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Does Knockout of Prrc2a in Immortal mouse chromaffin cells causally result in cell viability?
1
2,469
Knockout
Prrc2a
cell viability
Immortal mouse chromaffin cells
Gene: Prrc2a (proline-rich coiled-coil 2A) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane Pathways: UniProt: Q7TSC1 Entrez ID: 53761
Does Knockout of Ackr1 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Ackr1
protein/peptide accumulation
Embryonic Cell Line
Gene: Ackr1 (atypical chemokine receptor 1 (Duffy blood group)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, chemokine-mediated signaling pathway, inflammatory response, regulation of chemokine production, signal transducti...
Does Knockout of Mmp17 in Immortal mouse chromaffin cells causally result in cell viability?
1
2,469
Knockout
Mmp17
cell viability
Immortal mouse chromaffin cells
Gene: Mmp17 (matrix metallopeptidase 17) Type: protein-coding Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded prepropr...
Does Knockout of Dpep2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,290
Knockout
Dpep2
cell proliferation
Mouse kidney carcinoma cell
Gene: Dpep2 (dipeptidase 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: leukotriene D4 catabolic process, leukotriene metabolic process, lipid metabolic process, proteolysis; MF: dipeptidase activity, exopeptidase activity, hydrolase activity, metal ion binding, metal...
Does Knockout of Phf24 in Embryonic Stem Cell Line causally result in cell proliferation?
0
579
Knockout
Phf24
cell proliferation
Embryonic Stem Cell Line
Gene: Phf24 (PHD finger protein 24) Type: protein-coding Summary: No summary available. Gene Ontology: BP: detection of mechanical stimulus involved in sensory perception of pain, gamma-aminobutyric acid signaling pathway, negative regulation of DNA-templated transcription, regulation of G prot...
Does Knockout of Rbm44 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,278
Knockout
Rbm44
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Rbm44 (RNA binding motif protein 44) Type: protein-coding Summary: No summary available. Gene Ontology: MF: RNA binding, mRNA 3'-UTR binding, nucleic acid binding, protein binding, protein homodimerization activity; CC: catalytic step 2 spliceosome, cytoplasm, intercellular bridge ...
Does Knockout of Moxd1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
165
Knockout
Moxd1
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Moxd1 (monooxygenase, DBH-like 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: dopamine catabolic process, norepinephrine biosynthetic process, octopamine biosynthetic process; MF: catalytic activity, copper ion binding, dopamine beta-monooxygenase activity, meta...
Does Knockout of D630033O11Rik in myoblast cell line causally result in protein/peptide distribution?
1
1,684
Knockout
D630033O11Rik
protein/peptide distribution
myoblast cell line
Gene: D630033O11Rik (RIKEN cDNA D630033O11 gene) Type: Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID:
Does Knockout of Cenpt in Embryonic Stem Cell Line causally result in cell proliferation?
0
579
Knockout
Cenpt
cell proliferation
Embryonic Stem Cell Line
Gene: Cenpt (centromere protein T) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell division, chromosome organization, chromosome segregation, kinetochore assembly, mitotic cell cycle; MF: DNA binding, protein heterodimerization activity; CC: chromosome, chromosome, c...
Does Knockout of Abl1 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Abl1
phagocytosis
macrophage
Gene: Abl1 (c-abl oncogene 1, non-receptor tyrosine kinase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: B cell proliferation, B cell proliferation involved in immune response, B cell receptor signaling pathway, B-1 B cell homeostasis, Bergmann glial cell differentiati...
Does Knockout of Ubr3 in myoblast cell line causally result in protein/peptide distribution?
1
1,682
Knockout
Ubr3
protein/peptide distribution
myoblast cell line
Gene: Ubr3 (ubiquitin protein ligase E3 component n-recognin 3) Type: protein-coding Summary: Enables ubiquitin protein ligase activity. Involved in several processes, including sensory perception of smell; suckling behavior; and ubiquitin-dependent protein catabolic process. Acts upstream of or within ...
Does Activation of Arl2 in Mouse cell causally result in protein/peptide accumulation?
1
690
Activation
Arl2
protein/peptide accumulation
Mouse cell
Gene: Arl2 (ADP-ribosylation factor-like 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: acetylcholine transport, bicellular tight junction assembly, centrosome cycle, maintenance of protein location in nucleus, negative regulation of GTPase activity, positive regulati...
