prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Tyk2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Tyk2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tyk2 (tyrosine kinase 2)
Type: protein-coding
Summary: Predicted to enable growth hormone receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and type 1 angiotensin receptor binding activity. Involved in cell population proliferation and positive regulation of T cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of interleukin-12 receptor complex and interleukin-23 receptor complex. Predicted to be active in cytosol. Used to study obesity. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human TYK2 (tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell differentiation, cell population proliferation, cell surface receptor signaling pathway via JAK-STAT, cytokine-mediated signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, immune response, interleukin-10-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-23-mediated signaling pathway, intracellular signal transduction, positive regulation of NK T cell proliferation, positive regulation of T cell proliferation, positive regulation of T-helper 17 type immune response, positive regulation of interleukin-17 production, positive regulation of natural killer cell proliferation, positive regulation of protein localization to nucleus, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of type II interferon production, regulation of T cell activation, regulation of leukocyte cell-cell adhesion, regulation of transcription by RNA polymerase II, type I interferon-mediated signaling pathway, type II interferon-mediated signaling pathway; MF: ATP binding, growth hormone receptor binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, type 1 angiotensin receptor binding; CC: cytoplasm, cytosol, interleukin-12 receptor complex, interleukin-23 receptor complex, membrane, nucleus, plasma membrane, receptor complex
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IL-6-type cytokine receptor ligand interactions, Immune System, Inactivation of CSF3 (G-CSF) signaling, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, Interleukin-10 signaling, Interleukin-12 family signaling, Interleukin-12 signaling, Interleukin-20 family signaling, Interleukin-23 signaling, Interleukin-27 signaling, Interleukin-35 Signalling, Interleukin-4 and Interleukin-13 signaling, Interleukin-6 family signaling, Interleukin-6 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), MAPK family signaling cascades, MAPK1 (ERK2) activation, MAPK1/MAPK3 signaling, MAPK3 (ERK1) activation, Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), RAF-independent MAPK1/3 activation, Regulation of IFNA/IFNB signaling, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by Interleukins, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse)
UniProt: Q9R117
Entrez ID: 54721
|
Does Knockout of Cyp2d12 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Cyp2d12
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Cyp2d12 (cytochrome P450, family 2, subfamily d, polypeptide 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, xenobiotic metabolic process; MF: anandamide 11,12 epoxidase activity, anandamide 14,15 epoxidase activity, anandamide 8,9 epoxidase activity, aromatase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, mitochondrion
Pathways: Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse)
UniProt: Q8BVD2, B7ZP10, A0A2R8VHA2, A0A2R8VJY6
Entrez ID: 380997
|
Does Knockout of Syt6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Syt6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Syt6 (synaptotagmin VI)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acrosomal vesicle exocytosis, acrosome reaction, chemical synaptic transmission, postsynaptic dense core vesicle exocytosis, regulation of calcium ion-dependent exocytosis, vesicle-mediated transport; MF: SNARE binding, calcium ion sensor activity, calcium-dependent phospholipid binding, calcium-dependent protein binding, clathrin binding, identical protein binding, metal ion binding, phosphatidylserine binding, phospholipid binding, protein binding, protein heterodimerization activity, protein homodimerization activity, syntaxin binding; CC: cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytosol, exocytic vesicle, glutamatergic synapse, membrane, perinuclear endoplasmic reticulum, plasma membrane, synapse, synaptic membrane, synaptic vesicle membrane
Pathways:
UniProt: Q9R0N8
Entrez ID: 54524
|
Does Knockout of Phf12 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Phf12
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Phf12 (PHD finger protein 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II; MF: metal ion binding, phosphatidylinositol binding, protein binding, transcription corepressor activity, transcription corepressor binding, zinc ion binding; CC: Sin3-type complex, nucleoplasm, nucleus, transcription repressor complex
Pathways:
UniProt: Q5SPL2
Entrez ID: 268448
|
Does Knockout of Rtp1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Rtp1
|
cell cycle progression
|
breast epithelium
|
Gene: Rtp1 (receptor transporter protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detection of chemical stimulus involved in sensory perception of bitter taste, protein insertion into membrane, protein targeting to membrane; MF: metal ion binding, olfactory receptor binding, zinc ion binding; CC: cell surface, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q8C8C1
Entrez ID: 239766
|
Does Knockout of Gtf2h2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Gtf2h2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gtf2h2 (general transcription factor II H, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, nucleotide-excision repair, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: RNA polymerase II general transcription initiation factor activity, metal ion binding, zinc ion binding; CC: core TFIIH complex portion of holo TFIIH complex, nuclear speck, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Mus musculus (mouse), DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral carcinogenesis - Mus musculus (mouse), mRNA Capping
UniProt: Q9JIB4
Entrez ID: 23894
|
Does Knockout of Atrip in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Atrip
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Atrip (ATR interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, nucleobase-containing compound metabolic process, regulation of double-strand break repair; MF: K63-linked polyubiquitin modification-dependent protein binding, protein binding; CC: ATR-ATRIP complex, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q8BMG1
Entrez ID: 235610
|
Does Knockout of Mtmr14 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 1
| 1,522
|
Knockout
|
Mtmr14
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Mtmr14 (myotubularin related protein 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity, phosphatidylinositol-3-phosphate phosphatase activity; CC: cytoplasm, perinuclear region of cytoplasm, ruffle
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), D-<i>myo</i>-inositol-5-phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Macroautophagy, Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Synthesis of PIPs at the plasma membrane
UniProt: Q8VEL2
Entrez ID: 97287
|
Does Knockout of Nop58 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Nop58
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Nop58 (NOP58 ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal small subunit biogenesis, ribosome biogenesis, snoRNA localization; MF: ATPase binding, RNA binding, TFIID-class transcription factor complex binding, snoRNA binding; CC: Cajal body, box C/D methylation guide snoRNP complex, cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus, pre-snoRNP complex, ribonucleoprotein complex, small-subunit processome, sno(s)RNA-containing ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Post-translational protein modification, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of RNA binding proteins, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6DFW4
Entrez ID: 55989
|
Does Knockout of Ei24 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Ei24
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ei24 (etoposide induced 2.4 mRNA)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, autophagy, cellular response to UV-C, intrinsic apoptotic signaling pathway in response to DNA damage, macroautophagy, negative regulation of cell growth, negative regulation of protein import into nucleus, neuromuscular process controlling balance, positive regulation of intrinsic apoptotic signaling pathway, response to xenobiotic stimulus; MF: importin-alpha family protein binding; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nucleus
Pathways: p53 signaling pathway - Mus musculus (mouse)
UniProt: Q61070
Entrez ID: 13663
|
Does Knockout of Alg5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Alg5
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Alg5 (ALG5 dolichyl-phosphate beta-glucosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: determination of left/right symmetry, dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein glycosylation; MF: dolichyl-phosphate beta-glucosyltransferase activity, glycosyltransferase activity, transferase activity; CC: cytoplasmic side of rough endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Synthesis of dolichyl-phosphate-glucose, Synthesis of substrates in N-glycan biosythesis, dolichyl-diphosphooligosaccharide biosynthesis
UniProt: Q9DB25
Entrez ID: 66248
|
Does Knockout of Zfp37 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Zfp37
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zfp37 (zinc finger protein 37)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within germ cell development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; foregut; and genitourinary system. Orthologous to human ZFP37 (ZFP37 zinc finger protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, germ cell development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: P17141
Entrez ID: 22696
|
Does Knockout of Ankle1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Ankle1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ankle1 (ankyrin repeat and LEM domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, determination of adult lifespan, double-strand break repair via homologous recombination, erythrocyte maturation, negative regulation of mitotic recombination, protein export from nucleus, regulation of B cell differentiation, regulation of T cell differentiation in thymus, regulation of alpha-beta T cell differentiation, regulation of lymphoid progenitor cell differentiation, regulation of myeloid progenitor cell differentiation, resolution of meiotic recombination intermediates; MF: DNA endonuclease activity, cobalt ion binding, endonuclease activity, hydrolase activity, magnesium ion binding, manganese ion binding, nuclease activity; CC: cytoplasm, cytosol, midbody, nucleoplasm, nucleus
