prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Zfp383 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Zfp383
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp383 (zinc finger protein 383)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer. Orthologous to human ZNF383 (zinc finger protein 383). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nuclear membrane, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: A0A087WSF1, A0A087WRR7
Entrez ID: 73729
|
Does Knockout of Capn6 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Capn6
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Capn6 (calpain 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule bundle formation, proteolysis, regulation of cytoskeleton organization; MF: calcium-dependent cysteine-type endopeptidase activity, microtubule binding, protein binding; CC: cytoplasm, cytoskeleton, microtubule, perinuclear region of cytoplasm, spindle, spindle microtubule
Pathways: Degradation of the extracellular matrix, Extracellular matrix organization
UniProt: O35646
Entrez ID: 12338
|
Does Knockout of Uimc1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Uimc1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Uimc1 (ubiquitin interaction motif containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, chromatin organization, double-strand break repair, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, negative regulation of DNA-templated transcription, positive regulation of DNA repair, regulation of DNA repair, response to ionizing radiation; MF: DNA binding, K63-linked polyubiquitin modification-dependent protein binding, histone binding, metal ion binding, nuclear retinoid X receptor binding, ubiquitin-modified histone reader activity, zinc ion binding; CC: BRCA1-A complex, nuclear body, nucleoplasm, nucleus, site of double-strand break
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, G2/M DNA damage checkpoint, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Processing of DNA double-strand break ends, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q5U5Q9
Entrez ID: 20184
|
Does Knockout of Lsm1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Lsm1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lsm1 (LSM1 homolog, mRNA degradation associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, deadenylation-dependent decapping of nuclear-transcribed mRNA, histone mRNA catabolic process, mRNA processing, negative regulation of neuron differentiation, nuclear-transcribed mRNA catabolic process, stem cell population maintenance; MF: RNA binding, mRNA binding, pre-mRNA binding, protein binding; CC: Lsm1-7-Pat1 complex, P-body, axon, cytoplasm, dendrite, neuronal cell body, nucleus, ribonucleoprotein complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Mus musculus (mouse), mRNA decay by 5' to 3' exoribonuclease
UniProt: Q8VC85
Entrez ID: 67207
|
Does Knockout of Llgl1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Llgl1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Llgl1 (LLGL1 scribble cell polarity complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, axonogenesis, brain development, cortical actin cytoskeleton organization, establishment of spindle orientation, exocytosis, maintenance of apical/basal cell polarity, nervous system development, protein-containing complex assembly, regulation of Notch signaling pathway, regulation of establishment or maintenance of cell polarity; MF: GTPase activator activity, myosin II binding, protein kinase binding, small GTPase binding; CC: Golgi apparatus, Golgi cis cisterna, Golgi membrane, axon, basolateral plasma membrane, cell projection, cortical actin cytoskeleton, cytoplasm, cytoskeleton, early endosome membrane, endosome, membrane, myelin sheath abaxonal region, plasma membrane, trans-Golgi network membrane
Pathways: Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: Q80Y17
Entrez ID: 16897
|
Does Knockout of Atf6b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Atf6b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Atf6b (activating transcription factor 6 beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum unfolded protein response, mitotic chromosome condensation, negative regulation of ATF6-mediated unfolded protein response, negative regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to unfolded protein; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: RNA polymerase II transcription regulator complex, condensed nuclear chromosome, early endosome, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, microtubule organizing center, nuclear matrix, nucleolus, nucleoplasm, nucleus, protein-DNA complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: A0A0A0MQ69, Q3UJ07, G3UX19, G3UX56, G3UXQ6
Entrez ID: 12915
|
Does Knockout of Wdr82 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Wdr82
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Wdr82 (WD repeat domain containing 82)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription termination, RNA polymerase II promoter clearance, gene expression, lncRNA catabolic process, negative regulation of DNA-templated transcription, elongation, negative regulation of lncRNA transcription, nuclear RNA surveillance, positive regulation of transcription elongation by RNA polymerase II; MF: chromatin binding, lncRNA binding, protein binding; CC: PTW/PP1 phosphatase complex, Set1C/COMPASS complex, chromatin, chromosome, chromosome, telomeric region, cytoplasm, histone methyltransferase complex, nucleolus, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Metabolism of RNA, Nuclear RNA decay, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q8BFQ4
Entrez ID: 77305
|
Does Knockout of Anxa3 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Anxa3
|
response to virus
|
Microglial Cell Line
|
Gene: Anxa3 (annexin A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to bacterium, neutrophil degranulation, phagocytosis, positive regulation of DNA metabolic process, positive regulation of angiogenesis, positive regulation of endothelial cell migration; MF: calcium ion binding, calcium-dependent phospholipid binding, calcium-dependent protein binding, phosphatidylserine binding, phospholipase A2 inhibitor activity, phospholipase inhibitor activity; CC: axon, cytoplasm, dendrite, extracellular matrix, membrane, neuronal cell body, nucleus, phagocytic vesicle membrane, plasma membrane, specific granule, vesicle membrane
Pathways:
UniProt: O35639
Entrez ID: 11745
|
Does Knockout of Washc1 in macrophage causally result in phagocytosis?
| 1
| 1,888
|
Knockout
|
Washc1
|
phagocytosis
|
macrophage
|
Gene: Washc1 (WASH complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, T cell proliferation, dendritic cell antigen processing and presentation, endocytic recycling, endosomal transport, endosome organization, endosome to plasma membrane protein transport, exocytosis, low-density lipoprotein particle clearance, meiotic spindle assembly, negative regulation of autophagy, oocyte maturation, polar body extrusion after meiotic divisions, positive regulation of cholesterol import, positive regulation of protein localization to cell surface, protein localization to cell surface, regulation of Arp2/3 complex-mediated actin nucleation, regulation of actin filament polymerization, regulation of immune response, regulation of protein ubiquitination, retrograde transport, endosome to Golgi; MF: actin binding, alpha-tubulin binding, gamma-tubulin binding, phosphatidylinositol 3-kinase inhibitor activity, ubiquitin protein ligase binding; CC: BLOC-1 complex, WASH complex, autophagosome, centriole, centrosome, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, early endosome, early endosome membrane, endosome, exocyst, filopodium, lamellipodium, late endosome, membrane, recycling endosome, recycling endosome membrane
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q8VDD8
Entrez ID: 68767
|
Does Knockout of Ikbkg in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Ikbkg
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ikbkg (inhibitor of kappaB kinase gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell homeostasis, DNA damage response, anoikis, canonical NF-kappaB signal transduction, defense response to bacterium, establishment of vesicle localization, negative regulation of canonical NF-kappaB signal transduction, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of gene expression, positive regulation of macroautophagy, positive regulation of transcription by RNA polymerase II, protein-containing complex assembly, regulation of transcription by RNA polymerase II, tumor necrosis factor-mediated signaling pathway; MF: K63-linked polyubiquitin modification-dependent protein binding, identical protein binding, linear polyubiquitin binding, metal ion binding, peroxisome proliferator activated receptor binding, polyubiquitin modification-dependent protein binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein homodimerization activity, protein-containing complex binding, signaling adaptor activity, transferrin receptor binding, ubiquitin protein ligase binding, zinc ion binding; CC: IkappaB kinase complex, cytoplasm, cytosol, mitotic spindle, nucleus, protein-containing complex, spindle pole, ubiquitin ligase complex
Pathways: Activation of NF-kappaB in B cells, Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Apoptosis - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytosolic DNA-sensing pathway - Mus musculus (mouse), Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, Death Receptor Signaling, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IKK complex recruitment mediated by RIP1, IL-17 signaling pathway - Mus musculus (mouse), IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Interferon Signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, Modulation of host responses by IFN-stimulated genes, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), NOD1/2 Signaling Pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Osteoclast differentiation - Mus musculus (mouse), Ovarian tumor domain proteases, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PKR-mediated signaling, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Primary immunodeficiency - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), RIP-mediated NFkB activation via ZBP1, Ras signaling pathway - Mus musculus (mouse), Regulation of NF-kappa B signaling, Regulation of TNFR1 signaling, Response of endothelial cells to shear stress, SLC15A4:TASL-dependent IRF5 activation, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of immune response proteins, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Signaling by the B Cell Receptor (BCR), Small cell lung cancer - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TAK1-dependent IKK and NF-kappa-B activation , TCR signaling, TNF signaling, TNF signaling pathway - Mus musculus (mouse), TNFR1-induced NF-kappa-B signaling pathway, TRAF6 mediated NF-kB activation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Ub-specific processing proteases, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), ZBP1(DAI) mediated induction of type I IFNs, activated TAK1 mediates p38 MAPK activation
UniProt: O88522
Entrez ID: 16151
|
Does Knockout of Hmgb3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Hmgb3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hmgb3 (high mobility group box 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA geometric change, immune system process, innate immune response, negative regulation of B cell differentiation, negative regulation of myeloid cell differentiation; MF: DNA binding, DNA binding, bending, RNA binding, four-way junction DNA binding; CC: chromosome, cytoplasm, nucleus
Pathways:
UniProt: O54879
Entrez ID: 15354
|
Does Knockout of Rps27 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Rps27
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rps27 (ribosomal protein S27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, metal ion binding, protein binding, structural constituent of ribosome, zinc ion binding; CC: GABA-ergic synapse, cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, glutamatergic synapse, nucleolus, nucleus, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cap-dependent Translation Initiation, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Coronavirus disease - COVID-19 - Mus musculus (mouse), EML4 and NUDC in mitotic spindle formation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, M Phase, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6ZWU9
