prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Trmt61a in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Trmt61a
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Trmt61a (tRNA methyltransferase 61A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, mRNA processing, methylation, tRNA methylation, tRNA processing; MF: mRNA (adenine-N1-)-methyltransferase activity, methyltransferase activity, tRNA (adenine(58)-N1)-methyltransferase activity, transferase activity; CC: nucleus, tRNA (m1A) methyltransferase complex
Pathways:
UniProt: Q80XC2
Entrez ID: 328162
|
Does Knockout of Mir1970 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Mir1970
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Mir1970 (microRNA 1970)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100316820
|
Does Knockout of Ddx49 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ddx49
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ddx49 (DEAD box helicase 49)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in positive regulation of cell growth; rRNA processing; and regulation of rRNA stability. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DDX49 (DEAD-box helicase 49). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: positive regulation of cell growth, rRNA processing, regulation of rRNA stability; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q4FZF3
Entrez ID: 234374
|
Does Knockout of Nfil3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Nfil3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nfil3 (nuclear factor, interleukin 3, regulated)
Type: protein-coding
Summary: The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses Per1 and Per2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: DNA-templated transcription, cellular response to interleukin-4, circadian rhythm, immune response, natural killer cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, regulation of DNA-templated transcription, rhythmic process, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, identical protein binding, protein binding; CC: RNA polymerase II transcription regulator complex, nucleus
Pathways:
UniProt: O08750
Entrez ID: 18030
|
Does Knockout of Rnf114 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Rnf114
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rnf114 (ring finger protein 114)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and plasma membrane. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human RNF114 (ring finger protein 114). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, protein polyubiquitination, protein ubiquitination, spermatogenesis, ubiquitin-dependent protein catabolic process; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleus, plasma membrane
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q9ET26
Entrez ID: 81018
|
Does Knockout of Fancc in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,550
|
Knockout
|
Fancc
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Fancc (Fanconi anemia, complementation group C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, brain morphogenesis, cellular response to oxidative stress, gamete generation, germ cell development, interstrand cross-link repair, myeloid cell homeostasis, neuronal stem cell population maintenance, nucleotide-excision repair, removal of superoxide radicals; CC: Fanconi anaemia nuclear complex, chromatin, cytoplasm, cytosol, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: P50652
Entrez ID: 14088
|
Does Knockout of Leng8 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Leng8
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Leng8 (leukocyte receptor cluster (LRC) member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8CBY3
Entrez ID: 232798
|
Does Knockout of Tmem115 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Tmem115
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tmem115 (transmembrane protein 115)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; MF: identical protein binding; CC: Golgi apparatus, Golgi cisterna membrane, Golgi transport complex, membrane, nucleus
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9WUH1
Entrez ID: 56395
|
Does Knockout of Rsl24d1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Rsl24d1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rsl24d1 (ribosomal L24 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome biogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Ribosome - Mus musculus (mouse)
UniProt: Q99L28
Entrez ID: 225215
|
Does Knockout of Lsm6 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Lsm6
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Lsm6 (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA catabolic process, mRNA processing, mRNA splicing, via spliceosome, maturation of SSU-rRNA, rRNA processing, tRNA processing; MF: RNA binding, protein heterodimerization activity; CC: Lsm2-8 complex, P-body, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, nucleolus, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex, spliceosomal complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: P62313
Entrez ID: 78651
|
Does Knockout of Hsf4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Hsf4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hsf4 (heat shock transcription factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lens fiber cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein phosphatase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nuclear speck, nucleus
Pathways:
UniProt: Q9R0L1
Entrez ID: 26386
|
Does Knockout of Ctc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Ctc1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ctc1 (CTS telomere maintenance complex component 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, bone marrow development, chromosome organization, hematopoietic stem cell proliferation, multicellular organism growth, negative regulation of telomere maintenance via telomerase, positive regulation of DNA replication, positive regulation of fibroblast proliferation, regulation of G2/M transition of mitotic cell cycle, replicative senescence, spleen development, telomere maintenance, telomere maintenance via telomere lengthening, thymus development; MF: DNA binding, G-rich strand telomeric DNA binding, protein binding, single-stranded DNA binding, telomeric DNA binding; CC: CST complex, chromosome, chromosome, telomeric region, cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: Q5SUQ9
Entrez ID: 68964
|
Does Knockout of Creb1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Creb1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Creb1 (cAMP responsive element binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, cAMP/PKA signal transduction, cell differentiation, cellular response to fatty acid, cellular response to forskolin, cellular response to growth factor stimulus, cellular response to hepatocyte growth factor stimulus, cellular response to insulin-like growth factor stimulus, cellular response to leukemia inhibitory factor, cellular response to nerve growth factor stimulus, cellular response to platelet-derived growth factor stimulus, cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, cellular response to zinc ion, chemotaxis to arachidonate, circadian rhythm, inhibition of non-skeletal tissue mineralization, lactation, lung epithelium development, lung saccule development, mRNA transcription by RNA polymerase II, mammary gland development, memory, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of transcription by competitive promoter binding, pituitary gland development, positive regulation of DNA-templated transcription, positive regulation of RNA polymerase II transcription preinitiation complex assembly, positive regulation of apoptotic process, positive regulation of cardiac muscle tissue development, positive regulation of fat cell differentiation, positive regulation of hormone secretion, positive regulation of lipid biosynthetic process, positive regulation of long-term synaptic potentiation, positive regulation of membrane depolarization, positive regulation of multicellular organism growth, positive regulation of osteoclast differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta3 production, protein stabilization, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell size, regulation of fibroblast proliferation, regulation of glial cell proliferation, regulation of testosterone biosynthetic process, regulation of transcription by RNA polymerase II, response to L-glutamate, response to activity, response to cocaine, response to dehydroepiandrosterone, response to erythropoietin, response to ethanol, response to glucagon, response to hypobaric hypoxia, response to hypoxia, response to morphine, response to nicotine, response to purine-containing compound, response to xenobiotic stimulus, rhythmic process, secretory granule organization, transcription by RNA polymerase II, transforming growth factor beta receptor signaling pathway, type I pneumocyte differentiation, visual learning; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, Hsp70 protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, arrestin family protein binding, cAMP response element binding, double-stranded DNA binding, enzyme binding, histone acetyltransferase binding, identical protein binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coactivator binding; CC: ATF4-CREB1 transcription factor complex, RNA polymerase II transcription regulator complex, axon, centrosome, chromatin, ciliary basal body, cytosol, euchromatin, mitochondrial matrix, nucleoplasm, nucleus, transcription regulator complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Circadian rhythm - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Vasopressin-regulated water reabsorption - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q01147
Entrez ID: 12912
|
Does Knockout of Scarna3b in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Scarna3b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Scarna3b (small Cajal body-specific RNA 3B)
Type: ncRNA
Summary: small Cajal body-specific RNA 3B
Gene Ontology: BP: RNA processing, biological_process; CC: Cajal body, cellular_component, nucleolus
Pathways:
UniProt:
Entrez ID: 100217447
|
Does Knockout of Catsperz in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Catsperz
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Catsperz (cation channel sperm associated auxiliary subunit zeta)
Type: protein-coding
Summary: Involved in flagellated sperm motility; male meiotic nuclear division; and sperm capacitation. Located in sperm principal piece. Part of CatSper complex. Is expressed in alimentary system; genitourinary system; and skin. Orthologous to human CATSPERZ (catsper channel auxiliary subunit zeta). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, flagellated sperm motility, male meiotic nuclear division, sperm capacitation, spermatogenesis; CC: CatSper complex, cell projection, cilium, cytoplasm, membrane, motile cilium, plasma membrane, sperm principal piece
Pathways:
UniProt: Q9CQP8
Entrez ID: 67077
|
Does Knockout of Rad54l2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Rad54l2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rad54l2 (RAD54 like 2 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of transcription by RNA polymerase II; MF: ATP binding, ATP hydrolysis activity, ATP-dependent chromatin remodeler activity, DNA binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, protein kinase binding, transcription coregulator activity; CC: nuclear body, nuclear speck, nucleus
Pathways:
UniProt: Q99NG0
Entrez ID: 81000
|
