prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Mbtps1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Mbtps1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mbtps1 (membrane-bound transcription factor peptidase, site 1)
Type: protein-coding
Summary: Enables serine-type endopeptidase activity. Involved in membrane protein intracellular domain proteolysis and mitotic G2 DNA damage checkpoint signaling. Acts upstream of or within lipid metabolic process. Located in Golgi stack. Is expressed in several structures, including ectoplacental cone; genitourinary system; liver; neural tube; and somite. Used to study idiopathic scoliosis. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kondo-Fu type. Orthologous to human MBTPS1 (membrane bound transcription factor peptidase, site 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: NLS-bearing protein import into nucleus, cholesterol metabolic process, lipid metabolic process, lysosome organization, membrane protein intracellular domain proteolysis, mitotic G2 DNA damage checkpoint signaling, positive regulation of cholesterol biosynthetic process, protein import into nucleus, protein maturation, protein processing, proteolysis, regulation of vesicle-mediated transport, steroid metabolic process; MF: endopeptidase activity, hydrolase activity, metalloendopeptidase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: Golgi apparatus, Golgi membrane, Golgi stack, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: ATF6 (ATF6-alpha) activates chaperones, ATF6B (ATF6-beta) activates chaperones, CREB3 factors activate genes, Cellular responses to stimuli, Cellular responses to stress, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, Post-translational protein modification, Post-translational protein phosphorylation, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Regulation of cholesterol biosynthesis by SREBP (SREBF), Unfolded Protein Response (UPR)
UniProt: Q9WTZ2
Entrez ID: 56453
|
Does Knockout of Ppy in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Ppy
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ppy (pancreatic polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: feeding behavior, neuropeptide signaling pathway; MF: G protein-coupled receptor binding, hormone activity, neuropeptide Y receptor binding, neuropeptide hormone activity; CC: cytoplasm, extracellular region, extracellular space
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: P10601
Entrez ID: 19064
|
Does Knockout of Rac1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Rac1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rac1 (Rac family small GTPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rac protein signal transduction, Wnt signaling pathway, planar cell polarity pathway, actin cytoskeleton organization, actin filament organization, actin filament polymerization, anatomical structure arrangement, angiotensin-activated signaling pathway involved in heart process, auditory receptor cell morphogenesis, axon guidance, bone resorption, cell adhesion, cell chemotaxis, cell migration, cell motility, cell projection assembly, cell-cell junction organization, cellular response to mechanical stimulus, cerebral cortex GABAergic interneuron development, cerebral cortex radially oriented cell migration, chemotaxis, cochlea morphogenesis, cortical cytoskeleton organization, cytoskeleton organization, dendrite development, dendrite morphogenesis, dopaminergic neuron differentiation, embryonic olfactory bulb interneuron precursor migration, endocytosis, engulfment of apoptotic cell, enzyme-linked receptor protein signaling pathway, epithelial cell morphogenesis, erythrocyte enucleation, establishment or maintenance of cell polarity, forebrain development, heart process, hepatocyte growth factor receptor signaling pathway, homeostasis of number of cells, homeostasis of number of cells within a tissue, hyperosmotic response, interneuron migration, lamellipodium assembly, localization within membrane, mast cell chemotaxis, midbrain dopaminergic neuron differentiation, motor neuron axon guidance, negative regulation of fibroblast migration, negative regulation of interleukin-23 production, neuron migration, neuron projection morphogenesis, non-canonical Wnt signaling pathway, phagocytosis, engulfment, positive regulation of DNA replication, positive regulation of actin filament polymerization, positive regulation of bicellular tight junction assembly, positive regulation of cell-substrate adhesion, positive regulation of dendritic spine development, positive regulation of endothelial cell migration, positive regulation of filopodium assembly, positive regulation of focal adhesion assembly, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of lamellipodium assembly, positive regulation of microtubule polymerization, positive regulation of neutrophil chemotaxis, positive regulation of ovarian follicle development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein phosphorylation, positive regulation of ruffle assembly, positive regulation of skeletal muscle acetylcholine-gated channel clustering, positive regulation of stress fiber assembly, positive regulation of substrate adhesion-dependent cell spreading, postsynaptic actin cytoskeleton organization, protein localization to plasma membrane, quinolinate biosynthetic process, regulation of ERK5 cascade, regulation of actin cytoskeleton organization, regulation of cell adhesion involved in heart morphogenesis, regulation of cell migration, regulation of cell morphogenesis, regulation of cell shape, regulation of fibroblast migration, regulation of lamellipodium assembly, regulation of neuron maturation, regulation of neuron migration, regulation of neuronal synaptic plasticity, regulation of neutrophil migration, regulation of nitric oxide biosynthetic process, regulation of postsynapse assembly, regulation of receptor signaling pathway via JAK-STAT, regulation of respiratory burst, regulation of stress fiber assembly, regulation of synaptic vesicle endocytosis, response to lipopolysaccharide, ruffle assembly, semaphorin-plexin signaling pathway, small GTPase-mediated signal transduction, sphingosine-1-phosphate receptor signaling pathway, substrate adhesion-dependent cell spreading, superoxide anion generation, synaptic transmission, GABAergic; MF: ATPase binding, G protein activity, GTP binding, GTP-dependent protein binding, GTPase activity, Rho GDP-dissociation inhibitor binding, enzyme binding, histone deacetylase binding, hydrolase activity, nucleotide binding, protein binding, protein kinase binding, protein-containing complex binding, small GTPase binding, thioesterase binding; CC: GABA-ergic synapse, Golgi membrane, NADPH oxidase complex, actin filament, cell cortex, cell projection, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic vesicle, cytoskeleton, cytosol, dendrite, early endosome membrane, glutamatergic synapse, kinocilium, lamellipodium, melanosome, membrane, nucleus, pericentriolar material, phagocytic cup, plasma membrane, postsynapse, postsynaptic membrane, presynaptic membrane, recycling endosome membrane, ruffle membrane, synapse, synaptic vesicle membrane, trans-Golgi network
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Activated NTRK2 signals through FYN, Adaptive Immune System, Adherens junction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), Azathioprine ADME, B cell receptor signaling pathway - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Beta-catenin independent WNT signaling, CD28 dependent Vav1 pathway, Cell death signalling via NRAGE, NRIF and NADE, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Co-stimulation by CD28, Colorectal cancer - Mus musculus (mouse), DAP12 interactions, DAP12 signaling, DCC mediated attractive signaling, Death Receptor Signaling, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), Drug ADME, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHB-mediated forward signaling, Ephrin signaling, Epstein-Barr virus infection - Mus musculus (mouse), FCERI mediated MAPK activation, Factors involved in megakaryocyte development and platelet production, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), GPVI-mediated activation cascade, Hemostasis, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Intracellular signaling by second messengers, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), L1CAM interactions, Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK6/MAPK4 signaling, MET activates RAP1 and RAC1, MET promotes cell motility, NRAGE signals death through JNK, NTRK2 activates RAC1, Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Nervous system development, Netrin-1 signaling, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Neutrophil extracellular trap formation - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PCP/CE pathway, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, Pancreatic cancer - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Platelet activation, signaling and aggregation, Prion disease - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases Activate NADPH Oxidases, RHO GTPases Activate WASPs and WAVEs, RHO GTPases activate CIT, RHO GTPases activate IQGAPs, RHO GTPases activate KTN1, RHO GTPases activate PAKs, RHO GTPases activate PKNs, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Renal cell carcinoma - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Sema3A PAK dependent Axon repulsion, Sema4D in semaphorin signaling, Sema4D mediated inhibition of cell attachment and migration, Semaphorin interactions, Signal Transduction, Signal transduction by L1, Signaling by MET, Signaling by NTRK2 (TRKB), Signaling by NTRKs, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by VEGF, Signaling by WNT, Sphingolipid signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), p75 NTR receptor-mediated signalling
UniProt: P63001
Entrez ID: 19353
|
Does Knockout of Serinc2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Serinc2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Serinc2 (serine incorporator 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phosphatidylserine metabolic process, plasma membrane phospholipid scrambling; MF: acetyltransferase activator activity, phospholipid scramblase activity; CC: membrane, plasma membrane
Pathways: Metabolism, Metabolism of amino acids and derivatives, Serine metabolism
UniProt: Q8K0E7
Entrez ID: 230779
|
Does Knockout of Sla2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Sla2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sla2 (Src-like-adaptor 2)
Type: protein-coding