Pathways:
UniProt: A8VU90
Entrez ID: 234396
|
Does Knockout of Serpina12 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Serpina12
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Serpina12 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of gluconeogenesis, negative regulation of lipid biosynthetic process, positive regulation of insulin receptor signaling pathway, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of cholesterol metabolic process, regulation of triglyceride metabolic process; MF: molecular function inhibitor activity, peptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space, plasma membrane
Pathways:
UniProt: Q7TMF5
Entrez ID: 68054
|
Does Knockout of Rev1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rev1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rev1 (REV1, DNA directed polymerase)
Type: protein-coding
Summary: Enables deoxycytidyl transferase activity. Acts upstream of or within error-prone translesion synthesis. Predicted to be located in nucleus. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA metabolic process, DNA repair, error-free translesion synthesis, error-prone translesion synthesis, response to UV, somatic hypermutation of immunoglobulin genes, translesion synthesis; MF: DNA binding, DNA-directed DNA polymerase activity, damaged DNA binding, deoxycytidyl transferase activity, metal ion binding, nucleotidyltransferase activity, protein binding, protein-macromolecule adaptor activity, transferase activity, ubiquitin binding; CC: nuclear replication fork, nucleus, site of DNA damage
Pathways: DNA Damage Bypass, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), Termination of translesion DNA synthesis, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q920Q2
Entrez ID: 56210
|
Does Knockout of Dnlz in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Dnlz
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Dnlz (DNL-type zinc finger)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chaperone-mediated protein complex assembly, protein folding, protein import into mitochondrial matrix, protein stabilization; MF: metal ion binding, protein folding chaperone, protein-folding chaperone binding, zinc ion binding; CC: cytosol, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q9D113
Entrez ID: 52838
|
Does Knockout of Sc5d in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Sc5d
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sc5d (sterol-C5-desaturase)
Type: protein-coding
Summary: Predicted to enable C-5 sterol desaturase activity and delta7-sterol 5(6)-desaturase activity. Predicted to be involved in cholesterol biosynthetic process via lathosterol and negative regulation of ferroptosis. Predicted to be active in endoplasmic reticulum membrane. Is expressed in central nervous system; ganglia; gut; and liver lobe. Orthologous to human SC5D (sterol-C5-desaturase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, lipid biosynthetic process, lipid metabolic process, negative regulation of ferroptosis, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: C-5 sterol desaturase activity, delta7-sterol 5(6)-desaturase activity, iron ion binding, oxidoreductase activity, sterol desaturase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Cholesterol biosynthesis, Cholesterol biosynthesis via desmosterol, Metabolism, Metabolism of lipids, Metabolism of steroids, Steroid biosynthesis - Mus musculus (mouse), cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), superpathway of cholesterol biosynthesis
UniProt: O88822
Entrez ID: 235293
|
Does Knockout of Hcfc1r1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Hcfc1r1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hcfc1r1 (host cell factor C1 regulator 1 (XPO1-dependent))
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q9CYQ5
Entrez ID: 353502
|
Does Knockout of Shq1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Shq1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Shq1 (SHQ1 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: box H/ACA snoRNP assembly, positive regulation of TORC1 signaling, protein-RNA complex assembly, regulation of androgen receptor signaling pathway; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q7TMX5
Entrez ID: 72171
|
Does Knockout of Tal2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Tal2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tal2 (T cell acute lymphocytic leukemia 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: midbrain development, multicellular organism growth, post-embryonic development, regulation of transcription by RNA polymerase II, thalamus development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein dimerization activity
Pathways:
UniProt: Q62282
Entrez ID: 21350
|
Does Knockout of Tfdp1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Tfdp1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tfdp1 (transcription factor Dp 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anoikis, epidermis development, negative regulation of fat cell proliferation, positive regulation of DNA-templated transcription, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of transcription by RNA polymerase II, regulation of DNA biosynthetic process, regulation of DNA-templated transcription, regulation of cell cycle, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cis-regulatory region sequence-specific DNA binding, protein binding, protein domain specific binding, transcription regulator inhibitor activity; CC: RNA polymerase II transcription regulator complex, Rb-E2F complex, cytoplasm, cytosol, nucleoplasm, nucleus, transcription regulator complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cyclin D associated events in G1, G0 and Early G1, G1 Phase, Gene expression (Transcription), Generic Transcription Pathway, Mitotic G1 phase and G1/S transition, RNA Polymerase II Transcription, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta signaling pathway - Mus musculus (mouse), Transcriptional Regulation by E2F6, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
UniProt: Q08639
Entrez ID: 21781
|
Does Knockout of Rapgef1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Rapgef1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Rapgef1 (Rap guanine nucleotide exchange factor (GEF) 1)
Type: protein-coding
Summary: Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including activation of GTPase activity; negative regulation of signal transduction; and platelet-derived growth factor receptor signaling pathway. Predicted to be located in early endosome; perinuclear region of cytoplasm; and phagocytic vesicle membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Rap protein signal transduction, Ras protein signal transduction, blood vessel development, cell-cell adhesion, cellular response to cAMP, cellular response to nerve growth factor stimulus, establishment of endothelial barrier, negative regulation of ERK1 and ERK2 cascade, negative regulation of Ras protein signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of neural precursor cell proliferation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, nerve growth factor signaling pathway, platelet-derived growth factor receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of Fc receptor mediated stimulatory signaling pathway, positive regulation of neuron projection development, positive regulation of phagocytosis, regulation of JNK cascade, regulation of cell junction assembly, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, protein binding; CC: cytoplasm, early endosome, perinuclear region of cytoplasm, phagocytic vesicle membrane, plasma membrane, protein-containing complex
Pathways: Cytokine Signaling in Immune system, Downstream signal transduction, Erythropoietin activates RAS, Focal adhesion - Mus musculus (mouse), Frs2-mediated activation, Immune System, Insulin signaling pathway - Mus musculus (mouse), Interleukin-3, Interleukin-5 and GM-CSF signaling, MET activates RAP1 and RAC1, MET promotes cell motility, Neurotrophin signaling pathway - Mus musculus (mouse), Prolonged ERK activation events, RAC3 GTPase cycle, RHO GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Regulation of signaling by CBL, Renal cell carcinoma - Mus musculus (mouse), Signal Transduction, Signaling by Erythropoietin, Signaling by Interleukins, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signalling to ERKs
UniProt: A1L338, Q91ZZ2, Q3UHC1, Q3UGX8, A0A5F8MPI9, Q8C5V7, F6ZDE5
Entrez ID: 107746
|
Does Knockout of Rfk in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Rfk
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Rfk (riboflavin kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: FMN biosynthetic process, apoptotic process, flavin adenine dinucleotide biosynthetic process, reactive oxygen species metabolic process, riboflavin biosynthetic process, riboflavin metabolic process; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, riboflavin kinase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Riboflavin metabolism - Mus musculus (mouse), Vitamin B2 (riboflavin) metabolism, flavin biosynthesis IV (mammalian), riboflavin, FMN and FAD transformations
UniProt: Q8CFV9
Entrez ID: 54391
|
Does Knockout of Gins3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Gins3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gins3 (GINS complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, cellular senescence, multicellular organism growth; CC: CMG complex, GINS complex, chromosome, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA strand elongation, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: Q9CY94
Entrez ID: 78833
|
Does Knockout of Smarcc1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Smarcc1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Smarcc1 (SWI/SNF related BAF chromatin remodeling complex subunit C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, chromatin organization, chromatin remodeling, chromosome organization, insulin receptor signaling pathway, negative regulation of cell differentiation, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, nervous system development, nucleosome disassembly, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, prostate gland development, regulation of DNA-templated transcription, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: chromatin binding, histone binding, protein binding; CC: GBAF complex, RSC-type complex, SWI/SNF complex, XY body, brahma complex, chromatin, cytoplasm, kinetochore, male germ cell nucleus, nBAF complex, npBAF complex, nuclear lumen, nuclear matrix, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: P97496
