prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Dmrtb1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Dmrtb1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Dmrtb1 (DMRT-like family B with proline-rich C-terminal, 1)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and sex differentiation. Predicted to be active in nucleus. Is expressed in brain; ovary; and testis. Orthologous to human DMRTB1 (DMRT like family B with proline rich C-terminal 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, sex differentiation; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding; CC: nucleus
Pathways:
UniProt: A2A9I7
Entrez ID: 56296
|
Does Knockout of Spag4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Spag4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Spag4 (sperm associated antigen 4)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in microtubule. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. Is expressed in brainstem; genitourinary system; submandibular gland; and trachea. Orthologous to human SPAG4 (sperm associated antigen 4). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell differentiation, spermatogenesis; MF: identical protein binding, protein-membrane adaptor activity; CC: cell projection, cilium, cytoplasm, cytoskeleton, meiotic nuclear membrane microtubule tethering complex, membrane, microtubule, motile cilium, nuclear envelope, nuclear inner membrane, nucleus
Pathways:
UniProt: Q9JJF2
Entrez ID: 245865
|
Does Knockout of Agtr2 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Agtr2
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Agtr2 (angiotensin II receptor, type 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger, angiotensin-activated signaling pathway, angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure, blood vessel diameter maintenance, brain renin-angiotensin system, cell growth involved in cardiac muscle cell development, cell surface receptor signaling pathway, cellular response to dexamethasone stimulus, cerebellar cortex development, dopamine biosynthetic process, exploration behavior, inflammatory response, intracellular sodium ion homeostasis, kidney morphogenesis, negative regulation of fibroblast proliferation, negative regulation of heart rate, negative regulation of icosanoid secretion, negative regulation of neurotrophin TRK receptor signaling pathway, negative regulation of norepinephrine secretion, nitric oxide-cGMP-mediated signaling, positive regulation of DNA-templated transcription, positive regulation of branching involved in ureteric bud morphogenesis, positive regulation of cell population proliferation, positive regulation of cytokine production, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of metanephric glomerulus development, regulation of apoptotic process, regulation of blood volume by renin-angiotensin, regulation of metanephros size, regulation of protein import into nucleus, regulation of systemic arterial blood pressure by circulatory renin-angiotensin, renal system process involved in regulation of systemic arterial blood pressure, renin-angiotensin regulation of aldosterone production, signal transduction, vasodilation; MF: G protein-coupled receptor activity, angiotensin type II receptor activity; CC: membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Renin-angiotensin system - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P35374
Entrez ID: 11609
|
Does Knockout of Slx4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Slx4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Slx4 (SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae))
Type: protein-coding
Summary: This gene encodes a protein containing a BTB (POZ) domain that comprises a subunit of structure-specific endonucleases. The encoded protein aids in the resolution of DNA secondary structures that arise during the processes of DNA repair and recombination. Knock out of this gene in mouse recapitulates the phenotype of the human disease Fanconi anemia, including blood cytopenia and susceptibility to genomic instability. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: DNA damage response, DNA double-strand break processing involved in repair via single-strand annealing, DNA recombination, DNA repair, DNA replication, double-strand break repair via homologous recombination, negative regulation of telomere maintenance via telomere lengthening, nucleotide-excision repair, positive regulation of t-circle formation, positive regulation of telomere maintenance, resolution of meiotic recombination intermediates, response to intra-S DNA damage checkpoint signaling, t-circle formation, telomeric D-loop disassembly; MF: DNA binding, enzyme activator activity, metal ion binding, zinc ion binding; CC: ERCC4-ERCC1 complex, Holliday junction resolvase complex, Slx1-Slx4 complex, chromatin, chromosome, telomeric region, nucleoplasm, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q6P1D7
Entrez ID: 52864
|
Does Knockout of Fbxw13 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Fbxw13
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fbxw13 (F-box and WD-40 domain protein 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytoplasm
Pathways:
UniProt: A0A0G2JDF9, Q8BI57, A0A0G2JFH5
Entrez ID: 211305
|
Does Knockout of Clns1a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Clns1a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Clns1a (chloride channel, nucleotide-sensitive, 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cell volume homeostasis, chloride transport, mRNA cis splicing, via spliceosome, mRNA processing, negative regulation of cell volume, positive regulation of mRNA splicing, via spliceosome, spliceosomal snRNP assembly; CC: cilium, cytoplasm, cytoskeleton, cytosol, methylosome, nucleoplasm, nucleus, pICln-Sm protein complex, plasma membrane, spliceosomal complex
Pathways:
UniProt: Q923F1
Entrez ID: 12729
|
Does Knockout of Cand1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Cand1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cand1 (cullin associated and neddylation disassociated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF complex assembly, cell differentiation, negative regulation of catalytic activity, positive regulation of DNA-templated transcription, positive regulation of RNA polymerase II transcription preinitiation complex assembly, protein ubiquitination; MF: TBP-class protein binding, protein binding; CC: Golgi apparatus, cullin-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Immune System, Innate Immune System, Iron uptake and transport, Metabolism of proteins, Neddylation, Neutrophil degranulation, Post-translational protein modification, Transport of small molecules
UniProt: Q6ZQ38
Entrez ID: 71902
|
Does Knockout of Nans in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Nans
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nans (N-acetylneuraminic acid synthase (sialic acid synthase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP-N-acetylneuraminate biosynthetic process, N-acetylneuraminate biosynthetic process, N-acetylneuraminate metabolic process, carbohydrate biosynthetic process, glycosylation; MF: N-acylneuraminate-9-phosphate synthase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, Post-translational protein modification, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis
UniProt: Q99J77
Entrez ID: 94181
|
Does Knockout of Hcfc1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Hcfc1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hcfc1 (host cell factor C1)
Type: protein-coding
Summary: This gene encodes a transcription cofactor that regulates the progression of cell cycle and maintain the ability of embryonic stem cells to self-renew. The encoded protein is a large precursor that undergoes site-specific proteolytic cleavage to yield N- and C-terminal chains that form a non-covalent heterodimer. The encoded protein has been implicated in the regulation of expression of immediate early genes after herpes simplex virus infection and glucose-stimulated secretion of insulin by pancreatic beta cells. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: blastocyst hatching, chromatin organization, chromatin remodeling, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of transcription by RNA polymerase II, protein stabilization, regulation of DNA-templated transcription, regulation of protein-containing complex assembly, release from viral latency; MF: DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, identical protein binding, protein binding, protein-macromolecule adaptor activity, transcription coactivator activity; CC: MLL1 complex, MLL1/2 complex, NSL complex, Set1C/COMPASS complex, axon, cytoplasm, dendrite, extracellular matrix, histone acetyltransferase complex, histone methyltransferase complex, neuronal cell body, nuclear chromosome, nucleoplasm, nucleus, protein-containing complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Deubiquitination, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones, Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of proteins, Post-translational protein modification, UCH proteinases
UniProt: Q61191
Entrez ID: 15161
|
Does Knockout of Cnot7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Cnot7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cnot7 (CCR4-NOT transcription complex, subunit 7)
Type: protein-coding
