prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Ppme1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ppme1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ppme1 (protein phosphatase methylesterase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carboxylic ester hydrolase activity, catalytic activity, hydrolase activity, lncRNA binding, protein kinase binding, protein methylesterase activity, protein phosphatase 2A binding, protein phosphatase binding, protein phosphatase inhibitor activity
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Transition, Mitotic G2-G2/M phases
UniProt: Q8BVQ5
Entrez ID: 72590
|
Does Knockout of Rps5 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Rps5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rps5 (ribosomal protein S5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, regulation of translational fidelity, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, mRNA binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P97461
Entrez ID: 20103
|
Does Knockout of Klk12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Klk12
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Klk12 (kallikrein related-peptidase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein maturation, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular space, secretory granule
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: B2RVZ0
Entrez ID: 69511
|
Does Knockout of Pramel6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Pramel6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pramel6 (PRAME like 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q810Y9
Entrez ID: 347711
|
Does Knockout of Retn in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Retn
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Retn (resistin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fat cell differentiation, negative regulation of feeding behavior, positive regulation of collagen metabolic process, positive regulation of progesterone secretion, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of synaptic transmission, response to insulin, signal transduction; CC: extracellular region, extracellular space
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q99P87
Entrez ID: 57264
|
Does Knockout of Wdr93 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Wdr93
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Wdr93 (WD repeat domain 93)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q402B2
Entrez ID: 626359
|
Does Knockout of Crygf in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Crygf
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Crygf (crystallin, gamma F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to reactive oxygen species, eye development, lens development in camera-type eye, visual perception; MF: structural constituent of eye lens
Pathways:
UniProt: Q9CXV3
Entrez ID: 12969
|
Does Knockout of Elk1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Elk1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Elk1 (ELK1, member of ETS oncogene family)
Type: protein-coding
Summary: This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene may produce multiple isoforms by the use of alternative translational start codons. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: cell differentiation, cellular response to gamma radiation, cellular response to lipid, cellular response to testosterone stimulus, gene expression, hippocampal neuron apoptotic process, liver development, lung development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to ethanol, response to fibroblast growth factor, response to light stimulus; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, double-stranded DNA binding, mediator complex binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription regulator activator activity, transcription regulator inhibitor activity; CC: axon terminus, dendrite, mitochondrial membrane, neuronal cell body, nucleoplasm, nucleus
Pathways: Endometrial cancer - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse)
UniProt: P41969
Entrez ID: 13712
|
Does Knockout of Sptlc2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Sptlc2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sptlc2 (serine palmitoyltransferase, long chain base subunit 2)
Type: protein-coding
Summary: This gene encodes a long chain base subunit of serine palmitoyltransferase. The enzyme, serine palmitoyltransferase, consists of two different subunits, and is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. A mutant allele of this gene in mice is used as a model for the human disease 'Susceptibilty to Psoriasis 1'. Mutations in the human gene are associated with hereditary sensory neuropathy type I. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: adipose tissue development, ceramide biosynthetic process, lipid metabolic process, positive regulation of lipophagy, sphinganine biosynthetic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingomyelin biosynthetic process, sphingosine biosynthetic process; MF: acyltransferase activity, pyridoxal phosphate binding, serine C-palmitoyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion, serine palmitoyltransferase complex
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), ceramide biosynthesis
UniProt: P97363
Entrez ID: 20773
|
Does Knockout of 2510009E07Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
2510009E07Rik
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: 2510009E07Rik (RIKEN cDNA 2510009E07 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian behavior, nervous system development
Pathways:
UniProt: Q6GQU0
Entrez ID: 72190
|
Does Knockout of Id2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Id2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Id2 (inhibitor of DNA binding 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Peyer's patch development, adipose tissue development, adult locomotory behavior, bundle of His development, cell development, cell differentiation, cell maturation, cell morphogenesis involved in neuron differentiation, cellular response to lithium ion, cellular senescence, circadian regulation of gene expression, circadian rhythm, embryonic digestive tract morphogenesis, endodermal digestive tract morphogenesis, entrainment of circadian clock, entrainment of circadian clock by photoperiod, enucleate erythrocyte differentiation, epithelial cell differentiation involved in mammary gland alveolus development, heart development, leukocyte differentiation, locomotor rhythm, lymph node development, mammary gland alveolus development, mammary gland epithelial cell proliferation, membranous septum morphogenesis, metanephros development, natural killer cell differentiation, negative regulation of B cell differentiation, negative regulation of DNA-templated transcription, negative regulation of core promoter binding, negative regulation of dopaminergic neuron differentiation, negative regulation of gene expression, negative regulation of muscle cell differentiation, negative regulation of oligodendrocyte differentiation, negative regulation of osteoblast differentiation, negative regulation of transcription by RNA polymerase II, neuron differentiation, neuron fate commitment, olfactory bulb development, oligodendrocyte development, positive regulation of DNA-templated transcription, positive regulation of astrocyte differentiation, positive regulation of blood pressure, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of erythrocyte differentiation, positive regulation of fat cell differentiation, positive regulation of gene expression, positive regulation of macrophage differentiation, positive regulation of smooth muscle cell proliferation, regulation of G1/S transition of mitotic cell cycle, regulation of circadian rhythm, regulation of gene expression, regulation of lipid metabolic process, regulation of neural precursor cell proliferation, regulation of neuron differentiation, regulation of transcription by RNA polymerase II, rhythmic process, thigmotaxis, white fat cell differentiation; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, protein dimerization activity, transcription corepressor activity, transcription regulator inhibitor activity, transmembrane transporter binding; CC: chromatin, cytoplasm, cytosol, euchromatin, nucleus, protein-containing complex
Pathways: Hippo signaling pathway - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P41136
Entrez ID: 15902
|
Does Knockout of Acsf3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Acsf3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Acsf3 (acyl-CoA synthetase family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, malonate catabolic process; MF: ATP binding, CoA-ligase activity, ligase activity, malonyl-CoA synthetase activity, nucleotide binding, very long-chain fatty acid-CoA ligase activity; CC: mitochondrion
Pathways: Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs, Valine, leucine and isoleucine degradation - Mus musculus (mouse)
UniProt: Q3URE1
Entrez ID: 257633
|
Does Knockout of Rcan3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Rcan3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rcan3 (regulator of calcineurin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-mediated signaling; MF: calcium-dependent protein serine/threonine phosphatase regulator activity, nucleic acid binding, phosphatase binding, troponin I binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9JKK0
Entrez ID: 53902
|
Does Knockout of Fbxw9 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Fbxw9
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fbxw9 (F-box and WD-40 domain protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q6PAS7, F8VPX2
Entrez ID: 68628
|
Does Knockout of Pth2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Pth2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pth2 (parathyroid hormone 2)
Type: protein-coding
Summary: This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. Mice lacking the encoded protein display increased fear and anxiety after exposure to stressful events, and decreased sensitivity to pain. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: cAMP biosynthetic process, neuropeptide signaling pathway
Pathways: Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q91W27
Entrez ID: 114640
|
Does Knockout of Cd302 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Cd302
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cd302 (CD302 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phagocytosis; MF: carbohydrate binding, signaling receptor activity; CC: cell cortex, cell projection, cytoplasm, filopodium, membrane, microvillus
Pathways:
UniProt: Q9DCG2
Entrez ID: 66205
|
Does Knockout of Klhl11 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Klhl11
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Klhl11 (kelch-like 11)
Type: protein-coding
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL11 (kelch like family member 11). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, cellular_component, cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q8CE33
Entrez ID: 217194
|
Does Knockout of Gm11544 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Gm11544
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gm11544 (predicted gene 11544)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Nin in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Nin
