prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Hhatl in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Hhatl
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Hhatl (hedgehog acyltransferase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of N-terminal protein palmitoylation, regulation of protein modification process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, perinuclear region of cytoplasm
Pathways: Hedgehog signaling pathway - Mus musculus (mouse)
UniProt: Q9D1G3
Entrez ID: 74770
|
Does Knockout of Zfp773 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Zfp773
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Zfp773 (zinc finger protein 773)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q149T8, Q9CZ29, Q3V3V8, A0A1B0GRS1
Entrez ID: 76373
|
Does Knockout of Hoxc6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Hoxc6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hoxc6 (homeobox C6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, embryonic skeletal system development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: P10629
Entrez ID: 15425
|
Does Knockout of Gfi1b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Gfi1b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gfi1b (growth factor independent 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of granulocyte differentiation, positive regulation of transcription by RNA polymerase II, regulation of erythrocyte differentiation, regulation of hemopoiesis, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nuclear matrix, nucleoplasm, nucleus, plasma membrane, transcription regulator complex
Pathways:
UniProt: O70237
Entrez ID: 14582
|
Does Knockout of Lap3 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Lap3
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Lap3 (leucine aminopeptidase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: aminopeptidase activity, carboxypeptidase activity, hydrolase activity, manganese ion binding, metal ion binding, metalloaminopeptidase activity, peptidase activity; CC: cytoplasm, mitochondrion, trans-Golgi network
Pathways: Arginine and proline metabolism - Mus musculus (mouse), Glutathione metabolism - Mus musculus (mouse)
UniProt: Q9CPY7
Entrez ID: 66988
|
Does Knockout of Aldh1a1 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Aldh1a1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Aldh1a1 (aldehyde dehydrogenase family 1, subfamily A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 9-cis-retinoic acid biosynthetic process, 9-cis-retinoic acid metabolic process, aldehyde metabolic process, cellular detoxification of aldehyde, embryonic eye morphogenesis, fructosamine catabolic process, fructose catabolic process, gamma-aminobutyric acid biosynthetic process, lipid metabolic process, maintenance of lens transparency, negative regulation of cold-induced thermogenesis, optic cup morphogenesis involved in camera-type eye development, positive regulation of apoptotic process, response to ethanol, response to oxidative stress, response to xenobiotic stimulus, retinoic acid biosynthetic process, retinoic acid metabolic process, retinoid metabolic process, retinol metabolic process; MF: 3-chloroallyl aldehyde dehydrogenase activity, 3-deoxyglucosone dehydrogenase activity, NAD binding, acetaldehyde dehydrogenase (NAD+) activity, aldehyde dehydrogenase (NAD+) activity, aminobutyraldehyde dehydrogenase (NAD+) activity, benzaldehyde dehydrogenase (NAD+) activity, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, retinal dehydrogenase (NAD+) activity; CC: axon, cell projection, cytoplasm, cytosol, synapse
Pathways: Biological oxidations, Ethanol oxidation, Fructose catabolism, Fructose metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Phase I - Functionalization of compounds, RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid
UniProt: P24549
Entrez ID: 11668
|
Does Knockout of Ric1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Ric1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ric1 (RAB6A GEF complex partner 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cranial skeletal system development, intracellular protein transport, negative regulation of protein catabolic process, positive regulation of GTPase activity, regulation of extracellular matrix constituent secretion, retrograde transport, endosome to Golgi; MF: guanyl-nucleotide exchange factor activity, small GTPase binding; CC: Golgi membrane, Ric1-Rgp1 guanyl-nucleotide exchange factor complex, cytoplasm, cytosol, membrane, protein-containing complex
Pathways:
UniProt: F7CN51, E9QPA1, F7DEJ0, F6S7U1
Entrez ID: 226089
|
Does Knockout of Foxn1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Foxn1
|
response to virus
|
Microglial Cell Line
|
Gene: Foxn1 (forkhead box N1)
Type: protein-coding
Summary: The protein encoded by this gene is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: T cell homeostasis, T cell lineage commitment, blood vessel morphogenesis, cell differentiation, epidermis development, hair follicle development, hemopoiesis, keratinocyte differentiation, lymphocyte homeostasis, lymphoid lineage cell migration into thymus, nail development, positive regulation of epithelial cell differentiation, positive regulation of hair follicle development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of T cell differentiation in thymus, regulation of gene expression, regulation of positive thymic T cell selection, regulation of transcription by RNA polymerase II, thymus development, thymus epithelium morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific DNA binding, transcription cis-regulatory region binding
Pathways:
UniProt: Q61575
Entrez ID: 15218
|
Does Knockout of Pcna in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Pcna
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pcna (proliferating cell nuclear antigen)
Type: protein-coding
Summary: Enables enzyme binding activity. Involved in mitotic telomere maintenance via semi-conservative replication and replication fork processing. Acts upstream of or within base-excision repair, gap-filling; cellular response to xenobiotic stimulus; and negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus; nuclear lamina; and replication fork. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including brain; genitourinary system; jaw; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in ataxia-telangiectasia-like disorder-2. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, base-excision repair, gap-filling, cellular response to UV, cellular response to hydrogen peroxide, cellular response to xenobiotic stimulus, chromatin organization, epithelial cell differentiation, estrous cycle, heart development, leading strand elongation, liver regeneration, mismatch repair, mitotic telomere maintenance via semi-conservative replication, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regulation of DNA replication, positive regulation of deoxyribonuclease activity, regulation of DNA replication, replication fork processing, response to L-glutamate, response to cadmium ion, response to dexamethasone, response to estradiol, response to lipid, response to oxidative stress, translesion synthesis; MF: DNA binding, DNA polymerase binding, DNA polymerase processivity factor activity, MutLalpha complex binding, chromatin binding, damaged DNA binding, dinucleotide insertion or deletion binding, enzyme binding, histone acetyltransferase binding, identical protein binding, nuclear estrogen receptor binding, protein binding, protein-containing complex binding, purine-specific mismatch base pair DNA N-glycosylase activity, receptor tyrosine kinase binding; CC: PCNA complex, PCNA-p21 complex, centrosome, chromatin, cyclin-dependent protein kinase holoenzyme complex, male germ cell nucleus, nuclear body, nuclear lamina, nuclear replication fork, nucleoplasm, nucleus, replication fork
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatitis B - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Metabolism of proteins, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Post-translational protein modification, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Protein ubiquitination, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Synthesis of DNA, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Tight junction - Mus musculus (mouse), Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P17918
Entrez ID: 18538
|
Does Knockout of Klk9 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Klk9
|
response to virus
|
Microglial Cell Line
|
Gene: Klk9 (kallikrein related-peptidase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein maturation, proteolysis; MF: hydrolase activity, molecular_function, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular space, secretory granule
Pathways:
UniProt: Q32M27
Entrez ID: 101533
|
Does Knockout of Rassf9 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Rassf9
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rassf9 (Ras association (RalGDS/AF-6) domain family (N-terminal) member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular transport, signal transduction; MF: enzyme binding, protein domain specific binding; CC: cytosol, endosome, recycling endosome, trans-Golgi network transport vesicle membrane
Pathways:
UniProt: Q8K342
Entrez ID: 237504
|
Does Knockout of Dpys in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Dpys
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dpys (dihydropyrimidinase)
Type: protein-coding
Summary: Enables dihydropyrimidinase activity and phosphoprotein binding activity. Involved in pyrimidine nucleoside monophosphate catabolic process. Is active in cytosol. Is expressed in cranium. Human ortholog(s) of this gene implicated in dihydropyrimidinase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human DPYS (dihydropyrimidinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: CMP catabolic process, UMP catabolic process, beta-alanine metabolic process, dCMP catabolic process, dTMP catabolic process, dUMP catabolic process, pyrimidine nucleobase catabolic process, thymine catabolic process, uracil catabolic process, uracil metabolic process; MF: amino acid binding, dihydropyrimidinase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, identical protein binding, metal ion binding, phosphoprotein binding, thymine binding, uracil binding, zinc ion binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Pyrimidine catabolism, Pyrimidine metabolism - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse), uracil degradation II (reductive)
UniProt: Q9EQF5
Entrez ID: 64705
|
Does Knockout of Mettl5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Mettl5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mettl5 (methyltransferase 5, N6-adenosine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, positive regulation of translation, rRNA methylation, rRNA processing, stem cell differentiation; MF: S-adenosyl-L-methionine binding, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, nucleic acid binding, rRNA (adenine-N6-)-methyltransferase activity, transferase activity; CC: cell projection, cytosol, fibrillar center, nucleolus, nucleus, postsynapse, presynapse, synapse
Pathways:
UniProt: Q8K1A0
Entrez ID: 75422
|
Does Knockout of Hrh3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Hrh3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hrh3 (histamine receptor H3)
Type: protein-coding
Summary: Predicted to enable several functions, including amine binding activity; histamine receptor activity; and neurotransmitter receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; learning or memory; and regulation of secretion. Predicted to be active in dendrite; plasma membrane; and synapse. Is expressed in brain. Orthologous to human HRH3 (histamine receptor H3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway, cAMP metabolic process, chemical synaptic transmission, cognition, drinking behavior, eating behavior, learning, memory, negative regulation of blood pressure, negative regulation of gamma-aminobutyric acid secretion, negative regulation of glutamate secretion, negative regulation of serotonin secretion, positive regulation of arachidonate secretion, positive regulation of cytosolic calcium ion concentration, positive regulation of epithelial cell proliferation, regulation of norepinephrine secretion, response to forskolin, signal transduction; MF: G protein-coupled receptor activity, amine binding, heterocyclic compound binding, histamine receptor activity, neurotransmitter receptor activity; CC: dendrite, membrane, plasma membrane, synapse
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), GPCR ligand binding, Histamine receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P58406
Entrez ID: 99296
|
Does Knockout of Med12 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Med12
|
response to virus
|
Microglial Cell Line
|
Gene: Med12 (mediator complex subunit 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell development, Wnt signaling pathway, planar cell polarity pathway, axis elongation involved in somitogenesis, embryonic brain development, embryonic neurocranium morphogenesis, embryonic organ development, endoderm development, heart development, neural tube closure, neural tube development, oligodendrocyte development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, post-anal tail morphogenesis, protein ubiquitination, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance, somitogenesis, spinal cord development; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, beta-catenin binding, chromatin binding, nuclear thyroid hormone receptor binding, protein binding, transcription coactivator activity, transcription coregulator activity, ubiquitin protein ligase activity; CC: CKM complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: A2AGH6
Entrez ID: 59024
|
Does Knockout of Kmt2b in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Kmt2b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Kmt2b (lysine (K)-specific methyltransferase 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, chromatin organization, epigenetic regulation of gene expression, maternal-to-zygotic transition of gene expression, methylation, oocyte development, ovarian follicle development, ovulation, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: DNA binding, histone H3K4 methyltransferase activity, histone H3K4 monomethyltransferase activity, histone H3K4 trimethyltransferase activity, metal ion binding, methyltransferase activity, transferase activity, unmethylated CpG binding, zinc ion binding; CC: MLL1/2 complex, cytosol, histone methyltransferase complex, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Generic Transcription Pathway, Lysine degradation - Mus musculus (mouse), PKMTs methylate histone lysines, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Transcriptional regulation by RUNX1
UniProt: O08550
Entrez ID: 75410
|
Does Knockout of Cpne2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Cpne2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Cpne2 (copine II)
Type: protein-coding
Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to calcium ion; MF: calcium-dependent phospholipid binding, metal ion binding; CC: clathrin-coated endocytic vesicle, cytoplasm, membrane, nucleus, plasma membrane
Pathways:
UniProt: P59108
Entrez ID: 234577
|
Does Knockout of Arl13a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Arl13a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Arl13a (ADP-ribosylation factor-like 13A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: non-motile cilium assembly, receptor localization to non-motile cilium; MF: GTP binding, GTPase activity, nucleotide binding; CC: ciliary membrane, cilium, motile cilium, non-motile cilium
Pathways:
UniProt: Q9D416
Entrez ID: 74448
|
Does Knockout of Kdm5a in Melanoma Cell Line causally result in tumorigenicity?
