prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Scnm1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Scnm1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Scnm1 (sodium channel modifier 1)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Zfp454 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Zfp454
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Zfp454 (zinc finger protein 454)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: Q8BIK0, Q80Y34, Q5NCH7, Q5NCH5
Entrez ID: 237758
|
Does Knockout of Lrfn3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Lrfn3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lrfn3 (leucine rich repeat and fibronectin type III domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, regulation of presynapse assembly, regulation of synaptic membrane adhesion, synaptic membrane adhesion; CC: axon, cell projection, cell surface, dendrite, glutamatergic synapse, membrane, plasma membrane, postsynaptic density membrane, postsynaptic membrane, postsynaptic specialization membrane, presynaptic active zone membrane, presynaptic membrane, synapse
Pathways: Neuronal System, Protein-protein interactions at synapses, Synaptic adhesion-like molecules
UniProt: Q8BLY3
Entrez ID: 233067
|
Does Knockout of Rab11fip4 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Rab11fip4
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Rab11fip4 (RAB11 family interacting protein 4 (class II))
Type: protein-coding
Summary: Predicted to enable protein homodimerization activity and small GTPase binding activity. Predicted to be involved in endocytic recycling and regulation of cytokinesis. Predicted to be located in endosome. Predicted to be active in cleavage furrow; cytoplasmic vesicle; and midbody. Is expressed in several structures, including central nervous system; gut; respiratory system; sensory organ; and skeleton. Orthologous to human RAB11FIP4 (RAB11 family interacting protein 4). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell division, endocytic recycling, neural retina development, positive regulation of G1 to G0 transition, regulation of cell cycle, regulation of cytokinesis; MF: calcium ion binding, metal ion binding, protein homodimerization activity, small GTPase binding; CC: Golgi apparatus, cleavage furrow, cytoplasmic vesicle, endocytic vesicle, endosome, membrane, midbody, perinuclear region of cytoplasm, recycling endosome membrane
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q8BQP8
Entrez ID: 268451
|
Does Knockout of Vps11 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Vps11
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Vps11 (VPS11, CORVET/HOPS core subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, endosomal vesicle fusion, endosome organization, endosome to lysosome transport, intracellular protein transport, negative regulation of intracellular estrogen receptor signaling pathway, organelle fusion, positive regulation of early endosome to late endosome transport, positive regulation of protein catabolic process, protein transport, protein ubiquitination, regulation of organelle assembly, vacuole organization, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: metal ion binding, nucleotide binding, protein binding, protein domain specific binding, protein-macromolecule adaptor activity, syntaxin binding, ubiquitin protein ligase activity, zinc ion binding; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, actin filament, autophagosome, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endocytic vesicle, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, presynaptic active zone, vesicle tethering complex
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q91W86
Entrez ID: 71732
|
Does Knockout of Rnf4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Rnf4
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Rnf4 (ring finger protein 4)
Type: protein-coding
Summary: This gene encodes a small nuclear RING finger protein that mediates ubiquitylation of polysumoylated proteins. Deficiency of the encoded protein in mice leads to embryonic lethality and global DNA hypermethylation. A similar protein in humans is required for arsenic-induced degradation of promyelocytic leukemia protein in acute promyelocytic leukemia. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 10. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: DNA damage response, cellular response to gamma radiation, cellular response to hydroxyurea, cellular response to testosterone stimulus, negative regulation of protein localization to chromatin, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein K6-linked ubiquitination, protein K63-linked ubiquitination, protein autoubiquitination, protein ubiquitination, regulation of kinetochore assembly, regulation of spindle assembly, response to arsenic-containing substance; MF: DNA binding, SUMO polymer binding, TBP-class protein binding, identical protein binding, metal ion binding, nuclear androgen receptor binding, nuclear estrogen receptor binding, nucleosome binding, protein binding, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: PML body, cytoplasm, microtubule end, nuclear body, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Immune System, Processing of DNA double-strand break ends
UniProt: Q9QZS2
Entrez ID: 19822
|
Does Knockout of Pgm3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Pgm3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pgm3 (phosphoglucomutase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: UDP-N-acetylglucosamine biosynthetic process, carbohydrate metabolic process, hemopoiesis, protein N-linked glycosylation, protein O-linked glycosylation, spermatogenesis; MF: intramolecular phosphotransferase activity, isomerase activity, magnesium ion binding, metal ion binding, phosphoacetylglucosamine mutase activity
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, GDP-glucose biosynthesis, Metabolism of proteins, Post-translational protein modification, Synthesis of UDP-N-acetyl-glucosamine, Synthesis of substrates in N-glycan biosythesis, UDP-<i>N</i>-acetyl-D-galactosamine biosynthesis II, UDP-<i>N</i>-acetyl-D-glucosamine biosynthesis II, UDP-glucose conversion, glucose and glucose-1-phosphate degradation, glycogen degradation II, glycogen degradation III, starch degradation
UniProt: Q9CYR6
Entrez ID: 109785
|
Does Knockout of Mcph1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Mcph1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mcph1 (microcephaly, primary autosomal recessive 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone development, cerebral cortex development, establishment of mitotic spindle orientation, mitotic cell cycle, negative regulation of transcription by RNA polymerase II, neuronal stem cell population maintenance, protein localization to centrosome, regulation of centrosome cycle, regulation of chromosome condensation, regulation of gene expression, regulation of inflammatory response; MF: identical protein binding; CC: centrosome, cytoplasm, cytoskeleton
Pathways: Cell Cycle, Cell Cycle, Mitotic, Condensation of Prophase Chromosomes, M Phase, Mitotic Prophase
UniProt: Q7TT79
Entrez ID: 244329
|
Does Knockout of Ager in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Ager
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Ager (advanced glycosylation end product-specific receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, astrocyte activation, astrocyte development, cell adhesion, cell surface receptor signaling pathway via JAK-STAT, cellular response to amyloid-beta, cellular response to oxygen-containing compound, glucose mediated signaling pathway, induction of positive chemotaxis, inflammatory response, learning or memory, microglial cell activation, negative regulation of blood circulation, negative regulation of cell adhesion, negative regulation of cell migration, negative regulation of collagen biosynthetic process, negative regulation of connective tissue replacement involved in inflammatory response wound healing, negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, negative regulation of interleukin-10 production, negative regulation of long-term synaptic depression, negative regulation of long-term synaptic potentiation, negative regulation of multicellular organismal process, negative regulation of signaling, neuron projection development, phagocytosis, positive regulation of DNA metabolic process, positive regulation of DNA-templated DNA replication, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of activated T cell proliferation, positive regulation of amyloid precursor protein catabolic process, positive regulation of apoptotic process, positive regulation of autophagy, positive regulation of cell migration, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of dendritic cell differentiation, positive regulation of double-strand break repair, positive regulation of endothelial cell apoptotic process, positive regulation of endothelin production, positive regulation of epithelial to mesenchymal transition, positive regulation of fibroblast migration, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of heterotypic cell-cell adhesion, positive regulation of interleukin-1 beta production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of locomotion, positive regulation of monocyte chemotactic protein-1 production, positive regulation of monocyte extravasation, positive regulation of neuron apoptotic process, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of p38MAPK cascade, positive regulation of phagocytosis, positive regulation of phagocytosis, engulfment, positive regulation of reactive oxygen species metabolic process, positive regulation of signaling, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of tumor necrosis factor production, positive regulation of type B pancreatic cell apoptotic process, protein localization to membrane, protein localization to plasma membrane, regulation of CD4-positive, alpha-beta T cell activation, regulation of T cell mediated cytotoxicity, regulation of inflammatory response, regulation of long-term synaptic potentiation, regulation of p38MAPK cascade, regulation of spontaneous synaptic transmission, response to amyloid-beta, response to hypoxia, transcytosis, transport across blood-brain barrier; MF: DNA binding, RNA binding, S100 protein binding, advanced glycation end-product binding, amyloid-beta binding, high mobility group box 1 binding, histone binding, identical protein binding, laminin receptor activity, molecular adaptor activity, protein binding, protein-containing complex binding, signaling receptor activity; CC: apical plasma membrane, axon, basal plasma membrane, cell junction, cell projection, cell surface, early endosome, endosome, external side of plasma membrane, extracellular region, extracellular space, fibrillar center, membrane, neuronal cell body, nucleus, phagocytic cup, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Advanced glycosylation endproduct receptor signaling, Alzheimer disease - Mus musculus (mouse), Cytokine Signaling in Immune system, DDX58/IFIH1-mediated induction of interferon-alpha/beta, Diabetic cardiomyopathy - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Lipid and atherosclerosis - Mus musculus (mouse), MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Neutrophil extracellular trap formation - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated NF-kB activation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q62151
Entrez ID: 11596
|
Does Knockout of Cdca5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Cdca5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cdca5 (cell division cycle associated 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, double-strand break repair, mitotic sister chromatid cohesion; MF: protein binding, protein-containing complex binding; CC: chromatin, chromosome, cytoplasm, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Establishment of Sister Chromatid Cohesion, M Phase, MicroRNAs in cancer - Mus musculus (mouse), Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Resolution of Sister Chromatid Cohesion, S Phase, Separation of Sister Chromatids
UniProt: Q9CPY3
Entrez ID: 67849
|
Does Knockout of Pcmtd1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Pcmtd1
|
phagocytosis
|
macrophage
|
Gene: Pcmtd1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination; MF: S-adenosylmethionine-dependent methyltransferase activity, protein-L-isoaspartate (D-aspartate) O-methyltransferase activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul5-RING ubiquitin ligase complex, cytoplasm, membrane
Pathways:
UniProt: P59913
Entrez ID: 319263
|