Summary: Predicted to enable signaling adaptor activity. Acts upstream of or within T cell activation. Located in late endosome and plasma membrane. Is expressed in thymus primordium. Orthologous to human SLA2 (Src like adaptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: T cell activation, adaptive immune response, immune system process, negative regulation of T cell receptor signaling pathway, negative regulation of calcium-mediated signaling, negative regulation of transcription by RNA polymerase II; MF: protein binding, signaling adaptor activity; CC: Golgi apparatus, cytoplasm, cytoplasmic vesicle, endomembrane system, endosome, late endosome, membrane, nucleoplasm, plasma membrane
Pathways: Cytokine Signaling in Immune system, FLT3 Signaling, Immune System, Negative regulation of FLT3
UniProt: Q8R4L0
Entrez ID: 77799
|
Does Knockout of Ndufaf6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Ndufaf6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ndufaf6 (NADH:ubiquinone oxidoreductase complex assembly factor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly; CC: cytoplasm, membrane, mitochondrial inner membrane, mitochondrion, nucleus
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: A2AIL4
Entrez ID: 76947
|
Does Knockout of Pmf1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Pmf1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pmf1 (polyamine-modulated factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, positive regulation of DNA-templated transcription; MF: leucine zipper domain binding, protein binding, transcription coactivator activity; CC: Golgi apparatus, MIS12/MIND type complex, chromosome, chromosome, centromeric region, kinetochore, nucleoplasm, nucleus, outer kinetochore, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CPV5
Entrez ID: 67037
|
Does Knockout of Ubl5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Ubl5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ubl5 (ubiquitin-like 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA splicing, via spliceosome, protein modification process; CC: cytoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9EPV8
Entrez ID: 66177
|
Does Knockout of Mon2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Mon2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mon2 (MON2 homolog, regulator of endosome to Golgi trafficking)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to endosome transport, protein transport; CC: cytosol, early endosome membrane, endosome, membrane
Pathways:
UniProt: Q80TL7
Entrez ID: 67074
|
Does Knockout of Prrc1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Prrc1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Prrc1 (proline-rich coiled-coil 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, protein kinase A regulatory subunit binding; CC: Golgi apparatus, cytoplasm
Pathways:
UniProt: Q3UPH1
Entrez ID: 73137
|
Does Knockout of Tango2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Tango2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tango2 (transport and golgi organization 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, protein secretion; CC: Golgi apparatus, cytoplasm, cytosol, mitochondrion
Pathways:
UniProt: P54797
Entrez ID: 27883
|
Does Knockout of Emc2 in Microglial Cell Line causally result in protein/peptide distribution?
| 1
| 1,585
|
Knockout
|
Emc2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Emc2 (ER membrane protein complex subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein insertion into ER membrane by stop-transfer membrane-anchor sequence, tail-anchored membrane protein insertion into ER membrane; MF: membrane insertase activity; CC: EMC complex, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, extrinsic component of endoplasmic reticulum membrane, membrane, mitochondrion
Pathways:
UniProt: Q9CRD2
Entrez ID: 66736
|
Does Knockout of Upf1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Upf1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Upf1 (UPF1 RNA helicase and ATPase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, DNA repair, DNA replication, cell cycle phase transition, cellular response to interleukin-1, cellular response to lipopolysaccharide, histone mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of mRNA catabolic process, positive regulation of mRNA cis splicing, via spliceosome, positive regulation of mRNA metabolic process, random inactivation of X chromosome, regulation of gene expression, regulation of telomere maintenance, regulation of translational termination, telomere maintenance via semi-conservative replication; MF: ATP binding, ATP hydrolysis activity, DNA binding, RNA binding, RNA helicase activity, chromatin binding, double-stranded DNA helicase activity, helicase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein-containing complex binding, telomeric DNA binding, zinc ion binding; CC: P-body, chromatin, chromosome, telomeric region, cytoplasm, cytosol, exon-exon junction complex, nucleoplasm, nucleus, perinuclear region of cytoplasm, supraspliceosomal complex
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9EPU0
Entrez ID: 19704
|
Does Knockout of Zfp563 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Zfp563
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp563 (zinc finger protein 563)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: B8JK01, B8JJZ9, F6R6Y7
Entrez ID: 240068
|
Does Knockout of Galnt10 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Galnt10
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Galnt10 (polypeptide N-acetylgalactosaminyltransferase 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein O-linked glycosylation, protein O-linked glycosylation via N-acetyl-galactosamine, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism of proteins, Mucin type O-glycan biosynthesis - Mus musculus (mouse), O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification
UniProt: Q6P9S7
Entrez ID: 171212
|
Does Knockout of Zfp955b in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Zfp955b
|
cell cycle progression
|
breast epithelium
|
Gene: Zfp955b (zinc finger protein 955B)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: L7N232, Q9CS13
Entrez ID: 100043468
|
Does Knockout of Pde6b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Pde6b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pde6b (phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detection of light stimulus, entrainment of circadian clock by photoperiod, negative regulation of cAMP/PKA signal transduction, retina development in camera-type eye, retinal cell apoptotic process, signal transduction, visual perception; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity; CC: cell projection, membrane, photoreceptor outer segment, photoreceptor outer segment membrane, plasma membrane
Pathways: Activation of the phototransduction cascade, Beta-catenin independent WNT signaling, Ca2+ pathway, Inactivation, recovery and regulation of the phototransduction cascade, Phototransduction - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by WNT, The phototransduction cascade, Visual phototransduction, cyclic GMP biosynthesis
UniProt: P23440
Entrez ID: 18587
|
Does Knockout of Sharpin in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Sharpin
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sharpin (SHANK-associated RH domain interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic nuclear changes, defense response to bacterium, epidermis development, keratinization, mitochondrion organization, negative regulation of canonical NF-kappaB signal transduction, negative regulation of inflammatory response, positive regulation of canonical NF-kappaB signal transduction, proteasome-mediated ubiquitin-dependent protein catabolic process, protein linear polyubiquitination, protein ubiquitination, regulation of CD40 signaling pathway, regulation of tumor necrosis factor-mediated signaling pathway, tumor necrosis factor-mediated signaling pathway; MF: identical protein binding, metal ion binding, polyubiquitin modification-dependent protein binding, protein binding, protein-containing complex binding, protein-macromolecule adaptor activity, ubiquitin binding, ubiquitin-protein transferase activity, zinc ion binding; CC: LUBAC complex, cytoplasm, cytosol, dendrite, glutamatergic synapse, postsynaptic density, synapse
Pathways: NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse)
UniProt: Q91WA6
Entrez ID: 106025
|
Does Knockout of Syt3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Syt3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Syt3 (synaptotagmin III)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, chemical synaptic transmission, exocytosis, positive regulation of dendrite extension, positive regulation of vesicle fusion, regulation of calcium ion-dependent exocytosis, regulation of postsynaptic membrane neurotransmitter receptor levels, response to calcium ion, vesicle-mediated transport; MF: SNARE binding, calcium ion sensor activity, calcium-dependent phospholipid binding, clathrin binding, identical protein binding, metal ion binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylserine binding, phospholipid binding, protein binding, protein heterodimerization activity, protein homodimerization activity, syntaxin binding; CC: cytoplasmic vesicle, endosome, exocytic vesicle, membrane, plasma membrane, postsynapse, synaptic membrane, transport vesicle membrane
Pathways:
UniProt: O35681
Entrez ID: 20981
|
Does Knockout of D630003M21Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
D630003M21Rik
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: D630003M21Rik (RIKEN cDNA D630003M21 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BWG4
Entrez ID: 228846
|
Does Knockout of Ehbp1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Ehbp1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ehbp1 (EH domain binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytosis, protein transport; CC: cytoplasm, cytosol, endosome, membrane, nucleoplasm, plasma membrane
Pathways:
UniProt: Q69ZW3
Entrez ID: 216565
|
Does Knockout of Adgrb2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Adgrb2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Adgrb2 (adhesion G protein-coupled receptor B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcineurin-NFAT signaling cascade, cell surface receptor signaling pathway, negative regulation of angiogenesis, peripheral nervous system development, positive regulation of synapse assembly, signal transduction; MF: G protein-coupled receptor activity, protein binding, transmembrane signaling receptor activity; CC: extracellular region, glutamatergic synapse, membrane, plasma membrane, synapse
Pathways:
UniProt: Q8CGM1
Entrez ID: 230775
|
Does Knockout of Tomm6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Tomm6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tomm6 (translocase of outer mitochondrial membrane 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion
Pathways: Autophagy, Macroautophagy, Mitophagy, PINK1-PRKN Mediated Mitophagy, Selective autophagy
UniProt: Q9CQN3
Entrez ID: 66119
|
Does Knockout of Hmgb2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Hmgb2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hmgb2 (high mobility group box 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA recombination, DNA topological change, cell chemotaxis, cellular response to lipopolysaccharide, chemotaxis, chromatin remodeling, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, immune system process, inflammatory response, inflammatory response to antigenic stimulus, innate immune response, male gonad development, negative regulation of DNA-templated transcription, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, positive chemotaxis, positive regulation of DNA-templated transcription, positive regulation of endothelial cell proliferation, positive regulation of erythrocyte differentiation, positive regulation of gene expression, positive regulation of innate immune response, positive regulation of interferon-beta production, positive regulation of megakaryocyte differentiation, positive regulation of transcription by RNA polymerase II, regulation of neurogenesis, regulation of stem cell proliferation, regulation of transcription by RNA polymerase II, response to lipopolysaccharide, response to steroid hormone, spermatid nucleus differentiation, spermatogenesis; MF: DNA binding, DNA binding, bending, DNA-binding transcription factor binding, RAGE receptor binding, chemoattractant activity, cis-regulatory region sequence-specific DNA binding, damaged DNA binding, double-stranded DNA binding, lipid binding, non-sequence-specific DNA binding, bending, protein binding, protein domain specific binding, supercoiled DNA binding, transcription cis-regulatory region binding, transcription coactivator activity, transcription factor binding; CC: chromatin, chromosome, condensed chromosome, cytoplasm, extracellular region, extracellular space, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways:
UniProt: P30681
Entrez ID: 97165
|
Does Knockout of Guk1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Guk1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Guk1 (guanylate kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GDP biosynthetic process, GDP metabolic process, GDP-mannose metabolic process, GMP metabolic process, dATP metabolic process, dGDP biosynthetic process, dGMP metabolic process, glycoprotein transport, purine nucleotide metabolic process, xenobiotic metabolic process; MF: ATP binding, GMP kinase activity, kinase activity, nucleotide binding, transferase activity; CC: cytoplasm, cytosol, mitochondrion, photoreceptor inner segment
Pathways: Azathioprine ADME, Drug ADME, Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Mus musculus (mouse), purine and pyrimidine metabolism
UniProt: Q64520
Entrez ID: 14923
|
Does Knockout of Eefsec in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Eefsec
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eefsec (eukaryotic elongation factor, selenocysteine-tRNA-specific)
Type: protein-coding
Summary: Enables several functions, including GTP binding activity; RNA binding activity; and translation elongation factor activity. Acts upstream of or within selenocysteine incorporation. Located in mitochondrion. Part of ribonucleoprotein complex. Orthologous to human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: selenocysteine incorporation, translation; MF: GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding, ribonucleoprotein complex binding, selenocysteine insertion sequence binding, tRNA binding, translation elongation factor activity; CC: cytoplasm, cytosol, mitochondrion, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q9JHW4
Entrez ID: 65967
|
Does Knockout of Timmdc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Timmdc1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Timmdc1 (translocase of inner mitochondrial membrane domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, mitochondrial respiratory chain complex I assembly; CC: membrane, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport
UniProt: Q8BUY5
Entrez ID: 76916
|
Does Knockout of Rassf4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Rassf4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rassf4 (Ras association (RalGDS/AF-6) domain family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: signal transduction
Pathways: Hippo signaling pathway - multiple species - Mus musculus (mouse)
UniProt: Q8CB96
Entrez ID: 213391
|
Does Knockout of Cfap69 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Cfap69
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cfap69 (cilia and flagella associated protein 69)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, flagellated sperm motility, olfactory behavior, positive regulation of fertilization, positive regulation of flagellated sperm motility, response to odorant, sensory perception of smell, sperm axoneme assembly, spermatogenesis; MF: molecular_function, protein binding; CC: axonemal central pair projection, cell projection, cilium, cytoplasm, motile cilium, non-motile cilium, sperm midpiece
Pathways:
UniProt: Q8BH53
Entrez ID: 207686
|
Does Knockout of Mrpl12 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Mrpl12
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mrpl12 (mitochondrial ribosomal protein L12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial transcription, mitochondrial translation, positive regulation of DNA-templated transcription, translation; MF: mRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial matrix, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9DB15
Entrez ID: 56282
|
Does Knockout of Vmn1r148 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Vmn1r148
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vmn1r148 (vomeronasal 1 receptor 148)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q9EPS5
Entrez ID: 81011
|
Does Knockout of Akr1cl in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 1
| 1,522
|
Knockout
|
Akr1cl
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Akr1cl (aldo-keto reductase family 1, member C-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: daunorubicin metabolic process, doxorubicin metabolic process, progesterone metabolic process, prostaglandin metabolic process; MF: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity, Delta4-3-oxosteroid 5beta-reductase activity, alcohol dehydrogenase (NADP+) activity, aldose reductase (NADPH) activity, all-trans-retinol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, bile acid binding, carboxylic acid binding, chlordecone reductase activity, geranylgeranyl reductase activity, ketoreductase activity, ketosteroid monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, prostaglandin D2 11-ketoreductase activity, prostaglandin H2 endoperoxidase reductase activity, retinal dehydrogenase (NAD+) activity, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: G3XA14, Q3UXL1, Q9D5U2, E0CYR9
Entrez ID: 70861
|
Does Knockout of Ces5a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Ces5a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ces5a (carboxylesterase 5A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carboxylesterase activity, carboxylic ester hydrolase activity, hydrolase activity
Pathways:
UniProt: Q6AW46
Entrez ID: 67935
|
Does Knockout of Btbd9 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Btbd9
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Btbd9 (BTB domain containing 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult locomotory behavior, circadian behavior, circadian sleep/wake cycle, non-REM sleep, long-term memory, modulation of chemical synaptic transmission, multicellular organismal-level iron ion homeostasis, regulation of synaptic vesicle endocytosis, sensory perception of temperature stimulus, serotonin metabolic process; CC: cytoplasm, glutamatergic synapse
Pathways:
UniProt: Q8C726
Entrez ID: 224671
|
Does Knockout of Scgb1c1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Scgb1c1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Scgb1c1 (secretoglobin, family 1C, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: G5E8B5
Entrez ID: 338417
|
Does Knockout of Fen1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Fen1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fen1 (flap structure specific endonuclease 1)
Type: protein-coding
Summary: Enables DNA binding activity; metal ion binding activity; and nuclease activity. Acts upstream of or within DNA repair and DNA replication. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human FEN1 (flap structure-specific endonuclease 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication, removal of RNA primer, base-excision repair, memory, positive regulation of sister chromatid cohesion; MF: 5'-3' exonuclease activity, 5'-flap endonuclease activity, DNA binding, RNA-DNA hybrid ribonuclease activity, catalytic activity, endonuclease activity, exonuclease activity, flap endonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds, magnesium ion binding, manganese ion binding, metal ion binding, nuclease activity; CC: chromosome, telomeric region, mitochondrion, nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways: Base excision repair - Mus musculus (mouse), DNA replication - Mus musculus (mouse), Non-homologous end-joining - Mus musculus (mouse)
UniProt: Q8C952, Q91Z50
Entrez ID: 14156
|
Does Knockout of Prex2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Prex2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Prex2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity; guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase inhibitor activity. Acts upstream of or within adult locomotory behavior; dendrite morphogenesis; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in plasma membrane. Is expressed in brain ventricular layer and gut. Human ortholog(s) of this gene implicated in Klatskin's tumor and cholangiocarcinoma. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adult locomotory behavior, dendrite morphogenesis, intracellular signal transduction, negative regulation of TOR signaling, phosphatidylinositol 3-kinase/protein kinase B signal transduction, signal transduction; MF: GTPase activator activity, guanyl-nucleotide exchange factor activity, protein serine/threonine kinase inhibitor activity; CC: plasma membrane
Pathways: CDC42 GTPase cycle, Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Regulation of PTEN stability and activity, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q3LAC4
Entrez ID: 109294
|