Entrez ID: 57294
|
Does Knockout of Enpp5 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Enpp5
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Enpp5 (ectonucleotide pyrophosphatase/phosphodiesterase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell communication, nucleotide catabolic process; MF: NAD+ diphosphatase activity, dinucleotide phosphatase activity, hydrolase activity, metal ion binding, zinc ion binding; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: Q9EQG7
Entrez ID: 83965
|
Does Knockout of Plk3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Plk3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Plk3 (polo like kinase 3)
Type: protein-coding
Summary: This gene encodes a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal catalytic domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases have primarily been implicated in cell cycle regulation. In mouse, this protein that has been reported to localize to the nucleolus during interphase but is undetectable during mitosis, following nucleolus dissociation during prophase. The protein relocalizes to the nucleolus just prior to cytokinesis and peak levels are detected during G1 of interphase. This gene has been implicated in regulation of entry into S phase, with RNAi-induced depletion resulting in failure to re-enter the cell cycle. Mice deficient for this gene exhibit increased weight and tumor development at advanced age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: DNA damage response, G1/S transition of mitotic cell cycle, Golgi disassembly, apoptotic process, cytoplasmic microtubule organization, mitotic G1/S transition checkpoint signaling, mitotic spindle organization, negative regulation of apoptotic process, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of transcription by RNA polymerase II, positive regulation of chaperone-mediated autophagy, positive regulation of intracellular protein transport, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of G1/S transition of mitotic cell cycle, regulation of cell communication, regulation of cell division, regulation of cytokinesis, regulation of signaling, response to osmotic stress, response to radiation, response to reactive oxygen species; MF: ATP binding, kinase activity, nucleotide binding, p53 binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, Golgi stack, centrosome, chromatin, cytoplasm, cytoskeleton, dendrite, kinetochore, neuronal cell body, nucleolus, nucleus, spindle pole
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: F6V5S5, Q6P571
Entrez ID: 12795
|
Does Knockout of Hdac3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Hdac3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hdac3 (histone deacetylase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair-dependent chromatin remodeling, cellular response to fluid shear stress, cellular response to mechanical stimulus, cellular response to parathyroid hormone stimulus, chromatin organization, circadian regulation of gene expression, cornified envelope assembly, epidermis development, epigenetic regulation of gene expression, establishment of mitotic spindle orientation, establishment of skin barrier, gene expression, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of JNK cascade, negative regulation of cardiac muscle cell differentiation, negative regulation of ferroptosis, negative regulation of interleukin-1 production, negative regulation of protein export from nucleus, negative regulation of transcription by RNA polymerase II, negative regulation of tumor necrosis factor production, neural precursor cell proliferation, positive regulation of TOR signaling, positive regulation of cold-induced thermogenesis, positive regulation of ferroptosis, positive regulation of neuron apoptotic process, positive regulation of protein import into nucleus, positive regulation of protein phosphorylation, positive regulation of protein ubiquitination, positive regulation of transcription by RNA polymerase II, positive regulation of type B pancreatic cell apoptotic process, random inactivation of X chromosome, regulation of circadian rhythm, regulation of mitotic cell cycle, regulation of multicellular organism growth, regulation of protein stability, response to dexamethasone, response to nutrient levels, response to xenobiotic stimulus, rhythmic process, spindle assembly; MF: DNA binding, DNA-binding transcription factor binding, GTPase binding, NF-kappaB binding, chromatin DNA binding, chromatin binding, cyclin binding, deacetylase activity, enzyme binding, histone deacetylase activity, histone deacetylase activity, hydrolytic mechanism, histone deacetylase binding, histone decrotonylase activity, hydrolase activity, metal ion binding, protein binding, protein de-2-hydroxyisobutyrylase activity, protein decrotonylase activity, protein lysine deacetylase activity, protein lysine delactylase activity, transcription corepressor activity, transcription corepressor binding, ubiquitin-specific protease binding; CC: Golgi apparatus, chromatin, chromosome, cytoplasm, cytosol, histone deacetylase complex, mitotic spindle, nucleoplasm, nucleus, plasma membrane, transcription repressor complex
Pathways: Adipogenesis, Alcoholism - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Cytoprotection by HMOX1, Developmental Biology, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Neutrophil extracellular trap formation - Mus musculus (mouse), Notch-HLH transcription pathway, RNA Polymerase II Transcription, Regulation of lipid metabolism by PPARalpha, STAT3 nuclear events downstream of ALK signaling, Signal Transduction, Signaling by ALK, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional regulation of white adipocyte differentiation, Viral carcinogenesis - Mus musculus (mouse)
UniProt: O88895
Entrez ID: 15183
|
Does Knockout of Nek2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Nek2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nek2 (NIMA (never in mitosis gene a)-related expressed kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, cell division, centrosome separation, chromosome segregation, meiotic cell cycle, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle assembly, negative regulation of centriole-centriole cohesion, positive regulation of telomere maintenance, regulation of attachment of spindle microtubules to kinetochore, regulation of mitotic centrosome separation, spindle assembly; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein phosphatase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, chromosome, chromosome, centromeric region, ciliary basal body, cilium, condensed chromosome, condensed nuclear chromosome, cytoplasm, cytoskeleton, intercellular bridge, kinetochore, microtubule, microtubule cytoskeleton, midbody, nuclear lumen, nucleolus, nucleoplasm, nucleus, plasma membrane, protein-containing complex, spindle pole
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of mitotic proteins, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AURKA Activation by TPX2, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, Co-inhibition by PD-1, G2/M Transition, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Immune System, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PLK1 Activity at G2/M Transition, Regulation of T cell activation by CD28 family, Regulation of mitotic cell cycle
UniProt: O35942
Entrez ID: 18005
|
Does Knockout of Bphl in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Bphl
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Bphl (biphenyl hydrolase like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: homocysteine metabolic process, xenobiotic metabolic process; MF: alpha-amino-acid esterase activity, hydrolase activity, metal ion binding, serine hydrolase activity; CC: mitochondrion
Pathways: Biological oxidations, Metabolism, Phase I - Functionalization of compounds
UniProt: Q8R164
Entrez ID: 68021
|
Does Knockout of Utp11 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Utp11
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Utp11 (UTP11 small subunit processome component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development, positive regulation of apoptotic process, rRNA processing, ribosomal small subunit biogenesis; CC: cytoplasm, cytosol, extracellular space, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CZJ1
Entrez ID: 67205
|
Does Knockout of Dbt in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Dbt
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Dbt (dihydrolipoamide branched chain transacylase E2)
Type: protein-coding
Summary: Predicted to enable acetyltransferase activity; lipoic acid binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to branched-chain alpha-keto acid dehydrogenase activity. Predicted to be involved in branched-chain amino acid catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; integumental system; sensory organ; and urinary system. Used to study maple syrup urine disease. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DBT (dihydrolipoamide branched chain transacylase E2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA, branched-chain amino acid catabolic process; MF: acyltransferase activity, dihydrolipoamide branched chain acyltransferase activity, transferase activity, ubiquitin protein ligase binding; CC: branched-chain alpha-ketoacid dehydrogenase complex, cytosol, microtubule cytoskeleton, mitochondrial matrix, mitochondrial nucleoid, mitochondrion
Pathways: BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV, Branched-chain amino acid catabolism, Leucine Catabolism, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Mitochondrial protein degradation, Post-translational protein modification, Propanoate metabolism - Mus musculus (mouse), Protein lipoylation, RHO GTPase cycle, RHOH GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Valine, leucine and isoleucine degradation - Mus musculus (mouse), branched-chain α-keto acid dehydrogenase complex, isoleucine degradation, valine degradation
UniProt: P53395
Entrez ID: 13171
|
Does Knockout of Apol7b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Apol7b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Apol7b (apolipoprotein L 7b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid transport, lipoprotein metabolic process; MF: chloride channel activity, lipid binding; CC: extracellular region, extracellular space, high-density lipoprotein particle, very-low-density lipoprotein particle
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Scavenging of heme from plasma, Vesicle-mediated transport
UniProt: A0A2R8VHA9, B1AQP7
Entrez ID: 278679
|
Does Knockout of Larp4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Larp4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Larp4 (La ribonucleoprotein 4)
Type: protein-coding
Summary: Predicted to enable mRNA 3'-UTR binding activity and poly(A) binding activity. Predicted to be involved in cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human LARP4 (La ribonucleoprotein 4). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cytoskeleton organization, positive regulation of translation, post-transcriptional regulation of gene expression, regulation of cell morphogenesis, translation; MF: RNA binding, mRNA 3'-UTR binding, nucleic acid binding, poly(A) binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, cytosolic small ribosomal subunit
Pathways:
UniProt: Q8BWW4
Entrez ID: 207214
|
Does Knockout of Mrgpra3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Mrgpra3
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mrgpra3 (MAS-related GPR, member A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, acute-phase response, cell surface receptor signaling pathway, chemosensory behavior, response to chloroquine, signal transduction; MF: G protein-coupled receptor activity, neuropeptide binding, transmembrane signaling receptor activity; CC: axon, membrane, neuronal cell body membrane, plasma membrane
Pathways:
UniProt: Q91WW3
Entrez ID: 233222
|