Summary: Enables piRNA binding activity and poly(A)-specific ribonuclease activity. Involved in positive regulation of mRNA catabolic process and spermatogenesis. Acts upstream of or within P-body assembly and positive regulation of RNA metabolic process. Located in P-body and nucleus. Part of CCR4-NOT complex. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and skeleton. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: P-body assembly, deadenylation-dependent decapping of nuclear-transcribed mRNA, defense response to virus, miRNA-mediated gene silencing by mRNA destabilization, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of type I interferon-mediated signaling pathway, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, nuclear-transcribed mRNA poly(A) tail shortening, piRNA-mediated gene silencing by mRNA destabilization, positive regulation of cell population proliferation, positive regulation of mRNA catabolic process, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of transcription by RNA polymerase II, positive regulation of viral genome replication, regulation of translation, regulatory ncRNA-mediated gene silencing, spermatogenesis; MF: 3'-5'-RNA exonuclease activity, DNA-binding transcription factor binding, RNA binding, RNA exonuclease activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, piRNA binding, poly(A)-specific ribonuclease activity, protein binding, transcription corepressor activity; CC: CCR4-NOT complex, CCR4-NOT core complex, P-body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, nuclear body, nuclear speck, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Polymerase II Transcription, RNA degradation - Mus musculus (mouse), TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: Q60809
Entrez ID: 18983
|
Does Knockout of Tpt1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Tpt1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tpt1 (tumor protein, translationally-controlled 1)
Type: protein-coding
Summary: Enables DNA-binding transcription factor binding activity. Involved in negative regulation of ectoderm development and stem cell population maintenance. Located in nucleoplasm. Is expressed in cerebral cortex ventricular layer; cortical plate; sciatic nerve; and testis. Orthologous to several human genes including TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of ectoderm development, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, response to virus, spermatogenesis, stem cell population maintenance; MF: DNA-binding transcription factor binding, calcium ion binding, protein binding; CC: cytoplasm, cytoplasmic microtubule, cytosol, extracellular space, multivesicular body, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: P63028
Entrez ID: 22070
|
Does Knockout of Smarce1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Smarce1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Smarce1 (SWI/SNF related BAF chromatin remodeling complex subunit E1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, nervous system development, neurogenesis, nucleosome disassembly, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: DNA binding, N-acetyltransferase activity, RNA binding, nuclear receptor binding, protein binding; CC: RSC-type complex, SWI/SNF complex, bBAF complex, brahma complex, chromatin, kinetochore, nBAF complex, npBAF complex, nuclear matrix, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: O54941
Entrez ID: 57376
|
Does Knockout of Dnmbp in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Dnmbp
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dnmbp (dynamin binding protein)
Type: protein-coding
Summary: This gene encodes a member of the DBL family of guanine nucleotide exchange factors. The encoded protein has been proposed to regulate the actin cytoskeleton by specifically activating the Rho-family GTPase Cdc42. An interaction between the encoded protein and a Listeria protein has been shown to mediate Listeria infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cilium assembly, intracellular signal transduction, regulation of cell shape; MF: guanyl-nucleotide exchange factor activity, protein binding; CC: Golgi apparatus, Golgi stack, anchoring junction, cell-cell junction, cytoplasm, cytoskeleton, cytosol, nuclear body, nucleolus, nucleoplasm, presynapse, synapse, synaptic vesicle
Pathways: CDC42 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6TXD4
Entrez ID: 71972
|
Does Knockout of Slc25a51 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Slc25a51
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc25a51 (solute carrier family 25, member 51)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NAD+ biosynthetic process via the salvage pathway, NADP+ biosynthetic process, aerobic electron transport chain, mitochondrial NAD transmembrane transport, nicotinamide riboside metabolic process; MF: NAD transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Nicotinate metabolism
UniProt: Q5HZI9
Entrez ID: 230125
|
Does Knockout of Brap in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,171
|
Knockout
|
Brap
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Brap (BRCA1 associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, Ras protein signal transduction, negative regulation of signal transduction, protein ubiquitination; MF: identical protein binding, metal ion binding, nuclear localization sequence binding, nucleic acid binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nuclear membrane, nucleoplasm, ubiquitin ligase complex
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of MAPK pathway, RAF activation, RAF/MAP kinase cascade, Ras signaling pathway - Mus musculus (mouse), Signal Transduction
UniProt: Q99MP8
Entrez ID: 72399
|
Does Knockout of Wdr59 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Wdr59
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Wdr59 (WD repeat domain 59)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to amino acid starvation, cellular response to nutrient levels, positive regulation of TORC1 signaling, protein localization to plasma membrane; MF: metal ion binding, molecular_function, signaling adaptor activity, zinc ion binding; CC: GATOR2 complex, Seh1-associated complex, cytosol, lysosomal membrane, lysosome, membrane, vacuolar membrane
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q8C0M0
Entrez ID: 319481
|
Does Knockout of Nfyb in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Nfyb
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nfyb (nuclear transcription factor-Y beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to leukemia inhibitory factor, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein heterodimerization activity, protein-containing complex binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: CCAAT-binding factor complex, RNA polymerase II transcription regulator complex, nucleoplasm, nucleus, protein-DNA complex, transcription regulator complex
Pathways: Antigen processing and presentation - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: P63139
Entrez ID: 18045
|
Does Knockout of Pgghg in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Pgghg
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pgghg (protein glucosylgalactosylhydroxylysine glucosidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process; MF: catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, protein-glucosylgalactosylhydroxylysine glucosidase activity; CC: cytosol
Pathways:
UniProt: Q8BP56
Entrez ID: 212974
|
Does Knockout of 4933428G20Rik in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
4933428G20Rik
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: 4933428G20Rik (RIKEN cDNA 4933428G20 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Ric8a in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Ric8a
|
response to virus
|
Microglial Cell Line
|
Gene: Ric8a (RIC8 guanine nucleotide exchange factor A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, basement membrane organization, cell migration involved in gastrulation, cell-cell adhesion involved in gastrulation, gastrulation, in utero embryonic development, protein folding, regulation of G protein-coupled receptor signaling pathway, response to light stimulus, vasculature development, visual learning; MF: G-protein alpha-subunit binding, GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding, protein folding chaperone; CC: cell cortex, cytoplasm, cytosol, membrane, plasma membrane
Pathways: cyclic AMP biosynthesis
UniProt: Q3TIR3
Entrez ID: 101489
|
Does Knockout of Pkmyt1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Pkmyt1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pkmyt1 (protein kinase, membrane associated tyrosine/threonine 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiotic cell cycle, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of G2/MI transition of meiotic cell cycle; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cyclin A/B1/B2 associated events during G2/M transition, G2/M Checkpoints, G2/M DNA replication checkpoint, G2/M Transition, Mitotic G2-G2/M phases, Oocyte meiosis - Mus musculus (mouse), Polo-like kinase mediated events, Progesterone-mediated oocyte maturation - Mus musculus (mouse)
UniProt: Q9ESG9
Entrez ID: 268930
|
Does Knockout of Ckap2l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ckap2l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ckap2l (cytoskeleton associated protein 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, cilium, cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton, mitotic spindle, spindle pole
Pathways:
UniProt: Q7TS74
Entrez ID: 70466
|
Does Knockout of Stard5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Stard5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Stard5 (StAR related lipid transfer domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol import, lipid transport; MF: cholesterol binding, cholesterol transfer activity, lipid binding
Pathways: Bile acid and bile salt metabolism, Metabolism, Metabolism of lipids, Metabolism of steroids, Recycling of bile acids and salts
UniProt: Q9EPQ7
Entrez ID: 170460
|
Does Knockout of Ifna5 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Ifna5
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ifna5 (interferon alpha 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways: Alcoholic liver disease - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Cytosolic DNA-sensing pathway - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q810G2
Entrez ID: 15968
|
Does Knockout of Tmprss11c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Tmprss11c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmprss11c (transmembrane protease, serine 11c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis, self proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cell projection, dendrite, extracellular region, membrane, perikaryon, plasma membrane
Pathways:
UniProt: Q1JRP2
Entrez ID: 435845
|
Does Knockout of Snrpa1 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Snrpa1
|
response to virus
|
Microglial Cell Line
|
Gene: Snrpa1 (small nuclear ribonucleoprotein polypeptide A')
Type: protein-coding
Summary: Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and spermatogenesis. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Is expressed in several structures, including central nervous system; hemolymphoid system; liver; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spermatogenesis; MF: RNA binding, U2 snRNA binding; CC: U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, nuclear body, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P57784
Entrez ID: 68981
|
Does Knockout of Abcb8 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Abcb8
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Abcb8 (ATP-binding cassette, sub-family B member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell volume homeostasis, mitochondrial potassium ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, transmembrane transport; MF: ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, nucleotide binding; CC: membrane, mitochondrial ATP-gated potassium channel complex, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleolus, nucleoplasm
Pathways: ABC transporters - Mus musculus (mouse), ABC-family proteins mediated transport, Mitochondrial ABC transporters, Transport of small molecules
UniProt: Q9CXJ4
Entrez ID: 74610
|
Does Knockout of 4933405O20Rik in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
4933405O20Rik
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: 4933405O20Rik (RIKEN cDNA 4933405O20 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: isocitrate metabolic process, tricarboxylic acid cycle; MF: ATP binding, magnesium ion binding, metal ion binding, nucleotide binding; CC: mitochondrion
Pathways: Citrate cycle (TCA cycle) - Mus musculus (mouse), TCA cycle variation III (eukaryotic)
UniProt: Q8BPC6
Entrez ID: 243996
|
Does Knockout of Ifitm10 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Ifitm10
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ifitm10 (interferon induced transmembrane protein 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q8BR26
Entrez ID: 320802
|
Does Knockout of Agtpbp1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Agtpbp1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Agtpbp1 (ATP/GTP binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: C-terminal protein deglutamylation, adult walking behavior, anterograde axonal transport of mitochondrion, axonal transport, central nervous system neuron development, cerebellar Purkinje cell differentiation, cerebellar Purkinje cell layer development, cerebellum development, eye photoreceptor cell differentiation, mitochondrion organization, negative regulation of cell population proliferation, neuromuscular process, olfactory bulb development, positive regulation of ubiquitin-dependent protein catabolic process, protein side chain deglutamylation, proteolysis, retina development in camera-type eye, retrograde axonal transport of mitochondrion; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, protein binding, tubulin binding, zinc ion binding; CC: axon, axon cytoplasm, centriolar satellite, ciliary basal body, cilium, cytoplasm, cytosol, microtubule cytoskeleton, mitochondrion, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q641K1
Entrez ID: 67269
|
Does Knockout of Riox1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Riox1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Riox1 (ribosomal oxygenase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of DNA repair, negative regulation of DNA-templated transcription, negative regulation of osteoblast differentiation, regulation of DNA repair, ribosome biogenesis; MF: 2-oxoglutarate-dependent dioxygenase activity, dioxygenase activity, histone H3K36 demethylase activity, histone H3K36me/H3K36me2 demethylase activity, histone H3K4 demethylase activity, histone H3K4me/H3K4me2/H3K4me3 demethylase activity, iron ion binding, metal ion binding, oxidoreductase activity, peptidyl-histidine dioxygenase activity, protein binding, protein demethylase activity; CC: nucleolus, nucleoplasm, nucleus
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Protein hydroxylation
UniProt: Q9JJF3
Entrez ID: 71952
|
Does Knockout of Atp6v0e2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Atp6v0e2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Atp6v0e2 (ATPase, H+ transporting, lysosomal V0 subunit E2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification, transmembrane transport; MF: proton-transporting ATPase activity, rotational mechanism; CC: clathrin-coated vesicle membrane, cytoplasmic vesicle, membrane, proton-transporting V-type ATPase, V0 domain, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules
UniProt: Q91XE7
Entrez ID: 76252
|
Does Knockout of Gpt2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Gpt2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Gpt2 (glutamic pyruvate transaminase (alanine aminotransferase) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate metabolic process, L-alanine catabolic process, L-alanine metabolic process, gluconeogenesis; MF: L-alanine:2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: cytoplasm, extracellular space, mitochondrion
Pathways: Alanine metabolism, Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Arginine biosynthesis - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, alanine biosynthesis II, alanine degradation III
UniProt: Q8BGT5
Entrez ID: 108682
|
Does Knockout of Rbm20 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Rbm20
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rbm20 (RNA binding motif protein 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, heart formation, mRNA processing, negative regulation of mRNA splicing, via spliceosome, positive regulation of RNA splicing, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome, regulation of mRNA splicing, via spliceosome, spliceosome-depend formation of circular RNA; MF: RNA binding, mRNA binding, metal ion binding, nucleic acid binding, pre-mRNA intronic binding, splicing factor binding, zinc ion binding; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, nucleus
Pathways:
UniProt: Q3UQS8
Entrez ID: 73713
|
Does Knockout of Nufip1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Nufip1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nufip1 (nuclear FMR1 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: box C/D snoRNP assembly, positive regulation of transcription by RNA polymerase II; MF: ATPase binding, RNA binding, identical protein binding, metal ion binding, protein binding, protein-macromolecule adaptor activity, snoRNA binding, zinc ion binding; CC: fibrillar center, nuclear matrix, nucleolus, nucleoplasm, nucleus, perichromatin fibrils, pre-snoRNP complex, presynaptic active zone, protein-containing complex, synapse, transcription elongation factor complex
Pathways:
UniProt: Q9QXX8
Entrez ID: 27275
|
Does Knockout of Zfp958 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Zfp958
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp958 (zinc finger protein 958)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cytokine production, regulation of gene expression, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: F6R9A8, Q99LG7
Entrez ID: 233987
|
Does Knockout of Tmc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Tmc1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmc1 (transmembrane channel-like gene family 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: auditory receptor cell development, calcium ion transmembrane transport, detection of mechanical stimulus involved in sensory perception of sound, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of calcium ion transmembrane transport, sensory perception of sound, vestibular reflex; MF: calcium channel activity, mechanosensitive monoatomic ion channel activity, protein binding, voltage-gated calcium channel activity; CC: external side of plasma membrane, membrane, plasma membrane, stereocilium, stereocilium tip