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Nin (ninein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole-centriole cohesion, centrosome localization, centrosome-templated microtubule nucleation, collateral sprouting, corpus callosum morphogenesis, corticospinal tract morphogenesis, intracellular protein localization, microtubule anchoring at centrosome, mitotic spindle organization, negative regulation of protein localization to centrosome, positive regulation of axonogenesis, positive regulation of neuron differentiation; MF: GTP binding, calcium ion binding, microtubule minus-end binding, nucleotide binding, protein binding; CC: apical part of cell, axon, axonal growth cone, centriolar subdistal appendage, centriole, centrosome, ciliary basal body, ciliary transition fiber, cytoplasm, cytoplasmic microtubule, cytoskeleton, cytosol, dendrite, microtubule, mitotic spindle, mitotic spindle pole, nucleolus, nucleoplasm, pericentriolar material, plasma membrane, spindle pole
Pathways:
UniProt: Q61043
Entrez ID: 18080
|
Does Knockout of Nrgn in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Nrgn
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Nrgn (neurogranin)
Type: protein-coding
Summary: Enables calmodulin binding activity. Predicted to be involved in positive regulation of long-term synaptic potentiation and postsynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in several cellular components, including dendritic spine head; neuronal cell body; and trans-Golgi network transport vesicle membrane. Predicted to be active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and stomach. Orthologous to human NRGN (neurogranin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: associative learning, intracellular signal transduction, positive regulation of long-term synaptic potentiation, postsynaptic modulation of chemical synaptic transmission, telencephalon development; MF: calmodulin binding, phosphatidic acid binding, phosphatidylinositol-3,4,5-trisphosphate binding; CC: axon, cell projection, cytoplasm, dendrite, dendritic spine, dendritic spine head, glutamatergic synapse, mitochondrial membrane, neuronal cell body, postsynapse, postsynaptic membrane, synapse, trans-Golgi network transport vesicle membrane
Pathways:
UniProt: P60761
Entrez ID: 64011
|
Does Knockout of Zbtb7c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Zbtb7c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zbtb7c (zinc finger and BTB domain containing 7C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell population proliferation, positive regulation of fat cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: Q8VCZ7
Entrez ID: 207259
|
Does Knockout of Pigl in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Pigl
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pigl (phosphatidylinositol glycan anchor biosynthesis, class L)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, lipid metabolic process; MF: N-acetylglucosaminylphosphatidylinositol deacetylase activity, hydrolase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Synthesis of glycosylphosphatidylinositol (GPI)
UniProt: Q5SX19
Entrez ID: 327942
|
Does Knockout of Mrps21 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Mrps21
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrps21 (mitochondrial ribosomal protein S21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: P58059
Entrez ID: 66292
|
Does Knockout of Sytl3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Sytl3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Sytl3 (synaptotagmin-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, intracellular protein transport; MF: calcium-dependent phospholipid binding, neurexin family protein binding, phospholipid binding, protein binding, small GTPase binding, zinc ion binding; CC: endomembrane system, exocytic vesicle, membrane, plasma membrane
Pathways:
UniProt: Q99N48
Entrez ID: 83672
|
Does Knockout of Pde4dip in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Pde4dip
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pde4dip (phosphodiesterase 4D interacting protein (myomegalin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: astral microtubule organization, centrosome cycle, positive regulation of microtubule nucleation, protein-containing complex assembly, regulation of Golgi organization; MF: enzyme binding, molecular adaptor activity, protein binding; CC: Golgi apparatus, centrosome, cortical microtubule plus-end, cytoplasm, cytoskeleton, microtubule organizing center, myofibril, nucleus
Pathways:
UniProt: Q80YT7
Entrez ID: 83679
|
Does Knockout of Krt78 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Krt78
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Krt78 (keratin 78)
Type: protein-coding
Summary: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Is active in cornified envelope. Orthologous to human KRT78 (keratin 78). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: intermediate filament organization, keratinization; CC: cornified envelope, intermediate filament, keratin filament
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q6IFT3, E9Q0F0
Entrez ID: 332131
|
Does Knockout of Rhox3e in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Rhox3e
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Rhox3e (reproductive homeobox 3E)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: V9GX94, Q4TU90, V9GXY5, V9GXK5, V9GWU0, V9GXD0, V9GXQ1
Entrez ID: 100135657
|
Does Knockout of Pdp2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Pdp2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pdp2 (pyruvate dehydrogenase phosphatase catalytic subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity, cation binding, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Regulation of pyruvate dehydrogenase (PDH) complex, Regulation of pyruvate metabolism
UniProt: Q504M2
Entrez ID: 382051
|
Does Knockout of Pnma1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Pnma1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pnma1 (paraneoplastic antigen MA1)
Type: protein-coding
Summary: Predicted to be involved in inflammatory response to antigenic stimulus. Predicted to be located in cytoplasm and nucleolus. Orthologous to human PNMA1 (PNMA family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: inflammatory response to antigenic stimulus; CC: cytoplasm, nucleolus, nucleus
Pathways:
UniProt: Q8C1C8
Entrez ID: 70481
|
Does Knockout of Trmt1l in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Trmt1l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Trmt1l (tRNA methyltransferase 1 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult behavior, adult locomotory behavior, methylation, tRNA N2-guanine methylation, tRNA processing; MF: RNA binding, metal ion binding, methyltransferase activity, tRNA (guanine(27)-N2)-dimethyltransferase activity, tRNA (guanine) methyltransferase activity, tRNA binding, transferase activity, zinc ion binding; CC: nucleolus, nucleus
Pathways:
UniProt: A2RSY6
Entrez ID: 98685
|
Does Knockout of Serpina10 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Serpina10
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Serpina10 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the large serpin family of proteins, and is also known as serpin PZ-dependent protease inhibitor (ZPI or PZI). This protein is thought to play an important role in the regulation of coagulation. It directly inhibits factor XIa, and also inhibits factor Xa in the presence of calcium, phospholipids, and protein Z (PZ). Deficiencies in this gene lead to an increase in thrombosis. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: blood coagulation, hemostasis, liver regeneration; MF: heparin binding, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q8R121
Entrez ID: 217847
|
Does Knockout of Lsm4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Lsm4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Lsm4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P-body assembly, RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, spliceosomal snRNP assembly; MF: PH domain binding, RNA binding, U6 snRNA binding; CC: Lsm2-8 complex, P-body, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, cytosol, membrane, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q9QXA5
Entrez ID: 50783
|
Does Knockout of Kif21b in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Kif21b
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Kif21b (kinesin family member 21B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, corpus callosum development, microtubule-based movement, regulation of postsynaptic membrane neurotransmitter receptor levels, retrograde dendritic transport; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, nucleotide binding; CC: axon, cell projection, cytoplasm, cytoplasmic vesicle, cytoskeleton, dendrite, dendrite cytoplasm, glutamatergic synapse, growth cone, kinesin complex, microtubule, postsynaptic endosome
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9QXL1
Entrez ID: 16565
|
Does Knockout of Cystm1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Cystm1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cystm1 (cysteine-rich transmembrane module containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q8K353
Entrez ID: 66060
|
Does Knockout of Mrpl20 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Mrpl20
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mrpl20 (mitochondrial ribosomal protein L20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CQL4
Entrez ID: 66448
|
Does Knockout of Stxbp3 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Stxbp3
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Stxbp3 (syntaxin binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cellular response to type II interferon, exocytosis, insulin secretion, intracellular glucose homeostasis, intracellular protein transport, negative regulation of D-glucose import, negative regulation of calcium ion-dependent exocytosis, negative regulation of transport, neutrophil degranulation, platelet aggregation, presynaptic dense core vesicle exocytosis, protein to membrane docking, protein transport, regulation of biological quality, response to insulin, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: protein binding, protein-containing complex binding, syntaxin binding, syntaxin-1 binding; CC: apical plasma membrane, basolateral plasma membrane, cytoplasm, cytosol, membrane, phagocytic vesicle, plasma membrane, platelet alpha granule, presynapse, secretory granule, specific granule, tertiary granule
Pathways:
UniProt: Q60770
Entrez ID: 20912
|
Does Knockout of Fbxw2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Fbxw2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fbxw2 (F-box and WD-40 domain protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9QUH1, Q8BS25, Q9CPQ6, Q8CCH8, A2AUF9, A2AUG1
Entrez ID: 30050
|
Does Knockout of Paxip1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,551
|
Knockout
|
Paxip1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Paxip1 (PAX interacting (with transcription-activation domain) protein 1)
Type: protein-coding
Summary: This gene encodes a nuclear-localized protein that contains six BRCT1 (C-terminal of breast cancer susceptibility protein) domains. The encoded protein is involved in the repair of DNA double-strand breaks and is necessary for progression through cell division. The protein also functions in the regulation of transcription by recruiting histone methyltransferases to gene promoters bound by the sequence-specific transcription factor paired box protein 2 (Pax2). [provided by RefSeq, Mar 2013].