Does Knockout of Ap4b1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Ap4b1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ap4b1 (adaptor-related protein complex AP-4, beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, protein localization to somatodendritic compartment, protein targeting, protein transport, vesicle-mediated transport; MF: clathrin binding, protein binding; CC: AP-4 adaptor complex, Golgi apparatus, clathrin adaptor complex, cytoplasmic side of trans-Golgi network transport vesicle membrane, cytosol, membrane, membrane coat, trans-Golgi network
Pathways: Golgi Associated Vesicle Biogenesis, Lysosome - Mus musculus (mouse), Lysosome Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q9WV76
Entrez ID: 67489
|
Does Knockout of Nudt8 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Nudt8
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nudt8 (nudix hydrolase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetyl-CoA catabolic process, biological_process, butyryl-CoA catabolic process, coenzyme A catabolic process, malonyl-CoA catabolic process, medium-chain fatty-acyl-CoA catabolic process, propionyl-CoA catabolic process, succinyl-CoA catabolic process; MF: coenzyme A diphosphatase activity, hydrolase activity, magnesium ion binding, manganese ion binding, metal ion binding, molecular_function; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q9CR24
Entrez ID: 66387
|
Does Knockout of Meaf6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,286
|
Knockout
|
Meaf6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Meaf6 (MYST/Esa1-associated factor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA biosynthetic process, regulation of DNA replication, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of cell growth, regulation of developmental process, regulation of double-strand break repair, regulation of hemopoiesis; MF: histone H3K14 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity; CC: MOZ/MORF histone acetyltransferase complex, NuA4 histone acetyltransferase complex, chromosome, chromosome, centromeric region, histone acetyltransferase complex, kinetochore, nucleolus, nucleoplasm, nucleosome, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Transcriptional Regulation by TP53
UniProt: Q2VPQ9
Entrez ID: 70088
|
Does Knockout of Hdhd3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Hdhd3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hdhd3 (haloacid dehalogenase-like hydrolase domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrion, nucleolus, nucleus
Pathways:
UniProt: Q9CYW4
Entrez ID: 72748
|
Does Knockout of Fdx1 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Fdx1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Fdx1 (ferredoxin 1)
Type: protein-coding
Summary: Ferrodoxins are iron-sulfur proteins that facilitate monooxygenase reactions catalyzed by P450 enzymes. The protein encoded by this gene is present in the mitochondrial matrix and transfers electrons from ferredoxin reductase to steroidogenic mitochondrial cytochrome P450 proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: P450-containing electron transport chain, cellular response to cAMP, cellular response to forskolin, cholesterol metabolic process, electron transport chain, hormone biosynthetic process, lipid metabolic process, regulation of NADP metabolic process, steroid biosynthetic process, steroid metabolic process; MF: 2 iron, 2 sulfur cluster binding, cholesterol monooxygenase (side-chain-cleaving) activity, electron transfer activity, iron-sulfur cluster binding, metal ion binding; CC: mitochondrial crista, mitochondrial matrix, mitochondrion
Pathways: Biological oxidations, Cytochrome P450 - arranged by substrate type, Electron transport from NADPH to Ferredoxin, Endogenous sterols, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroid hormones, Metabolism of steroids, Mitochondrial iron-sulfur cluster biogenesis, Phase I - Functionalization of compounds, Post-translational protein modification, Pregnenolone biosynthesis, Protein lipoylation, biosynthesis of androgens, biosynthesis of corticosteroids, biosynthesis of estrogens
UniProt: P46656
Entrez ID: 14148
|
Does Knockout of Ttc3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Ttc3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ttc3 (tetratricopeptide repeat domain 3)
Type: protein-coding
Summary: Predicted to enable ubiquitin-protein transferase activity. Involved in negative regulation of axon extension and negative regulation of neuron differentiation. Located in vacuole. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human TTC3 (tetratricopeptide repeat domain 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of axon extension, negative regulation of neuron differentiation, protein K48-linked ubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, vacuole
Pathways:
UniProt: Q05BF2, G5E8T2, E9QAH3, D6RHT6, G5E8U3, A0A338P6H3, D6RFU5, D3Z2K0, F6XYB0, F7DAQ7, A0A338P6W3, D6RD03, A0A338P6J6, D3Z485, F6ZS17, D3Z330, D6RDD2, D3YZA6, D6REF1, D3Z502, D3Z3E5, D3YZ03, A0A0R4J1T2, A0A338P789, A0A338P718
Entrez ID: 22129
|
Does Knockout of Ankrd35 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Ankrd35
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ankrd35 (ankyrin repeat domain 35)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: actin binding, molecular_function
Pathways:
UniProt: D6RGN5, E9Q9D8
Entrez ID: 213121
|
Does Knockout of Atpaf1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Atpaf1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atpaf1 (ATP synthase mitochondrial F1 complex assembly factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial proton-transporting ATP synthase complex assembly, protein-containing complex assembly; MF: molecular_function, protein-containing complex stabilizing activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q811I0
Entrez ID: 230649
|
Does Knockout of Iqsec2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Iqsec2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Iqsec2 (IQ motif and Sec7 domain 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, modulation of chemical synaptic transmission, positive regulation of long-term synaptic depression, positive regulation of synapse assembly, positive regulation of synaptic transmission, glutamatergic, regulation of ARF protein signal transduction, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; MF: guanyl-nucleotide exchange factor activity; CC: Schaffer collateral - CA1 synapse, cytoplasm, glutamatergic synapse, photoreceptor ribbon synapse, postsynaptic density membrane, postsynaptic density, intracellular component, presynaptic active zone cytoplasmic component
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q5DU25
Entrez ID: 245666
|
Does Knockout of Nudcd3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Nudcd3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nudcd3 (NudC domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, protein folding, protein localization to pericentriolar material; CC: cytoplasm, cytoplasmic dynein complex
Pathways:
UniProt: Q8R1N4
Entrez ID: 209586
|
Does Knockout of Cadm4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Cadm4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cadm4 (cell adhesion molecule 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of peptidyl-threonine phosphorylation, negative regulation of peptidyl-tyrosine phosphorylation, negative regulation of protein phosphorylation, negative regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of vascular endothelial growth factor signaling pathway, regulation of Rac protein signal transduction, regulation of cell motility, regulation of cell population proliferation, regulation of protein phosphorylation, regulation of wound healing, synaptic membrane adhesion; MF: protein phosphatase binding, receptor tyrosine kinase binding, vascular endothelial growth factor receptor 1 binding, vascular endothelial growth factor receptor 2 binding; CC: cell leading edge, cell-cell contact zone, membrane, synaptic membrane
Pathways:
UniProt: Q8R464
Entrez ID: 260299
|
Does Knockout of Gemin7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gemin7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gemin7 (gem nuclear organelle associated protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, spliceosomal snRNP assembly; MF: RNA binding, protein binding; CC: Gemini of Cajal bodies, SMN complex, SMN-Sm protein complex, Sm-like protein family complex, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Metabolism of non-coding RNA, snRNP Assembly
UniProt: Q9CWY4
Entrez ID: 69731
|
Does Knockout of 1700018F24Rik in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
1700018F24Rik
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: 1700018F24Rik (RIKEN cDNA 1700018F24 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, molecular_function
Pathways:
UniProt: B2RW27
Entrez ID: 69396
|
Does Knockout of Sfpq in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Sfpq
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sfpq (splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, RNA splicing, activation of innate immune response, alternative mRNA splicing, via spliceosome, chromatin remodeling, chromosome organization, dendritic transport of messenger ribonucleoprotein complex, double-strand break repair via homologous recombination, immune system process, innate immune response, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of circadian rhythm, negative regulation of transcription by RNA polymerase II, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of sister chromatid cohesion, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of circadian rhythm, rhythmic process; MF: DNA binding, RNA binding, chromatin binding, histone deacetylase binding, nucleic acid binding, protein binding, protein homodimerization activity, transcription cis-regulatory region binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, dendrite, nuclear matrix, nuclear speck, nucleoplasm, nucleus, paraspeckles
Pathways: PTK6 Regulates Proteins Involved in RNA Processing, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6
UniProt: Q8VIJ6
Entrez ID: 71514
|
Does Knockout of Gm4744 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Gm4744
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm4744 (trypsinogen pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 194360
|
Does Knockout of Hmg20a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Hmg20a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hmg20a (high mobility group 20A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of neuron differentiation, negative regulation of protein sumoylation, negative regulation of transcription by RNA polymerase II, regulation of gene expression; MF: DNA binding, identical protein binding, protein binding; CC: nucleus
Pathways:
UniProt: Q9DC33
Entrez ID: 66867
|
Does Knockout of Xpc in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Xpc
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Xpc (xeroderma pigmentosum, complementation group C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, UV-damage excision repair, mismatch repair, mitotic intra-S DNA damage checkpoint signaling, negative regulation of gluconeogenesis, nucleotide-excision repair, positive regulation of DNA-templated transcription, pyrimidine dimer repair by nucleotide-excision repair, regulation of cell cycle phase transition, regulation of mitotic cell cycle, regulation of mitotic cell cycle phase transition, response to UV-B, response to auditory stimulus, response to xenobiotic stimulus; MF: DNA binding, DNA damage sensor activity, RNA polymerase II-specific DNA-binding transcription factor binding, damaged DNA binding, protein binding, protein-containing complex binding, single-stranded DNA binding, transcription coactivator activity; CC: XPC complex, chromosome, cytoplasm, cytosol, mitochondrion, nucleolus, nucleoplasm, nucleotide-excision repair complex, nucleotide-excision repair factor 2 complex, nucleus, plasma membrane, site of DNA damage