Pathways:
UniProt: Q8R4P5
Entrez ID: 13409
|
Does Knockout of Lhfpl3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Lhfpl3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lhfpl3 (lipoma HMGIC fusion partner-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q9CTN8
Entrez ID: 269629
|
Does Knockout of Gm5148 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gm5148
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gm5148 (predicted gene 5148)
Type: protein-coding
Summary: predicted gene 5148
Gene Ontology:
Pathways:
UniProt: Q8BGG2
Entrez ID: 381438
|
Does Knockout of Tsr2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Tsr2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tsr2 (TSR2 20S rRNA accumulation)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing
Pathways:
UniProt: Q8C8T8
Entrez ID: 69499
|
Does Knockout of Cables2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Cables2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cables2 (CDK5 and Abl enzyme substrate 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell division, regulation of cell cycle; CC: cellular_component, cytosol
Pathways:
UniProt: Q8K3M5
Entrez ID: 252966
|
Does Knockout of Ccdc71 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Ccdc71
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccdc71 (coiled-coil domain containing 71)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8VEG0
Entrez ID: 72454
|
Does Knockout of Ptpn5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ptpn5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ptpn5 (protein tyrosine phosphatase, non-receptor type 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exploration behavior, positive regulation of long-term synaptic potentiation, positive regulation of neuron projection development, positive regulation of protein import into nucleus, positive regulation of protein targeting to mitochondrion, positive regulation of receptor internalization, positive regulation of response to drug, regulation of neuron apoptotic process, response to immobilization stress, signal transduction; MF: hydrolase activity, identical protein binding, phosphoprotein phosphatase activity, phosphotyrosine residue binding, protein binding, protein kinase binding, protein tyrosine phosphatase activity; CC: axon, cell junction, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, neuronal cell body, perikaryon, plasma membrane, proximal dendrite, synaptic membrane, synaptic vesicle
Pathways: MAPK signaling pathway - Mus musculus (mouse)
UniProt: P54830
Entrez ID: 19259
|
Does Knockout of Ftsj3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Ftsj3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ftsj3 (FtsJ RNA 2'-O-methyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), methylation, rRNA methylation, rRNA processing, ribosome biogenesis; MF: RNA 2'-O-methyltransferase activity, methyltransferase activity, rRNA (guanine) methyltransferase activity, rRNA (uridine-2'-O-)-methyltransferase activity, rRNA methyltransferase activity, transferase activity; CC: chromosome, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9DBE9
Entrez ID: 56095
|
Does Knockout of Zfp438 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Zfp438
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp438 (zinc finger protein 438)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8BXJ4, Q8BFX2
Entrez ID: 240186
|
Does Knockout of Ogfod2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ogfod2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ogfod2 (2-oxoglutarate and iron-dependent oxygenase domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: L-ascorbic acid binding, dioxygenase activity, iron ion binding, metal ion binding, molecular_function, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Pathways:
UniProt: Q9CQ04
Entrez ID: 66627
|
Does Knockout of Arhgap19 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Arhgap19
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arhgap19 (Rho GTPase activating protein 19)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; male reproductive gland or organ; and trigeminal nerve. Orthologous to human ARHGAP19 (Rho GTPase activating protein 19). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity; CC: cytoplasm, plasma membrane
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BRH3
Entrez ID: 71085
|
Does Knockout of Gspt1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Gspt1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gspt1 (G1 to S phase transition 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translational termination, ribosome disassembly, translation, translational termination; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, translation release factor activity; CC: cytoplasm, cytosol, cytosolic ribosome, translation release factor complex
Pathways: Eukaryotic Translation Termination, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Translation, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q8R050
Entrez ID: 14852
|
Does Knockout of Pou4f3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Pou4f3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pou4f3 (POU domain, class 4, transcription factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, axon extension, cell differentiation, inner ear auditory receptor cell differentiation, inner ear development, inner ear morphogenesis, inner ear receptor cell differentiation, neuromuscular process controlling balance, neuron apoptotic process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, retinal ganglion cell axon guidance, sensory perception of sound, vestibulocochlear nerve development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q63955
Entrez ID: 18998
|
Does Knockout of Rbbp7 in Lung Cancer Cell Line causally result in tumorigenicity?
| 0
| 1,089
|
Knockout
|
Rbbp7
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Rbbp7 (retinoblastoma binding protein 7, chromatin remodeling factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, brain development, cellular heat acclimation, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of cell growth, negative regulation of cell migration, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of DNA-templated transcription, positive regulation of stem cell population maintenance, regulation of DNA-templated transcription, regulation of cell fate specification, regulation of stem cell differentiation, response to steroid hormone; MF: RNA binding, histone binding, protein binding; CC: ATPase complex, ESC/E(Z) complex, NURF complex, NuRD complex, Sin3-type complex, chromosome, telomeric region, cytosol, histone deacetylase complex, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell Cycle, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Chromosome Maintenance, Co-inhibition by PD-1, Deposition of new CENPA-containing nucleosomes at the centromere, Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, HDACs deacetylate histones, Immune System, Intracellular signaling by second messengers, Metabolism of proteins, Neddylation, Negative Regulation of CDH1 Gene Transcription, Nucleosome assembly, Oxidative Stress Induced Senescence, PIP3 activates AKT signaling, PKMTs methylate histone lysines, PRC2 methylates histones and DNA, PTEN Regulation, Post-translational protein modification, RMTs methylate histone arginines, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of PTEN gene transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Signal Transduction, Transcriptional Regulation by E2F6, Transcriptional Regulation by TP53
UniProt: Q60973
Entrez ID: 245688
|
Does Knockout of Ankrd13a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Ankrd13a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ankrd13a (ankyrin repeat domain 13a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of protein localization to endosome, negative regulation of receptor internalization; MF: ubiquitin-modified protein reader activity; CC: cytoplasm, endosome, late endosome, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q80UP5
Entrez ID: 68420
|
Does Knockout of Bpifb3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Bpifb3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Bpifb3 (BPI fold containing family B, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: lipid binding, molecular_function; CC: cytoplasm, extracellular region
Pathways:
UniProt: Q80ZU7
Entrez ID: 378700
|
Does Knockout of Gins3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,287
|
Knockout
|
Gins3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gins3 (GINS complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, cellular senescence, multicellular organism growth; CC: CMG complex, GINS complex, chromosome, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA strand elongation, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: Q9CY94
Entrez ID: 78833
|
Does Knockout of Ubox5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Ubox5
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ubox5 (U box domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein polyubiquitination, protein ubiquitination; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, zinc ion binding; CC: focal adhesion, nuclear body, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q925F4
Entrez ID: 140629
|
Does Knockout of Prss33 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Prss33