Does Knockout of Fcgr1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Fcgr1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Fcgr1 (Fc receptor, IgG, high affinity I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Fc-gamma receptor signaling pathway, antibody-dependent cellular cytotoxicity, antigen processing and presentation of exogenous antigen, antigen processing and presentation of exogenous peptide antigen via MHC class I, cell surface receptor signaling pathway, defense response to bacterium, immune system process, innate immune response, phagocytosis, engulfment, phagocytosis, recognition, positive regulation of phagocytosis, positive regulation of phagocytosis, engulfment, positive regulation of tumor necrosis factor production, positive regulation of type III hypersensitivity, positive regulation of type IIa hypersensitivity, receptor-mediated endocytosis, regulation of immune response, response to bacterium; MF: IgG binding, IgG receptor activity, high-affinity IgG receptor activity, leukotriene receptor binding; CC: external side of plasma membrane, membrane, plasma membrane
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, Cross-presentation of soluble exogenous antigens (endosomes), FCGR activation, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Hematopoietic cell lineage - Mus musculus (mouse), Immune System, Innate Immune System, Leishmaniasis - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Role of phospholipids in phagocytosis, Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: P26151
Entrez ID: 14129
|
Does Knockout of Nudcd1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Nudcd1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Nudcd1 (NudC domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q6PIP5
Entrez ID: 67429
|
Does Knockout of Ankrd17 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Ankrd17
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ankrd17 (ankyrin repeat domain 17)
Type: protein-coding
Summary: This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies suggest that this protein is involved in liver development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: blood vessel maturation, defense response to bacterium, endoderm development, immune system process, innate immune response, negative regulation of smooth muscle cell differentiation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of MDA-5 signaling pathway, positive regulation of RIG-I signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell cycle, regulation of DNA replication; MF: RNA binding, chromatin binding, nucleic acid binding; CC: chromatin, cytoplasm, male germ cell nucleus, nuclear membrane, nucleoplasm, nucleus
Pathways:
UniProt: Q99NH0
Entrez ID: 81702
|
Does Knockout of Mrpl54 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Mrpl54
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mrpl54 (mitochondrial ribosomal protein L54)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including brain; brown fat; early conceptus; gonad; and skeleton. Orthologous to human MRPL54 (mitochondrial ribosomal protein L54). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CPW3
Entrez ID: 66047
|
Does Knockout of Etv5 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Etv5
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Etv5 (ets variant 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cellular response to oxidative stress, locomotory behavior, male germ-line stem cell asymmetric division, negative regulation of transcription by RNA polymerase II, neuromuscular synaptic transmission, positive regulation of DNA-templated transcription, positive regulation of glial cell proliferation, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of branching involved in mammary gland duct morphogenesis, regulation of synapse organization, regulation of transcription by RNA polymerase II, skeletal muscle acetylcholine-gated channel clustering; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: nucleoplasm, nucleus, plasma membrane, synapse
Pathways: Prostate cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q9CXC9
Entrez ID: 104156
|
Does Knockout of Mmp9 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Mmp9
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mmp9 (matrix metallopeptidase 9)
Type: protein-coding
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cell migration, cellular response to UV-A, cellular response to cell-matrix adhesion, collagen catabolic process, embryo implantation, endodermal cell differentiation, extracellular matrix organization, heart development, macrophage chemotaxis, modification of synaptic structure, modulating synaptic transmission, negative regulation of apoptotic process, negative regulation of cation transmembrane transport, negative regulation of epithelial cell differentiation involved in kidney development, negative regulation of fibroblast proliferation, negative regulation of intrinsic apoptotic signaling pathway, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of keratinocyte migration, positive regulation of leukocyte migration, positive regulation of release of cytochrome c from mitochondria, positive regulation of synaptic plasticity, positive regulation of vascular associated smooth muscle cell proliferation, protein catabolic process, proteolysis, regulation of multicellular organismal process, regulation of postsynaptic neurotransmitter receptor diffusion trapping, response to amyloid-beta, response to oxidative stress, response to xenobiotic stimulus, skeletal system development, tissue remodeling; MF: endopeptidase activity, fibronectin binding, hydrolase activity, identical protein binding, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein-containing complex binding, serine-type endopeptidase activity, zinc ion binding; CC: Schaffer collateral - CA1 synapse, extracellular matrix, extracellular matrix of synaptic cleft, extracellular region, extracellular space, glutamatergic synapse, postsynaptic density, intracellular component, protein-containing complex
Pathways: Activation of Matrix Metalloproteinases, Assembly of collagen fibrils and other multimeric structures, Axon guidance, Bladder cancer - Mus musculus (mouse), Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, ESR-mediated signaling, Estrogen signaling pathway - Mus musculus (mouse), Extra-nuclear estrogen signaling, Extracellular matrix organization, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Nervous system development, Neutrophil degranulation, Pathways in cancer - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, TNF signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P41245
Entrez ID: 17395
|
Does Knockout of Cep70 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Cep70
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cep70 (centrosomal protein 70)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cilium assembly, regulation of microtubule cytoskeleton organization; MF: gamma-tubulin binding, identical protein binding, molecular_function; CC: centrosome, cytoplasm, cytoskeleton, microtubule organizing center
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q6IQY5
Entrez ID: 68121
|
Does Knockout of Bccip in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Bccip
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Bccip (BRCA2 and CDKN1A interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, establishment of mitotic spindle orientation, microtubule anchoring, microtubule cytoskeleton organization, mitotic spindle assembly, mitotic spindle organization, neuroendocrine cell differentiation; MF: kinase regulator activity, tubulin binding; CC: centriole, centrosome, cytoplasm, cytoskeleton, cytosol, mitotic spindle pole, nuclear cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: Q9CWI3
Entrez ID: 66165
|
Does Knockout of Rad23b in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,541
|
Knockout
|
Rad23b
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rad23b (RAD23 homolog B, nucleotide excision repair protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, UV-damage excision repair, cellular response to interleukin-7, embryonic organ development, nucleotide-excision repair, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of proteasomal ubiquitin-dependent protein catabolic process, spermatogenesis; MF: DNA damage sensor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, damaged DNA binding, polyubiquitin modification-dependent protein binding, proteasome binding, protein binding, transcription cis-regulatory region binding, ubiquitin binding; CC: XPC complex, cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex
Pathways: Asparagine N-linked glycosylation, DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Formation of Incision Complex in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER), Josephin domain DUBs, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: P54728
Entrez ID: 19359
|
Does Knockout of Asl in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Asl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Asl (argininosuccinate lyase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-amino acid metabolic process, L-arginine biosynthetic process, L-arginine biosynthetic process via ornithine, amino acid biosynthetic process, amino acid metabolic process, ammonia assimilation cycle, arginine metabolic process, argininosuccinate metabolic process, liver development, locomotory behavior, positive regulation of nitric oxide biosynthetic process, post-embryonic development, response to nutrient levels, urea cycle; MF: argininosuccinate lyase activity, catalytic activity, identical protein binding, lyase activity, protein binding; CC: cell body fiber, cytosol, mitochondrial outer membrane, neuronal cell body, perikaryon, perinuclear region of cytoplasm
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Arginine biosynthesis - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Urea cycle, arginine biosynthesis IV, citrulline-nitric oxide cycle, superpathway of citrulline metabolism, urea cycle
UniProt: Q91YI0
Entrez ID: 109900
|
Does Knockout of Utp11 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Utp11
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Utp11 (UTP11 small subunit processome component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development, positive regulation of apoptotic process, rRNA processing, ribosomal small subunit biogenesis; CC: cytoplasm, cytosol, extracellular space, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CZJ1
Entrez ID: 67205
|
Does Knockout of Map3k14 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Map3k14
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Map3k14 (mitogen-activated protein kinase kinase kinase 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, cellular response to mechanical stimulus, defense response to virus, immune response, non-canonical NF-kappaB signal transduction; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, fibrillar center, nucleoplasm
Pathways: Adaptive Immune System, Alcoholic liver disease - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CD28 dependent PI3K/Akt signaling, CLEC7A (Dectin-1) signaling, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Co-stimulation by CD28, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Epstein-Barr virus infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Intestinal immune network for IgA production - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), NIK-->noncanonical NF-kB signaling, Osteoclast differentiation - Mus musculus (mouse), Regulation of T cell activation by CD28 family, T cell receptor signaling pathway - Mus musculus (mouse), TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNF signaling pathway - Mus musculus (mouse), TNFR2 non-canonical NF-kB pathway
UniProt: Q9WUL6
Entrez ID: 53859
|
Does Knockout of Zc3h12d in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Zc3h12d
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Zc3h12d (zinc finger CCCH type containing 12D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, mRNA catabolic process, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell proliferation, negative regulation of cell growth; MF: RNA endonuclease activity, endonuclease activity, hydrolase activity, mRNA binding, metal ion binding, nuclease activity, zinc ion binding; CC: P-body, cytoplasm, cytoplasmic ribonucleoprotein granule, nucleoplasm, nucleus
Pathways:
UniProt: Q8BIY3
Entrez ID: 237256
|
Does Knockout of Pim2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Pim2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Pim2 (proviral integration site 2)
Type: protein-coding
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; positive regulation of metabolic process; and protein stabilization. Acts upstream of or within apoptotic mitochondrial changes; negative regulation of apoptotic process; and positive regulation of macroautophagy. Predicted to be active in cytoplasm. Is expressed in several structures, including exocrine gland; genitourinary system; hemolymphoid system gland; nervous system; and nose. Orthologous to human PIM2 (Pim-2 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G1/S transition of mitotic cell cycle, apoptotic mitochondrial changes, apoptotic process, negative regulation of apoptotic process, negative regulation of cell population proliferation, positive regulation of DNA-templated transcription, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of macroautophagy, protein phosphorylation, protein stabilization, regulation of mitotic cell cycle, response to virus; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: Q62070