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA recombination, DNA repair, adipose tissue development, chorion development, chromatin remodeling, endothelial cell migration, negative regulation of DNA-binding transcription factor activity, positive regulation of isotype switching, positive regulation of isotype switching to IgG isotypes, positive regulation of protein ubiquitination, positive regulation of transcription initiation by RNA polymerase II, regulation of cell cycle G2/M phase transition, response to ionizing radiation, vasculogenesis; CC: MLL3/4 complex, chromosome, histone methyltransferase complex, nuclear matrix, nucleoplasm, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Nonhomologous End-Joining (NHEJ)
UniProt: Q6NZQ4
Entrez ID: 55982
|
Does Knockout of Zfp131 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Zfp131
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zfp131 (zinc finger protein 131)
Type: protein-coding
Summary: This gene encodes a member of the BTB/POZ family of transcription factors. This protein has been found to act as a transcriptional activator and may regulate estrogen receptor signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: intermediate filament cytoskeleton, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors
UniProt: Q8K3J5
Entrez ID: 72465
|
Does Knockout of Prmt9 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Prmt9
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Prmt9 (protein arginine methyltransferase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, mRNA processing, methylation, regulation of DNA-templated transcription; MF: histone methyltransferase activity, methyltransferase activity, protein-arginine N-methyltransferase activity, protein-arginine omega-N symmetric methyltransferase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q3U3W5
Entrez ID: 102182
|
Does Knockout of Txlnb in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Txlnb
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Txlnb (taxilin beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, syntaxin binding; CC: cytoplasm
Pathways:
UniProt: Q8VBT1
Entrez ID: 378431
|
Does Knockout of Ints6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ints6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ints6 (integrator complex subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, protein localization to chromatin, snRNA 3'-end processing, snRNA processing, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: protein-macromolecule adaptor activity; CC: INTAC complex, actin cytoskeleton, chromatin, chromosome, integrator complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q6PCM2
Entrez ID: 18130
|
Does Knockout of Pcnx2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Pcnx2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pcnx2 (pecanex homolog 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q5DU28
Entrez ID: 270109
|
Does Knockout of Sapcd2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Sapcd2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sapcd2 (suppressor APC domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, establishment of mitotic spindle orientation, negative regulation of protein localization to cell cortex, positive regulation of cell population proliferation, regulation of establishment of planar polarity, symmetric cell division; CC: anchoring junction, apical cortex, apical junction complex, apical plasma membrane, bicellular tight junction, cell cortex, cytoplasm, cytosol, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q9D818
Entrez ID: 72080
|
Does Knockout of Cd274 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Cd274
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cd274 (CD274 antigen)
Type: protein-coding
Summary: The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: T cell costimulation, TRIF-dependent toll-like receptor signaling pathway, adaptive immune response, cell surface receptor signaling pathway, cellular response to lipopolysaccharide, immune response, immune system process, negative regulation of CD4-positive, alpha-beta T cell proliferation, negative regulation of CD8-positive, alpha-beta T cell activation, negative regulation of T cell activation, negative regulation of T cell mediated immune response to tumor cell, negative regulation of T cell proliferation, negative regulation of activated T cell proliferation, negative regulation of interleukin-10 production, negative regulation of tumor necrosis factor superfamily cytokine production, negative regulation of type II interferon production, positive regulation of DNA-templated transcription, positive regulation of T cell proliferation, positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process, positive regulation of cell migration, positive regulation of interleukin-10 production, response to cytokine, signal transduction; MF: protein binding, receptor ligand activity, transcription coactivator activity; CC: actin cytoskeleton, cell surface, early endosome membrane, endosome, external side of plasma membrane, extracellular exosome, membrane, nucleoplasm, plasma membrane, recycling endosome membrane
Pathways: AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Cell adhesion molecules - Mus musculus (mouse), Co-inhibition by PD-1, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Immune System, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PD-L1(CD274) glycosylation and translocation to plasma membrane, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SPOP-mediated proteasomal degradation of PD-L1(CD274)
UniProt: Q9EP73
Entrez ID: 60533
|
Does Knockout of Lyrm4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Lyrm4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lyrm4 (LYR motif containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: [2Fe-2S] cluster assembly, [4Fe-4S] cluster assembly, iron-sulfur cluster assembly; MF: molecular_function, protein homodimerization activity, structural molecule activity; CC: L-cysteine desulfurase complex, iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrion, nuclear body, nucleus
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Complex III assembly, Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Respiratory electron transport
UniProt: Q8K215
Entrez ID: 380840
|
Does Knockout of Rack1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rack1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rack1 (receptor for activated C kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to glucose stimulus, cellular response to growth factor stimulus, gastrulation, intracellular protein localization, intracellular signal transduction, negative regulation of Wnt signaling pathway, negative regulation of cell growth, negative regulation of gene expression, negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide, negative regulation of phagocytosis, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of smoothened signaling pathway, negative regulation of translation, negative regulation of translational frameshifting, pigmentation, positive regulation of GTPase activity, positive regulation of Golgi to plasma membrane protein transport, positive regulation of amide metabolic process, positive regulation of apoptotic process, positive regulation of cell migration, positive regulation of gastrulation, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of lipid metabolic process, positive regulation of mitochondrial depolarization, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein phosphorylation, positive regulation of protein-containing complex assembly, protein ubiquitination, regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of cell cycle, regulation of cell division, regulation of establishment of cell polarity, regulation of membrane lipid metabolic process, regulation of protein localization, regulation of protein localization to plasma membrane, regulation of translation, rescue of stalled ribosome, rhythmic process, translation, tumor necrosis factor-mediated signaling pathway; MF: BH3 domain binding, SH2 domain binding, cyclin binding, cysteine-type endopeptidase activator activity involved in apoptotic process, enzyme activator activity, enzyme binding, identical protein binding, ion channel inhibitor activity, protein binding, protein homodimerization activity, protein kinase C binding, protein phosphatase binding, protein serine/threonine kinase inhibitor activity, protein tyrosine kinase inhibitor activity, receptor tyrosine kinase binding, ribosome binding, signaling adaptor activity, signaling receptor activity, translation regulator activity; CC: IRE1-RACK1-PP2A complex, cell body, cell projection, cytoplasm, cytosol, dendrite, membrane, midbody, mitochondrion, neuron projection, neuronal cell body, nucleoplasm, nucleus, perikaryon, perinuclear region of cytoplasm, phagocytic cup, plasma membrane, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Death Receptor Signaling, Degradation of CDH1, Measles - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of TNFR1 signaling, Signal Transduction, TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR1-mediated ceramide production
UniProt: P68040
Entrez ID: 14694
|
Does Knockout of B3gnt2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
B3gnt2
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: B3gnt2 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2)
Type: protein-coding
Summary: Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. Acts upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and sensory perception of smell. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and nose. Orthologous to human B3GNT2 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: axon guidance, cellular response to leukemia inhibitory factor, poly-N-acetyllactosamine biosynthetic process, protein O-linked glycosylation, protein glycosylation, sensory perception of smell; MF: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosaminoglycan biosynthesis - keratan sulfate - Mus musculus (mouse), Glycosaminoglycan metabolism, Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification
UniProt: Q9Z222
Entrez ID: 53625
|
Does Knockout of Ndrg1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Ndrg1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Ndrg1 (N-myc downstream regulated gene 1)
Type: protein-coding
Summary: Predicted to enable cadherin binding activity; small GTPase binding activity; and tubulin binding activity. Involved in negative regulation of cell population proliferation and peripheral nervous system myelin maintenance. Acts upstream of or within mast cell activation. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Charcot-Marie-Tooth disease type 4D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, cellular response to hypoxia, mast cell activation, negative regulation of cell population proliferation, peripheral nervous system myelin maintenance, signal transduction; MF: cadherin binding, gamma-tubulin binding, microtubule binding, nickel cation binding, small GTPase binding; CC: adherens junction, centrosome, cytoplasm, cytoskeleton, cytosol, membrane, microtubule, microtubule cytoskeleton, myelin sheath, nucleus, perinuclear region of cytoplasm, plasma membrane, recycling endosome membrane
Pathways:
UniProt: Q62433
Entrez ID: 17988
|
Does Knockout of Tfrc in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,287
|
Knockout
|
Tfrc
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tfrc (transferrin receptor)
Type: protein-coding