Does Knockout of Lrrc17 in myoblast cell line causally result in protein/peptide distribution?
1
1,684
Knockout
Lrrc17
protein/peptide distribution
myoblast cell line
Gene: Lrrc17 (leucine rich repeat containing 17) Type: protein-coding Summary: No summary available. Gene Ontology: BP: bone marrow development, negative regulation of osteoclast differentiation, ossification, osteoblast differentiation, osteoblast proliferation; MF: molecular_function, signali...
Does Knockout of Plch2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,271
Knockout
Plch2
cell proliferation
Mouse kidney carcinoma cell
Gene: Plch2 (phospholipase C, eta 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: intracellular signal transduction, lipid catabolic process, lipid metabolic process, phosphatidylinositol metabolic process, phosphatidylinositol-mediated signaling, phospholipase C-activ...
Does Knockout of Reg3d in Mouse cell causally result in protein/peptide accumulation?
0
1,047
Knockout
Reg3d
protein/peptide accumulation
Mouse cell
Gene: Reg3d (regenerating islet-derived 3 delta) Type: protein-coding Summary: Predicted to enable oligosaccharide binding activity; peptidoglycan binding activity; and signaling receptor activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide; posit...
Does Knockout of Rab33b in myoblast cell line causally result in protein/peptide distribution?
1
1,681
Knockout
Rab33b
protein/peptide distribution
myoblast cell line
Gene: Rab33b (RAB33B, member RAS oncogene family) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Rab protein signal transduction, autophagosome assembly, autophagy, intra-Golgi vesicle-mediated transport, negative regulation of constitutive secretory pathway, protein loc...
Does Knockout of Miga1 in breast epithelium causally result in cell cycle progression?
0
1,470
Knockout
Miga1
cell cycle progression
breast epithelium
Gene: Miga1 (mitoguardin 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: mitochondrial fusion; MF: protein heterodimerization activity, protein homodimerization activity; CC: membrane, mitochondrial outer membrane, mitochondrion, plasma membrane Pathways: Glyc...
Does Knockout of Tsfm in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
83
Knockout
Tsfm
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Tsfm (Ts translation elongation factor, mitochondrial) Type: protein-coding Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation and regulation of mitochondrial translation. Located in mitochondrion. Human ortholog(...
Does Knockout of Exosc3 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
1
684
Knockout
Exosc3
cell proliferation
Acute Myeloid Leukemia Cell Line
Gene: Exosc3 (exosome component 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: CUT catabolic process, DNA deamination, DNA metabolic process, RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, U4 snRNA 3'-end processing, exonucleolytic t...
Does Knockout of Usp51 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
161
Knockout
Usp51
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Usp51 (ubiquitin specific protease 51) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, protein deubiquitination, proteolysis, regulation of cell cycle process, regulation of double-strand br...
Does Knockout of Snrnp70 in Melanoma Cell Line causally result in cell proliferation?
1
1,270
Knockout
Snrnp70
cell proliferation
Melanoma Cell Line
Gene: Snrnp70 (small nuclear ribonucleoprotein 70 (U1)) Type: protein-coding Summary: This gene encodes a subunit of the U1 snRNP (small nuclear ribonucleic particle), one of at least five snRNPs to comprise the spliceosome, which functions in processing of pre-mRNAs. The U1 snRNP has been shown to be i...
Does Knockout of Drap1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
81
Knockout
Drap1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Drap1 (DR1 associated protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, RNA p...
Does Knockout of Mgat1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
83
Knockout
Mgat1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Mgat1 (mannoside acetylglucosaminyltransferase 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: UDP-N-acetylglucosamine catabolic process, in utero embryonic development, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycos...
Does Knockout of Them7 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,273
Knockout
Them7
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Them7 (thioesterase superfamily member 7) Type: protein-coding Summary: No summary available. Gene Ontology: MF: fatty acyl-CoA hydrolase activity, molecular_function Pathways: UniProt: Q9DCP4 Entrez ID: 74088
Does Knockout of Med23 in Embryonic Stem Cell Line causally result in cell proliferation?
1
2,477
Knockout
Med23
cell proliferation
Embryonic Stem Cell Line
Gene: Med23 (mediator complex subunit 23) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of T cell extravasation, positive regulation of gene expression, positive regulation of transcription elongation...
Does Knockout of Slc17a9 in Embryonic Stem Cell Line causally result in cell proliferation?
