prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Nell2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Nell2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nell2 (NEL-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: commissural neuron axon guidance, development of secondary female sexual characteristics, fertilization, neurogenesis, neuron cellular homeostasis, positive regulation of hormone secretion, regulation of growth; MF: calcium ion binding, heparin binding, identical protein binding, metal ion binding, protein binding, protein kinase C binding; CC: cytoplasm, dendrite, extracellular region, extracellular space, perikaryon
Pathways:
UniProt: Q61220
Entrez ID: 54003
|
Does Knockout of Utp15 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Utp15
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Utp15 (UTP15 small subunit processome component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; CC: cytoplasm, endoplasmic reticulum, fibrillar center, nucleolus, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8C7V3
Entrez ID: 105372
|
Does Knockout of Actr2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Actr2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Actr2 (actin related protein 2)
Type: protein-coding
Summary: Predicted to enable cytoskeletal protein binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Acts upstream of or within several processes, including cellular response to type II interferon; meiotic chromosome movement towards spindle pole; and meiotic cytokinesis. Located in actin cap. Is expressed in cochlea and metanephros. Orthologous to human ACTR2 (actin related protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin cytoskeleton organization, asymmetric cell division, cellular response to type II interferon, cilium assembly, cytosolic transport, establishment or maintenance of cell polarity, meiotic cell cycle, meiotic chromosome movement towards spindle pole, meiotic cytokinesis, positive regulation of dendritic spine morphogenesis, positive regulation of double-strand break repair via homologous recombination, positive regulation of lamellipodium assembly, positive regulation of transcription by RNA polymerase II, regulation of double-strand break repair via nonhomologous end joining, spindle localization; MF: ATP binding, actin binding, actin filament binding, cytoskeletal protein binding, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, actin cap, cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, lamellipodium, nucleus, podosome core, postsynapse, site of double-strand break
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Membrane Trafficking, Nervous system development, Neutrophil degranulation, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: P61161
Entrez ID: 66713
|
Does Knockout of Trpm7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Trpm7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Trpm7 (transient receptor potential cation channel, subfamily M, member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actomyosin structure organization, calcium ion transmembrane transport, calcium ion transport, calcium-dependent cell-matrix adhesion, intracellular magnesium ion homeostasis, magnesium ion homeostasis, magnesium ion transmembrane transport, magnesium ion transport, memory, metal ion transport, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, necroptotic process, positive regulation of apoptotic process, programmed cell death, protein autophosphorylation, protein homotetramerization, protein tetramerization, transmembrane transport, zinc ion transmembrane transport, zinc ion transport; MF: ATP binding, actin binding, calcium channel activity, kinase activity, magnesium ion transmembrane transporter activity, metal ion binding, monoatomic cation channel activity, monoatomic ion channel activity, myosin binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, zinc ion transmembrane transporter activity; CC: cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, neuronal cell body, nucleus, plasma membrane, ruffle, synaptic vesicle membrane, varicosity
Pathways: Cellular senescence - Mus musculus (mouse), Ion channel transport, Mineral absorption - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q923J1
Entrez ID: 58800
|
Does Knockout of Rhbdf1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Rhbdf1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rhbdf1 (rhomboid 5 homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, cell population proliferation, negative regulation of protein secretion, regulation of epidermal growth factor receptor signaling pathway, regulation of proteasomal protein catabolic process, regulation of protein secretion; CC: Golgi apparatus, Golgi membrane, cytoplasm, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q6PIX5
Entrez ID: 13650
|
Does Knockout of Hr in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Hr
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hr (Hr, lysine demethylase and nuclear receptor corepressor)
Type: protein-coding
Summary: This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory ORF that exists upstream of the primary ORF. Mutations in this upstream ORF, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss in human. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: chromatin remodeling, negative regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, chromatin DNA binding, histone H3K9 demethylase activity, histone H3K9me/H3K9me2 demethylase activity, histone deacetylase binding, metal ion binding, nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, oxidoreductase activity, protein binding, protein-containing complex binding, transcription coregulator activity, transcription corepressor activity, zinc ion binding; CC: chromatin, histone deacetylase complex, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q61645
Entrez ID: 15460
|
Does Knockout of Erp44 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Erp44
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Erp44 (endoplasmic reticulum protein 44)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycoprotein metabolic process, protein folding, response to endoplasmic reticulum stress, response to unfolded protein; MF: protein binding, protein disulfide isomerase activity; CC: cell surface, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q9D1Q6
Entrez ID: 76299
|
Does Knockout of Syap1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Syap1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Syap1 (synapse associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC2 signaling, cell differentiation, cellular response to epidermal growth factor stimulus, cellular response to insulin stimulus, cellular response to insulin-like growth factor stimulus, cellular response to platelet-derived growth factor stimulus, positive regulation of fat cell differentiation, positive regulation of protein serine/threonine kinase activity, regulation of short-term neuronal synaptic plasticity; CC: Golgi apparatus, axon, cell projection, cytoplasm, cytoplasmic side of plasma membrane, cytosol, dendrite, growth cone, membrane, nucleoplasm, nucleus, perikaryon, perinuclear region of cytoplasm, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse
Pathways:
UniProt: Q9D5V6
Entrez ID: 67043
|
Does Knockout of Naa50 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Naa50
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Naa50 (N(alpha)-acetyltransferase 50, NatE catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-terminal protein amino acid acetylation, chromatin remodeling, establishment of mitotic sister chromatid cohesion, mitotic sister chromatid cohesion, mitotic sister chromatid cohesion, centromeric, post-translational protein modification; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, histone H4 acetyltransferase activity, protein N-terminal-methionine acetyltransferase activity, protein binding, protein-N-terminal amino-acid acetyltransferase activity, protein-lysine-acetyltransferase activity, transferase activity; CC: NatA complex, cytoplasm, cytosol, nucleolus, nucleus
Pathways:
UniProt: Q6PGB6
Entrez ID: 72117
|
Does Knockout of Cox8a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Cox8a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cox8a (cytochrome c oxidase subunit 8A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, aerobic respiration -- electron donor II
UniProt: Q64445
Entrez ID: 12868
|
Does Knockout of Ucn in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Ucn
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Ucn (urocortin)
Type: protein-coding
Summary: This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit a heightened anxiety-like behaviors and a significantly reduced acoustic startle response. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: aerobic respiration, associative learning, drinking behavior, feeding behavior, female pregnancy, learning or memory, negative regulation of apoptotic process, negative regulation of appetite, negative regulation of blood pressure, negative regulation of cell size, negative regulation of feeding behavior, negative regulation of gene expression, negative regulation of hormone secretion, negative regulation of neuron apoptotic process, neuron projection development, neuropeptide signaling pathway, positive regulation of DNA replication, positive regulation of behavioral fear response, positive regulation of cAMP/PKA signal transduction, positive regulation of calcium ion import, positive regulation of cardiac muscle contraction, positive regulation of cell growth, positive regulation of collagen biosynthetic process, positive regulation of corticotropin secretion, positive regulation of gene expression, positive regulation of interleukin-6 production, positive regulation of transcription by RNA polymerase II, positive regulation of translation, positive regulation of vascular permeability, prepulse inhibition, regulation of synaptic transmission, glutamatergic, response to auditory stimulus, response to estradiol, response to glucocorticoid, response to immobilization stress, response to oxidative stress, response to pain, response to starvation, sensory perception of sound, social behavior, startle response, vasodilation; MF: G protein-coupled receptor binding, corticotropin-releasing hormone receptor 1 binding, corticotropin-releasing hormone receptor 2 binding, histone deacetylase inhibitor activity, hormone activity; CC: axon, axon terminus, dendrite, extracellular region, neuronal cell body, perikaryon, varicosity
Pathways: Class B/2 (Secretin family receptors), GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P81615
Entrez ID: 22226
|
Does Knockout of Chchd2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Chchd2
|
cell cycle progression
|
breast epithelium
|
Gene: Chchd2 (coiled-coil-helix-coiled-coil-helix domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress, mitochondrion organization, positive regulation of mitochondrial ATP synthesis coupled electron transport, positive regulation of transcription by RNA polymerase II, regulation of cellular response to hypoxia, regulation of generation of precursor metabolites and energy; MF: DNA-binding transcription factor binding, sequence-specific DNA binding; CC: mitochondrial intermembrane space, mitochondrion, nucleus
Pathways:
UniProt: Q9D1L0
Entrez ID: 14004
|
Does Knockout of Vsig1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Vsig1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vsig1 (V-set and immunoglobulin domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial cell morphogenesis, maintenance of gastrointestinal epithelium; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q9D2J4
Entrez ID: 78789
|
Does Knockout of Gps2 in Malignant Peripheral Nerve Sheath Tumor (MPNST) cancer cell causally result in cell proliferation?