Does Knockout of Atp6v1g1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Atp6v1g1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Atp6v1g1 (ATPase, H+ transporting, lysosomal V1 subunit G1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to increased oxygen levels, intracellular iron ion homeostasis, monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: ATP hydrolysis activity, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: ATPase complex, apical plasma membrane, cytosol, extrinsic component of synaptic vesicle membrane, lysosomal membrane, membrane, plasma membrane, presynapse, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9CR51
Entrez ID: 66290
|
Does Knockout of Hirip3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Hirip3
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Hirip3 (HIRA interacting protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, chromatin organization; MF: H2A-H2B histone complex chaperone activity, molecular_function; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8BLH7
Entrez ID: 233876
|
Does Knockout of Mars2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Mars2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mars2 (methionine-tRNA synthetase 2 (mitochondrial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methionyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, methionine-tRNA ligase activity, nucleotide binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), Selenocompound metabolism - Mus musculus (mouse), tRNA charging pathway
UniProt: Q499X9
Entrez ID: 212679
|
Does Knockout of Fap in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Fap
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Fap (fibroblast activation protein)
Type: protein-coding
Summary: This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: angiogenesis, apoptotic process, cell adhesion, endothelial cell migration, melanocyte apoptotic process, melanocyte proliferation, negative regulation of cell proliferation involved in contact inhibition, negative regulation of extracellular matrix disassembly, negative regulation of extracellular matrix organization, positive regulation of execution phase of apoptosis, proteolysis, proteolysis involved in protein catabolic process, regulation of cell cycle, regulation of collagen catabolic process; MF: dipeptidyl-peptidase activity, endopeptidase activity, hydrolase activity, identical protein binding, integrin binding, peptidase activity, protease binding, protein homodimerization activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: anchoring junction, apical part of cell, basal part of cell, cell projection, cell surface, extracellular region, extracellular space, lamellipodium, lamellipodium membrane, membrane, peptidase complex, plasma membrane, ruffle membrane
Pathways:
UniProt: P97321
Entrez ID: 14089
|
Does Knockout of Cops8 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Cops8
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Cops8 (COP9 signalosome subunit 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COP9 signalosome assembly, negative regulation of cell population proliferation, protein deneddylation; CC: COP9 signalosome, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q8VBV7
Entrez ID: 108679
|
Does Knockout of Ndufs3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Ndufs3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ndufs3 (NADH:ubiquinone oxidoreductase core subunit S3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport, reactive oxygen species metabolic process; MF: NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, myelin sheath, nuclear body, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RHO GTPase cycle, RHOG GTPase cycle, Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9DCT2
Entrez ID: 68349
|
Does Knockout of Ankrd52 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ankrd52
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ankrd52 (ankyrin repeat domain 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BTI7
Entrez ID: 237615
|
Does Knockout of Ywhae in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Ywhae
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ywhae (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, MAPK cascade, cellular response to heat, cerebral cortex development, cytoplasmic pattern recognition receptor signaling pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of protein localization, hippo signaling, hippocampus development, intracellular potassium ion homeostasis, intracellular protein localization, negative regulation of calcium ion export across plasma membrane, negative regulation of toll-like receptor signaling pathway, neuron migration, positive regulation of hippo signaling, positive regulation of protein export from nucleus, positive regulation of toll-like receptor signaling pathway, protein K11-linked ubiquitination, protein localization to endoplasmic reticulum, protein localization to nucleus, protein targeting, regulation of cytosolic calcium ion concentration, regulation of membrane repolarization, regulation of mitotic cell cycle, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of potassium ion transmembrane transport, signal transduction, toll-like receptor 4 signaling pathway; MF: calcium channel inhibitor activity, calcium channel regulator activity, enzyme binding, enzyme inhibitor activity, histone deacetylase binding, identical protein binding, phosphoprotein binding, phosphoserine residue binding, potassium channel regulator activity, protein binding, protein domain specific binding, protein heterodimerization activity, protein phosphatase binding, protein phosphatase inhibitor activity, protein sequestering activity, protein-containing complex binding, scaffold protein binding, signaling adaptor activity, transmembrane transporter binding, ubiquitin protein ligase binding; CC: axon, central region of growth cone, cytoplasm, cytosol, endoplasmic reticulum, glutamatergic synapse, kinesin complex, melanosome, mitochondrion, nucleus, plasma membrane, synapse
Pathways: AURKA Activation by TPX2, Activation of BAD and translocation to mitochondria , Activation of BH3-only proteins, Anchoring of the basal body to the plasma membrane, Apoptosis, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cell death signalling via NRAGE, NRIF and NADE, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Cilium Assembly, Death Receptor Signaling, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, HSF1 activation, Hepatitis C - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Intrinsic Pathway for Apoptosis, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Membrane Trafficking, Mitotic G2-G2/M phases, Mitotic Prometaphase, NADE modulates death signalling, NOD-like receptor signaling pathway - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Organelle biogenesis and maintenance, PI3K-Akt signaling pathway - Mus musculus (mouse), Programmed Cell Death, RAB GEFs exchange GTP for GDP on RABs, RHO GTPase Effectors, RHO GTPases activate PKNs, RNA Polymerase II Transcription, Rab regulation of trafficking, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of HSF1-mediated heat shock response, Regulation of PLK1 Activity at G2/M Transition, Signal Transduction, Signaling by Hippo, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, Vesicle-mediated transport, Viral carcinogenesis - Mus musculus (mouse), p75 NTR receptor-mediated signalling
UniProt: P62259
Entrez ID: 22627
|
Does Knockout of Vmn1r223 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Vmn1r223
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r223 (vomeronasal 1 receptor 223)
Type: protein-coding
Summary: vomeronasal 1 receptor 223
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q5SSA0
Entrez ID: 100036518
|
Does Knockout of Hibadh in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Hibadh
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hibadh (3-hydroxyisobutyrate dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-valine catabolic process, branched-chain amino acid catabolic process; MF: 3-hydroxyisobutyrate dehydrogenase activity, NAD binding, NADP binding, oxidoreductase activity; CC: mitochondrion
Pathways: Branched-chain amino acid catabolism, Metabolism, Metabolism of amino acids and derivatives, Valine, leucine and isoleucine degradation - Mus musculus (mouse), valine degradation, valine degradation I
UniProt: Q99L13
Entrez ID: 58875
|
Does Knockout of Wfdc6b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Wfdc6b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Wfdc6b (WAP four-disulfide core domain 6B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: F6ULY1
Entrez ID: 433502
|
Does Knockout of Ncapg2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Ncapg2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ncapg2 (non-SMC condensin II complex, subunit G2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, chromatin organization, chromosome condensation, erythrocyte differentiation, inner cell mass cell proliferation, mitotic sister chromatid segregation, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation, transcription by RNA polymerase II; MF: bHLH transcription factor binding, histone H4K20me1 reader activity, protein binding; CC: condensed nuclear chromosome, condensin complex, nuclear lumen, nuclear speck, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Condensation of Prophase Chromosomes, M Phase, Mitotic Prophase
UniProt: Q6DFV1
Entrez ID: 76044
|
Does Knockout of Tifa in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Tifa
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tifa (TRAF-interacting protein with forkhead-associated domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic pattern recognition receptor signaling pathway, immune system process, innate immune response, positive regulation of canonical NF-kappaB signal transduction, protein homooligomerization, tumor necrosis factor-mediated signaling pathway; CC: cytoplasm
Pathways: Alpha-protein kinase 1 signaling pathway, Cytokine Signaling in Immune system, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q793I8
Entrez ID: 211550
|
Does Knockout of Rbms3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Rbms3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rbms3 (RNA binding motif, single stranded interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to tumor cell, negative regulation of canonical Wnt signaling pathway, negative regulation of gene expression, positive regulation of gene expression, positive regulation of translation; MF: RNA binding, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, nucleic acid binding, poly(A) binding, poly(U) RNA binding; CC: cytoplasm, cytosol, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q8BWL5
Entrez ID: 207181
|
