prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Srpx2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Srpx2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Srpx2 (sushi-repeat-containing protein, X-linked 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell adhesion, cell motility, cell-cell adhesion, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of synapse assembly, regulation of phosphorylation, regulation of synapse assembly, vocalization behavior; MF: extracellular matrix structural constituent, hepatocyte growth factor binding, identical protein binding, signaling receptor binding; CC: cell surface, cytoplasm, excitatory synapse, extracellular matrix, extracellular region, extracellular space, glutamatergic synapse, synapse, synaptic membrane
Pathways:
UniProt: Q8R054
Entrez ID: 68792
|
Does Knockout of Mrps34 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Mrps34
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Mrps34 (mitochondrial ribosomal protein S34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9JIK9
Entrez ID: 79044
|
Does Knockout of Slc22a13 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Slc22a13
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slc22a13 (solute carrier family 22 (organic cation transporter), member 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of fatty acid metabolic process, nicotinate transport, positive regulation of T cell mediated cytotoxicity directed against tumor cell target, transmembrane transport, urate transport; MF: nicotinate transmembrane transporter activity, transmembrane transporter activity, urate transmembrane transporter activity; CC: Golgi apparatus, apical plasma membrane, endoplasmic reticulum, membrane, plasma membrane
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Nicotinate metabolism
UniProt: Q6A4L0
Entrez ID: 102570
|
Does Knockout of Hba-a1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Hba-a1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hba-a1 (hemoglobin alpha, adult chain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbon dioxide transport, erythrocyte development, in utero embryonic development, nitric oxide transport, oxygen transport, response to bacterium, response to stilbenoid; MF: G protein-coupled receptor binding, amyloid-beta binding, haptoglobin binding, heme binding, iron ion binding, metal ion binding, oxygen binding, oxygen carrier activity, peroxidase activity; CC: extracellular space, haptoglobin-hemoglobin complex, hemoglobin complex, myelin sheath
Pathways: African trypanosomiasis - Mus musculus (mouse), Malaria - Mus musculus (mouse)
UniProt: Q91VB8
Entrez ID: 15122
|
Does Knockout of Hdac10 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Hdac10
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hdac10 (histone deacetylase 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, autophagy, homologous recombination, macroautophagy, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, polyamine deacetylation, positive regulation of mismatch repair, regulation of DNA-templated transcription, spermidine deacetylation; MF: acetylputrescine deacetylase activity, acetylspermidine deacetylase activity, deacetylase activity, enzyme binding, histone deacetylase activity, histone deacetylase binding, hydrolase activity, metal ion binding, protein lysine deacetylase activity, zinc ion binding; CC: cytoplasm, cytosol, histone deacetylase complex, nucleoplasm, nucleus
Pathways: Alcoholism - Mus musculus (mouse), Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, Neutrophil extracellular trap formation - Mus musculus (mouse), Notch-HLH transcription pathway, RNA Polymerase II Transcription, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q6P3E7
Entrez ID: 170787
|
Does Knockout of Wasf1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Wasf1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Wasf1 (WASP family, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, actin cytoskeleton organization, cellular response to brain-derived neurotrophic factor stimulus, dendrite extension, dendritic transport of mitochondrion, lamellipodium morphogenesis, lamellipodium organization, mitochondrion organization, modification of postsynaptic actin cytoskeleton, neuron projection development, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of neurotrophin TRK receptor signaling pathway, receptor-mediated endocytosis; MF: Arp2/3 complex binding, actin binding, protein binding, protein kinase A binding, protein kinase A regulatory subunit binding, small GTPase binding; CC: SCAR complex, anchoring junction, cytoplasm, cytoskeleton, dendrite cytoplasm, focal adhesion, lamellipodium, mitochondrial outer membrane, mitochondrion, postsynapse, protein-containing complex, synapse
Pathways: Adherens junction - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, RAC1 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: Q8R5H6
Entrez ID: 83767
|
Does Knockout of Sh3bp1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Sh3bp1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Sh3bp1 (SH3-domain binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, cell junction assembly, cell migration, establishment of epithelial cell apical/basal polarity, filopodium assembly, negative regulation of small GTPase mediated signal transduction, phagocytosis, phagocytosis, engulfment, plasma membrane bounded cell projection assembly, positive regulation of GTPase activity, regulation of Rac protein signal transduction, regulation of actin cytoskeleton organization, regulation of actin filament depolymerization, regulation of blood vessel endothelial cell migration, ruffle assembly, semaphorin-plexin signaling pathway, signal transduction; MF: GTPase activator activity, SH3 domain binding, semaphorin receptor binding; CC: adherens junction, anchoring junction, bicellular tight junction, cell leading edge, cell projection, cytoplasm, cytosol, exocyst, lamellipodium, nucleus, phagocytic cup, plasma membrane
Pathways: RAC1 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P55194
Entrez ID: 20401
|
Does Knockout of Zfp488 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Zfp488
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp488 (zinc finger protein 488)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, nervous system development, oligodendrocyte development, positive regulation of myelination, positive regulation of oligodendrocyte differentiation, regulation of DNA-templated transcription; MF: DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q5HZG9
Entrez ID: 382867
|
Does Knockout of Rell2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Rell2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Rell2 (RELT-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell-substrate adhesion, positive regulation of p38MAPK cascade; CC: basement membrane, extracellular matrix, membrane, plasma membrane
Pathways:
UniProt: Q8BRJ3
Entrez ID: 225392
|
Does Knockout of Glt1d1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Glt1d1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Glt1d1 (glycosyltransferase 1 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: glycosyltransferase activity, molecular_function, transferase activity; CC: cytosol, extracellular region
Pathways:
UniProt: A4FUP9
Entrez ID: 319804
|
Does Knockout of Strap in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Strap
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Strap (serine/threonine kinase receptor associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, maintenance of gastrointestinal epithelium, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, neuron differentiation, protein-RNA complex assembly, retinoic acid catabolic process, retinoic acid receptor signaling pathway, spliceosomal snRNP assembly; MF: RNA binding, U2 snRNP binding, mRNA binding, protein binding, signaling receptor binding; CC: SMN complex, SMN-Sm protein complex, cytoplasm, cytosol, nucleus
Pathways: Downregulation of TGF-beta receptor signaling, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs
UniProt: Q9Z1Z2
Entrez ID: 20901
|
Does Knockout of Coa7 in Microglial Cell Line causally result in response to virus?