Entrez ID: 20588
|
Does Knockout of Stac in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Stac
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Stac (src homology three (SH3) and cysteine rich domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to heat, muscle contraction, positive regulation of cation channel activity, positive regulation of protein localization to plasma membrane, positive regulation of voltage-gated calcium channel activity, skeletal muscle contraction; MF: metal ion binding, transmembrane transporter binding, zinc ion binding; CC: T-tubule, cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane, plasma membrane, sarcolemma
Pathways:
UniProt: P97306
Entrez ID: 20840
|
Does Knockout of Vps33a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,288
|
Knockout
|
Vps33a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vps33a (VPS33A CORVET/HOPS core subunit)
Type: protein-coding
Summary: Acts upstream of or within pigmentation; platelet formation; and regulation of developmental pigmentation. Located in autophagosome and lysosome. Part of CORVET complex. Is expressed in ganglia. Used to study Hermansky-Pudlak syndrome. Orthologous to human VPS33A (VPS33A core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: autophagosome maturation, autophagy, endosome to lysosome transport, intracellular protein transport, lysosome localization, melanosome localization, pigmentation, platelet formation, protein transport, regulation of developmental pigmentation, regulation of lysosomal lumen pH, vesicle-mediated transport; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, autophagosome, clathrin complex, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q9D2N9
Entrez ID: 77573
|
Does Knockout of Zmiz2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Zmiz2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zmiz2 (zinc finger, MIZ-type containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, protein sumoylation, regulation of transcription by RNA polymerase II; MF: SUMO ligase activity, metal ion binding, transcription coactivator activity, zinc ion binding; CC: chromatin, mitochondrion, nuclear replication fork, nucleoplasm, nucleus
Pathways:
UniProt: Q8CIE2
Entrez ID: 52915
|
Does Knockout of Cwc15 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Cwc15
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cwc15 (CWC15 spliceosome-associated protein)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome. Predicted to be located in mitochondrion and nuclear speck. Predicted to be part of Prp19 complex and U2-type catalytic step 2 spliceosome. Orthologous to human CWC15 (CWC15 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding; CC: Prp19 complex, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, mitochondrion, nuclear speck, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9JHS9
Entrez ID: 66070
|
Does Knockout of Gna11 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Gna11
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gna11 (guanine nucleotide binding protein, alpha 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, action potential, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cellular response to pH, cranial skeletal system development, developmental pigmentation, endothelin receptor signaling pathway, heart development, ligand-gated ion channel signaling pathway, phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, phospholipase C-activating dopamine receptor signaling pathway, phospholipase C-activating serotonin receptor signaling pathway, positive regulation of insulin secretion, regulation of blood pressure, regulation of melanocyte differentiation, signal transduction, skeletal system development; MF: G protein activity, G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, alkylglycerophosphoethanolamine phosphodiesterase activity, enzyme regulator activity, guanyl nucleotide binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein-containing complex binding; CC: cytoplasm, heterotrimeric G-protein complex, membrane, plasma membrane, presynapse, synapse
Pathways: ADP signalling through P2Y purinoceptor 1, Acetylcholine regulates insulin secretion, Aldosterone synthesis and secretion - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chagas disease - Mus musculus (mouse), Chaperonin-mediated protein folding, Cholinergic synapse - Mus musculus (mouse), Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Free fatty acids regulate insulin secretion, G alpha (i) signalling events, G alpha (q) signalling events, G-protein activation, G-protein mediated events, GPCR downstream signalling, Gap junction - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Integration of energy metabolism, Long-term depression - Mus musculus (mouse), Metabolism, Metabolism of proteins, Opioid Signalling, PLC beta mediated events, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, Protein folding, Regulation of insulin secretion, Response of endothelial cells to shear stress, Signal Transduction, Signal amplification, Signaling by GPCR, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), cyclic AMP biosynthesis
UniProt: P21278
Entrez ID: 14672
|
Does Knockout of Timm8b in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Timm8b
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Timm8b (translocase of inner mitochondrial membrane 8B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: P62077
Entrez ID: 30057
|
Does Knockout of Lrrc8b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Lrrc8b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lrrc8b (leucine rich repeat containing 8 family, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aspartate transmembrane transport, cyclic-GMP-AMP transmembrane import across plasma membrane, monoatomic anion transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, transmembrane transport; MF: volume-sensitive anion channel activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, monoatomic ion channel complex, plasma membrane
Pathways: Miscellaneous transport and binding events, Transport of small molecules
UniProt: Q5DU41
Entrez ID: 433926
|
Does Knockout of Lztfl1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Lztfl1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Lztfl1 (leucine zipper transcription factor-like 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within flagellated sperm motility and spermatogenesis. Located in cilium; cytoplasm; and manchette. Is expressed in several structures, including brain; sensory organ; testis; and upper jaw incisor. Used to study Bardet-Biedl syndrome 17. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 17. Orthologous to human LZTFL1 (leucine zipper transcription factor like 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: flagellated sperm motility, negative regulation of protein localization to ciliary membrane, negative regulation of protein localization to cilium, spermatogenesis; MF: identical protein binding, protein binding, protein-containing complex binding; CC: cilium, cytoplasm, cytosol, manchette
Pathways: BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q9JHQ5
Entrez ID: 93730
|
Does Knockout of Nle1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Nle1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nle1 (notchless homolog 1)
Type: protein-coding
Summary: Acts upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and positive regulation of canonical Wnt signaling pathway. Located in nucleolus. Is expressed in several structures, including 2-cell stage embryo; gonad; hemolymphoid system gland; inner cell mass; and liver. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Notch signaling pathway, hematopoietic stem cell homeostasis, inner cell mass cell differentiation, kidney development, negative regulation of mitotic cell cycle, positive regulation of canonical Wnt signaling pathway, regulation of Notch signaling pathway, ribosomal large subunit biogenesis, skeletal system morphogenesis, somitogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8VEJ4
Entrez ID: 217011
|
Does Knockout of Hsd17b12 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Hsd17b12
|
cell cycle progression
|
breast epithelium
|
Gene: Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen biosynthetic process, extracellular matrix organization, fatty acid biosynthetic process, fatty acid elongation, saturated fatty acid, lipid metabolic process, positive regulation of cell-substrate adhesion, steroid biosynthetic process; MF: collagen binding, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, fibronectin binding, heparin binding, oxidoreductase activity, very-long-chain 3-oxoacyl-CoA reductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, extracellular matrix, fatty acid elongase complex, membrane
Pathways: Androgen biosynthesis, Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Steroid hormone biosynthesis - Mus musculus (mouse), Synthesis of very long-chain fatty acyl-CoAs, biosynthesis of estrogens
UniProt: O70503
Entrez ID: 56348
|
Does Knockout of Chtop in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Chtop
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Chtop (chromatin target of PRMT1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, in utero embryonic development, mRNA export from nucleus; MF: RNA binding, methyl-CpG binding, protein binding; CC: nuclear speck, nucleolus, nucleoplasm, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q9CY57
Entrez ID: 66511
|
Does Knockout of Sirt6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Sirt6