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Prss33 (serine protease 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, extracellular region, extracellular space
Pathways:
UniProt: Q80WM7
Entrez ID: 353130
|
Does Knockout of Drap1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Drap1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Drap1 (DR1 associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II general transcription initiation factor binding, TBP-class protein binding, core promoter sequence-specific DNA binding, identical protein binding, protein binding, protein heterodimerization activity, transcription corepressor activity; CC: RNA polymerase II transcription regulator complex, negative cofactor 2 complex, nucleus
Pathways:
UniProt: Q9D6N5
Entrez ID: 66556
|
Does Knockout of Pi4ka in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Pi4ka
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pi4ka (phosphatidylinositol 4-kinase alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell migration, actin cytoskeleton organization, host-mediated perturbation of viral process, lipid metabolic process, myelination in peripheral nervous system, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-mediated signaling, reorganization of cellular membranes to establish viral sites of replication; MF: 1-phosphatidylinositol 4-kinase activity, ATP binding, kinase activity, nucleotide binding, transferase activity; CC: Golgi-associated vesicle membrane, cytoplasm, membrane, plasma membrane
Pathways: 3-phosphoinositide biosynthesis, D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Synthesis of PIPs at the ER membrane, Synthesis of PIPs at the Golgi membrane
UniProt: E9Q3L2
Entrez ID: 224020
|
Does Knockout of Cacna2d4 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Cacna2d4
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Cacna2d4 (calcium channel, voltage-dependent, alpha 2/delta subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, detection of light stimulus involved in visual perception, monoatomic ion transmembrane transport, monoatomic ion transport; MF: calcium channel activity, metal ion binding, voltage-gated calcium channel activity; CC: membrane, monoatomic ion channel complex, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse)
UniProt: Q5RJF7
Entrez ID: 319734
|
Does Knockout of Muc19 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Muc19
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Muc19 (mucin 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, B cell proliferation, T cell differentiation, T cell proliferation, antibacterial innate immune response, cell differentiation involved in salivary gland development, chemokine-mediated signaling pathway, digestive tract development, follicular B cell differentiation, gene expression, hematopoietic progenitor cell differentiation, homeostasis of number of cells, immune response, inflammatory response, innate immune response, lacrimal gland development, lung development, negative regulation of inflammatory response, odontogenesis, response to Gram-positive bacterium, response to virus, salivary gland development, type 2 immune response; MF: hydroxyapatite binding, molecular_function; CC: cellular_component, extracellular region
Pathways: Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, Termination of O-glycan biosynthesis
UniProt: Q6PZE0
Entrez ID: 239611
|
Does Knockout of Lats2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Lats2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lats2 (large tumor suppressor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, hippo signaling, hormone-mediated signaling pathway, inner cell mass cell fate commitment, inner cell mass cellular morphogenesis, intracellular protein localization, intracellular signal transduction, keratinocyte differentiation, negative regulation of canonical Wnt signaling pathway, negative regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of protein localization to nucleus, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of apoptotic process, positive regulation of hippo signaling, protein phosphorylation, regulation of organ growth, regulation of transforming growth factor beta receptor signaling pathway; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centriolar satellite, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton, nucleus, spindle pole
Pathways: Hippo signaling pathway - Mus musculus (mouse), Hippo signaling pathway - multiple species - Mus musculus (mouse), Signal Transduction, Signaling by Hippo
UniProt: Q7TSJ6
Entrez ID: 50523
|
Does Knockout of Chaf1b in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,544
|
Knockout
|
Chaf1b
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Chaf1b (chromatin assembly factor 1, subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin assembly, chromatin organization, nucleosome assembly; CC: CAF-1 complex, chromatin, cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q9D0N7
Entrez ID: 110749
|
Does Knockout of Il23a in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Il23a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Il23a (interleukin 23, alpha subunit p19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, defense response to Gram-negative bacterium, defense response to virus, immune response, immune system process, inflammatory response, innate immune response, negative regulation of interleukin-10 production, positive regulation of NK T cell activation, positive regulation of NK T cell proliferation, positive regulation of T cell mediated cytotoxicity, positive regulation of T cell proliferation, positive regulation of T-helper 1 type immune response, positive regulation of T-helper 17 cell lineage commitment, positive regulation of T-helper 17 type immune response, positive regulation of activated T cell proliferation, positive regulation of alpha-beta T cell activation, positive regulation of defense response to virus by host, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-17 production, positive regulation of leukocyte differentiation, positive regulation of macromolecule biosynthetic process, positive regulation of memory T cell differentiation, positive regulation of natural killer cell proliferation, positive regulation of neutrophil chemotaxis, positive regulation of osteoclast differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, regulation of gene expression, regulation of primary metabolic process, tissue remodeling; MF: cytokine activity, interleukin-23 receptor binding, protein binding; CC: extracellular region, extracellular space, interleukin-23 complex
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-12 family signaling, Interleukin-23 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Signaling by Interleukins, Th17 cell differentiation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q9EQ14
Entrez ID: 83430
|
Does Knockout of Psmb6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Psmb6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Psmb6 (proteasome (prosome, macropain) subunit, beta type 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: endopeptidase activity, hydrolase activity, peptidase activity, threonine-type endopeptidase activity; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q60692
Entrez ID: 19175
|
Does Knockout of Atr in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,540
|
Knockout
|
Atr
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Atr (ataxia telangiectasia and Rad3 related)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, DNA replication, DNA strand resection involved in replication fork processing, G2/M transition of mitotic cell cycle, cellular response to UV, cellular response to gamma radiation, chromatin remodeling, chromosome organization, double-strand break repair, embryo implantation, establishment of RNA localization to telomere, mitotic G2/M transition checkpoint, negative regulation of DNA replication, nuclear envelope organization, nuclear membrane disassembly, nucleobase-containing compound metabolic process, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of biosynthetic process, positive regulation of telomerase catalytic core complex assembly, positive regulation of telomere maintenance via telomerase, protein localization to chromosome, telomeric region, protein localization to site of double-strand break, regulation of double-strand break repair, replication fork processing, replicative senescence, response to mechanical stimulus, telomere maintenance; MF: ATP binding, DNA binding, MutLalpha complex binding, MutSalpha complex binding, histone H2AXS139 kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: ATR-ATRIP complex, GABA-ergic synapse, Golgi apparatus, PML body, XY body, chromosome, extrinsic component of synaptic vesicle membrane, male germ cell nucleus, nuclear envelope, nucleoplasm, nucleus, postsynapse, site of DNA damage
Pathways: Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Fanconi anemia pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: A0A1L1SSL9, E9QPK4
Entrez ID: 245000
|
Does Knockout of Phf13 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Phf13
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Phf13 (PHD finger protein 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cell division, chromatin organization, chromosome condensation, chromosome segregation, mitotic cell cycle, mitotic chromosome condensation; MF: chromatin binding, chromatin-protein adaptor activity, histone H3K9me2/3 reader activity, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q8K2W6