Does Knockout of Atp13a2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Atp13a2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Atp13a2 (ATPase type 13A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome organization, autophagosome-lysosome fusion, autophagy, cellular response to manganese ion, cellular response to oxidative stress, extracellular exosome biogenesis, intracellular calcium ion homeostasis, intracellular iron ion homeostasis, intracellular zinc ion homeostasis, lipid homeostasis, lysosomal transport, monoatomic cation transmembrane transport, polyamine transmembrane transport, positive regulation of exosomal secretion, positive regulation of gene expression, positive regulation of protein secretion, protein localization to lysosome, regulation of autophagosome size, regulation of intracellular protein transport, regulation of lysosomal protein catabolic process, regulation of macroautophagy, regulation of mitochondrion organization, regulation of protein localization to nucleus, spermine transmembrane transport; MF: ABC-type polyamine transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled monoatomic cation transmembrane transporter activity, P-type ion transporter activity, P-type transmembrane transporter activity, metal ion binding, nucleotide binding, phosphatidic acid binding, phosphatidylinositol-3,5-bisphosphate binding, polyamine transmembrane transporter activity; CC: autophagosome, autophagosome membrane, cytoplasmic vesicle, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, multivesicular body, multivesicular body membrane, neuron projection, neuronal cell body, transport vesicle, vesicle, vesicle membrane
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: Q9CTG6
Entrez ID: 74772
|
Does Knockout of Gsdmcl1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gsdmcl1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gsdmcl1 (gasdermin C-like 1)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Snu13 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Snu13
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Snu13 (SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, box C/D snoRNP assembly, mRNA processing, mRNA splicing, via spliceosome, maturation of SSU-rRNA, ribosomal small subunit biogenesis, ribosome biogenesis, single fertilization; MF: ATPase binding, RNA binding, U3 snoRNA binding, U4 snRNA binding, U4atac snRNA binding, box C/D sno(s)RNA binding, snoRNA binding; CC: U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U4atac snRNP, box C/D methylation guide snoRNP complex, dense fibrillar component, nucleolus, nucleus, plasma membrane, precatalytic spliceosome, protein-containing complex, ribonucleoprotein complex, small-subunit processome, spliceosomal complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D0T1
Entrez ID: 20826
|
Does Knockout of Polr2m in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Polr2m
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Polr2m (polymerase (RNA) II (DNA directed) polypeptide M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of ER location, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, molecular_function, transcription elongation factor activity; CC: DNA-directed RNA polymerase complex, I band, RNA polymerase II, core complex, neuronal cell body, nuclear envelope, nucleus, transcription preinitiation complex
Pathways:
UniProt: Q6P6I6
Entrez ID: 28015
|
Does Knockout of Mettl16 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mettl16
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mettl16 (methyltransferase 16, N6-methyladenosine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, RNA modification, S-adenosylmethionine biosynthetic process, mRNA catabolic process, mRNA destabilization, mRNA processing, methylation, negative regulation of 3'-UTR-mediated mRNA stabilization, positive regulation of mRNA catabolic process, post-transcriptional regulation of gene expression, rRNA base methylation, regulation of mRNA splicing, via spliceosome, regulation of mRNA stability, snRNA (adenine-N6)-methylation; MF: RNA binding, RNA stem-loop binding, U6 snRNA (adenine-(43)-N(6))-methyltransferase activity, U6 snRNA 3'-end binding, mRNA m(6)A methyltransferase activity, methyltransferase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9CQG2
Entrez ID: 67493
|
Does Knockout of Ubc in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Ubc
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ubc (ubiquitin C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: modification-dependent protein catabolic process, protein ubiquitination; MF: protein binding, protein tag activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, membrane, mitochondrial outer membrane, mitochondrion, myelin sheath, nucleoplasm, nucleus
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activated NOTCH1 Transmits Signal to the Nucleus, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Aerobic respiration and respiratory electron transport, Aggrephagy, Alpha-protein kinase 1 signaling pathway, Antigen processing: Ubiquitination & Proteasome degradation, Asparagine N-linked glycosylation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Autophagy, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Calnexin/calreticulin cycle, Cargo recognition for clathrin-mediated endocytosis, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell death signalling via NRAGE, NRIF and NADE, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Clathrin-mediated endocytosis, Co-inhibition by PD-1, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, Deactivation of the beta-catenin transactivating complex, Death Receptor Signaling, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Downregulation of ERBB2 signaling, Downregulation of ERBB2:ERBB3 signaling, Downregulation of ERBB4 signaling, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Downregulation of TGF-beta receptor signaling, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, EGFR downregulation, ER Quality Control Compartment (ERQC), Endosomal Sorting Complex Required For Transport (ESCRT), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, FLT3 Signaling, Fanconi Anemia Pathway, Fc epsilon receptor (FCERI) signaling, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, G1 Phase, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Homology Directed Repair, IKK complex recruitment mediated by RIP1, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, IRAK2 mediated activation of TAK1 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, Immune System, Inactivation of CSF3 (G-CSF) signaling, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, Ion channel transport, Iron uptake and transport, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Josephin domain DUBs, KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), M Phase, MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Macroautophagy, Membrane Trafficking, Metabolism, Metabolism of RNA, Metabolism of proteins, Metalloprotease DUBs, Mitophagy, Mitophagy - animal - Mus musculus (mouse), Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, NF-kB is activated and signals survival, NIK-->noncanonical NF-kB signaling, NOD1/2 Signaling Pathway, NOTCH3 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Neddylation, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of FLT3, Negative regulation of MAPK pathway, Negative regulation of MET activity, Negative regulators of DDX58/IFIH1 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Nucleotide Excision Repair, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oncogene Induced Senescence, Orc1 removal from chromatin, Ovarian tumor domain proteases, Oxidative Stress Induced Senescence, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PD-L1(CD274) glycosylation and translocation to plasma membrane, PINK1-PRKN Mediated Mitophagy, PIP3 activates AKT signaling, PPAR signaling pathway - Mus musculus (mouse), PTEN Regulation, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Peroxisomal protein import, Pexophagy, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Post-translational protein modification, Processing of DNA double-strand break ends, Programmed Cell Death, Protein localization, Protein ubiquitination, Pyruvate metabolism, RAF/MAP kinase cascade, RAS processing, RIPK1-mediated regulated necrosis, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Recognition of DNA damage by PCNA-containing replication complex, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulated Necrosis, Regulation of APC/C activators between G1/S and early anaphase, Regulation of BACH1 activity, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of FZD by ubiquitination, Regulation of Homotypic Cell-Cell Adhesion, Regulation of NF-kappa B signaling, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PLK1 Activity at G2/M Transition, Regulation of PTEN localization, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TNFR1 signaling, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of expression of SLITs and ROBOs, Regulation of innate immune responses to cytosolic DNA, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of necroptotic cell death, Regulation of pyruvate metabolism, Regulation of signaling by CBL, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, SPOP-mediated proteasomal degradation of PD-L1(CD274), Selective autophagy, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Hedgehog, Signaling by Interleukins, Signaling by MET, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH3, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spry regulation of FGF signaling, Stabilization of p53, Stimuli-sensing channels, Switching of origins to a post-replicative state, Synthesis of DNA, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, TAK1-dependent IKK and NF-kappa-B activation , TCF dependent signaling in response to WNT, TCR signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR2 non-canonical NF-kB pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , Termination of translesion DNA synthesis, The role of GTSE1 in G2/M progression after G2 checkpoint, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Mus musculus (mouse), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, VLDLR internalisation and degradation, Vesicle-mediated transport, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, activated TAK1 mediates p38 MAPK activation, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, p75 NTR receptor-mediated signalling, p75NTR recruits signalling complexes, p75NTR signals via NF-kB
UniProt: P0CG50
Entrez ID: 22190
|
Does Knockout of Elmod1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Elmod1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Elmod1 (ELMO/CED-12 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, intracellular protein localization, protein transport; MF: GTPase activator activity; CC: Golgi apparatus, cilium, glutamatergic synapse, synapse
Pathways:
UniProt: Q3V1U8
Entrez ID: 270162
|
Does Knockout of Ccnd1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Ccnd1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ccnd1 (cyclin D1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, G1/S transition of mitotic cell cycle, Leydig cell differentiation, Wnt signaling pathway, animal organ regeneration, cell division, cell population proliferation, cellular response to hypoxia, endoplasmic reticulum unfolded protein response, fat cell differentiation, lactation, liver development, liver regeneration, mammary gland alveolus development, mammary gland epithelial cell proliferation, mitotic G1 DNA damage checkpoint signaling, negative regulation of epithelial cell differentiation, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, neuron differentiation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of mammary gland epithelial cell proliferation, re-entry into mitotic cell cycle, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, response to UV-A, response to X-ray, response to calcium ion, response to corticosterone, response to estradiol, response to estrogen, response to ethanol, response to glucocorticoid, response to iron ion, response to leptin, response to magnesium ion, response to steroid hormone, response to vitamin E, response to xenobiotic stimulus; MF: cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase regulator activity, enzyme binding, histone deacetylase binding, kinase activity, proline-rich region binding, protein binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activator activity, protein-containing complex binding, transcription corepressor activity; CC: bicellular tight junction, cyclin D1-CDK4 complex, cyclin D1-CDK6 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, membrane, microtubule organizing center, nuclear membrane, nucleoplasm, nucleus, transcription repressor complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Alcoholic liver disease - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chromatin modifying enzymes, Chromatin organization, Chronic myeloid leukemia - Mus musculus (mouse), Co-inhibition by PD-1, Colorectal cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Drug-mediated inhibition of CDK4/CDK6 activity, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G1 Phase, G1/S Transition, Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glioma - Mus musculus (mouse), Hedgehog signaling pathway - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Non-small cell lung cancer - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PTK6 Regulates Cell Cycle, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX3 regulates p14-ARF, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of RUNX1 Expression and Activity, Regulation of T cell activation by CD28 family, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Small cell lung cancer - Mus musculus (mouse), Thyroid cancer - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Ubiquitin-dependent degradation of Cyclin D, Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P25322