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Sirt6 (sirtuin 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, Ras protein signal transduction, base-excision repair, cardiac muscle cell differentiation, cellular response to angiotensin, cellular response to endothelin, cellular response to hydrogen peroxide, chromatin organization, chromatin remodeling, circadian regulation of gene expression, determination of adult lifespan, double-strand break repair, gluconeogenesis, glucose homeostasis, glycolytic process, inflammatory response, ketone biosynthetic process, negative regulation of D-glucose import, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of cellular senescence, negative regulation of gene expression, epigenetic, negative regulation of gluconeogenesis, negative regulation of glycolytic process, negative regulation of protein import into nucleus, negative regulation of protein localization to chromatin, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, pericentric heterochromatin formation, positive regulation of blood vessel branching, positive regulation of cellular senescence, positive regulation of chondrocyte proliferation, positive regulation of cold-induced thermogenesis, positive regulation of double-strand break repair, positive regulation of fat cell differentiation, positive regulation of fibroblast proliferation, positive regulation of gluconeogenesis, positive regulation of insulin secretion, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein export from nucleus, positive regulation of protein localization to chromatin, positive regulation of stem cell differentiation, positive regulation of stem cell population maintenance, positive regulation of stem cell proliferation, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial cell proliferation, post-embryonic cardiac muscle cell growth involved in heart morphogenesis, protein deacetylation, protein delipidation, protein destabilization, protein import into nucleus, protein localization to site of double-strand break, protein poly-ADP-ribosylation, regulation of circadian rhythm, regulation of double-strand break repair via homologous recombination, regulation of lipid catabolic process, regulation of lipid metabolic process, regulation of protein export from nucleus, regulation of protein localization to plasma membrane, regulation of protein secretion, response to UV, response to nutrient levels, subtelomeric heterochromatin formation, transcription pausing by RNA polymerase II, transposable element silencing; MF: DNA binding, DNA damage sensor activity, NAD+ binding, NAD+-protein mono-ADP-ribosyltransferase activity, NAD+-protein-arginine ADP-ribosyltransferase activity, NAD+-protein-lysine ADP-ribosyltransferase activity, NAD-dependent protein demyristoylase activity, NAD-dependent protein depalmitoylase activity, NAD-dependent protein lysine deacetylase activity, RNA binding, TORC2 complex binding, acyltransferase activity, chromatin DNA binding, chromatin binding, damaged DNA binding, enzyme regulator activity, glycosyltransferase activity, histone H3K18 deacetylase activity, NAD-dependent, histone H3K56 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, hydrolytic mechanism, histone deacetylase activity, NAD-dependent, histone deacetylase regulator activity, lncRNA binding, metal ion binding, nucleosome binding, nucleotidyltransferase activity, protein homodimerization activity, protein lysine deacetylase activity, transcription corepressor activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, chromosome, subtelomeric region, chromosome, telomeric region, endoplasmic reticulum, nucleolus, nucleoplasm, nucleus, pericentric heterochromatin, site of DNA damage, site of double-strand break
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Processing of DNA double-strand break ends, Thermogenesis - Mus musculus (mouse)
UniProt: P59941
Entrez ID: 50721
|
Does Knockout of Cnot1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Cnot1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cnot1 (CCR4-NOT transcription complex, subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: miRNA-mediated post-transcriptional gene silencing, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of retinoic acid receptor signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of translation, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of cytoplasmic mRNA processing body assembly, positive regulation of mRNA catabolic process, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, regulation of stem cell population maintenance, regulation of translation, regulatory ncRNA-mediated gene silencing, trophectodermal cell differentiation; MF: armadillo repeat domain binding, molecular adaptor activity, nuclear estrogen receptor binding, nuclear retinoic acid receptor binding, poly(A)-specific ribonuclease activity, protein binding, protein domain specific binding; CC: CCR4-NOT complex, CCR4-NOT core complex, P-body, cytoplasm, cytosol, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Polymerase II Transcription, RNA degradation - Mus musculus (mouse), TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: Q6ZQ08
Entrez ID: 234594
|
Does Knockout of Ipo11 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ipo11
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ipo11 (importin 11)
Type: protein-coding
Summary: Enables nuclear import signal receptor activity. Acts upstream of or within ribosomal protein import into nucleus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including early conceptus; germ cell of gonad; and islets of Langerhans. Orthologous to human IPO11 (importin 11). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: intracellular protein transport, nucleocytoplasmic transport, protein import into nucleus, protein transport, ribosomal protein import into nucleus; MF: nuclear import signal receptor activity, protein binding, small GTPase binding; CC: cytoplasm, cytosol, nuclear envelope, nucleoplasm, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q8K2V6
Entrez ID: 76582
|
Does Knockout of Galnt15 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Galnt15
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Galnt15 (polypeptide N-acetylgalactosaminyltransferase 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein O-linked glycosylation, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, molecular_function, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane, transport vesicle
Pathways: Metabolism of proteins, Mucin type O-glycan biosynthesis - Mus musculus (mouse), O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification
UniProt: Q9D2N8
Entrez ID: 78754
|
Does Knockout of Coq6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Coq6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Coq6 (coenzyme Q6 monooxygenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ubiquinone biosynthetic process; MF: 2-methoxy-6-polyprenolphenol 4-hydroxylase activity, 4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity, FAD binding, flavin adenine dinucleotide binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: Golgi apparatus, cell projection, extrinsic component of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion, ubiquinone biosynthesis complex
Pathways: Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Ubiquinol biosynthesis, Ubiquinone and other terpenoid-quinone biosynthesis - Mus musculus (mouse)
UniProt: Q8R1S0
Entrez ID: 217707
|
Does Knockout of Mir703 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Mir703
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Mir703 (microRNA 703)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 735265
|
Does Knockout of Vmn2r39 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Vmn2r39
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn2r39 (vomeronasal 2, receptor 39)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: L7N2E5
Entrez ID: 545909
|
Does Knockout of Kdm5d in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Kdm5d
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kdm5d (lysine demethylase 5D)
Type: protein-coding
Summary: Predicted to enable histone H3K4me/H3K4me2/H3K4me3 demethylase activity and nuclear androgen receptor binding activity. Acts upstream of or within T cell antigen processing and presentation. Predicted to be located in fibrillar center. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and lung. Orthologous to human KDM5D (lysine demethylase 5D). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: T cell antigen processing and presentation, chromatin organization, chromatin remodeling, regulation of DNA-templated transcription, regulation of androgen receptor signaling pathway; MF: DNA binding, dioxygenase activity, histone H3K4 demethylase activity, histone H3K4me/H3K4me2/H3K4me3 demethylase activity, metal ion binding, nuclear androgen receptor binding, oxidoreductase activity, zinc ion binding; CC: chromatin, fibrillar center, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones
UniProt: Q62240
Entrez ID: 20592
|
Does Knockout of Gpat3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Gpat3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gpat3 (glycerol-3-phosphate acyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, glycerol-3-phosphate metabolic process, glycerolipid metabolic process, lipid metabolic process, phospholipid biosynthetic process, regulation of TOR signaling, triglyceride biosynthetic process; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, O-acyltransferase activity, acyltransferase activity, glycerol-3-phosphate O-acyltransferase activity, protein binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA, phosphatidylglycerol biosynthesis I (plastidic), phosphatidylglycerol biosynthesis II (non-plastidic), phospholipid biosynthesis I, triacylglycerol biosynthesis
UniProt: Q8C0N2
Entrez ID: 231510
|
Does Knockout of Hsf2bp in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Hsf2bp
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Hsf2bp (heat shock transcription factor 2 binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: double-strand break repair involved in meiotic recombination, female meiosis I, male meiosis I, spermatogenesis; CC: chromosome, cytoplasm, cytosol, nucleoplasm
Pathways:
UniProt: Q9D4G2
Entrez ID: 74377
|
Does Knockout of Fabp1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Fabp1
|
cell cycle progression
|
breast epithelium
|