Entrez ID: 18715
|
Does Knockout of Cc2d2a in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Cc2d2a
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cc2d2a (coiled-coil and C2 domain containing 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axoneme assembly, camera-type eye development, cell projection organization, cilium assembly, determination of left/right symmetry, embryonic brain development, heart development, kidney development, motile cilium assembly, neural tube closure, non-motile cilium assembly, protein localization to ciliary transition zone, smoothened signaling pathway; CC: MKS complex, cell projection, ciliary transition zone, cilium, cytoplasm, cytoskeleton
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q8CFW7
Entrez ID: 231214
|
Does Knockout of Madd in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Madd
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Madd (MAP-kinase activating death domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde synaptic vesicle transport, apoptotic process, execution phase of apoptosis, negative regulation of apoptotic signaling pathway, negative regulation of growth hormone secretion, negative regulation of pancreatic amylase secretion, positive regulation of MAPK cascade, regulation of Rab protein signal transduction, regulation of apoptotic process, regulation of cell cycle, regulation of extrinsic apoptotic signaling pathway, regulation of extrinsic apoptotic signaling pathway via death domain receptors; MF: guanyl-nucleotide exchange factor activity; CC: axon, axon cytoplasm, cell projection, cytoplasm, cytosol, membrane, plasma membrane, synapse, synaptic vesicle
Pathways: Death Receptor Signaling, Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Regulation of TNFR1 signaling, Signal Transduction, TNF signaling, Vesicle-mediated transport
UniProt: Q80U28
Entrez ID: 228355
|
Does Knockout of Ctrb1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ctrb1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ctrb1 (chymotrypsinogen B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: digestion, positive regulation of apoptotic process, protein catabolic process, proteolysis, response to cytokine; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity
Pathways: Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q9CR35
Entrez ID: 66473
|
Does Knockout of Adamts15 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Adamts15
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Adamts15 (ADAM metallopeptidase with thrombospondin type 1 motif 15)
Type: protein-coding
Summary: This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active versicanase enzyme. This gene is located adjacent to a related ADAMTS gene (Adamts8) on chromosome 9. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: extracellular matrix disassembly, extracellular matrix organization, myoblast fusion, proteolysis; MF: endopeptidase activity, extracellular matrix binding, heparin binding, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: cell surface, extracellular matrix, extracellular region, extracellular space
Pathways: Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: P59384
Entrez ID: 235130
|
Does Knockout of Mrpl45 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Mrpl45
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mrpl45 (mitochondrial ribosomal protein L45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D0Q7
Entrez ID: 67036
|
Does Knockout of Cdk5r1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Cdk5r1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cdk5r1 (cyclin dependent kinase 5, regulatory subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled acetylcholine receptor signaling pathway, G1 to G0 transition involved in cell differentiation, axon guidance, axonal fasciculation, brain development, cerebellum development, cerebral cortex radially oriented cell migration, embryo development ending in birth or egg hatching, ephrin receptor signaling pathway, hippocampus development, ionotropic glutamate receptor signaling pathway, layer formation in cerebral cortex, negative regulation of DNA-templated transcription, neuron cell-cell adhesion, neuron differentiation, neuron migration, neuron projection development, positive regulation of MHC class II biosynthetic process, positive regulation of neuron apoptotic process, positive regulation of protein targeting to membrane, positive regulation of tumor necrosis factor-mediated signaling pathway, regulation of actin cytoskeleton organization, regulation of dendritic spine morphogenesis, regulation of microtubule cytoskeleton organization, regulation of synaptic vesicle cycle, rhythmic process, superior olivary nucleus maturation; MF: Hsp90 protein binding, actin binding, actin filament binding, cadherin binding, calcium ion binding, cyclin-dependent protein serine/threonine kinase activator activity, cytoskeletal protein binding, ephrin receptor binding, ionotropic glutamate receptor binding, kinase activity, protease binding, protein binding, protein kinase binding, protein serine/threonine kinase activator activity; CC: axon, cell projection, contractile muscle fiber, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, dendrite, dendritic spine, growth cone, membrane, neuromuscular junction, neuron projection, neuronal cell body, nucleoplasm, nucleus, perikaryon, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, presynapse, protein kinase 5 complex
Pathways: Alzheimer disease - Mus musculus (mouse), Axon guidance, CRMPs in Sema3A signaling, Cocaine addiction - Mus musculus (mouse), Developmental Biology, Gene expression (Transcription), Generic Transcription Pathway, Nervous system development, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Semaphorin interactions, Transcriptional Regulation by TP53
UniProt: P61809
Entrez ID: 12569
|
Does Knockout of Cd6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Cd6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cd6 (CD6 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acute inflammatory response to antigenic stimulus, cell adhesion, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, immunological synapse formation, lipopolysaccharide-mediated signaling pathway, positive regulation of T cell proliferation, positive regulation of cytokine production involved in inflammatory response, response to lipopolysaccharide; MF: identical protein binding, lipopolysaccharide binding, lipoteichoic acid binding, protein binding, protein kinase binding; CC: T cell receptor complex, cell surface, immunological synapse, membrane, plasma membrane
Pathways: Cell adhesion molecules - Mus musculus (mouse)
UniProt: Q61003
Entrez ID: 12511
|
Does Knockout of Ddx3x in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ddx3x
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ddx3x (DEAD box helicase 3, X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, apoptotic process, cell differentiation, cellular response to arsenic-containing substance, cellular response to osmotic stress, cellular response to virus, chromosome segregation, cytoplasmic pattern recognition receptor signaling pathway, cytosolic ribosome assembly, extrinsic apoptotic signaling pathway via death domain receptors, gamete generation, immune system process, inflammatory response, innate immune response, intracellular signal transduction, intrinsic apoptotic signaling pathway, lipid homeostasis, negative regulation of apoptotic process, negative regulation of cell growth, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of gene expression, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of protein-containing complex assembly, negative regulation of translation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of apoptotic process, positive regulation of canonical Wnt signaling pathway, positive regulation of cell growth, positive regulation of gene expression, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of mitochondrial translation, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of protein K63-linked ubiquitination, positive regulation of toll-like receptor 7 signaling pathway, positive regulation of toll-like receptor 8 signaling pathway, positive regulation of transcription by RNA polymerase II, positive regulation of translation, positive regulation of translation in response to endoplasmic reticulum stress, positive regulation of translational initiation, positive regulation of type I interferon production, positive regulation of viral genome replication, primary miRNA processing, protein localization to cytoplasmic stress granule, regulation of translation, response to virus, ribosome biogenesis, stress granule assembly, translational initiation; MF: ATP binding, ATP hydrolysis activity, CTPase activity, DNA binding, DNA helicase activity, GTPase activity, RNA binding, RNA helicase activity, RNA stem-loop binding, RNA strand annealing activity, eukaryotic initiation factor 4E binding, gamma-tubulin binding, helicase activity, hydrolase activity, mRNA 5'-UTR binding, mRNA binding, nucleic acid binding, nucleotide binding, poly(A) binding, primary miRNA binding, protein binding, protein serine/threonine kinase activator activity, ribonucleoside triphosphate phosphatase activity, ribosomal small subunit binding, signaling adaptor activity, transcription factor binding, translation initiation factor binding; CC: NLRP3 inflammasome complex, P granule, canonical inflammasome complex, cell leading edge, cell projection, centrosome, cytoplasm, cytoplasmic stress granule, cytosol, cytosolic small ribosomal subunit, eukaryotic translation initiation factor 3 complex, glutamatergic synapse, lamellipodium, membrane, mitochondrion, nucleus, plasma membrane, postsynaptic density
Pathways: Hepatitis B - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q62167
Entrez ID: 13205
|
Does Knockout of Rfx1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Rfx1
|
cell cycle progression
|
breast epithelium
|
Gene: Rfx1 (regulatory factor X, 1 (influences HLA class II expression))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: P48377
Entrez ID: 19724
|
Does Knockout of Cenph in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Cenph
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cenph (centromere protein H)
Type: protein-coding
Summary: Enables kinetochore binding activity. Predicted to be involved in chromosome segregation and mitotic spindle organization. Predicted to act upstream of or within mitotic cell cycle. Located in kinetochore and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and skin. Orthologous to human CENPH (centromere protein H). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromosome segregation, kinetochore assembly, kinetochore organization, mitotic cell cycle, mitotic spindle organization; MF: kinetochore binding, protein binding; CC: chromosome, chromosome, centromeric region, inner kinetochore, kinetochore, nucleolus, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9QYM8
Entrez ID: 26886
|
Does Knockout of Urod in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Urod
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Urod (uroporphyrinogen decarboxylase)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the conversion of uroporphyrinogen-III to coproporphyrinogen-III, an intermediate step in heme biosynthesis. Homozygous knockout mice for this gene exhibit embryonic lethality. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: cell population proliferation, heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, heme metabolic process, porphyrin-containing compound biosynthetic process, porphyrin-containing compound catabolic process, porphyrin-containing compound metabolic process, protoporphyrinogen IX biosynthetic process, uroporphyrinogen III metabolic process; MF: carboxy-lyase activity, ferrous iron binding, lyase activity, uroporphyrinogen decarboxylase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Heme biosynthesis, Metabolism, Metabolism of porphyrins, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, heme biosynthesis from uroporphyrinogen-III I
UniProt: P70697
Entrez ID: 22275
|