Entrez ID: 12443
|
Does Knockout of Dda1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Dda1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dda1 (DET1 and DDB1 associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of proteasomal ubiquitin-dependent protein catabolic process; CC: Cul4-RING E3 ubiquitin ligase complex
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9D9Z5
Entrez ID: 66498
|
Does Knockout of Sf3a1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Sf3a1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sf3a1 (splicing factor 3a, subunit 1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP and spliceosomal complex. Is expressed in central nervous system and sensory organ. Orthologous to human SF3A1 (splicing factor 3a subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA processing, RNA splicing, U2-type prespliceosome assembly, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: U2 snRNP, U2-type precatalytic spliceosome, U2-type prespliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8K4Z5
Entrez ID: 67465
|
Does Knockout of Sart3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Sart3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Sart3 (squamous cell carcinoma antigen recognized by T cells 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, cell morphogenesis, hematopoietic stem cell proliferation, homeostasis of number of cells, mRNA processing, mRNA splicing, via spliceosome, nucleosome assembly, regulation of RNA metabolic process, regulation of gene expression, spliceosomal snRNP assembly, spliceosomal tri-snRNP complex assembly, transcription elongation-coupled chromatin remodeling; MF: RNA binding, U4 snRNA binding, U6 snRNA binding, U6atac snRNA binding, histone binding, nucleic acid binding, protein-macromolecule adaptor activity, ubiquitin-specific protease binding; CC: ASAP complex, Cajal body, U4/U6 snRNP, U6atac snRNP, cytoplasm, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q9JLI8
Entrez ID: 53890
|
Does Knockout of Zfp119a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Zfp119a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp119a (zinc finger protein 119a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q9JIC0
Entrez ID: 104349
|
Does Knockout of Zfp157 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Zfp157
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp157 (zinc finger protein 157)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial cell fate commitment, lung alveolus development, mammary gland morphogenesis, regulation of DNA-templated transcription, regulation of cell fate commitment, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: D3Z0U7, Q6PCM4, D3YYT4
Entrez ID: 72154
|
Does Knockout of Lrfn2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Lrfn2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lrfn2 (leucine rich repeat and fibronectin type III domain containing 2)
Type: protein-coding
Summary: Involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Located in cell surface. Is active in Schaffer collateral - CA1 synapse; postsynapse; and presynapse. Is expressed in several structures, including central nervous system; esophagus; eye; male reproductive gland or organ; and trigeminal nerve. Used to study autism spectrum disorder. Orthologous to human LRFN2 (leucine rich repeat and fibronectin type III domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: modulation of chemical synaptic transmission, regulation of postsynapse organization; CC: Schaffer collateral - CA1 synapse, cell surface, membrane, plasma membrane, postsynapse, postsynaptic density membrane, postsynaptic membrane, presynapse, synapse
Pathways: Neuronal System, Protein-protein interactions at synapses, Synaptic adhesion-like molecules
UniProt: Q80TG9
Entrez ID: 70530
|
Does Knockout of Ndufa2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Ndufa2
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Ndufa2 (NADH:ubiquinone oxidoreductase subunit A2)
Type: protein-coding
Summary: This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. The human ortholog of this gene has been characterized, and its structure and redox potential is reported to be similar to that of thioredoxins. It may be involved in regulating complex I activity or assembly via assistance in redox processes. In humans, mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. A pseudogene of this gene is located on chromosome 5. [provided by RefSeq, May 2013].
Gene Ontology: BP: aerobic respiration, blastocyst hatching, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQ75
Entrez ID: 17991
|
Does Knockout of Krtap7-1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Krtap7-1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Krtap7-1 (keratin associated protein 7-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, intermediate filament
Pathways:
UniProt: Q9D3I6
Entrez ID: 71363
|
Does Knockout of Ercc4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ercc4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ercc4 (excision repair cross-complementing rodent repair deficiency, complementation group 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, UV protection, cellular response to UV, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, negative regulation of protection from non-homologous end joining at telomere, negative regulation of telomere maintenance, negative regulation of telomere maintenance via telomere lengthening, nucleotide-excision repair, nucleotide-excision repair involved in interstrand cross-link repair, regulation of autophagy, resolution of meiotic recombination intermediates, response to UV, telomere maintenance, telomeric DNA-containing double minutes formation; MF: 3' overhang single-stranded DNA endodeoxyribonuclease activity, DNA binding, DNA endonuclease activity, TFIID-class transcription factor complex binding, damaged DNA binding, endonuclease activity, hydrolase activity, identical protein binding, nuclease activity, promoter-specific chromatin binding, single-stranded DNA binding, single-stranded DNA endodeoxyribonuclease activity; CC: ERCC4-ERCC1 complex, chromosome, chromosome, telomeric region, nucleotide-excision repair complex, nucleotide-excision repair factor 1 complex, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Formation of Incision Complex in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Transcription-Coupled Nucleotide Excision Repair (TC-NER)
UniProt: Q9QZD4
Entrez ID: 50505
|
Does Knockout of Mocs3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Mocs3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Mocs3 (molybdenum cofactor synthesis 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Mo-molybdopterin cofactor biosynthetic process, molybdopterin cofactor biosynthetic process, protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification; MF: ATP binding, URM1 activating enzyme activity, adenylyltransferase activity, catalytic activity, metal ion binding, molybdopterin-synthase adenylyltransferase activity, molybdopterin-synthase sulfurtransferase activity, nucleotide binding, nucleotidyltransferase activity, sulfurtransferase activity, thiosulfate-cyanide sulfurtransferase activity, transferase activity, ubiquitin-like modifier activating enzyme activity; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Molybdenum cofactor biosynthesis, Sulfur relay system - Mus musculus (mouse)
UniProt: A2BDX3
Entrez ID: 69372
|
Does Knockout of Hjurp in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Hjurp
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Hjurp (Holliday junction recognition protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CENP-A containing chromatin assembly, chromosome segregation, regulation of protein-containing complex assembly; MF: DNA binding, histone binding, identical protein binding; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, nucleolus, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, Cyclin A/B1/B2 associated events during G2/M transition, Deposition of new CENPA-containing nucleosomes at the centromere, G2/M Transition, Mitotic G2-G2/M phases, Nucleosome assembly
UniProt: Q6PG16
Entrez ID: 381280
|
Does Knockout of Toe1 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Toe1
|
response to virus
|
Microglial Cell Line
|
Gene: Toe1 (target of EGR1, member 1 (nuclear))
Type: protein-coding
Summary: Predicted to enable poly(A)-specific ribonuclease activity and snRNA binding activity. Predicted to be involved in snRNA 3'-end processing. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in Cajal body. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 7. Orthologous to human TOE1 (target of EGR1, exonuclease). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA metabolic process, snRNA 3'-end processing; MF: 3'-5'-RNA exonuclease activity, metal ion binding, nucleic acid binding, poly(A)-specific ribonuclease activity, snRNA binding, zinc ion binding; CC: Cajal body, cytoplasm, nuclear body, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9D2E2
Entrez ID: 68276
|
Does Knockout of Rprd1b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Rprd1b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rprd1b (regulation of nuclear pre-mRNA domain containing 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, mRNA 3'-end processing, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, regulation of cell cycle process; MF: RNA polymerase II C-terminal domain binding, RNA polymerase II complex binding, identical protein binding; CC: nucleoplasm, nucleus, transcription preinitiation complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q9CSU0
Entrez ID: 70470
|
Does Knockout of Rufy3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Rufy3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rufy3 (RUN and FYVE domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, cell differentiation, negative regulation of axonogenesis, nervous system development, positive regulation of axon extension, positive regulation of axonogenesis, positive regulation of cell migration, positive regulation of intracellular protein transport, positive regulation of retrograde axon cargo transport, regulation of axonogenesis, regulation of establishment of cell polarity; MF: dynactin binding, protein binding; CC: anchoring junction, axon, cell projection, cytoplasm, cytosol, dendrite, endolysosome, endomembrane system, filopodium, growth cone, lamellipodium, lysosome, membrane, neuronal cell body, perikaryon
Pathways:
UniProt: Q9D394
Entrez ID: 52822
|