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Formation of Incision Complex in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: P51612
Entrez ID: 22591
|
Does Knockout of Pgk1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Pgk1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Pgk1 (phosphoglycerate kinase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Many pseudogenes of this gene are found throughout the mouse genome. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: canonical glycolysis, cellular response to hypoxia, epithelial cell differentiation, gluconeogenesis, glyceraldehyde-3-phosphate biosynthetic process, glycolytic process, negative regulation of angiogenesis, negative regulation of pyruvate decarboxylation to acetyl-CoA, plasminogen activation; MF: ADP binding, ATP binding, kinase activity, metal ion binding, nucleotide binding, phosphoglycerate kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-disulfide reductase [NAD(P)H] activity, transferase activity, transmembrane transporter binding; CC: cytoplasm, cytosol, extracellular space, membrane raft, mitochondrial matrix, mitochondrion
Pathways: Gluconeogenesis, Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, gluconeogenesis I, glycolysis I, glycolysis III
UniProt: P09411
Entrez ID: 18655
|
Does Knockout of Alx4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Alx4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Alx4 (aristaless-like homeobox 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, anterior/posterior pattern specification, digestive tract development, embryonic digit morphogenesis, embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, embryonic skeletal system morphogenesis, hair follicle development, limb morphogenesis, muscle organ development, neuron development, pattern specification process, positive regulation of transcription by RNA polymerase II, post-embryonic development, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of transcription by RNA polymerase II, roof of mouth development, skeletal system morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, HMG box domain binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: O35137
Entrez ID: 11695
|
Does Knockout of Ffar1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Ffar1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ffar1 (free fatty acid receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, glucose homeostasis, insulin secretion, ligand-gated ion channel signaling pathway, negative regulation of interleukin-1 beta production, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of calcium ion transport, positive regulation of calcium ion transport into cytosol, positive regulation of cytosolic calcium ion concentration, positive regulation of insulin secretion, regulation of insulin secretion, response to fatty acid, signal transduction; MF: G protein-coupled receptor activity, bioactive lipid receptor activity, fatty acid binding, lipid binding; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Free fatty acid receptors, Free fatty acids regulate insulin secretion, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Incretin synthesis, secretion, and inactivation, Insulin secretion - Mus musculus (mouse), Integration of energy metabolism, Metabolism, Metabolism of proteins, Peptide hormone metabolism, Regulation of insulin secretion, Signal Transduction, Signaling by GPCR, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
UniProt: Q76JU9
Entrez ID: 233081
|
Does Knockout of Dr1 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Dr1
|
response to virus
|
Microglial Cell Line
|
Gene: Dr1 (down-regulator of transcription 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, general transcription initiation factor activity, protein binding, protein heterodimerization activity; CC: ATAC complex, RNA polymerase II transcription regulator complex, mitotic spindle, negative cofactor 2 complex, nucleoplasm, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription)
UniProt: Q91WV0
Entrez ID: 13486
|
Does Knockout of Cacna1b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Cacna1b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cacna1b (calcium channel, voltage-dependent, N type, alpha 1B subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion import, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, chemical synaptic transmission, establishment of localization in cell, locomotory behavior, modulation of chemical synaptic transmission, monoatomic ion transmembrane transport, monoatomic ion transport, neurotransmitter secretion, positive regulation of calcium ion-dependent exocytosis of neurotransmitter, positive regulation of neurotransmitter secretion, regulation of blood pressure, regulation of calcium ion transport, regulation of calcium-dependent activation of synaptic vesicle fusion, regulation of heart contraction, regulation of transport, response to amyloid-beta, response to pain, response to phorbol 13-acetate 12-myristate, response to testosterone, system process, transmembrane transport; MF: ATP binding, calcium channel activity, calcium ion binding, high voltage-gated calcium channel activity, metal ion binding, monoatomic ion channel activity, nucleotide binding, protein binding, protein phosphatase 2A binding, voltage-gated calcium channel activity, voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; CC: Schaffer collateral - CA1 synapse, axon terminus, dendrite, dendritic shaft, glutamatergic synapse, membrane, monoatomic ion channel complex, neuronal cell body, presynapse, presynaptic active zone, protein-containing complex, voltage-gated calcium channel complex
Pathways: Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), GABAergic synapse - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Neuronal System, Nicotine addiction - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Presynaptic depolarization and calcium channel opening, Prion disease - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Type II diabetes mellitus - Mus musculus (mouse)
UniProt: O55017
Entrez ID: 12287
|
Does Knockout of Snap47 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Snap47
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Snap47 (synaptosomal-associated protein, 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytic insertion of neurotransmitter receptor to postsynaptic membrane, exocytosis, long-term synaptic potentiation, synaptic vesicle fusion to presynaptic active zone membrane, synaptic vesicle priming, vesicle-mediated transport in synapse; MF: SNAP receptor activity, syntaxin binding; CC: BLOC-1 complex, SNARE complex, asymmetric synapse, cytoplasm, dendrite, endomembrane system, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane, neuronal cell body, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, presynaptic active zone, synapse
Pathways:
UniProt: Q8R570
Entrez ID: 67826
|
Does Knockout of Crip2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Crip2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Crip2 (cysteine rich protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hemopoiesis, positive regulation of cell population proliferation; MF: metal ion binding, protein binding
Pathways:
UniProt: Q9DCT8
Entrez ID: 68337
|
Does Knockout of Cr2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Cr2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cr2 (complement receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell differentiation, B cell proliferation, T cell mediated immunity, antiviral innate immune response, complement activation, alternative pathway, complement activation, classical pathway, complement receptor mediated signaling pathway, immune system process, innate immune response, negative regulation of complement activation, classical pathway, symbiont entry into host cell, type I interferon-mediated signaling pathway; MF: DNA binding, complement binding, complement receptor activity, immunoglobulin receptor binding, protein binding, protein homodimerization activity, signaling receptor activity, transmembrane signaling receptor activity; CC: cell surface, external side of plasma membrane, extracellular space, membrane, plasma membrane, receptor complex
Pathways: B cell receptor signaling pathway - Mus musculus (mouse), Complement and coagulation cascades - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse)
UniProt: A0A1B0GS59, Q9DC83, Q32M14, A0A0A6YXU7, E9Q3S5, A0A0A6YWG3, A0A0A6YWU7
Entrez ID: 12902
|
Does Knockout of Htr1d in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Htr1d
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Htr1d (5-hydroxytryptamine (serotonin) receptor 1D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting serotonin receptor signaling pathway, chemical synaptic transmission, intestine smooth muscle contraction, regulation of behavior, regulation of locomotion, regulation of synaptic vesicle exocytosis, response to toxic substance, signal transduction, smooth muscle contraction, vasoconstriction; MF: G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, Gi/o-coupled serotonin receptor activity, neurotransmitter receptor activity, serotonin binding, serotonin receptor activity; CC: dendrite, glutamatergic synapse, membrane, neuronal dense core vesicle, plasma membrane, synapse
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Serotonin receptors, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q61224
Entrez ID: 15552
|
Does Knockout of Ap5m1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Ap5m1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ap5m1 (adaptor-related protein complex 5, mu 1 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosomal transport, protein transport, vesicle-mediated transport; CC: AP-5 adaptor complex, AP-type membrane coat adaptor complex, cytoplasm, cytosol, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane
Pathways:
UniProt: Q8BJ63
Entrez ID: 74385
|
Does Knockout of Pax4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Pax4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pax4 (paired box 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, brain development, cell differentiation, circadian rhythm, forebrain development, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of epithelial cell differentiation, regulation of DNA-templated transcription, regulation of cell differentiation, regulation of transcription by RNA polymerase II, response to cAMP, response to xenobiotic stimulus, retina development in camera-type eye, sensory organ development, type B pancreatic cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: nucleus, transcription regulator complex
Pathways: Maturity onset diabetes of the young - Mus musculus (mouse)
UniProt: P32115
Entrez ID: 18506
|
Does Knockout of Comt in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Comt