Summary: This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: acute-phase response, cell surface receptor signaling pathway, cellular response to iron ion, cellular response to leukemia inhibitory factor, cellular response to xenobiotic stimulus, endocytosis, intracellular iron ion homeostasis, intracellular signal transduction, iron ion transmembrane transport, iron ion transport, multicellular organismal-level iron ion homeostasis, negative regulation of apoptotic process, negative regulation of mitochondrial fusion, osteoclast differentiation, positive regulation of B cell proliferation, positive regulation of T cell proliferation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of gene expression, positive regulation of isotype switching, positive regulation of protein localization to nucleus, positive regulation of protein-containing complex assembly, receptor internalization, receptor-mediated endocytosis, regulation of postsynaptic membrane neurotransmitter receptor levels, response to copper ion, response to hypoxia, response to iron ion, response to manganese ion, response to nutrient, response to retinoic acid, transferrin transport; MF: Hsp70 protein binding, double-stranded RNA binding, identical protein binding, iron ion transmembrane transporter activity, protein binding, protein homodimerization activity, protein kinase binding, protein-containing complex binding, protein-folding chaperone binding, transferrin receptor activity; CC: HFE-transferrin receptor complex, basolateral plasma membrane, cell surface, clathrin-coated pit, cytoplasmic vesicle, early endosome, endosome, endosome membrane, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, glutamatergic synapse, melanosome, membrane, perinuclear region of cytoplasm, plasma membrane, postsynapse, postsynaptic recycling endosome membrane, recycling endosome, recycling endosome membrane
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Endocytosis - Mus musculus (mouse), Ferroptosis - Mus musculus (mouse), Golgi Associated Vesicle Biogenesis, HIF-1 signaling pathway - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Iron uptake and transport, Membrane Trafficking, Phagosome - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOG GTPase cycle, RHOH GTPase cycle, RHOQ GTPase cycle, RND1 GTPase cycle, RND2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transferrin endocytosis and recycling, Transport of small molecules, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q62351
Entrez ID: 22042
|
Does Knockout of Ufsp2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Ufsp2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ufsp2 (UFM1-specific peptidase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of proteolysis involved in protein catabolic process, proteolysis, regulation of intracellular estrogen receptor signaling pathway, regulation of type II interferon production, rescue of stalled ribosome, ribosome disassembly; MF: cysteine-type peptidase activity, deUFMylase activity, hydrolase activity, peptidase activity; CC: cytoplasm, endoplasmic reticulum, nucleus
Pathways:
UniProt: Q99K23
Entrez ID: 192169
|
Does Knockout of Shq1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Shq1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Shq1 (SHQ1 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: box H/ACA snoRNP assembly, positive regulation of TORC1 signaling, protein-RNA complex assembly, regulation of androgen receptor signaling pathway; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q7TMX5
Entrez ID: 72171
|
Does Knockout of Slc30a6 in Microglial Cell Line causally result in protein/peptide distribution?
| 1
| 1,585
|
Knockout
|
Slc30a6
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Slc30a6 (solute carrier family 30 (zinc transporter), member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to endosome transport, monoatomic cation transport, monoatomic ion transport, regulation of zinc ion transport, transmembrane transport, zinc ion import into Golgi lumen, zinc ion transport; MF: monoatomic cation transmembrane transporter activity, zinc ion transmembrane transporter activity; CC: Golgi apparatus, cytosol, membrane, mitochondrion, trans-Golgi network membrane
Pathways:
UniProt: Q8BJM5
Entrez ID: 210148
|
Does Knockout of Scx in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Scx
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Scx (scleraxis scleraxis bHLH transcription factor)
Type: protein-coding
Summary: This gene encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation. The encoded protein is expressed during embryonic development of tendons and ligaments. The gene product regulates collagen type I gene expression in cardiac fibroblasts and myofibroblasts, and it may play a role in myocardial remodeling. The protein is expressed in the scar area of the adult heart following myocardial infarction. [provided by RefSeq, Feb 2010].
Gene Ontology: BP: BMP signaling pathway, DNA-templated transcription, Sertoli cell development, Sertoli cell differentiation, cartilage development, cell differentiation, cellular response to BMP stimulus, cellular response to cAMP, cellular response to follicle-stimulating hormone stimulus, cellular response to mechanical stimulus, cellular response to transforming growth factor beta stimulus, chondrocyte differentiation, collagen fibril organization, deltoid tuberosity development, developmental process, embryonic skeletal system development, endochondral ossification, face morphogenesis, heart valve formation, heart valve morphogenesis, mesoderm formation, muscle structure development, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of gene expression, positive regulation of DNA-templated transcription, positive regulation of cartilage development, positive regulation of cell population proliferation, positive regulation of collagen biosynthetic process, positive regulation of gastrulation, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of cartilage development, regulation of transcription by RNA polymerase II, sclerotome development, skeletal muscle cell differentiation, tendon cell differentiation, tendon development, tendon formation, tissue homeostasis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, bHLH transcription factor binding, cis-regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity, sequence-specific DNA binding; CC: nucleus, transcription regulator complex
Pathways:
UniProt: Q64124
Entrez ID: 20289
|
Does Knockout of Sorl1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Sorl1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Sorl1 (sortilin-related receptor, LDLR class A repeats-containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive thermogenesis, amyloid-beta formation, cell migration, diet induced thermogenesis, endocytosis, endosome to plasma membrane protein transport, insulin receptor recycling, negative regulation of BMP signaling pathway, negative regulation of amyloid precursor protein catabolic process, negative regulation of amyloid-beta formation, negative regulation of neurofibrillary tangle assembly, negative regulation of neurogenesis, negative regulation of protein-containing complex assembly, negative regulation of triglyceride catabolic process, neuropeptide signaling pathway, positive regulation of ER to Golgi vesicle-mediated transport, positive regulation of adipose tissue development, positive regulation of early endosome to recycling endosome transport, positive regulation of endocytic recycling, positive regulation of glial cell-derived neurotrophic factor production, positive regulation of insulin receptor signaling pathway, positive regulation of protein catabolic process, positive regulation of protein exit from endoplasmic reticulum, positive regulation of protein localization to early endosome, post-Golgi vesicle-mediated transport, protein localization to Golgi apparatus, protein retention in Golgi apparatus, protein targeting, protein targeting to lysosome, receptor-mediated endocytosis, regulation of smooth muscle cell migration, retrograde transport, endosome to Golgi; MF: amyloid-beta binding, aspartic-type endopeptidase inhibitor activity, low-density lipoprotein particle binding, neuropeptide binding, protein binding, protein transporter activity, small GTPase binding, transmembrane signaling receptor activity; CC: Golgi apparatus, Golgi cisterna, Golgi membrane, cell surface, cytoplasmic vesicle, cytosol, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, extracellular region, extracellular space, membrane, multivesicular body, multivesicular body membrane, neuronal cell body, nuclear envelope lumen, perinuclear region of cytoplasm, perinucleolar compartment, plasma membrane, recycling endosome, recycling endosome membrane, trans-Golgi network, transport vesicle membrane
Pathways:
UniProt: O88307
Entrez ID: 20660
|
Does Knockout of Mettl21a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Mettl21a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mettl21a (methyltransferase 21A, HSPA lysine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, negative regulation of protein folding, protein methylation; MF: ATPase binding, Hsp70 protein binding, heat shock protein binding, methyltransferase activity, protein methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Protein methylation
UniProt: Q9CQL0
Entrez ID: 67099
|
Does Knockout of Fancl in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,553
|
Knockout
|
Fancl
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Fancl (Fanconi anemia, complementation group L)
Type: protein-coding
Summary: This gene encodes the complementation group L subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes. The FA complex is necessary for protection against DNA damage. This gene product, an E3 ubiquitin ligase, catalyzes and is required for the monoubiquitination of the protein encoded by the Fanconi anemia, complementation group D2 gene, a critical step in the FA pathway (PMID: 12973351, 21229326). In mouse, mutations of this E3 ubiquitin ligase gene can lead to infertility in adult males and females, and a deletion of this gene can cause embryonic lethality in some genetic backgrounds. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: DNA damage response, DNA repair, gamete generation, interstrand cross-link repair, protein monoubiquitination, protein ubiquitination, regulation of cell population proliferation; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: Fanconi anaemia nuclear complex, chromatin, cytoplasm, nuclear body, nuclear envelope, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9CR14
Entrez ID: 67030
|
Does Knockout of Lgi4 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Lgi4
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Lgi4 (leucine-rich repeat LGI family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell development, adult locomotory behavior, glial cell development, glial cell proliferation, gliogenesis, myelination, myelination in peripheral nervous system, neuron maturation, regulation of myelination; CC: extracellular region, extracellular space
Pathways: Developmental Biology, LGI-ADAM interactions
UniProt: Q8K1S1
Entrez ID: 243914
|
Does Knockout of Vmn1r7 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Vmn1r7
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Vmn1r7 (vomeronasal 1 receptor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: E9Q8T0
Entrez ID: 434016
|
Does Knockout of Dimt1 in Lung Cancer Cell Line causally result in tumorigenicity?