Gene: Fabp1 (fatty acid binding protein 1, liver)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose transmembrane transport, acylglycerol biosynthetic process, acylglycerol metabolic process, adult feeding behavior, aldehyde metabolic process, arachidonate metabolic process, bile acid metabolic process, bile acid secretion, cannabinoid signaling pathway, cell population proliferation, cellular detoxification, cellular oxidant detoxification, cellular response to hydrogen peroxide, cellular response to hypoxia, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, chylomicron assembly, connective tissue replacement, digestive system process, digestive tract development, diterpenoid metabolic process, endocannabinoid signaling pathway, energy homeostasis, establishment of localization in cell, fatty acid beta-oxidation, fatty acid biosynthetic process, fatty acid derivative metabolic process, fatty acid metabolic process, fatty acid oxidation, fatty acid primary amide metabolic process, fatty acid transport, gene expression, glucose metabolic process, glutamine metabolic process, glutathione metabolic process, glycerol metabolic process, glycolytic process, hepatic stellate cell activation, inflammatory response, intestinal absorption, intracellular signaling cassette, ketone body metabolic process, ketone metabolic process, lipid droplet formation, lipid metabolic process, lipoprotein metabolic process, lipoprotein transport, liver development, long-chain fatty acid import into cell, long-chain fatty acid metabolic process, long-chain fatty acid transport, macrophage differentiation, membrane lipid catabolic process, monoacylglycerol metabolic process, multicellular organism growth, phospholipid metabolic process, positive regulation of fatty acid beta-oxidation, protein secretion, reduction of food intake in response to dietary excess, response to cholesterol, response to fatty acid, response to food, response to lipid, response to nutrient, response to oxidative stress, response to peptide, response to starvation, response to tetrachloromethane, response to xenobiotic stimulus, retinol metabolic process, smooth muscle tissue development, triglyceride biosynthetic process, triglyceride homeostasis, triglyceride metabolic process, unsaturated fatty acid biosynthetic process, very-low-density lipoprotein particle clearance, vesicle budding from membrane, xenobiotic transport; MF: antioxidant activity, bile acid binding, binding, cholesterol binding, chromatin binding, fatty acid binding, heterocyclic compound binding, lipid binding, long-chain fatty acid transmembrane transporter activity, long-chain fatty acyl-CoA binding, oleic acid binding, phospholipid binding, sterol binding; CC: EMC complex, apical cortex, cytoplasm, cytosol, endoplasmic reticulum, membrane, nucleoplasm, nucleus, peroxisomal matrix, protein-containing complex
Pathways: Alcoholic liver disease - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Fat digestion and absorption - Mus musculus (mouse), Heme degradation, Metabolism, Metabolism of lipids, Metabolism of porphyrins, PPAR signaling pathway - Mus musculus (mouse), Regulation of lipid metabolism by PPARalpha, Triglyceride catabolism, Triglyceride metabolism
UniProt: P12710
Entrez ID: 14080
|
Does Knockout of Cpd in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Cpd
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cpd (carboxypeptidase D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: peptide metabolic process, protein processing, proteolysis; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, protein phosphatase 2A binding, protein-containing complex binding, zinc ion binding; CC: extracellular space, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, trans-Golgi network
Pathways: Golgi Associated Vesicle Biogenesis, Membrane Trafficking, RHO GTPase cycle, RND1 GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: O89001
Entrez ID: 12874
|
Does Knockout of Chac2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Chac2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Chac2 (ChaC, cation transport regulator 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutathione catabolic process; MF: glutathione specific gamma-glutamylcyclotransferase activity, lyase activity; CC: cytoplasm, cytosol
Pathways: Biological oxidations, Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Glutathione synthesis and recycling, Metabolism, Phase II - Conjugation of compounds
UniProt: Q9CQG1
Entrez ID: 68044
|
Does Knockout of 4921504E06Rik in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
4921504E06Rik
|
cell cycle progression
|
breast epithelium
|
Gene: 4921504E06Rik (RIKEN cDNA 4921504E06 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8CET2
Entrez ID: 70909
|
Does Knockout of Cypt2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Cypt2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cypt2 (cysteine-rich perinuclear theca 2)
Type: protein-coding
Summary: cysteine-rich perinuclear theca 2
Gene Ontology:
Pathways:
UniProt: Q8CH23, Q6P924, A0A9L6KE70
Entrez ID: 245566
|
Does Knockout of Otulin in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Otulin
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Otulin (OTU deubiquitinase with linear linkage specificity)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, angiogenesis, immune system process, innate immune response, negative regulation of NF-kappaB transcription factor activity, negative regulation of inflammatory response, nucleotide-binding oligomerization domain containing 2 signaling pathway, protein linear deubiquitination, proteolysis, regulation of canonical Wnt signaling pathway, regulation of tumor necrosis factor-mediated signaling pathway, sprouting angiogenesis; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: LUBAC complex, cytoplasm
Pathways: Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes
UniProt: Q3UCV8
Entrez ID: 432940
|
Does Knockout of Mrps16 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 1
| 2,474
|
Knockout
|
Mrps16
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Mrps16 (mitochondrial ribosomal protein S16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: cytosol, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CPX7
Entrez ID: 66242
|
Does Knockout of Triml2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Triml2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Triml2 (tripartite motif family-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: innate immune response, response to retinoic acid; MF: identical protein binding, ubiquitin protein ligase activity
Pathways:
UniProt: A0A1B0GSQ3, E9PW10
Entrez ID: 622117
|
Does Knockout of Nkain2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Nkain2
|
response to virus
|
Microglial Cell Line
|
Gene: Nkain2 (Na+/K+ transporting ATPase interacting 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q4PNJ2
Entrez ID: 432450
|
Does Knockout of Atic in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Atic
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atic (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase)
Type: protein-coding
Summary: Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Acts upstream of or within cellular response to interleukin-7. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, animal organ regeneration, brainstem development, cellular response to interleukin-7, cerebellum development, cerebral cortex development, dihydrofolate metabolic process, purine nucleotide biosynthetic process, tetrahydrofolate biosynthetic process; MF: IMP cyclohydrolase activity, catalytic activity, hydrolase activity, phosphoribosylaminoimidazolecarboxamide formyltransferase activity, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion, plasma membrane
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, One carbon pool by folate - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis, inosine-5,-phosphate biosynthesis II
UniProt: Q9CWJ9
Entrez ID: 108147
|
Does Knockout of Ppm1d in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Ppm1d
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Ppm1d (protein phosphatase 1D magnesium-dependent, delta isoform)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, DNA methylation-dependent constitutive heterochromatin formation, G2/M transition of mitotic cell cycle, cellular response to starvation, negative regulation of gene expression, epigenetic, regulation of intracellular signal transduction, response to bacterium; MF: cation binding, hydrolase activity, metal ion binding, mitogen-activated protein kinase binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Transcriptional regulation by RUNX2, p53 signaling pathway - Mus musculus (mouse)
UniProt: Q9QZ67
Entrez ID: 53892
|
Does Knockout of Rab3gap2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rab3gap2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rab3gap2 (RAB3 GTPase activating protein subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of protein localization to endoplasmic reticulum membrane, macroautophagy, positive regulation of autophagosome assembly, positive regulation of endoplasmic reticulum tubular network organization, positive regulation of protein lipidation, regulation of GTPase activity, synaptic signaling; MF: GTPase activator activity, enzyme regulator activity, guanyl-nucleotide exchange factor activity, protein binding, small GTPase binding; CC: autophagosome, cytoplasm, cytosol, endoplasmic reticulum, plasma membrane, presynaptic membrane, protein-containing complex
Pathways: COPI-independent Golgi-to-ER retrograde traffic, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q8BMG7
Entrez ID: 98732
|
Does Knockout of Cfap53 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Cfap53
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Cfap53 (cilia and flagella associated protein 53)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell projection organization, cerebrospinal fluid circulation, cilium assembly, cilium movement, determination of left/right symmetry, epithelial cilium movement involved in determination of left/right asymmetry, establishment of localization in cell, flagellated sperm motility, manchette assembly, protein localization to motile cilium, sperm flagellum assembly, spermatogenesis; MF: molecular_function, protein binding; CC: 9+0 motile cilium, 9+2 motile cilium, axonemal A tubule inner sheath, axonemal microtubule, axoneme, cell projection, centriolar satellite, ciliary transition zone, cilium, cytoplasm, cytoskeleton, extracellular region, glial cell projection, manchette, motile cilium, polymeric cytoskeletal fiber, sperm flagellum, spindle pole
Pathways:
UniProt: Q9D439
Entrez ID: 74453
|
Does Knockout of Ankrd37 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Ankrd37
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ankrd37 (ankyrin repeat domain 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, male germ cell nucleus, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q569N2
Entrez ID: 654824
|
Does Knockout of Ndufa2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ndufa2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ndufa2 (NADH:ubiquinone oxidoreductase subunit A2)
Type: protein-coding
Summary: This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. The human ortholog of this gene has been characterized, and its structure and redox potential is reported to be similar to that of thioredoxins. It may be involved in regulating complex I activity or assembly via assistance in redox processes. In humans, mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. A pseudogene of this gene is located on chromosome 5. [provided by RefSeq, May 2013].