Does Knockout of Nckap1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Nckap1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nckap1 (NCK-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, apical protein localization, basal protein localization, cell migration, cell migration involved in gastrulation, cell morphogenesis, cell projection assembly, cortical actin cytoskeleton organization, embryonic body morphogenesis, embryonic foregut morphogenesis, embryonic heart tube development, endoderm development, establishment or maintenance of actin cytoskeleton polarity, in utero embryonic development, lamellipodium assembly, mesodermal cell migration, neural tube closure, neuron projection morphogenesis, notochord development, notochord morphogenesis, paraxial mesoderm development, paraxial mesoderm morphogenesis, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of actin filament polymerization, positive regulation of lamellipodium assembly, protein stabilization, regulation of protein localization, somitogenesis, zygotic determination of anterior/posterior axis, embryo; MF: protein binding, small GTPase binding; CC: SCAR complex, cell projection, cytoplasm, filamentous actin, glutamatergic synapse, lamellipodium, lamellipodium membrane, membrane, plasma membrane, postsynapse, postsynaptic density, ruffle
Pathways: Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: P28660
Entrez ID: 50884
|
Does Knockout of Med26 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Med26
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Med26 (mediator complex subunit 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of gene expression, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: protein binding, transcription coregulator activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus
Pathways:
UniProt: Q7TN02
Entrez ID: 70625
|
Does Knockout of Sod1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Sod1
|
phagocytosis
|
macrophage
|
Gene: Sod1 (superoxide dismutase 1, soluble)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential initiation, anterograde axonal transport, auditory receptor cell stereocilium organization, cellular response to ATP, cellular response to cadmium ion, cellular response to oxidative stress, cellular response to potassium ion, determination of adult lifespan, ectopic germ cell programmed cell death, embryo implantation, gene expression, glutathione metabolic process, heart contraction, hydrogen peroxide biosynthetic process, intracellular iron ion homeostasis, locomotory behavior, muscle cell cellular homeostasis, myeloid cell homeostasis, negative regulation of apoptotic process, negative regulation of developmental process, negative regulation of inflammatory response, negative regulation of neuron apoptotic process, negative regulation of reproductive process, neurofilament cytoskeleton organization, neuronal action potential, ovarian follicle development, peripheral nervous system myelin maintenance, positive regulation of MAPK cascade, positive regulation of cytokine production, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of phagocytosis, positive regulation of superoxide anion generation, reactive oxygen species metabolic process, regulation of blood pressure, regulation of mitochondrial membrane potential, regulation of multicellular organism growth, relaxation of vascular associated smooth muscle, removal of superoxide radicals, response to amphetamine, response to antipsychotic drug, response to axon injury, response to carbon monoxide, response to copper ion, response to ethanol, response to heat, response to hydrogen peroxide, response to nutrient levels, response to oxidative stress, response to reactive oxygen species, response to superoxide, response to xenobiotic stimulus, retina homeostasis, retrograde axonal transport, sensory perception of sound, spermatogenesis, superoxide anion generation, superoxide metabolic process, transmission of nerve impulse; MF: antioxidant activity, copper ion binding, enzyme binding, identical protein binding, metal ion binding, oxidoreductase activity, protein binding, protein homodimerization activity, protein phosphatase 2B binding, protein-folding chaperone binding, small GTPase binding, superoxide dismutase activity, zinc ion binding; CC: axon cytoplasm, cytoplasm, cytoplasmic vesicle, cytosol, dendrite cytoplasm, dense core granule, extracellular region, extracellular space, lysosome, mitochondrial intermembrane space, mitochondrion, myelin sheath, neuronal cell body, nucleoplasm, nucleus, peroxisome, plasma membrane, protein-containing complex, secretory granule
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Detoxification of Reactive Oxygen Species, Hemostasis, Huntington disease - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Peroxisome - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , Prion disease - Mus musculus (mouse), Response to elevated platelet cytosolic Ca2+, superoxide radicals degradation
UniProt: P08228
Entrez ID: 20655
|
Does Knockout of Tat in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Tat
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tat (tyrosine aminotransferase)
Type: protein-coding
Summary: This gene encodes a liver-specific mitochondrial enzyme that catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Regulated by glucocorticoid and polypeptide hormones, this gene's expression is affected by deletion of a regulatory region near the albino locus on chromosome 7. Mutations in this gene cause tyrosinemia type II in humans. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: 2-oxoglutarate metabolic process, L-phenylalanine catabolic process, L-tyrosine catabolic process, amino acid metabolic process, aromatic amino acid family catabolic process, aromatic amino acid metabolic process, cellular response to insulin stimulus, cellular response to retinoic acid, glutamate metabolic process, liver regeneration, response to cAMP, response to cortisol, response to dexamethasone, response to ethanol, response to glucocorticoid, response to mercury ion, response to oxidative stress; MF: L-tyrosine-2-oxoglutarate transaminase activity, amino acid binding, catalytic activity, identical protein binding, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: cytosol, mitochondrion
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Phenylalanine and tyrosine metabolism, Phenylalanine metabolism - Mus musculus (mouse), Phenylalanine, tyrosine and tryptophan biosynthesis - Mus musculus (mouse), Tyrosine catabolism, Tyrosine metabolism - Mus musculus (mouse), Ubiquinone and other terpenoid-quinone biosynthesis - Mus musculus (mouse), phenylalanine degradation III, tyrosine degradation I
UniProt: Q8QZR1
Entrez ID: 234724
|
Does Knockout of Snapc5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Snapc5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Snapc5 (small nuclear RNA activating complex, polypeptide 5)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II general transcription initiation factor activity and RNA polymerase III general transcription initiation factor activity. Predicted to be involved in snRNA transcription by RNA polymerase II; snRNA transcription by RNA polymerase III; and transcription initiation at RNA polymerase III promoter. Predicted to be located in nuclear body and nucleolus. Is expressed in genitourinary system. Orthologous to human SNAPC5 (small nuclear RNA activating complex polypeptide 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III, transcription by RNA polymerase II, transcription initiation at RNA polymerase III promoter; MF: RNA polymerase II general transcription initiation factor activity, RNA polymerase III general transcription initiation factor activity; CC: nuclear body, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes
UniProt: Q8R2K7
Entrez ID: 330959
|
Does Knockout of Edc3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Edc3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Edc3 (enhancer of mRNA decapping 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P-body assembly, deadenylation-independent decapping of nuclear-transcribed mRNA; MF: RNA binding, identical protein binding, mRNA binding; CC: P-body, cytoplasm, cytoplasmic ribonucleoprotein granule
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Mus musculus (mouse), mRNA decay by 5' to 3' exoribonuclease
UniProt: Q8K2D3
Entrez ID: 353190
|
Does Knockout of Retn in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Retn
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Retn (resistin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fat cell differentiation, negative regulation of feeding behavior, positive regulation of collagen metabolic process, positive regulation of progesterone secretion, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of synaptic transmission, response to insulin, signal transduction; CC: extracellular region, extracellular space
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q99P87
Entrez ID: 57264
|
Does Knockout of Rps10 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Rps10
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rps10 (ribosomal protein S10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, ribosomal small subunit assembly, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome, tRNA binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P63325
Entrez ID: 67097
|
Does Knockout of Sbno1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Sbno1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Sbno1 (strawberry notch 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, inflammatory response, negative regulation of MAPK cascade, negative regulation of canonical NF-kappaB signal transduction, negative regulation of neuroinflammatory response, positive regulation of canonical Wnt signaling pathway, positive regulation of neural precursor cell proliferation, positive regulation of signal transduction, regulation of DNA-templated transcription; MF: chromatin DNA binding, histone binding; CC: nucleus
Pathways:
UniProt: F7CVW0, B2RRI2, Q3TMM7, A0A0G2JF11, A0A0G2JGC7, A0A0G2JEM3, A0A0G2JG63, A0A0G2JFU7, A0A0G2JDL6, A0A0G2JGI0
Entrez ID: 243272
|
Does Knockout of Scml2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Scml2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Scml2 (Scm polycomb group protein like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, intracellular protein localization, negative regulation of DNA-templated transcription, protein localization to chromosome, regulation of DNA-templated transcription; MF: chromatin binding, histone binding, protein binding; CC: PcG protein complex, XY body, chromatin, nucleus
Pathways:
UniProt: B1AVB4, I6L9E4, B1AVB5, Q8BYC8, B1AVB2, B1AVB1, A0A571BGE2, B1AVB3, A0A571BDL9, E9Q796
Entrez ID: 107815
|
Does Knockout of Ctnnbip1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Ctnnbip1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ctnnbip1 (catenin beta interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, anterior/posterior pattern specification, branching involved in ureteric bud morphogenesis, canonical Wnt signaling pathway, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cell population proliferation, negative regulation of mesenchymal cell proliferation, negative regulation of protein-containing complex assembly, negative regulation of smooth muscle cell proliferation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription initiation by RNA polymerase II, positive regulation of monocyte differentiation, positive regulation of osteoblast differentiation, regulation of vascular permeability involved in acute inflammatory response; MF: armadillo repeat domain binding, beta-catenin binding, protein binding, transcription coactivator binding, transcription regulator inhibitor activity; CC: beta-catenin destruction complex, beta-catenin-ICAT complex, cytoplasm, cytosol, nucleus, protein-containing complex
Pathways: Deactivation of the beta-catenin transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q9JJN6
Entrez ID: 67087
|
Does Knockout of Wdhd1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Wdhd1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Wdhd1 (WD repeat and HMG-box DNA binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, DNA-templated DNA replication, RNA processing, mitotic cell cycle, pericentric heterochromatin organization, regulation of chromosome organization; MF: DNA binding, RNA binding, RNA polymerase binding, chromatin binding, nucleic acid binding, protein binding; CC: chromosome, centromeric region, nuclear replication fork, nucleoplasm, nucleus
Pathways:
UniProt: P59328
Entrez ID: 218973
|