Entrez ID: 230936
|
Does Knockout of Rps5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Rps5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rps5 (ribosomal protein S5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, regulation of translational fidelity, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, mRNA binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P97461
Entrez ID: 20103
|
Does Knockout of Dazap1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Dazap1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dazap1 (DAZ associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, fibroblast proliferation, maternal placenta development, positive regulation of mRNA splicing, via spliceosome, spermatogenesis; MF: RNA binding, RNA stem-loop binding, mRNA 3'-UTR binding, nucleic acid binding, poly(G) binding, poly(U) RNA binding; CC: cytoplasm, cytosol, male germ cell nucleus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex
Pathways: mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9JII5
Entrez ID: 70248
|
Does Knockout of Actn1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Actn1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Actn1 (actinin, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament bundle assembly, actin filament network formation, actin filament organization, cortical cytoskeleton organization, focal adhesion assembly, muscle cell development, platelet formation, platelet morphogenesis, positive regulation of DNA-templated transcription, postsynapse organization; MF: actin binding, actin filament binding, calcium ion binding, cytoskeletal regulatory protein binding, double-stranded RNA binding, integrin binding, metal ion binding, protein binding, protein domain specific binding, protein homodimerization activity, structural constituent of postsynapse, transcription coactivator activity, transmembrane transporter binding, vinculin binding; CC: Z disc, actin cytoskeleton, actin filament, anchoring junction, brush border, cell junction, cell projection, cell-cell junction, cortical actin cytoskeleton, cortical cytoskeleton, cytoplasm, cytoskeleton, dendritic spine, dense core granule membrane, fascia adherens, focal adhesion, glutamatergic synapse, membrane, plasma membrane, postsynaptic actin cytoskeleton, ruffle, sarcomere, secretory granule, stress fiber, synapse
Pathways: Adherens junction - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions, Focal adhesion - Mus musculus (mouse), Hemostasis, Leukocyte transendothelial migration - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of cytoskeletal remodeling and cell spreading by IPP complex components, Response to elevated platelet cytosolic Ca2+, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Systemic lupus erythematosus - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q7TPR4
Entrez ID: 109711
|
Does Knockout of Dnlz in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Dnlz
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Dnlz (DNL-type zinc finger)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chaperone-mediated protein complex assembly, protein folding, protein import into mitochondrial matrix, protein stabilization; MF: metal ion binding, protein folding chaperone, protein-folding chaperone binding, zinc ion binding; CC: cytosol, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q9D113
Entrez ID: 52838
|
Does Knockout of Serpina9 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Serpina9
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Serpina9 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9D7D2
Entrez ID: 71907
|
Does Knockout of Srrm1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Srrm1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Srrm1 (serine/arginine repetitive matrix 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, mRNA processing, mRNA splicing, via spliceosome, regulation of mRNA splicing, via spliceosome; MF: DNA binding, RNA binding; CC: catalytic step 2 spliceosome, nuclear matrix, nuclear speck, nucleus, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, RHOBTB2 GTPase cycle, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q52KI8
Entrez ID: 51796
|
Does Knockout of Trdn in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Trdn
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Trdn (triadin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, endoplasmic reticulum membrane organization, establishment of localization in cell, heart contraction, intracellular calcium ion homeostasis, negative regulation of release of sequestered calcium ion into cytosol, positive regulation of release of sequestered calcium ion into cytosol, regulation of cardiac muscle cell membrane potential, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, regulation of sequestering of calcium ion, release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, response to bacterium; MF: protein binding, protein-macromolecule adaptor activity, signaling receptor binding; CC: calcium channel complex, cytosol, junctional membrane complex, junctional sarcoplasmic reticulum membrane, membrane, nucleoplasm, plasma membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways: Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Ion channel transport, Ion homeostasis, Muscle contraction, Stimuli-sensing channels, Transport of small molecules
UniProt: E9Q9K5
Entrez ID: 76757
|
Does Knockout of Vmp1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Vmp1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Vmp1 (vacuole membrane protein 1)
Type: protein-coding
Summary: Predicted to enable phospholipid scramblase activity. Involved in autophagy and lipoprotein transport. Acts upstream of or within embryo implantation. Located in phagophore assembly site. Orthologous to human VMP1 (vacuole membrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi organization, autophagosome assembly, autophagosome membrane docking, autophagy, cell adhesion, cell junction assembly, cell-cell adhesion, embryo implantation, lipid transport, lipoprotein transport, mitochondrion-endoplasmic reticulum membrane tethering, organelle localization by membrane tethering, plasma membrane phospholipid scrambling, positive regulation of ATPase-coupled calcium transmembrane transporter activity; MF: phospholipid scramblase activity; CC: autophagosome membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, nucleolus, phagophore assembly site, plasma membrane, vacuolar membrane, vacuole
Pathways: Autophagy - animal - Mus musculus (mouse)
UniProt: Q99KU0
Entrez ID: 75909
|
Does Knockout of Ang2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ang2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ang2 (angiogenin, ribonuclease A family, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, angiotensin-activated signaling pathway, antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, cardiac muscle hypertrophy, cell growth involved in cardiac muscle cell development, cell migration, cellular response to glucose stimulus, cellular response to stress, cytoplasmic translation, defense response to Gram-positive bacterium, gene expression, hematopoietic stem cell proliferation, innate immune response, negative regulation of smooth muscle cell proliferation, negative regulation of translation in response to stress, positive regulation of endothelial cell proliferation, positive regulation of phosphorylation, positive regulation of protein secretion, rRNA transcription, receptor-mediated endocytosis, renal absorption, response to hormone, response to hypoxia, response to yeast, signal transduction, signaling, stress granule assembly, tRNA stabilization; MF: DNA binding, RNA nuclease activity, actin binding, copper ion binding, endonuclease activity, heparin binding, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, peptide binding, protein homodimerization activity, receptor ligand activity, ribosome binding, signaling receptor binding, tRNA-specific ribonuclease activity; CC: actin cytoskeleton, angiogenin-PRI complex, basement membrane, chromosome, cytoplasm, cytoplasmic stress granule, cytoplasmic vesicle, endocytic vesicle, extracellular region, extracellular space, nucleolus, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse)
UniProt: Q64438
Entrez ID: 11731
|
Does Knockout of Haus2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Haus2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Haus2 (HAUS augmin-like complex, subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome cycle, microtubule nucleation, microtubule organizing center organization, spindle assembly; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, microtubule, mitotic spindle microtubule, spindle, spindle microtubule
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9CQS9
Entrez ID: 66296
|
Does Knockout of Prg4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Prg4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Prg4 (proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hematopoietic stem cell proliferation, immune response, negative regulation of interleukin-6 production, regulation of cell population proliferation, vesicle-mediated transport; MF: polysaccharide binding, scavenger receptor activity; CC: extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: Q9JM99
Entrez ID: 96875
|
Does Knockout of Ms4a1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Ms4a1
|