Does Knockout of Kcne2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Kcne2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kcne2 (potassium voltage-gated channel, Isk-related subfamily, gene 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle cell action potential involved in contraction, cellular response to xenobiotic stimulus, establishment of localization in cell, intracellular protein localization, iodide transport, membrane repolarization, membrane repolarization during action potential, membrane repolarization during ventricular cardiac muscle cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, multicellular organismal response to stress, myo-inositol transport, negative regulation of delayed rectifier potassium channel activity, positive regulation of proteasomal protein catabolic process, potassium ion export across plasma membrane, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of heart rate by cardiac conduction, regulation of membrane repolarization, regulation of potassium ion transmembrane transport, regulation of ventricular cardiac muscle cell membrane repolarization, ventricular cardiac muscle cell action potential; MF: delayed rectifier potassium channel activity, identical protein binding, inward rectifier potassium channel activity, potassium channel activity, potassium channel regulator activity, protein binding, transmembrane transporter binding, voltage-gated potassium channel activity, voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; CC: apical plasma membrane, cell surface, membrane, monoatomic ion channel complex, plasma membrane, voltage-gated potassium channel complex
Pathways: Cardiac conduction, Gastric acid secretion - Mus musculus (mouse), Muscle contraction, Phase 2 - plateau phase, Phase 3 - rapid repolarisation
UniProt: Q9D808
Entrez ID: 246133
|
Does Knockout of Cox6c in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Cox6c
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cox6c (cytochrome c oxidase subunit 6C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, oxidative phosphorylation; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, aerobic respiration -- electron donor II
UniProt: Q9CPQ1
Entrez ID: 12864
|
Does Knockout of Chek2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Chek2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Chek2 (checkpoint kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, G2/M transition of mitotic cell cycle, apoptotic process, autophagosome assembly, cell division, cellular response to bisphenol A, cellular response to gamma radiation, cellular response to stress, cellular response to xenobiotic stimulus, double-strand break repair, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, mitotic DNA damage checkpoint signaling, mitotic intra-S DNA damage checkpoint signaling, mitotic spindle assembly, negative regulation of DNA damage checkpoint, positive regulation of DNA-templated transcription, positive regulation of anoikis, positive regulation of autophagosome assembly, protein K63-linked ubiquitination, protein autophosphorylation, protein catabolic process, protein stabilization, regulation of DNA-templated transcription, regulation of autophagosome assembly, regulation of protein catabolic process, response to gamma radiation, response to glycoside, response to oxidative stress, response to starvation, signal transduction in response to DNA damage, thymocyte apoptotic process; MF: ATP binding, identical protein binding, kinase activity, metal ion binding, nucleotide binding, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, ubiquitin protein ligase binding; CC: Golgi apparatus, PML body, chromosome, telomeric region, cytoplasm, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, G1/S DNA Damage Checkpoints, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Stabilization of p53, Transcriptional Regulation by TP53, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, p53 signaling pathway - Mus musculus (mouse), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9Z265
Entrez ID: 50883
|
Does Knockout of Psg21 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Psg21
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Psg21 (pregnancy-specific beta-1-glycoprotein 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, female pregnancy, immune response; CC: cellular_component, external side of plasma membrane
Pathways:
UniProt: S4R1D2, Q9DAV5
Entrez ID: 72242
|
Does Knockout of Usp20 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Usp20
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Usp20 (ubiquitin specific peptidase 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, canonical NF-kappaB signal transduction, endocytosis, negative regulation of canonical NF-kappaB signal transduction, nervous system development, positive regulation of autophagy, protein K48-linked deubiquitination, protein K63-linked deubiquitination, protein deubiquitination, proteolysis, regulation of G protein-coupled receptor signaling pathway; MF: G protein-coupled receptor binding, cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, zinc ion binding; CC: centrosome, cytoplasm, cytoskeleton, endoplasmic reticulum, perinuclear region of cytoplasm
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q8C6M1
Entrez ID: 74270
|
Does Knockout of Sly in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Sly
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Sly (Sycp3 like Y-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A087WRK1, Q810R0, A0A9L6KDV5, A0A087WNQ6
Entrez ID: 382301
|
Does Knockout of Azin1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Azin1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Azin1 (antizyme inhibitor 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: negative regulation of protein catabolic process, polyamine biosynthetic process, polyamine metabolic process, positive regulation of centrosome duplication, positive regulation of epithelial cell proliferation, positive regulation of polyamine transmembrane transport, putrescine biosynthetic process from arginine, via ornithine; MF: catalytic activity, ornithine decarboxylase activator activity, ornithine decarboxylase activity; CC: centrosome, cytoplasm, nucleus
Pathways: Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, Regulation of ornithine decarboxylase (ODC), putrescine biosynthesis III, spermine biosynthesis II
UniProt: O35484
Entrez ID: 54375
|
Does Knockout of Maea in bone marrow cell line causally result in regulation of signal transduction phenotype?
| 1
| 1,785
|
Knockout
|
Maea
|
regulation of signal transduction phenotype
|
bone marrow cell line
|
Gene: Maea (macrophage erythroblast attacher)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell division, cytoskeleton organization, enucleate erythrocyte development, erythrocyte development, erythrocyte maturation, negative regulation of myeloid cell apoptotic process, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: actin binding, metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: GID complex, actin cytoskeleton, actomyosin contractile ring, cytoplasm, cytoskeleton, membrane, nuclear matrix, nucleoplasm, nucleus, plasma membrane, spindle, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: Q4VC33
Entrez ID: 59003
|
Does Knockout of Snip1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Snip1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Snip1 (Smad nuclear interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, miRNA processing, negative regulation of canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, regulation of gene expression, regulatory ncRNA-mediated gene silencing; MF: mRNA binding, transcription regulator inhibitor activity; CC: U2-type precatalytic spliceosome, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8BIZ6
Entrez ID: 76793
|
Does Knockout of Lepr in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Lepr
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lepr (leptin receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, angiogenesis, bone growth, cell surface receptor signaling pathway via STAT, cholesterol metabolic process, cytokine-mediated signaling pathway, eating behavior, energy homeostasis, glial cell proliferation, glucose homeostasis, glycogen metabolic process, leptin-mediated signaling pathway, negative regulation of autophagy, negative regulation of eating behavior, negative regulation of gluconeogenesis, negative regulation of locomotor rhythm, phagocytosis, positive regulation of MAPK cascade, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of bone remodeling, regulation of feeding behavior, regulation of transport, response to leptin, sexual reproduction, signal transduction, system development; MF: cytokine binding, cytokine receptor activity, identical protein binding, leptin receptor activity, peptide hormone binding, protein binding, protein-hormone receptor activity, signaling receptor activity, transmembrane signaling receptor activity; CC: basolateral plasma membrane, external side of plasma membrane, extracellular region, extracellular space, membrane, plasma membrane, receptor complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse)
UniProt: P48356
Entrez ID: 16847
|
Does Knockout of Slc38a2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Slc38a2
|
cell cycle progression
|
breast epithelium
|
Gene: Slc38a2 (solute carrier family 38, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamine import across plasma membrane, L-proline import across plasma membrane, L-serine import across plasma membrane, L-serine transport, acidic amino acid transport, alanine transport, amino acid import, amino acid transmembrane transport, amino acid transport, cellular response to amino acid starvation, cellular response to arsenite(3-), cellular response to mechanical stimulus, cerebral cortex development, female pregnancy, glutamine transport, glycine betaine transport, monoatomic ion transport, neutral amino acid transport, positive regulation of RNA splicing, positive regulation of gene expression, proline transport, regulation of cellular response to stress, regulation of glutamate secretion, neurotransmission, response to muscle activity, sodium ion transmembrane transport, sodium ion transport; MF: L-glutamine transmembrane transporter activity, L-serine transmembrane transporter activity, acidic amino acid transmembrane transporter activity, alanine:sodium symporter activity, amino acid transmembrane transporter activity, amino acid:sodium symporter activity, neutral L-amino acid transmembrane transporter activity, neutral L-amino acid:sodium symporter activity, proline:sodium symporter activity, symporter activity; CC: axon, brush border, cytoplasm, dendrite, membrane, neuronal cell body, plasma membrane, sarcolemma
Pathways: Amino acid transport across the plasma membrane, GABAergic synapse - Mus musculus (mouse), Glutamate Neurotransmitter Release Cycle, Glutamatergic synapse - Mus musculus (mouse), Neuronal System, Neurotransmitter release cycle, Protein digestion and absorption - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transmission across Chemical Synapses, Transport of small molecules
UniProt: Q8CFE6
Entrez ID: 67760
|
Does Knockout of Tubb3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Tubb3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tubb3 (tubulin, beta 3 class III)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, dorsal root ganglion development, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle, netrin-activated signaling pathway, neuron differentiation; MF: GTP binding, GTPase activity, metal ion binding, netrin receptor binding, nucleotide binding, peptide binding, protein binding, structural constituent of cytoskeleton; CC: axon, cell periphery, cell projection, cytoplasm, cytoskeleton, dendrite, filopodium, growth cone, intercellular bridge, lamellipodium, microtubule, microtubule cytoskeleton, mitotic spindle, neuronal cell body
Pathways: Adaptive Immune System, Aggrephagy, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Asparagine N-linked glycosylation, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Cilium Assembly, Cytokine Signaling in Immune system, Developmental Biology, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, G2/M Transition, Gap junction - Mus musculus (mouse), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hedgehog 'off' state, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, L1CAM interactions, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, Recruitment of NuMA to mitotic centrosomes, Recycling pathway of L1, Resolution of Sister Chromatid Cohesion, Salmonella infection - Mus musculus (mouse), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9ERD7
Entrez ID: 22152
|
Does Knockout of Cbfb in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Cbfb
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cbfb (core binding factor beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell maturation, definitive hemopoiesis, lymphocyte differentiation, myeloid cell differentiation, negative regulation of CD4-positive, alpha-beta T cell differentiation, negative regulation of transcription by RNA polymerase II, ossification, osteoblast differentiation, positive regulation of CD8-positive, alpha-beta T cell differentiation, positive regulation of transcription by RNA polymerase II, protein polyubiquitination, regulation of transcription by RNA polymerase II; MF: DNA binding, protein binding, sequence-specific DNA binding, transcription coactivator activity; CC: core-binding factor complex, nucleoplasm, nucleus, protein-containing complex