Does Knockout of Laptm4b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Laptm4b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Laptm4b (lysosomal-associated protein transmembrane 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome organization, endosome transport via multivesicular body sorting pathway, negative regulation of lysosomal protein catabolic process, negative regulation of transforming growth factor beta1 production, regulation of lysosomal membrane permeability, regulation of lysosome organization; MF: ceramide binding, kinase binding, phosphatidylinositol bisphosphate binding, ubiquitin protein ligase binding; CC: cell projection, early endosome, endomembrane system, endosome, endosome membrane, late endosome membrane, lysosomal membrane, lysosome, membrane, multivesicular body membrane, multivesicular body, internal vesicle, plasma membrane
Pathways: Lysosome - Mus musculus (mouse)
UniProt: Q91XQ6
Entrez ID: 114128
|
Does Knockout of Rab4a in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 1
| 1,522
|
Knockout
|
Rab4a
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Rab4a (RAB4A, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rab protein signal transduction, antigen processing and presentation, neurotransmitter receptor transport postsynaptic membrane to endosome, protein transport, regulation of endocytosis, small GTPase-mediated signal transduction, vesicle-mediated transport, vesicle-mediated transport in synapse; MF: ATPase activator activity, ATPase binding, G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, ionotropic glutamate receptor binding, metal ion binding, nucleotide binding, protein binding, syntaxin binding; CC: cytoplasm, cytoplasmic vesicle membrane, early endosome membrane, endosome, extracellular exosome, glutamatergic synapse, insulin-responsive compartment, membrane, perinuclear region of cytoplasm, recycling endosome, recycling endosome membrane, synaptic vesicle membrane, vesicle
Pathways: Endocytosis - Mus musculus (mouse), MET receptor recycling, Membrane Trafficking, Metabolism, Metabolism of lipids, Metabolism of proteins, PI Metabolism, Phospholipid metabolism, Post-translational protein modification, RAB geranylgeranylation, Rab regulation of trafficking, Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Synthesis of PIPs at the plasma membrane, TBC/RABGAPs, Vesicle-mediated transport
UniProt: P56371
Entrez ID: 19341
|
Does Knockout of Ddx51 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Ddx51
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Ddx51 (DEAD box helicase 51)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleus
Pathways:
UniProt: Q6P9R1
Entrez ID: 69663
|
Does Knockout of Ifna15 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Ifna15
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Ifna15 (interferon alpha 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways: Alcoholic liver disease - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Cytosolic DNA-sensing pathway - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of IFNA/IFNB signaling, Toll-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q61718
Entrez ID: 242517
|
Does Knockout of Psmd3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Psmd3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Psmd3 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of protein catabolic process, ubiquitin-dependent protein catabolic process; MF: enzyme regulator activity, protein binding; CC: cytosol, nucleoplasm, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P14685
Entrez ID: 22123
|
Does Knockout of Spc24 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Spc24
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Spc24 (SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, mitotic spindle assembly checkpoint signaling; CC: Ndc80 complex, chromosome, chromosome, centromeric region, kinetochore, nucleolus, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9D083
Entrez ID: 67629
|
Does Knockout of Gosr1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Gosr1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Gosr1 (golgi SNAP receptor complex member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, inter-Golgi cisterna vesicle-mediated transport, protein transport, retrograde transport, endosome to Golgi, vesicle fusion, vesicle-mediated transport; MF: SNAP receptor activity; CC: Golgi apparatus, Golgi medial cisterna, Golgi membrane, SNARE complex, cis-Golgi network, membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O88630
Entrez ID: 53334
|
Does Knockout of St3gal3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
St3gal3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: St3gal3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ganglioside biosynthetic process via lactosylceramide, protein glycosylation; MF: N-acetyllactosaminide alpha-2,3-sialyltransferase activity, beta-galactoside (CMP) alpha-2,3-sialyltransferase activity, glycosyltransferase activity, sialyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Blood group systems biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate - Mus musculus (mouse), Glycosaminoglycan metabolism, Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Glycosphingolipid metabolism, Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Lewis blood group biosynthesis, Mannose type O-glycan biosynthesis - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of lipids, Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Sialic acid metabolism, Sphingolipid metabolism, Synthesis of substrates in N-glycan biosythesis, Termination of O-glycan biosynthesis, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: P97325
Entrez ID: 20441
|
Does Knockout of Myo5a in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Myo5a
|
cell cycle progression
|
breast epithelium
|
Gene: Myo5a (myosin VA)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, actin filament-based movement, axo-dendritic protein transport, cellular response to insulin stimulus, chemical synaptic transmission, developmental pigmentation, dopamine metabolic process, endocytosis, endoplasmic reticulum localization, establishment of endoplasmic reticulum localization to postsynapse, exocytosis, hair follicle maturation, insulin secretion, locomotion involved in locomotory behavior, long-chain fatty acid biosynthetic process, macroautophagy, melanin biosynthetic process, melanin metabolic process, melanocyte differentiation, melanosome localization, melanosome transport, myelination, negative regulation of dopamine secretion, negative regulation of synaptic transmission, glutamatergic, odontogenesis, phenol-containing compound metabolic process, pigmentation, positive regulation of cellular response to insulin stimulus, positive regulation of protein localization to plasma membrane, positive regulation of vascular associated smooth muscle cell migration, post-Golgi vesicle-mediated transport, protein localization to plasma membrane, protein transport, protein-containing complex assembly, reactive gliosis, regulation of exocytosis, regulation of postsynaptic cytosolic calcium ion concentration, secretory granule localization, synapse organization, vesicle transport along actin filament, vesicle-mediated transport, visual perception; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein binding, SNARE binding, actin binding, actin filament binding, calcium ion binding, calcium-dependent protein binding, calmodulin binding, cytoskeletal motor activity, disordered domain specific binding, enzyme binding, identical protein binding, microfilament motor activity, nucleotide binding, protein binding, protein kinase binding, protein-containing complex binding, small GTPase binding, syntaxin-1 binding; CC: Golgi apparatus, Schaffer collateral - CA1 synapse, actin cytoskeleton, actin filament, actomyosin, actomyosin, myosin complex part, axon, cytoplasm, cytosol, dendrite, early endosome, endoplasmic reticulum, filopodium tip, glutamatergic synapse, insulin-responsive compartment, intermediate filament, late endosome, lysosome, melanosome, membrane, myosin complex, neuronal cell body, peroxisome, photoreceptor outer segment, postsynapse, postsynaptic actin cytoskeleton, recycling endosome, ribonucleoprotein complex, ruffle, secretory granule, smooth endoplasmic reticulum, synaptic vesicle, unconventional myosin complex, vesicle
Pathways: Developmental Biology, Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Regulation of MITF-M-dependent genes involved in pigmentation, Regulation of actin dynamics for phagocytic cup formation
UniProt: Q99104
Entrez ID: 17918
|
Does Knockout of Mrpl19 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Mrpl19
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrpl19 (mitochondrial ribosomal protein L19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, nucleus, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D338
Entrez ID: 56284
|
Does Knockout of Lrrc49 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Lrrc49
|
response to virus
|
Microglial Cell Line
|
Gene: Lrrc49 (leucine rich repeat containing 49)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium disassembly, microtubule cytoskeleton organization, microtubule polymerization; CC: centriolar satellite, cytoplasm, cytoskeleton, cytosol, microtubule
Pathways:
UniProt: Q91YK0
Entrez ID: 102747
|
Does Knockout of Stac2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Stac2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Stac2 (SH3 and cysteine rich domain 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of protein localization to plasma membrane, positive regulation of voltage-gated calcium channel activity, skeletal muscle contraction; MF: metal ion binding, molecular_function, zinc ion binding; CC: cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane, plasma membrane, sarcolemma
Pathways:
UniProt: Q8R1B0
Entrez ID: 217154
|
Does Knockout of Copg1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Copg1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Copg1 (coatomer protein complex, subunit gamma 1)
Type: protein-coding
Summary: Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Located in Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study combined immunodeficiency and polyclonal hypergammaglobulinemia. Human ortholog(s) of this gene implicated in immunodeficiency 128. Orthologous to human COPG1 (COPI coat complex subunit gamma 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of Golgi localization, intra-Golgi vesicle-mediated transport, intracellular protein transport, organelle transport along microtubule, protein secretion, protein transport, vesicle-mediated transport; CC: COPI vesicle coat, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, membrane, membrane coat
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9QZE5
Entrez ID: 54161
|
Does Knockout of Slu7 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Slu7
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Slu7 (SLU7 splicing factor homolog (S. cerevisiae))
Type: protein-coding
Summary: Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, alternative mRNA splicing, via spliceosome, cellular response to heat, intracellular protein transport, mRNA 3'-splice site recognition, mRNA processing, mRNA splicing, via spliceosome; MF: metal ion binding, pre-mRNA 3'-splice site binding, second spliceosomal transesterification activity, zinc ion binding; CC: catalytic step 2 spliceosome, cytoplasm, cytosol, nuclear speck, nucleoplasm, nucleus, small nuclear ribonucleoprotein complex, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8BHJ9
Entrez ID: 193116
|
Does Knockout of Mmp27 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Mmp27
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mmp27 (matrix metallopeptidase 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen catabolic process, extracellular matrix organization, proteolysis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: endoplasmic reticulum, extracellular matrix
Pathways:
UniProt: F6QKX8, D3Z6I1, D3YV89
Entrez ID: 234911
|
Does Knockout of Sap18b in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 2,176
|
Knockout
|
Sap18b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sap18b (Sin3-associated polypeptide 18B)
Type: protein-coding
Summary: This intronless gene is highly similar to the multi-exon Sap18 gene on chromosome 14, whose product functions in transcriptional repression as a component of the Sin3 histone deacetylase complex. This gene may possibly be a Sap18 pseudogene, but it is represented as protein-coding because it appears to be transcribed and has an intact ORF that would result in a protein that is 100% identical to the Sap18 protein. [provided by RefSeq, Dec 2008].