Gene Ontology: BP: aerobic respiration, blastocyst hatching, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQ75
Entrez ID: 17991
|
Does Knockout of Tmem35a in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Tmem35a
|
phagocytosis
|
macrophage
|
Gene: Tmem35a (transmembrane protein 35A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chaperone-mediated protein complex assembly, positive regulation of protein localization to cell surface; MF: acetylcholine receptor regulator activity, protein binding; CC: cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, peroxisomal membrane, peroxisome
Pathways:
UniProt: Q9D328
Entrez ID: 67564
|
Does Knockout of Trub2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Trub2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Trub2 (TruB pseudouridine (psi) synthase family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, RNA processing, mRNA processing, mRNA pseudouridine synthesis, positive regulation of mitochondrial translation, pseudouridine synthesis, tRNA processing; MF: RNA binding, isomerase activity, pseudouridine synthase activity, tRNA pseudouridine(55) synthase activity; CC: mitochondrial matrix, mitochondrion, ribonucleoprotein granule
Pathways:
UniProt: Q91WG3
Entrez ID: 227682
|
Does Knockout of Tgfb2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Tgfb2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Tgfb2 (transforming growth factor, beta 2)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Mice lacking a functional copy of this gene display developmental defects in multiple organs and perinatal lethality. Heterozygous mutant mice exhibit aortic root aneurysm. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: animal organ morphogenesis, ascending aorta morphogenesis, atrial septum morphogenesis, atrial septum primum morphogenesis, atrioventricular valve morphogenesis, axon guidance, blood vessel development, blood vessel remodeling, cardiac epithelial to mesenchymal transition, cardiac left ventricle morphogenesis, cardiac muscle cell proliferation, cardiac right ventricle morphogenesis, cardioblast differentiation, cartilage condensation, cell migration, cell morphogenesis, cell-cell junction organization, collagen fibril organization, cranial skeletal system development, dopamine biosynthetic process, embryo development ending in birth or egg hatching, embryonic digestive tract development, embryonic limb morphogenesis, embryonic neurocranium morphogenesis, endocardial cushion fusion, endocardial cushion morphogenesis, epithelial cell differentiation, epithelial to mesenchymal transition, extracellular matrix organization, extrinsic apoptotic signaling pathway, eye development, face morphogenesis, glial cell migration, hair follicle development, hair follicle morphogenesis, heart development, heart morphogenesis, heart valve morphogenesis, hemopoiesis, inner ear development, kidney development, male gonad development, membranous septum morphogenesis, muscle organ development, negative regulation of Ras protein signal transduction, negative regulation of angiogenesis, negative regulation of apoptotic process, negative regulation of cartilage development, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation, negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation, negative regulation of gene expression, negative regulation of keratinocyte differentiation, negative regulation of macrophage cytokine production, negative regulation of release of sequestered calcium ion into cytosol, neural retina development, neural tube closure, neuron development, neuron fate commitment, neutrophil chemotaxis, outflow tract morphogenesis, outflow tract septum morphogenesis, pericyte cell differentiation, pharyngeal arch artery morphogenesis, positive regulation of GTP binding, positive regulation of Notch signaling pathway, positive regulation of SMAD protein signal transduction, positive regulation of activation-induced cell death of T cells, positive regulation of apoptotic process, positive regulation of cardiac epithelial to mesenchymal transition, positive regulation of cardioblast differentiation, positive regulation of cell adhesion mediated by integrin, positive regulation of cell cycle, positive regulation of cell division, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of epithelial cell migration, positive regulation of epithelial to mesenchymal transition, positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation, positive regulation of extracellular matrix disassembly, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of gene expression, positive regulation of heart contraction, positive regulation of immune response, positive regulation of integrin biosynthetic process, positive regulation of miRNA transcription, positive regulation of neuron apoptotic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to nucleus, positive regulation of protein secretion, positive regulation of stress-activated MAPK cascade, positive regulation of timing of catagen, pulmonary valve morphogenesis, regulation of actin cytoskeleton organization, regulation of apoptotic process, regulation of apoptotic process involved in outflow tract morphogenesis, regulation of cell population proliferation, regulation of extracellular matrix organization, regulation of timing of catagen, regulation of transforming growth factor beta2 production, response to estrogen, response to hypoxia, response to progesterone, response to wounding, salivary gland morphogenesis, secondary palate development, sensory organ development, signaling, skeletal system development, somatic stem cell division, striated muscle tissue development, substantia propria of cornea development, transforming growth factor beta receptor signaling pathway, tube development, uterus development, ventricular septum morphogenesis, ventricular trabecula myocardium morphogenesis, wound healing; MF: amyloid-beta binding, cytokine activity, growth factor activity, identical protein binding, protein binding, protein homodimerization activity, protein-containing complex binding, signaling receptor binding, transforming growth factor beta receptor binding, type II transforming growth factor beta receptor binding, type III transforming growth factor beta receptor binding; CC: axon, basement membrane, cell surface, endosome, extracellular matrix, extracellular region, extracellular space, neuronal cell body, secretory granule, trans-Golgi network
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Elastic fibre formation, Extracellular matrix organization, FoxO signaling pathway - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Malaria - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Molecules associated with elastic fibres, Osteoclast differentiation - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , Proteoglycans in cancer - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Response to elevated platelet cytosolic Ca2+, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by TGFBR3, TGF-beta receptor signaling activates SMADs, TGF-beta signaling pathway - Mus musculus (mouse), TGFBR3 regulates TGF-beta signaling, Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: P27090
Entrez ID: 21808
|
Does Knockout of Fam110a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Fam110a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fam110a (family with sequence similarity 110, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, mitotic spindle organization; CC: cell cortex, cellular_component, centrosome, cytoplasm, cytoskeleton, cytosol, nucleus, spindle microtubule, spindle pole
Pathways:
UniProt: Q8R184
Entrez ID: 73847
|
Does Knockout of Ykt6 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Ykt6
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ykt6 (YKT6 v-SNARE homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, membrane fusion, protein transport, retrograde transport, endosome to Golgi, vesicle docking involved in exocytosis, vesicle targeting, vesicle-mediated transport; MF: SNAP receptor activity, protein-cysteine S-palmitoyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, SNARE complex, apical dendrite, basal dendrite, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, endoplasmic reticulum, endosome, membrane, mitochondrion, neuronal cell body, plasma membrane
Pathways: Asparagine N-linked glycosylation, CDC42 GTPase cycle, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAC1 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOG GTPase cycle, SNARE interactions in vesicular transport - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9CQW1
Entrez ID: 56418
|
Does Knockout of Elovl1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Elovl1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Elovl1 (ELOVL fatty acid elongase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, establishment of skin barrier, fatty acid biosynthetic process, fatty acid elongation, monounsaturated fatty acid, fatty acid elongation, polyunsaturated fatty acid, fatty acid elongation, saturated fatty acid, fatty acid metabolic process, lipid biosynthetic process, lipid metabolic process, long-chain fatty-acyl-CoA biosynthetic process, sphingolipid biosynthetic process, unsaturated fatty acid biosynthetic process, very long-chain fatty acid biosynthetic process; MF: fatty acid elongase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Linoleic acid (LA) metabolism, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs, alpha-linolenic (omega3) and linoleic (omega6) acid metabolism, alpha-linolenic acid (ALA) metabolism
UniProt: Q9JLJ5
Entrez ID: 54325
|
Does Knockout of Pcsk1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Pcsk1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pcsk1 (proprotein convertase subtilisin/kexin type 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: insulin processing, peptide biosynthetic process, peptide hormone processing, positive regulation of protein secretion, protein autoprocessing, protein processing, proteolysis; MF: endopeptidase activity, hydrolase activity, identical protein binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: axon terminus, cytoplasmic vesicle, dendrite, endoplasmic reticulum lumen, extracellular space, membrane, neuron projection, neuronal cell body, perikaryon, perinuclear region of cytoplasm, secretory granule, secretory granule lumen, trans-Golgi network, transport vesicle
Pathways: Metabolism of proteins, Peptide hormone biosynthesis, Peptide hormone metabolism, Synthesis, secretion, and deacylation of Ghrelin
UniProt: P63239
Entrez ID: 18548
|
Does Knockout of Rph3al in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Rph3al
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rph3al (rabphilin 3A-like (without C2 domains))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent activation of synaptic vesicle fusion, establishment of localization in cell, exocytosis, glucose homeostasis, intracellular protein transport, negative regulation of G protein-coupled receptor signaling pathway, positive regulation of calcium ion-dependent exocytosis, positive regulation of insulin secretion, positive regulation of protein secretion, regulation of calcium ion-dependent exocytosis, response to xenobiotic stimulus; MF: LIM domain binding, metal ion binding, protein binding, small GTPase binding, zinc ion binding; CC: cytoplasm, cytoplasmic vesicle, membrane, presynapse, secretory granule, synapse, transport vesicle membrane
Pathways:
UniProt: Q768S4
Entrez ID: 380714
|
Does Knockout of Rbm48 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Rbm48