0
578
Knockout
Slc17a9
cell proliferation
Embryonic Stem Cell Line
Gene: Slc17a9 (solute carrier family 17, member 9) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ADP transport, ATP export, ATP transport, guanine nucleotide transmembrane transport, lysosomal protein catabolic process, purine nucleotide import into lysosome, purine-con...
Does Knockout of Vmn1r89 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,290
Knockout
Vmn1r89
cell proliferation
Mouse kidney carcinoma cell
Gene: Vmn1r89 (vomeronasal 1 receptor 89) Type: protein-coding Summary: Predicted to enable pheromone binding activity and pheromone receptor activity. Predicted to act upstream of or within response to pheromone. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr...
Does Knockout of Fam217b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
83
Knockout
Fam217b
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Fam217b (family with sequence similarity 217, member B) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cytosol, nucleoplasm Pathways: UniProt: A2AJW5 Entrez ID: 71532
Does Knockout of Ncoa6 in Embryonic Stem Cell Line causally result in cell proliferation?
0
2,477
Knockout
Ncoa6
cell proliferation
Embryonic Stem Cell Line
Gene: Ncoa6 (nuclear receptor coactivator 6) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA-templated transcription initiation, brain development, chromatin organization, heart development, labyrinthine layer blood vessel development, myeloid cel...
Does Knockout of Mrps15 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
1
1,267
Knockout
Mrps15
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Mrps15 (mitochondrial ribosomal protein S15) Type: protein-coding Summary: No summary available. Gene Ontology: BP: mitochondrial translation, translation; MF: protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrial riboso...
Does Knockout of Dynlrb1 in Microglial Cell Line causally result in protein/peptide distribution?
0
1,585
Knockout
Dynlrb1
protein/peptide distribution
Microglial Cell Line
Gene: Dynlrb1 (dynein light chain roadblock-type 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: microtubule-based movement, visual behavior; MF: dynein intermediate chain binding, identical protein binding, protein binding; CC: centrosome, cytoplasm, cytoplasmic dynei...
Does Knockout of Zmym6 in myoblast cell line causally result in protein/peptide distribution?
0
1,684
Knockout
Zmym6
protein/peptide distribution
myoblast cell line
Gene: Zmym6 (zinc finger, MYM-type 6) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cytoskeleton organization, regulation of cell morphogenesis Pathways: UniProt: A2A7U2, Q8BS54 Entrez ID: 100177
Does Knockout of Zc3h4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,262
Knockout
Zc3h4
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Zc3h4 (zinc finger CCCH-type containing 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA-templated transcription termination, lncRNA catabolic process, negative regulation of DNA-templated transcription, negative regulation of DNA-templated transcription, elon...
Does Knockout of Pon2 in Melanoma Cell Line causally result in cell proliferation?
0
1,270
Knockout
Pon2
cell proliferation
Melanoma Cell Line
Gene: Pon2 (paraoxonase 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: lactone catabolic process, response to toxic substance; MF: acyl-L-homoserine-lactone lactonohydrolase activity, arylesterase activity, hydrolase activity, metal ion binding, protein homodimerizati...
Does Knockout of Nipsnap3b in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,152
Knockout
Nipsnap3b
protein/peptide accumulation
Embryonic Cell Line
Gene: Nipsnap3b (nipsnap homolog 3B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: biological_process, mitophagy; CC: cytoplasm, cytosol, mitochondrion Pathways: UniProt: Q9CQE1 Entrez ID: 66536
Does Knockout of Zfp750 in myoblast cell line causally result in protein/peptide distribution?
0
1,679
Knockout
Zfp750
protein/peptide distribution
myoblast cell line
Gene: Zfp750 (zinc finger protein 750) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, epidermis development, establishment of skin barrier, membrane biogenesis, negative regulation of epithelial to mesenchymal transition, negative regulation of tran...
Does Knockout of Itk in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,171
Knockout
Itk
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Itk (IL2 inducible T cell kinase) Type: protein-coding Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including T cell receptor signaling pathway; gamma-delta T cell activation; and protein phosphorylation. Acts upstream of or wi...
Does Knockout of Snrnp70 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
1
1,265
Knockout
Snrnp70
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Snrnp70 (small nuclear ribonucleoprotein 70 (U1)) Type: protein-coding Summary: This gene encodes a subunit of the U1 snRNP (small nuclear ribonucleic particle), one of at least five snRNPs to comprise the spliceosome, which functions in processing of pre-mRNAs. The U1 snRNP has been shown to be i...