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Comt (catechol-O-methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: artery development, behavioral fear response, catechol-containing compound metabolic process, catecholamine catabolic process, catecholamine metabolic process, cellular response to cocaine, cellular response to phosphate starvation, cerebellar cortex morphogenesis, cholesterol efflux, cognition, detection of temperature stimulus involved in sensory perception of pain, developmental process, dopamine catabolic process, dopamine metabolic process, dopamine secretion, estrogen metabolic process, exploration behavior, fear response, female pregnancy, gene expression, glomerulus development, glycogen metabolic process, habituation, kidney development, learning, learning or memory, lipid metabolic process, mastication, memory, methylation, multicellular organism growth, multicellular organismal response to stress, negative regulation of dopamine metabolic process, negative regulation of smooth muscle cell proliferation, nervous system process, norepinephrine metabolic process, norepinephrine secretion, positive regulation of homocysteine metabolic process, prostaglandin metabolic process, regulation of blood pressure, renal albumin absorption, renal filtration, renal sodium excretion, renin secretion into blood stream, response to amphetamine, response to angiotensin, response to corticosterone, response to cytokine, response to dopamine, response to food, response to hypoxia, response to oxidative stress, response to pain, response to salt, response to stress, response to temperature stimulus, response to toxic substance, response to wounding, response to xenobiotic stimulus, short-term memory, startle response, synaptic transmission, dopaminergic, visual learning; MF: O-methyltransferase activity, catechol O-methyltransferase activity, magnesium ion binding, metal ion binding, methyltransferase activity, transferase activity; CC: axon, cell body, cytoplasm, cytosol, dendrite, dendritic spine, glutamatergic synapse, membrane, mitochondrion, plasma membrane, postsynapse, postsynaptic membrane, synapse, vesicle
Pathways: Biological oxidations, Dopamine clearance from the synaptic cleft, Dopaminergic synapse - Mus musculus (mouse), Enzymatic degradation of Dopamine by monoamine oxidase, Enzymatic degradation of dopamine by COMT, Metabolism, Methylation, Neuronal System, Neurotransmitter clearance, Phase II - Conjugation of compounds, Steroid hormone biosynthesis - Mus musculus (mouse), Transmission across Chemical Synapses, Tyrosine metabolism - Mus musculus (mouse), dopamine degradation
UniProt: O88587
Entrez ID: 12846
|
Does Knockout of Abhd12b in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Abhd12b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Abhd12b (abhydrolase domain containing 12B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoacylglycerol catabolic process, phosphatidylserine catabolic process; MF: monoacylglycerol lipase activity, phosphatidylcholine lysophospholipase activity
Pathways:
UniProt: S4R1Y3, G3UZN6, S4R2K4
Entrez ID: 100504285
|
Does Knockout of Naa50 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Naa50
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Naa50 (N(alpha)-acetyltransferase 50, NatE catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-terminal protein amino acid acetylation, chromatin remodeling, establishment of mitotic sister chromatid cohesion, mitotic sister chromatid cohesion, mitotic sister chromatid cohesion, centromeric, post-translational protein modification; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, histone H4 acetyltransferase activity, protein N-terminal-methionine acetyltransferase activity, protein binding, protein-N-terminal amino-acid acetyltransferase activity, protein-lysine-acetyltransferase activity, transferase activity; CC: NatA complex, cytoplasm, cytosol, nucleolus, nucleus
Pathways:
UniProt: Q6PGB6
Entrez ID: 72117
|
Does Knockout of Nfkbia in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Nfkbia
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Nfkbia (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha)
Type: protein-coding
Summary: Enables transcription regulator inhibitor activity. Involved in B cell receptor signaling pathway; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of transcription initiation by RNA polymerase II. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; negative regulation of Notch signaling pathway; and pattern recognition receptor signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and naris. Used to study Sjogren's syndrome and atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); hepatitis B; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: B cell receptor signaling pathway, canonical NF-kappaB signal transduction, cellular response to cytokine stimulus, cellular response to tumor necrosis factor, immune system process, inflammatory response, interleukin-1-mediated signaling pathway, lipopolysaccharide-mediated signaling pathway, negative regulation of Notch signaling pathway, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cholesterol transport, negative regulation of cytokine production involved in inflammatory response, negative regulation of lipid storage, negative regulation of macrophage derived foam cell differentiation, negative regulation of myeloid cell differentiation, negative regulation of protein import into nucleus, negative regulation of transcription by RNA polymerase II, non-canonical NF-kappaB signal transduction, nucleotide-binding oligomerization domain containing 1 signaling pathway, nucleotide-binding oligomerization domain containing 2 signaling pathway, positive regulation of DNA-templated transcription, positive regulation of inflammatory response, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein import into nucleus, regulation of cell population proliferation, regulation of gene expression, regulation of transcription by RNA polymerase II, response to exogenous dsRNA, response to lipopolysaccharide, response to muramyl dipeptide, response to muscle stretch, signal transduction involved in regulation of gene expression, toll-like receptor 4 signaling pathway, tumor necrosis factor-mediated signaling pathway; MF: NF-kappaB binding, enzyme binding, heat shock protein binding, identical protein binding, nuclear localization sequence binding, protein binding, protein sequestering activity, protein-containing complex binding, transcription regulator inhibitor activity, ubiquitin protein ligase binding; CC: I-kappaB/NF-kappaB complex, cytoplasm, cytosol, nucleus, plasma membrane, protein-containing complex
Pathways: Activation of NF-kappaB in B cells, Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytosolic DNA-sensing pathway - Mus musculus (mouse), Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, Death Receptor Signaling, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Insulin resistance - Mus musculus (mouse), Interleukin-1 family signaling, Interleukin-1 signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Legionellosis - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kB is activated and signals survival, NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Prostate cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), RIP-mediated NFkB activation via ZBP1, Relaxin signaling pathway - Mus musculus (mouse), Response of endothelial cells to shear stress, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of immune response proteins, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Signaling by the B Cell Receptor (BCR), Small cell lung cancer - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TAK1-dependent IKK and NF-kappa-B activation , TCR signaling, TNF signaling pathway - Mus musculus (mouse), TRAF6 mediated NF-kB activation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Ub-specific processing proteases, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), ZBP1(DAI) mediated induction of type I IFNs, cAMP signaling pathway - Mus musculus (mouse), p75 NTR receptor-mediated signalling, p75NTR signals via NF-kB
UniProt: Q9Z1E3
Entrez ID: 18035
|
Does Knockout of Ccndbp1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Ccndbp1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ccndbp1 (cyclin D-type binding-protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q3TVC7
Entrez ID: 17151
|
Does Knockout of Col14a1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Col14a1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Col14a1 (collagen, type XIV, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, collagen fibril organization, extracellular matrix organization, homeostasis of number of cells within a tissue, regulation of cell growth involved in cardiac muscle cell development, tissue development, ventricular cardiac muscle tissue development; CC: collagen trimer, extracellular matrix, extracellular region, extracellular space, interstitial matrix
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen formation, Extracellular matrix organization, Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q80X19
Entrez ID: 12818
|
Does Knockout of Nod1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Nod1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Nod1 (nucleotide-binding oligomerization domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to muramyl dipeptide, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, detection of bacterium, immune system process, innate immune response, intracellular signal transduction, nucleotide-binding oligomerization domain containing 1 signaling pathway, pattern recognition receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of apoptotic process, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cytokine production, positive regulation of dendritic cell antigen processing and presentation, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of macrophage cytokine production, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of stress-activated MAPK cascade, positive regulation of tumor necrosis factor production, positive regulation of xenophagy, regulation of apoptotic process, response to endoplasmic reticulum stress; MF: ATP binding, CARD domain binding, identical protein binding, nucleotide binding, pattern recognition receptor activity, peptidoglycan binding, protein binding, protein homodimerization activity, protein-containing complex binding, ubiquitin binding; CC: apical plasma membrane, basolateral plasma membrane, cytoplasm, cytosol, membrane, phagocytic vesicle, plasma membrane
Pathways: Cytokine Signaling in Immune system, Deubiquitination, Immune System, Innate Immune System, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, MAP kinase activation, Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NOD-like receptor signaling pathway - Mus musculus (mouse), NOD1/2 Signaling Pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Ovarian tumor domain proteases, Pertussis - Mus musculus (mouse), Post-translational protein modification, Salmonella infection - Mus musculus (mouse), Signaling by Interleukins, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, activated TAK1 mediates p38 MAPK activation
UniProt: Q8BHB0
Entrez ID: 107607
|
Does Knockout of Krt90 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Krt90
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Krt90 (keratin 90)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermediate filament organization, keratinization; CC: intermediate filament, keratin filament
Pathways:
UniProt: E9Q1Z0, Q8BIS2
Entrez ID: 239673
|
Does Knockout of Ctr9 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ctr9
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ctr9 (CTR9 homolog, Paf1/RNA polymerase II complex component)
Type: protein-coding