| 1
| 616
|
Knockout
|
Kdm5a
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Kdm5a (lysine demethylase 5A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, circadian regulation of gene expression, facultative heterochromatin formation, male gonad development, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, rhythmic process, spermatogenesis; MF: DNA binding, chromatin DNA binding, chromatin binding, dioxygenase activity, enzyme inhibitor activity, histone H3K4 demethylase activity, histone H3K4me/H3K4me2/H3K4me3 demethylase activity, histone binding, metal ion binding, oxidoreductase activity, protein binding, transcription cis-regulatory region binding, transcription coactivator activity, zinc ion binding; CC: chromatin, nucleolus, nucleoplasm, nucleus, protein-DNA complex
Pathways: Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones
UniProt: Q3UXZ9
Entrez ID: 214899
|
Does Knockout of Ccl9 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Ccl9
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Ccl9 (C-C motif chemokine ligand 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, immune response, inflammatory response, negative regulation of myoblast differentiation, positive regulation of cell migration, positive regulation of osteoclast differentiation; MF: CCR chemokine receptor binding, CCR1 chemokine receptor binding, chemoattractant activity, chemokine activity, cytokine activity; CC: extracellular region, extracellular space
Pathways: Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Formyl peptide receptors bind formyl peptides and many other ligands, G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P51670
Entrez ID: 20308
|
Does Knockout of Mfsd11 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Mfsd11
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mfsd11 (major facilitator superfamily domain containing 11)
Type: protein-coding
Summary: Acts upstream of or within response to food and response to starvation. Predicted to be located in membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system; liver; and spinal cord. Orthologous to human MFSD11 (major facilitator superfamily domain containing 11). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, response to food, response to starvation; CC: cellular_component, membrane
Pathways:
UniProt: Q8BJ51
Entrez ID: 69900
|
Does Knockout of Psg18 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Psg18
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Psg18 (pregnancy specific beta-1-glycoprotein 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokinin biosynthetic process, positive regulation of gene expression, regulation of immune system process, regulation of interleukin-10 production, signal transduction; CC: cell surface, plasma membrane
Pathways: Cell surface interactions at the vascular wall, Hemostasis, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: E9Q8L0, B2RSG7, Q3TIY4, S4R2S1
Entrez ID: 26438
|
Does Knockout of 4930555G01Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
4930555G01Rik
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: 4930555G01Rik (RIKEN cDNA 4930555G01 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Tsc1 in Lung Cancer Cell Line causally result in tumorigenicity?
| 1
| 1,089
|
Knockout
|
Tsc1
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Tsc1 (TSC complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import, TORC1 signaling, adaptive immune response, adult locomotory behavior, associative learning, cardiac muscle cell differentiation, cell projection organization, cell-matrix adhesion, cellular response to decreased oxygen levels, cellular response to starvation, cerebral cortex development, hippocampus development, kidney development, memory T cell differentiation, myelination, negative regulation of ATP-dependent activity, negative regulation of TOR signaling, negative regulation of TORC1 signaling, negative regulation of cell population proliferation, negative regulation of cell size, negative regulation of cellular response to oxidative stress, negative regulation of macroautophagy, negative regulation of neuron projection development, nervous system development, neural tube closure, positive regulation of TORC1 signaling, positive regulation of focal adhesion assembly, positive regulation of macroautophagy, positive regulation of stress fiber assembly, potassium ion transport, protein folding, protein stabilization, regulation of cell cycle, regulation of cell-matrix adhesion, regulation of focal adhesion assembly, regulation of stress fiber assembly, response to insulin, synapse organization; MF: ATPase inhibitor activity, Hsp70 protein binding, Hsp90 protein binding, protein binding, protein folding chaperone, protein-folding chaperone binding; CC: TSC1-TSC2 complex, actin filament, cell cortex, cell projection, ciliary basal body, cytoplasm, cytosol, growth cone, lamellipodium, lipid droplet, lysosomal membrane, lysosome, membrane, nucleus, perinuclear region of cytoplasm, postsynaptic density, protein folding chaperone complex, protein-containing complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Inhibition of TSC complex formation by PKB, Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), MTOR signalling, Macroautophagy, Membrane Trafficking, PI3K-Akt signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Rab regulation of trafficking, Signal Transduction, TBC/RABGAPs, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, Vesicle-mediated transport, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9EP53
Entrez ID: 64930
|
Does Knockout of Rasl10b in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Rasl10b
|
response to virus
|
Microglial Cell Line
|
Gene: Rasl10b (RAS-like, family 10, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of peptide hormone secretion, regulation of systemic arterial blood pressure by atrial natriuretic peptide; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q5SSG5
Entrez ID: 276952
|
Does Knockout of Dok4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Dok4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dok4 (docking protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, nervous system development, positive regulation of MAPK cascade
Pathways: Axon guidance, Developmental Biology, Nervous system development, RET signaling
UniProt: Q99KE3
Entrez ID: 114255
|
Does Knockout of Kctd20 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Kctd20
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Kctd20 (potassium channel tetramerisation domain containing 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, protein binding; CC: cytoplasm
Pathways:
UniProt: Q8CDD8
Entrez ID: 66989
|
Does Knockout of Mmp21 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Mmp21
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Mmp21 (matrix metallopeptidase 21)
Type: protein-coding
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. Mice harboring certain mutations in this gene exhibit congenital heart defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: collagen catabolic process, coronary vasculature development, determination of heart left/right asymmetry, determination of left/right symmetry, extracellular matrix organization, hematopoietic progenitor cell differentiation, proteolysis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular matrix, extracellular region
Pathways:
UniProt: Q8K3F2
Entrez ID: 214766
|
Does Knockout of Arhgef2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Arhgef2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arhgef2 (Rho/Rac guanine nucleotide exchange factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, asymmetric neuroblast division, cell differentiation, cell division, cell morphogenesis, cellular response to muramyl dipeptide, establishment of mitotic spindle orientation, immune system process, innate immune response, negative regulation of microtubule depolymerization, negative regulation of neurogenesis, negative regulation of podosome assembly, nervous system development, positive regulation of NF-kappaB transcription factor activity, positive regulation of interleukin-6 production, positive regulation of neuron differentiation, positive regulation of neuron migration, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, regulation of Rho protein signal transduction; MF: guanyl-nucleotide exchange factor activity, metal ion binding, microtubule binding, protein binding, small GTPase binding, zinc ion binding; CC: Golgi apparatus, anchoring junction, bicellular tight junction, cytoplasm, cytoplasmic vesicle, cytoskeleton, dendritic shaft, glutamatergic synapse, microtubule, neuronal cell body, podosome, postsynaptic density, postsynaptic density, intracellular component, protein-containing complex, ruffle membrane, spindle, vesicle
Pathways: Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), p75 NTR receptor-mediated signalling
UniProt: Q60875
Entrez ID: 16800
|
Does Knockout of Trmu in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Trmu
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Trmu (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA processing, tRNA wobble position uridine thiolation; MF: ATP binding, RNA binding, nucleotide binding, sulfurtransferase activity, tRNA binding, tRNA-5-taurinomethyluridine 2-sulfurtransferase, transferase activity; CC: mitochondrion
Pathways:
UniProt: Q9DAT5
Entrez ID: 72026
|
Does Knockout of Vmn1r7 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Vmn1r7
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vmn1r7 (vomeronasal 1 receptor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: E9Q8T0
Entrez ID: 434016
|
Does Knockout of Srp9 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Srp9
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Srp9 (signal recognition particle 9)
Type: protein-coding
Summary: Predicted to enable 7S RNA binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SRP9 (signal recognition particle 9). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, negative regulation of translational elongation; MF: 7S RNA binding, RNA binding; CC: cytoplasm, cytosol, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Mus musculus (mouse), SRP-dependent cotranslational protein targeting to membrane, Translation
UniProt: P49962
Entrez ID: 27058
|
Does Knockout of Tomm40 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Tomm40
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tomm40 (translocase of outer mitochondrial membrane 40)
Type: protein-coding
Summary: Predicted to enable monoatomic cation channel activity; preprotein binding activity; and protein transmembrane transporter activity. Predicted to be involved in positive regulation of apoptotic process; protein import into mitochondrial matrix; and protein insertion into mitochondrial membrane. Located in mitochondrial outer membrane. Is expressed in lung mesenchyme. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: monoatomic ion transport, positive regulation of apoptotic process, protein import into mitochondrial matrix, protein insertion into mitochondrial membrane, protein targeting to mitochondrion, protein transport, transmembrane transport; MF: monoatomic cation channel activity, porin activity, preprotein binding, protein transmembrane transporter activity; CC: cytosol, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial inner membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion, pore complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy, Macroautophagy, Mitophagy, PINK1-PRKN Mediated Mitophagy, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Selective autophagy
UniProt: Q9QYA2
Entrez ID: 53333
|
Does Knockout of Ywhae in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,547
|
Knockout
|
Ywhae