| 1
| 2,429
|
Knockout
|
Coa7
|
response to virus
|
Microglial Cell Line
|
Gene: Coa7 (cytochrome c oxidase assembly factor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, respiratory chain complex IV assembly; MF: molecular_function, protein-disulfide reductase activity; CC: mitochondrial intermembrane space, mitochondrion, nucleoplasm
Pathways: Thermogenesis - Mus musculus (mouse)
UniProt: Q921H9
Entrez ID: 69893
|
Does Knockout of Bicra in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Bicra
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Bicra (BRD4 interacting chromatin remodeling complex associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, negative regulation of cell differentiation, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of stem cell population maintenance, regulation of transcription by RNA polymerase II; MF: transcription regulator activator activity; CC: GBAF complex, SWI/SNF complex, chromatin, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin organization, Formation of the non-canonical BAF (ncBAF) complex, SWI/SNF chromatin remodelers
UniProt: F8VPZ9
Entrez ID: 243842
|
Does Knockout of Slc38a7 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Slc38a7
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Slc38a7 (solute carrier family 38, member 7)
Type: protein-coding
Summary: Enables L-glutamine:sodium symporter activity. Involved in glutamine transport and sodium ion transport. Located in axon and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human SLC38A7 (solute carrier family 38 member 7). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: amino acid transmembrane transport, amino acid transport, asparagine transport, glutamine transport, monoatomic ion transport, sodium ion transport; MF: L-asparagine transmembrane transporter activity, L-asparagine:sodium symporter activity, L-glutamine transmembrane transporter activity, L-glutamine:sodium symporter activity; CC: axon, cell projection, lysosomal membrane, lysosome, membrane, neuronal cell body
Pathways:
UniProt: Q8BWH0
Entrez ID: 234595
|
Does Knockout of Neurog3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Neurog3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Neurog3 (neurogenin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, cell differentiation, developmental process, enteroendocrine cell differentiation, epithelial cell differentiation, forebrain development, hindbrain development, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of DNA-templated transcription, positive regulation of cell differentiation, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of dendrite morphogenesis, sensory organ development, spinal cord development, transdifferentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, double-stranded DNA binding, protein binding, protein dimerization activity; CC: cytosol, nucleus
Pathways: Maturity onset diabetes of the young - Mus musculus (mouse)
UniProt: P70661
Entrez ID: 11925
|
Does Knockout of Psmc6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Psmc6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Psmc6 (proteasome (prosome, macropain) 26S subunit, ATPase, 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, positive regulation of RNA polymerase II transcription preinitiation complex assembly, positive regulation of inclusion body assembly, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATP binding, ATP hydrolysis activity, identical protein binding, nucleotide binding, proteasome-activating activity; CC: cytoplasm, cytosolic proteasome complex, inclusion body, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P62334
Entrez ID: 67089
|
Does Knockout of St13 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
St13
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: St13 (suppression of tumorigenicity 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein folding, response to bacterium; MF: Hsp70 protein binding, dATP binding, identical protein binding, protein dimerization activity, protein domain specific binding, protein-containing complex binding, protein-folding chaperone binding, unfolded protein binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: Q99L47
Entrez ID: 70356
|
Does Knockout of Serf2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Serf2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Serf2 (small EDRK-rich factor 2)
Type: protein-coding
Summary: Predicted to be involved in protein destabilization. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including brain; endocrine gland; genitourinary system; oral epithelium; and respiratory system. Orthologous to human SERF2 (small EDRK-rich factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, cytosol, nucleus
Pathways:
UniProt: P84102
Entrez ID: 378702
|
Does Knockout of Atg14 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Atg14
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Atg14 (autophagy related 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagosome maturation, autophagosome membrane docking, autophagy, cellular response to glucose starvation, cellular response to starvation, defense response to virus, early endosome to late endosome transport, endosome to lysosome transport, innate immune response, macroautophagy, mitophagy, negative regulation of protein phosphorylation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol-3-phosphate biosynthetic process, positive regulation of protein phosphorylation, post-transcriptional regulation of gene expression, protein targeting to lysosome, regulation of macroautophagy, regulation of protein complex stability, regulation of triglyceride metabolic process, response to mitochondrial depolarisation; MF: GTPase binding, phosphatidylinositol 3-kinase inhibitor activity, phosphatidylinositol 3-kinase regulator activity, protein binding, protein-membrane adaptor activity; CC: autophagosome, autophagosome membrane, axoneme, cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, extrinsic component of omegasome membrane, extrinsic component of phagophore assembly site membrane, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, phagocytic vesicle, phagophore assembly site, phagophore assembly site membrane, phosphatidylinositol 3-kinase complex, class III, protein-containing complex
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Macroautophagy, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q8CDJ3
Entrez ID: 100504663
|
Does Knockout of Zcchc18 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Zcchc18
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zcchc18 (zinc finger, CCHC domain containing 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, zinc ion binding
Pathways:
UniProt: Q8VD24
Entrez ID: 66995
|
Does Knockout of Tbl3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Tbl3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tbl3 (transducin (beta)-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis; CC: 90S preribosome, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8C4J7
Entrez ID: 213773
|
Does Knockout of Krt9 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Krt9
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Krt9 (keratin 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium, skin development, spermatogenesis; MF: structural constituent of skin epidermis, structural molecule activity; CC: cytoskeleton, intermediate filament, keratin filament, perinuclear region of cytoplasm
Pathways: Developmental Biology, Estrogen signaling pathway - Mus musculus (mouse), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: Q6RHW0
Entrez ID: 107656
|
Does Knockout of Sptlc1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Sptlc1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Sptlc1 (serine palmitoyltransferase, long chain base subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, lipid metabolic process, positive regulation of lipophagy, regulation of fat cell apoptotic process, sphinganine biosynthetic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingomyelin biosynthetic process, sphingosine biosynthetic process; MF: acyltransferase activity, protein binding, pyridoxal phosphate binding, serine C-palmitoyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, serine palmitoyltransferase complex
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), ceramide biosynthesis
UniProt: O35704
Entrez ID: 268656
|
Does Knockout of Oacyl in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Oacyl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Oacyl (O-acyltransferase like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acyltransferase activity, transferring groups other than amino-acyl groups, molecular_function; CC: cellular_component, membrane
Pathways:
UniProt: Q8BML2
Entrez ID: 319888
|
Does Knockout of Dapk1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Dapk1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Dapk1 (death associated protein kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, apoptotic signaling pathway, cellular response to hydroperoxide, cellular response to type II interferon, defense response to tumor cell, extrinsic apoptotic signaling pathway via death domain receptors, intracellular signal transduction, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of translation, positive regulation of apoptotic process, positive regulation of autophagic cell death, positive regulation of autophagy, protein phosphorylation, regulation of NMDA receptor activity, regulation of apoptotic process, regulation of response to tumor cell, regulation of translation, signal transduction; MF: ATP binding, GTP binding, calcium/calmodulin-dependent protein kinase activity, calmodulin binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, syntaxin-1 binding, transferase activity; CC: DAPK1-calmodulin complex, actin cytoskeleton, cytoplasm, cytosol, glutamatergic synapse, nucleus, organelle, plasma membrane, postsynaptic density
Pathways: Autophagy - animal - Mus musculus (mouse), Bladder cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: Q80YE7
Entrez ID: 69635
|
Does Knockout of Tspyl3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Tspyl3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tspyl3 (TSPY-like 3)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and histone binding activity. Predicted to be active in chromatin and nucleus. Orthologous to human TSPY26P (testis specific protein Y-linked 26, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, nucleosome assembly; MF: chromatin binding, histone binding, molecular_function; CC: chromatin, nucleus
Pathways:
UniProt: Q6PE20, Q3UYP3
Entrez ID: 241732
|
Does Knockout of Tor1aip1 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Tor1aip1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Tor1aip1 (torsin A interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear membrane organization, positive regulation of ATP-dependent activity, protein localization to nuclear envelope; MF: ATPase activator activity, ATPase binding, cytoskeletal protein binding, lamin binding, protein binding; CC: membrane, nuclear envelope, nuclear inner membrane, nuclear membrane, nucleoplasm, nucleus
Pathways: RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q921T2
Entrez ID: 208263
|
Does Knockout of Tas2r113 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Tas2r113
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Tas2r113 (taste receptor, type 2, member 113)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: Q7M711
Entrez ID: 387345
|
Does Knockout of Mir6239 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mir6239
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mir6239 (microRNA 6239)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465148
|
Does Knockout of Rpl13 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Rpl13
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rpl13 (ribosomal protein L13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, bone development, cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, nucleolus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P47963
Entrez ID: 270106
|
Does Knockout of Gatad2a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Gatad2a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gatad2a (GATA zinc finger domain containing 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior neuropore closure, blood vessel development, chromatin remodeling, embryonic body morphogenesis, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, neural fold formation, positive regulation of DNA-templated transcription, programmed cell death, regulation of cell fate specification, regulation of stem cell differentiation; MF: metal ion binding, protein-macromolecule adaptor activity, zinc ion binding; CC: NuRD complex, chromosome, nuclear speck, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Signal Transduction, Transcriptional Regulation by TP53
UniProt: Q8CHY6
Entrez ID: 234366
|
Does Knockout of Ablim1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ablim1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ablim1 (actin-binding LIM protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cilium assembly, cytoskeleton organization, lamellipodium assembly, positive regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: actin binding, actin filament binding, metal ion binding, protein binding; CC: actin cytoskeleton, cytoplasm, cytoskeleton, lamellipodium, postsynaptic density, stress fiber
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q8K4G5
Entrez ID: 226251
|
Does Knockout of Wbp2nl in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Wbp2nl
|
cell cycle progression
|
breast epithelium
|
Gene: Wbp2nl (WBP2 N-terminal like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: egg activation, female pronucleus assembly, male pronucleus assembly, positive regulation of DNA-templated transcription; MF: WW domain binding, chromatin DNA binding, transcription coactivator activity; CC: nucleus, perinuclear theca, sperm flagellum, sperm head
Pathways:
UniProt: Q9D529
Entrez ID: 74716
|
Does Knockout of Ifnar1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Ifnar1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ifnar1 (interferon (alpha and beta) receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, cell surface receptor signaling pathway via JAK-STAT, cellular response to interferon-alpha, cellular response to interferon-beta, cytokine-mediated signaling pathway, defense response to virus, gene expression, positive regulation of DNA-templated transcription, positive regulation of cellular respiration, positive regulation of interferon-beta production, positive regulation of interleukin-1 beta production, positive regulation of metabolic process, positive regulation of protein localization to nucleus, positive regulation of type II interferon production, regulation of transcription by RNA polymerase II, response to lipopolysaccharide, response to virus, type I interferon-mediated signaling pathway; MF: JAK pathway signal transduction adaptor activity, cytokine binding, interferon receptor activity, type I interferon binding, type I interferon receptor activity; CC: endosome, late endosome, lysosome, membrane, plasma membrane, receptor complex
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Regulation of IFNA/IFNB signaling, Toll-like receptor signaling pathway - Mus musculus (mouse)
UniProt: P33896
Entrez ID: 15975
|
Does Knockout of U2af1l4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
U2af1l4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: U2af1l4 (U2 small nuclear RNA auxiliary factor 1-like 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, rhythmic process; MF: RNA binding, metal ion binding, nucleic acid binding, pre-mRNA 3'-splice site binding, protein binding, zinc ion binding; CC: U2AF complex, cytoplasm, nuclear speck, nucleus, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8BGJ9
Entrez ID: 233073
|
Does Knockout of Drd2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Drd2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Drd2 (dopamine receptor D2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled dopamine receptor signaling pathway, G protein-coupled receptor internalization, G protein-coupled receptor signaling pathway, Wnt signaling pathway, acid secretion, adenohypophysis development, adenylate cyclase-inhibiting dopamine receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, adult behavior, adult walking behavior, arachidonate secretion, associative learning, auditory behavior, autophagy, axonogenesis, behavioral response to cocaine, behavioral response to ethanol, branching morphogenesis of a nerve, cellular response to ethanol, cellular response to retinoic acid, cerebral cortex GABAergic interneuron migration, circadian regulation of gene expression, dopamine metabolic process, drinking behavior, feeding behavior, forebrain development, grooming behavior, hyaloid vascular plexus regression, intracellular calcium ion homeostasis, intracellular protein localization, intracellular signal transduction, locomotory behavior, long-term memory, modulation of chemical synaptic transmission, negative regulation of G protein-coupled receptor signaling pathway, negative regulation of blood pressure, negative regulation of cell population proliferation, negative regulation of cellular response to hypoxia, negative regulation of circadian sleep/wake cycle, sleep, negative regulation of cytosolic calcium ion concentration, negative regulation of dephosphorylation, negative regulation of dopamine receptor signaling pathway, negative regulation of dopamine secretion, negative regulation of epithelial cell proliferation, negative regulation of innate immune response, negative regulation of insulin secretion, negative regulation of neuron migration, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of protein secretion, negative regulation of synaptic transmission, negative regulation of synaptic transmission, glutamatergic, nervous system process involved in regulation of systemic arterial blood pressure, neuron-neuron synaptic transmission, orbitofrontal cortex development, peristalsis, phospholipase C-activating G protein-coupled receptor signaling pathway, phospholipase C-activating dopamine receptor signaling pathway, pigmentation, positive regulation of ERK1 and ERK2 cascade, positive regulation of G protein-coupled receptor signaling pathway, positive regulation of cytokinesis, positive regulation of dopamine uptake involved in synaptic transmission, positive regulation of glial cell-derived neurotrophic factor production, positive regulation of growth hormone secretion, positive regulation of long-term synaptic potentiation, positive regulation of multicellular organism growth, positive regulation of neuroblast proliferation, positive regulation of neurogenesis, positive regulation of receptor internalization, positive regulation of renal sodium excretion, positive regulation of transcription by RNA polymerase II, positive regulation of transport, positive regulation of urine volume, postsynaptic modulation of chemical synaptic transmission, prepulse inhibition, presynaptic modulation of chemical synaptic transmission, regulation of MAPK cascade, regulation of dopamine secretion, regulation of dopamine uptake involved in synaptic transmission, regulation of heart rate, regulation of locomotion involved in locomotory behavior, regulation of long-term neuronal synaptic plasticity, regulation of neurotransmitter uptake, regulation of peptide hormone secretion, regulation of potassium ion transport, regulation of sodium ion transport, regulation of synapse structural plasticity, regulation of synaptic plasticity, regulation of synaptic transmission, GABAergic, release of sequestered calcium ion into cytosol, response to alcohol, response to amphetamine, response to axon injury, response to cocaine, response to estradiol, response to ethanol, response to histamine, response to hypoxia, response to inactivity, response to iron ion, response to light stimulus, response to morphine, response to nicotine, response to toxic substance, response to xenobiotic stimulus, sensory perception of smell, signal transduction, startle response, striatum development, synapse assembly, telencephalon development, temperature homeostasis, visual learning; MF: G protein-coupled receptor activity, G-protein alpha-subunit binding, dopamine binding, dopamine neurotransmitter receptor activity, dopamine neurotransmitter receptor activity, coupled via Gi/Go, heterotrimeric G-protein binding, identical protein binding, ionotropic glutamate receptor binding, protein binding, protein-containing complex binding, signaling receptor binding; CC: G protein-coupled receptor complex, GABA-ergic synapse, Golgi apparatus, Golgi membrane, acrosomal vesicle, axon, axon terminus, ciliary membrane, cilium, dendrite, dendritic spine, dopaminergic synapse, endocytic vesicle, glutamatergic synapse, lateral plasma membrane, membrane, non-motile cilium, perikaryon, plasma membrane, postsynaptic membrane, presynaptic membrane, sperm flagellum, synaptic vesicle membrane
Pathways: Alcoholism - Mus musculus (mouse), Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), Cocaine addiction - Mus musculus (mouse), Dopamine receptors, Dopaminergic synapse - Mus musculus (mouse), GPCR ligand binding, Gap junction - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: P61168
Entrez ID: 13489
|
Does Knockout of Zfp981 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Zfp981
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Zfp981 (zinc finger protein 981)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: A2A8V6, A2A8V7
Entrez ID: 100041433
|
Does Knockout of Eif2s3y in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Eif2s3y
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Eif2s3y (eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked)
Type: protein-coding
Summary: Predicted to enable translation initiation factor activity. Predicted to contribute to tRNA binding activity. Acts upstream of or within positive regulation of male gonad development and spermatogenesis. Predicted to be part of eukaryotic translation initiation factor 2 complex. Is expressed in several structures, including cerebral cortex; genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to human EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cytoplasmic translational initiation, formation of translation preinitiation complex, positive regulation of male gonad development, spermatogenesis, translation, translational initiation; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, tRNA binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, eukaryotic translation initiation factor 2 complex
Pathways:
UniProt: Q9Z0N2
Entrez ID: 26908
|
Does Knockout of Ddx28 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Ddx28
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Ddx28 (DEAD box helicase 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial large ribosomal subunit assembly, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, rRNA binding; CC: cytosol, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleolus, nucleoplasm, nucleus, ribonucleoprotein granule
Pathways:
UniProt: Q9CWT6
Entrez ID: 71986
|
Does Knockout of Itgb3bp in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Itgb3bp
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Itgb3bp (integrin beta 3 binding protein (beta3-endonexin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CENP-A containing chromatin assembly, apoptotic process, cell division, chromosome segregation, negative regulation of epithelial cell apoptotic process, positive regulation of epithelial cell proliferation, regulation of DNA-templated transcription; CC: chromosome, chromosome, centromeric region, inner kinetochore, kinetochore, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell death signalling via NRAGE, NRIF and NADE, Chromosome Maintenance, Death Receptor Signaling, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, NRIF signals cell death from the nucleus, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p75 NTR receptor-mediated signalling
UniProt: Q9CQ82
Entrez ID: 67733
|
Does Knockout of Ubr4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ubr4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ubr4 (ubiquitin protein ligase E3 component n-recognin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: HRI-mediated signaling, cellular response to stress, cytoplasm protein quality control, cytoplasm protein quality control by the ubiquitin-proteasome system, endosome organization, fatty acid biosynthetic process, negative regulation of HRI-mediated signaling, negative regulation of fatty acid biosynthetic process, positive regulation of autophagy, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins, protein stabilization, protein targeting to vacuole involved in autophagy, protein ubiquitination, response to oxidative stress, translational initiation, type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the N-end rule pathway; MF: calmodulin binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytoskeleton, cytosol, endosome, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation, Viral carcinogenesis - Mus musculus (mouse)
UniProt: A2AN08
Entrez ID: 69116
|
Does Knockout of Ivd in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 0
| 2,474
|
Knockout
|
Ivd
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Ivd (isovaleryl coenzyme A dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-leucine catabolic process, branched-chain amino acid catabolic process, fatty acid beta-oxidation using acyl-CoA dehydrogenase; MF: 3-methylbutanoyl-CoA dehydrogenase activity, acyl-CoA dehydrogenase activity, flavin adenine dinucleotide binding, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, short-chain fatty acyl-CoA dehydrogenase activity; CC: mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways: Branched-chain amino acid catabolism, Leucine Catabolism, Metabolism, Metabolism of amino acids and derivatives, Valine, leucine and isoleucine degradation - Mus musculus (mouse), leucine degradation I
UniProt: Q9JHI5
Entrez ID: 56357
|
Does Knockout of Tyk2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Tyk2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tyk2 (tyrosine kinase 2)
Type: protein-coding
Summary: Predicted to enable growth hormone receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and type 1 angiotensin receptor binding activity. Involved in cell population proliferation and positive regulation of T cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of interleukin-12 receptor complex and interleukin-23 receptor complex. Predicted to be active in cytosol. Used to study obesity. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human TYK2 (tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell differentiation, cell population proliferation, cell surface receptor signaling pathway via JAK-STAT, cytokine-mediated signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, immune response, interleukin-10-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-23-mediated signaling pathway, intracellular signal transduction, positive regulation of NK T cell proliferation, positive regulation of T cell proliferation, positive regulation of T-helper 17 type immune response, positive regulation of interleukin-17 production, positive regulation of natural killer cell proliferation, positive regulation of protein localization to nucleus, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of type II interferon production, regulation of T cell activation, regulation of leukocyte cell-cell adhesion, regulation of transcription by RNA polymerase II, type I interferon-mediated signaling pathway, type II interferon-mediated signaling pathway; MF: ATP binding, growth hormone receptor binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, type 1 angiotensin receptor binding; CC: cytoplasm, cytosol, interleukin-12 receptor complex, interleukin-23 receptor complex, membrane, nucleus, plasma membrane, receptor complex