Summary: Enables SH2 domain binding activity. Involved in several processes, including cell surface receptor signaling pathway; cellular response to lipopolysaccharide; and endodermal cell fate commitment. Acts upstream of or within blastocyst development and negative regulation of gene expression, epigenetic. Located in euchromatin and nucleus. Part of Cdc73/Paf1 complex. Is expressed in cerebral cortex and telencephalon. Orthologous to human CTR9 (CTR9 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Wnt signaling pathway, blastocyst growth, blastocyst hatching, cell surface receptor signaling pathway via JAK-STAT, cellular response to lipopolysaccharide, chromatin organization, endodermal cell fate commitment, inner cell mass cell differentiation, interleukin-6-mediated signaling pathway, negative regulation of gene expression, epigenetic, negative regulation of myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II, trophectodermal cell differentiation; MF: RNA polymerase II complex binding, SH2 domain binding, protein binding; CC: Cdc73/Paf1 complex, euchromatin, nuclear speck, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q62018
Entrez ID: 22083
|
Does Knockout of Nup107 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Nup107
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nup107 (nucleoporin 107)
Type: protein-coding
Summary: Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including nuclear pore complex assembly; nucleocytoplasmic transport; and post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to be located in nuclear membrane and nuclear periphery. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Is expressed in embryo and neural tube. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome; nephrotic syndrome type 11; and ovarian dysgenesis 6. Orthologous to human NUP107 (nucleoporin 107). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: female gonad development, mRNA export from nucleus, mRNA transport, nephron development, nuclear pore complex assembly, nucleocytoplasmic transport, post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery, protein import into nucleus, protein transport; MF: structural constituent of nuclear pore; CC: chromosome, chromosome, centromeric region, kinetochore, membrane, nuclear envelope, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore outer ring, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q8BH74
Entrez ID: 103468
|
Does Knockout of Ly6g6e in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Ly6g6e
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ly6g6e (lymphocyte antigen 6 family member G6E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine receptor signaling pathway, cell surface receptor protein serine/threonine kinase signaling pathway, desensitization of G protein-coupled receptor signaling pathway; MF: acetylcholine receptor activator activity, acetylcholine receptor binding, transmembrane receptor protein serine/threonine kinase activity; CC: cell projection, cell surface, membrane, plasma membrane, synapse
Pathways:
UniProt: Q8K1T6
Entrez ID: 70274
|
Does Knockout of Il10ra in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Il10ra
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Il10ra (interleukin 10 receptor, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, interleukin-10-mediated signaling pathway, intestinal epithelial structure maintenance, negative regulation of autophagy, negative regulation of inflammatory response, positive regulation of receptor signaling pathway via JAK-STAT, regulation of synapse organization, ubiquitin-dependent endocytosis; MF: interleukin-10 binding, interleukin-10 receptor activity; CC: apical plasma membrane, cilium, cytoplasm, cytosol, membrane, nucleoplasm, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Immune System, Interleukin-10 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Signaling by Interleukins, Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q61727
Entrez ID: 16154
|
Does Knockout of Cnot6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Cnot6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cnot6 (CCR4-NOT transcription complex, subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: miRNA-mediated gene silencing by mRNA destabilization, nuclear-transcribed mRNA catabolic process, no-go decay, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of cytoplasmic mRNA processing body assembly, regulation of translation, regulatory ncRNA-mediated gene silencing; MF: 3'-5'-RNA exonuclease activity, RNA binding, RNA exonuclease activity, catalytic activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, poly(A)-specific ribonuclease activity, transcription coactivator activity; CC: CCR4-NOT complex, cytoplasm, cytosol, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Polymerase II Transcription, RNA degradation - Mus musculus (mouse), TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: Q8K3P5
Entrez ID: 104625
|
Does Knockout of Rragb in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Rragb
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rragb (Ras-related GTP binding B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to leucine starvation, cellular response to starvation, intracellular protein localization, negative regulation of autophagy, positive regulation of TOR signaling, positive regulation of TORC1 signaling, regulation of TOR signaling; MF: GTP binding, GTPase activity, GTPase binding, guanyl ribonucleotide binding, hydrolase activity, nucleotide binding; CC: Gtr1-Gtr2 GTPase complex, cytoplasm, lysosomal membrane, lysosome, membrane, nucleus
Pathways: Amino acids regulate mTORC1, Autophagy, Autophagy - animal - Mus musculus (mouse), Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q6NTA4
Entrez ID: 245670
|
Does Knockout of Vps28 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Vps28
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Vps28 (vacuolar protein sorting 28)
Type: protein-coding
Summary: This gene encodes a protein which is thought to be a subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: endosome transport via multivesicular body sorting pathway, negative regulation of protein ubiquitination, positive regulation of protein catabolic process, positive regulation of ubiquitin-dependent endocytosis, protein transport, protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; MF: protein binding, protein-containing complex binding, ubiquitin binding; CC: ESCRT I complex, cytoplasm, cytosol, early endosome, endosome, endosome membrane, late endosome membrane, membrane, plasma membrane
Pathways: Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9D1C8
Entrez ID: 66914
|
Does Knockout of Gas8 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Gas8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gas8 (growth arrest specific 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axoneme assembly, brain development, cell motility, cilium movement involved in cell motility, determination of left/right symmetry, epithelial cilium movement involved in extracellular fluid movement, establishment of localization in cell, flagellated sperm motility, intracellular protein localization, microtubule cytoskeleton organization, positive regulation of protein localization to cilium, positive regulation of smoothened signaling pathway; MF: microtubule binding, protein binding, small GTPase binding; CC: 9+2 motile cilium, Golgi apparatus, axoneme, cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, extracellular region, glial cell projection, microtubule, microtubule cytoskeleton, motile cilium, plasma membrane, sperm flagellum
Pathways: Activation of SMO, Hedgehog 'on' state, Signal Transduction, Signaling by Hedgehog
UniProt: Q60779
Entrez ID: 104346
|
Does Knockout of Cxxc1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Cxxc1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cxxc1 (CXXC finger protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: DNA binding, cis-regulatory region sequence-specific DNA binding, histone H3K4me3 reader activity, metal ion binding, protein binding, unmethylated CpG binding, zinc ion binding; CC: Set1C/COMPASS complex, cytosol, histone methyltransferase complex, nuclear lumen, nuclear matrix, nuclear speck, nucleoplasm, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription)
UniProt: Q9CWW7
Entrez ID: 74322
|
Does Knockout of Itga10 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Itga10
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Itga10 (integrin, alpha 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell migration, cell-cell adhesion, cell-matrix adhesion, integrin-mediated signaling pathway; MF: collagen binding involved in cell-matrix adhesion, metal ion binding, signaling receptor activity; CC: cell surface, integrin alpha10-beta1 complex, integrin complex, membrane
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), ECM-receptor interaction - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse)
UniProt: E9Q6R1, E9PXZ3
Entrez ID: 213119
|
Does Knockout of Haus8 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Haus8
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Haus8 (4HAUS augmin-like complex, subunit 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome cycle, spindle assembly; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, microtubule, mitotic spindle microtubule, nuclear microtubule, spindle, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q99L00
Entrez ID: 76478
|
Does Knockout of Bcas2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Bcas2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Bcas2 (BCAS2 pre-mRNA processing factor)
Type: protein-coding
Summary: Acts upstream of or within several processes, including alternative mRNA splicing, via spliceosome; ovarian follicle development; and spindle assembly. Part of Prp19 complex. Is expressed in several structures, including central nervous system; early conceptus; oocyte; peripheral nervous system ganglion; and submandibular gland primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, oocyte development, oogenesis, ovarian follicle development, protein catabolic process, spindle assembly; CC: DNA replication factor A complex, Prp19 complex, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, centrosome, nuclear speck, nucleolus, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9D287
Entrez ID: 68183
|
Does Knockout of Nup210l in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Nup210l
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nup210l (nucleoporin 210-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Sertoli cell development, spermatid development; CC: membrane, nuclear membrane, nuclear pore, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q9D2F7
Entrez ID: 77595
|
Does Knockout of B3gat2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
B3gat2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: B3gat2 (beta-1,3-glucuronyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate biosynthetic process, carbohydrate metabolic process, chondroitin sulfate proteoglycan biosynthetic process, protein glycosylation; MF: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity, metal ion binding, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosaminoglycan metabolism, Glycosaminoglycan-protein linkage region biosynthesis, Mannose type O-glycan biosynthesis - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, chondroitin sulfate biosynthesis, dermatan sulfate biosynthesis, glycoaminoglycan-protein linkage region biosynthesis, heparan sulfate biosynthesis
UniProt: P59270
Entrez ID: 280645
|
Does Knockout of Tbk1 in Melanoma Cell Line causally result in tumorigenicity?