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rbm48 (RNA binding motif protein 48)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing; MF: RNA binding, molecular_function, nucleic acid binding; CC: nucleoplasm, spliceosomal complex
Pathways:
UniProt: Q8K2X2
Entrez ID: 269623
|
Does Knockout of Stard6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Stard6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Stard6 (StAR related lipid transfer domain containing 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lipid transport; MF: cholesterol binding, lipid binding
Pathways: Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Pregnenolone biosynthesis
UniProt: P59096
Entrez ID: 170461
|
Does Knockout of Polr3gl in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Polr3gl
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Polr3gl (polymerase (RNA) III (DNA directed) polypeptide G like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transcription by RNA polymerase III; CC: RNA polymerase III complex, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: Q8R0C0
Entrez ID: 69870
|
Does Knockout of Lsm5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Lsm5
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Lsm5 (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA catabolic process, mRNA processing, mRNA splicing, via spliceosome, response to bacterium; MF: RNA binding, protein binding, protein heterodimerization activity; CC: Lsm1-7-Pat1 complex, Lsm2-8 complex, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: P62322
Entrez ID: 66373
|
Does Knockout of Thoc2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Thoc2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Thoc2 (THO complex 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, blastocyst development, cell morphogenesis, generation of neurons, mRNA export from nucleus, mRNA processing, mRNA transport, negative regulation of neuron projection development, neuron development, poly(A)+ mRNA export from nucleus, regulation of gene expression, regulation of mRNA export from nucleus, stem cell division; MF: RNA binding, mRNA binding, protein binding; CC: THO complex, THO complex part of transcription export complex, chromosome, telomeric region, cytoplasm, nuclear speck, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: B1AZI6
Entrez ID: 331401
|
Does Knockout of Ugt8a in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Ugt8a
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Ugt8a (UDP galactosyltransferase 8A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoskeleton organization, galactosylceramide biosynthetic process, glycolipid biosynthetic process, lipid metabolic process, myelination, neuron projection morphogenesis, paranodal junction assembly, protein localization to paranode region of axon, response to immobilization stress, sphingolipid metabolic process; MF: N-acylsphingosine galactosyltransferase activity, UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity, UDP-glycosyltransferase activity, ceramide glucosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: endoplasmic reticulum, membrane
Pathways: Ether lipid metabolism - Mus musculus (mouse), Glycosphingolipid biosynthesis, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse)
UniProt: Q64676
Entrez ID: 22239
|
Does Knockout of Eif3m in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Eif3m
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eif3m (eukaryotic translation initiation factor 3, subunit M)
Type: protein-coding
Summary: Enables translation initiation factor binding activity. Acts upstream of or within translation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in several structures, including central nervous system; liver; metanephros; thymus primordium; and upper jaw tooth. Orthologous to human EIF3M (eukaryotic translation initiation factor 3 subunit M). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation; MF: translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q99JX4
Entrez ID: 98221
|
Does Knockout of Msl1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Msl1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Msl1 (male specific lethal 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of DNA-templated transcription; MF: protein binding, protein-macromolecule adaptor activity; CC: MSL complex, nuclear speck, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q6PDM1
Entrez ID: 74026
|
Does Knockout of Prmt7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Prmt7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Prmt7 (protein arginine N-methyltransferase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, chromatin organization, chromatin remodeling, genomic imprinting, methylation, regulation of DNA-templated transcription, spliceosomal snRNP assembly; MF: S-adenosylmethionine-dependent methyltransferase activity, histone H4 methyltransferase activity, histone H4R3 methyltransferase activity, histone binding, histone methyltransferase activity, methyltransferase activity, protein binding, protein-arginine N-methyltransferase activity, protein-arginine omega-N monomethyltransferase activity, protein-arginine omega-N symmetric methyltransferase activity, ribonucleoprotein complex binding, transferase activity; CC: cytoplasm, cytosol, fibrillar center, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, RMTs methylate histone arginines
UniProt: Q922X9
Entrez ID: 214572
|
Does Knockout of Twf1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Twf1
|
cell cycle progression
|
breast epithelium
|
Gene: Twf1 (twinfilin actin binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament depolymerization, barbed-end actin filament capping, negative regulation of actin filament polymerization, positive regulation of cardiac muscle hypertrophy, positive regulation of neuron projection development, regulation of lamellipodium assembly; MF: ATP binding, actin binding, actin filament binding, actin monomer binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein tyrosine kinase activity, protein-containing complex binding; CC: actin cytoskeleton, actin filament, cell-cell junction, cytoplasm, cytoskeleton, cytosol, filopodium, myofibril, perinuclear region of cytoplasm, ruffle membrane
Pathways: RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q91YR1
Entrez ID: 19230
|
Does Knockout of Rcan1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Rcan1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rcan1 (regulator of calcineurin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcineurin-NFAT signaling cascade, calcium-mediated signaling, locomotion involved in locomotory behavior, negative regulation of calcineurin-NFAT signaling cascade, negative regulation of smooth muscle cell differentiation, response to estrogen, response to ischemia, response to mechanical stimulus, response to oxidative stress, response to stress, short-term memory, skeletal muscle fiber development, skeletal muscle tissue development; MF: calcium-dependent protein serine/threonine phosphatase regulator activity, identical protein binding, nucleic acid binding, protein binding, protein phosphatase inhibitor activity; CC: cytoplasm, nucleus
Pathways: Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: Q9JHG6
Entrez ID: 54720
|
Does Knockout of Rps15 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Rps15
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Rps15 (ribosomal protein S15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, liver regeneration, positive regulation of signal transduction by p53 class mediator, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus, translation; MF: MDM2/MDM4 family protein binding, RNA binding, protein binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleoplasm, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62843
Entrez ID: 20054
|
Does Knockout of Rpl32 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Rpl32
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rpl32 (ribosomal protein L32)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to dexamethasone stimulus, cytoplasmic translation, liver regeneration, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62911
Entrez ID: 19951
|
Does Knockout of Uimc1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Uimc1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Uimc1 (ubiquitin interaction motif containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, chromatin organization, double-strand break repair, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, negative regulation of DNA-templated transcription, positive regulation of DNA repair, regulation of DNA repair, response to ionizing radiation; MF: DNA binding, K63-linked polyubiquitin modification-dependent protein binding, histone binding, metal ion binding, nuclear retinoid X receptor binding, ubiquitin-modified histone reader activity, zinc ion binding; CC: BRCA1-A complex, nuclear body, nucleoplasm, nucleus, site of double-strand break
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, G2/M DNA damage checkpoint, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Processing of DNA double-strand break ends, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q5U5Q9
Entrez ID: 20184
|
Does Knockout of Capn13 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Capn13
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Capn13 (calpain 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity
Pathways: Degradation of the extracellular matrix, Extracellular matrix organization
UniProt: Q3UW68
Entrez ID: 381122
|
Does Knockout of Ropn1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Ropn1
|
response to virus
|
Microglial Cell Line
|
Gene: Ropn1 (ropporin, rhophilin associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium organization, flagellated sperm motility, protein localization to cilium, sperm capacitation; MF: identical protein binding, protein binding, protein heterodimerization activity; CC: cell projection, cilium, cytoplasm, cytosol, motile cilium, sperm cytoplasmic droplet, sperm flagellum, sperm principal piece
Pathways:
UniProt: Q9ESG2
Entrez ID: 76378
|
Does Knockout of Ubxn7 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Ubxn7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ubxn7 (UBX domain protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA polymerase II-specific DNA-binding transcription factor binding, ubiquitin binding, ubiquitin protein ligase binding; CC: VCP-NPL4-UFD1 AAA ATPase complex, nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q6P5G6
Entrez ID: 224111
|
Does Knockout of Exoc8 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Exoc8
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Exoc8 (exocyst complex component 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, endosome organization, exocytosis, extracellular matrix disassembly, intracellular protein localization, membrane fission, mitotic cytokinesis, protein transport, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; MF: phosphatidylinositol binding, small GTPase binding; CC: cell leading edge, cell periphery, cell projection, cytoplasm, exocyst, growth cone, late endosome, perinuclear region of cytoplasm, plasma membrane
Pathways: Cargo trafficking to the periciliary membrane, Cilium Assembly, Insulin processing, Metabolism of proteins, Organelle biogenesis and maintenance, Peptide hormone metabolism, VxPx cargo-targeting to cilium
UniProt: Q6PGF7
Entrez ID: 102058
|