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Ywhae (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, MAPK cascade, cellular response to heat, cerebral cortex development, cytoplasmic pattern recognition receptor signaling pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of protein localization, hippo signaling, hippocampus development, intracellular potassium ion homeostasis, intracellular protein localization, negative regulation of calcium ion export across plasma membrane, negative regulation of toll-like receptor signaling pathway, neuron migration, positive regulation of hippo signaling, positive regulation of protein export from nucleus, positive regulation of toll-like receptor signaling pathway, protein K11-linked ubiquitination, protein localization to endoplasmic reticulum, protein localization to nucleus, protein targeting, regulation of cytosolic calcium ion concentration, regulation of membrane repolarization, regulation of mitotic cell cycle, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of potassium ion transmembrane transport, signal transduction, toll-like receptor 4 signaling pathway; MF: calcium channel inhibitor activity, calcium channel regulator activity, enzyme binding, enzyme inhibitor activity, histone deacetylase binding, identical protein binding, phosphoprotein binding, phosphoserine residue binding, potassium channel regulator activity, protein binding, protein domain specific binding, protein heterodimerization activity, protein phosphatase binding, protein phosphatase inhibitor activity, protein sequestering activity, protein-containing complex binding, scaffold protein binding, signaling adaptor activity, transmembrane transporter binding, ubiquitin protein ligase binding; CC: axon, central region of growth cone, cytoplasm, cytosol, endoplasmic reticulum, glutamatergic synapse, kinesin complex, melanosome, mitochondrion, nucleus, plasma membrane, synapse
Pathways: AURKA Activation by TPX2, Activation of BAD and translocation to mitochondria , Activation of BH3-only proteins, Anchoring of the basal body to the plasma membrane, Apoptosis, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cell death signalling via NRAGE, NRIF and NADE, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Cilium Assembly, Death Receptor Signaling, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, HSF1 activation, Hepatitis C - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Intrinsic Pathway for Apoptosis, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Membrane Trafficking, Mitotic G2-G2/M phases, Mitotic Prometaphase, NADE modulates death signalling, NOD-like receptor signaling pathway - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Organelle biogenesis and maintenance, PI3K-Akt signaling pathway - Mus musculus (mouse), Programmed Cell Death, RAB GEFs exchange GTP for GDP on RABs, RHO GTPase Effectors, RHO GTPases activate PKNs, RNA Polymerase II Transcription, Rab regulation of trafficking, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of HSF1-mediated heat shock response, Regulation of PLK1 Activity at G2/M Transition, Signal Transduction, Signaling by Hippo, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, Vesicle-mediated transport, Viral carcinogenesis - Mus musculus (mouse), p75 NTR receptor-mediated signalling
UniProt: P62259
Entrez ID: 22627
|
Does Knockout of Arhgap23 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Arhgap23
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Arhgap23 (Rho GTPase activating protein 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q69ZH9
Entrez ID: 58996
|
Does Knockout of Rap2b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Rap2b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rap2b (RAP2B, member of RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rap protein signal transduction, negative regulation of cell migration, platelet activation, platelet aggregation, regulation of protein tyrosine kinase activity, signal transduction; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein domain specific binding; CC: bicellular tight junction, bounding membrane of organelle, cell-cell contact zone, cytoplasmic vesicle membrane, cytosol, endomembrane system, endosome, extracellular exosome, membrane, membrane raft, plasma membrane, recycling endosome, recycling endosome membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P61226
Entrez ID: 74012
|
Does Knockout of Cacna1h in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Cacna1h
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cacna1h (calcium channel, voltage-dependent, T type, alpha 1H subunit)
Type: protein-coding
Summary: Voltage-dependent Ca(2+) channels mediate the entry of Ca(2+) ions into excitable cells and are involved in a variety of Ca(2+)-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. The protein encoded by this gene is an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: aldosterone biosynthetic process, calcium ion import, calcium ion transmembrane transport, calcium ion transport, cortisol biosynthetic process, inorganic cation transmembrane transport, membrane depolarization during action potential, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of acrosome reaction, positive regulation of calcium ion-dependent exocytosis, positive regulation of cardiac muscle cell contraction, regulation of membrane potential, sodium ion transmembrane transport, transmembrane transport; MF: calcium channel activity, low voltage-gated calcium channel activity, metal ion binding, monoatomic ion channel activity, protein binding, scaffold protein binding, voltage-gated calcium channel activity, voltage-gated monoatomic ion channel activity, voltage-gated sodium channel activity; CC: caveola, dendrite, glutamatergic synapse, membrane, monoatomic ion channel complex, neuron projection, perikaryon, plasma membrane, postsynaptic membrane, presynaptic active zone membrane, sarcolemma, voltage-gated calcium channel complex, voltage-gated sodium channel complex
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse)
UniProt: E0CYZ3, E9Q6P9, Q3UX23, A0AAA9WW37, Q9JJ85, A0AAA9WUV6, F6U5P7, F6USE5
Entrez ID: 58226
|
Does Knockout of Sec24b in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Sec24b
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Sec24b (SEC24 homolog B, COPII coat complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII-coated vesicle cargo loading, aorta morphogenesis, auditory receptor cell morphogenesis, auditory receptor cell stereocilium organization, circulatory system development, cochlear nucleus development, coronary artery morphogenesis, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, lung lobe morphogenesis, lung morphogenesis, neural tube closure, outflow tract morphogenesis, protein transport, pulmonary artery morphogenesis, regulation of cargo loading into COPII-coated vesicle, regulation of establishment of planar polarity involved in neural tube closure, vesicle-mediated transport; MF: SNARE binding, metal ion binding, protein binding, zinc ion binding; CC: COPII vesicle coat, COPII-coated ER to Golgi transport vesicle, ER to Golgi transport vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, membrane
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, Class I MHC mediated antigen processing & presentation, ER to Golgi Anterograde Transport, Immune System, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: F6YIN5, Q80ZX0, F6VJC5
Entrez ID: 99683
|
Does Knockout of Hsd17b2 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Hsd17b2
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Hsd17b2 (hydroxysteroid (17-beta) dehydrogenase 2)
Type: protein-coding
Summary: Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Acts upstream of or within in utero embryonic development and placenta development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal gland; genitourinary system; gut; labyrinthine zone; and liver. Orthologous to human HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: androgen biosynthetic process, androgen metabolic process, estrogen biosynthetic process, in utero embryonic development, lipid metabolic process, placenta development, response to retinoic acid, steroid biosynthetic process, steroid metabolic process; MF: estradiol 17-beta-dehydrogenase [NAD(P)+] activity, oxidoreductase activity, testosterone dehydrogenase (NAD+) activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Estrogen biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Ovarian steroidogenesis - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), biosynthesis of estrogens
UniProt: P51658
Entrez ID: 15486
|
Does Knockout of Tdh in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Tdh
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Tdh (L-threonine dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-threonine catabolic process, L-threonine catabolic process to glycine; MF: L-threonine 3-dehydrogenase activity, identical protein binding, oxidoreductase activity; CC: mitochondrion
Pathways: Glycine, serine and threonine metabolism - Mus musculus (mouse), threonine degradation III (to methylglyoxal)
UniProt: Q8K3F7
Entrez ID: 58865
|
Does Knockout of Xrn1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Xrn1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Xrn1 (5'-3' exoribonuclease 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA metabolic process, RNA processing, histone mRNA catabolic process, meiotic cell cycle, negative regulation of translation, nuclear mRNA surveillance, nuclear-transcribed mRNA catabolic process, rRNA catabolic process, telomere maintenance; MF: 5'-3' RNA exonuclease activity, 5'-3' exonuclease activity, DNA binding, G-quadruplex DNA binding, G-quadruplex RNA binding, RNA binding, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, protein binding, telomerase RNA binding; CC: P-body, cytoplasm, cytosol, dendrite, neuronal cell body, nucleus, plasma membrane
Pathways: RNA degradation - Mus musculus (mouse), Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: F8VQ87, A0A087WQN7, A0A087WNV6, A0A087WQ18
Entrez ID: 24127
|
Does Knockout of Glp1r in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Glp1r
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Glp1r (glucagon-like peptide 1 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, associative learning, cAMP/PKA signal transduction, cell surface receptor signaling pathway, cellular response to glucagon stimulus, feeding behavior, hormone secretion, insulin secretion, learning or memory, memory, negative regulation of apoptotic process, negative regulation of blood pressure, negative regulation of neuron apoptotic process, neuropeptide signaling pathway, positive regulation of blood pressure, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of cytosolic calcium ion concentration, positive regulation of insulin secretion, positive regulation of transcription by RNA polymerase II, post-translational protein targeting to membrane, translocation, protein transport, regulation of calcium ion transport, regulation of heart contraction, release of sequestered calcium ion into cytosol, response to glucose, response to psychosocial stress, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, glucagon receptor activity, glucagon-like peptide 1 receptor activity, peptide hormone binding, peptide receptor activity, signaling receptor activity, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Insulin secretion - Mus musculus (mouse), Integration of energy metabolism, Metabolism, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Regulation of insulin secretion, Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: O35659
Entrez ID: 14652
|
Does Knockout of Map10 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Map10
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Map10 (microtubule-associated protein 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cytoplasmic microtubule organization, microtubule cytoskeleton organization, mitotic spindle midzone assembly, positive regulation of cytokinesis, regulation of microtubule-based process; MF: microtubule binding; CC: centrosome, cytoplasm, cytoplasmic microtubule, cytoskeleton, midbody, mitotic spindle midzone, mitotic spindle pole, spindle pole
Pathways:
UniProt: Q8BJS7
Entrez ID: 74393
|