| 1
| 616
|
Knockout
|
Tbk1
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Tbk1 (TANK-binding kinase 1)
Type: protein-coding
Summary: Enables several functions, including identical protein binding activity; protein phosphatase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including peptidyl-serine phosphorylation; positive regulation of signal transduction; and positive regulation of xenophagy. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis 4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: T follicular helper cell differentiation, TORC1 signaling, TORC2 signaling, activation of innate immune response, antiviral innate immune response, cGAS/STING signaling pathway, cellular response to nutrient levels, cytoplasmic pattern recognition receptor signaling pathway, cytoplasmic translation, defense response to Gram-positive bacterium, defense response to other organism, defense response to virus, dendritic cell proliferation, immune system process, innate immune response, mRNA transcription, negative regulation of TORC1 signaling, negative regulation of gene expression, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of TORC2 signaling, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of macroautophagy, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of transcription by RNA polymerase II, positive regulation of translational initiation, positive regulation of type I interferon production, positive regulation of type I interferon-mediated signaling pathway, positive regulation of xenophagy, protein import into nucleus, protein phosphorylation, regulation of gene expression, regulation of type I interferon production, toll-like receptor 4 signaling pathway; MF: ATP binding, RNA polymerase II-specific DNA-binding transcription factor binding, identical protein binding, kinase activity, nucleic acid binding, nucleotide binding, phosphoprotein binding, protein binding, protein kinase activity, protein phosphatase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Alcoholic liver disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytosolic DNA-sensing pathway - Mus musculus (mouse), Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, Death Receptor Signaling, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), IRF3-mediated induction of type I IFN, Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Interleukin-1 family signaling, Interleukin-37 signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Macroautophagy, Measles - Mus musculus (mouse), Mitophagy, Mitophagy - animal - Mus musculus (mouse), MyD88-independent TLR4 cascade , NOD-like receptor signaling pathway - Mus musculus (mouse), Negative regulators of DDX58/IFIH1 signaling, PINK1-PRKN Mediated Mitophagy, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TNFR1 signaling, Regulation of innate immune responses to cytosolic DNA, STAT6-mediated induction of chemokines, STING mediated induction of host immune responses, Selective autophagy, Signal Transduction, Signaling by Interleukins, TNF signaling, TNFR1-induced proapoptotic signaling, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: Q9WUN2
Entrez ID: 56480
|
Does Knockout of Nit1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Nit1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Nit1 (nitrilase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: [acetyl-CoA carboxylase]-phosphatase activity, deaminated glutathione amidase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; CC: cytoplasm, mitochondrion
Pathways:
UniProt: Q8VDK1
Entrez ID: 27045
|
Does Knockout of Lrrc26 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Lrrc26
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lrrc26 (leucine rich repeat containing 26)
Type: protein-coding
Summary: Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRRC26 (leucine rich repeat containing 26). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport; MF: potassium channel activator activity, potassium channel regulator activity, transmembrane transporter binding, voltage-gated potassium channel activity; CC: cytoplasm, cytoskeleton, membrane, plasma membrane, voltage-gated potassium channel complex
Pathways:
UniProt: Q91W20
Entrez ID: 227618
|
Does Knockout of Ndufb11 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Ndufb11
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ndufb11 (NADH:ubiquinone oxidoreductase subunit B11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: O09111
Entrez ID: 104130
|
Does Knockout of Hacd4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Hacd4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hacd4 (3-hydroxyacyl-CoA dehydratase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid elongation, fatty acid metabolic process, lipid metabolic process, sphingolipid biosynthetic process, very long-chain fatty acid biosynthetic process; MF: 3-hydroxyacyl-CoA dehydratase activity, enzyme binding, lyase activity, very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs
UniProt: A2AKM2
Entrez ID: 66775
|
Does Knockout of Gpr31b in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Gpr31b
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Gpr31b (G protein-coupled receptor 31, D17Leh66b region)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, negative regulation of inflammatory response, positive regulation of immune response, response to acidic pH, response to ischemia, response to molecule of bacterial origin, signal transduction; MF: G protein-coupled receptor activity, arachidonate binding, bioactive lipid receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Free fatty acid receptors, G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Signal Transduction, Signaling by GPCR
UniProt: F8VQN3
Entrez ID: 436440
|
Does Knockout of Slc35a1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Slc35a1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc35a1 (solute carrier family 35 (CMP-sialic acid transporter), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP-N-acetylneuraminate biosynthetic process, CMP-N-acetylneuraminate transmembrane transport, N-acetylneuraminate metabolic process, pyrimidine nucleotide-sugar transmembrane transport; MF: CMP-N-acetylneuraminate transmembrane transporter activity, antiporter activity, pyrimidine nucleotide-sugar transmembrane transporter activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, DAG1 glycosylations, Matriglycan biosynthesis on DAG1, Metabolism of proteins, O-linked glycosylation, Post-translational protein modification, SLC-mediated transmembrane transport, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis, Transport of nucleotide sugars, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q61420
Entrez ID: 24060
|
Does Knockout of Bean1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Bean1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Bean1 (brain expressed, associated with Nedd4, 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways: Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q9EQG5
Entrez ID: 65115
|
Does Knockout of Rfc4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Rfc4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Rfc4 (replication factor C (activator 1) 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA clamp loader activity, enzyme binding, nucleotide binding, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, Elg1 RFC-like complex, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q99J62
Entrez ID: 106344
|
Does Knockout of Atf7ip in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Atf7ip
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Atf7ip (activating transcription factor 7 interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: ATP hydrolysis activity, transcription coregulator activity, transcription corepressor activity; CC: cytosol, nuclear body, nucleoplasm, nucleus, transcription regulator complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation of gene expression, Gene expression (Transcription), PKMTs methylate histone lysines, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: Q7TT18
Entrez ID: 54343
|
Does Knockout of Tarbp1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Tarbp1
|
cell cycle progression
|
breast epithelium
|
Gene: Tarbp1 (TAR RNA binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, methylation, tRNA methylation; MF: RNA binding, RNA methyltransferase activity, methyltransferase activity, tRNA (guanine(18)-2'-O)-methyltransferase activity, tRNA (guanine) methyltransferase activity, transferase activity
Pathways:
UniProt: E9Q368
Entrez ID: 212728
|
Does Knockout of 1700020A23Rik in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
1700020A23Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 1700020A23Rik (RIKEN cDNA 1700020A23 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q9DA59
Entrez ID: 75656
|
Does Knockout of Gulo in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Gulo
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gulo (gulonolactone (L-) oxidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-ascorbic acid biosynthetic process; MF: D-arabinono-1,4-lactone oxidase activity, FAD binding, L-gulonolactone oxidase activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), L-ascorbate biosynthesis VI
UniProt: P58710
Entrez ID: 268756
|
Does Knockout of Spag11a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Spag11a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Spag11a (sperm associated antigen 11A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antifungal humoral response, defense response, defense response to bacterium, negative regulation of interleukin-1 alpha production, negative regulation of interleukin-1 beta production, response to bacterium; CC: acrosomal vesicle, cell surface, extracellular region, extracellular space
Pathways:
UniProt: Q8K4N2
Entrez ID: 78128
|
Does Knockout of Mtmr3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Mtmr3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mtmr3 (myotubularin related protein 3)
Type: protein-coding
Summary: Predicted to enable phosphatase activity and protein phosphatase binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; phosphatidylinositol metabolic process; and regulation of phosphatidylinositol dephosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTMR3 (myotubularin related protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cellular response to glucose starvation, lipid metabolic process, midbody abscission, phosphatidylinositol 5-phosphate metabolic process, phosphatidylinositol biosynthetic process, phosphatidylinositol dephosphorylation, regulation of autophagosome assembly, regulation of phosphatidylinositol dephosphorylation; MF: hydrolase activity, metal ion binding, molecular adaptor activity, phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity, phosphatidylinositol-3-phosphate phosphatase activity, protein phosphatase binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, zinc ion binding; CC: cytoplasm, cytosol, membrane
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), D-<i>myo</i>-inositol-5-phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Macroautophagy, Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Synthesis of PIPs at the plasma membrane
UniProt: Q8K296
Entrez ID: 74302
|
Does Knockout of Abhd3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Abhd3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Abhd3 (abhydrolase domain containing 3)
Type: protein-coding