| 0
| 1,089
|
Knockout
|
Dimt1
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Dimt1 (DIM1 rRNA methyltransferase and ribosome maturation factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, positive regulation of rRNA processing, rRNA methylation, rRNA modification, rRNA processing, ribosomal small subunit biogenesis; MF: 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity, RNA binding, methyltransferase activity, rRNA (adenine-N6,N6-)-dimethyltransferase activity, transferase activity; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways:
UniProt: Q9D0D4
Entrez ID: 66254
|
Does Knockout of Haus2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Haus2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Haus2 (HAUS augmin-like complex, subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome cycle, microtubule nucleation, microtubule organizing center organization, spindle assembly; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, microtubule, mitotic spindle microtubule, spindle, spindle microtubule
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9CQS9
Entrez ID: 66296
|
Does Knockout of Havcr1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Havcr1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Havcr1 (hepatitis A virus cellular receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phagocytosis, engulfment, positive regulation of mast cell activation, response to lipopolysaccharide, response to wounding, symbiont entry into host cell; MF: phosphatidylserine binding, protein binding, virus receptor activity; CC: apical plasma membrane, brush border, cell surface, extracellular space, membrane, motile cilium, phagocytic vesicle, plasma membrane
Pathways:
UniProt: Q5QNS5
Entrez ID: 171283
|
Does Knockout of Abra in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Abra
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Abra (actin-binding Rho activating protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, positive regulation of DNA-templated transcription, positive regulation of Rho protein signal transduction, positive regulation of transcription by RNA polymerase II, protein import into nucleus, protein transport; MF: actin binding; CC: actin cytoskeleton, cytoplasm, cytoskeleton, myofibril, plasma membrane, sarcomere
Pathways:
UniProt: Q8BUZ1
Entrez ID: 223513
|
Does Knockout of Bmpr1b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Bmpr1b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Bmpr1b (bone morphogenetic protein receptor, type 1B)
Type: protein-coding
Summary: This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: BMP signaling pathway, MAPK cascade, bone development, camera-type eye development, cartilage condensation, cartilage development, cell differentiation, cell surface receptor protein serine/threonine kinase signaling pathway, cellular response to BMP stimulus, cellular response to growth factor stimulus, central nervous system neuron differentiation, chondrocyte development, chondrocyte differentiation, dorsal/ventral pattern formation, endochondral bone morphogenesis, estrogen biosynthetic process, eye development, inflammatory response, negative regulation of chondrocyte proliferation, osteoblast differentiation, ovarian cumulus expansion, ovulation cycle, positive regulation of bone mineralization, positive regulation of cartilage development, positive regulation of chondrocyte differentiation, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of gene expression, positive regulation of osteoblast differentiation, positive regulation of transcription by RNA polymerase II, proteoglycan biosynthetic process, retina development in camera-type eye, retinal ganglion cell axon guidance, transforming growth factor beta receptor signaling pathway; MF: ATP binding, BMP binding, BMP receptor activity, SMAD binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, transforming growth factor beta receptor activity, transforming growth factor beta receptor activity, type I, transmembrane receptor protein serine/threonine kinase activity, transmembrane signaling receptor activity; CC: dendrite, membrane, neuronal cell body, plasma membrane, receptor complex
Pathways: Axon guidance - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by BMP, Signaling by TGFB family members, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: P36898
Entrez ID: 12167
|
Does Knockout of Rnf13 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Rnf13
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rnf13 (ring finger protein 13)
Type: protein-coding
Summary: This gene encodes a member of the PA-TM-RING family of proteins that contain a protease associated (PA) domain and a RING finger domain separated by a transmembrane (TM) domain. The encoded protein is an E3 ubiquitin ligase localized to the endosomal-lysosomal vesicles and inner nuclear membrane. Mice lacking the encoded protein have impaired learning abilities associated with a decreased synaptic vesicle density and dysregulated SNARE complex assembly. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on the X chromosome. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: positive regulation of JNK cascade, protein autoubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: JUN kinase binding, metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, nuclear inner membrane, nucleoplasm, nucleus
Pathways:
UniProt: O54965
Entrez ID: 24017
|
Does Knockout of Alg2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Alg2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Alg2 (ALG2 alpha-1,3/1,6-mannosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein glycosylation; MF: GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity, GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity, alpha-1,3-mannosyltransferase activity, glycosyltransferase activity, transferase activity; CC: cytoplasmic side of endoplasmic reticulum membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q9DBE8
Entrez ID: 56737
|
Does Knockout of Rars2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Rars2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Rars2 (arginyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: Predicted to enable arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation and mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; respiratory system; submandibular gland primordium; and urinary system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: arginyl-tRNA aminoacylation, gene expression, mitochondrial translation, tRNA aminoacylation for protein translation, tRNA metabolic process, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, arginine-tRNA ligase activity, ligase activity, nucleotide binding; CC: cytoplasm, membrane, mitochondrial membrane, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q3U186
Entrez ID: 109093
|
Does Knockout of Psma2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Psma2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Psma2 (proteasome subunit alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, response to virus, ubiquitin-dependent protein catabolic process; CC: P-body, cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P49722
Entrez ID: 19166
|
Does Knockout of Vwa3a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Vwa3a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Vwa3a (von Willebrand factor A domain containing 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UVV9
Entrez ID: 233813
|
Does Knockout of Rnf8 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Rnf8
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rnf8 (ring finger protein 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, cell division, chromatin organization, double-strand break repair, double-strand break repair via nonhomologous end joining, epigenetic regulation of gene expression, isotype switching, negative regulation of transcription elongation by RNA polymerase II, positive regulation of DNA repair, positive regulation of double-strand break repair via homologous recombination, protein K48-linked ubiquitination, protein K6-linked ubiquitination, protein K63-linked ubiquitination, protein autoubiquitination, protein localization to site of double-strand break, protein ubiquitination, response to ionizing radiation, signal transduction in response to DNA damage, sperm DNA condensation, ubiquitin-dependent protein catabolic process; MF: chromatin binding, histone binding, identical protein binding, metal ion binding, protein binding, protein homodimerization activity, transferase activity, ubiquitin binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: chromosome, chromosome, telomeric region, cytoplasm, cytosol, midbody, nucleoplasm, nucleus, site of double-strand break, ubiquitin ligase complex
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, G2/M Checkpoints, G2/M DNA damage checkpoint, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Nonhomologous End-Joining (NHEJ), Processing of DNA double-strand break ends, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q8VC56
Entrez ID: 58230
|
Does Knockout of Rcor2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Rcor2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rcor2 (REST corepressor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: enzyme binding, protein binding, transcription corepressor activity; CC: chromatin, histone deacetylase complex, nucleus, transcription regulator complex
Pathways:
UniProt: Q8C796
Entrez ID: 104383
|
Does Knockout of Pced1b in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Pced1b
|
response to virus
|
Microglial Cell Line
|
Gene: Pced1b (PC-esterase domain containing 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BGX1
Entrez ID: 239647
|
Does Knockout of Podxl in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Podxl