Pathways: ESR-mediated signaling, Estrogen-dependent gene expression, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs), RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, RUNX1 regulates estrogen receptor mediated transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, RUNX1 regulates transcription of genes involved in BCR signaling, RUNX1 regulates transcription of genes involved in differentiation of HSCs, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells, RUNX1 regulates transcription of genes involved in interleukin signaling, RUNX2 regulates bone development, RUNX3 regulates p14-ARF, Regulation of RUNX1 Expression and Activity, Regulation of RUNX3 expression and activity, Signal Transduction, Signaling by Nuclear Receptors, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3
UniProt: Q08024
Entrez ID: 12400
|
Does Knockout of Mkrn3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Mkrn3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mkrn3 (makorin, ring finger protein, 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein polyubiquitination, protein ubiquitination; MF: identical protein binding, metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: Q60764
Entrez ID: 22652
|
Does Knockout of Glrx3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Glrx3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Glrx3 (glutaredoxin 3)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and protein kinase C binding activity. Involved in negative regulation of cardiac muscle hypertrophy and regulation of the force of heart contraction. Located in Z disc. Is expressed in several structures, including brain; egg cylinder; genitourinary system; gut; and white fat. Orthologous to human GLRX3 (glutaredoxin 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: [2Fe-2S] cluster assembly, cell redox homeostasis, intracellular iron ion homeostasis, iron-sulfur cluster assembly, negative regulation of cardiac muscle hypertrophy, regulation of the force of heart contraction; MF: identical protein binding, iron-sulfur cluster binding, metal ion binding, protein binding, protein kinase C binding; CC: Z disc, cell cortex, cytoplasm, cytosol, dendrite, iron-sulfur cluster assembly complex, nucleus
Pathways:
UniProt: Q9CQM9
Entrez ID: 30926
|
Does Knockout of Pcca in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Pcca
|
cell cycle progression
|
breast epithelium
|
Gene: Pcca (propionyl-Coenzyme A carboxylase, alpha polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid catabolic process, lipid metabolic process; MF: ATP binding, enzyme binding, ligase activity, metal ion binding, nucleotide binding, propionyl-CoA carboxylase activity; CC: catalytic complex, mitochondrial matrix, mitochondrion
Pathways: Biotin transport and metabolism, Fatty acid metabolism, Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Mitochondrial Fatty Acid Beta-Oxidation, Propanoate metabolism - Mus musculus (mouse), Propionyl-CoA catabolism, Valine, leucine and isoleucine degradation - Mus musculus (mouse), isoleucine degradation, methylmalonyl pathway, superpathway of methionine degradation, valine degradation
UniProt: Q91ZA3
Entrez ID: 110821
|
Does Knockout of Ilvbl in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Ilvbl
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ilvbl (ilvB (bacterial acetolactate synthase)-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-valine biosynthetic process, fatty acid alpha-oxidation, fatty acid metabolic process, isoleucine biosynthetic process, lipid metabolic process; MF: acetolactate synthase activity, catalytic activity, flavin adenine dinucleotide binding, lyase activity, magnesium ion binding, metal ion binding, thiamine pyrophosphate binding; CC: acetolactate synthase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q8BU33
Entrez ID: 216136
|
Does Knockout of Slc17a5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Slc17a5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc17a5 (solute carrier family 17 (anion/sugar transporter), member 5)
Type: protein-coding
Summary: Enables D-glucuronate transmembrane transporter activity. Involved in neurotransmitter loading into synaptic vesicle. Acts upstream of or within response to bacterium. Located in cytoplasmic vesicle and plasma membrane. Is active in glutamatergic synapse; lysosomal membrane; and synaptic vesicle membrane. Is expressed in several structures, including gut; liver; metanephros; nervous system; and sensory organ epithelium. Used to study lysosomal storage disease and sialuria. Human ortholog(s) of this gene implicated in sialuria. Orthologous to human SLC17A5 (solute carrier family 17 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: D-glucuronate transmembrane transport, amino acid transport, carboxylic acid transport, neurotransmitter loading into synaptic vesicle, response to bacterium, sialic acid transport, transmembrane transport; MF: D-glucuronate transmembrane transporter activity, sialic acid transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, cytoplasmic vesicle, cytosol, glutamatergic synapse, lysosomal membrane, lysosome, membrane, plasma membrane, synapse, synaptic vesicle membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Glycosaminoglycan metabolism, Hyaluronan degradation, Hyaluronan metabolism, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, Organic anion transport by SLC5/17/25 transporters, Post-translational protein modification, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis, Transport of small molecules
UniProt: Q8BN82
Entrez ID: 235504
|
Does Knockout of Slc26a6 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Slc26a6
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slc26a6 (solute carrier family 26, member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiotensin-activated signaling pathway, bicarbonate transport, cellular response to cAMP, cellular response to fructose stimulus, cellular response to type II interferon, chloride transmembrane transport, chloride transport, epithelial fluid transport, establishment of localization in cell, estrous cycle, formate transport, intestinal absorption, intracellular pH elevation, mannitol transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, oxalate transport, oxalic acid secretion, positive regulation of dipeptide transmembrane transport, protein kinase C signaling, regulation of intracellular pH, sperm capacitation, sulfate transmembrane transport, transepithelial chloride transport, transepithelial transport, transmembrane transport; MF: PDZ domain binding, antiporter activity, bicarbonate transmembrane transporter activity, chloride channel activity, chloride transmembrane transporter activity, chloride:bicarbonate antiporter activity, efflux transmembrane transporter activity, formate transmembrane transporter activity, identical protein binding, oxalate transmembrane transporter activity, protein binding, secondary active sulfate transmembrane transporter activity, solute:inorganic anion antiporter activity, sulfate transmembrane transporter activity, sulfate:bicarbonate antiporter activity; CC: apical plasma membrane, basolateral plasma membrane, brush border membrane, chloride channel complex, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, endoplasmic reticulum, membrane, plasma membrane, sperm midpiece, vesicle, vesicle membrane
Pathways: Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Inorganic anion exchange by SLC26 transporters, Mineral absorption - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Transport of small molecules
UniProt: Q8CIW6
Entrez ID: 171429
|
Does Knockout of Tpst2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Tpst2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tpst2 (protein-tyrosine sulfotransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fusion of sperm to egg plasma membrane involved in single fertilization, peptidyl-tyrosine sulfation, prevention of polyspermy; MF: protein homodimerization activity, protein-tyrosine sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi lumen, Golgi membrane, endoplasmic reticulum, membrane, trans-Golgi network
Pathways: Biological oxidations, Cytosolic sulfonation of small molecules, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism, Metabolism of proteins, Phase II - Conjugation of compounds, Post-translational protein modification
UniProt: O88856
Entrez ID: 22022
|
Does Knockout of Ankrd13a in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Ankrd13a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ankrd13a (ankyrin repeat domain 13a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of protein localization to endosome, negative regulation of receptor internalization; MF: ubiquitin-modified protein reader activity; CC: cytoplasm, endosome, late endosome, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q80UP5
Entrez ID: 68420
|
Does Knockout of Bcas2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Bcas2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Bcas2 (BCAS2 pre-mRNA processing factor)
Type: protein-coding
Summary: Acts upstream of or within several processes, including alternative mRNA splicing, via spliceosome; ovarian follicle development; and spindle assembly. Part of Prp19 complex. Is expressed in several structures, including central nervous system; early conceptus; oocyte; peripheral nervous system ganglion; and submandibular gland primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, oocyte development, oogenesis, ovarian follicle development, protein catabolic process, spindle assembly; CC: DNA replication factor A complex, Prp19 complex, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, centrosome, nuclear speck, nucleolus, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9D287
Entrez ID: 68183
|
Does Knockout of Ints10 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Ints10
|
cell cycle progression
|
breast epithelium
|
Gene: Ints10 (integrator complex subunit 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, snRNA processing; CC: INTAC complex, integrator complex, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q8K2A7
Entrez ID: 70885
|
Does Knockout of Col4a1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Col4a1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Col4a1 (collagen, type IV, alpha 1)
Type: protein-coding
Summary: This gene encodes the alpha-1 subunit of the type IV collagens, an essential component of basement membranes. The encoded protein forms a triple helical heterotrimer comprised of two alpha-1 and one alpha-2 subunits that assembles into a type IV collagen network. This gene is located adjacent to the gene encoding alpha-2 subunit. Mice lacking both the alpha-1 and alpha-2 subunits of collagen IV die in utero due to structural deficiencies in the basement membranes and certain mutations in this gene cause perinatal cerebral hemorrhage and porencephaly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: angiogenesis, basement membrane organization, blood vessel morphogenesis, brain development, branching involved in blood vessel morphogenesis, cellular response to amino acid stimulus, collagen-activated tyrosine kinase receptor signaling pathway, epithelial cell differentiation, neuromuscular junction development, renal tubule morphogenesis, retinal blood vessel morphogenesis; MF: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, platelet-derived growth factor binding; CC: basement membrane, collagen trimer, collagen type IV trimer, extracellular matrix, extracellular region, extracellular space
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Crosslinking of collagen fibrils, Degradation of the extracellular matrix, Developmental Biology, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Fibronectin matrix formation, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Integrin cell surface interactions, Laminin interactions, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Small cell lung cancer - Mus musculus (mouse)
UniProt: P02463
Entrez ID: 12826
|
Does Knockout of Krtap13-1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Krtap13-1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Krtap13-1 (keratin associated protein 13-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q8K198
Entrez ID: 268905
|
Does Knockout of Rbm20 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Rbm20
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rbm20 (RNA binding motif protein 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, heart formation, mRNA processing, negative regulation of mRNA splicing, via spliceosome, positive regulation of RNA splicing, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome, regulation of mRNA splicing, via spliceosome, spliceosome-depend formation of circular RNA; MF: RNA binding, mRNA binding, metal ion binding, nucleic acid binding, pre-mRNA intronic binding, splicing factor binding, zinc ion binding; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, nucleus
Pathways:
UniProt: Q3UQS8
Entrez ID: 73713
|
Does Knockout of Asf1a in Lung Cancer Cell Line causally result in tumorigenicity?