Does Knockout of Cyb5r1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Cyb5r1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cyb5r1 (cytochrome b5 reductase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: FAD binding, cytochrome-b5 reductase activity, acting on NAD(P)H, oxidoreductase activity; CC: cytosol, endoplasmic reticulum membrane, membrane, mitochondrion
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Erythrocytes take up carbon dioxide and release oxygen, Hemostasis, O2/CO2 exchange in erythrocytes, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, Transport of small molecules
UniProt: Q9DB73
Entrez ID: 72017
|
Does Knockout of Rdh16f2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Rdh16f2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rdh16f2 (RDH16 family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: androgen biosynthetic process, positive regulation of retinoic acid biosynthetic process, retinoic acid metabolic process, retinol metabolic process, steroid metabolic process; MF: all-trans-retinol dehydrogenase (NAD+) activity, androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, oxidoreductase activity; CC: endoplasmic reticulum membrane, intracellular membrane-bounded organelle, organelle membrane
Pathways: Retinol metabolism - Mus musculus (mouse)
UniProt: Q8K3M0, Q8K3M1
Entrez ID: 216454
|
Does Knockout of Fance in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Fance
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fance (Fanconi anemia, complementation group E)
Type: protein-coding
Summary: This gene encodes the complementation group E subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes: FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The FA complex is necessary for protection against DNA damage. This gene product is required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Defects in the related human gene are a cause of Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Translation of this protein is initiated at a non-AUG (CUG) start codon, which is inferred from the related human gene and the notion that this protein is functionally indispensable. Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2009].
Gene Ontology: BP: gene expression, homeostasis of number of cells, interstrand cross-link repair, ovarian follicle development; CC: Fanconi anaemia nuclear complex, centrosome, chromatin, chromosome, nucleoplasm
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: F7DAL6, B8JJD3, B8JJD2, B8JJD5, B8JJD1, B8JJD6, A0A3B2W3J1, B8JJD7, B8JJD8
Entrez ID: 72775
|
Does Knockout of Ogdh in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Ogdh
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ogdh (oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate decarboxylation to succinyl-CoA, 2-oxoglutarate metabolic process, cerebellar cortex development, generation of precursor metabolites and energy, glycolytic process, hippocampus development, olfactory bulb mitral cell layer development, pyramidal neuron development, striatum development, succinyl-CoA metabolic process, tangential migration from the subventricular zone to the olfactory bulb, thalamus development, tricarboxylic acid cycle; MF: heat shock protein binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, oxoglutarate dehydrogenase (succinyl-transferring) activity, protein-folding chaperone binding, thiamine pyrophosphate binding; CC: cytoplasm, mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleus, oxoglutarate dehydrogenase complex
Pathways: 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA, 2-ketoglutarate dehydrogenase complex, Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Glycine degradation, Glyoxylate metabolism and glycine degradation, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Mitochondrial protein degradation, OGDH complex synthesizes succinyl-CoA from 2-OG, lysine degradation II, tryptophan degradation III (eukaryotic)
UniProt: Q60597
Entrez ID: 18293
|
Does Knockout of Bri3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Bri3
|
cell cycle progression
|
breast epithelium
|
Gene: Bri3 (brain protein I3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding; CC: cytoplasm, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P28662
Entrez ID: 55950
|
Does Knockout of Necab1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Necab1
|
cell cycle progression
|
breast epithelium
|
Gene: Necab1 (N-terminal EF-hand calcium binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst hatching, regulation of amyloid precursor protein biosynthetic process; MF: calcium ion binding, identical protein binding, metal ion binding; CC: cilium, cytoplasm, cytosol, nucleoplasm
Pathways:
UniProt: Q8BG18
Entrez ID: 69352
|
Does Knockout of Vgll2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Vgll2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Vgll2 (vestigial like family member 2)
Type: protein-coding
Summary: This gene is a member of the Vestigial-like (Vgl) gene family and is upregulated during muscle differentiation. The product of this gene interacts with and modifies the DNA-binding properties of the transcription factor, TEF-1, and is important for muscle tissue development. Reduced expression of this gene leads to a reduction in the terminal differentiation of muscle cells. Alternate splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal muscle tissue development; MF: protein binding, transcription coactivator activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8BGW8
Entrez ID: 215031
|
Does Knockout of Urgcp in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Urgcp
|
cell proliferation
|
Regulatory T cell
|
Gene: Urgcp (upregulator of cell proliferation)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, molecular_function, nucleotide binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q5NCI0
Entrez ID: 72046
|
Does Knockout of Nlrx1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Nlrx1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nlrx1 (NLR family member X1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, innate immune response, negative regulation of RIG-I signaling pathway, negative regulation of canonical NF-kappaB signal transduction, negative regulation of inflammatory response, negative regulation of innate immune response, negative regulation of interferon-beta production, negative regulation of interleukin-6 production, negative regulation of macrophage cytokine production; MF: ATP binding, nucleotide binding, protein binding; CC: membrane, mitochondrial outer membrane, mitochondrion, plasma membrane
Pathways: Cytokine Signaling in Immune system, DDX58/IFIH1-mediated induction of interferon-alpha/beta, Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NOD-like receptor signaling pathway - Mus musculus (mouse), Negative regulators of DDX58/IFIH1 signaling, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of NF-kappa B signaling, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q3TL44
Entrez ID: 270151
|
Does Knockout of Pstpip2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,157
|
Knockout
|
Pstpip2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pstpip2 (proline-serine-threonine phosphatase-interacting protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: actin binding, protein binding; CC: cytoplasm, cytoskeleton, cytosol, membrane, plasma membrane
Pathways:
UniProt: Q99M15
Entrez ID: 19201
|
Does Knockout of Gatd1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Gatd1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gatd1 (glutamine amidotransferase like class 1 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lactate biosynthetic process, methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; CC: cytoplasm, early endosome, endosome, extracellular region
Pathways:
UniProt: Q8BFQ8
Entrez ID: 213350
|
Does Knockout of Esrrg in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Esrrg
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Esrrg (estrogen-related receptor gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear receptor-mediated steroid hormone signaling pathway, positive regulation of DNA-templated transcription, positive regulation of cold-induced thermogenesis, positive regulation of nucleobase-containing compound metabolic process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of macromolecule biosynthetic process, regulation of transcription by RNA polymerase II, retinoic acid receptor signaling pathway; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, calmodulin binding, estrogen response element binding, identical protein binding, metal ion binding, nuclear receptor activity, nuclear steroid receptor activity, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, steroid binding, zinc ion binding; CC: chromatin, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription
UniProt: P62509
Entrez ID: 26381
|
Does Knockout of Ddx59 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ddx59
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ddx59 (DEAD box helicase 59)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, mRNA binding, metal ion binding, nucleic acid binding, nucleotide binding, zinc ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9DBN9
Entrez ID: 67997
|
Does Knockout of Pdzd2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Pdzd2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Pdzd2 (PDZ domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: apical part of cell, cell-cell junction, centriolar satellite, cytoplasm, cytosol, endoplasmic reticulum, extracellular region, nucleus, plasma membrane
Pathways:
UniProt: A0A087WQ09, E9Q1M1, A0A087WS85, A0A087WRL4
Entrez ID: 68070
|
Does Knockout of Cdk2 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,536
|
Knockout
|
Cdk2
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Cdk2 (cyclin dependent kinase 2)
Type: protein-coding
Summary: Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and magnesium ion binding activity. Involved in peptidyl-serine phosphorylation and positive regulation of cell population proliferation. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; potassium ion transport; and regulation of nucleobase-containing compound metabolic process. Located in chromosome and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex and transcription regulator complex. Is expressed in several structures, including brain; branchial arch; ear; integumental system; and limb. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, DNA synthesis involved in mitotic DNA replication, G1/S transition of mitotic cell cycle, Ras protein signal transduction, cell division, cellular response to insulin stimulus, centriole replication, chromatin remodeling, meiotic cell cycle, negative regulation of transcription by RNA polymerase II, peptidyl-serine phosphorylation, positive regulation of DNA-templated DNA replication initiation, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of heterochromatin formation, post-translational protein modification, potassium ion transport, protection from non-homologous end joining at telomere, regulation of G2/M transition of mitotic cell cycle, regulation of gene expression, response to cAMP, response to electrical stimulus, signal transduction, telomere maintenance, telomere maintenance in response to DNA damage; MF: ATP binding, cyclin binding, cyclin-dependent protein kinase activity, cyclin-dependent protein serine/threonine kinase activity, histone kinase activity, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein domain specific binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: Cajal body, X chromosome, XY body, Y chromosome, centrosome, chromosome, telomeric region, condensed chromosome, cyclin A1-CDK2 complex, cyclin A2-CDK2 complex, cyclin E1-CDK2 complex, cyclin E2-CDK2 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytoskeleton, endosome, male germ cell nucleus, nuclear envelope, nucleoplasm, nucleus, transcription regulator complex