| 1
| 2,182
|
Knockout
|
Gps2
|
cell proliferation
|
Malignant Peripheral Nerve Sheath Tumor (MPNST) cancer cell
|
Gene: Gps2 (G protein pathway suppressor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, negative regulation of B cell receptor signaling pathway, negative regulation of JNK cascade, negative regulation of fat cell differentiation, negative regulation of inflammatory response, negative regulation of protein K63-linked ubiquitination, negative regulation of toll-like receptor signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of cholesterol efflux, positive regulation of peroxisome proliferator activated receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of fat cell differentiation, regulation of lipid metabolic process, regulation of transcription by RNA polymerase II, response to mitochondrial depolarisation; MF: cyclin binding, protein binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), HDACs deacetylate histones, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q921N8
Entrez ID: 56310
|
Does Knockout of Pramel6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Pramel6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pramel6 (PRAME like 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q810Y9
Entrez ID: 347711
|
Does Knockout of Mtnr1b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Mtnr1b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mtnr1b (melatonin receptor 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, circadian rhythm, glucose homeostasis, negative regulation of cGMP-mediated signaling, negative regulation of cytosolic calcium ion concentration, negative regulation of insulin secretion, negative regulation of neuron apoptotic process, negative regulation of transmission of nerve impulse, negative regulation of vasoconstriction, positive regulation of circadian rhythm, positive regulation of circadian sleep/wake cycle, non-REM sleep, positive regulation of transmission of nerve impulse, regulation of insulin secretion, regulation of neuronal action potential, signal transduction; MF: G protein-coupled receptor activity, melatonin receptor activity; CC: membrane, plasma membrane
Pathways: Circadian entrainment - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse)
UniProt: Q3SXF8
Entrez ID: 244701
|
Does Knockout of Acly in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,286
|
Knockout
|
Acly
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Acly (ATP citrate lyase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetyl-CoA biosynthetic process, acetyl-CoA metabolic process, acyl-CoA biosynthetic process, citrate metabolic process, fatty acid biosynthetic process, lipid biosynthetic process, lipid metabolic process, malonyl-CoA biosynthetic process, negative regulation of ferroptosis, oxaloacetate metabolic process; MF: ATP binding, ATP citrate synthase activity, acyltransferase activity, acyl groups converted into alkyl on transfer, catalytic activity, metal ion binding, nucleotide binding, protein binding, transferase activity; CC: ciliary basal body, cytoplasm, cytosol, mitochondrion, nucleoplasm
Pathways: Citrate cycle (TCA cycle) - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Immune System, Innate Immune System, Metabolism, Metabolism of lipids, Neutrophil degranulation, acetyl-CoA biosynthesis (from citrate), superpathway of acetyl-CoA biosynthesis
UniProt: Q91V92
Entrez ID: 104112
|
Does Knockout of 4930407I10Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
4930407I10Rik
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: 4930407I10Rik (RIKEN cDNA 4930407I10 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D3Z5T8
Entrez ID: 328573
|
Does Knockout of Ctag2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Ctag2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ctag2 (cancer/testis antigen 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA processing, tRNA threonylcarbamoyladenosine metabolic process; CC: EKC/KEOPS complex, cytoplasm, nucleus
Pathways:
UniProt: Q9D9S4
Entrez ID: 70062
|
Does Knockout of Cxcr4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Cxcr4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cxcr4 (C-X-C motif chemokine receptor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CXCL12-activated CXCR4 signaling pathway, G protein-coupled receptor signaling pathway, T cell proliferation, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, ameboidal-type cell migration, animal organ morphogenesis, aorta development, blood vessel endothelial cell migration, brain development, branching involved in blood vessel morphogenesis, calcium-mediated signaling, cardiac muscle contraction, cell chemotaxis, cell migration, cellular response to cytokine stimulus, chemokine-mediated signaling pathway, chemotaxis, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, endothelial cell differentiation, endothelial tube morphogenesis, epithelial cell development, generation of neurons, germ cell development, germ cell migration, hematopoietic stem cell migration, immune response, kidney development, motor neuron axon guidance, myelin maintenance, myoblast migration, nervous system development, neural precursor cell proliferation, neurogenesis, neuron migration, positive regulation of ERK1 and ERK2 cascade, positive regulation of calcium ion import, positive regulation of cell migration, positive regulation of chemotaxis, positive regulation of cold-induced thermogenesis, positive regulation of cytosolic calcium ion concentration, positive regulation of dendrite extension, positive regulation of macrophage migration inhibitory factor signaling pathway, positive regulation of mesenchymal stem cell migration, positive regulation of neurogenesis, positive regulation of oligodendrocyte differentiation, positive regulation of vascular wound healing, positive regulation of vasculature development, regulation of calcium ion transport, regulation of cell adhesion, regulation of cell migration, regulation of chemotaxis, regulation of neuron migration, regulation of programmed cell death, regulation of viral process, response to tacrolimus, signal transduction, telencephalon cell migration, ventricular septum development; MF: C-C chemokine binding, C-C chemokine receptor activity, C-X-C chemokine receptor activity, C-X-C motif chemokine 12 receptor activity, G protein-coupled receptor activity, actin binding, chemokine receptor activity, cytokine binding, myosin light chain binding, protein binding, small molecule binding, ubiquitin binding, ubiquitin protein ligase binding; CC: anchoring junction, cell leading edge, cell surface, cell-cell junction, cytoplasmic vesicle, early endosome, endosome, external side of plasma membrane, growth cone, late endosome, lysosome, membrane, plasma membrane, protein-containing complex
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Developmental Biology, Endocytosis - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Intestinal immune network for IgA production - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Nervous system development, Pathways in cancer - Mus musculus (mouse), Peptide ligand-binding receptors, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Signaling by ROBO receptors, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P70658
Entrez ID: 12767
|
Does Knockout of Mxd3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Mxd3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mxd3 (Max dimerization protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity; CC: RNA polymerase II transcription regulator complex, nucleus
Pathways:
UniProt: Q80US8
Entrez ID: 17121
|
Does Knockout of Mtg1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Mtg1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mtg1 (mitochondrial ribosome-associated GTPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial large ribosomal subunit assembly, regulation of mitochondrial translation, regulation of respiratory system process, regulation of translation; MF: GTP binding, GTPase activity, nucleotide binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrion, nucleoplasm
Pathways: cyclic AMP biosynthesis
UniProt: Q8R2R6
Entrez ID: 212508
|
Does Knockout of Ttk in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ttk
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ttk (Ttk protein kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromosome segregation, female meiosis chromosome segregation, meiotic spindle assembly checkpoint signaling, mitotic spindle assembly checkpoint signaling, nuclear chromosome segregation, nuclear division, protein localization to chromosome, protein localization to kinetochore, protein localization to meiotic spindle midzone, repair of mitotic kinetochore microtubule attachment defect; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, kinetochore, membrane, nucleus
Pathways: Cell cycle - Mus musculus (mouse)
UniProt: P35761
Entrez ID: 22137
|
Does Knockout of Kank1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Kank1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Kank1 (KN motif and ankyrin repeat domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, cell population proliferation, cortical microtubule organization, negative regulation of Rho protein signal transduction, negative regulation of actin filament polymerization, negative regulation of cell migration, negative regulation of insulin receptor signaling pathway, negative regulation of lamellipodium morphogenesis, negative regulation of neuron projection development, negative regulation of ruffle assembly, negative regulation of substrate adhesion-dependent cell spreading, podocyte cell migration, positive regulation of Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of wound healing, regulation of Rho protein signal transduction, regulation of establishment of cell polarity; MF: beta-catenin binding, protein-macromolecule adaptor activity; CC: cell cortex, cell projection, cytoplasm, cytoskeleton, membrane, nucleus, plasma membrane, ruffle membrane
Pathways:
UniProt: E9Q238
Entrez ID: 107351
|
Does Knockout of Il22ra1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Il22ra1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Il22ra1 (interleukin 22 receptor, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, defense response to Gram-negative bacterium, interleukin-22-mediated signaling pathway, negative regulation of cytokine production involved in inflammatory response, negative regulation of inflammatory response, positive regulation of inflammatory response; MF: cytokine receptor activity, interleukin-20 binding, interleukin-22 receptor activity; CC: membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-20 family signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Signaling by Interleukins, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q80XZ4
Entrez ID: 230828
|
Does Knockout of Gm15013 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Gm15013
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm15013 (ribosomal protein S4, X-linked pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100417274
|