response to virus
|
Microglial Cell Line
|
Gene: Ms4a1 (membrane-spanning 4-domains, subfamily A, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell differentiation, B cell receptor signaling pathway, calcium ion import into cytosol, cell surface receptor signaling pathway, positive regulation of calcium ion import across plasma membrane, protein tetramerization, response to bacterium, store-operated calcium entry; MF: epidermal growth factor receptor binding, identical protein binding, immunoglobulin binding; CC: cell surface, external side of plasma membrane, membrane, nucleoplasm, plasma membrane, plasma membrane raft
Pathways: Hematopoietic cell lineage - Mus musculus (mouse)
UniProt: P19437
Entrez ID: 12482
|
Does Knockout of Oas1e in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Oas1e
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Oas1e (2'-5' oligoadenylate synthetase 1E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cellular response to exogenous dsRNA, cellular response to interferon-alpha, cellular response to interferon-beta, defense response to bacterium, defense response to virus, glucose homeostasis, glucose metabolic process, interleukin-27-mediated signaling pathway, negative regulation of IP-10 production, negative regulation of chemokine (C-X-C motif) ligand 2 production, negative regulation of type I interferon-mediated signaling pathway, negative regulation of viral genome replication, positive regulation of cellular respiration, positive regulation of interferon-beta production, positive regulation of monocyte chemotactic protein-1 production, positive regulation of tumor necrosis factor production, protein complex oligomerization, response to virus, surfactant homeostasis, toll-like receptor 3 signaling pathway, toll-like receptor 4 signaling pathway, type I interferon-mediated signaling pathway; MF: 2'-5'-oligoadenylate synthetase activity, RNA binding, double-stranded RNA binding, nucleotidyltransferase activity; CC: cytoplasm, cytosol, membrane, mitochondrion, nucleoplasm, nucleus, ribosome
Pathways:
UniProt: A0A0J9YV76, Q8C2W3, A0A0J9YV17
Entrez ID: 231699
|
Does Knockout of Il2rb in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Il2rb
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Il2rb (interleukin 2 receptor, beta chain)
Type: protein-coding
Summary: The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytokine-mediated signaling pathway, immunoglobulin mediated immune response, interleukin-15-mediated signaling pathway, interleukin-2-mediated signaling pathway, negative regulation of apoptotic process, positive regulation of phagocytosis; MF: coreceptor activity, cytokine receptor activity, interleukin-15 receptor activity, interleukin-2 binding, interleukin-2 receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Interleukin receptor SHC signaling, Interleukin-15 signaling, Interleukin-2 family signaling, Interleukin-2 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, JAK-STAT signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Measles - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Signal Transduction, Signaling by Interleukins, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P16297
Entrez ID: 16185
|
Does Knockout of Yipf7 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Yipf7
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Yipf7 (Yip1 domain family, member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle fusion with Golgi apparatus; CC: Golgi apparatus, cis-Golgi network, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, membrane, trans-Golgi network
Pathways:
UniProt: Q9JIM5
Entrez ID: 75581
|
Does Knockout of Tmem184b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Tmem184b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tmem184b (transmembrane protein 184b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane
Pathways:
UniProt: Q8BG09
Entrez ID: 223693
|
Does Knockout of Ngdn in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Ngdn
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ngdn (neuroguidin, EIF4E binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of protein localization to plasma membrane, postsynaptic modulation of chemical synaptic transmission, regulation of translation, regulation of translation at postsynapse, ribosomal small subunit biogenesis; CC: axon, cell projection, chromosome, chromosome, centromeric region, cytoplasm, dendrite, filopodium, glutamatergic synapse, mitochondrion, nucleolus, nucleoplasm, nucleus, perforant pathway to dendrate granule cell synapse, postsynapse, small-subunit processome
Pathways:
UniProt: Q9DB96
Entrez ID: 68966
|
Does Knockout of Nop53 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Nop53
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nop53 (NOP53 ribosome biogenesis factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to hypoxia, mitotic G2 DNA damage checkpoint signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein-containing complex assembly, negative regulation of signal transduction by p53 class mediator, negative regulation of transcription by RNA polymerase II, negative regulation of transcription of nucleolar large rRNA by RNA polymerase I, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K63-linked deubiquitination, protein localization to nucleolus, protein localization to nucleoplasm, protein stabilization, rRNA processing, regulation of RIG-I signaling pathway, regulation of aerobic respiration, regulation of apoptotic process, regulation of cell cycle, regulation of protein phosphorylation, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosome biogenesis; MF: 5S rRNA binding, identical protein binding, p53 binding, protein binding; CC: cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus, rDNA heterochromatin
Pathways:
UniProt: Q8BK35
Entrez ID: 68077
|
Does Knockout of Tlr5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Tlr5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tlr5 (toll-like receptor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune response, immune system process, inflammatory response, innate immune response, positive regulation of cytokine production, positive regulation of interleukin-8 production, positive regulation of nitric oxide biosynthetic process, regulation of tumor necrosis factor production, signal transduction, toll-like receptor 5 signaling pathway, toll-like receptor signaling pathway; MF: interleukin-1 receptor binding, pattern recognition receptor activity, protein binding, signaling receptor activity, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Inflammatory bowel disease - Mus musculus (mouse), Legionellosis - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q9JLF7
Entrez ID: 53791
|
Does Knockout of Iah1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Iah1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Iah1 (isoamyl acetate-hydrolyzing esterase 1 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, gene expression, lipid catabolic process, lipid metabolic process; MF: hydrolase activity, hydrolase activity, acting on ester bonds, identical protein binding, molecular_function
Pathways:
UniProt: Q9DB29
Entrez ID: 67732
|
Does Knockout of Magi1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Magi1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Magi1 (membrane associated guanylate kinase, WW and PDZ domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endothelial cell morphogenesis, positive regulation of cell-cell adhesion, signal transduction; MF: ATP binding, alpha-actinin binding, nucleotide binding, protein binding; CC: adherens junction, anchoring junction, bicellular tight junction, cell junction, cell periphery, cell projection, cell-cell junction, cytoplasm, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: Q6RHR9
Entrez ID: 14924
|
Does Knockout of Ikbkg in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 616
|
Knockout
|
Ikbkg
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Ikbkg (inhibitor of kappaB kinase gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell homeostasis, DNA damage response, anoikis, canonical NF-kappaB signal transduction, defense response to bacterium, establishment of vesicle localization, negative regulation of canonical NF-kappaB signal transduction, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of gene expression, positive regulation of macroautophagy, positive regulation of transcription by RNA polymerase II, protein-containing complex assembly, regulation of transcription by RNA polymerase II, tumor necrosis factor-mediated signaling pathway; MF: K63-linked polyubiquitin modification-dependent protein binding, identical protein binding, linear polyubiquitin binding, metal ion binding, peroxisome proliferator activated receptor binding, polyubiquitin modification-dependent protein binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein homodimerization activity, protein-containing complex binding, signaling adaptor activity, transferrin receptor binding, ubiquitin protein ligase binding, zinc ion binding; CC: IkappaB kinase complex, cytoplasm, cytosol, mitotic spindle, nucleus, protein-containing complex, spindle pole, ubiquitin ligase complex