| 1
| 1,089
|
Knockout
|
Asf1a
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Asf1a (anti-silencing function 1A histone chaperone)
Type: protein-coding
Summary: Enables chromatin binding activity. Acts upstream of or within muscle cell differentiation and osteoblast differentiation. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in chromatin; nucleus; and site of double-strand break. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and submandibular gland primordium. Orthologous to human ASF1A (anti-silencing function 1A histone chaperone). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, DNA replication-dependent chromatin assembly, chromatin organization, double-strand break repair via homologous recombination, muscle cell differentiation, nucleosome assembly, osteoblast differentiation, protein localization to chromatin, replication fork processing; MF: chromatin binding, histone binding, histone chaperone activity; CC: chromatin, chromosome, nucleoplasm, nucleus, protein-containing complex, site of double-strand break
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, DNA Damage/Telomere Stress Induced Senescence, Formation of Senescence-Associated Heterochromatin Foci (SAHF)
UniProt: Q9CQE6
Entrez ID: 66403
|
Does Knockout of Padi6 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Padi6
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Padi6 (peptidyl arginine deiminase, type VI)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasm organization, cytoskeleton organization, embryonic cleavage, epigenetic programming in the zygotic pronuclei, in utero embryonic development, intracellular protein localization, protein storage, regulation of translation by machinery localization; MF: calcium ion binding, identical protein binding, protein binding, protein-arginine deiminase activity, structural constituent of cytoplasmic lattice, tubulin binding; CC: cortical granule, cytoplasm, cytoplasmic lattice, cytoplasmic vesicle, intermediate filament cytoskeleton, nucleus, ooplasm
Pathways: Chromatin modifying enzymes, Chromatin organization, protein citrullination
UniProt: Q8K3V4
Entrez ID: 242726
|
Does Knockout of Emc3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Emc3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Emc3 (ER membrane protein complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein insertion into ER membrane by stop-transfer membrane-anchor sequence, tail-anchored membrane protein insertion into ER membrane; MF: membrane insertase activity; CC: EMC complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q99KI3
Entrez ID: 66087
|
Does Knockout of Rhox10 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Rhox10
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rhox10 (reproductive homeobox 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuron development, positive regulation of gene expression, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q4TU83
Entrez ID: 434769
|
Does Knockout of Gjb5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Gjb5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gjb5 (gap junction protein, beta 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell communication, cell-cell signaling, labyrinthine layer morphogenesis, spongiotrophoblast differentiation, transmembrane transport, trophoblast giant cell differentiation; CC: anchoring junction, connexin complex, gap junction, membrane, plasma membrane
Pathways: Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q02739
Entrez ID: 14622
|
Does Knockout of Coasy in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Coasy
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Coasy (Coenzyme A synthase)
Type: protein-coding
Summary: This gene encodes the bifunctional protein coenzyme A (CoA) synthase which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this protein catalyzes the conversion of phosphopantetheine into dephospho-CoA while its dephospho-CoA kinase domain completes the final step by phosphorylating dephospho-CoA to form CoA. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: coenzyme A biosynthetic process; MF: ATP binding, catalytic activity, dephospho-CoA kinase activity, kinase activity, nucleotide binding, nucleotidyltransferase activity, pantetheine-phosphate adenylyltransferase activity, transferase activity; CC: cytoplasm, mitochondrial matrix, mitochondrial outer membrane, mitochondrion
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q9DBL7
Entrez ID: 71743
|
Does Knockout of Trpm4 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Trpm4
|
response to virus
|
Microglial Cell Line
|
Gene: Trpm4 (transient receptor potential cation channel, subfamily M, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, cellular response to ATP, dendritic cell chemotaxis, immune system process, inorganic cation transmembrane transport, long-term memory, membrane depolarization during AV node cell action potential, membrane depolarization during Purkinje myocyte cell action potential, membrane depolarization during bundle of His cell action potential, metal ion transport, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of bone mineralization, negative regulation of osteoblast differentiation, positive regulation of adipose tissue development, positive regulation of atrial cardiac muscle cell action potential, positive regulation of canonical Wnt signaling pathway, positive regulation of cell population proliferation, positive regulation of cytosolic calcium ion concentration, positive regulation of fat cell differentiation, positive regulation of heart rate, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization, positive regulation of vasoconstriction, protein homotetramerization, protein sumoylation, regulation of T cell cytokine production, regulation of heart rate by cardiac conduction, regulation of membrane potential, regulation of ventricular cardiac muscle cell action potential, sodium ion import across plasma membrane, transmembrane transport; MF: ATP binding, calcium channel activity, calcium ion binding, calcium-activated cation channel activity, calmodulin binding, identical protein binding, metal ion binding, monoatomic cation channel activity, monoatomic ion channel activity, nucleotide binding, voltage-gated monoatomic ion channel activity; CC: Golgi apparatus, endoplasmic reticulum, membrane, neuronal cell body, nucleoplasm, plasma membrane, sodium channel complex
Pathways: Insulin secretion - Mus musculus (mouse), Ion channel transport, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q7TN37
Entrez ID: 68667
|
Does Knockout of Gal3st1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Gal3st1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Gal3st1 (galactose-3-O-sulfotransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: galactosylceramide biosynthetic process, galactosylceramide metabolic process, glycerolipid metabolic process, glycolipid biosynthetic process, lipid metabolic process, myelination, spermatogenesis, sphingolipid metabolic process; MF: galactose 3-O-sulfotransferase activity, galactosylceramide sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Ether lipid metabolism - Mus musculus (mouse), Glycosphingolipid biosynthesis, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse)
UniProt: Q9JHE4
Entrez ID: 53897
|
Does Knockout of Pnma2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Pnma2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Pnma2 (paraneoplastic antigen MA2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, nucleolus, nucleus
Pathways:
UniProt: Q8BHK0
Entrez ID: 239157
|
Does Knockout of Cypt2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Cypt2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cypt2 (cysteine-rich perinuclear theca 2)
Type: protein-coding
Summary: cysteine-rich perinuclear theca 2
Gene Ontology:
Pathways:
UniProt: Q8CH23, Q6P924, A0A9L6KE70
Entrez ID: 245566
|
Does Knockout of Fabp3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Fabp3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fabp3 (fatty acid binding protein 3, muscle and heart)
Type: protein-coding
Summary: Predicted to enable cytoskeletal protein binding activity; long-chain fatty acid binding activity; and long-chain fatty acid transmembrane transporter activity. Involved in several processes, including cholesterol homeostasis; phospholipid homeostasis; and positive regulation of long-chain fatty acid import into cell. Acts upstream of or within brown fat cell differentiation and regulation of phosphatidylcholine biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human FABP3 (fatty acid binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: brown fat cell differentiation, cholesterol homeostasis, fatty acid metabolic process, intracellular lipid transport, long-chain fatty acid transport, phospholipid homeostasis, positive regulation of long-chain fatty acid import into cell, positive regulation of phospholipid biosynthetic process, regulation of fatty acid oxidation, regulation of phosphatidylcholine biosynthetic process, response to fatty acid, response to insulin, response to xenobiotic stimulus; MF: cytoskeletal protein binding, fatty acid binding, icosatetraenoic acid binding, lipid binding, long-chain fatty acid binding, long-chain fatty acid transmembrane transporter activity, oleic acid binding; CC: cytoplasm, cytosol, extracellular space, nucleus, sarcoplasm
Pathways: Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), Triglyceride catabolism, Triglyceride metabolism
UniProt: P11404
Entrez ID: 14077
|
Does Knockout of Cubn in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Cubn
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cubn (cubilin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol metabolic process, cobalamin catabolic process, cobalamin metabolic process, cobalamin transport, endocytic hemoglobin import into cell, establishment of localization in cell, in utero embryonic development, lipid metabolic process, lipoprotein transport, protein transport, receptor-mediated endocytosis, response to bacterium, response to nutrient, steroid metabolic process; MF: calcium ion binding, cargo receptor activity, cobalamin binding, hemoglobin binding, identical protein binding, metal ion binding, protein binding, protein homodimerization activity, signaling receptor activity; CC: Golgi apparatus, Golgi-associated vesicle, apical part of cell, apical plasma membrane, brush border, brush border membrane, cell projection membrane, clathrin-coated pit, coated vesicle, cytoplasm, endocytic vesicle, endocytic vesicle membrane, endoplasmic reticulum, endosome, extracellular exosome, lysosomal lumen, lysosomal membrane, lysosome, membrane, microvillus membrane, plasma membrane, protein-containing complex, receptor complex
Pathways: Vitamin digestion and absorption - Mus musculus (mouse)
UniProt: Q9JLB4
Entrez ID: 65969
|
Does Knockout of Clptm1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Clptm1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Clptm1 (cleft lip and palate associated transmembrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, regulation of T cell differentiation in thymus, regulation of postsynaptic membrane neurotransmitter receptor levels; MF: GABA receptor binding, molecular_function; CC: GABA-ergic synapse, endomembrane system, external side of plasma membrane, membrane
Pathways:
UniProt: Q8VBZ3
Entrez ID: 56457
|
Does Knockout of Wdr74 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Wdr74
|
cell cycle progression
|
breast epithelium
|