Does Knockout of Cops7b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Cops7b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cops7b (COP9 signalosome subunit 7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COP9 signalosome assembly, protein deneddylation; CC: COP9 signalosome, cytoplasm, nucleoplasm, nucleus
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q8BV13
Entrez ID: 26895
|
Does Knockout of Nelfa in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Nelfa
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Nelfa (negative elongation factor complex member A, Whsc2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription elongation by RNA polymerase II, positive regulation of transcription by RNA polymerase II; MF: chromatin binding, molecular adaptor activity, protein binding; CC: NELF complex, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q8BG30
Entrez ID: 24116
|
Does Knockout of Tmem44 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Tmem44
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tmem44 (transmembrane protein 44)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: basic amino acid transmembrane transport, biological_process; MF: basic amino acid transmembrane transporter activity, molecular_function
Pathways:
UniProt: Q8C820, E9Q4M0, F7D1Q2, F6Q8S3, F6SF18
Entrez ID: 224090
|
Does Knockout of Gbp10 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Gbp10
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gbp10 (guanylate-binding protein 10)
Type: protein-coding
Summary: Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within cellular response to lipopolysaccharide and defense response to other organism. Located in cytoplasmic vesicle. Is expressed in several structures, including alimentary system; nasal cavity epithelium; submandibular gland primordium; vertebral axis musculature; and vibrissa. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cellular response to lipopolysaccharide, cellular response to type II interferon, defense response to Gram-positive bacterium, defense response to protozoan, immune system process, innate immune response; MF: GTP binding, GTPase activity, hydrolase activity; CC: cytoplasmic vesicle
Pathways:
UniProt: Q000W5
Entrez ID: 626578
|
Does Knockout of Chmp4b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Chmp4b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Chmp4b (charged multivesicular body protein 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, membrane fission, midbody abscission, mitotic cytokinesis, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein transport, regulation of autophagy, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; MF: identical protein binding, protein binding, protein homodimerization activity; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endosome, endosome membrane, glutamatergic synapse, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, membrane coat, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleus, plasma membrane, postsynaptic density, vesicle
Pathways: Autophagy, Cell Cycle, Cell Cycle, Mitotic, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Mus musculus (mouse), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, Sealing of the nuclear envelope (NE) by ESCRT-III, Vesicle-mediated transport
UniProt: Q9D8B3
Entrez ID: 75608
|
Does Knockout of Nr2f1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Nr2f1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nr2f1 (nuclear receptor subfamily 2, group F, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cerebral cortex regionalization, forebrain development, interneuron migration, intracellular receptor signaling pathway, negative regulation of neuron projection development, negative regulation of transcription by RNA polymerase II, nervous system development, neuron migration, positive regulation of miRNA transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of gene expression; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, nuclear receptor activity, retinoic acid-responsive element binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription
UniProt: Q60632
Entrez ID: 13865
|
Does Knockout of Mybbp1a in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Mybbp1a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mybbp1a (MYB binding protein (P160) 1a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to glucose starvation, chromatin remodeling, circadian regulation of gene expression, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of DNA-templated transcription, positive regulation of anoikis, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, regulation of DNA-templated transcription, regulation of G1 to G0 transition, respiratory electron transport chain, rhythmic process, ribosome biogenesis; MF: DNA binding, E-box binding, protein binding, sequence-specific DNA binding, transcription corepressor activity, zinc ion binding; CC: B-WICH complex, NLS-dependent protein nuclear import complex, cytoplasm, nucleolus, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression
UniProt: Q7TPV4
Entrez ID: 18432
|
Does Knockout of Wars2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Wars2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Wars2 (tryptophanyl tRNA synthetase 2 (mitochondrial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial tryptophanyl-tRNA aminoacylation, positive regulation of angiogenesis, tRNA aminoacylation for protein translation, translation, tryptophanyl-tRNA aminoacylation, vasculogenesis; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, tryptophan-tRNA ligase activity; CC: mitochondrial matrix, mitochondrion, nucleoplasm, plasma membrane
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q9CYK1
Entrez ID: 70560
|
Does Knockout of Ndufv2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ndufv2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ndufv2 (NADH:ubiquinone oxidoreductase core subunit V2)
Type: protein-coding
Summary: This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The bovine ortholog of this protein has been characterized and is reported to contain an iron-sulfur cluster, which may be involved in electron transfer. In humans mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: aerobic respiration, cardiac muscle tissue development, mitochondrial electron transport, NADH to ubiquinone, nervous system development, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: 2 iron, 2 sulfur cluster binding, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, myelin sheath, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9D6J6
Entrez ID: 72900
|
Does Knockout of Pax2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Pax2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pax2 (paired box 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain morphogenesis, branching involved in ureteric bud morphogenesis, camera-type eye development, cell differentiation, cell fate determination, cellular response to glucose stimulus, cellular response to mechanical stimulus, cellular response to retinoic acid, central nervous system development, cochlea development, cochlea morphogenesis, dopaminergic neuron differentiation, embryonic organ morphogenesis, glial cell differentiation, inner ear morphogenesis, kidney development, mesenchymal to epithelial transition, mesenchymal to epithelial transition involved in metanephros morphogenesis, mesodermal cell fate specification, mesonephric duct development, mesonephric tubule development, mesonephric tubule formation, mesonephros development, metanephric collecting duct development, metanephric distal convoluted tubule development, metanephric epithelium development, metanephric mesenchymal cell differentiation, metanephric mesenchyme development, metanephric nephron tubule formation, metanephros development, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of apoptotic process involved in metanephric collecting duct development, negative regulation of apoptotic process involved in metanephric nephron tubule development, negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis, negative regulation of mesenchymal cell apoptotic process involved in metanephros development, negative regulation of programmed cell death, negative regulation of reactive oxygen species metabolic process, negative regulation of transcription by RNA polymerase II, nephric duct formation, nervous system development, neural tube closure, optic chiasma development, optic cup morphogenesis involved in camera-type eye development, optic nerve development, optic nerve morphogenesis, optic nerve structural organization, pancreas development, paramesonephric duct development, positive regulation of DNA-templated transcription, positive regulation of branching involved in ureteric bud morphogenesis, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, positive regulation of metanephric DCT cell differentiation, positive regulation of metanephric glomerulus development, positive regulation of optic nerve formation, positive regulation of transcription by RNA polymerase II, pronephric field specification, pronephros development, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of metanephric nephron tubule epithelial cell differentiation, regulation of metanephros size, regulation of programmed cell death, regulation of transcription by RNA polymerase II, retinal pigment epithelium development, sensory organ development, stem cell differentiation, system development, tissue development, ureter development, ureter maturation, ureter morphogenesis, ureteric bud development, urogenital system development, vestibulocochlear nerve formation; MF: C2H2 zinc finger domain binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: centriolar satellite, microtubule organizing center, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, transcription regulator complex
Pathways:
UniProt: P32114
Entrez ID: 18504
|
Does Knockout of Med31 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Med31
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Med31 (mediator complex subunit 31)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, limb development, negative regulation of fibroblast proliferation, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: protein binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways:
UniProt: Q9CXU1
Entrez ID: 67279
|
Does Knockout of P2ry4 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
P2ry4
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: P2ry4 (pyrimidinergic receptor P2Y, G-protein coupled, 4)
Type: protein-coding