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IL-6-type cytokine receptor ligand interactions, Immune System, Inactivation of CSF3 (G-CSF) signaling, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, Interleukin-10 signaling, Interleukin-12 family signaling, Interleukin-12 signaling, Interleukin-20 family signaling, Interleukin-23 signaling, Interleukin-27 signaling, Interleukin-35 Signalling, Interleukin-4 and Interleukin-13 signaling, Interleukin-6 family signaling, Interleukin-6 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), MAPK family signaling cascades, MAPK1 (ERK2) activation, MAPK1/MAPK3 signaling, MAPK3 (ERK1) activation, Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), RAF-independent MAPK1/3 activation, Regulation of IFNA/IFNB signaling, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by Interleukins, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse)
UniProt: Q9R117
Entrez ID: 54721
|
Does Knockout of Egln1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Egln1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Egln1 (egl-9 family hypoxia-inducible factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle tissue morphogenesis, cellular response to hypoxia, heart trabecula formation, intracellular iron ion homeostasis, intracellular oxygen homeostasis, labyrinthine layer development, negative regulation of CAMKK-AMPK signaling cascade, negative regulation of hypoxia-inducible factor-1alpha signaling pathway, positive regulation of apoptotic process, positive regulation of neuron apoptotic process, positive regulation of transcription by RNA polymerase II, regulation of angiogenesis, regulation of modification of postsynaptic structure, regulation of neuron apoptotic process, regulation protein catabolic process at postsynapse, response to hypoxia, response to nitric oxide, ventricular septum morphogenesis; MF: 2-oxoglutarate-dependent dioxygenase activity, L-ascorbic acid binding, dioxygenase activity, enzyme binding, enzyme inhibitor activity, ferrous iron binding, hypoxia-inducible factor-proline dioxygenase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, peptidyl-proline 4-dioxygenase activity, peptidyl-proline dioxygenase activity, zinc ion binding; CC: cytoplasm, cytosol, glutamatergic synapse, nucleus, postsynaptic density
Pathways: Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, HIF-1 signaling pathway - Mus musculus (mouse), Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Pathways in cancer - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse)
UniProt: Q91YE3
Entrez ID: 112405
|
Does Knockout of Rfng in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Rfng
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Rfng (RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)
Type: protein-coding
Summary: Enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in regulation of Notch signaling pathway. Acts upstream of or within positive regulation of Notch signaling pathway. Predicted to be located in Golgi membrane. Is expressed in several structures, including central nervous system; genitourinary system; limb; retina; and small intestine. Orthologous to human RFNG (RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, negative regulation of Notch signaling pathway, nervous system development, pattern specification process, positive regulation of Notch signaling pathway, regulation of Notch signaling pathway; MF: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity, glycosyltransferase activity, metal ion binding, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Human papillomavirus infection - Mus musculus (mouse), Notch signaling pathway - Mus musculus (mouse), Other types of O-glycan biosynthesis - Mus musculus (mouse)
UniProt: O09009
Entrez ID: 19719
|
Does Knockout of Map7d1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Map7d1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Map7d1 (MAP7 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization; CC: centrosome, cytoplasm, cytoskeleton, microtubule cytoskeleton, midbody, spindle
Pathways:
UniProt: A2AJI0
Entrez ID: 245877
|
Does Knockout of Prkdc in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,528
|
Knockout
|
Prkdc
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Prkdc (protein kinase, DNA activated, catalytic polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell lineage commitment, DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, T cell differentiation in thymus, T cell lineage commitment, T cell receptor V(D)J recombination, V(D)J recombination, activation of innate immune response, brain development, cGAS/STING signaling pathway, cellular response to insulin stimulus, double-strand break repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, ectopic germ cell programmed cell death, heart development, immature B cell differentiation, immune system process, immunoglobulin V(D)J recombination, innate immune response, intrinsic apoptotic signaling pathway in response to DNA damage, lymphocyte differentiation, maturation of 5.8S rRNA, mitotic G1 DNA damage checkpoint signaling, negative regulation of apoptotic process, negative regulation of cGAS/STING signaling pathway, negative regulation of cellular senescence, negative regulation of immunoglobulin production, negative regulation of protein phosphorylation, negative regulation of response to gamma radiation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of apoptotic process, positive regulation of biosynthetic process, positive regulation of developmental growth, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of erythrocyte differentiation, positive regulation of fibroblast proliferation, positive regulation of immune system process, positive regulation of lymphocyte differentiation, positive regulation of platelet formation, positive regulation of transcription by RNA polymerase II, positive regulation of translation, pro-B cell differentiation, protein destabilization, protein localization to chromatin, regulation of circadian rhythm, regulation of epithelial cell proliferation, regulation of hematopoietic stem cell differentiation, regulation of smooth muscle cell proliferation, replication fork processing, response to activity, response to gamma radiation, response to ionizing radiation, rhythmic process, ribosome biogenesis, small-subunit processome assembly, somitogenesis, spleen development, telomere capping, telomere maintenance, thymus development; MF: ATP binding, DNA-dependent protein kinase activity, RNA polymerase II-specific DNA-binding transcription factor binding, U3 snoRNA binding, double-stranded DNA binding, enzyme binding, histone H2AXS139 kinase activity, kinase activity, nucleotide binding, protein binding, protein domain specific binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: DNA-dependent protein kinase complex, DNA-dependent protein kinase-DNA ligase 4 complex, chromatin, cytoplasm, cytosol, nonhomologous end joining complex, nucleolus, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, small-subunit processome, transcription regulator complex
Pathways: Cell cycle - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Protein ubiquitination
UniProt: P97313
Entrez ID: 19090
|
Does Knockout of Glud1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Glud1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Glud1 (glutamate dehydrogenase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamate catabolic process, amino acid metabolic process, glutamine metabolic process, positive regulation of insulin secretion, response to aluminum ion, tricarboxylic acid metabolic process; MF: ADP binding, ATP binding, GTP binding, L-leucine binding, NAD+ binding, enzyme binding, glutamate dehydrogenase (NAD+) activity, glutamate dehydrogenase (NADP+) activity, glutamate dehydrogenase [NAD(P)+] activity, nucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor, protein binding, protein homodimerization activity; CC: cytoplasm, endoplasmic reticulum, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Arginine biosynthesis - Mus musculus (mouse), Glutamate and glutamine metabolism, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Mitochondrial biogenesis, Mitochondrial protein degradation, Necroptosis - Mus musculus (mouse), Nitrogen metabolism - Mus musculus (mouse), Organelle biogenesis and maintenance, Proximal tubule bicarbonate reclamation - Mus musculus (mouse), Transcriptional activation of mitochondrial biogenesis, arginine biosynthesis IV, glutamate biosynthesis II, glutamate degradation X, glutamine biosynthesis II, glutamine degradation I, proline biosynthesis II
UniProt: P26443
Entrez ID: 14661
|
Does Knockout of Adamts9 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Adamts9
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Adamts9 (ADAM metallopeptidase with thrombospondin type 1 motif 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye morphogenesis, cornea development in camera-type eye, extracellular matrix organization, lens development in camera-type eye, positive regulation of melanocyte differentiation, proteolysis, regulation of developmental pigmentation, response to bacterium; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: cell surface, endoplasmic reticulum, extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: E9PUN6, E9PYV8
Entrez ID: 101401
|
Does Knockout of Zfp532 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Zfp532
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp532 (zinc finger protein 532)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q6NXK2
Entrez ID: 328977
|
Does Knockout of Coa4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Coa4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Coa4 (cytochrome c oxidase assembly factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial intermembrane space, mitochondrion
Pathways: Thermogenesis - Mus musculus (mouse)
UniProt: Q8BT51
Entrez ID: 68185
|
Does Knockout of Nxf1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Nxf1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nxf1 (nuclear RNA export factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, mRNA export from nucleus, mRNA transport, poly(A)+ mRNA export from nucleus, protein transport; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding; CC: cytoplasm, cytoplasmic stress granule, nuclear RNA export factor complex, nuclear envelope, nuclear inclusion body, nuclear pore, nuclear speck, nucleoplasm, nucleus, transcription export complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q99JX7
Entrez ID: 53319
|
Does Knockout of Tapbp in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Tapbp
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Tapbp (TAP binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MHC class Ib protein complex assembly, antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, antigen processing and presentation of peptide antigen via MHC class I, defense response, peptide antigen assembly with MHC class I protein complex, peptide antigen stabilization, protein-containing complex assembly, regulation of gene expression, regulation of protein complex stability; MF: MHC class I protein complex binding, TAP complex binding, TAP1 binding, TAP2 binding, molecular adaptor activity, peptide antigen binding, protein binding, protein folding chaperone; CC: Golgi membrane, MHC class I peptide loading complex, Tapasin-ERp57 complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, phagocytic vesicle membrane, plasma membrane
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, ER-Phagosome pathway, Epstein-Barr virus infection - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System
UniProt: Q9R233
Entrez ID: 21356
|
Does Knockout of B3gnt7 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
B3gnt7
|
protein/peptide accumulation
|
Mouse cell
|
Gene: B3gnt7 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: keratan sulfate proteoglycan biosynthetic process, poly-N-acetyllactosamine biosynthetic process, protein O-linked glycosylation, protein glycosylation; MF: UDP-glycosyltransferase activity, acetylglucosaminyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosaminoglycan biosynthesis - keratan sulfate - Mus musculus (mouse), Glycosaminoglycan metabolism, Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: Q8K0J2
Entrez ID: 227327
|
Does Knockout of Tmem132e in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Tmem132e
|
cell proliferation
|
Regulatory T cell
|
Gene: Tmem132e (transmembrane protein 132E)
Type: protein-coding
Summary: Predicted to be involved in posterior lateral line neuromast hair cell development. Located in cell body. Is expressed in nervous system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 99. Orthologous to human TMEM132E (transmembrane protein 132E). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: posterior lateral line neuromast hair cell development; CC: cell body, membrane
Pathways:
UniProt: Q6IEE6
Entrez ID: 270893
|
Does Knockout of Zdbf2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Zdbf2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Zdbf2 (zinc finger, DBF-type containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epigenetic programming of gene expression, genomic imprinting
Pathways:
UniProt: Q5SS00
Entrez ID: 73884
|
Does Knockout of Map3k21 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Map3k21
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Map3k21 (mitogen-activated protein kinase kinase kinase 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, signal transduction; MF: ATP binding, JUN kinase kinase kinase activity, MAP kinase kinase kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: Q8VDG6
Entrez ID: 234878
|
Does Knockout of Cybb in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Cybb
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cybb (cytochrome b-245, beta polypeptide)
Type: protein-coding
Summary: This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013].