Does Knockout of Ago2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ago2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ago2 (argonaute RISC catalytic subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P-body assembly, RISC complex assembly, RNA stabilization, cell differentiation, gene expression, miRNA metabolic process, miRNA processing, miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated gene silencing by mRNA destabilization, negative regulation of amyloid precursor protein biosynthetic process, negative regulation of translational initiation, positive regulation of angiogenesis, positive regulation of gene expression, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of post-transcriptional gene silencing by RNA, positive regulation of transcription by RNA polymerase II, positive regulation of translation, positive regulation of trophoblast cell migration, post-embryonic development, pre-miRNA processing, regulation of DNA-templated transcription, regulation of mRNA stability, regulation of synapse maturation, regulation of translation, regulatory ncRNA-mediated gene silencing, regulatory ncRNA-mediated post-transcriptional gene silencing, siRNA processing, siRNA-mediated gene silencing by mRNA destabilization; MF: Hsp70 protein binding, Hsp90 protein binding, RISC complex binding, RNA 7-methylguanosine cap binding, RNA binding, RNA endonuclease activity, RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism, RNA polymerase II complex binding, core promoter sequence-specific DNA binding, double-stranded RNA binding, endonuclease activity, endoribonuclease activity, cleaving miRNA-paired mRNA, endoribonuclease activity, cleaving siRNA-paired mRNA, hydrolase activity, mRNA 3'-UTR AU-rich region binding, mRNA binding, mRNA cap binding, metal ion binding, miRNA binding, nuclease activity, nucleic acid binding, protein binding, siRNA binding, single-stranded RNA binding; CC: Golgi apparatus, P granule, P-body, RISC complex, RISC-loading complex, chromatoid body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, dendrite, extracellular exosome, glutamatergic synapse, membrane, mitochondrion, nucleus, pi-body, postsynapse, ribonucleoprotein complex
Pathways: Gene Silencing by RNA, Gene expression (Transcription), MicroRNA (miRNA) biogenesis, Post-transcriptional silencing by small RNAs, Small interfering RNA (siRNA) biogenesis, Transcriptional regulation by small RNAs
UniProt: Q8CJG0
Entrez ID: 239528
|
Does Knockout of Tff3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Tff3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tff3 (trefoil factor 3, intestinal)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Involved in regulation of glucose metabolic process. Located in secretory granule. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and sensory organ. Orthologous to human TFF3 (trefoil factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: maintenance of gastrointestinal epithelium, regulation of glucose metabolic process; MF: identical protein binding; CC: cytoplasm, extracellular region, extracellular space, secretory granule
Pathways:
UniProt: Q62395
Entrez ID: 21786
|
Does Knockout of Abcb1b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Abcb1b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Abcb1b (ATP-binding cassette, sub-family B member 1B)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, Sertoli cell barrier remodeling, adult heart development, aldosterone secretion, carboxylic acid transmembrane transport, ceramide translocation, epidermal growth factor receptor signaling pathway, establishment of endothelial blood-brain barrier, exploration behavior, export across plasma membrane, female gonad development, gene expression, lipid transport, neural tissue regeneration, neurogenesis, neuron differentiation, phospholipid translocation, proteasomal protein catabolic process, regulation of chloride transport, response to toxic substance, response to xenobiotic stimulus, stem cell proliferation, tissue homeostasis, transepithelial transport, transmembrane transport, xenobiotic detoxification by transmembrane export across the plasma membrane, xenobiotic transport, xenobiotic transport across blood-brain barrier; MF: ABC-type transporter activity, ABC-type xenobiotic transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, ATPase-coupled transmembrane transporter activity, carboxylic acid transmembrane transporter activity, ceramide floppase activity, efflux transmembrane transporter activity, floppase activity, nucleotide binding, phosphatidylcholine floppase activity, phosphatidylethanolamine flippase activity, ubiquitin protein ligase binding, xenobiotic transmembrane transporter activity; CC: Golgi membrane, apical plasma membrane, cell surface, cytoplasm, external side of apical plasma membrane, intercellular canaliculus, membrane, mitochondrion, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse), Bile secretion - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse)
UniProt: P06795
Entrez ID: 18669
|
Does Knockout of Las1l in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Las1l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Las1l (LAS1-like (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing; MF: endonuclease activity, hydrolase activity; CC: Las1 complex, MLL1 complex, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: A2BE28
Entrez ID: 76130
|
Does Knockout of Dad1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Dad1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dad1 (defender against cell death 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, blastocyst development, negative regulation of apoptotic process, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, regulation of protein stability; MF: enzyme activator activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, N-Glycan biosynthesis - Mus musculus (mouse), PD-L1(CD274) glycosylation and translocation to plasma membrane, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: P61804
Entrez ID: 13135
|
Does Knockout of Ugdh in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Ugdh
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ugdh (UDP-glucose dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: UDP-glucuronate biosynthetic process, chondroitin sulfate proteoglycan biosynthetic process, gastrulation with mouth forming second, glycosaminoglycan biosynthetic process, heparan sulfate proteoglycan biosynthetic process, neuron development, protein hexamerization; MF: NAD binding, UDP-glucose 6-dehydrogenase activity, catalytic activity, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: nucleoplasm, nucleus
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Ascorbate and aldarate metabolism - Mus musculus (mouse), Biological oxidations, Formation of the active cofactor, UDP-glucuronate, Glucuronidation, L-ascorbate biosynthesis VI, Metabolism, Pentose and glucuronate interconversions - Mus musculus (mouse), Phase II - Conjugation of compounds, UDP-D-xylose and UDP-D-glucuronate biosynthesis, colanic acid building blocks biosynthesis
UniProt: O70475
Entrez ID: 22235
|
Does Knockout of Fan1 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,545
|
Knockout
|
Fan1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Fan1 (FANCD2/FANCI-associated nuclease 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via homologous recombination, interstrand cross-link repair, nucleotide-excision repair; MF: 5'-3' exonuclease activity, 5'-flap endonuclease activity, DNA binding, endonuclease activity, exonuclease activity, flap-structured DNA binding, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding, nuclease activity, nucleic acid binding, phosphodiesterase I activity, ubiquitin-modified protein reader activity, zinc ion binding; CC: cilium, cytosol, intercellular bridge, nucleoplasm, nucleus
Pathways: DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse)
UniProt: Q69ZT1
Entrez ID: 330554
|
Does Knockout of Rrm2b in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Rrm2b
|
cell cycle progression
|
breast epithelium
|
Gene: Rrm2b (ribonucleotide reductase M2 B (TP53 inducible))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2'-deoxyribonucleotide biosynthetic process, DNA damage response, DNA repair, DNA synthesis involved in DNA repair, deoxyribonucleoside triphosphate metabolic process, deoxyribonucleotide biosynthetic process, kidney development, mitochondrial DNA replication, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of G0 to G1 transition, positive regulation of G2/M transition of mitotic cell cycle, renal system process, response to amine, response to oxidative stress, ribonucleoside diphosphate metabolic process; MF: identical protein binding, metal ion binding, oxidoreductase activity, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, ribonucleoside-diphosphate reductase complex
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Glutathione metabolism - Mus musculus (mouse), Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), adenosine nucleotides <i>de novo</i> biosynthesis, p53 signaling pathway - Mus musculus (mouse), pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis I
UniProt: Q6PEE3
Entrez ID: 382985
|
Does Knockout of Pole in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Pole
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pole (polymerase (DNA directed), epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA metabolic process, DNA repair, DNA replication, DNA replication proofreading, DNA synthesis involved in DNA repair, DNA-templated DNA replication, G1/S transition of mitotic cell cycle, base-excision repair, gap-filling, embryonic organ development, leading strand elongation, mitotic cell cycle, nucleotide-excision repair, DNA gap filling; MF: 4 iron, 4 sulfur cluster binding, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, chromatin binding, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, single-stranded DNA 3'-5' DNA exonuclease activity, transferase activity, zinc ion binding; CC: epsilon DNA polymerase complex, nucleoplasm, nucleus, plasma membrane
Pathways: Activation of the pre-replicative complex, Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Mus musculus (mouse), DNA replication initiation, Dual Incision in GG-NER, Dual incision in TC-NER, G1/S Transition, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Mitotic G1 phase and G1/S transition, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Recognition of DNA damage by PCNA-containing replication complex, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9WVF7
Entrez ID: 18973
|
Does Knockout of Gabpb1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Gabpb1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gabpb1 (GA repeat binding protein, beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrion organization, positive regulation of transcription by RNA polymerase II; MF: protein binding, transcription cis-regulatory region binding; CC: cytoplasmic ribonucleoprotein granule, nucleoplasm, nucleus
Pathways: Mitochondrial biogenesis, Organelle biogenesis and maintenance, Transcriptional activation of mitochondrial biogenesis
UniProt: Q00420
Entrez ID: 14391
|
Does Knockout of Dnaja1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Dnaja1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the DnaJ family, whose members act as cochaperones of heat shock protein 70. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. Mice deficient for this gene display reduced levels of activation‐induced deaminase, an enzyme that deaminates deoxycytidine at the immunoglobulin genes during immune responses. In addition, mice lacking this gene exhibit severe defects in spermatogenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: androgen receptor signaling pathway, flagellated sperm motility, negative regulation of JUN kinase activity, negative regulation of apoptotic process, negative regulation of establishment of protein localization to mitochondrion, negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway, negative regulation of protein ubiquitination, positive regulation of apoptotic process, protein folding, protein localization to mitochondrion, protein refolding, regulation of protein transport, response to heat, spermatogenesis; MF: ATP binding, ATPase activator activity, C3HC4-type RING finger domain binding, G protein-coupled receptor binding, Hsp70 protein binding, Tat protein binding, heat shock protein binding, low-density lipoprotein particle receptor binding, metal ion binding, protein binding, protein-folding chaperone binding, ubiquitin protein ligase binding, unfolded protein binding, zinc ion binding; CC: cytoplasm, cytosol, endoplasmic reticulum, membrane, microtubule cytoskeleton, mitochondrion, nucleus, perinuclear region of cytoplasm
Pathways: Cellular responses to stimuli, Cellular responses to stress, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Mitochondrial unfolded protein response (UPRmt), Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: P63037
Entrez ID: 15502
|