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Podxl (podocalyxin-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell migration, epithelial tube formation, leukocyte migration, negative regulation of cell adhesion, negative regulation of cell-cell adhesion, podocyte development, positive regulation of cell migration, positive regulation of cell-cell adhesion mediated by integrin, regulation of cell-cell adhesion, regulation of microvillus assembly, regulation of synapse assembly; CC: apical plasma membrane, cell body, cell projection, centriolar satellite, cytoplasm, endoplasmic reticulum, extracellular exosome, filopodium, glutamatergic synapse, lamellipodium, membrane, membrane raft, microvillus, microvillus membrane, nucleolus, plasma membrane, presynaptic membrane, ruffle, slit diaphragm
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q9R0M4
Entrez ID: 27205
|
Does Knockout of Sdhb in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Sdhb
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sdhb (succinate dehydrogenase complex, subunit B, iron sulfur (Ip))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, respiratory electron transport chain, succinate metabolic process, tricarboxylic acid cycle; MF: 2 iron, 2 sulfur cluster binding, 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, electron transfer activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, succinate dehydrogenase (quinone) activity, ubiquinone binding; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleoplasm, plasma membrane, respiratory chain complex II (succinate dehydrogenase)
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II, aerobic respiration -- electron donors reaction list
UniProt: Q9CQA3
Entrez ID: 67680
|
Does Knockout of Mir9-1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Mir9-1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mir9-1 (microRNA 9-1)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cellular hyperosmotic salinity response, cellular response to ethanol, cellular response to leukemia inhibitory factor, interneuron axon guidance, long-term synaptic potentiation, miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated post-transcriptional gene silencing, olfactory bulb interneuron differentiation, regulation of gene expression, regulation of neuron differentiation; MF: mRNA 3'-UTR binding, mRNA base-pairing post-transcriptional repressor activity
Pathways: MicroRNAs in cancer - Mus musculus (mouse)
UniProt:
Entrez ID: 387133
|
Does Knockout of Ldb3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ldb3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ldb3 (LIM domain binding 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, heart development, muscle structure development, sarcomere organization; MF: actin binding, cytoskeletal protein binding, enzyme binding, metal ion binding, muscle alpha-actinin binding, protein binding, protein kinase C binding; CC: Z disc, adherens junction, cell projection, cytoplasm, cytoskeleton, filamentous actin, perinuclear region of cytoplasm, pseudopodium, stress fiber
Pathways:
UniProt: Q9JKS4
Entrez ID: 24131
|
Does Knockout of Zmpste24 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Zmpste24
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Zmpste24 (zinc metallopeptidase, STE24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CAAX-box protein processing, CAMKK-AMPK signaling cascade, DNA damage response, DNA repair, adult walking behavior, bone mineralization, calcium ion import into sarcoplasmic reticulum, cardiac conduction, cardiac muscle cell development, cardiac ventricle development, cellular response to gamma radiation, chromatin organization, chromosome organization, determination of adult lifespan, epidermis development, epigenetic regulation of gene expression, growth plate cartilage development, hair follicle development, heart morphogenesis, inflammatory cell apoptotic process, kidney morphogenesis, lipid metabolic process, liver development, maintenance of rDNA, multicellular organism growth, negative regulation of gene expression, negative regulation of miRNA processing, neuromuscular process, nuclear envelope organization, nucleus organization, positive regulation of gene expression, positive regulation of gene expression via chromosomal CpG island demethylation, prenylated protein catabolic process, protein maturation, protein processing, proteolysis, regulation of DNA damage response, signal transduction by p53 class mediator, regulation of DNA-templated transcription, regulation of TOR signaling, regulation of autophagy, regulation of blood circulation, regulation of bone mineralization, regulation of cell shape, regulation of cellular senescence, regulation of defense response to virus, regulation of fibroblast proliferation, regulation of glucose metabolic process, regulation of heart contraction, regulation of hormone metabolic process, regulation of lipid metabolic process, regulation of mitotic cell cycle, regulation of mitotic cell cycle DNA replication, regulation of multicellular organism growth, regulation of stress-activated protein kinase signaling cascade, regulation of termination of RNA polymerase I transcription, regulation of ventricular cardiac muscle cell membrane repolarization, response to DNA damage checkpoint signaling, thymus development, ventricular cardiac muscle tissue development; MF: double-stranded DNA binding, endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity; CC: early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, late endosome membrane, membrane, nuclear envelope, nuclear inner membrane, nucleus, protein-containing complex
Pathways: Terpenoid backbone biosynthesis - Mus musculus (mouse)
UniProt: Q80W54
Entrez ID: 230709
|
Does Knockout of Spidr in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,525
|
Knockout
|
Spidr
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Spidr (scaffolding protein involved in DNA repair)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cellular response to camptothecin, cellular response to hydroxyurea, cellular response to ionizing radiation, double-strand break repair via homologous recombination, positive regulation of double-strand break repair, positive regulation of protein-containing complex assembly, regulation of double-strand break repair via homologous recombination, regulation of establishment of protein localization to chromosome; CC: nuclear chromosome, nucleoplasm, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q8BGX7
Entrez ID: 224008
|
Does Knockout of Wsb2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Wsb2
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Wsb2 (WD repeat and SOCS box-containing 2)
Type: protein-coding
Summary: Predicted to be involved in protein polyubiquitination. Is expressed in several structures, including central nervous system; gonad; lung; stomach; and urinary system. Orthologous to human WSB2 (WD repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, intracellular signal transduction, protein polyubiquitination, protein ubiquitination
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: O54929
Entrez ID: 59043
|
Does Knockout of Gpc1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Gpc1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Gpc1 (glypican 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell differentiation, cell migration, heparan sulfate proteoglycan catabolic process, myelin assembly, negative regulation of fibroblast growth factor receptor signaling pathway, positive regulation of skeletal muscle cell differentiation, regulation of protein localization to membrane, regulation of signal transduction; MF: collagen V binding, copper ion binding, fibroblast growth factor binding, laminin binding; CC: Golgi lumen, cell surface, cytosol, endosome, extracellular matrix, extracellular region, membrane, membrane raft, neuronal cell body, nucleoplasm, plasma membrane, side of membrane, synapse
Pathways: Axon guidance, Cell surface interactions at the vascular wall, Developmental Biology, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glycosaminoglycan metabolism, Glycosaminoglycan-protein linkage region biosynthesis, HS-GAG biosynthesis, HS-GAG degradation, Hemostasis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Nervous system development, Proteoglycans in cancer - Mus musculus (mouse), Retinoid metabolism and transport, Sensory Perception, Signaling by ROBO receptors, Visual phototransduction
UniProt: Q9QZF2
Entrez ID: 14733
|
Does Knockout of Mcoln2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Mcoln2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mcoln2 (mucolipin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, immune system process, innate immune response, iron ion transmembrane transport, macrophage migration, monoatomic ion transmembrane transport, monoatomic ion transport, neutrophil migration, positive regulation of chemokine (C-C motif) ligand 5 production, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of chemokine production, positive regulation of macrophage inflammatory protein 1 alpha production, positive regulation of monocyte chemotactic protein-1 production, protein transport, regulation of chemokine (C-X-C motif) ligand 2 production; MF: NAADP-sensitive calcium-release channel activity, calcium channel activity, identical protein binding, iron ion transmembrane transporter activity, monoatomic cation channel activity, monoatomic cation transmembrane transporter activity; CC: endosome, lysosomal membrane, lysosome, membrane, plasma membrane, recycling endosome, recycling endosome membrane
Pathways: Calcium signaling pathway - Mus musculus (mouse), Ion channel transport, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q8K595
Entrez ID: 68279
|