Summary: Enables G protein-coupled UTP receptor activity. Acts upstream of or within cellular response to prostaglandin E stimulus and transepithelial chloride transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be active in glutamatergic synapse and presynaptic active zone membrane. Is expressed in skeletal muscle. Orthologous to human P2RY4 (pyrimidinergic receptor P2Y4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled purinergic nucleotide receptor signaling pathway, G protein-coupled receptor signaling pathway, cellular response to prostaglandin E stimulus, regulation of presynaptic cytosolic calcium ion concentration, regulation of synaptic vesicle exocytosis, signal transduction, transepithelial chloride transport; MF: ATP binding, G protein-coupled UTP receptor activity, G protein-coupled purinergic nucleotide receptor activity, G protein-coupled receptor activity, pyrimidine nucleotide binding; CC: apical plasma membrane, basolateral plasma membrane, glutamatergic synapse, membrane, plasma membrane, presynaptic active zone membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nucleotide-like (purinergic) receptors, P2Y receptors, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse)
UniProt: Q9JJS7
Entrez ID: 57385
|
Does Knockout of Dnm1l in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Dnm1l
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dnm1l (dynamin 1-like)
Type: protein-coding
Summary: This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: calcium ion transport, cellular response to hypoxia, cellular response to lipid, endocytosis, heart contraction, intracellular distribution of mitochondria, metal ion transport, mitochondrial fission, mitochondrial fragmentation involved in apoptotic process, mitochondrial membrane fission, mitochondrion distribution, mitochondrion organization, mitocytosis, negative regulation of mitochondrial fusion, peroxisome fission, positive regulation of dendritic spine morphogenesis, positive regulation of mitochondrial fission, positive regulation of neutrophil chemotaxis, positive regulation of protein secretion, positive regulation of synaptic vesicle endocytosis, positive regulation of synaptic vesicle exocytosis, programmed cell death, protein complex oligomerization, protein localization to mitochondrion, regulation of ATP metabolic process, regulation of gene expression, regulation of mitochondrion organization, regulation of mitophagy, regulation of peroxisome organization, response to endoplasmic reticulum stress, response to flavonoid, response to hypobaric hypoxia, rhythmic process, synaptic vesicle endocytosis, synaptic vesicle recycling via endosome; MF: BH2 domain binding, GTP binding, GTP-dependent protein binding, GTPase activity, clathrin binding, hydrolase activity, identical protein binding, lipid binding, microtubule binding, nucleotide binding, protein binding, protein homodimerization activity, protein serine/threonine kinase binding, protein-containing complex binding, small GTPase binding, ubiquitin protein ligase binding; CC: Golgi apparatus, Golgi membrane, brush border, clathrin-coated pit, cytoplasm, cytoplasmic vesicle, cytosol, endomembrane system, endoplasmic reticulum, endosome, late endosome, lysosome, membrane, microtubule, microtubule cytoskeleton, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, mitochondrion-derived vesicle, perinuclear region of cytoplasm, peroxisome, plasma membrane, postsynaptic density, presynaptic endocytic zone membrane, protein-containing complex, secretory vesicle, synapse, synaptic vesicle membrane
Pathways: NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: Q8K1M6
Entrez ID: 74006
|
Does Knockout of Xrcc5 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,536
|
Knockout
|
Xrcc5
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Xrcc5 (X-ray repair complementing defective repair in Chinese hamster cells 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, activation of innate immune response, cellular hyperosmotic salinity response, cellular response to X-ray, cellular response to gamma radiation, cellular response to leukemia inhibitory factor, double-strand break repair, double-strand break repair via nonhomologous end joining, hematopoietic stem cell differentiation, hematopoietic stem cell proliferation, immune system process, innate immune response, negative regulation of DNA-templated transcription, negative regulation of t-circle formation, positive regulation of neurogenesis, protein localization to chromosome, telomeric region, recombinational repair, regulation of smooth muscle cell proliferation, ribosome biogenesis, small-subunit processome assembly, telomere maintenance, telomere maintenance via telomerase; MF: 5'-deoxyribose-5-phosphate lyase activity, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, DNA binding, DNA end binding, DNA helicase activity, RNA binding, U3 snoRNA binding, damaged DNA binding, double-stranded DNA binding, double-stranded telomeric DNA binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, protein-containing complex binding, telomeric DNA binding, transcription cis-regulatory region binding, ubiquitin protein ligase binding; CC: DNA-dependent protein kinase complex, DNA-dependent protein kinase-DNA ligase 4 complex, Ku70:Ku80 complex, chromosome, chromosome, telomeric region, cytoplasm, nonhomologous end joining complex, nucleolus, nucleoplasm, nucleus, plasma membrane, protein-DNA complex, protein-containing complex, ribonucleoprotein complex, site of DNA damage, small-subunit processome
Pathways: DNA Double-Strand Break Repair, DNA Repair, Immune System, Innate Immune System, Neutrophil degranulation, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ)
UniProt: P27641
Entrez ID: 22596
|
Does Knockout of Mettl1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mettl1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mettl1 (methyltransferase 1, tRNA methylguanosine)
Type: protein-coding
Summary: Predicted to enable internal mRNA (guanine-N7-)-methyltransferase activity and tRNA (guanine(46)-N7)-methyltransferase activity. Predicted to be involved in tRNA (guanine-N7)-methylation and tRNA stabilization. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of tRNA (m7G46) methyltransferase complex. Is expressed in articular cartilage; bone marrow; femur; long bone epiphyseal plate; and perichondrium. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: RNA (guanine-N7)-methylation, cellular response to stress, intracellular mRNA localization, mRNA transport, methylation, stress granule assembly, tRNA (guanine-N7)-methylation, tRNA methylation, tRNA modification, tRNA processing, tRNA stabilization; MF: RNA binding, internal mRNA (guanine-N7-)-methyltransferase activity, methyltransferase activity, tRNA (guanine(46)-N7)-methyltransferase activity, tRNA binding, transferase activity; CC: cytosol, nucleolus, nucleoplasm, nucleus, tRNA (m7G46) methyltransferase complex, tRNA methyltransferase complex
Pathways:
UniProt: Q9Z120
Entrez ID: 17299
|
Does Knockout of Psg17 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Psg17
|
cell cycle progression
|
breast epithelium
|
Gene: Psg17 (pregnancy specific beta-1-glycoprotein 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, female pregnancy, immune response; MF: heparan sulfate proteoglycan binding, protein binding
Pathways:
UniProt: Q62056
Entrez ID: 26437
|
Does Knockout of Dpagt1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Dpagt1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Dpagt1 (dolichyl-phosphate N-acetylglucosaminephosphotransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein glycosylation; MF: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity, UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity, glycosyltransferase activity, metal ion binding, phosphotransferase activity, for other substituted phosphate groups, protein binding, transferase activity; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, dolichyl-diphosphooligosaccharide biosynthesis
UniProt: P42867
Entrez ID: 13478
|
Does Knockout of Vars2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Vars2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Vars2 (valyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and tail. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: aminoacyl-tRNA metabolism involved in translational fidelity, tRNA aminoacylation for protein translation, translation, valyl-tRNA aminoacylation; MF: ATP binding, aminoacyl-tRNA deacylase activity, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, valine-tRNA ligase activity; CC: cytosol, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q3U2A8
Entrez ID: 68915
|
Does Knockout of Raver1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Raver1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Raver1 (ribonucleoprotein, PTB-binding 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9CW46
Entrez ID: 71766
|
Does Knockout of Polq in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Polq
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Polq (polymerase (DNA directed), theta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA-templated DNA replication, base-excision repair, double-strand break repair, double-strand break repair via alternative nonhomologous end joining, error-prone translesion synthesis, negative regulation of double-strand break repair via homologous recombination, protein homooligomerization, replication fork processing, somatic hypermutation of immunoglobulin genes; MF: 5'-deoxyribose-5-phosphate lyase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, DNA polymerase activity, DNA-directed DNA polymerase activity, catalytic activity, chromatin binding, helicase activity, hydrolase activity, identical protein binding, magnesium ion binding, metal ion binding, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, single-stranded DNA helicase activity, transferase activity; CC: Golgi apparatus, chromosome, cytosol, mitochondrial nucleoid, nucleoplasm, nucleus, site of DNA damage, site of double-strand break
Pathways: DNA Double-Strand Break Repair, DNA Repair, HDR through MMEJ (alt-NHEJ), Homology Directed Repair
UniProt: Q8CGS6
Entrez ID: 77782
|
Does Knockout of Ppp4c in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Ppp4c
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ppp4c (protein phosphatase 4, catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: double-strand break repair via homologous recombination, regulation of double-strand break repair, regulation of double-strand break repair via homologous recombination; MF: hydrolase activity, lamin binding, metal ion binding, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity, protein-containing complex binding; CC: centrosome, chromatin, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, plasma membrane, protein phosphatase 4 complex
Pathways: DNA Double-Strand Break Repair, DNA Repair, Glucagon signaling pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends
UniProt: P97470
Entrez ID: 56420
|
Does Activation of Camta1 in Mouse cell causally result in protein/peptide accumulation?