Does Knockout of Ociad1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ociad1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ociad1 (OCIA domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endosome, mitochondrion
Pathways:
UniProt: Q9CRD0
Entrez ID: 68095
|
Does Knockout of 4930590J08Rik in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
4930590J08Rik
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: 4930590J08Rik (RIKEN cDNA 4930590J08 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, membrane
Pathways:
UniProt: Q8CDN1
Entrez ID: 381798
|
Does Knockout of Brca2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Brca2
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Brca2 (breast cancer 2, early onset)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA recombination, DNA repair, brain development, cell population proliferation, cellular response to ionizing radiation, cellular senescence, centrosome duplication, chordate embryonic development, chromatin remodeling, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, establishment of protein localization to telomere, female gonad development, hematopoietic stem cell proliferation, hemopoiesis, homologous chromosome orientation in meiotic metaphase I, inner cell mass cell proliferation, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, male meiosis I, mammary gland development, meiosis I, mitotic recombination-dependent replication fork processing, multicellular organism growth, negative regulation of mammary gland epithelial cell proliferation, nucleotide-excision repair, oocyte maturation, positive regulation of DNA-templated transcription, positive regulation of mitotic cell cycle, regulation of DNA damage checkpoint, regulation of DNA-templated transcription, regulation of cytokinesis, replication fork processing, response to UV-C, response to X-ray, response to gamma radiation, spermatogenesis, stem cell proliferation, telomere maintenance via recombination; MF: DNA binding, gamma-tubulin binding, histone H3 acetyltransferase activity, histone H4 acetyltransferase activity, identical protein binding, protease binding, protein binding, single-stranded DNA binding; CC: BRCA2-MAGE-D1 complex, DNA repair complex, centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytoskeleton, cytosol, lateral element, nuclear ubiquitin ligase complex, nucleoplasm, nucleus, protein-containing complex, secretory granule
Pathways: Breast cancer - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through MMEJ (alt-NHEJ), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Presynaptic phase of homologous DNA pairing and strand exchange, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: P97929
Entrez ID: 12190
|
Does Knockout of Zfp146 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Zfp146
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Zfp146 (zinc finger protein 146)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: cytoplasm, cytosol, nucleolus, nucleus
Pathways:
UniProt: Q8BQN6
Entrez ID: 26465
|
Does Knockout of Nup43 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Nup43
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nup43 (nucleoporin 43)
Type: protein-coding
Summary: Predicted to be involved in nucleocytoplasmic transport. Predicted to be located in cytosol; nuclear envelope; and nuclear speck. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Is expressed in several structures, including gut; lung; olfactory epithelium; tooth; and urinary system. Orthologous to human NUP43 (nucleoporin 43). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, chromosome segregation, mRNA transport, nucleocytoplasmic transport, protein transport; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, nuclear envelope, nuclear pore, nuclear pore outer ring, nuclear speck, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: P59235
Entrez ID: 69912
|
Does Knockout of Orc1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Orc1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Orc1 (origin recognition complex, subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA replication initiation, mitotic DNA replication checkpoint signaling, positive regulation of G0 to G1 transition, positive regulation of smooth muscle cell proliferation; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA replication origin binding, chromatin binding, metal ion binding, nucleotide binding; CC: chromosome, telomeric region, nuclear origin of replication recognition complex, nucleoplasm, nucleus, origin recognition complex
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the ORC complex at the origin of replication, Assembly of the pre-replicative complex, CDC6 association with the ORC:origin complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: Q9Z1N2
Entrez ID: 18392
|
Does Knockout of Casz1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Casz1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Casz1 (castor zinc finger 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of amacrine cell differentiation, negative regulation of glial cell differentiation, negative regulation of neuron differentiation, negative regulation of retinal cone cell fate commitment, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, radial glial cell differentiation, regulation of DNA-templated transcription, regulation of neuron differentiation, retinal bipolar neuron differentiation, retinal rod cell fate commitment; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: chromatin, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9CWL2
Entrez ID: 69743
|
Does Knockout of Dmrtc1a in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Dmrtc1a
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Dmrtc1a (DMRT-like family C1a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding
Pathways:
UniProt: Q9D9R7
Entrez ID: 70887
|
Does Knockout of Dnajb6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Dnajb6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dnajb6 (DnaJ heat shock protein family (Hsp40) member B6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, chorio-allantoic fusion, chorion development, extracellular matrix organization, intermediate filament organization, negative regulation of DNA-templated transcription, negative regulation of inclusion body assembly, nervous system process, protein folding, protein localization to nucleus, regulation of protein localization, syncytiotrophoblast cell differentiation involved in labyrinthine layer development; MF: ATPase activator activity, DNA binding, Hsp70 protein binding, heat shock protein binding, identical protein binding, protein binding, protein folding chaperone, protein-folding chaperone binding, unfolded protein binding; CC: Z disc, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: O54946
Entrez ID: 23950
|
Does Knockout of Nyap2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Nyap2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Nyap2 (neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuron projection morphogenesis, phosphatidylinositol 3-kinase/protein kinase B signal transduction
Pathways:
UniProt: A0A0R4J1X0, A0A0R4J1I8, D3Z3N9
Entrez ID: 241134
|
Does Knockout of Scgb2b24 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Scgb2b24
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Scgb2b24 (secretoglobin, family 2B, member 24)
Type: protein-coding
Summary: Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, extracellular region, extracellular space
Pathways:
UniProt: Q7M747
Entrez ID: 233090
|
Does Knockout of Lyz1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Lyz1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lyz1 (lysozyme 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and lysozyme activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Predicted to be located in several cellular components, including Golgi cis cisterna; cytoplasmic vesicle; and rough endoplasmic reticulum lumen. Is expressed in embryo mesenchyme; intestine; liver and biliary system; and lung. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, killing of cells of another organism; MF: catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, identical protein binding, lysozyme activity; CC: Golgi cis cisterna, Golgi stack, endoplasmic reticulum lumen, extracellular region, extracellular space, microvillus, rough endoplasmic reticulum lumen, secretory granule, trans-Golgi network transport vesicle
Pathways: Salivary secretion - Mus musculus (mouse)
UniProt: P17897
Entrez ID: 17110
|
Does Knockout of Il6ra in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Il6ra
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Il6ra (interleukin 6 receptor, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 17 cell lineage commitment, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, ciliary neurotrophic factor-mediated signaling pathway, cytokine-mediated signaling pathway, developmental growth, developmental process, endocrine pancreas development, interleukin-11-mediated signaling pathway, interleukin-6-mediated signaling pathway, negative regulation of collagen biosynthetic process, positive regulation of MAPK cascade, positive regulation of cell population proliferation, positive regulation of chemokine production, positive regulation of glomerular mesangial cell proliferation, positive regulation of interleukin-6 production, positive regulation of platelet aggregation, positive regulation of smooth muscle cell proliferation, response to cytokine, vascular endothelial growth factor production; MF: ciliary neurotrophic factor binding, ciliary neurotrophic factor receptor activity, cytokine receptor activity, enzyme binding, interleukin-11 binding, interleukin-11 receptor activity, interleukin-6 binding, interleukin-6 receptor activity, interleukin-6 receptor binding, protein homodimerization activity; CC: apical plasma membrane, cell surface, ciliary neurotrophic factor receptor complex, external side of plasma membrane, extracellular region, extracellular space, interleukin-6 receptor complex, membrane, neuronal cell body membrane, plasma membrane, receptor complex
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Immune System, Interleukin-6 family signaling, Interleukin-6 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK1 (ERK2) activation, MAPK1/MAPK3 signaling, MAPK3 (ERK1) activation, Non-alcoholic fatty liver disease - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RAF-independent MAPK1/3 activation, Signal Transduction, Signaling by Interleukins, Th17 cell differentiation - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P22272
Entrez ID: 16194
|
Does Knockout of Klk1b24 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Klk1b24
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Klk1b24 (kallikrein 1-related peptidase b24)
Type: protein-coding
Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: proteolysis, regulation of systemic arterial blood pressure, zymogen activation; MF: endopeptidase activity, hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: acrosomal vesicle, apical part of cell, extracellular space, nucleus, secretory granule
Pathways: Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Extracellular matrix organization, Renin-angiotensin system - Mus musculus (mouse)
UniProt: Q61754
Entrez ID: 16617
|
Does Knockout of Top1 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Top1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Top1 (topoisomerase (DNA) I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA topological change, animal organ regeneration, cellular response to luteinizing hormone stimulus, chromatin remodeling, chromosome segregation, circadian regulation of gene expression, circadian rhythm, embryonic cleavage, rRNA transcription, response to cAMP, response to gamma radiation, response to temperature stimulus, response to xenobiotic stimulus, rhythmic process; MF: ATP binding, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, double-stranded DNA binding, isomerase activity, protein domain specific binding, protein serine/threonine kinase activity, protein-containing complex binding, single-stranded DNA binding, supercoiled DNA binding; CC: P-body, chromosome, cytoplasm, dense fibrillar component, fibrillar center, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, perikaryon, protein-DNA complex