Does Knockout of Six2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Six2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Six2 (sine oculis-related homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior axis specification, cell fate specification, cell migration, cell population proliferation, chondrocyte differentiation, condensed mesenchymal cell proliferation, embryonic cranial skeleton morphogenesis, embryonic digestive tract morphogenesis, embryonic skeletal system morphogenesis, kidney development, kidney mesenchyme development, mesenchymal cell differentiation, mesenchymal cell differentiation involved in kidney development, mesenchymal cell proliferation, mesenchymal stem cell maintenance involved in nephron morphogenesis, mesenchymal stem cell proliferation, mesenchymal to epithelial transition involved in metanephros morphogenesis, mesodermal cell fate specification, metanephros development, middle ear morphogenesis, negative regulation of epithelial cell differentiation, nephron development, nephron epithelium morphogenesis, nephron morphogenesis, positive regulation of chondrocyte proliferation, positive regulation of transcription by RNA polymerase II, protein import into nucleus, regulation of DNA-templated transcription, regulation of branching involved in ureteric bud morphogenesis, regulation of chondrocyte differentiation, regulation of ossification, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription factor binding; CC: nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q62232
Entrez ID: 20472
|
Does Knockout of 4921517D22Rik in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
4921517D22Rik
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: 4921517D22Rik (RIKEN cDNA 4921517D22 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A286YDE0, Q8CET0
Entrez ID: 70900
|
Does Knockout of Senp3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Senp3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Senp3 (SUMO/sentrin specific peptidase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of double-strand break repair via homologous recombination, protein desumoylation, proteolysis; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deSUMOylase activity, hydrolase activity, peptidase activity, protein binding; CC: MLL1 complex, cytoplasm, nuclear body, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9EP97
Entrez ID: 80886
|
Does Knockout of Tle1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Tle1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tle1 (transducin-like enhancer of split 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of DNA-templated transcription, negative regulation of Wnt signaling pathway, negative regulation of anoikis, negative regulation of canonical NF-kappaB signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of gene expression, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor binding, chromatin binding, identical protein binding, protein binding, transcription corepressor activity; CC: beta-catenin-TCF complex, cytoplasm, cytosol, nucleoplasm, nucleus, transcription regulator complex
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Formation of the beta-catenin:TCF transactivating complex, Negative Regulation of CDH1 Gene Transcription, Notch signaling pathway - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Repression of WNT target genes, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q62440
Entrez ID: 21885
|
Does Knockout of Cs in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Cs
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Cs (citrate synthase)
Type: protein-coding
Summary: The protein encoded by this gene is a central metabolic pathway enzyme, catalyzing the first step of the tricarboxylic acid cycle in which acetyl coenzyme A and oxaloacetate are converted to citrate and coenzyme A. This enzyme is found in nearly all cells capable of oxidative metabolism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: acetyl-CoA metabolic process, carbohydrate metabolic process, citrate metabolic process, oxaloacetate metabolic process, tricarboxylic acid cycle; MF: acyltransferase activity, acyl groups converted into alkyl on transfer, citrate synthase activity, identical protein binding, transferase activity; CC: mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, TCA cycle, TCA cycle variation III (eukaryotic)
UniProt: Q9CZU6
Entrez ID: 12974
|
Does Knockout of Dnm2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Dnm2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dnm2 (dynamin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, Golgi to plasma membrane transport, actin filament bundle organization, aorta development, autophagy, cellular response to dopamine, centrosome cycle, coronary vasculature development, endocytosis, macropinocytosis, membrane tubulation, negative regulation of membrane tubulation, negative regulation of non-motile cilium assembly, negative regulation of transforming growth factor beta receptor signaling pathway, neuron projection morphogenesis, phagocytosis, positive regulation of clathrin-dependent endocytosis, positive regulation of endocytosis, positive regulation of lamellipodium assembly, positive regulation of nitric oxide biosynthetic process, positive regulation of phagocytosis, positive regulation of substrate adhesion-dependent cell spreading, postsynaptic endocytosis, protein polymerization, receptor internalization, receptor-mediated endocytosis, regulation of Golgi organization, regulation of Rac protein signal transduction, regulation of axon extension, stress fiber assembly, synaptic vesicle budding from presynaptic endocytic zone membrane, synaptic vesicle endocytosis, transferrin transport, ventricular septum development, vesicle scission; MF: D2 dopamine receptor binding, GTP binding, GTPase activity, SH3 domain binding, WW domain binding, hydrolase activity, microtubule binding, nitric-oxide synthase binding, nucleotide binding, phosphatidylinositol 3-kinase regulatory subunit binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein kinase binding, protein serine/threonine kinase binding, protein-containing complex binding; CC: Golgi apparatus, Golgi membrane, anchoring junction, cell junction, cell projection, centriole, centrosome, clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endosome, glutamatergic synapse, growth cone, lamellipodium, membrane, microtubule, midbody, neuron projection, perinuclear region of cytoplasm, phagocytic cup, phagocytic vesicle membrane, photoreceptor inner segment, plasma membrane, podosome, postsynaptic density, postsynaptic density, intracellular component, postsynaptic endocytic zone, postsynaptic membrane, presynapse, protein-containing complex, recycling endosome, ruffle membrane, synapse, trans-Golgi network, uropod
Pathways: Adaptive Immune System, Adherens junctions interactions, Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Clathrin-mediated endocytosis, Degradation of CDH1, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Golgi Associated Vesicle Biogenesis, Immune System, Innate Immune System, L1CAM interactions, Lysosome Vesicle Biogenesis, MHC class II antigen presentation, Membrane Trafficking, Metabolism, Metabolism of nitric oxide: NOS3 activation and regulation, NOSTRIN mediated eNOS trafficking, Nervous system development, Phospholipase D signaling pathway - Mus musculus (mouse), Recycling pathway of L1, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Salmonella infection - Mus musculus (mouse), Synaptic vesicle cycle - Mus musculus (mouse), Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Vesicle-mediated transport, cyclic AMP biosynthesis, trans-Golgi Network Vesicle Budding
UniProt: P39054
Entrez ID: 13430
|
Does Knockout of Fndc5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Fndc5
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fndc5 (fibronectin type III domain containing 5)
Type: protein-coding
Summary: This gene encodes a type I transmembrane protein containing fibronectin type III repeat. The encoded transmembrane protein undergoes proteolytic processing to generate a soluble hormone named irisin that is secreted into the bloodstream. The expression of this gene followed by the secretion of irisin from skeletal muscle is induced by exercise. The ectopic expression of the encoded protein in mice causes an elevation of irisin in blood and improves metabolic health. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: positive regulation of brown fat cell differentiation, response to muscle activity, signal transduction; MF: hormone activity, protein binding; CC: endoplasmic reticulum, extracellular region, membrane, peroxisomal membrane, peroxisome, plasma membrane
Pathways:
UniProt: Q8K4Z2
Entrez ID: 384061
|
Does Knockout of Mthfd2l in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Mthfd2l
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mthfd2l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 10-formyltetrahydrofolate metabolic process, amino acid biosynthetic process, carboxylic acid metabolic process, methionine biosynthetic process, one-carbon metabolic process, purine nucleotide biosynthetic process, tetrahydrofolate interconversion; MF: catalytic activity, hydrolase activity, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, oxidoreductase activity; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Metabolism, Metabolism of folate and pterines, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, One carbon pool by folate - Mus musculus (mouse), folate transformations I, folate transformations II (plants)
UniProt: D3YZG8
Entrez ID: 665563
|