Pathways: APC/C-mediated degradation of cell cycle proteins, Activation of ATR in response to replication stress, Activation of the pre-replicative complex, CDK-mediated phosphorylation and removal of Cdc6, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Chromosome Maintenance, Cushing syndrome - Mus musculus (mouse), Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA Damage/Telomere Stress Induced Senescence, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, Developmental Biology, Epstein-Barr virus infection - Mus musculus (mouse), Extension of Telomeres, FoxO signaling pathway - Mus musculus (mouse), G0 and Early G1, G1 Phase, G1/S DNA Damage Checkpoints, G1/S Transition, G2 Phase, G2/M Checkpoints, G2/M Transition, Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Homology Directed Repair, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Oocyte meiosis - Mus musculus (mouse), Orc1 removal from chromatin, PI3K-Akt signaling pathway - Mus musculus (mouse), PTK6 Regulates Cell Cycle, Pathways in cancer - Mus musculus (mouse), Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, Processing of DNA double-strand break ends, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of mitotic cell cycle, S Phase, SCF(Skp2)-mediated degradation of p27/p21, Senescence-Associated Secretory Phenotype (SASP), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Small cell lung cancer - Mus musculus (mouse), Switching of origins to a post-replicative state, Synthesis of DNA, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, Telomere Extension By Telomerase, Telomere Maintenance, Transcriptional Regulation by TP53, Transcriptional regulation of granulopoiesis, Viral carcinogenesis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint
UniProt: P97377
Entrez ID: 12566
|
Does Knockout of Dll1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Dll1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dll1 (delta like canonical Notch ligand 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, Notch signaling pathway involved in arterial endothelial cell fate commitment, animal organ morphogenesis, astrocyte development, auditory receptor cell fate commitment, cell communication, cell differentiation, cell fate commitment, cell-cell signaling, cerebellar Purkinje cell layer structural organization, cerebellar molecular layer formation, clathrin-dependent endocytosis, compartment pattern specification, determination of left/right symmetry, embryo development ending in birth or egg hatching, embryonic morphogenesis, endothelial tip cell fate specification, endothelium development, energy homeostasis, epithelial cell development, epithelial tube morphogenesis, eye morphogenesis, heart looping, in utero embryonic development, inhibition of neuroepithelial cell differentiation, inner ear auditory receptor cell differentiation, inner ear development, inner ear morphogenesis, lateral inhibition, left/right axis specification, loop of Henle development, marginal zone B cell differentiation, multicellular organismal-level homeostasis, negative regulation of Notch signaling pathway, negative regulation of cardiac muscle cell differentiation, negative regulation of cell differentiation, negative regulation of cell population proliferation, negative regulation of developmental process, negative regulation of epidermal cell differentiation, negative regulation of epithelial cell differentiation, negative regulation of glial cell apoptotic process, negative regulation of hemocyte differentiation, negative regulation of inner ear auditory receptor cell differentiation, negative regulation of interleukin-10 production, negative regulation of multicellular organismal process, negative regulation of myeloid cell differentiation, negative regulation of myoblast differentiation, negative regulation of neuron differentiation, nephron development, nervous system development, neuron differentiation, neuron fate specification, neuronal stem cell population maintenance, odontogenesis of dentin-containing tooth, organ growth, positive regulation of Notch signaling pathway, positive regulation of cell population proliferation, positive regulation of endocytosis, positive regulation of gene expression, positive regulation of skeletal muscle tissue growth, positive regulation of sprouting angiogenesis, positive regulation of transcription by RNA polymerase II, proximal tubule development, proximal/distal pattern formation, regionalization, regulation of biological quality, regulation of blood pressure, regulation of cell adhesion, regulation of cell division, regulation of developmental growth, regulation of growth, regulation of macromolecule metabolic process, regulation of neurogenesis, regulation of primary metabolic process, regulation of skeletal muscle tissue growth, regulation of somitogenesis, regulation of transport, regulation of vascular endothelial growth factor receptor signaling pathway, regulation of vascular endothelial growth factor signaling pathway, renal tubule development, retina development in camera-type eye, retina morphogenesis in camera-type eye, skeletal muscle tissue growth, skin epidermis development, somite specification, somitogenesis, spinal cord development, type B pancreatic cell development, vasculature development; MF: Notch binding, Tat protein binding, calcium ion binding, protein binding, receptor ligand activity, scaffold protein binding; CC: adherens junction, anchoring junction, apical plasma membrane, cell-cell junction, cytoplasmic vesicle, membrane, membrane raft, nucleus, plasma membrane
Pathways: Breast cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, Notch signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signal Transduction, Signaling by NOTCH, Signaling by NOTCH2, Signaling by NOTCH3, Th1 and Th2 cell differentiation - Mus musculus (mouse)
UniProt: Q61483
Entrez ID: 13388
|
Does Knockout of Kcna1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Kcna1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Kcna1 (potassium voltage-gated channel, shaker-related subfamily, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, brain development, cell communication by electrical coupling, cellular response to magnesium ion, detection of mechanical stimulus involved in sensory perception of pain, detection of mechanical stimulus involved in sensory perception of touch, hippocampus development, intracellular protein localization, magnesium ion homeostasis, membrane repolarization during action potential, monoatomic ion transmembrane transport, monoatomic ion transport, neuroblast proliferation, neuromuscular process, neuronal action potential, neuronal signal transduction, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of membrane potential, regulation of muscle contraction, startle response, transmembrane transport; MF: delayed rectifier potassium channel activity, disordered domain specific binding, monoatomic ion channel activity, potassium channel activity, protein binding, voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, voltage-gated potassium channel activity; CC: anchoring junction, apical plasma membrane, axon, axon initial segment, axon terminus, calyx of Held, cell junction, cell projection, cell surface, cytoplasmic vesicle, cytosol, dendrite, endoplasmic reticulum, glutamatergic synapse, juxtaparanode region of axon, membrane, monoatomic ion channel complex, neuronal cell body, paranode region of axon, perikaryon, plasma membrane, postsynaptic membrane, potassium channel complex, presynapse, presynaptic membrane, synapse, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: P16388
Entrez ID: 16485
|
Does Knockout of Wwp1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Wwp1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Wwp1 (WW domain containing E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, lung development, negative regulation of DNA-templated transcription, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: anchoring junction, cytoplasm, cytosol, membrane, nucleus, plasma membrane
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Downregulation of ERBB4 signaling, Endocytosis - Mus musculus (mouse), Immune System, Ion channel transport, Signal Transduction, Signaling by ERBB4, Signaling by Receptor Tyrosine Kinases, Stimuli-sensing channels, Transport of small molecules, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8BZZ3
Entrez ID: 107568
|
Does Knockout of Tnpo1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Tnpo1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tnpo1 (transportin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, nucleocytoplasmic transport, protein import into nucleus, protein transport; MF: nuclear import signal receptor activity, nuclear localization sequence binding, protein binding, small GTPase binding; CC: cytoplasm, nuclear lumen, nucleolus, nucleoplasm, nucleus
Pathways: Cilium Assembly, Intraflagellar transport, Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Organelle biogenesis and maintenance, Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
UniProt: Q8BFY9
Entrez ID: 238799
|
Does Knockout of Bcas2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Bcas2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Bcas2 (BCAS2 pre-mRNA processing factor)
Type: protein-coding
Summary: Acts upstream of or within several processes, including alternative mRNA splicing, via spliceosome; ovarian follicle development; and spindle assembly. Part of Prp19 complex. Is expressed in several structures, including central nervous system; early conceptus; oocyte; peripheral nervous system ganglion; and submandibular gland primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, oocyte development, oogenesis, ovarian follicle development, protein catabolic process, spindle assembly; CC: DNA replication factor A complex, Prp19 complex, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, centrosome, nuclear speck, nucleolus, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9D287
Entrez ID: 68183
|
Does Knockout of Tut1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Tut1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tut1 (terminal uridylyl transferase 1, U6 snRNA-specific)
Type: protein-coding
Summary: Predicted to enable several functions, including RNA binding activity; enzyme-substrate adaptor activity; and nucleotidyltransferase activity. Predicted to be involved in U6 snRNA 3'-end processing and co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway. Predicted to be located in cytosol and nucleolus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in nuclear speck. Is expressed in central nervous system; genitourinary system; and sensory organ. Orthologous to human TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: RNA 3'-end processing, RNA metabolic process, U6 snRNA 3'-end processing, co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, histone mRNA catabolic process, mRNA 3'-end processing, mRNA processing, regulation of RNA metabolic process, snRNA processing; MF: ATP binding, RNA binding, RNA uridylyltransferase activity, U6 snRNA binding, enzyme binding, enzyme-substrate adaptor activity, mRNA 3'-UTR binding, metal ion binding, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, poly(A) RNA polymerase activity, transferase activity, zinc ion binding; CC: cytosol, mRNA cleavage and polyadenylation specificity factor complex, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8R3F9
Entrez ID: 70044
|
Does Knockout of C1qtnf7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
C1qtnf7
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: C1qtnf7 (C1q and tumor necrosis factor related protein 7)
Type: protein-coding
Summary: Enables identical protein binding activity. Located in extracellular space. Is expressed in several structures, including adipose tissue; central nervous system; genitourinary system; gut; and skeleton. Orthologous to human C1QTNF7 (C1q and TNF related 7). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: identical protein binding, protein binding; CC: collagen trimer, extracellular region, extracellular space
Pathways:
UniProt: Q8BVD7
Entrez ID: 109323
|
Does Knockout of Gm4775 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Gm4775