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins
UniProt: Q04750
Entrez ID: 21969
|
Does Knockout of Grk4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Grk4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Grk4 (G protein-coupled receptor kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, desensitization of G protein-coupled receptor signaling pathway, receptor internalization, regulation of signal transduction, signal transduction; MF: ATP binding, G protein-coupled receptor kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, rhodopsin kinase activity, transferase activity; CC: cell cortex, cytoplasm, cytosol, dendrite, neuronal cell body, plasma membrane
Pathways: Chemokine signaling pathway - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Inactivation, recovery and regulation of the phototransduction cascade, Morphine addiction - Mus musculus (mouse), Sensory Perception, The phototransduction cascade, Visual phototransduction
UniProt: O70291
Entrez ID: 14772
|
Does Knockout of Cltc in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Cltc
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cltc (clathrin heavy chain)
Type: protein-coding
Summary: Enables protein kinase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; endocytosis; and negative regulation of hyaluronan biosynthetic process. Predicted to act upstream of or within mitotic spindle assembly. Located in clathrin-coated pit. Part of membrane coat. Is active in several cellular components, including photoreceptor ribbon synapse; postsynaptic endocytic zone; and presynaptic endocytic zone membrane. Is expressed in several structures, including brain; early embryo; placenta; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi organization, amyloid-beta clearance by transcytosis, autophagy, cell division, clathrin coat assembly, clathrin coat disassembly, clathrin-dependent endocytosis, intracellular protein transport, mitotic cell cycle, mitotic spindle assembly, negative regulation of hyaluronan biosynthetic process, negative regulation of protein localization to plasma membrane, receptor internalization, receptor-mediated endocytosis, regulation of mitotic spindle organization, retrograde transport, endosome to Golgi, synaptic vesicle endocytosis, transferrin transport, vesicle-mediated transport; MF: ankyrin binding, clathrin light chain binding, disordered domain specific binding, double-stranded RNA binding, heat shock protein binding, low-density lipoprotein particle receptor binding, peptide binding, protein binding, protein kinase binding, protein serine/threonine kinase binding, structural molecule activity, ubiquitin-specific protease binding; CC: Myb complex, T-tubule, centriolar satellite, clathrin coat, clathrin coat of coated pit, clathrin coat of trans-Golgi network vesicle, clathrin complex, clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, cytosol, endomembrane system, endosome, extrinsic component of synaptic vesicle membrane, glutamatergic synapse, lysosome, melanosome, membrane, membrane coat, mitochondrion, mitotic spindle, mitotic spindle microtubule, myelin sheath, photoreceptor ribbon synapse, postsynaptic endocytic zone, presynaptic endocytic zone membrane, protein-containing complex, sarcolemma, spindle
Pathways: Adaptive Immune System, Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Beta-catenin independent WNT signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Golgi Associated Vesicle Biogenesis, Huntington disease - Mus musculus (mouse), Immune System, L1CAM interactions, LDL clearance, Lysosome - Mus musculus (mouse), Lysosome Vesicle Biogenesis, MHC class II antigen presentation, Membrane Trafficking, Nervous system development, PCP/CE pathway, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, RHO GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, Recycling pathway of L1, Retrograde neurotrophin signalling, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Synaptic vesicle cycle - Mus musculus (mouse), Transport of small molecules, VLDLR internalisation and degradation, Vesicle-mediated transport, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, WNT5A-dependent internalization of FZD4, trans-Golgi Network Vesicle Budding
UniProt: Q68FD5
Entrez ID: 67300
|
Does Knockout of Aqp11 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Aqp11
|
cell proliferation
|
Regulatory T cell
|
Gene: Aqp11 (aquaporin 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosomal lumen acidification, glycerol transmembrane transport, hydrogen peroxide transmembrane transport, intracellular oxygen homeostasis, intracellular water homeostasis, kidney development, negative regulation of ERAD pathway, negative regulation of epithelial cell proliferation, negative regulation of response to endoplasmic reticulum stress, positive regulation of cell population proliferation, protein glycosylation, protein homooligomerization, protein targeting to membrane, proximal tubule development, transmembrane transport, water transport; MF: channel activity, glycerol channel activity, hydrogen peroxide channel activity, identical protein binding, water channel activity; CC: cell surface, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Aquaporin-mediated transport, Passive transport by Aquaporins, Transport of small molecules
UniProt: Q8BHH1
Entrez ID: 66333
|
Does Knockout of Nans in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Nans
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nans (N-acetylneuraminic acid synthase (sialic acid synthase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP-N-acetylneuraminate biosynthetic process, N-acetylneuraminate biosynthetic process, N-acetylneuraminate metabolic process, carbohydrate biosynthetic process, glycosylation; MF: N-acylneuraminate-9-phosphate synthase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, Post-translational protein modification, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis
UniProt: Q99J77
Entrez ID: 94181
|
Does Knockout of Cbx2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Cbx2
|
response to virus
|
Microglial Cell Line
|
Gene: Cbx2 (chromobox 2)
Type: protein-coding
Summary: This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in results in male-to-female gonadal sex reversal. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: chromatin organization, development of primary sexual characteristics, negative regulation of transcription by RNA polymerase II; MF: DNA binding, chromatin binding, histone H3K9me2/3 reader activity, protein binding; CC: PRC1 complex, PcG protein complex, chromosome, euchromatin, heterochromatin, nuclear speck, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of RNA binding proteins, SUMOylation of chromatin organization proteins, SUMOylation of transcription cofactors, Transcriptional regulation by RUNX1
UniProt: P30658
Entrez ID: 12416
|
Does Knockout of Tmem63c in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Tmem63c
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tmem63c (transmembrane protein 63c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glomerular filtration, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport; MF: calcium-activated cation channel activity, osmolarity-sensing monoatomic cation channel activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, lysosomal membrane, membrane, plasma membrane
Pathways:
UniProt: Q8CBX0
Entrez ID: 217733
|
Does Knockout of Cox6a2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Cox6a2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Cox6a2 (cytochrome c oxidase subunit 6A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; MF: enzyme regulator activity, oxidoreductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, aerobic respiration -- electron donor II
UniProt: P43023
Entrez ID: 12862
|
Does Knockout of Cnep1r1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Cnep1r1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cnep1r1 (CTD nuclear envelope phosphatase 1 regulatory subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, positive regulation of triglyceride biosynthetic process, protein localization to nucleus; MF: molecular_function, protein phosphatase regulator activity; CC: Nem1-Spo7 phosphatase complex, cytoplasm, cytosol, membrane, nuclear membrane, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Depolymerization of the Nuclear Lamina, M Phase, Mitotic Prophase, Nuclear Envelope Breakdown
UniProt: Q3UJ81
Entrez ID: 382030
|
Does Knockout of Etfdh in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Etfdh
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Etfdh (electron transferring flavoprotein, dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: electron transport chain, fatty acid beta-oxidation using acyl-CoA dehydrogenase, respiratory electron transport chain, response to oxidative stress; MF: 4 iron, 4 sulfur cluster binding, electron transfer activity, electron-transferring-flavoprotein dehydrogenase activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, quinone binding, ubiquinone binding; CC: cytosol, membrane, mitochondrial electron transfer flavoprotein complex, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Respiratory electron transport
UniProt: Q921G7
Entrez ID: 66841
|
Does Knockout of Cul5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Cul5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cul5 (cullin 5)
Type: protein-coding
Summary: Enables ubiquitin ligase complex scaffold activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of neuron migration. Acts upstream of with a negative effect on reelin-mediated signaling pathway. Acts upstream of or within cerebral cortex radially oriented cell migration; protein ubiquitination; and radial glia guided migration of Purkinje cell. Part of Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including brain; eye; genitourinary system; gut; and limb bud. Orthologous to human CUL5 (cullin 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cGAS/STING signaling pathway, cell migration, cerebral cortex radially oriented cell migration, defense response to virus, endoplasmic reticulum unfolded protein response, epithelial to mesenchymal transition, erythropoietin-mediated signaling pathway, growth hormone receptor signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, innate immune response, negative regulation of cGAS/STING signaling pathway, negative regulation of epithelial to mesenchymal transition, negative regulation of focal adhesion assembly, negative regulation of focal adhesion disassembly, negative regulation of growth hormone receptor signaling pathway, positive regulation of focal adhesion assembly, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein catabolic process, protein ubiquitination, radial glia guided migration of Purkinje cell, reelin-mediated signaling pathway, regulation of cytosolic calcium ion concentration, regulation of neuron migration, signal transduction, ubiquitin-dependent protein catabolic process; MF: protein binding, protein-macromolecule adaptor activity, ubiquitin ligase complex scaffold activity, ubiquitin protein ligase binding; CC: Cul5-RING ubiquitin ligase complex, SCF ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, cytosol, nucleus, site of DNA damage
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Downregulation of ERBB2 signaling, Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of CSF3 (G-CSF) signaling, Metabolism of proteins, Neddylation, Post-translational protein modification, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by ERBB2, Signaling by Receptor Tyrosine Kinases, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9D5V5
Entrez ID: 75717
|
Does Knockout of Adam20 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Adam20
|
cell cycle progression
|
breast epithelium
|