Does Knockout of Xrcc6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Xrcc6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Xrcc6 (X-ray repair complementing defective repair in Chinese hamster cells 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, V(D)J recombination, activation of innate immune response, cellular hyperosmotic salinity response, cellular response to X-ray, cellular response to gamma radiation, double-strand break repair, double-strand break repair via classical nonhomologous end joining, double-strand break repair via nonhomologous end joining, immune system process, innate immune response, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of immune system process, positive regulation of lymphocyte differentiation, positive regulation of neurogenesis, positive regulation of transcription by RNA polymerase II, recombinational repair, regulation of smooth muscle cell proliferation, response to ionizing radiation, telomere maintenance; MF: 5'-deoxyribose-5-phosphate lyase activity, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, DNA binding, DNA end binding, DNA helicase activity, catalytic activity, cyclin binding, damaged DNA binding, double-stranded DNA binding, double-stranded telomeric DNA binding, helicase activity, hydrolase activity, lyase activity, nucleotide binding, protein binding, protein-containing complex binding, scaffold protein binding, telomeric DNA binding, transcription cis-regulatory region binding; CC: DNA-dependent protein kinase complex, DNA-dependent protein kinase-DNA ligase 4 complex, Ku70:Ku80 complex, chromosome, cytoplasm, nonhomologous end joining complex, nucleolus, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, transcription regulator complex
Pathways: DNA Double-Strand Break Repair, DNA Repair, Immune System, Innate Immune System, Neutrophil degranulation, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ)
UniProt: P23475
Entrez ID: 14375
|
Does Knockout of Kcnh6 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Kcnh6
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Kcnh6 (potassium voltage-gated channel, subfamily H (eag-related), member 6)
Type: protein-coding
Summary: Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in several processes, including potassium ion transmembrane transport; regulation of heart rate by cardiac conduction; and regulation of ventricular cardiac muscle cell membrane repolarization. Predicted to be active in plasma membrane. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; retina; and skin. Used to study glucose metabolism disease. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: membrane repolarization during cardiac muscle cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, regulation of heart rate by cardiac conduction, regulation of ventricular cardiac muscle cell membrane repolarization, transmembrane transport; MF: inward rectifier potassium channel activity, monoatomic ion channel activity, potassium channel activity, protein-containing complex binding, voltage-gated potassium channel activity; CC: membrane, monoatomic ion channel complex, plasma membrane
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: M0QW64, Q32ME0, B1AR82
Entrez ID: 192775
|
Does Knockout of Phf23 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Phf23
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Phf23 (PHD finger protein 23)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; and limb. Orthologous to human PHF23 (PHD finger protein 23). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: autophagy, negative regulation of autophagosome assembly, negative regulation of autophagosome maturation, positive regulation of protein ubiquitination; MF: metal ion binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8BSN5
Entrez ID: 78246
|
Does Knockout of Tma16 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Tma16
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tma16 (translation machinery associated 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, ribosomal large subunit biogenesis, ribosome biogenesis; MF: molecular_function, preribosome binding; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9CR02
Entrez ID: 66282
|
Does Knockout of Nmb in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Nmb
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nmb (neuromedin B)
Type: protein-coding
Summary: This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in satiety, reproduction and thermoregulation, as well as in stress, fear and other behavioral responses. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: Leydig cell proliferation, antiviral innate immune response, arachidonate secretion, immune system process, innate immune response, negative regulation of hormone secretion, negative regulation of interleukin-6 production, neuropeptide signaling pathway, positive regulation of cell population proliferation, positive regulation of cytosolic calcium ion concentration, positive regulation of hormone secretion, positive regulation of interferon-alpha production, positive regulation of osteoclast proliferation, positive regulation of respiratory gaseous exchange, positive regulation of testosterone secretion, sensory perception of itch, sneeze reflex; MF: neuromedin B receptor binding, neuropeptide hormone activity; CC: cell projection, extracellular region, extracellular space, neuron projection
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q9CR53
Entrez ID: 68039
|
Does Knockout of Mphosph10 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Mphosph10
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mphosph10 (M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein))
Type: protein-coding
Summary: Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in chromosome and nucleolus. Predicted to be part of Mpp10 complex and small-subunit processome. Is expressed in esophagus; lung; pituitary gland; urethra; and vertebral axis musculature. Orthologous to human MPHOSPH10 (M-phase phosphoprotein 10). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; CC: Mpp10 complex, chromosome, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome, sno(s)RNA-containing ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q810V0
Entrez ID: 67973
|
Does Knockout of Pcnt in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Pcnt
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pcnt (pericentrin (kendrin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain morphogenesis, camera-type eye development, cerebellar cortex morphogenesis, cilium assembly, embryonic brain development, embryonic heart tube development, head development, in utero embryonic development, kidney development, limb morphogenesis, microtubule cytoskeleton organization, microtubule nucleation, mitotic spindle organization, multicellular organism growth, negative regulation of apoptotic process, neural precursor cell proliferation, neuron migration, olfactory bulb development, positive regulation of intracellular protein transport, signal transduction, spindle organization, vasculature development; MF: calmodulin binding, molecular adaptor activity, protein binding; CC: centriolar satellite, centriole, centrosome, ciliary basal body, cilium, cis-Golgi network, cytoplasm, cytoskeleton, cytosol, intercellular bridge, microtubule, microtubule organizing center, motile cilium, pericentriolar material
Pathways: AURKA Activation by TPX2, Aggrephagy, Anchoring of the basal body to the plasma membrane, Autophagy, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Macroautophagy, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Selective autophagy
UniProt: P48725
Entrez ID: 18541
|
Does Knockout of Zfhx4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Zfhx4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Zfhx4 (zinc finger homeodomain 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q6P8L4, E9Q5A7, H3BLK8, V9GXP5
Entrez ID: 80892
|
Does Knockout of Aif1l in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Aif1l
|
cell proliferation
|
Regulatory T cell
|
Gene: Aif1l (allograft inflammatory factor 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament bundle assembly, ruffle assembly; MF: actin binding, actin filament binding, calcium ion binding, metal ion binding; CC: actin cytoskeleton, actin filament, cell projection, cytoplasm, cytoskeleton, focal adhesion, lamellipodium, membrane, plasma membrane, protein-containing complex, ruffle membrane
Pathways:
UniProt: Q9EQX4
Entrez ID: 108897
|
Does Knockout of Polr2i in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Polr2i
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Polr2i (polymerase (RNA) II (DNA directed) polypeptide I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription-coupled nucleotide-excision repair; MF: DNA-directed RNA polymerase activity, metal ion binding, nucleic acid binding, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase II, core complex, nucleolus, nucleoplasm, nucleus
Pathways: DNA Repair, Dual incision in TC-NER, ESR-mediated signaling, Estrogen-dependent gene expression, FGFR2 alternative splicing, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism of RNA, Nucleotide Excision Repair, Processing of Capped Intron-Containing Pre-mRNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase - Mus musculus (mouse), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P60898
Entrez ID: 69920
|
Does Knockout of Dpysl3 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Dpysl3
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Dpysl3 (dihydropyrimidinase-like 3)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: actin crosslink formation, actin filament bundle assembly, cellular response to cytokine stimulus, negative regulation of cell migration, negative regulation of neuron projection development, nervous system development, neuron development, positive regulation of filopodium assembly, positive regulation of neuron projection development, pyrimidine nucleobase catabolic process, response to axon injury; MF: SH3 domain binding, chondroitin sulfate binding, dihydropyrimidinase activity, filamin binding, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, identical protein binding, phosphoprotein binding, protein binding; CC: cell body, cell projection, cytoplasm, cytosol, exocytic vesicle, extracellular space, filamentous actin, growth cone, lamellipodium, synapse
Pathways: Axon guidance, CRMPs in Sema3A signaling, Developmental Biology, Nervous system development, Semaphorin interactions
UniProt: Q62188
Entrez ID: 22240
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.