Gene Ontology:
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: D3YY73, E9Q317, D3Z2N9, D3YY55
Entrez ID: 100041953
|
Does Knockout of U2surp in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
U2surp
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: U2surp (U2 snRNP-associated SURP domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, biological_process; MF: RNA binding, molecular_function, nucleic acid binding; CC: U2 snRNP, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q6NV83
Entrez ID: 67958
|
Does Knockout of B3galt4 in Regulatory T cell causally result in cell proliferation?
| 1
| 2,127
|
Knockout
|
B3galt4
|
cell proliferation
|
Regulatory T cell
|
Gene: B3galt4 (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ganglioside biosynthetic process, lipid metabolic process, protein O-linked glycosylation, protein glycosylation; MF: N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity, ganglioside galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Blood group systems biosynthesis, Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - ganglio series - Mus musculus (mouse), Glycosphingolipid metabolism, Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of lipids, Sphingolipid metabolism
UniProt: Q9Z0F0
Entrez ID: 54218
|
Does Knockout of Spaca6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Spaca6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Spaca6 (sperm acrosome associated 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fusion of sperm to egg plasma membrane involved in single fertilization, single fertilization, sperm-egg recognition; MF: molecular_function, protein-macromolecule adaptor activity; CC: acrosomal membrane, acrosomal vesicle, cytoplasmic vesicle, membrane, plasma membrane
Pathways:
UniProt: E9Q8Q8
Entrez ID: 75202
|
Does Knockout of Zfp628 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Zfp628
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Zfp628 (zinc finger protein 628)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: developmental process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8CJ78
Entrez ID: 232816
|
Does Knockout of Fyco1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Fyco1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fyco1 (FYVE and coiled-coil domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: plus-end-directed vesicle transport along microtubule, positive regulation of autophagosome maturation; MF: metal ion binding, zinc ion binding; CC: Golgi apparatus, autophagosome, cytoplasmic vesicle, endosome, late endosome, lysosome
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q8VDC1
Entrez ID: 17281
|
Does Knockout of Wdr1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Wdr1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Wdr1 (WD repeat domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament depolymerization, actin filament fragmentation, apical junction assembly, cortical cytoskeleton organization, establishment of planar polarity of follicular epithelium, locomotion, maintenance of epithelial cell apical/basal polarity, neutrophil mediated immunity, neutrophil migration, platelet formation, positive regulation of actin filament depolymerization, regulation of actin filament depolymerization, regulation of cell shape, regulation of oligodendrocyte differentiation, regulation of ventricular cardiac muscle cell membrane repolarization, sarcomere organization, sensory perception of sound; MF: actin binding, actin filament binding; CC: actin cytoskeleton, anchoring junction, cell junction, cell projection, cell-cell junction, cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, glutamatergic synapse, myelin sheath, plasma membrane, podosome, synapse
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: O88342
Entrez ID: 22388
|
Does Knockout of Rnf43 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Rnf43
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rnf43 (ring finger protein 43)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt receptor catabolic process, Wnt signaling pathway, negative regulation of Wnt signaling pathway, protein ubiquitination, stem cell proliferation, ubiquitin-dependent protein catabolic process; MF: frizzled binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear envelope, nucleus, plasma membrane
Pathways: Regulation of FZD by ubiquitination, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q5NCP0
Entrez ID: 207742
|
Does Knockout of Hic1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Hic1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hic1 (hypermethylated in cancer 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of DNA damage response, signal transduction by p53 class mediator, regulation of signal transduction, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, histone deacetylase binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromatin, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription factors
UniProt: Q9R1Y5
Entrez ID: 15248
|
Does Knockout of Wfdc10 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Wfdc10
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Wfdc10 (WAP four-disulfide core domain 10)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be active in extracellular space. Orthologous to several human genes including WFDC10A (WAP four-disulfide core domain 10A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: antibacterial humoral response, innate immune response; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q3V2J9
Entrez ID: 629756
|
Does Knockout of Dnaja3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Dnaja3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dnaja3 (DnaJ heat shock protein family (Hsp40) member A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation in thymus, activation-induced cell death of T cells, apoptotic process, cellular senescence, immune system process, mitochondrial DNA replication, mitochondrion organization, negative regulation of apoptotic process, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cell population proliferation, negative regulation of programmed cell death, negative regulation of transcription by RNA polymerase II, negative regulation of type II interferon-mediated signaling pathway, neuromuscular junction development, positive regulation of T cell proliferation, positive regulation of apoptotic process, positive regulation of protein ubiquitination, protein folding, protein stabilization, regulation of cell population proliferation, regulation of immune system process, response to heat, response to stress, response to type II interferon, skeletal muscle acetylcholine-gated channel clustering, small GTPase-mediated signal transduction; MF: ATP binding, DNA-binding transcription factor binding, GTPase regulator activity, Hsp70 protein binding, IkappaB kinase complex binding, NF-kappaB binding, RNA polymerase II-specific DNA-binding transcription factor binding, heat shock protein binding, metal ion binding, protein binding, protein kinase binding, protein-containing complex binding, receptor tyrosine kinase binding, signaling receptor binding, type II interferon receptor binding, unfolded protein binding, zinc ion binding; CC: actin filament, cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, neuromuscular junction, nucleus, plasma membrane, postsynaptic membrane, synapse
Pathways: Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q99M87
Entrez ID: 83945
|
Does Knockout of Prpf40b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Prpf40b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prpf40b (pre-mRNA processing factor 40B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome; CC: U1 snRNP, U2-type prespliceosome, nuclear matrix, nuclear speck, nucleus
Pathways: Spliceosome - Mus musculus (mouse)
UniProt: Q80W14
Entrez ID: 54614
|
Does Knockout of Hells in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Hells
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Hells (helicase, lymphoid specific)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cell division, cellular response to leukemia inhibitory factor, chromatin remodeling, chromosomal DNA methylation maintenance following DNA replication, double-strand break repair, double-strand break repair via homologous recombination, heterochromatin formation, kidney development, lymphocyte differentiation, lymphocyte proliferation, negative regulation of apoptotic process, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of intrinsic apoptotic signaling pathway, pericentric heterochromatin formation, urogenital system development; MF: ATP binding, ATP-dependent chromatin remodeler activity, chromatin binding, chromatin-protein adaptor activity, helicase activity, hydrolase activity, nucleotide binding, protein binding; CC: chromosome, centromeric region, nucleus, pericentric heterochromatin, site of double-strand break
Pathways:
UniProt: Q60848
Entrez ID: 15201
|
Does Knockout of Mcur1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,288
|
Knockout
|
Mcur1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mcur1 (mitochondrial calcium uniporter regulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium import into the mitochondrion, calcium ion import, calcium ion transmembrane transport, calcium ion transport, cell migration, cell population proliferation, establishment of localization in cell, generation of precursor metabolites and energy, mitochondrial calcium ion transmembrane transport, monoatomic ion transport, positive regulation of mitochondrial calcium ion concentration, protein heterooligomerization; MF: molecular_function, protein-containing complex binding, protein-macromolecule adaptor activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CXD6
Entrez ID: 76137
|
Does Knockout of Cpsf1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Cpsf1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cpsf1 (cleavage and polyadenylation specific factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, mRNA processing; MF: RNA binding, enzyme binding, mRNA 3'-UTR AU-rich region binding, nucleic acid binding; CC: mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9EPU4
Entrez ID: 94230
|
Does Knockout of Pfkfb4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Pfkfb4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pfkfb4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate phosphorylation, fructose 2,6-bisphosphate metabolic process, fructose metabolic process, gluconeogenesis, glycolytic process; MF: 6-phosphofructo-2-kinase activity, ATP binding, catalytic activity, fructose-2,6-bisphosphate 2-phosphatase activity, hydrolase activity, kinase activity, nucleotide binding, transferase activity; CC: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex, cytosol