| 1
| 690
|
Activation
|
Camta1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Camta1 (calmodulin binding transcription activator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuromuscular process controlling balance, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, double-stranded DNA binding, sequence-specific DNA binding, transcription coregulator activity; CC: cytoplasm, nucleus
Pathways:
UniProt: A2A891
Entrez ID: 100072
|
Does Knockout of Hnf1b in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Hnf1b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Hnf1b (HNF1 homeobox B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, anterior/posterior pattern specification, blastocyst development, branching morphogenesis of an epithelial tube, circadian regulation of gene expression, embryonic digestive tract morphogenesis, embryonic morphogenesis, endocrine pancreas development, endoderm development, endoderm formation, endodermal cell fate specification, epithelial cell proliferation, epithelium development, formation of primary germ layer, gene expression, genitalia development, hepatoblast differentiation, hindbrain development, inner cell mass cell differentiation, insulin secretion, kidney development, kidney morphogenesis, liver development, mesonephric duct development, mesonephric duct formation, mesonephric tubule development, negative regulation of apoptotic process, negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis, negative regulation of mesenchymal cell apoptotic process involved in metanephros development, negative regulation of transcription by RNA polymerase II, nephric duct development, nephric duct formation, pancreas development, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, pronephric nephron tubule development, pronephros development, protein-DNA complex assembly, regulation of Wnt signaling pathway, regulation of branch elongation involved in ureteric bud branching, regulation of pronephros size, regulation of transcription by RNA polymerase II, response to glucose, ureteric bud elongation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, identical protein binding, promoter-specific chromatin binding, protein binding, protein homodimerization activity, protein-containing complex binding, sequence-specific DNA binding, transcription cis-regulatory region binding, transcription coregulator binding; CC: cytosol, nucleoplasm, nucleus, transcription regulator complex
Pathways: Maturity onset diabetes of the young - Mus musculus (mouse)
UniProt: P27889
Entrez ID: 21410
|
Does Knockout of Gprin2 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Gprin2
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Gprin2 (G protein regulated inducer of neurite outgrowth 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D3Z1D7, A0A2I3BRN2, A0A2I3BQP8
Entrez ID: 432839
|
Does Knockout of Seh1l in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Seh1l
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Seh1l (SEH1-like (S. cerevisiae)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, cell division, cellular response to amino acid starvation, cellular response to nutrient levels, chromosome segregation, defense response to Gram-positive bacterium, mRNA transport, mitotic metaphase chromosome alignment, nuclear pore organization, nucleocytoplasmic transport, positive regulation of TORC1 signaling, protein transport, protein-containing complex localization; CC: GATOR2 complex, Seh1-associated complex, chromosome, chromosome, centromeric region, kinetochore, lysosomal membrane, lysosome, membrane, nuclear envelope, nuclear pore, nuclear pore outer ring, nucleus
Pathways: Amino acids regulate mTORC1, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mTOR signaling pathway - Mus musculus (mouse), snRNP Assembly
UniProt: Q8R2U0
Entrez ID: 72124
|
Does Knockout of Ankrd34a in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Ankrd34a
|
cell cycle progression
|
breast epithelium
|
Gene: Ankrd34a (ankyrin repeat domain 34A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q7TST1, B2RW11
Entrez ID: 545554
|
Does Knockout of Dync2li1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Dync2li1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Dync2li1 (dynein cytoplasmic 2 light intermediate chain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, determination of left/right symmetry, intraciliary retrograde transport, intraciliary transport involved in cilium assembly, regulation of cilium assembly; MF: dynein heavy chain binding; CC: apical part of cell, axoneme, cell projection, centrosome, ciliary basal body, ciliary transition zone, cilium, cytoplasm, cytoplasmic dynein complex, cytoskeleton, cytosol, dynein complex, microtubule, motile cilium, nuclear speck
Pathways: Cilium Assembly, Intraflagellar transport, Organelle biogenesis and maintenance, Salmonella infection - Mus musculus (mouse), Vasopressin-regulated water reabsorption - Mus musculus (mouse)
UniProt: Q8K0T2
Entrez ID: 213575
|
Does Knockout of S100a6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
S100a6
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: S100a6 (S100 calcium binding protein A6 (calcyclin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: S100 protein binding, calcium ion binding, calcium-dependent protein binding, metal ion binding, monoatomic ion transmembrane transporter activity, protein binding, protein homodimerization activity, tropomyosin binding, zinc ion binding; CC: cytoplasm, cytoplasmic side of plasma membrane, cytosol, extracellular matrix, membrane, nuclear envelope, nucleus, perinuclear region of cytoplasm, plasma membrane, ruffle
Pathways:
UniProt: P14069
Entrez ID: 20200
|
Does Knockout of Eif1ad in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Eif1ad
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Eif1ad (eukaryotic translation initiation factor 1A domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, translation initiation factor activity; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q3THJ3
Entrez ID: 69860
|
Does Knockout of Slc38a2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Slc38a2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Slc38a2 (solute carrier family 38, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamine import across plasma membrane, L-proline import across plasma membrane, L-serine import across plasma membrane, L-serine transport, acidic amino acid transport, alanine transport, amino acid import, amino acid transmembrane transport, amino acid transport, cellular response to amino acid starvation, cellular response to arsenite(3-), cellular response to mechanical stimulus, cerebral cortex development, female pregnancy, glutamine transport, glycine betaine transport, monoatomic ion transport, neutral amino acid transport, positive regulation of RNA splicing, positive regulation of gene expression, proline transport, regulation of cellular response to stress, regulation of glutamate secretion, neurotransmission, response to muscle activity, sodium ion transmembrane transport, sodium ion transport; MF: L-glutamine transmembrane transporter activity, L-serine transmembrane transporter activity, acidic amino acid transmembrane transporter activity, alanine:sodium symporter activity, amino acid transmembrane transporter activity, amino acid:sodium symporter activity, neutral L-amino acid transmembrane transporter activity, neutral L-amino acid:sodium symporter activity, proline:sodium symporter activity, symporter activity; CC: axon, brush border, cytoplasm, dendrite, membrane, neuronal cell body, plasma membrane, sarcolemma
Pathways: Amino acid transport across the plasma membrane, GABAergic synapse - Mus musculus (mouse), Glutamate Neurotransmitter Release Cycle, Glutamatergic synapse - Mus musculus (mouse), Neuronal System, Neurotransmitter release cycle, Protein digestion and absorption - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transmission across Chemical Synapses, Transport of small molecules
UniProt: Q8CFE6
Entrez ID: 67760
|
Does Knockout of St6galnac5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
St6galnac5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: St6galnac5 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ganglioside biosynthetic process, glycosphingolipid biosynthetic process, lipid metabolic process, oligosaccharide biosynthetic process, oligosaccharide metabolic process, protein glycosylation; MF: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity, glycosyltransferase activity, sialyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - ganglio series - Mus musculus (mouse), Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Metabolism of proteins, Post-translational protein modification, Sialic acid metabolism, Sphingolipid metabolism, Synthesis of substrates in N-glycan biosythesis
UniProt: Q9QYJ1
Entrez ID: 26938
|
Does Knockout of Spg7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Spg7
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Spg7 (SPG7, paraplegin matrix AAA peptidase subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal transport, calcium import into the mitochondrion, cell adhesion, mitochondrial outer membrane permeabilization involved in programmed cell death, mitochondrial protein processing, mitochondrion organization, proteolysis, regulation of calcium import into the mitochondrion, regulation of cell adhesion, regulation of mitochondrial membrane permeability; MF: ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, nucleotide binding, peptidase activity, protein binding, zinc ion binding; CC: axon cytoplasm, m-AAA complex, membrane, mitochondrial inner membrane, mitochondrial permeability transition pore complex, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial calcium ion transport, Mitochondrial protein degradation, Processing of SMDT1, Transport of small molecules
UniProt: Q3ULF4
Entrez ID: 234847
|
Does Knockout of Fbxw4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Fbxw4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fbxw4 (F-box and WD-40 domain protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, Wnt signaling pathway, cartilage development, embryonic digit morphogenesis, limb development, positive regulation of mesenchymal cell proliferation
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9JMJ2
Entrez ID: 30838
|
Does Knockout of Cyb5d1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Cyb5d1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Cyb5d1 (cytochrome b5 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cilium movement, regulation of cilium beat frequency; MF: metal ion binding, molecular_function; CC: cell projection, cellular_component, cytoplasm, cytoskeleton
Pathways:
UniProt: Q5NCY3
Entrez ID: 327951
|
Does Knockout of Prpf40a in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Prpf40a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Prpf40a (pre-mRNA processing factor 40A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cell migration, cytoskeleton organization, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, regulation of cell shape, regulation of cytokinesis; MF: RNA binding, proline-rich region binding, protein binding; CC: U1 snRNP, U2-type prespliceosome, nuclear matrix, nuclear speck, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9R1C7
Entrez ID: 56194
|
Does Knockout of Ebf2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Ebf2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ebf2 (early B cell factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, brown fat cell differentiation, cell fate determination, positive regulation of DNA-templated transcription, positive regulation of cold-induced thermogenesis, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, metal ion binding, protein binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: O08792