Summary: Predicted to enable carboxylic ester hydrolase activity. Involved in phosphatidylcholine metabolic process. Predicted to be located in membrane. Is expressed in several structures, including brain; genitourinary system; liver; olfactory epithelium; and spleen. Orthologous to human ABHD3 (abhydrolase domain containing 3, phospholipase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: lipid metabolic process, medium-chain fatty acid biosynthetic process, medium-chain fatty acid catabolic process, phosphatidylcholine metabolic process; MF: acetylesterase activity, carboxylic ester hydrolase activity, hydrolase activity, monoacylglycerol lipase activity, phospholipase A1 activity, phospholipase A2 activity; CC: cellular_component, membrane
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PC
UniProt: Q91ZH7
Entrez ID: 106861
|
Does Knockout of Atg5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 2,142
|
Knockout
|
Atg5
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Atg5 (autophagy related 5)
Type: protein-coding
Summary: The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: aggrephagy, antigen processing and presentation of endogenous antigen, apoptotic process, autophagosome assembly, autophagy, axonal transport, blood vessel remodeling, cellular response to nitrogen starvation, cellular response to nitrosative stress, cellular response to starvation, chaperone-mediated autophagy, chromatin organization, defense response to virus, establishment of localization in cell, heart contraction, immune system process, innate immune response, macroautophagy, mitophagy, negative regulation of apoptotic process, negative regulation of autophagic cell death, negative regulation of cardiac muscle cell apoptotic process, negative regulation of defense response to virus, negative regulation of innate immune response, negative regulation of phagocytosis, negative regulation of protein ubiquitination, negative regulation of type I interferon production, negative stranded viral RNA replication, negative thymic T cell selection, otolith development, piecemeal microautophagy of the nucleus, positive regulation of autophagy, positive regulation of mucus secretion, positive regulation of stress granule assembly, positive regulation of viral translation, post-translational protein modification, postsynaptic modulation of chemical synaptic transmission, regulation of autophagosome maturation, regulation of cilium assembly, regulation of cytokine production involved in immune response, regulation of organelle assembly, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of reactive oxygen species metabolic process, regulation of release of sequestered calcium ion into cytosol, response to fluoride, response to fungus, response to iron(II) ion, response to xenobiotic stimulus, vasodilation, ventricular cardiac muscle cell development; MF: Atg8-family ligase activity, protein binding; CC: Atg12-Atg5-Atg16 complex, Schaffer collateral - CA1 synapse, autophagosome, axon, axoneme, cytoplasm, cytosol, glutamatergic synapse, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, phagophore, phagophore assembly site membrane, postsynapse, protein-containing complex, synapse, transferase complex
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Ferroptosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Macroautophagy, Mitophagy, Mitophagy - animal - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), PINK1-PRKN Mediated Mitophagy, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Receptor Mediated Mitophagy, Selective autophagy
UniProt: Q99J83
Entrez ID: 11793
|
Does Knockout of Trim34b in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Trim34b
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Trim34b (tripartite motif-containing 34B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, innate immune response, protein ubiquitination, regulation of gene expression; MF: identical protein binding, metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, mitochondrion
Pathways:
UniProt: K7N6K2
Entrez ID: 434218
|
Does Knockout of Pir in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Pir
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Pir (pirin)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity; quercetin 2,3-dioxygenase activity; and transcription coregulator activity. Acts upstream of or within myeloid cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer; choroid plexus; and cortical plate. Orthologous to human PIR (pirin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: monocyte differentiation, myeloid cell differentiation; MF: dioxygenase activity, metal ion binding, oxidoreductase activity, quercetin 2,3-dioxygenase activity, transcription coregulator activity; CC: cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Digestion, Digestion and absorption
UniProt: Q9D711
Entrez ID: 69656
|
Does Knockout of Uts2r in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Uts2r
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Uts2r (urotensin 2 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, blood circulation, blood vessel diameter maintenance, negative regulation of blood pressure, negative regulation of glomerular filtration, negative regulation of urine volume, neuropeptide signaling pathway, positive regulation of angiogenesis, positive regulation of blood pressure, positive regulation of cell growth, positive regulation of circadian sleep/wake cycle, REM sleep, positive regulation of circadian sleep/wake cycle, wakefulness, positive regulation of cytosolic calcium ion concentration, positive regulation of fibroblast proliferation, positive regulation of vasoconstriction, regulation of blood pressure, signal transduction; MF: G protein-coupled receptor activity, urotensin II receptor activity; CC: early endosome, membrane, plasma membrane, recycling endosome
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q8VIH9
Entrez ID: 217369
|
Does Knockout of Kcnk12 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Kcnk12
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kcnk12 (potassium channel, subfamily K, member 12)
Type: protein-coding
Summary: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be active in plasma membrane. Orthologous to human KCNK12 (potassium two pore domain channel subfamily K member 12). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport; MF: identical protein binding, metal ion binding, outward rectifier potassium channel activity, potassium channel activity, potassium ion leak channel activity, protein heterodimerization activity; CC: endoplasmic reticulum membrane, membrane, monoatomic ion channel complex, plasma membrane
Pathways: Cardiac conduction, Muscle contraction, Phase 4 - resting membrane potential
UniProt: Q76M80
Entrez ID: 210741
|
Does Knockout of Kcng3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Kcng3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Kcng3 (potassium voltage-gated channel, subfamily G, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of potassium ion transmembrane transport, regulation of potassium ion transport, transmembrane transport; MF: monoatomic ion channel activity, potassium channel activity, potassium channel regulator activity, voltage-gated potassium channel activity; CC: cytoplasm, endoplasmic reticulum, membrane, monoatomic ion channel complex, plasma membrane, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: P59053
Entrez ID: 225030
|
Does Knockout of Mrps33 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Mrps33
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mrps33 (mitochondrial ribosomal protein S33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D2R8
Entrez ID: 14548
|
Does Knockout of Plpp5 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Plpp5
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Plpp5 (phospholipid phosphatase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, phospholipid dephosphorylation, phospholipid metabolic process; MF: diacylglycerol diphosphate phosphatase activity, hydrolase activity, phosphatidate phosphatase activity; CC: membrane, plasma membrane
Pathways: Fcgamma receptor (FCGR) dependent phagocytosis, Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid metabolism - Mus musculus (mouse), Immune System, Innate Immune System, Role of phospholipids in phagocytosis
UniProt: Q3UMZ3
Entrez ID: 71910
|
Does Knockout of Patz1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Patz1
|
cell cycle progression
|
breast epithelium
|
Gene: Patz1 (POZ (BTB) and AT hook containing zinc finger 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, male gonad development, negative regulation of DNA-templated transcription, negative regulation of endothelial cell migration, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of cytokine production, regulation of gene expression, regulation of immune system process, spermatogenesis; MF: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, metal ion binding, protein binding, ubiquitin protein ligase binding, zinc ion binding; CC: male germ cell nucleus, nucleoplasm, nucleus
Pathways:
UniProt: Q5NBY9
Entrez ID: 56218
|
Does Knockout of Sirt1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Sirt1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sirt1 (sirtuin 1)
Type: protein-coding
Summary: This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: DNA damage response, DNA repair-dependent chromatin remodeling, DNA synthesis involved in DNA repair, UV-damage excision repair, angiogenesis, apoptotic process, attachment of mitotic spindle microtubules to kinetochore, behavioral response to starvation, cardiac muscle cell apoptotic process, cell differentiation, cellular response to amyloid-beta, cellular response to glucose starvation, cellular response to hydrogen peroxide, cellular response to hypoxia, cellular response to ionizing radiation, cellular response to leukemia inhibitory factor, cellular response to resveratrol, cellular response to starvation, cellular response to tumor necrosis factor, cholesterol homeostasis, chromatin organization, circadian regulation of gene expression, circadian rhythm, endoplasmic reticulum unfolded protein response, energy homeostasis, fatty acid homeostasis, gluconeogenesis, heterochromatin formation, hippo signaling, intracellular glucose homeostasis, intracellular triglyceride homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, leptin-mediated signaling pathway, macrophage differentiation, maintenance of nucleus location, muscle organ development, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of DNA-templated transcription, negative regulation of NF-kappaB transcription factor activity, negative regulation of TOR signaling, negative regulation of androgen receptor signaling pathway, negative regulation of apoptotic process, negative regulation of attachment of mitotic spindle microtubules to kinetochore, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell cycle, negative regulation of cellular response to testosterone stimulus, negative regulation of cellular senescence, negative regulation of fat cell differentiation, negative regulation of fibroblast apoptotic process, negative regulation of gene expression, negative regulation of growth hormone secretion, negative regulation of hippo signaling, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of neuron apoptotic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of peptidyl-lysine acetylation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of phosphorylation, negative regulation of prostaglandin biosynthetic process, negative regulation of protein localization to nucleus, negative regulation of reactive oxygen species biosynthetic process, negative regulation of signal transduction by p53 class mediator, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of triglyceride biosynthetic process, negative regulation of tumor necrosis factor production, neuron apoptotic