Pathways: Activation of NF-kappaB in B cells, Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Apoptosis - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytosolic DNA-sensing pathway - Mus musculus (mouse), Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, Death Receptor Signaling, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IKK complex recruitment mediated by RIP1, IL-17 signaling pathway - Mus musculus (mouse), IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Interferon Signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, Modulation of host responses by IFN-stimulated genes, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), NOD1/2 Signaling Pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Osteoclast differentiation - Mus musculus (mouse), Ovarian tumor domain proteases, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PKR-mediated signaling, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Primary immunodeficiency - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), RIP-mediated NFkB activation via ZBP1, Ras signaling pathway - Mus musculus (mouse), Regulation of NF-kappa B signaling, Regulation of TNFR1 signaling, Response of endothelial cells to shear stress, SLC15A4:TASL-dependent IRF5 activation, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of immune response proteins, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Signaling by the B Cell Receptor (BCR), Small cell lung cancer - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TAK1-dependent IKK and NF-kappa-B activation , TCR signaling, TNF signaling, TNF signaling pathway - Mus musculus (mouse), TNFR1-induced NF-kappa-B signaling pathway, TRAF6 mediated NF-kB activation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Ub-specific processing proteases, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), ZBP1(DAI) mediated induction of type I IFNs, activated TAK1 mediates p38 MAPK activation
UniProt: O88522
Entrez ID: 16151
|
Does Knockout of Cdx4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Cdx4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cdx4 (caudal type homeobox 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior axis specification, anterior/posterior pattern specification, blood vessel development, cell differentiation, digestive tract development, embryonic pattern specification, labyrinthine layer development, negative regulation of transcription by RNA polymerase II, placenta development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q07424
Entrez ID: 12592
|
Does Knockout of Pcdhb4 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Pcdhb4
|
phagocytosis
|
macrophage
|
Gene: Pcdhb4 (protocadherin beta 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: Q8CE07, Q91XZ6, Q8CBE8
Entrez ID: 93875
|
Does Knockout of Ubxn4 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Ubxn4
|
cell cycle progression
|
breast epithelium
|
Gene: Ubxn4 (UBX domain protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, response to unfolded protein; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear envelope, nucleus
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q8VCH8
Entrez ID: 67812
|
Does Knockout of Gria2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Gria2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gria2 (glutamate receptor, ionotropic, AMPA2 (alpha 2))
Type: protein-coding
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to brain-derived neurotrophic factor stimulus, cellular response to glycine, chemical synaptic transmission, conditioned place preference, establishment of protein localization, excitatory postsynaptic potential, ionotropic glutamate receptor signaling pathway, modulation of chemical synaptic transmission, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of synaptic transmission, protein tetramerization, receptor internalization, regulation of long-term synaptic depression, regulation of postsynaptic membrane potential, regulation of receptor recycling, regulation of synaptic transmission, glutamatergic, synaptic transmission, glutamatergic; MF: AMPA glutamate receptor activity, PDZ domain binding, SNARE binding, amyloid-beta binding, cytoskeletal protein binding, extracellular ligand-gated monoatomic ion channel activity, extracellularly glutamate-gated ion channel activity, glutamate receptor binding, glutamate-gated calcium ion channel activity, glutamate-gated receptor activity, identical protein binding, immunoglobulin binding, ionotropic glutamate receptor binding, kainate selective glutamate receptor activity, ligand-gated monoatomic cation channel activity, ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, monoatomic ion channel activity, protein binding, protein kinase binding, protein-containing complex binding, scaffold protein binding, signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: AMPA glutamate receptor complex, Schaffer collateral - CA1 synapse, asymmetric synapse, axon, cell surface, dendrite, dendrite cytoplasm, dendrite membrane, dendritic shaft, dendritic spine, dendritic spine head, dendritic spine neck, endoplasmic reticulum, external side of plasma membrane, glutamatergic synapse, growth cone, membrane, neuron projection, neuronal cell body, perikaryon, perisynaptic space, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, presynapse, presynaptic active zone membrane, presynaptic membrane, protein-containing complex, somatodendritic compartment, spine synapse, synapse, synaptic membrane, synaptic vesicle, synaptic vesicle membrane, terminal bouton
Pathways: Amphetamine addiction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nicotine addiction - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q4LG64, E9QKC0, G5E8H1, A0A0A6YW90
Entrez ID: 14800
|
Does Knockout of Ndufa6 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Ndufa6
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ndufa6 (NADH:ubiquinone oxidoreductase subunit A6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQZ5
Entrez ID: 67130
|
Does Knockout of Ccdc137 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Ccdc137
|
phagocytosis
|
macrophage
|
Gene: Ccdc137 (coiled-coil domain containing 137)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: chromosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8R0K4
Entrez ID: 67291
|
Does Knockout of Mrpl48 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mrpl48
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrpl48 (mitochondrial ribosomal protein L48)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q8JZS9
Entrez ID: 52443
|
Does Knockout of Dap3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Dap3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Dap3 (death associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic mitochondrial changes, apoptotic process, mitochondrial translation; MF: GTPase activity, hydrolase activity, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrial small ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9ER88
Entrez ID: 65111
|
Does Knockout of Rpl3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Rpl3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rpl3 (ribosomal protein L3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-4, cytoplasmic translation, translation; MF: 5S rRNA binding, RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleolus, nucleus, protein-containing complex, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P27659
Entrez ID: 27367
|
Does Knockout of Mrps22 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Mrps22
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mrps22 (mitochondrial ribosomal protein S22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CXW2
Entrez ID: 64655
|
Does Knockout of Faim in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Faim
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Faim (Fas apoptotic inhibitory molecule)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of canonical NF-kappaB signal transduction, positive regulation of neurogenesis, regulation of signal transduction
Pathways:
UniProt: Q9WUD8
Entrez ID: 23873
|
Does Knockout of Tppp in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Tppp
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Tppp (tubulin polymerization promoting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: astral microtubule organization, cell division, microtubule bundle formation, microtubule nucleation by microtubule organizing center, microtubule polymerization, myelin assembly, negative regulation of tubulin deacetylation, oligodendrocyte development, oligodendrocyte differentiation, positive regulation of myelination, positive regulation of protein polymerization, positive regulation of protein-containing complex assembly, regulation of microtubule cytoskeleton organization; MF: GTPase activity, hydrolase activity, magnesium ion binding, metal ion binding, microtubule binding, protein homodimerization activity, tubulin binding; CC: Golgi apparatus, cytoplasm, cytoskeleton, cytosol, microtubule, microtubule bundle, microtubule organizing center, mitochondrion, mitotic spindle, myelin sheath, nucleus, perinuclear region of cytoplasm, postsynaptic Golgi apparatus, spindle
Pathways:
UniProt: Q7TQD2
Entrez ID: 72948
|
Does Knockout of Cpne7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Cpne7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cpne7 (copine VII)
Type: protein-coding
Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to calcium ion; MF: calcium-dependent phospholipid binding, metal ion binding; CC: cytoplasm, membrane, nucleus, plasma membrane, synapse
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism
UniProt: Q0VE82
Entrez ID: 102278
|
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