Gene Ontology: BP: cellular response to L-glutamine, cellular response to cadmium ion, cellular response to ethanol, cellular response to hypoxia, defense response, hydrogen peroxide biosynthetic process, hypoxia-inducible factor-1alpha signaling pathway, inflammatory response, innate immune response, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of angiogenesis, positive regulation of tumor necrosis factor production, respiratory burst, response to aldosterone, response to angiotensin, response to ethanol, response to nutrient, response to xenobiotic stimulus, superoxide anion generation, superoxide metabolic process; MF: FAD binding, NAD(P)H oxidase H2O2-forming activity, NADPH binding, electron transfer activity, flavin adenine dinucleotide binding, heme binding, metal ion binding, oxidoreductase activity, protein binding, protein heterodimerization activity, superoxide-generating NAD(P)H oxidase activity, superoxide-generating NADPH oxidase activity, voltage-gated proton channel activity; CC: NADPH oxidase complex, cytoplasm, dendrite, membrane, mitochondrion, monoatomic ion channel complex, neuronal cell body, nuclear envelope, perinuclear endoplasmic reticulum, phagocytic vesicle, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adaptive Immune System, Alzheimer disease - Mus musculus (mouse), Antigen processing-Cross presentation, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Cross-presentation of particulate exogenous antigens (phagosomes), Detoxification of Reactive Oxygen Species, Diabetic cardiomyopathy - Mus musculus (mouse), Ferroptosis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Leishmaniasis - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Neutrophil degranulation, Neutrophil extracellular trap formation - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate NADPH Oxidases, ROS and RNS production in phagocytes, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: Q61093
Entrez ID: 13058
|
Does Knockout of Ces2d-ps in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Ces2d-ps
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ces2d-ps (carboxylesterase 2D, pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 667754
|
Does Knockout of Esco2 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,558
|
Knockout
|
Esco2
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Esco2 (establishment of sister chromatid cohesion N-acetyltransferase 2)
Type: protein-coding
Summary: Enables L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Acts upstream of or within several processes, including double-strand break repair; hematopoietic progenitor cell differentiation; and protein localization to chromatin. Located in chromocenter and chromosome. Is expressed in several structures, including alimentary system; brain; gonad; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Roberts syndrome and lung adenocarcinoma. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromosome segregation, double-strand break repair, hematopoietic progenitor cell differentiation, mitotic sister chromatid cohesion, protein localization to chromatin, regulation of DNA replication; MF: L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, acetyltransferase activity, acyltransferase activity, metal ion binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: Golgi apparatus, XY body, cell junction, chromatin, chromocenter, chromosome, nucleoplasm, nucleus, pericentric heterochromatin, site of double-strand break
Pathways: Cell Cycle, Cell Cycle, Mitotic, Establishment of Sister Chromatid Cohesion, S Phase
UniProt: Q8CIB9
Entrez ID: 71988
|
Does Knockout of Adh1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Adh1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adh1 (alcohol dehydrogenase 1 (class I))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ regeneration, behavioral response to ethanol, ethanol catabolic process, lipid metabolic process, response to ethanol, response to progesterone, response to retinoic acid, response to steroid hormone, response to testosterone, retinoic acid metabolic process, retinoid metabolic process, retinol metabolic process, small molecule catabolic process; MF: alcohol dehydrogenase (NAD+) activity, all-trans-retinol dehydrogenase (NAD+) activity, identical protein binding, metal ion binding, oxidoreductase activity, zinc ion binding; CC: ciliary basal body, cilium, cytoplasm, cytosol, mitochondrion, nucleoplasm, plasma membrane
Pathways: Abacavir ADME, Abacavir metabolism, Alcoholic liver disease - Mus musculus (mouse), Biological oxidations, Drug ADME, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Ethanol oxidation, Fatty acid degradation - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Phase I - Functionalization of compounds, Pyruvate metabolism - Mus musculus (mouse), RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, Tyrosine metabolism - Mus musculus (mouse), ethanol degradation II (cytosol), phenylalanine degradation III
UniProt: P00329
Entrez ID: 11522
|
Does Knockout of F11 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
F11
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: F11 (coagulation factor XI)
Type: protein-coding
Summary: This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and bacterial accumulation upon infection with Listeria. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: blood coagulation, hemostasis, plasminogen activation, positive regulation of fibrinolysis, proteolysis, regulation of blood coagulation; MF: heparin binding, hydrolase activity, identical protein binding, peptidase activity, serine-type aminopeptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region, extracellular space
Pathways: Complement and coagulation cascades - Mus musculus (mouse), Formation of Fibrin Clot (Clotting Cascade), Hemostasis, Intrinsic Pathway of Fibrin Clot Formation
UniProt: Q91Y47
Entrez ID: 109821
|
Does Knockout of Apoo in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Apoo
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Apoo (apolipoprotein O)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cristae formation; CC: Golgi apparatus, Golgi membrane, MICOS complex, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular region, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9DCZ4
Entrez ID: 68316
|
Does Knockout of Tgfbrap1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Tgfbrap1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tgfbrap1 (transforming growth factor, beta receptor associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, endosomal vesicle fusion, endosome to lysosome transport, intracellular protein transport, protein transport, regulation of DNA-templated transcription, signal transduction, vesicle-mediated transport; MF: SMAD binding, transforming growth factor beta receptor binding; CC: CORVET complex, cytoplasm, early endosome, endomembrane system, endosome, membrane
Pathways:
UniProt: Q3UR70
Entrez ID: 73122
|
Does Knockout of Rps2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Rps2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Rps2 (ribosomal protein S2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-4, cytoplasmic translation, translation; MF: RNA binding, enzyme binding, fibroblast growth factor binding, mRNA binding, protein-containing complex binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleoplasm, nucleus, postsynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Chromatin modifying enzymes, Chromatin organization, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Post-translational protein modification, Protein methylation, RMTs methylate histone arginines, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P25444
Entrez ID: 16898
|
Does Knockout of Col28a1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Col28a1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Col28a1 (collagen, type XXVIII, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: extracellular matrix structural constituent conferring tensile strength, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: basement membrane, collagen trimer, extracellular matrix, extracellular region
Pathways: Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen formation, Extracellular matrix organization, Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q2UY11
Entrez ID: 213945
|
Does Knockout of Rock1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Rock1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rock1 (Rho-associated coiled-coil containing protein kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, actin cytoskeleton organization, actomyosin structure organization, apical constriction, apoptotic process, bleb assembly, blood vessel diameter maintenance, cortical actin cytoskeleton organization, cytoskeleton organization, embryonic morphogenesis, epithelial to mesenchymal transition, intracellular signal transduction, leukocyte cell-cell adhesion, leukocyte migration, leukocyte tethering or rolling, mRNA destabilization, membrane to membrane docking, mitotic cytokinesis, myoblast migration, negative regulation of amyloid precursor protein catabolic process, negative regulation of amyloid-beta formation, negative regulation of angiogenesis, negative regulation of bicellular tight junction assembly, negative regulation of motor neuron apoptotic process, neuron projection arborization, neuron projection development, podocyte cell migration, positive regulation of MAPK cascade, positive regulation of amyloid-beta clearance, positive regulation of autophagy, positive regulation of cardiac muscle hypertrophy, positive regulation of connective tissue replacement, positive regulation of focal adhesion assembly, positive regulation of gene expression, positive regulation of macromolecule metabolic process, protein localization to plasma membrane, regulation of actin cytoskeleton organization, regulation of actin filament-based process, regulation of angiotensin-activated signaling pathway, regulation of cell junction assembly, regulation of cell migration, regulation of establishment of endothelial barrier, regulation of gene expression, regulation of keratinocyte differentiation, regulation of microtubule cytoskeleton organization, regulation of neuron differentiation, regulation of synapse maturation, regulation of synaptic vesicle endocytosis, response to angiotensin, response to transforming growth factor beta, signal transduction; MF: ATP binding, Rho-dependent protein serine/threonine kinase activity, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, small GTPase binding, transferase activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, Schaffer collateral - CA1 synapse, bleb, cell projection, centriole, cytoplasm, cytoplasmic stress granule, cytoskeleton, lamellipodium, membrane, plasma membrane, ruffle, synapse
Pathways: Axon guidance - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P70335
Entrez ID: 19877
|
Does Knockout of Gata5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Gata5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gata5 (GATA binding protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aortic valve morphogenesis, cardiac jelly development, cardiac muscle tissue development, cell fate commitment, cellular response to BMP stimulus, cellular response to hydrogen peroxide, cellular response to nitric oxide, endocardial cushion fusion, heart development, heart induction, intestinal epithelial cell differentiation, negative regulation of cardiac muscle hypertrophy, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of Notch signaling pathway, positive regulation of apoptotic DNA fragmentation, positive regulation of cardiac endothelial to mesenchymal transition, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of multicellular organismal process, regulation of transcription by RNA polymerase II, tissue development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: chromatin, nucleus