process, ovulation from ovarian follicle, positive regulation of DNA repair, positive regulation of MHC class II biosynthetic process, positive regulation of adaptive immune response, positive regulation of adipose tissue development, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of blood vessel endothelial cell migration, positive regulation of cAMP-dependent protein kinase activity, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of cell population proliferation, positive regulation of cellular senescence, positive regulation of cholesterol efflux, positive regulation of double-strand break repair, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of endothelial cell proliferation, positive regulation of gluconeogenesis, positive regulation of heart rate, positive regulation of insulin receptor signaling pathway, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of macroautophagy, positive regulation of macrophage apoptotic process, positive regulation of macrophage cytokine production, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein phosphorylation, positive regulation of skeletal muscle cell proliferation, positive regulation of smooth muscle cell differentiation, positive regulation of thyroid-stimulating hormone secretion, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein deacetylation, protein depropionylation, protein destabilization, protein ubiquitination, pyrimidine dimer repair by nucleotide-excision repair, rDNA heterochromatin formation, regulation of apoptotic process, regulation of bile acid biosynthetic process, regulation of brown fat cell differentiation, regulation of cell population proliferation, regulation of centrosome duplication, regulation of endodeoxyribonuclease activity, regulation of glucose metabolic process, regulation of lipid storage, regulation of mitotic cell cycle, regulation of multicellular organismal process, regulation of peroxisome proliferator activated receptor signaling pathway, regulation of smooth muscle cell apoptotic process, regulation of transcription by glucose, response to ethanol, response to hydrogen peroxide, response to insulin, response to leptin, response to oxidative stress, rhythmic process, signal transduction by p53 class mediator, single strand break repair, spermatogenesis, stress-induced premature senescence, subtelomeric heterochromatin formation, transforming growth factor beta receptor signaling pathway, tricarboxylic acid metabolic process, triglyceride biosynthetic process, triglyceride mobilization, vasodilation, white fat cell differentiation; MF: DNA-binding transcription factor binding, HLH domain binding, NAD+ binding, NAD-dependent protein decrotonylase activity, NAD-dependent protein lysine deacetylase activity, NAD-dependent protein lysine delactylase activity, NAD-dependent protein-lysine depropionylase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, bHLH transcription factor binding, deacetylase activity, enzyme activator activity, enzyme binding, enzyme inhibitor activity, histone H3K deacetylase activity, histone H3K14 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, NAD-dependent, histone H4K12 deacetylase activity, hydrolytic mechanism, histone H4K16 deacetylase activity, NAD-dependent, histone binding, histone deacetylase activity, histone deacetylase activity, NAD-dependent, histone decrotonylase activity, NAD-dependent, identical protein binding, keratin filament binding, metal ion binding, mitogen-activated protein kinase binding, nuclear receptor binding, p53 binding, promoter-specific chromatin binding, protein binding, protein domain specific binding, protein kinase B binding, protein lysine deacetylase activity, transcription coactivator activity, transcription corepressor activity, transcription regulator inhibitor activity, transferase activity; CC: ESC/E(Z) complex, PML body, axon, chromatin, chromatin silencing complex, chromosome, telomeric region, cytoplasm, cytosol, eNoSc complex, euchromatin, fibrillar center, growth cone, heterochromatin, mitochondrion, nuclear envelope, nuclear inner membrane, nucleolus, nucleoplasm, nucleus, protein-containing complex, rDNA heterochromatin
Pathways: AMPK signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Developmental Biology, FOXO-mediated transcription, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MITF-M-regulated melanocyte development, MicroRNAs in cancer - Mus musculus (mouse), Nicotinate and nicotinamide metabolism - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of FOXO transcriptional activity by acetylation, Regulation of HSF1-mediated heat shock response, Transcriptional and post-translational regulation of MITF-M expression and activity
UniProt: Q923E4
Entrez ID: 93759
|
Does Knockout of Actl6a in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,558
|
Knockout
|
Actl6a
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Actl6a (actin-like 6A)
Type: protein-coding
Summary: Enables chromatin binding activity. Involved in several processes, including positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Acts upstream of or within blastocyst formation and chromatin remodeling. Located in nucleus. Part of SWI/SNF complex and npBAF complex. Is expressed in several structures, including central nervous system; genitourinary system; lung; nose; and tooth. Orthologous to human ACTL6A (actin like 6A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, blastocyst formation, chromatin organization, chromatin remodeling, negative regulation of cell differentiation, nervous system development, neural retina development, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of double-strand break repair via homologous recombination, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, positive regulation of telomere maintenance in response to DNA damage, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of apoptotic process, regulation of cell cycle, regulation of chromosome organization, regulation of double-strand break repair, regulation of embryonic development, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, spinal cord development, system development, telomere maintenance; MF: chromatin binding, protein binding; CC: GBAF complex, Ino80 complex, NuA4 histone acetyltransferase complex, RSC-type complex, SWI/SNF complex, brahma complex, chromatin, kinetochore, npBAF complex, nuclear matrix, nucleoplasm, nucleosome, nucleus, plasma membrane
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Hepatocellular carcinoma - Mus musculus (mouse), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1, UCH proteinases
UniProt: Q9Z2N8
Entrez ID: 56456
|
Does Knockout of Slc17a9 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Slc17a9
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Slc17a9 (solute carrier family 17, member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ADP transport, ATP export, ATP transport, guanine nucleotide transmembrane transport, lysosomal protein catabolic process, purine nucleotide import into lysosome, purine-containing compound transmembrane transport, transmembrane transport; MF: ADP transmembrane transporter activity, ATP transmembrane transporter activity, guanine nucleotide transmembrane transporter activity, purine nucleotide uniporter activity, transmembrane transporter activity; CC: chromaffin granule membrane, cytoplasmic vesicle, lysosomal membrane, lysosome, membrane, mucin granule, secretory granule, transport vesicle membrane
Pathways:
UniProt: Q8VCL5
Entrez ID: 228993
|
Does Knockout of Anln in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Anln
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Anln (anillin, actin binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actomyosin contractile ring assembly, cell division, hematopoietic progenitor cell differentiation, mitotic cytokinesis, podocyte cell migration, positive regulation of bleb assembly, septin ring organization; MF: actin binding, protein binding; CC: actin cytoskeleton, actomyosin contractile ring, bleb, cell cortex, cell projection, cytoplasm, cytoskeleton, midbody, nucleoplasm, nucleus
Pathways: RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8K298
Entrez ID: 68743
|
Does Knockout of Rb1cc1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Rb1cc1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Rb1cc1 (RB1-inducible coiled-coil 1)
Type: protein-coding
Summary: Enables protein kinase binding activity. Involved in autophagosome assembly; negative regulation of cell population proliferation; and positive regulation of autophagy. Acts upstream of or within several processes, including defense response to other organism; positive regulation of cell size; and regulation of signal transduction. Located in autophagosome membrane; nucleus; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including cerebral cortex; ganglia; musculoskeletal system; oocyte; and trunk paraxial mesenchyme. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RB1CC1 (RB1 inducible coiled-coil 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: autophagosome assembly, autophagy, autophagy of mitochondrion, defense response to virus, glycophagy, heart development, innate immune response, liver development, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of extrinsic apoptotic signaling pathway, pexophagy, piecemeal microautophagy of the nucleus, positive regulation of JNK cascade, positive regulation of autophagy, positive regulation of cell size, reticulophagy, ribophagy; MF: molecular adaptor activity, protein binding, protein kinase binding, protein-membrane adaptor activity; CC: Atg1/ULK1 kinase complex, autophagosome membrane, cytoplasm, cytosol, lysosome, nuclear membrane, nucleus, organelle membrane, phagophore assembly site, phagophore assembly site membrane, vacuole
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Macroautophagy, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q9ESK9
Entrez ID: 12421
|
Does Knockout of Pitrm1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Pitrm1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pitrm1 (pitrilysin metallepetidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein processing, proteolysis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: mitochondrial matrix, mitochondrion
Pathways: Mitochondrial protein import, Protein localization
UniProt: Q8K411
Entrez ID: 69617
|
Does Knockout of Hivep2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Hivep2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hivep2 (human immunodeficiency virus type I enhancer binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, signal transduction; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q3UHF7
Entrez ID: 15273
|
Does Knockout of Omt2b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Omt2b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Omt2b (oocyte maturation, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytosol, membrane
Pathways:
UniProt: A0A087WRQ7, D3YX29, A0A087WQL0
Entrez ID: 382088
|
Does Knockout of Glo1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Glo1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Glo1 (glyoxalase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutathione metabolic process, methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione, methylglyoxal metabolic process, negative regulation of apoptotic process, osteoclast differentiation, regulation of transcription by RNA polymerase II; MF: lactoylglutathione lyase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytosol, nucleoplasm, plasma membrane
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), methylglyoxal degradation I
UniProt: Q9CPU0
Entrez ID: 109801
|
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