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gm4775 (predicted gene 4775)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 212084
|
Does Knockout of Rabgef1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rabgef1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rabgef1 (RAB guanine nucleotide exchange factor (GEF) 1)
Type: protein-coding
Summary: Enables ubiquitin protein ligase activity. Involved in dendritic transport. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Located in vesicle. Is expressed in genitourinary system; hippocampus; and retina nuclear layer. Orthologous to human RABGEF1 (RAB guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: dendritic transport, endocytosis, endosomal transport, establishment of localization in cell, mast cell migration, negative regulation of Kit signaling pathway, negative regulation of Ras protein signal transduction, negative regulation of inflammatory response, negative regulation of interleukin-6 production, negative regulation of leukocyte migration, negative regulation of mast cell activation, negative regulation of mast cell cytokine production, negative regulation of mast cell degranulation, negative regulation of receptor-mediated endocytosis, protein targeting to membrane, protein transport, regulation of Fc receptor mediated stimulatory signaling pathway, vesicle-mediated transport; MF: DNA binding, guanyl-nucleotide exchange factor activity, metal ion binding, protein binding, small GTPase binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytosol, dendrite, early endosome, early endosome membrane, endocytic vesicle, endosome, nucleolus, presynaptic endosome, recycling endosome, vesicle
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q9JM13
Entrez ID: 56715
|
Does Knockout of Crls1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Crls1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Crls1 (cardiolipin synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiolipin biosynthetic process, lipid metabolic process, phospholipid biosynthetic process, response to phosphatidylethanolamine, response to thyroxine; MF: cardiolipin synthase (CMP-forming), phosphotransferase activity, for other substituted phosphate groups, transferase activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways: Acyl chain remodelling of PG, Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of CL, cardiolipin biosynthesis I, phospholipid biosynthesis I
UniProt: Q80ZM8
Entrez ID: 66586
|
Does Knockout of Pecam1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Pecam1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Pecam1 (platelet/endothelial cell adhesion molecule 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, angiogenesis, bicellular tight junction assembly, blood vessel development, cell adhesion, cell migration, cell surface receptor signaling pathway, cell-cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, cellular response to mechanical stimulus, detection of mechanical stimulus, diapedesis, endothelial cell development, endothelial cell migration, endothelial cell morphogenesis, endothelial cell-matrix adhesion, establishment of endothelial barrier, glomerular endothelium development, homophilic cell adhesion via plasma membrane adhesion molecules, immune response, leukocyte cell-cell adhesion, monocyte extravasation, negative regulation of actin filament polymerization, neutrophil extravasation, phagocytosis, positive regulation of MAPK cascade, positive regulation of cell migration, positive regulation of cellular extravasation, positive regulation of intracellular signal transduction, positive regulation of leukocyte migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to cell-cell junction, regulation of cell migration, signal transduction, vasodilation, wound healing; MF: protein binding, protein homodimerization activity, protein phosphatase binding, transmembrane signaling receptor activity; CC: anchoring junction, cell periphery, cell surface, cell-cell contact zone, cell-cell junction, cytoplasm, cytosol, external side of plasma membrane, extracellular space, membrane, membrane raft, nucleolus, nucleoplasm, plasma membrane, protein-containing complex, ruffle, smooth muscle contractile fiber
Pathways: Cell adhesion molecules - Mus musculus (mouse), Cell surface interactions at the vascular wall, Extracellular matrix organization, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hemostasis, Immune System, Innate Immune System, Integrin cell surface interactions, Leukocyte transendothelial migration - Mus musculus (mouse), Malaria - Mus musculus (mouse), Neutrophil degranulation, PECAM1 interactions, Platelet activation, signaling and aggregation, Platelet degranulation , Platelet homeostasis, Platelet sensitization by LDL, Response to elevated platelet cytosolic Ca2+
UniProt: Q08481
Entrez ID: 18613
|
Does Knockout of Timm17a in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Timm17a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Timm17a (translocase of inner mitochondrial membrane 17a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of protein processing, protein import into mitochondrial matrix, protein transport; MF: enzyme binding, protein transmembrane transporter activity; CC: TIM23 mitochondrial import inner membrane translocase complex, membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm
Pathways:
UniProt: Q9Z0V8
Entrez ID: 21854
|
Does Knockout of Ubqln1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 2,173
|
Knockout
|
Ubqln1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ubqln1 (ubiquilin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, aggrephagy, autophagosome assembly, autophagosome maturation, autophagy, cellular response to hypoxia, macroautophagy, negative regulation of store-operated calcium channel activity, negative regulation of toll-like receptor 3 signaling pathway, positive regulation of ERAD pathway, positive regulation of protein ubiquitination, regulation of macroautophagy, regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, regulation of protein ubiquitination, response to endoplasmic reticulum stress, ubiquitin-dependent protein catabolic process; MF: identical protein binding, intermediate filament binding, kinase binding, polyubiquitin modification-dependent protein binding, protein domain specific binding, signaling receptor binding; CC: aggresome, autophagosome, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, proteasome complex, protein-containing complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q8R317
Entrez ID: 56085
|
Does Knockout of Pkig in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Pkig
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pkig (protein kinase inhibitor, gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of protein import into nucleus, negative regulation of transcription by RNA polymerase II; MF: cAMP-dependent protein kinase inhibitor activity, protein kinase inhibitor activity; CC: cytoplasm, nucleus
Pathways:
UniProt: O70139
Entrez ID: 18769
|
Does Knockout of Nkx2-5 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Nkx2-5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nkx2-5 (NK2 homeobox 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Purkinje myocyte differentiation, adult heart development, apoptotic process involved in heart morphogenesis, atrial cardiac muscle cell development, atrial cardiac muscle tissue development, atrial septum morphogenesis, atrioventricular node cell development, atrioventricular node cell fate commitment, atrioventricular node development, bundle of His development, cardiac conduction system development, cardiac muscle cell development, cardiac muscle cell differentiation, cardiac muscle cell proliferation, cardiac muscle contraction, cardiac muscle tissue development, cardiac muscle tissue morphogenesis, cardiac septum morphogenesis, cardiac ventricle formation, cardiac ventricle morphogenesis, cell differentiation, embryonic heart tube development, embryonic heart tube left/right pattern formation, endoderm development, epithelial cell differentiation, heart contraction, heart development, heart looping, heart morphogenesis, heart trabecula formation, hemopoiesis, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle cell apoptotic process, negative regulation of epithelial cell apoptotic process, negative regulation of myotube differentiation, negative regulation of transcription by RNA polymerase II, outflow tract morphogenesis, outflow tract septum morphogenesis, pharyngeal system development, positive regulation of DNA-templated transcription, positive regulation of cardioblast differentiation, positive regulation of epithelial cell proliferation, positive regulation of gene expression, positive regulation of heart contraction, positive regulation of neuron differentiation, positive regulation of sodium ion transport, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, proepicardium development, pulmonary myocardium development, regulation of DNA-templated transcription, regulation of cardiac conduction, regulation of cardiac muscle cell proliferation, regulation of cardiac muscle contraction, regulation of transcription by RNA polymerase II, right ventricular cardiac muscle tissue morphogenesis, septum secundum development, spleen development, thyroid gland development, tongue development, vasculogenesis, ventricular cardiac muscle cell development, ventricular cardiac myofibril assembly, ventricular septum morphogenesis, ventricular trabecula myocardium morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, histone deacetylase binding, identical protein binding, protein binding, protein homodimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: Nkx-2.5 complex, RNA polymerase II transcription regulator complex, cytoplasm, cytosol, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, transcription regulator complex
Pathways:
UniProt: P42582
Entrez ID: 18091
|
Does Knockout of Lmcd1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Lmcd1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lmcd1 (LIM and cysteine-rich domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of calcineurin-NFAT signaling cascade, regulation of cardiac muscle hypertrophy; MF: metal ion binding, protein binding, transcription corepressor activity, zinc ion binding; CC: cytoplasm, nucleus
Pathways: Metabolism of proteins, Surfactant metabolism
UniProt: Q8VEE1
Entrez ID: 30937
|
Does Knockout of Arhgap22 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Arhgap22
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Arhgap22 (Rho GTPase activating protein 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell differentiation, negative regulation of small GTPase mediated signal transduction, regulation of postsynapse organization, regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity; CC: cytoplasm, glutamatergic synapse, nucleus
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BL80
Entrez ID: 239027
|
Does Knockout of Slc16a5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Slc16a5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc16a5 (solute carrier family 16 (monocarboxylic acid transporters), member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monocarboxylic acid transport, transmembrane transport; MF: monocarboxylic acid transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways:
UniProt: G5E8K6
Entrez ID: 217316
|
Does Knockout of Sf3b6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Sf3b6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sf3b6 (splicing factor 3B, subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, blastocyst formation, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding; CC: U12-type spliceosomal complex, U2-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Spliceosome - Mus musculus (mouse)
UniProt: P59708
Entrez ID: 66055
|
Does Knockout of Zfp524 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Zfp524
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp524 (zinc finger protein 524)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: Q9D0B1
Entrez ID: 66056
|