Pathways: Factors involved in megakaryocyte development and platelet production, Hemostasis
UniProt: P97489
Entrez ID: 14464
|
Does Knockout of Rps23 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Rps23
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rps23 (ribosomal protein S23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, maintenance of translational fidelity, ribosomal small subunit biogenesis, stress granule assembly, translation; MF: protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, nucleolus, nucleus, postsynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Post-translational protein modification, Protein hydroxylation, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62267
Entrez ID: 66475
|
Does Knockout of Rpl13a-ps1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Rpl13a-ps1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rpl13a-ps1 (ribosomal protein 13A, pseudogene 1)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 433251
|
Does Knockout of Aatf in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Aatf
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Aatf (apoptosis antagonizing transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, embryonic cleavage, negative regulation of amyloid precursor protein biosynthetic process, negative regulation of apoptotic process, negative regulation of apoptotic signaling pathway, positive regulation of DNA-templated transcription, regulation of mitotic cell cycle, ribosomal small subunit biogenesis, ribosome biogenesis; MF: leucine zipper domain binding, protein binding, protein kinase binding, tau protein binding; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome, transcription regulator complex
Pathways:
UniProt: Q9JKX4
Entrez ID: 56321
|
Does Knockout of Tnks1bp1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Tnks1bp1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tnks1bp1 (tankyrase 1 binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to ionizing radiation, double-strand break repair; MF: ankyrin repeat binding, enzyme binding, protein serine/threonine kinase activator activity, protein-containing complex binding; CC: CCR4-NOT complex, adherens junction, chromosome, cytoplasm, cytoskeleton, cytosol, heterochromatin, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: P58871
Entrez ID: 228140
|
Does Knockout of Nap1l3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Nap1l3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nap1l3 (nucleosome assembly protein 1-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly; MF: chromatin binding, histone binding; CC: chromatin, cytoplasm, nucleus
Pathways:
UniProt: Q794H2
Entrez ID: 54561
|
Does Knockout of Rpl4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Rpl4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Rpl4 (ribosomal protein L4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: 5S rRNA binding, RNA binding, protein binding, structural constituent of ribosome; CC: A band, cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, large ribosomal subunit, nuclear body, nucleolus, nucleus, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D8E6
Entrez ID: 67891
|
Does Knockout of Lrp12 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Lrp12
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Lrp12 (low density lipoprotein-related protein 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell migration, endocytosis, integrin activation, lymphocyte migration into lymphoid organs, neuron migration, neuron projection development; MF: integrin binding, molecular_function; CC: clathrin-coated pit, membrane, plasma membrane
Pathways: Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Retinoid metabolism and transport, Sensory Perception, Visual phototransduction
UniProt: Q8BUJ9
Entrez ID: 239393
|
Does Knockout of Hnrnpul1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Hnrnpul1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Hnrnpul1 (heterogeneous nuclear ribonucleoprotein U-like 1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity and enzyme binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Is active in synapse. Orthologous to human HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U like 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: RNA binding, enzyme binding; CC: nucleoplasm, nucleus, ribonucleoprotein complex, synapse
Pathways: Influenza A - Mus musculus (mouse)
UniProt: Q8VDM6
Entrez ID: 232989
|
Does Knockout of Itm2c in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Itm2c
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Itm2c (integral membrane protein 2C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of amyloid precursor protein biosynthetic process, negative regulation of neuron projection development, neuron differentiation, positive regulation of extrinsic apoptotic signaling pathway; MF: ATP binding, amyloid-beta binding; CC: Golgi apparatus, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q91VK4
Entrez ID: 64294
|
Does Knockout of Hk1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Hk1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Hk1 (hexokinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GDP-mannose biosynthetic process from mannose, canonical glycolysis, carbohydrate metabolic process, carbohydrate phosphorylation, establishment of protein localization to mitochondrion, fructose 6-phosphate metabolic process, glucose 6-phosphate metabolic process, glucose metabolic process, glycolytic process, hexose metabolic process, immune system process, inflammatory response, innate immune response, intracellular glucose homeostasis, maintenance of protein location in mitochondrion, mannose metabolic process, negative regulation of apoptotic process, positive regulation of cytokine production involved in immune response, positive regulation of interleukin-1 beta production, response to ischemia; MF: ATP binding, D-glucose binding, catalytic activity, fructokinase activity, glucokinase activity, glucosamine kinase activity, hexokinase activity, identical protein binding, kinase activity, mannokinase activity, nucleotide binding, peptidoglycan binding, phosphotransferase activity, alcohol group as acceptor, protein binding, protein kinase activity, protein-containing complex binding, transferase activity; CC: caveola, cilium, cytoplasm, cytosol, membrane, membrane raft, mitochondrial outer membrane, mitochondrion, protein-containing complex, sperm principal piece
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Carbohydrate digestion and absorption - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Fructose and mannose metabolism - Mus musculus (mouse), GDP-mannose metabolism, Galactose metabolism - Mus musculus (mouse), Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, Neomycin, kanamycin and gentamicin biosynthesis - Mus musculus (mouse), Post-translational protein modification, Starch and sucrose metabolism - Mus musculus (mouse), Synthesis of GDP-mannose, Synthesis of substrates in N-glycan biosythesis, Type II diabetes mellitus - Mus musculus (mouse), mannitol degradation II, starch degradation, sucrose degradation
UniProt: P17710
Entrez ID: 15275
|
Does Knockout of Gm10604 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Gm10604
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gm10604 (predicted gene 10604)
Type: unknown
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100038424
|
Does Knockout of Defa23 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Defa23
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Defa23 (defensin, alpha, 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, disruption of plasma membrane integrity in another organism, innate immune response, killing by host of symbiont cells, killing of cells of another organism, positive regulation of interleukin-8 production, positive regulation of membrane permeability, protein homotetramerization; MF: pore-forming activity, protein homodimerization activity; CC: extracellular region, extracellular space, midbody, secretory granule
Pathways: Alpha-defensins, Antimicrobial peptides, Defensins, Immune System, Innate Immune System, NOD-like receptor signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Staphylococcus aureus infection - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q5G866
Entrez ID: 497114
|
Does Knockout of Map3k7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Map3k7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Map3k7 (mitogen-activated protein kinase kinase kinase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: I-kappaB phosphorylation, JNK cascade, MAPK cascade, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, angiogenesis, anoikis, apoptotic process, bone development, cGAS/STING signaling pathway, canonical NF-kappaB signal transduction, cellular response to angiotensin, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, defense response to bacterium, immune response, inflammatory response, interleukin-17A-mediated signaling pathway, interleukin-33-mediated signaling pathway, negative regulation of apoptotic signaling pathway, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cytokine production involved in inflammatory response, negative regulation of gene expression, negative regulation of necroptotic process, negative regulation of reactive oxygen species metabolic process, negative regulation of ripoptosome assembly involved in necroptotic process, neural tube formation, non-canonical NF-kappaB signal transduction, osteoblast differentiation, p38MAPK cascade, positive regulation of JNK cascade, positive regulation of JUN kinase activity, positive regulation of MAPK cascade, positive regulation of T cell cytokine production, positive regulation of autophagy, positive regulation of cGAS/STING signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell cycle, positive regulation of cell size, positive regulation of interleukin-2 production, positive regulation of macroautophagy, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of type I interferon production, positive regulation of vascular associated smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, protein exit from endoplasmic reticulum, protein phosphorylation, regulation of reactive oxygen species metabolic process, signal transduction, signal transduction in response to DNA damage, signal transduction involved in regulation of gene expression, stress-activated MAPK cascade, toll-like receptor 4 signaling pathway, transforming growth factor beta receptor signaling pathway; MF: ATP binding, DNA-binding transcription factor binding, MAP kinase activity, MAP kinase kinase activity, MAP kinase kinase kinase activity, MAP kinase kinase kinase kinase activity, histone kinase activity, identical protein binding, kinase activity, linear polyubiquitin binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine kinase binding, receptor tyrosine kinase binding, scaffold protein binding, signaling receptor binding, transcription coactivator binding, transferase activity, type II transforming growth factor beta receptor binding, ubiquitin protein ligase binding; CC: ATAC complex, cytoplasm, cytosol, endoplasmic reticulum membrane, membrane, plasma membrane, postsynaptic density