Gene: Wdr74 (WD repeat domain 74)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA metabolic process, blastocyst formation, rRNA processing, ribosomal large subunit biogenesis; CC: nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q8VCG3
Entrez ID: 107071
|
Does Knockout of Ccnd3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ccnd3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ccnd3 (cyclin D3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, T cell proliferation, cell division, hyaluronan biosynthetic process, negative regulation of transcription by RNA polymerase II, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of cell population proliferation, regulation of cell cycle, regulation of cell population proliferation, response to peptide hormone, signal transduction; MF: cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein binding, protein kinase binding, protein serine/threonine kinase activator activity; CC: cyclin D3-CDK4 complex, cyclin D3-CDK6 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, microtubule organizing center, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cyclin D associated events in G1, Drug-mediated inhibition of CDK4/CDK6 activity, Epstein-Barr virus infection - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), G1 Phase, Gene expression (Transcription), Generic Transcription Pathway, Hippo signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK6/MAPK4 signaling, Measles - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of RUNX1 Expression and Activity, Signal Transduction, Transcriptional regulation by RUNX1, Viral carcinogenesis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P30282
Entrez ID: 12445
|
Does Knockout of Mroh1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Mroh1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Mroh1 (maestro heat-like repeat family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lysosome fission; MF: membrane destabilizing activity, molecular_function; CC: cytoplasm, lysosomal membrane, lysosome, membrane
Pathways:
UniProt: E0CZ22
Entrez ID: 223658
|
Does Knockout of Lrch2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Lrch2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Lrch2 (leucine-rich repeats and calponin homology (CH) domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UMG5
Entrez ID: 210297
|
Does Knockout of Mlph in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Mlph
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mlph (melanophilin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, melanocyte differentiation, melanosome localization, pigmentation, protein targeting; MF: actin binding, metal ion binding, microtubule plus-end binding, molecular adaptor activity, myosin V binding, myosin binding, protein binding, protein-macromolecule adaptor activity, small GTPase binding, zinc ion binding; CC: actin cytoskeleton, cortical actin cytoskeleton, cytoplasm, dendrite, melanosome, microtubule organizing center, perinuclear region of cytoplasm, stress fiber, unconventional myosin complex
Pathways: Developmental Biology, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Regulation of MITF-M-dependent genes involved in pigmentation
UniProt: Q91V27
Entrez ID: 171531
|
Does Knockout of Cntd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Cntd1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cntd1 (cyclin N-terminal domain containing 1)
Type: protein-coding
Summary: Involved in regulation of meiotic cell cycle. Acts upstream of or within reciprocal meiotic recombination and spermatogenesis. Located in chromosome. Orthologous to human CNTD1 (cyclin N-terminal domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: meiotic cell cycle, reciprocal meiotic recombination, regulation of meiotic cell cycle, spermatogenesis; CC: chromosome, cytoplasm, nucleus, site of double-strand break
Pathways:
UniProt: Q9D995
Entrez ID: 68107
|
Does Knockout of Gpnmb in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Gpnmb
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gpnmb (glycoprotein (transmembrane) nmb)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, cell adhesion, cell-cell signaling, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell activation, negative regulation of T cell proliferation, negative regulation of cytokine production, negative regulation of tumor necrosis factor production, osteoblast differentiation, positive regulation of ERK1 and ERK2 cascade, positive regulation of cell migration, regulation of tissue remodeling, signal transduction; MF: heparin binding, integrin binding, receptor ligand activity, syndecan binding; CC: cytoplasmic vesicle, early endosome membrane, endosome, melanosome membrane, membrane, plasma membrane
Pathways: PTK6 promotes HIF1A stabilization, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6
UniProt: Q99P91
Entrez ID: 93695
|
Does Knockout of Gpr25 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Gpr25
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gpr25 (G protein-coupled receptor 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, chemokine-mediated signaling pathway, leukocyte chemotaxis, lymphocyte chemotaxis, lymphocyte migration into lymphoid organs, signal transduction; MF: C-X-C chemokine receptor activity, G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways: G alpha (s) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: P0C5I1
Entrez ID: 383563
|
Does Knockout of Grm3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Grm3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Grm3 (glutamate receptor, metabotropic 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled glutamate receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cellular response to stress, gene expression, modulation of chemical synaptic transmission, postsynaptic modulation of chemical synaptic transmission, regulation of sensory perception of pain, regulation of synaptic transmission, glutamatergic, sensory perception of pain, signal transduction, synaptic transmission, glutamatergic; MF: G protein-coupled receptor activity, calcium channel regulator activity, group II metabotropic glutamate receptor activity, scaffold protein binding; CC: astrocyte projection, axon, dendritic spine, glutamatergic synapse, membrane, neuron projection, plasma membrane, postsynaptic density, postsynaptic membrane, presynaptic active zone, presynaptic membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), Cocaine addiction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Glutamatergic synapse - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q9QYS2
Entrez ID: 108069
|
Does Knockout of Ltb in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Ltb
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ltb (lymphotoxin B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, gene expression, immune response, lymph node development, positive regulation of canonical NF-kappaB signal transduction, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of interleukin-12 production, skin development; MF: cytokine activity, tumor necrosis factor receptor binding; CC: extracellular space, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, NF-kappa B signaling pathway - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNFR2 non-canonical NF-kB pathway
UniProt: P41155
Entrez ID: 16994
|
Does Knockout of Dmd in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Dmd
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dmd (dystrophin, muscular dystrophy)
Type: protein-coding
Summary: This gene encodes a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers in skeletal and cardiac muscles. The encoded protein, dystrophin, is part of the dystrophin-glycoprotein complex, which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. This protein is required for proper development and organization of myofibers as contractile units in striated muscles. Mutations in the human gene cause Duchenne and Becker Muscular Dystrophies and a form of heart disease called DMD-associated dilated cardiomyopathy. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: apoptotic process, bone development, cardiac muscle cell action potential, cardiac muscle contraction, cell differentiation, cerebral cortex development, connective tissue development, determination of adult lifespan, establishment of blood-nerve barrier, establishment of glial blood-brain barrier, gene expression, inflammatory response, intracellular protein localization, limb development, multicellular organism growth, muscle cell cellular homeostasis, muscle cell development, muscle cell differentiation, muscle organ development, myotube cell development, negative regulation of ERK1 and ERK2 cascade, negative regulation of neuron differentiation, neuron development, neuron differentiation, neuron projection morphogenesis, nucleus localization, olfactory nerve structural organization, peptide biosynthetic process, positive regulation of cell population proliferation, positive regulation of cell-matrix adhesion, positive regulation of neuron differentiation, positive regulation of neuron projection development, protein-containing complex assembly, reactive oxygen species biosynthetic process, regulation of DNA-templated transcription, regulation of calcium ion transmembrane transport, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of cellular response to growth factor stimulus, regulation of gene expression, regulation of heart rate, regulation of membrane potential, regulation of muscle system process, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, regulation of skeletal muscle contraction, regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion, regulation of sodium ion transmembrane transport, response to denervation involved in regulation of muscle adaptation, response to muscle stretch, response to xenobiotic stimulus, skeletal muscle tissue development, skeletal muscle tissue regeneration, striated muscle cell development, striated muscle contraction, synaptic signaling, synaptic transmission, cholinergic, walking behavior; MF: PDZ domain binding, actin binding, dystroglycan binding, integrin binding, lamin binding, metal ion binding, myosin binding, nitric-oxide synthase binding, protein binding, protein-containing complex binding, structural constituent of muscle, vinculin binding, zinc ion binding; CC: GABA-ergic synapse, Z disc, astrocyte projection, axon, cell junction, cell projection, cell surface, cell-substrate junction, costamere, cytoplasm, cytoskeleton, dystrophin-associated glycoprotein complex, filopodium, filopodium membrane, lamellipodium, matrix side of mitochondrial inner membrane, membrane, membrane raft, mitochondrial outer membrane, myofibril, neurofilament, neuron projection terminus, neuronal cell body, nucleus, perinuclear region of cytoplasm, plasma membrane, plasma membrane bounded cell projection, postsynapse, postsynaptic density, postsynaptic membrane, postsynaptic specialization, protein-containing complex, ribosome, sarcolemma, secretory granule, synapse, synaptic vesicle membrane
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Hypertrophic cardiomyopathy - Mus musculus (mouse), Muscle contraction, Non-integrin membrane-ECM interactions, Striated Muscle Contraction, Viral myocarditis - Mus musculus (mouse)
UniProt: P11531
Entrez ID: 13405
|
Does Knockout of Smg7 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Smg7
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Smg7 (SMG7 nonsense mediated mRNA decay factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; MF: protein phosphatase 2A binding, telomerase RNA binding, telomeric DNA binding; CC: cytoplasm, cytosol, nucleus, telomerase holoenzyme complex