Entrez ID: 13592
|
Does Knockout of Gin1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Gin1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gin1 (gypsy retrotransposon integrase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8K259
Entrez ID: 252876
|
Does Knockout of Dhx38 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Dhx38
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Dhx38 (DEAH-box helicase 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: 3'-5' RNA helicase activity, ATP binding, ATP-dependent activity, acting on RNA, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: catalytic step 2 spliceosome, nucleus, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q80X98
Entrez ID: 64340
|
Does Knockout of Arhgef5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Arhgef5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Arhgef5 (Rho guanine nucleotide exchange factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, hematopoietic stem cell homeostasis, intracellular signal transduction, myeloid dendritic cell chemotaxis, positive regulation of podosome assembly, positive regulation of protein import, positive regulation of stress fiber assembly, regulation of actin cytoskeleton organization, regulation of cytoskeleton organization; MF: guanyl-nucleotide exchange factor activity, lipid binding, protein binding; CC: anchoring junction, cell periphery, cell projection, cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane, podosome
Pathways: CDC42 GTPase cycle, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p75 NTR receptor-mediated signalling
UniProt: E9Q7D5
Entrez ID: 54324
|
Does Knockout of Gtpbp3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Gtpbp3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gtpbp3 (GTP binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial tRNA wobble uridine modification, tRNA methylation, tRNA modification, tRNA processing, tRNA wobble uridine modification; MF: GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, tRNA 5-taurinomethyluridine synthase activity; CC: cytoplasm, mitochondrion, nucleus, transferase complex
Pathways:
UniProt: Q923K4
Entrez ID: 70359
|
Does Knockout of Irgm1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Irgm1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Irgm1 (immunity-related GTPase family M member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CAMKK-AMPK signaling cascade, NLRP3 inflammasome complex assembly, antibacterial innate immune response, autophagosome assembly, autophagosome maturation, autophagy, cellular response to interferon-beta, cellular response to lipopolysaccharide, cellular response to type II interferon, cellular response to virus, defense response, defense response to Gram-negative bacterium, defense response to bacterium, immune system process, innate immune response, lysosome organization, negative regulation of NLRP3 inflammasome complex assembly, negative regulation of cGAS/STING signaling pathway, negative regulation of canonical NF-kappaB signal transduction, negative regulation of defense response to virus, negative regulation of hematopoietic stem cell proliferation, negative regulation of inflammatory response, negative regulation of innate immune response, negative regulation of protein localization to nucleus, negative regulation of type I interferon production, negative regulation of type II interferon production, nucleotide-binding oligomerization domain containing 2 signaling pathway, positive regulation of CD4-positive, alpha-beta T cell proliferation, positive regulation of autophagosome maturation, positive regulation of autophagy, positive regulation of lysosome organization, positive regulation of macrophage activation, positive regulation of mitochondrial fission, positive regulation of mitophagy, positive regulation of protein localization to nucleus, positive regulation of type II interferon-mediated signaling pathway, positive regulation of xenophagy, protein catabolic process, protein destabilization, protein stabilization, protein targeting to vacuole involved in autophagy, protein-containing complex assembly, regulation of mitochondrial fission, regulation of protein complex stability, regulation of protein-containing complex assembly, response to bacterium; MF: BH3 domain binding, CARD domain binding, G protein activity, GTP binding, GTPase activity, cardiolipin binding, hydrolase activity, lipid binding, nucleotide binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, protein kinase binding, protein serine/threonine kinase activator activity, protein-macromolecule adaptor activity; CC: Golgi apparatus, Golgi membrane, autolysosome, autophagosome, autophagosome membrane, cell projection, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, late endosome, late endosome membrane, lipid droplet, lysosomal membrane, lysosome, membrane, mitochondrial membrane, mitochondrion, phagocytic cup, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane
Pathways: Toxoplasmosis - Mus musculus (mouse)
UniProt: Q60766
Entrez ID: 15944
|
Does Knockout of Acsl5 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Acsl5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Acsl5 (acyl-CoA synthetase long-chain family member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid metabolic process, fatty acid transport, lipid metabolic process, long-chain fatty acid metabolic process, long-chain fatty-acyl-CoA biosynthetic process, phospholipid biosynthetic process, positive regulation of fatty acid beta-oxidation, positive regulation of long-chain fatty acid import across plasma membrane, positive regulation of triglyceride biosynthetic process, regulation of extrinsic apoptotic signaling pathway; MF: ATP binding, arachidonate-CoA ligase activity, ligase activity, long-chain fatty acid-CoA ligase activity, nucleotide binding, oleoyl-CoA ligase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion, nucleolus, nucleoplasm, plasma membrane
Pathways: Adipocytokine signaling pathway - Mus musculus (mouse), Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Ferroptosis - Mus musculus (mouse), Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), Peroxisome - Mus musculus (mouse), Synthesis of very long-chain fatty acyl-CoAs, Thermogenesis - Mus musculus (mouse), fatty acid β-oxidation I, fatty acid β-oxidation II (core pathway), fatty acid activation
UniProt: Q8JZR0
Entrez ID: 433256
|
Does Knockout of Dnajc11 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Dnajc11
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dnajc11 (DnaJ heat shock protein family (Hsp40) member C11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cristae formation; CC: MICOS complex, SAM complex, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion, nuclear speck, nucleoplasm
Pathways:
UniProt: Q5U458
Entrez ID: 230935
|
Does Knockout of Hbs1l in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Hbs1l
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Hbs1l (Hbs1-like (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of gene expression, nuclear-transcribed mRNA catabolic process, no-go decay, regulation of translation, rescue of stalled ribosome, ribosome disassembly, translation, translational elongation; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding, translation elongation factor activity; CC: Dom34-Hbs1 complex, cytoplasm, cytosolic ribosome
Pathways: Deadenylation-dependent mRNA decay, Legionellosis - Mus musculus (mouse), Metabolism of RNA, Metabolism of proteins, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome-associated quality control, Translation, mRNA decay by 3' to 5' exoribonuclease, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q69ZS7
Entrez ID: 56422
|
Does Knockout of Thsd7b in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Thsd7b
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Thsd7b (thrombospondin, type I, domain containing 7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways: Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q6P4U0
Entrez ID: 210417
|
Does Knockout of Rpl23a in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Rpl23a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rpl23a (ribosomal protein L23A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, TORC2 complex binding, large ribosomal subunit rRNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62751
Entrez ID: 268449
|
Does Knockout of Rhox4c in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Rhox4c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rhox4c (reproductive homeobox 4C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: Q2MDG1
Entrez ID: 434759
|
Does Knockout of Trib3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Trib3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trib3 (tribbles pseudokinase 3)
Type: protein-coding
Summary: Enables enzyme binding activity; transcription corepressor activity; and ubiquitin-protein transferase regulator activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of fat cell differentiation; and regulation of protein modification process. Located in nucleus. Is expressed in several structures, including bone; central nervous system; genitourinary system; heart; and retina. Orthologous to human TRIB3 (tribbles pseudokinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: apoptotic process, cellular response to insulin stimulus, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, negative regulation of DNA-templated transcription, negative regulation of MAPK cascade, negative regulation of fat cell differentiation, negative regulation of fatty acid biosynthetic process, negative regulation of insulin receptor signaling pathway, negative regulation of protein kinase activity, negative regulation of transcription by RNA polymerase II, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein ubiquitination, regulation of D-glucose transmembrane transport, regulation of MAP kinase activity, regulation of autophagy, response to endoplasmic reticulum stress; MF: ATP binding, enzyme binding, kinase activity, mitogen-activated protein kinase kinase binding, protein binding, protein kinase binding, protein kinase inhibitor activity, protein serine/threonine kinase inhibitor activity, transcription corepressor activity, ubiquitin ligase activator activity, ubiquitin protein ligase binding, ubiquitin-protein transferase regulator activity; CC: nucleoplasm, nucleus
Pathways: Activation of AKT2, Adaptive Immune System, CD28 dependent PI3K/Akt signaling, Co-stimulation by CD28, IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Insulin receptor signalling cascade, Insulin resistance - Mus musculus (mouse), Intracellular signaling by second messengers, Negative regulation of the PI3K/AKT network, PI3K Cascade, PIP3 activates AKT signaling, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by VEGF, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability
UniProt: Q8K4K2
Entrez ID: 228775
|
Does Knockout of B3galt2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
B3galt2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: B3galt2 (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: galactosylceramide biosynthetic process, lipid metabolic process, oligosaccharide biosynthetic process, protein O-linked glycosylation, protein glycosylation; MF: N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Blood group systems biosynthesis, Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: O54905
Entrez ID: 26878
|
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