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adaptive Immune System, Adherens junction - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Alpha-protein kinase 1 signaling pathway, Autophagy - animal - Mus musculus (mouse), Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Ca2+ pathway, Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Death Receptor Signaling, Deubiquitination, Downstream TCR signaling, Epstein-Barr virus infection - Mus musculus (mouse), FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), IRAK2 mediated activation of TAK1 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), NOD1/2 Signaling Pathway, Neutrophil extracellular trap formation - Mus musculus (mouse), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Osteoclast differentiation - Mus musculus (mouse), Post-translational protein modification, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Signaling by WNT, T cell receptor signaling pathway - Mus musculus (mouse), TAK1-dependent IKK and NF-kappa-B activation , TCR signaling, TNF signaling, TNF signaling pathway - Mus musculus (mouse), TNFR1-induced NF-kappa-B signaling pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Ub-specific processing proteases, Wnt signaling pathway - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), activated TAK1 mediates p38 MAPK activation
UniProt: Q62073
Entrez ID: 26409
|
Does Knockout of Slitrk3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Slitrk3
|
cell cycle progression
|
breast epithelium
|
Gene: Slitrk3 (SLIT and NTRK-like family, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, gephyrin clustering involved in postsynaptic density assembly, neurotransmitter-gated ion channel clustering, positive regulation of synapse assembly, postsynaptic density assembly, regulation of presynapse assembly, synaptic membrane adhesion, synaptic transmission, GABAergic, terminal button organization; CC: GABA-ergic synapse, cell surface, membrane, postsynaptic density membrane, postsynaptic membrane, postsynaptic specialization membrane
Pathways: Neuronal System, Protein-protein interactions at synapses, RAC3 GTPase cycle, RHO GTPase cycle, Receptor-type tyrosine-protein phosphatases, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q810B9
Entrez ID: 386750
|
Does Knockout of Mtpap in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Mtpap
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mtpap (mitochondrial poly(A) polymerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, RNA metabolic process, histone mRNA catabolic process, mRNA processing, mitochondrial RNA 3'-end processing, mitochondrial mRNA polyadenylation; MF: ATP binding, RNA binding, UTP binding, identical protein binding, magnesium ion binding, manganese ion binding, metal ion binding, nucleotide binding, poly(A) RNA polymerase activity, protein homodimerization activity, transferase activity; CC: cytoplasm, mitochondrion, nucleoplasm
Pathways:
UniProt: Q9D0D3
Entrez ID: 67440
|
Does Knockout of Zfp532 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Zfp532
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp532 (zinc finger protein 532)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q6NXK2
Entrez ID: 328977
|
Does Knockout of Satl1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Satl1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Satl1 (spermidine/spermine N1-acetyl transferase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: polyamine metabolic process, spermidine acetylation; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, diamine N-acetyltransferase activity, spermidine binding, transferase activity
Pathways:
UniProt: Q9D5N8
Entrez ID: 73809
|
Does Knockout of Fancf in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,536
|
Knockout
|
Fancf
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Fancf (Fanconi anemia, complementation group F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, interstrand cross-link repair, ovarian follicle development, protein ubiquitination, spermatogenesis; CC: Fanconi anaemia nuclear complex, chromatin, nucleoplasm, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: E9Q5Z5
Entrez ID: 100040608
|
Does Knockout of Msi1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Msi1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Msi1 (musashi RNA-binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: central nervous system development, epithelial cell differentiation, regulation of translation, response to hormone; MF: RNA binding, identical protein binding, mRNA binding, molecular condensate scaffold activity, nucleic acid binding, poly(U) RNA binding, protein homodimerization activity, single-stranded RNA binding; CC: cytoplasm, cytosol, nucleus
Pathways: mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q61474
Entrez ID: 17690
|
Does Knockout of Hes5 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Hes5
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Hes5 (hes family bHLH transcription factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, S-shaped body morphogenesis, animal organ development, anterior/posterior pattern specification, astrocyte differentiation, brain development, camera-type eye development, cartilage development, cell adhesion, cell differentiation, cell maturation, central nervous system myelination, central nervous system neuron differentiation, chondrocyte differentiation, comma-shaped body morphogenesis, establishment of epithelial cell polarity, forebrain radial glial cell differentiation, glial cell fate commitment, inner ear receptor cell stereocilium organization, metanephric nephron tubule morphogenesis, negative regulation of DNA-templated transcription, negative regulation of astrocyte differentiation, negative regulation of cell differentiation, negative regulation of forebrain neuron differentiation, negative regulation of inner ear auditory receptor cell differentiation, negative regulation of inner ear receptor cell differentiation, negative regulation of neuron differentiation, negative regulation of oligodendrocyte differentiation, negative regulation of pro-B cell differentiation, negative regulation of stem cell differentiation, negative regulation of transcription by RNA polymerase II, nervous system development, neural tube development, neuronal stem cell population maintenance, oligodendrocyte development, positive regulation of BMP signaling pathway, positive regulation of DNA-templated transcription, positive regulation of Notch signaling pathway, positive regulation of cell population proliferation, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, protein-containing complex assembly, regulation of DNA-templated transcription, regulation of cell differentiation, regulation of epithelial cell proliferation, regulation of myelination, regulation of neurogenesis, regulation of neuron differentiation, regulation of transcription by RNA polymerase II, smoothened signaling pathway, specification of loop of Henle identity, system development, telencephalon development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, double-stranded DNA binding, protein binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways: Breast cancer - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Notch signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: P70120
Entrez ID: 15208
|
Does Knockout of Ppp3ca in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Ppp3ca
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform)
Type: protein-coding
Summary: Enables calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of transport; and regulation of gene expression. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; calcineurin-NFAT signaling cascade; and regulation of DNA-templated transcription. Located in several cellular components, including Z disc; cytosol; and mitochondrion. Part of calcineurin complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; jaw; and thymus primordium. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G1/S transition of mitotic cell cycle, calcineurin-NFAT signaling cascade, calcineurin-mediated signaling, calcium ion transport, calcium-mediated signaling, cardiac muscle hypertrophy in response to stress, cellular response to glucose stimulus, epidermis development, excitatory postsynaptic potential, keratinocyte differentiation, modulation of chemical synaptic transmission, multicellular organismal response to stress, negative regulation of angiotensin-activated signaling pathway, negative regulation of calcium ion import across plasma membrane, negative regulation of dendrite morphogenesis, negative regulation of gene expression, negative regulation of insulin secretion, negative regulation of signaling, positive regulation of activated T cell proliferation, positive regulation of angiotensin-activated signaling pathway, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of calcium ion import across plasma membrane, positive regulation of calcium ion-dependent exocytosis of neurotransmitter, positive regulation of cardiac muscle hypertrophy, positive regulation of cardiac muscle hypertrophy in response to stress, positive regulation of cell adhesion, positive regulation of cell migration, positive regulation of connective tissue replacement, positive regulation of endocytosis, positive regulation of gene expression, positive regulation of glomerulus development, positive regulation of osteoblast differentiation, positive regulation of osteoclast differentiation, positive regulation of saliva secretion, positive regulation of transcription by RNA polymerase II, postsynaptic modulation of chemical synaptic transmission, proteasome-mediated ubiquitin-dependent protein catabolic process, protein dephosphorylation, protein import into nucleus, regulation of cell proliferation involved in kidney morphogenesis, renal filtration, renal sodium ion absorption, response to calcium ion, skeletal muscle fiber development, transition between fast and slow fiber; MF: ATPase binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding, calmodulin-dependent protein phosphatase activity, enzyme binding, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein dimerization activity, protein serine/threonine phosphatase activity, protein-containing complex binding; CC: Schaffer collateral - CA1 synapse, Z disc, calcineurin complex, cell projection, cytoplasm, cytoplasmic side of plasma membrane, cytosol, dendritic spine, glutamatergic synapse, membrane, mitochondrion, nucleus, plasma membrane, protein serine/threonine phosphatase complex, sarcolemma, slit diaphragm, synapse
Pathways: Adaptive Immune System, Alzheimer disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Axon guidance - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Beta-catenin independent WNT signaling, C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CLEC7A (Dectin-1) induces NFAT activation, CLEC7A (Dectin-1) signaling, Ca2+ pathway, Calcineurin activates NFAT, Calcium signaling pathway - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Downstream signaling events of B Cell Receptor (BCR), FCERI mediated Ca+2 mobilization, Fc epsilon receptor (FCERI) signaling, Glucagon signaling pathway - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Signal Transduction, Signaling by WNT, Signaling by the B Cell Receptor (BCR), T cell receptor signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P63328