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q5RJH6
Entrez ID: 226517
|
Does Knockout of Tollip in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Tollip
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tollip (toll interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, epithelial cell differentiation, immune system process, inflammatory response, innate immune response, interleukin-1-mediated signaling pathway, phosphorylation, positive regulation of protein sumoylation, protein localization to endosome, signal transduction, ubiquitin-dependent protein catabolic process; MF: SUMO binding, Toll-like receptor binding, interleukin-1, type I receptor binding, kinase binding, molecular adaptor activity, protein binding, ubiquitin binding, ubiquitin conjugating enzyme binding, ubiquitin protein ligase binding; CC: cytoplasm, early endosome, endosome, nuclear body, perinuclear region of cytoplasm, protein-containing complex
Pathways: Cytokine Signaling in Immune system, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Neutrophil degranulation, Signaling by Interleukins, Toll-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q9QZ06
Entrez ID: 54473
|
Does Knockout of Prr15l in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Prr15l
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Prr15l (proline rich 15-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8JZM2
Entrez ID: 217138
|
Does Knockout of Msl3l2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Msl3l2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Msl3l2 (MSL3 like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, regulation of DNA-templated transcription; MF: DNA binding, histone H4K16ac reader activity, histone reader activity; CC: MSL complex, NuA4 histone acetyltransferase complex, nucleus
Pathways:
UniProt: G3X992
Entrez ID: 73390
|
Does Knockout of Dmpk in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Dmpk
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dmpk (dystrophia myotonica-protein kinase)
Type: protein-coding
Summary: The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appears to play a role in myogenesis. In adults, the transcript is localized to several tissues including brain, heart, and skeletal and smooth muscle, and a function in cytoskeletal remodeling has been described. Transcripts with expanded CUG repeats in the 3' untranslated region mediate alternative splicing of several genes and sequester RNA binding proteins and RNA transcripts that contain CAG repeats, resulting in myotonic dystrophy, an autosomal dominant neuromuscular disorder. Alternative splicing results in multiple protein coding and non-coding transcript variants. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: establishment of localization in cell, intracellular calcium ion homeostasis, muscle cell apoptotic process, nuclear envelope organization, protein phosphorylation, regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction, regulation of heart contraction, regulation of myotube differentiation, regulation of skeletal muscle contraction by calcium ion signaling, regulation of sodium ion transport, regulation of synapse structural plasticity; MF: ATP binding, kinase activity, metal ion binding, myosin phosphatase regulator activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion, nuclear membrane, nuclear outer membrane, nucleus, plasma membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways: Cardiac conduction, Ion homeostasis, Muscle contraction
UniProt: P54265
Entrez ID: 13400
|
Does Knockout of Mir467e in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mir467e
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mir467e (microRNA 467e)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100124448
|
Does Knockout of Sgpl1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Sgpl1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Sgpl1 (sphingosine phosphate lyase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Leydig cell differentiation, androgen metabolic process, apoptotic process, apoptotic signaling pathway, carboxylic acid metabolic process, ceramide metabolic process, estrogen metabolic process, face morphogenesis, fatty acid metabolic process, female gonad development, fibroblast migration, hemopoiesis, kidney development, lipid metabolic process, luteinization, platelet-derived growth factor receptor signaling pathway, post-embryonic development, regulation of multicellular organism growth, roof of mouth development, skeletal system morphogenesis, spermatogenesis, sphingolipid catabolic process, sphingolipid metabolic process, vasculogenesis; MF: carbon-carbon lyase activity, lyase activity, pyridoxal phosphate binding, sphinganine-1-phosphate aldolase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Metabolism, Metabolism of lipids, Sphingolipid catabolism, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), sphingosine and sphingosine-1-phosphate metabolism
UniProt: Q8R0X7
Entrez ID: 20397
|
Does Knockout of Ppm1h in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Ppm1h
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ppm1h (protein phosphatase 1H (PP2C domain containing))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity, hydrolase activity, identical protein binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: cytoplasm, glutamatergic synapse, mitochondrion, nucleoplasm, nucleus, synapse
Pathways:
UniProt: Q3UYC0
Entrez ID: 319468
|
Does Knockout of Mex3b in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Mex3b
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Mex3b (mex3 RNA binding family member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of localization in cell, positive regulation of cell-cell adhesion, positive regulation of phagocytosis, protein localization to cell cortex; MF: GTPase activating protein binding, RNA binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: P-body, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: F8WJD6
Entrez ID: 108797
|
Does Knockout of Cyp4b1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Cyp4b1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cyp4b1 (cytochrome P450, family 4, subfamily b, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biphenyl metabolic process, fatty acid metabolic process; MF: heme binding, heterocyclic compound binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Arachidonate metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, Fatty acid metabolism, Fatty acids, Metabolism, Metabolism of lipids, Miscellaneous substrates, Phase I - Functionalization of compounds, Synthesis of Leukotrienes (LT) and Eoxins (EX), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q64462
Entrez ID: 13120
|
Does Knockout of Slco6c1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Slco6c1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Slco6c1 (solute carrier organic anion transporter family, member 6c1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: organic anion transport, sodium-independent organic anion transport, transmembrane transport; MF: organic anion transmembrane transporter activity, sodium-independent organic anion transmembrane transporter activity; CC: CatSper complex, basolateral plasma membrane, cell projection, cilium, membrane, motile cilium, plasma membrane
Pathways:
UniProt: Q8C0X7
Entrez ID: 74441
|
Does Knockout of Sec61b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Sec61b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sec61b (SEC61 translocon subunit beta)
Type: protein-coding
Summary: Enables ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation; post-translational protein targeting to membrane, translocation; and retrograde protein transport, ER to cytosol. Located in endoplasmic reticulum quality control compartment. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ERAD pathway, SRP-dependent cotranslational protein targeting to membrane, translocation, intracellular protein transport, post-translational protein targeting to membrane, translocation, protein transport, retrograde protein transport, ER to cytosol; MF: epidermal growth factor binding, guanyl-nucleotide exchange factor activity, protein binding, ribosome binding; CC: Sec61 translocon complex, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, membrane
Pathways: Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, Phagosome - Mus musculus (mouse), Protein export - Mus musculus (mouse), Protein localization, Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q9CQS8
Entrez ID: 66212
|
Does Knockout of Ube2g2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,278
|
Knockout
|
Ube2g2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ube2g2 (ubiquitin-conjugating enzyme E2G 2)
Type: protein-coding
Summary: Enables identical protein binding activity and ubiquitin conjugating enzyme activity. Acts upstream of or within ERAD pathway. Located in cytosol and endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human UBE2G2 (ubiquitin conjugating enzyme E2 G2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ERAD pathway, cellular response to interferon-beta, negative regulation of retrograde protein transport, ER to cytosol, protein K48-linked ubiquitination, protein catabolic process, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, identical protein binding, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity; CC: cytosol, endoplasmic reticulum, lipid droplet
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P60605
Entrez ID: 22213
|
Does Knockout of Kat7 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Kat7
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Kat7 (K(lysine) acetyltransferase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin disassembly, T cell differentiation, chromatin organization, internal peptidyl-lysine acetylation, natural killer cell differentiation, positive regulation of DNA replication, positive regulation of DNA-templated transcription, elongation, positive regulation of erythrocyte differentiation, positive regulation of hematopoietic stem cell proliferation, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein localization to nucleus, positive regulation of transcription by RNA polymerase II, regulation of DNA biosynthetic process, regulation of DNA replication, regulation of DNA-templated DNA replication initiation, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell growth, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, response to actinomycin D, response to anisomycin, response to dithiothreitol, response to hydroxyurea, response to sorbitol, stress-activated protein kinase signaling cascade, transcription initiation-coupled chromatin remodeling; MF: DNA replication origin binding, acyltransferase activity, chromatin binding, histone H3 acetyltransferase activity, histone H3K14 acetyltransferase activity, histone H3K23 acetyltransferase activity, histone H3K4 acetyltransferase activity, histone H4 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone acetyltransferase activity, metal ion binding, protein-lysine-acetyltransferase activity, transcription coregulator activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytosol, histone H3-K14 acetyltransferase complex, histone acetyltransferase complex, nucleolus, nucleoplasm, nucleus, site of DNA damage
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q5SVQ0
Entrez ID: 217127
|
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