Gene: Adam20 (a disintegrin and metallopeptidase domain 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: male gonad development, proteolysis; MF: metal ion binding, metalloendopeptidase activity, metallopeptidase activity, molecular_function; CC: external side of plasma membrane, membrane, plasma membrane, sperm head plasma membrane
Pathways:
UniProt: Q7M763
Entrez ID: 384806
|
Does Knockout of Hspd1 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,549
|
Knockout
|
Hspd1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Hspd1 (heat shock protein 1 (chaperonin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell proliferation, MyD88-dependent toll-like receptor signaling pathway, T cell activation, adhesion of symbiont to host, apoptotic mitochondrial changes, biological process involved in interaction with symbiont, cellular response to interleukin-7, isotype switching to IgG isotypes, mitochondrial unfolded protein response, negative regulation of apoptotic process, negative regulation of execution phase of apoptosis, positive regulation of T cell activation, positive regulation of T cell mediated immune response to tumor cell, positive regulation of cytokine production, positive regulation of execution phase of apoptosis, positive regulation of interferon-alpha production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of macrophage activation, positive regulation of type II interferon production, protein folding, protein import into mitochondrial intermembrane space, protein refolding, protein stabilization, response to cold, response to unfolded protein; MF: ATP binding, ATP-dependent protein folding chaperone, apolipoprotein A-I binding, apolipoprotein binding, cysteine-type endopeptidase activator activity, double-stranded RNA binding, enzyme binding, high-density lipoprotein particle binding, isomerase activity, lipopolysaccharide binding, modification-dependent protein binding, nucleotide binding, p53 binding, protein-containing complex binding, protein-folding chaperone binding, ubiquitin protein ligase binding; CC: Golgi cisterna, cell surface, clathrin-coated pit, coated vesicle, cytoplasm, cytosol, early endosome, extracellular exosome, extracellular space, lipopolysaccharide receptor complex, membrane, migrasome, mitochondrial crista, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, myelin sheath, peroxisomal matrix, plasma membrane, protein-containing complex, secretory granule, sperm midpiece, sperm plasma membrane, zymogen granule
Pathways: Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial protein import, Protein localization, RNA degradation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse)
UniProt: P63038
Entrez ID: 15510
|
Does Knockout of G6pdx in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
G6pdx
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: G6pdx (glucose-6-phosphate dehydrogenase X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NADP+ biosynthetic process, NADP+ metabolic process, NADPH regeneration, angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure, angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure, cellular response to oxidative stress, cholesterol biosynthetic process, erythrocyte development, erythrocyte maturation, glucose 6-phosphate metabolic process, glucose metabolic process, glutathione metabolic process, negative regulation of cell growth involved in cardiac muscle cell development, negative regulation of reactive oxygen species metabolic process, pentose biosynthetic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch, positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, regulation of multicellular organism growth, regulation of neuron apoptotic process, response to ethanol, response to oxidative stress, ribose phosphate biosynthetic process; MF: D-glucose binding, NADP binding, carbohydrate binding, glucose-6-phosphate dehydrogenase activity, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors, protein homodimerization activity; CC: centriolar satellite, cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glutathione metabolism - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), RNA Polymerase II Transcription, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, formaldehyde oxidation I, pentose phosphate pathway, pentose phosphate pathway (oxidative branch)
UniProt: Q00612
Entrez ID: 14381
|
Does Knockout of Mbtps2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Mbtps2
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Mbtps2 (membrane-bound transcription factor peptidase, site 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, bone maturation, cholesterol metabolic process, lipid metabolic process, membrane protein intracellular domain proteolysis, mitotic G2 DNA damage checkpoint signaling, positive regulation of cholesterol biosynthetic process, positive regulation of transcription by RNA polymerase II, protein maturation, proteolysis, regulation of response to endoplasmic reticulum stress, response to endoplasmic reticulum stress, steroid metabolic process; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, transcription regulator activator activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum membrane, membrane
Pathways: ATF6 (ATF6-alpha) activates chaperones, ATF6B (ATF6-beta) activates chaperones, CREB3 factors activate genes, Cellular responses to stimuli, Cellular responses to stress, Metabolism, Metabolism of lipids, Metabolism of steroids, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of cholesterol biosynthesis by SREBP (SREBF), Unfolded Protein Response (UPR)
UniProt: Q8CHX6
Entrez ID: 270669
|
Does Knockout of Caap1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Caap1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Caap1 (caspase activity and apoptosis inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, regulation of apoptotic process
Pathways:
UniProt: Q8VDY9
Entrez ID: 67770
|
Does Knockout of Siah2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Siah2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Siah2 (siah E3 ubiquitin protein ligase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, canonical Wnt signaling pathway, negative regulation of apoptotic process, negative regulation of canonical Wnt signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein catabolic process, protein ubiquitination, regulation of circadian rhythm, regulation of protein ubiquitination, rhythmic process, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, early endosome, neuronal cell body, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Deubiquitination, Immune System, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q06986
Entrez ID: 20439
|
Does Knockout of Txn1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Txn1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Txn1 (thioredoxin 1)
Type: protein-coding
Summary: Enables protein-disulfide reductase activity. Acts upstream of or within cell redox homeostasis; negative regulation of protein export from nucleus; and negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in several structures, including central nervous system; skeleton; and submandibular gland primordium. Orthologous to human TXN (thioredoxin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell redox homeostasis, cellular detoxification of hydrogen peroxide, cellular homeostasis, negative regulation of protein export from nucleus, negative regulation of transcription by RNA polymerase II, positive regulation of DNA binding, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, response to nitric oxide, response to radiation; MF: enzyme binding, protein binding, protein homodimerization activity, protein-disulfide reductase [NAD(P)H] activity, protein-disulfide reductase activity; CC: axon, cytoplasm, cytosol, dendrite, extracellular region, mitochondrion, neuronal cell body, nucleoplasm, nucleus
Pathways: Cellular Senescence, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Immune System, Inflammasomes, Innate Immune System, Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Metabolism of proteins, NOD-like receptor signaling pathway - Mus musculus (mouse), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oxidative Stress Induced Senescence, Parkinson disease - Mus musculus (mouse), Protein repair, RNA Polymerase II Transcription, Salmonella infection - Mus musculus (mouse), TP53 Regulates Metabolic Genes, The NLRP3 inflammasome, Transcriptional Regulation by TP53
UniProt: P10639
Entrez ID: 22166
|
Does Knockout of Stxbp3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Stxbp3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Stxbp3 (syntaxin binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cellular response to type II interferon, exocytosis, insulin secretion, intracellular glucose homeostasis, intracellular protein transport, negative regulation of D-glucose import, negative regulation of calcium ion-dependent exocytosis, negative regulation of transport, neutrophil degranulation, platelet aggregation, presynaptic dense core vesicle exocytosis, protein to membrane docking, protein transport, regulation of biological quality, response to insulin, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: protein binding, protein-containing complex binding, syntaxin binding, syntaxin-1 binding; CC: apical plasma membrane, basolateral plasma membrane, cytoplasm, cytosol, membrane, phagocytic vesicle, plasma membrane, platelet alpha granule, presynapse, secretory granule, specific granule, tertiary granule
Pathways:
UniProt: Q60770
Entrez ID: 20912
|
Does Knockout of Tuba1a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Tuba1a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tuba1a (tubulin, alpha 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult behavior, adult locomotory behavior, cellular response to calcium ion, centrosome cycle, cerebellar cortex morphogenesis, cerebral cortex development, dentate gyrus development, flagellated sperm motility, forebrain morphogenesis, gene expression, glial cell differentiation, hippocampus development, homeostasis of number of cells within a tissue, intracellular protein transport, locomotory behavior, locomotory exploration behavior, memory, microtubule cytoskeleton organization, microtubule polymerization, microtubule-based process, mitotic cell cycle, motor behavior, neurogenesis, neuron apoptotic process, neuron differentiation, neuron migration, neuron projection arborization, organelle transport along microtubule, pyramidal neuron differentiation, regulation of synapse organization, response to L-glutamate, response to mechanical stimulus, response to tumor necrosis factor, smoothened signaling pathway, startle response, synapse organization, visual learning; MF: GTP binding, hydrolase activity, identical protein binding, metal ion binding, nucleotide binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein-containing complex binding, structural constituent of cytoskeleton; CC: axonemal microtubule, cell projection, cilium, condensed chromosome, cytoplasm, cytoplasmic microtubule, cytoplasmic ribonucleoprotein granule, cytoskeleton, cytosol, membrane raft, microtubule, microtubule cytoskeleton, motile cilium, myelin sheath, neuromuscular junction, plasma membrane, recycling endosome, sperm flagellum, synapse
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Aggrephagy, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Antiviral mechanism by IFN-stimulated genes, Apoptosis - Mus musculus (mouse), Asparagine N-linked glycosylation, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, Cytokine Signaling in Immune system, Developmental Biology, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, G2/M Transition, Gap junction - Mus musculus (mouse), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hedgehog 'off' state, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, L1CAM interactions, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Recycling pathway of L1, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Salmonella infection - Mus musculus (mouse), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Mus musculus (mouse), Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P68369
Entrez ID: 22142
|