Does Knockout of Xpo5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Xpo5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Xpo5 (exportin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, intracellular protein transport, pre-miRNA export from nucleus, protein export from nucleus, protein transport, regulatory ncRNA-mediated gene silencing; MF: RISC complex binding, RNA binding, mRNA binding, nuclear export signal receptor activity, pre-miRNA binding, small GTPase binding, tRNA binding; CC: RISC complex, RNA nuclear export complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q924C1
Entrez ID: 72322
|
Does Knockout of Ptrh2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Ptrh2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Ptrh2 (peptidyl-tRNA hydrolase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of anoikis, negative regulation of gene expression, positive regulation of anoikis; MF: hydrolase activity, peptidyl-tRNA hydrolase activity; CC: cytosol, membrane, mitochondrial outer membrane, mitochondrion
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q8R2Y8
Entrez ID: 217057
|
Does Knockout of Zbtb45 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Zbtb45
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Zbtb45 (zinc finger and BTB domain containing 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, nervous system development, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q52KG4
Entrez ID: 232879
|
Does Knockout of Esco2 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,536
|
Knockout
|
Esco2
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Esco2 (establishment of sister chromatid cohesion N-acetyltransferase 2)
Type: protein-coding
Summary: Enables L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Acts upstream of or within several processes, including double-strand break repair; hematopoietic progenitor cell differentiation; and protein localization to chromatin. Located in chromocenter and chromosome. Is expressed in several structures, including alimentary system; brain; gonad; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Roberts syndrome and lung adenocarcinoma. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromosome segregation, double-strand break repair, hematopoietic progenitor cell differentiation, mitotic sister chromatid cohesion, protein localization to chromatin, regulation of DNA replication; MF: L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, acetyltransferase activity, acyltransferase activity, metal ion binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: Golgi apparatus, XY body, cell junction, chromatin, chromocenter, chromosome, nucleoplasm, nucleus, pericentric heterochromatin, site of double-strand break
Pathways: Cell Cycle, Cell Cycle, Mitotic, Establishment of Sister Chromatid Cohesion, S Phase
UniProt: Q8CIB9
Entrez ID: 71988
|
Does Knockout of Ranbp6 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Ranbp6
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Ranbp6 (RAN binding protein 6)
Type: protein-coding
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Is active in synapse. Orthologous to human RANBP6 (RAN binding protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: protein import into nucleus, protein transport; MF: nuclear import signal receptor activity, nuclear localization sequence binding; CC: cytoplasm, nucleus, synapse
Pathways:
UniProt: Q8BIV3
Entrez ID: 240614
|
Does Knockout of Rabl6 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Rabl6
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Rabl6 (RAB, member RAS oncogene family-like 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, nucleotide binding; CC: centriolar satellite, centrosome, ciliary basal body, cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q5U3K5
Entrez ID: 227624
|
Does Knockout of Dnajc27 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Dnajc27
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Dnajc27 (DnaJ heat shock protein family (Hsp40) member C27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, positive regulation of ERK1 and ERK2 cascade; MF: GTP binding, GTPase activity, nucleotide binding, protein binding; CC: mitochondrion, nucleus
Pathways:
UniProt: Q8CFP6
Entrez ID: 217378
|
Does Knockout of Rrm1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Rrm1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Rrm1 (ribonucleotide reductase M1)
Type: protein-coding
Summary: Enables disordered domain specific binding activity; purine nucleotide binding activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in several processes, including nucleoside phosphate metabolic process; positive regulation of G0 to G1 transition; and protein heterotetramerization. Part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: 2'-deoxyribonucleotide biosynthetic process, DNA repair, DNA synthesis involved in DNA repair, cell proliferation in forebrain, deoxyribonucleotide biosynthetic process, male gonad development, mitochondrial DNA replication, positive regulation of G0 to G1 transition, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of G2/M transition of mitotic cell cycle, protein heterotetramerization, pyrimidine nucleobase metabolic process, response to ionizing radiation, retina development in camera-type eye, ribonucleoside diphosphate metabolic process; MF: ATP binding, catalytic activity, disordered domain specific binding, identical protein binding, nucleotide binding, oxidoreductase activity, protein binding, purine nucleotide binding, ribonucleoside-diphosphate reductase activity, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; CC: cell projection, centriolar satellite, ciliary basal body, cytoplasm, cytosol, mitochondrion, neuronal cell body, nuclear envelope, ribonucleoside-diphosphate reductase complex
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Glutathione metabolism - Mus musculus (mouse), Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), adenosine nucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis I
UniProt: P07742
Entrez ID: 20133
|
Does Knockout of Ccdc92 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ccdc92
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ccdc92 (coiled-coil domain containing 92)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in innate immune response. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in centriole. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and sensory organ. Orthologous to human CCDC92 (coiled-coil domain containing 92). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, immune system process, innate immune response; MF: identical protein binding, molecular_function; CC: centriole, centrosome, cytoplasm, cytoskeleton, nucleoplasm
Pathways:
UniProt: Q8VDN4
Entrez ID: 215707
|
Does Knockout of Cyp2c65 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Cyp2c65
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cyp2c65 (cytochrome P450, family 2, subfamily c, polypeptide 65)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epoxygenase P450 pathway, estrogen metabolic process, icosanoid biosynthetic process, lipid hydroxylation, organic acid metabolic process, oxidative demethylation, retinoic acid metabolic process, steroid metabolic process, xenobiotic catabolic process, xenobiotic metabolic process; MF: arachidonate epoxygenase activity, arachidonate monooxygenase activity, caffeine oxidase activity, estrogen 16-alpha-hydroxylase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, retinoic acid 4-hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, plasma membrane
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Aspirin ADME, Biological oxidations, Biosynthesis of DHA-derived SPMs, Biosynthesis of maresin-like SPMs, Biosynthesis of maresins, Biosynthesis of specialized proresolving mediators (SPMs), CYP2E1 reactions, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Cytochrome P450 - arranged by substrate type, Drug ADME, Fatty acid metabolism, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phase I - Functionalization of compounds, Retinol metabolism - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE), Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET), Xenobiotics, bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q9CVC8, Q148B1
Entrez ID: 72303
|
Does Knockout of Keap1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Keap1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Keap1 (kelch-like ECH-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to carbohydrate stimulus, cellular response to interleukin-4, cellular response to oxidative stress, in utero embryonic development, negative regulation of gene expression, negative regulation of response to oxidative stress, negative regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein ubiquitination, regulation of DNA-templated transcription, regulation of autophagy, regulation of epidermal cell differentiation, response to oxidative stress, ubiquitin-dependent protein catabolic process; MF: RNA polymerase II-specific DNA-binding transcription factor binding, disordered domain specific binding, identical protein binding, protein binding, transcription regulator inhibitor activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, actin filament, adherens junction, centriolar satellite, cytoplasm, cytosol, endoplasmic reticulum, focal adhesion, inclusion body, midbody, nucleoplasm, nucleus, protein-containing complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, Deubiquitination, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Immune System, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9Z2X8
Entrez ID: 50868
|
Does Knockout of Neurl2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Neurl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Neurl2 (neuralized E3 ubiquitin protein ligase 2)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within sarcomere organization. Located in muscle tendon junction. Part of VCB complex. Is expressed in forebrain; gonad; metanephros; and submandibular gland. Orthologous to human NEURL2 (neuralized E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: intracellular signal transduction, myofibril assembly, protein ubiquitination, sarcomere organization; MF: protein binding, ubiquitin protein ligase activity; CC: VCB complex, cytoplasm, muscle tendon junction
Pathways:
UniProt: A2A5J5
Entrez ID: 415115
|
Does Knockout of Trim30a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Trim30a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Trim30a (tripartite motif-containing 30A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, autophagy, host-mediated suppression of symbiont invasion, innate immune response, negative regulation of NLRP3 inflammasome complex assembly, negative regulation of interleukin-6 production, negative regulation of reactive oxygen species metabolic process, negative regulation of toll-like receptor signaling pathway, negative regulation of tumor necrosis factor production, positive regulation of MAPK cascade, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein catabolic process, positive regulation of viral entry into host cell, protein K63-linked ubiquitination, protein autoubiquitination, regulation of gene expression, regulation of lipopolysaccharide-mediated signaling pathway, regulation of protein localization, regulation of viral entry into host cell, response to bacterium, suppression of viral release by host; MF: DNA binding, identical protein binding, metal ion binding, pattern recognition receptor activity, protein homodimerization activity, protein kinase binding, protein-macromolecule adaptor activity, transcription coactivator activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: P-body, cytoplasm, nucleus, omegasome
Pathways:
UniProt: P15533
Entrez ID: 20128
|
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