Does Knockout of Slc17a8 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Slc17a8
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Slc17a8 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamate import, L-glutamate transmembrane transport, chloride transmembrane transport, chloride transport, cochlea development, monoatomic ion transmembrane transport, monoatomic ion transport, neural retina development, neurotransmitter loading into synaptic vesicle, neurotransmitter transport, phosphate ion homeostasis, phosphate ion transport, positive regulation of glutamate uptake involved in transmission of nerve impulse, regulation of acetylcholine uptake, regulation of synapse structure or activity, sensory perception of sound, sodium ion transmembrane transport, sodium ion transport, sodium-dependent phosphate transport, synaptic transmission, glutamatergic, transmembrane transport; MF: L-glutamate transmembrane transporter activity, L-glutamate uniporter activity, chloride channel activity, neurotransmitter transmembrane transporter activity, sodium:phosphate symporter activity, symporter activity, transmembrane transporter activity; CC: apical dendrite, axon terminus, basal dendrite, chloride channel complex, clathrin-sculpted glutamate transport vesicle membrane, cytoplasmic vesicle, dendrite, excitatory synapse, glial limiting end-foot, glutamatergic synapse, membrane, multivesicular body, neuron projection, neuronal cell body, pericellular basket, perikaryon, plasma membrane, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways: Glutamatergic synapse - Mus musculus (mouse), Nicotine addiction - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Synaptic vesicle cycle - Mus musculus (mouse), Transport of small molecules
UniProt: Q8BFU8
Entrez ID: 216227
|
Does Knockout of Prtn3 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Prtn3
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Prtn3 (proteinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-cell junction maintenance, collagen catabolic process, mature conventional dendritic cell differentiation, membrane protein ectodomain proteolysis, negative regulation of phagocytosis, neutrophil extravasation, proteolysis; MF: enzyme binding, hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity, signaling receptor binding; CC: azurophil granule lumen, cytoplasm, cytosol, extracellular region, extracellular space, lysosome, membrane, membrane raft, plasma membrane, plasma membrane raft
Pathways: Antimicrobial peptides, Common Pathway of Fibrin Clot Formation, Formation of Fibrin Clot (Clotting Cascade), Hemostasis, Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q61096
Entrez ID: 19152
|
Does Knockout of Hsp90b1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Hsp90b1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Hsp90b1 (heat shock protein 90, beta (Grp94), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, actin rod assembly, cellular response to ATP, cellular response to manganese ion, insulin processing, negative regulation of apoptotic process, positive regulation of Wnt signaling pathway, positive regulation of toll-like receptor signaling pathway, protein folding, protein localization to plasma membrane, response to hypoxia, retrograde protein transport, ER to cytosol; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, RNA binding, hydrolase activity, low-density lipoprotein particle receptor binding, nucleotide binding, protein binding, protein folding chaperone, protein phosphatase binding, protein phosphatase inhibitor activity, unfolded protein binding; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, endoplasmic reticulum membrane, extracellular region, melanosome, midbody, perinuclear region of cytoplasm, protein-containing complex, sarcoplasmic reticulum, sarcoplasmic reticulum lumen, smooth endoplasmic reticulum, sperm plasma membrane
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cytokine Signaling in Immune system, Estrogen signaling pathway - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-4 and Interleukin-13 signaling, Lipid and atherosclerosis - Mus musculus (mouse), Metabolism of proteins, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Post-translational protein phosphorylation, Prostate cancer - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Salmonella infection - Mus musculus (mouse), Scavenging by Class A Receptors, Signaling by Interleukins, Thyroid hormone synthesis - Mus musculus (mouse), Toll-like Receptor Cascades, Trafficking and processing of endosomal TLR, Vesicle-mediated transport
UniProt: P08113
Entrez ID: 22027
|
Does Knockout of Srpk3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Srpk3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Srpk3 (serine/arginine-rich protein specific kinase 3)
Type: protein-coding
Summary: Enables protein serine/threonine kinase activity. Involved in muscle tissue development. Acts upstream of or within protein phosphorylation and skeletal muscle tissue development. Predicted to be active in cytoplasm and nucleus. Is expressed in tail mesenchyme; tongue; and vertebral axis musculature. Orthologous to human SRPK3 (SRSF protein kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, intracellular signal transduction, muscle organ development, muscle tissue development, regulation of mRNA processing, skeletal muscle tissue development, spliceosomal complex assembly; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9Z0G2
Entrez ID: 56504
|
Does Knockout of Nbeal2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Nbeal2
|
response to virus
|
Microglial Cell Line
|
Gene: Nbeal2 (neurobeachin-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood coagulation, intracellular protein localization, megakaryocyte development, myeloid cell differentiation, platelet alpha granule organization, platelet formation, wound healing; CC: cytosol, endoplasmic reticulum, membrane
Pathways:
UniProt: Q6ZQA0
Entrez ID: 235627
|
Does Knockout of Pmpcb in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Pmpcb
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pmpcb (peptidase (mitochondrial processing) beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein processing, protein processing involved in protein targeting to mitochondrion, proteolysis; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity; CC: catalytic complex, mitochondrial inner membrane, mitochondrial matrix, mitochondrial processing peptidase complex, mitochondrion
Pathways: Mitochondrial calcium ion transport, Processing of SMDT1, Transport of small molecules
UniProt: Q9CXT8
Entrez ID: 73078
|
Does Knockout of Zdhhc4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Zdhhc4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zdhhc4 (zinc finger, DHHC domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic pattern recognition receptor signaling pathway, negative regulation of cell migration, positive regulation of cell migration, positive regulation of innate immune response, protein localization to plasma membrane, protein targeting to membrane; MF: acyltransferase activity, palmitoyltransferase activity, protein-cysteine S-palmitoyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q9D6H5
Entrez ID: 72881
|
Does Knockout of Defb7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Defb7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Defb7 (defensin beta 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, defense response, defense response to bacterium, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity, phosphatidylinositol-4,5-bisphosphate binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q91V70
Entrez ID: 246080
|
Does Knockout of Npat in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Npat
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Npat (nuclear protein in the AT region)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell cycle G1/S phase transition, in utero embryonic development, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II; MF: transcription coactivator activity, transcription coregulator activity, transcription corepressor activity; CC: Cajal body, Gemini of Cajal bodies, cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q8BMA5
Entrez ID: 244879
|
Does Knockout of Brd8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Brd8
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Brd8 (bromodomain containing 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to thyroid hormone stimulus, chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of transcription by RNA polymerase II, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair; MF: nuclear thyroid hormone receptor binding, transcription coactivator activity; CC: NuA4 histone acetyltransferase complex, Swr1 complex, mitochondrion, nucleoplasm, nucleosome, nucleus
Pathways:
UniProt: Q8R3B7
Entrez ID: 78656
|
Does Knockout of Fut7 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Fut7
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Fut7 (fucosyltransferase 7)
Type: protein-coding
Summary: Enables alpha-(1->3)-fucosyltransferase activity. Involved in several processes, including leukocyte migration involved in inflammatory response; lymphocyte migration into lymph node; and regulation of leukocyte migration. Acts upstream of or within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; T cell migration; and leukocyte migration involved in immune response. Predicted to be located in trans-Golgi network. Orthologous to human FUT7 (fucosyltransferase 7). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, T cell migration, ceramide metabolic process, embryo implantation, fucosylation, inflammatory response, leukocyte migration involved in immune response, leukocyte migration involved in inflammatory response, lymphocyte migration into lymph node, lymphocyte migration into lymphoid organs, positive regulation of cell adhesion, positive regulation of cell-cell adhesion, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of leukocyte tethering or rolling, positive regulation of neutrophil migration, protein glycosylation, regulation of cell adhesion molecule production, regulation of cell-cell adhesion, regulation of insulin receptor signaling pathway, regulation of leukocyte adhesion to vascular endothelial cell, regulation of leukocyte cell-cell adhesion, regulation of leukocyte tethering or rolling, regulation of neutrophil extravasation, regulation of type IV hypersensitivity; MF: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity, alpha-(1->3)-fucosyltransferase activity, fucosyltransferase activity, glycosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, membrane, trans-Golgi network
Pathways: Blood group systems biosynthesis, Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q11131
Entrez ID: 14347
|
Does Knockout of Taf1a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Taf1a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Taf1a (TATA-box binding protein associated factor, RNA polymerase I, A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transcription by RNA polymerase I; MF: DNA binding, protein binding; CC: RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, microtubule cytoskeleton, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination
UniProt: P97357
Entrez ID: 21339
|
Does Knockout of Rer1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Rer1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rer1 (retention in endoplasmic reticulum sorting receptor 1)
Type: protein-coding
Summary: Enables acetylcholine receptor binding activity. Acts upstream of or within positive regulation of protein localization to plasma membrane and skeletal muscle acetylcholine-gated channel clustering. Located in cell surface and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human RER1 (retention in endoplasmic reticulum sorting receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: neuromuscular junction development, positive regulation of protein localization to plasma membrane, protein retention in ER lumen, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, skeletal muscle acetylcholine-gated channel clustering; CC: Golgi apparatus, Golgi membrane, cell surface, cytoplasm, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, membrane, plasma membrane