Does Knockout of Ccr4 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Ccr4
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Ccr4 (C-C motif chemokine receptor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium-mediated signaling, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, homeostasis of number of cells, immune response, inflammatory response, interneuron migration, neuron migration, positive regulation of cytosolic calcium ion concentration, positive regulation of positive chemotaxis, signal transduction, tolerance induction; MF: C-C chemokine binding, C-C chemokine receptor activity, G protein-coupled receptor activity, chemokine receptor activity; CC: external side of plasma membrane, membrane, neuronal cell body, plasma membrane
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral carcinogenesis - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P51680
Entrez ID: 12773
|
Does Knockout of Tmem51 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Tmem51
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tmem51 (transmembrane protein 51)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q99LG1
Entrez ID: 214359
|
Does Knockout of Ppp1r3a in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Ppp1r3a
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Ppp1r3a (protein phosphatase 1, regulatory subunit 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycogen metabolic process, regulation of glycogen biosynthetic process; MF: glycogen binding, protein phosphatase 1 binding, protein serine/threonine phosphatase activity; CC: membrane, protein phosphatase type 1 complex
Pathways: Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse)
UniProt: Q99MR9
Entrez ID: 140491
|
Does Knockout of Gpn1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Gpn1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gpn1 (GPN-loop GTPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q8VCE2
Entrez ID: 74254
|
Does Knockout of Csdc2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Csdc2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Csdc2 (cold shock domain containing C2, RNA binding)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA processing, regulation of mRNA stability; MF: RNA binding, mRNA 3'-UTR binding, nucleic acid binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q91YQ3
Entrez ID: 105859
|
Does Knockout of Mfsd2a in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Mfsd2a
|
cell cycle progression
|
breast epithelium
|
Gene: Mfsd2a (MFSD2 lysolipid transporter A, lysophospholipid)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, carbohydrate transport, cellular response to starvation, cognition, embryonic brain development, energy homeostasis, establishment of blood-brain barrier, establishment of blood-retinal barrier, fatty acid transport, hippocampus development, lipid translocation, lipid transport, lipid transport across blood-brain barrier, long-chain fatty acid transport, lysophospholipid translocation, lysophospholipid transport, maintenance of blood-brain barrier, motor behavior, negative regulation of fatty acid beta-oxidation, photoreceptor cell morphogenesis, photoreceptor cell outer segment organization, positive regulation of cell growth, positive regulation of triglyceride biosynthetic process, regulation of dendrite development, regulation of multicellular organism growth, regulation of neuron projection arborization, regulation of phosphatidylcholine metabolic process, regulation of phosphatidylethanolamine metabolic process, regulation of phosphatidylserine metabolic process, retina morphogenesis in camera-type eye, retinal pigment epithelium development, transcytosis, transmembrane transport, very-low-density lipoprotein particle assembly; MF: fatty acid transmembrane transporter activity, long-chain fatty acid transmembrane transporter activity, lysophosphatidylcholine flippase activity, lysophospholipid:sodium symporter activity, oleate transmembrane transporter activity, symporter activity; CC: cytoplasmic ribonucleoprotein granule, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PC
UniProt: Q9DA75
Entrez ID: 76574
|
Does Knockout of Adam7 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Adam7
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Adam7 (a disintegrin and metallopeptidase domain 7)
Type: protein-coding
Summary: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is specifically expressed in epididymis where the encoded protein is transferred to the sperm surface during epididymal transit. This gene is located adjacent to a related gene from the ADAM family of proteins on chromosome 14. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: epididymis development, epithelial cell morphogenesis, positive regulation of flagellated sperm motility, positive regulation of sperm capacitation, proteolysis; MF: endopeptidase activity, metalloendopeptidase activity, metallopeptidase activity, protein binding; CC: apical part of cell, cell surface, membrane, plasma membrane
Pathways:
UniProt: O35227
Entrez ID: 11500
|
Does Knockout of Skint6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Skint6
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Skint6 (selection and upkeep of intraepithelial T cells 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, T cell receptor signaling pathway, regulation of T cell activation, regulation of cytokine production, regulation of leukocyte cell-cell adhesion; CC: external side of plasma membrane, membrane
Pathways:
UniProt: A7XUZ6
Entrez ID: 230622
|
Does Knockout of Rps26 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Rps26
|
response to virus
|
Microglial Cell Line
|
Gene: Rps26 (ribosomal protein S26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, negative regulation of RNA splicing, translation, translation at postsynapse, translation at presynapse; MF: mRNA binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, postsynapse, presynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62855
Entrez ID: 27370
|
Does Knockout of Spaca4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Spaca4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Spaca4 (sperm acrosome associated 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, cell adhesion, fertilization, single fertilization, sperm-egg recognition; CC: acrosomal vesicle, cytoplasmic vesicle, inner acrosomal membrane, membrane, outer acrosomal membrane, plasma membrane, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q80ZQ0
Entrez ID: 69363
|
Does Knockout of Uchl1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Uchl1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Uchl1 (ubiquitin carboxy-terminal hydrolase L1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult walking behavior, axon target recognition, axonal transport of mitochondrion, axonogenesis, cellular response to xenobiotic stimulus, eating behavior, male germ cell proliferation, muscle cell development, negative regulation of MAPK cascade, neuromuscular process, positive regulation of glycolytic process, protein catabolic process, protein deubiquitination, proteolysis, response to ischemia, ubiquitin-dependent protein catabolic process; MF: alpha-2A adrenergic receptor binding, cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, omega peptidase activity, peptidase activity, ribosome binding, signaling receptor inhibitor activity, ubiquitin binding, ubiquitin protein ligase binding; CC: axon, axon cytoplasm, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, myelin sheath, neuron projection terminus, neuronal cell body, nucleoplasm, plasma membrane
Pathways: Deubiquitination, Metabolism of proteins, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, UCH proteinases
UniProt: Q9R0P9
Entrez ID: 22223
|
Does Knockout of Ska3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Ska3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ska3 (spindle and kinetochore associated complex subunit 3)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity. Involved in establishment of meiotic spindle orientation and spindle assembly involved in female meiosis. Located in meiotic spindle. Is expressed in several structures, including brain; heart ventricle; lung; and vertebral axis musculature. Orthologous to human SKA3 (spindle and kinetochore associated complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, cell division, chromosome segregation, establishment of meiotic spindle orientation, metaphase chromosome alignment, mitotic cell cycle, mitotic metaphase chromosome alignment, mitotic sister chromatid segregation, negative regulation of mitotic spindle assembly checkpoint signaling, regulation of microtubule polymerization or depolymerization, spindle assembly involved in female meiosis; MF: microtubule binding, molecular_function; CC: SKA complex, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, meiotic spindle, microtubule, mitotic spindle, outer kinetochore, spindle, spindle microtubule
Pathways:
UniProt: Q8C263
Entrez ID: 219114
|
Does Knockout of Exog in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Exog
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Exog (exo/endonuclease G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: 5'-3' exonuclease activity, RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, single-stranded DNA endodeoxyribonuclease activity; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleus, protein-containing complex
Pathways:
UniProt: Q8C163
Entrez ID: 208194
|
Does Knockout of Naaladl1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Naaladl1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Naaladl1 (N-acetylated alpha-linked acidic dipeptidase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: peptide catabolic process, proteolysis; MF: aminopeptidase activity, calcium ion binding, carboxypeptidase activity, hydrolase activity, metal ion binding, metallopeptidase activity, peptidase activity, protein homodimerization activity, zinc ion binding; CC: apical plasma membrane, cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q7M758
Entrez ID: 381204
|
Does Knockout of Ipmk in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ipmk
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ipmk (inositol polyphosphate multikinase)
Type: protein-coding
Summary: Enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Acts upstream of or within inositol phosphate biosynthetic process and neural tube formation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; hindlimb ridge; nervous system; retina nuclear layer; and trunk somite. Orthologous to human IPMK (inositol polyphosphate multikinase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: inositol phosphate biosynthetic process, inositol trisphosphate metabolic process, lipid metabolic process, necroptotic process, neural tube formation, phosphatidylinositol metabolic process; MF: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, ATP binding, flavonoid binding, inositol tetrakisphosphate kinase activity, inositol-1,3,4,5-tetrakisphosphate 6-kinase activity, inositol-1,3,4,6-tetrakisphosphate 5-kinase activity, inositol-1,4,5,6-tetrakisphosphate 3-kinase activity, inositol-1,4,5-trisphosphate 3-kinase activity, inositol-1,4,5-trisphosphate 6-kinase activity, kinase activity, metal ion binding, nucleotide binding, transferase activity; CC: ciliary basal body, cytoplasm, nucleoplasm, nucleus
Pathways: Inositol phosphate metabolism - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse)
UniProt: Q7TT16
Entrez ID: 69718
|
Does Knockout of Myl12a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Myl12a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Myl12a (myosin, light chain 12A, regulatory, non-sarcomeric)
Type: protein-coding
Summary: Enables glutamate receptor binding activity. Acts upstream of or within protein localization to plasma membrane and regulation of cell shape. Located in Z disc and stress fiber. Part of myosin II complex. Orthologous to human MYL12A (myosin light chain 12A). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology:
Pathways: Axon guidance - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: D3YV37, Q6ZWQ9, D3Z249
