L-amino acid transmembrane transporter activity, protein binding, protein heterodimerization activity, protein homodimerization activity; CC: amino acid transport complex, anchoring junction, apical plasma membrane, apical pole of neuron, basal plasma membrane, basolateral plasma membrane, cell surface, lysosomal membrane, lysosome, melanosome, membrane, neuronal cell body, nucleoplasm, plasma membrane, synapse
Pathways: Amino acid transport across the plasma membrane, Basigin interactions, Cell surface interactions at the vascular wall, Ferroptosis - Mus musculus (mouse), Hemostasis, Metabolism, Metabolism of amino acids and derivatives, Protein digestion and absorption - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transport of small molecules, Tryptophan catabolism, mTOR signaling pathway - Mus musculus (mouse)
UniProt: P10852
Entrez ID: 17254
|
Does Knockout of Gramd4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Gramd4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Gramd4 (GRAM domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of toll-like receptor 9 signaling pathway, positive regulation of apoptotic process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q8CB44
Entrez ID: 223752
|
Does Knockout of Cyp7b1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Cyp7b1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cyp7b1 (cytochrome P450, family 7, subfamily b, polypeptide 1)
Type: protein-coding
Summary: Predicted to enable oxysterol 7-alpha-hydroxylase activity. Involved in B cell chemotaxis and bile acid biosynthetic process. Acts upstream of or within negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of epithelial cell proliferation; and prostate gland epithelium morphogenesis. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A. Orthologous to human CYP7B1 (cytochrome P450 family 7 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: B cell chemotaxis, bile acid biosynthetic process, cholesterol homeostasis, cholesterol metabolic process, circadian rhythm, digestion, lipid metabolic process, memory, negative regulation of intracellular estrogen receptor signaling pathway, positive regulation of epithelial cell proliferation, prostate gland epithelium morphogenesis, small molecule metabolic process, steroid biosynthetic process, steroid metabolic process; MF: 24S-hydroxycholesterol 7-alpha-hydroxylase activity, 25-hydroxycholesterol 7-alpha-hydroxylase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, steroid hydroxylase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Bile acid and bile salt metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, Endogenous sterols, Metabolism, Metabolism of lipids, Metabolism of steroids, Phase I - Functionalization of compounds, Primary bile acid biosynthesis - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), Synthesis of bile acids and bile salts, Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
UniProt: Q60991
Entrez ID: 13123
|
Does Knockout of Bdkrb1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Bdkrb1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Bdkrb1 (bradykinin receptor, beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell migration, inflammatory response, negative regulation of blood pressure, negative regulation of cell growth, positive regulation of leukocyte migration, positive regulation of release of sequestered calcium ion into cytosol, response to lipopolysaccharide, response to mechanical stimulus, signal transduction; MF: G protein-coupled receptor activity, bradykinin receptor activity, peptide binding; CC: membrane, plasma membrane
Pathways: Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Complement and coagulation cascades - Mus musculus (mouse), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Peptide ligand-binding receptors, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q61125
Entrez ID: 12061
|
Does Knockout of Dusp18 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Dusp18
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dusp18 (dual specificity phosphatase 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dephosphorylation, peptidyl-threonine dephosphorylation, peptidyl-tyrosine dephosphorylation, protein targeting to membrane, protein targeting to mitochondrion, response to antibiotic; MF: MAP kinase tyrosine/serine/threonine phosphatase activity, hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity; CC: cytoplasm, extrinsic component of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q8VE01
Entrez ID: 75219
|
Does Knockout of Rpl29 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,536
|
Knockout
|
Rpl29
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rpl29 (ribosomal protein L29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-substrate adhesion, cytoplasmic translation, fibroblast proliferation, multicellular organism growth, translation, translation at postsynapse, translation at presynapse; MF: heparin binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P47915
Entrez ID: 19944
|
Does Knockout of Cyp2c68 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Cyp2c68
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cyp2c68 (cytochrome P450, family 2, subfamily c, polypeptide 68)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epoxygenase P450 pathway, estrogen metabolic process, icosanoid biosynthetic process, lipid hydroxylation, organic acid metabolic process, oxidative demethylation, retinoic acid metabolic process, steroid metabolic process, xenobiotic catabolic process, xenobiotic metabolic process; MF: arachidonate epoxygenase activity, arachidonate monooxygenase activity, caffeine oxidase activity, estrogen 16-alpha-hydroxylase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, retinoic acid 4-hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, plasma membrane
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse)
UniProt: K7N6C2
Entrez ID: 433247
|
Does Knockout of Dclre1b in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,523
|
Knockout
|
Dclre1b
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Dclre1b (DNA cross-link repair 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via nonhomologous end joining, interstrand cross-link repair, nucleotide-excision repair, protection from non-homologous end joining at telomere, telomere capping, telomere maintenance, telomere maintenance via telomere lengthening, telomeric 3' overhang formation, telomeric loop formation; MF: 5'-3' DNA exonuclease activity, 5'-3' exonuclease activity, beta-lactamase activity, damaged DNA binding, exonuclease activity, hydrolase activity, nuclease activity, protein binding, protein homodimerization activity, protein-containing complex binding; CC: centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytoskeleton, nuclear body, nucleoplasm, nucleus
Pathways: DNA Repair, Fanconi Anemia Pathway
UniProt: Q8C7W7
Entrez ID: 140917
|
Does Knockout of Tmem248 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Tmem248
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tmem248 (transmembrane protein 248)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q3TBN1
Entrez ID: 71667
|
Does Knockout of Epg5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Epg5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Epg5 (ectopic P-granules 5 autophagy tethering factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure homeostasis, apoptotic process, autophagosome maturation, autophagy, cellular response to dsDNA, defense response to virus, endocytic recycling, endosome to lysosome transport, gene expression, homeostasis of number of cells, homeostasis of number of retina cells, host-mediated modulation of intestinal microbiota composition, inclusion body assembly, inflammatory response, innate immune response, interferon-mediated signaling pathway, intracellular receptor signaling pathway, maintenance of protein complex location, mucosal immune response, neuron apoptotic process, nucleotide transport, photoreceptor cell differentiation, protein aggregate center assembly, protein catabolic process, response to type III interferon, response to unfolded protein, response to virus, toll-like receptor 9 signaling pathway, ubiquitin-dependent protein catabolic process; CC: cytoplasm, lysosome, perinuclear region of cytoplasm
Pathways:
UniProt: Q80TA9
Entrez ID: 100502841
|
Does Knockout of Usp18 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,158
|
Knockout
|
Usp18
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Usp18 (ubiquitin specific peptidase 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, negative regulation of type I interferon-mediated signaling pathway, protein deubiquitination, proteolysis, regulation of inflammatory response, regulation of protein stability, response to bacterium, response to other organism, response to stilbenoid; MF: ISG15-specific peptidase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, molecular adaptor activity, peptidase activity, protein binding; CC: cytosol, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Deubiquitination, ISG15 antiviral mechanism, Immune System, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Post-translational protein modification, Regulation of IFNA/IFNB signaling, Regulation of NF-kappa B signaling, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ub-specific processing proteases
UniProt: Q9WTV6
Entrez ID: 24110
|
Does Knockout of Fam107b in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Fam107b
|
phagocytosis
|
macrophage
|
Gene: Fam107b (family with sequence similarity 107, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3TGF2
Entrez ID: 66540
|
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