Pathways: AMPK signaling pathway - Mus musculus (mouse), Fructose and mannose metabolism - Mus musculus (mouse), Glucose metabolism, Glycolysis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
UniProt: Q6DTY7
Entrez ID: 270198
|
Does Knockout of Pggt1b in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 1
| 1,522
|
Knockout
|
Pggt1b
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Pggt1b (protein geranylgeranyltransferase type I, beta subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell cycle, positive regulation of cell population proliferation, protein geranylgeranylation; MF: CAAX-protein geranylgeranyltransferase activity, catalytic activity, heterocyclic compound binding, metal ion binding, peptide binding, prenyltransferase activity, protein geranylgeranyltransferase activity, protein prenyltransferase activity, small molecule binding, transferase activity, zinc ion binding; CC: CAAX-protein geranylgeranyltransferase complex
Pathways:
UniProt: Q8BUY9
Entrez ID: 225467
|
Does Knockout of Mall in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Mall
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mall (mal, T cell differentiation protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi membrane, clathrin-coated vesicle, cytoplasmic vesicle, membrane, membrane raft, plasma membrane
Pathways:
UniProt: Q91X49
Entrez ID: 228576
|
Does Knockout of Utp15 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Utp15
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Utp15 (UTP15 small subunit processome component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; CC: cytoplasm, endoplasmic reticulum, fibrillar center, nucleolus, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8C7V3
Entrez ID: 105372
|
Does Knockout of Ric8a in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Ric8a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ric8a (RIC8 guanine nucleotide exchange factor A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, basement membrane organization, cell migration involved in gastrulation, cell-cell adhesion involved in gastrulation, gastrulation, in utero embryonic development, protein folding, regulation of G protein-coupled receptor signaling pathway, response to light stimulus, vasculature development, visual learning; MF: G-protein alpha-subunit binding, GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding, protein folding chaperone; CC: cell cortex, cytoplasm, cytosol, membrane, plasma membrane
Pathways: cyclic AMP biosynthesis
UniProt: Q3TIR3
Entrez ID: 101489
|
Does Knockout of Fabp6 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 0
| 1,522
|
Knockout
|
Fabp6
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Fabp6 (fatty acid binding protein 6)
Type: protein-coding
Summary: The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within the ileum, the distal 25-30% of the small intestine, and plays a role in enterohepatic circulation of bile acids and cholesterol homeostasis. In humans, it has been reported that polymorphisms in FABP6 confer a protective effect in obese individuals from developing type 2 diabetes. In mice deficiency of this gene affects bile acid metabolism in a gender-specific manner and was reported to be required for efficient apical to basolateral transport of conjugated bile acids. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: bile acid metabolic process, fatty acid transport, lipid transport; MF: fatty acid binding, lipid binding; CC: cytoplasm, cytosol, membrane, nucleus
Pathways: Bile acid and bile salt metabolism, Metabolism, Metabolism of lipids, Metabolism of steroids, PPAR signaling pathway - Mus musculus (mouse), Recycling of bile acids and salts, Triglyceride catabolism, Triglyceride metabolism
UniProt: P51162
Entrez ID: 16204
|
Does Knockout of Gjd3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Gjd3
|
cell cycle progression
|
breast epithelium
|
Gene: Gjd3 (gap junction protein, delta 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AV node cell to bundle of His cell communication by electrical coupling, cell communication, cell-cell signaling, gap junction assembly, monoatomic ion transmembrane transport, negative regulation of cardiac conduction, negative regulation of cell communication by electrical coupling involved in cardiac conduction, negative regulation of heart rate, response to glucose, transmembrane transport; MF: gap junction channel activity, gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling, monoatomic ion channel activity; CC: anchoring junction, cell surface, connexin complex, gap junction, membrane, plasma membrane
Pathways: Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q91YD1
Entrez ID: 353155
|
Does Knockout of Ces2b in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Ces2b
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Ces2b (carboxyesterase 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carboxylesterase activity, carboxylic ester hydrolase activity, hydrolase activity
Pathways: Aspirin ADME, Biological oxidations, Drug ADME, Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Phase I - Functionalization of compounds
UniProt: E0CXA5, Q6PDB7
Entrez ID: 234669
|
Does Knockout of Avil in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Avil
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Avil (advillin)
Type: protein-coding
Summary: Predicted to enable Arp2/3 complex binding activity; actin filament binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in positive regulation of neuron projection development. Predicted to be located in several cellular components, including actin filament; focal adhesion; and lamellipodium. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including eye; forelimb; nervous system; skin; and tongue papillae. Human ortholog(s) of this gene implicated in nephrotic syndrome type 21. Orthologous to human AVIL (advillin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: actin filament capping, actin filament organization, actin filament severing, actin polymerization or depolymerization, barbed-end actin filament capping, cilium assembly, cytoskeleton organization, nervous system development, positive regulation of lamellipodium assembly, positive regulation of neuron projection development, regulation of diacylglycerol biosynthetic process, regulation of plasma membrane bounded cell projection organization; MF: Arp2/3 complex binding, actin binding, actin filament binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: actin cytoskeleton, actin filament, anchoring junction, axon, cell projection, cytoplasm, cytoskeleton, focal adhesion, lamellipodium, neuron projection
Pathways:
UniProt: O88398
Entrez ID: 11567
|
Does Knockout of Pam16 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Pam16
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pam16 (presequence translocase-asssociated motor 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, negative regulation of apoptotic signaling pathway, ossification, protein import into mitochondrial matrix, protein transport; CC: PAM complex, Tim23 associated import motor, TIM23 mitochondrial import inner membrane translocase complex, cytoplasm, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CQV1
Entrez ID: 66449
|
Does Knockout of Akap10 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Akap10
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Akap10 (A kinase anchor protein 10)
Type: protein-coding
Summary: This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. It has been reported that this protein is important for maintaining heart rate and myocardial contractility through its targeting of protein kinase A. In mouse, defects of this gene lead to cardiac arrhythmias and premature death. In humans, polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2013].
Gene Ontology: BP: intracellular protein localization; MF: protein kinase A binding; CC: cytoplasm, cytosol, membrane, mitochondrion, plasma membrane, protein-containing complex
Pathways: Factors involved in megakaryocyte development and platelet production, Hemostasis
UniProt: O88845
Entrez ID: 56697
|
Does Knockout of Otc in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Otc
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Otc (ornithine transcarbamylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-arginine biosynthetic process, L-arginine biosynthetic process via ornithine, L-ornithine catabolic process, amino acid biosynthetic process, amino acid metabolic process, ammonium homeostasis, citrulline biosynthetic process, liver development, midgut development, monoatomic anion homeostasis, ornithine metabolic process, response to biotin, response to insulin, response to nutrient levels, response to xenobiotic stimulus, response to zinc ion, urea cycle; MF: amino acid binding, carboxyl- or carbamoyltransferase activity, identical protein binding, ornithine carbamoyltransferase activity, phosphate ion binding, phospholipid binding, transferase activity; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Arginine biosynthesis - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Mitochondrial protein import, Protein localization, Urea cycle, arginine biosynthesis IV, citrulline biosynthesis, citrulline degradation, proline biosynthesis II (from arginine), superpathway of citrulline metabolism, urea cycle
UniProt: P11725
Entrez ID: 18416
|
Does Knockout of Nmd3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Nmd3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nmd3 (NMD3 ribosome export adaptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of RNA biosynthetic process, positive regulation of protein localization to nucleolus, protein transport, ribosomal large subunit export from nucleus; MF: protein-macromolecule adaptor activity, ribosomal large subunit binding; CC: cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse), Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q99L48
Entrez ID: 97112
|
Does Knockout of Nup188 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Nup188
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nup188 (nucleoporin 188)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein import into nucleus, protein transport; MF: structural constituent of nuclear pore; CC: nuclear envelope, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q6ZQH8
Entrez ID: 227699
|
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