Pathways:
UniProt: Q9CQU3
Entrez ID: 67830
|
Does Knockout of Ywhae in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,531
|
Knockout
|
Ywhae
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Ywhae (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, MAPK cascade, cellular response to heat, cerebral cortex development, cytoplasmic pattern recognition receptor signaling pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of protein localization, hippo signaling, hippocampus development, intracellular potassium ion homeostasis, intracellular protein localization, negative regulation of calcium ion export across plasma membrane, negative regulation of toll-like receptor signaling pathway, neuron migration, positive regulation of hippo signaling, positive regulation of protein export from nucleus, positive regulation of toll-like receptor signaling pathway, protein K11-linked ubiquitination, protein localization to endoplasmic reticulum, protein localization to nucleus, protein targeting, regulation of cytosolic calcium ion concentration, regulation of membrane repolarization, regulation of mitotic cell cycle, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of potassium ion transmembrane transport, signal transduction, toll-like receptor 4 signaling pathway; MF: calcium channel inhibitor activity, calcium channel regulator activity, enzyme binding, enzyme inhibitor activity, histone deacetylase binding, identical protein binding, phosphoprotein binding, phosphoserine residue binding, potassium channel regulator activity, protein binding, protein domain specific binding, protein heterodimerization activity, protein phosphatase binding, protein phosphatase inhibitor activity, protein sequestering activity, protein-containing complex binding, scaffold protein binding, signaling adaptor activity, transmembrane transporter binding, ubiquitin protein ligase binding; CC: axon, central region of growth cone, cytoplasm, cytosol, endoplasmic reticulum, glutamatergic synapse, kinesin complex, melanosome, mitochondrion, nucleus, plasma membrane, synapse
Pathways: AURKA Activation by TPX2, Activation of BAD and translocation to mitochondria , Activation of BH3-only proteins, Anchoring of the basal body to the plasma membrane, Apoptosis, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cell death signalling via NRAGE, NRIF and NADE, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Cilium Assembly, Death Receptor Signaling, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, HSF1 activation, Hepatitis C - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Intrinsic Pathway for Apoptosis, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Membrane Trafficking, Mitotic G2-G2/M phases, Mitotic Prometaphase, NADE modulates death signalling, NOD-like receptor signaling pathway - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Organelle biogenesis and maintenance, PI3K-Akt signaling pathway - Mus musculus (mouse), Programmed Cell Death, RAB GEFs exchange GTP for GDP on RABs, RHO GTPase Effectors, RHO GTPases activate PKNs, RNA Polymerase II Transcription, Rab regulation of trafficking, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of HSF1-mediated heat shock response, Regulation of PLK1 Activity at G2/M Transition, Signal Transduction, Signaling by Hippo, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, Vesicle-mediated transport, Viral carcinogenesis - Mus musculus (mouse), p75 NTR receptor-mediated signalling
UniProt: P62259
Entrez ID: 22627
|
Does Knockout of Egr1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Egr1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Egr1 (early growth response 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, T cell differentiation, cellular response to gamma radiation, cellular response to heparin, cellular response to hypoxia, cellular response to interleukin-8, cellular response to mycophenolic acid, circadian regulation of gene expression, circadian temperature homeostasis, estrous cycle, glomerular mesangial cell proliferation, interleukin-1-mediated signaling pathway, learning or memory, locomotor rhythm, long-term memory, negative regulation of canonical Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of chemokine production, positive regulation of gene expression, positive regulation of gene expression via chromosomal CpG island demethylation, positive regulation of glomerular metanephric mesangial cell proliferation, positive regulation of hormone biosynthetic process, positive regulation of interleukin-1 beta production, positive regulation of miRNA transcription, positive regulation of neuron apoptotic process, positive regulation of post-translational protein modification, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of long-term neuronal synaptic plasticity, regulation of neuron apoptotic process, regulation of progesterone biosynthetic process, regulation of protein sumoylation, regulation of transcription by RNA polymerase II, response to glucose, response to hypoxia, response to insulin, response to ischemia, rhythmic process, skeletal muscle cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, double-stranded methylated DNA binding, enzyme binding, hemi-methylated DNA-binding, histone acetyltransferase binding, metal ion binding, promoter-specific chromatin binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Prion disease - Mus musculus (mouse)
UniProt: P08046
Entrez ID: 13653
|
Does Knockout of Clpx in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Clpx
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Clpx (caseinolytic mitochondrial matrix peptidase chaperone subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, protein folding, proteolysis, proteolysis involved in protein catabolic process; MF: ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, peptidase activator activity, protein binding, protein dimerization activity, unfolded protein binding, zinc ion binding; CC: cytosol, endopeptidase Clp complex, mitochondrial endopeptidase Clp complex, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleoplasm
Pathways: Metabolism of proteins, Mitochondrial protein degradation
UniProt: Q9JHS4
Entrez ID: 270166
|
Does Knockout of Serpina1a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Serpina1a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Serpina1a (serine (or cysteine) peptidase inhibitor, clade A, member 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acute-phase response, protein N-linked glycosylation, response to chromate, response to cytokine, response to lead ion, response to methanol, response to peptide hormone; MF: endopeptidase inhibitor activity, identical protein binding, peptidase inhibitor activity, protease binding, protein binding, serine-type endopeptidase inhibitor activity; CC: Golgi apparatus, endoplasmic reticulum, extracellular matrix, extracellular region, extracellular space
Pathways: Complement and coagulation cascades - Mus musculus (mouse)
UniProt: P07758
Entrez ID: 20700
|
Does Knockout of Mgat3 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Mgat3
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Mgat3 (mannoside acetylglucosaminyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-acetylglucosamine metabolic process, amyloid-beta metabolic process, cellular response to oxidative stress, cognition, intracellular protein localization, negative regulation of lysosomal protein catabolic process, positive regulation of protein localization to early endosome, protein N-linked glycosylation, protein glycosylation, regulation of cell migration; MF: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity, glycosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, lysosome, membrane
Pathways: N-Glycan biosynthesis - Mus musculus (mouse)
UniProt: Q5RKT9
Entrez ID: 17309
|
Does Knockout of Gsg1l in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Gsg1l
|
response to virus
|
Microglial Cell Line
|
Gene: Gsg1l (GSG1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of cell communication, regulation of postsynaptic neurotransmitter receptor internalization, regulation of short-term neuronal synaptic plasticity, regulation of signaling, regulation of transport, synapse organization, transmission of nerve impulse; CC: Schaffer collateral - CA1 synapse, asymmetric synapse, glutamatergic synapse, membrane, plasma membrane, postsynaptic density membrane, synapse
Pathways:
UniProt: D3Z7H4
Entrez ID: 269994
|
Does Knockout of Pkdcc in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Pkdcc
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Pkdcc (protein kinase domain containing, cytoplasmic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, cell differentiation, embryonic digestive tract development, limb morphogenesis, lung alveolus development, multicellular organism growth, negative regulation of Golgi to plasma membrane protein transport, ossification, peptidyl-tyrosine phosphorylation, positive regulation of bone mineralization, positive regulation of chondrocyte differentiation, protein transport, roof of mouth development, skeletal system development; MF: ATP binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, transferase activity; CC: Golgi apparatus, extracellular region
Pathways:
UniProt: Q5RJI4
Entrez ID: 106522
|
Does Knockout of Arhgap8 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Arhgap8
|
cell proliferation
|
Regulatory T cell
|
Gene: Arhgap8 (Rho GTPase activating protein 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of endocytic recycling, positive regulation of ERK1 and ERK2 cascade, signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity; CC: cytoplasm, membrane, plasma membrane bounded cell projection
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CXP4
Entrez ID: 73167
|
Does Knockout of Ufl1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Ufl1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ufl1 (UFM1 specific ligase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA double-strand break processing, DNA repair, NLRP3 inflammasome complex assembly, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, antiviral innate immune response, double-strand break repair via homologous recombination, erythrocyte differentiation, hematopoietic stem cell differentiation, negative regulation of IRE1-mediated unfolded protein response, negative regulation of NF-kappaB transcription factor activity, negative regulation of T cell activation, negative regulation of T cell mediated immune response to tumor cell, negative regulation of apoptotic process, negative regulation of protein ubiquitination, negative regulation of signal transduction by p53 class mediator, positive regulation of T cell activation, positive regulation of T cell mediated immune response to tumor cell, positive regulation of autophagy, positive regulation of cell population proliferation, positive regulation of glial cell proliferation, positive regulation of proteolysis involved in protein catabolic process, positive regulation of reticulophagy, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K69-linked ufmylation, protein stabilization, protein ufmylation, regulation of canonical NF-kappaB signal transduction, regulation of gene expression, regulation of inflammatory response, regulation of intracellular estrogen receptor signaling pathway, regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of protein localization, rescue of stalled ribosome, response to L-glutamate, response to endoplasmic reticulum stress, reticulophagy, ribosome disassembly; MF: UFM1 ligase activity, UFM1 transferase activity, protein binding, protein kinase binding, transferase activity; CC: chromosome, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, neuron projection, nucleus, protein-containing complex, site of double-strand break
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q8CCJ3
Entrez ID: 67490
|
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