Entrez ID: 67268
|
Does Knockout of Pkn1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Pkn1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pkn1 (protein kinase N1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell apoptotic process, B cell homeostasis, chromatin organization, chromatin remodeling, epithelial cell migration, hyperosmotic response, intracellular signal transduction, negative regulation of B cell proliferation, positive regulation of DNA-templated transcription, post-translational protein modification, regulation of cell motility, regulation of germinal center formation, regulation of immunoglobulin production, regulation of transcription by RNA polymerase II, renal system process, signal transduction, spleen development; MF: ATP binding, chromatin binding, diacylglycerol-dependent serine/threonine kinase activity, histone H3T11 kinase activity, histone binding, histone deacetylase binding, kinase activity, nuclear androgen receptor binding, nucleotide binding, protein binding, protein kinase C binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, small GTPase binding, transcription coactivator activity, transferase activity; CC: cleavage furrow, cytoplasm, cytoplasmic vesicle, endosome, membrane, midbody, nucleus, plasma membrane, protein-containing complex
Pathways: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, NOD-like receptor signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), RAC1 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate PKNs, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Yersinia infection - Mus musculus (mouse)
UniProt: P70268
Entrez ID: 320795
|
Does Knockout of Oip5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Oip5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Oip5 (Opa interacting protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CENP-A containing chromatin assembly, cell division, chromosome segregation, pericentric heterochromatin organization; MF: identical protein binding, metal ion binding; CC: CENP-A recruiting complex, Cajal body, chromatin, chromocenter, chromosome, chromosome, centromeric region, nuclear speck, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, Nucleosome assembly
UniProt: A2AQ14
Entrez ID: 70645
|
Does Knockout of Ints11 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Ints11
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ints11 (integrator complex subunit 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, snRNA 3'-end processing, snRNA processing, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: RNA endonuclease activity, hydrolase activity, metal ion binding; CC: INTAC complex, cytoplasm, cytosol, integrator complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q9CWS4
Entrez ID: 71957
|
Does Knockout of Trmt112 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Trmt112
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Trmt112 (tRNA methyltransferase 11-2)
Type: protein-coding
Summary: Predicted to enable protein heterodimerization activity; protein methyltransferase activity; and tRNA methyltransferase activator activity. Involved in peptidyl-glutamine methylation. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be part of tRNA (m2G10) methyltransferase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; gut; limb bud; lung; and sensory organ. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: maturation of LSU-rRNA, maturation of SSU-rRNA, peptidyl-glutamine methylation, positive regulation of rRNA processing, rRNA (guanine-N7)-methylation, rRNA methylation, tRNA methylation, transcription initiation-coupled chromatin remodeling; MF: protein binding, protein heterodimerization activity, protein methyltransferase activity, tRNA methyltransferase activator activity; CC: cytoplasm, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex, tRNA (m2G10) methyltransferase complex
Pathways: Biological oxidations, Eukaryotic Translation Termination, Metabolism, Metabolism of proteins, Methylation, Phase II - Conjugation of compounds, Translation
UniProt: Q9DCG9
Entrez ID: 67674
|
Does Knockout of Zranb1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Zranb1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zranb1 (zinc finger, RAN-binding domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, autophagosome assembly, cell migration, cytoskeleton organization, phosphatidylinositol phosphate biosynthetic process, positive regulation of Wnt signaling pathway, protein K29-linked deubiquitination, protein K33-linked deubiquitination, protein K63-linked deubiquitination, protein deubiquitination, protein deubiquitination involved in ubiquitin-dependent protein catabolic process, proteolysis, regulation of cell morphogenesis; MF: K63-linked polyubiquitin modification-dependent protein binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, metal ion binding, peptidase activity, polyubiquitin modification-dependent protein binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Degradation of beta-catenin by the destruction complex, Deubiquitination, Metabolism of proteins, Ovarian tumor domain proteases, Post-translational protein modification, Signal Transduction, Signaling by WNT
UniProt: Q7M760
Entrez ID: 360216
|
Does Knockout of Sdf2 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Sdf2
|
cell proliferation
|
Regulatory T cell
|
Gene: Sdf2 (stromal cell derived factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein refolding; MF: misfolded protein binding; CC: endoplasmic reticulum, extracellular region, protein folding chaperone complex, protein-containing complex
Pathways:
UniProt: Q9DCT5
Entrez ID: 20316
|
Does Knockout of Ppp1r35 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Ppp1r35
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ppp1r35 (protein phosphatase 1, regulatory subunit 35)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: notochord morphogenesis, positive regulation of centriole elongation, positive regulation of cilium assembly; MF: phosphatase binding, protein phosphatase inhibitor activity; CC: centriole, centrosome, cytoplasm, cytoskeleton
Pathways:
UniProt: Q9D8C8
Entrez ID: 69871
|
Does Knockout of Dtl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Dtl
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dtl (denticleless E3 ubiquitin protein ligase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA replication, mitotic G2 DNA damage checkpoint signaling, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of catabolic process, positive regulation of protein catabolic process, positive regulation of protein metabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of cell cycle, response to UV, rhythmic process, translesion synthesis, ubiquitin-dependent protein catabolic process; MF: protein-macromolecule adaptor activity, ubiquitin-protein transferase activity; CC: Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, centrosome, chromosome, cytoplasm, cytoskeleton, cytosol, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Repair, Metabolism of proteins, Neddylation, Post-translational protein modification, Recognition of DNA damage by PCNA-containing replication complex
UniProt: Q3TLR7
Entrez ID: 76843
|
Does Knockout of Myg1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Myg1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Myg1 (melanocyte proliferating gene 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: locomotory exploration behavior, mRNA processing, mitochondrial RNA metabolic process, rRNA processing; MF: 3'-5'-RNA exonuclease activity, hydrolase activity, molecular_function, nuclease activity; CC: cytoplasm, mitochondrial matrix, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9JK81
Entrez ID: 60315
|
Does Knockout of Rpl35a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Rpl35a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rpl35a (ribosomal protein L35A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, rRNA processing, ribosomal large subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: ribonucleoprotein complex binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, mitochondrion, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O55142
Entrez ID: 57808
|
Does Knockout of Tm4sf1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Tm4sf1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tm4sf1 (transmembrane 4 superfamily member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q64302
Entrez ID: 17112
|
Does Activation of Dnajc19 in Mouse cell causally result in protein/peptide accumulation?
| 1
| 690
|
Activation
|
Dnajc19
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Dnajc19 (DnaJ heat shock protein family (Hsp40) member C19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: genitalia development, protein import into mitochondrial matrix, protein transport, regulation of cardiolipin metabolic process, visual perception; MF: ATPase activator activity, protein binding; CC: PAM complex, Tim23 associated import motor, inner mitochondrial membrane protein complex, matrix side of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CQV7
Entrez ID: 67713
|
Does Knockout of Kdm1a in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,157
|
Knockout
|
Kdm1a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Kdm1a (lysine (K)-specific demethylase 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair-dependent chromatin remodeling, cell differentiation, cellular response to UV, cellular response to gamma radiation, chromatin organization, epigenetic regulation of gene expression, epithelial to mesenchymal transition, granulocyte differentiation, guanine metabolic process, muscle cell development, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of neurogenesis, negative regulation of transcription by RNA polymerase II, negative regulation of transcription initiation-coupled chromatin remodeling, neuron projection extension, neuron projection morphogenesis, pituitary gland development, positive regulation of cell differentiation, positive regulation of cold-induced thermogenesis, positive regulation of epithelial to mesenchymal transition, positive regulation of erythrocyte differentiation, positive regulation of megakaryocyte differentiation, positive regulation of multicellular organismal process, positive regulation of neural precursor cell proliferation, positive regulation of neuroblast proliferation, positive regulation of protein ubiquitination, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of double-strand break repair via homologous recombination, regulation of neurogenesis, regulation of primitive erythrocyte differentiation, regulation of protein localization, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor binding, FAD-dependent H3K4me/H3K4me3 demethylase activity, MRF binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, enzyme binding, flavin adenine dinucleotide binding, histone H3K4 demethylase activity, histone H3K9 demethylase activity, histone H3K9me2/H3K9me3 demethylase activity, histone demethylase activity, identical protein binding, lncRNA binding, nuclear androgen receptor binding, oxidoreductase activity, p53 binding, promoter-specific chromatin binding, protein binding, protein demethylase activity, telomeric repeat-containing RNA binding, transcription coactivator activity, transcription corepressor activity; CC: DNA repair complex, chromatin, chromosome, chromosome, telomeric region, histone methyltransferase complex, nucleoplasm, nucleus, protein-containing complex
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chromatin modifying enzymes, Chromatin organization, ESR-mediated signaling, Estrogen-dependent gene expression, Factors involved in megakaryocyte development and platelet production, HDACs deacetylate histones, HDMs demethylate histones, Hemostasis, Negative Regulation of CDH1 Gene Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Signal Transduction, Signaling by Nuclear Receptors, Thermogenesis - Mus musculus (mouse)
UniProt: Q6ZQ88
Entrez ID: 99982
|
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