Entrez ID: 19055
|
Does Knockout of Rbfox3 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Rbfox3
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Rbfox3 (RNA binding protein, fox-1 homolog (C. elegans) 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, nervous system development, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome; MF: DNA binding, RNA binding, mRNA binding, nucleic acid binding, protein binding; CC: cytoplasm, neuronal cell body, nucleoplasm, nucleus, perikaryon
Pathways:
UniProt: Q8BIF2
Entrez ID: 52897
|
Does Knockout of 3100002H09Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
3100002H09Rik
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: 3100002H09Rik (RIKEN cDNA 3100002H09 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 70249
|
Does Knockout of Exoc5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Exoc5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Exoc5 (exocyst complex component 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, epithelial cell apoptotic process, establishment of planar polarity, exocytosis, homeostasis of number of cells within a tissue, membrane fission, mitotic cytokinesis, morphogenesis of a polarized epithelium, non-motile cilium assembly, protein localization to plasma membrane, protein transport, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; MF: protein binding, small GTPase binding; CC: cytoplasm, cytosol, exocyst, midbody
Pathways: Cargo trafficking to the periciliary membrane, Cilium Assembly, Insulin processing, Metabolism of proteins, Organelle biogenesis and maintenance, Peptide hormone metabolism, Salmonella infection - Mus musculus (mouse), VxPx cargo-targeting to cilium
UniProt: Q3TPX4
Entrez ID: 105504
|
Does Knockout of Rbm43 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Rbm43
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rbm43 (RNA binding motif protein 43)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, molecular_function, nucleic acid binding
Pathways:
UniProt: Q99J64
Entrez ID: 71684
|
Does Knockout of Vmn1r71 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Vmn1r71
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Vmn1r71 (vomeronasal 1 receptor 71)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: A0A2I3BPP6, Q8VIC0
Entrez ID: 252910
|
Does Knockout of Cnot10 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Cnot10
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cnot10 (CCR4-NOT transcription complex, subunit 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA catabolic process, negative regulation of translation, regulation of translation, regulatory ncRNA-mediated gene silencing; CC: CCR4-NOT complex, cytoplasm, cytosol, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Polymerase II Transcription, RNA degradation - Mus musculus (mouse), TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: Q8BH15
Entrez ID: 78893
|
Does Knockout of Atm in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Atm
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Atm (ataxia telangiectasia mutated)
Type: protein-coding
Summary: Enables histone H2AXS139 kinase activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of TORC1 signaling; and regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including immune system development; intracellular signal transduction; and meiotic nuclear division. Located in cytoplasm; microtubule cytoskeleton; and nucleus. Is extrinsic component of synaptic vesicle membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA double-strand break processing, DNA repair, DNA strand resection involved in replication fork processing, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, V(D)J recombination, autophagosome assembly, brain development, cellular response to X-ray, cellular response to gamma radiation, cellular response to ionizing radiation, cellular response to nitrosative stress, cellular response to oxygen-containing compound, cellular response to reactive oxygen species, cellular response to retinoic acid, cellular response to stress, chromatin remodeling, chromosome organization involved in meiotic cell cycle, determination of adult lifespan, double-strand break repair, double-strand break repair via homologous recombination, establishment of RNA localization to telomere, establishment of protein-containing complex localization to telomere, female gamete generation, female gonad development, female meiotic nuclear division, heart development, histone mRNA catabolic process, immune system process, intrinsic apoptotic signaling pathway in response to DNA damage, lipoprotein catabolic process, male meiotic nuclear division, meiosis I, meiotic telomere clustering, mitotic G2 DNA damage checkpoint signaling, mitotic spindle assembly checkpoint signaling, multicellular organism growth, negative regulation of B cell proliferation, negative regulation of TORC1 signaling, negative regulation of double-strand break repair via homologous recombination, negative regulation of signal transduction by p53 class mediator, negative regulation of telomere capping, neuron apoptotic process, oocyte development, ovarian follicle development, pexophagy, phosphatidylinositol-3-phosphate biosynthetic process, positive regulation of DNA catabolic process, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of apoptotic process, positive regulation of autophagosome assembly, positive regulation of cell adhesion, positive regulation of cell migration, positive regulation of double-strand break repair, positive regulation of double-strand break repair via homologous recombination, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of neuron apoptotic process, positive regulation of telomerase catalytic core complex assembly, positive regulation of telomere maintenance via telomerase, positive regulation of telomere maintenance via telomere lengthening, positive regulation of transcription by RNA polymerase II, post-embryonic development, pre-B cell allelic exclusion, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked ubiquitination, protein autophosphorylation, protein localization to site of double-strand break, protein monoubiquitination, protein stabilization, regulation of autophagosome assembly, regulation of autophagy, regulation of cell cycle, regulation of gene expression, regulation of microglial cell activation, regulation of telomere maintenance via telomerase, replicative senescence, response to hypoxia, response to ionizing radiation, response to oxidative stress, response to starvation, signal transduction in response to DNA damage, somitogenesis, telomere maintenance, thymus development; MF: 1-phosphatidylinositol-3-kinase activity, ATP binding, DNA binding, DNA-dependent protein kinase activity, histone H2AXS139 kinase activity, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: DNA repair complex, centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytoplasmic vesicle, cytoskeleton, extrinsic component of synaptic vesicle membrane, nucleolus, nucleoplasm, nucleus, peroxisomal matrix, peroxisome, site of double-strand break, spindle
Pathways: Apoptosis - Mus musculus (mouse), Autodegradation of the E3 ubiquitin ligase COP1, Autophagy, Cell Cycle, Cell Cycle Checkpoints, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), DNA Damage/Telomere Stress Induced Senescence, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, FoxO signaling pathway - Mus musculus (mouse), G1/S DNA Damage Checkpoints, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Macroautophagy, MicroRNAs in cancer - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), Pexophagy, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Selective autophagy, Sensing of DNA Double Strand Breaks, Stabilization of p53, TP53 Regulates Transcription of Caspase Activators and Caspases, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53, Transcriptional misregulation in cancer - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint
UniProt: Q62388
Entrez ID: 11920
|
Does Knockout of Sdhc in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Sdhc
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sdhc (succinate dehydrogenase complex, subunit C, integral membrane protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, tricarboxylic acid cycle; MF: electron transfer activity, heme binding, metal ion binding; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex II (succinate dehydrogenase)
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II, aerobic respiration -- electron donors reaction list
UniProt: Q9CZB0
Entrez ID: 66052
|
Does Knockout of Ap2s1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Ap2s1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ap2s1 (adaptor-related protein complex 2, sigma 1 subunit)
Type: protein-coding
Summary: Predicted to enable clathrin adaptor activity. Predicted to be involved in postsynaptic neurotransmitter receptor internalization and synaptic vesicle endocytosis. Part of AP-2 adaptor complex. Is active in synapse. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: clathrin-dependent endocytosis, endocytosis, intracellular protein transport, postsynaptic neurotransmitter receptor internalization, protein transport, synaptic vesicle endocytosis, vesicle-mediated transport; MF: clathrin adaptor activity, protein binding; CC: AP-2 adaptor complex, clathrin-coated pit, cytoplasmic side of plasma membrane, extrinsic component of presynaptic endocytic zone membrane, glutamatergic synapse, intracellular membrane-bounded organelle, membrane, membrane coat, plasma membrane, postsynapse, presynapse, synapse, synaptic vesicle
Pathways: Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, Huntington disease - Mus musculus (mouse), Immune System, L1CAM interactions, LDL clearance, MHC class II antigen presentation, Membrane Trafficking, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, PCP/CE pathway, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Recycling pathway of L1, Retrograde neurotrophin signalling, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by WNT, Synaptic vesicle cycle - Mus musculus (mouse), Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transmission across Chemical Synapses, Transport of small molecules, VLDLR internalisation and degradation, Vesicle-mediated transport, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, WNT5A-dependent internalization of FZD4
UniProt: P62743
Entrez ID: 232910
|
Does Knockout of Mrpl38 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mrpl38
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrpl38 (mitochondrial ribosomal protein L38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytosol, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q8K2M0
Entrez ID: 60441
|
Does Knockout of Ngb in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Ngb
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ngb (neuroglobin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hydrogen peroxide, cellular response to hypoxia, negative regulation of apoptotic process, neuron projection development, oxygen transport, response to hypoxia; MF: GDP-dissociation inhibitor activity, heme binding, metal ion binding, nitrite reductase activity, oxidoreductase activity, oxygen binding, oxygen carrier activity, protein binding; CC: cytoplasm, cytosol, mitochondrial matrix, mitochondrion, perikaryon
Pathways: Intracellular oxygen transport, Transport of small molecules
UniProt: Q9ER97
Entrez ID: 64242
|
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