Does Knockout of Polh in Lymphoma Cell Line causally result in response to chemicals?
0
1,523
Knockout
Polh
response to chemicals
Lymphoma Cell Line
Gene: Polh (polymerase (DNA directed), eta (RAD 30 related)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA synthesis involved in DNA repair, cellular response to UV-C, error-prone translesio...
Does Knockout of Aamp in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,286
Knockout
Aamp
cell proliferation
Mouse kidney carcinoma cell
Gene: Aamp (angio-associated migratory protein) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cell surface, cytoplasm, intercellular bridge, microtubule cytoskeleton, plasma membrane Pathways: Hemostasis, Immune System, Innate Immune System, NOD1/2 Signaling Pa...
Does Knockout of Malt1 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Malt1
phagocytosis
macrophage
Gene: Malt1 (MALT1 paracaspase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: B cell activation, B-1 B cell differentiation, T cell proliferation, T cell receptor signaling pathway, apoptotic process, canonical NF-kappaB signal transduction, cell development, cellular r...
Does Knockout of Mapkapk2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,280
Knockout
Mapkapk2
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Mapkapk2 (MAP kinase-activated protein kinase 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, DNA damage response, MAPK cascade, cellular response to vascular endothelial growth factor stimulus, inflammatory response, inner ear...
Does Knockout of Swt1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
1,130
Knockout
Swt1
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Swt1 (SWT1 RNA endoribonuclease homolog (S. cerevisiae)) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q9DBQ9 Entrez ID: 66875
Does Knockout of Sppl2b in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
688
Knockout
Sppl2b
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Sppl2b (signal peptide peptidase like 2B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, membrane protein proteolysis, proteolysis, regulation of immune response; MF: aspart...
Does Knockout of Jun in Mammary Gland Tumor Cell Line causally result in cell proliferation?
1
1,273
Knockout
Jun
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Jun (jun proto-oncogene) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA-templated transcription, JNK cascade, SMAD protein signal transduction, angiogenesis, axon regeneration, cellular response to anisomycin, cellular response to calcium ion, cellular response...
Does Knockout of Pkm in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
1
1,262
Knockout
Pkm
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Pkm (pyruvate kinase, muscle) Type: protein-coding Summary: Enables mRNA binding activity and pyruvate kinase activity. Involved in canonical glycolysis and positive regulation of cytoplasmic translation. Located in cilium and rough endoplasmic reticulum. Is active in cytosol. Is expressed in seve...
Does Knockout of Srbd1 in myoblast cell line causally result in protein/peptide distribution?
0
1,684
Knockout
Srbd1
protein/peptide distribution
myoblast cell line
Gene: Srbd1 (S1 RNA binding domain 1) Type: protein-coding Summary: Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Is expressed in olfactory epithelium and thymus primordium. Orthologous to human SRBD1 (S1 RNA bin...
Does Knockout of Col7a1 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Col7a1
phagocytosis
macrophage
Gene: Col7a1 (collagen, type VII, alpha 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell adhesion, collagen fibril organization; MF: extracellular matrix structural constituent conferring tensile strength, identical protein binding, peptidase inhibitor activity, se...
Does Knockout of Vps16 in macrophage causally result in phagocytosis?
1
1,888
Knockout
Vps16
phagocytosis
macrophage
Gene: Vps16 (VSP16 CORVET/HOPS core subunit) Type: protein-coding Summary: No summary available. Gene Ontology: BP: autophagosome maturation, autophagy, endosomal transport, endosome to lysosome transport, intracellular protein transport, protein transport, symbiont entry into host cell, vacuol...
Does Knockout of Fgd1 in Embryonic Stem Cell Line causally result in cell proliferation?
0
2,477
Knockout
Fgd1
cell proliferation
Embryonic Stem Cell Line
Gene: Fgd1 (FYVE, RhoGEF and PH domain containing 1) Type: protein-coding Summary: This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as...
Does Knockout of Pik3c3 in Mouse kidney carcinoma cell causally result in cell proliferation?
1
1,288
Knockout
Pik3c3
cell proliferation
Mouse kidney carcinoma cell
Gene: Pik3c3 (phosphatidylinositol 3-kinase catalytic subunit type 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: autophagosome assembly, autophagosome maturation, autophagy, cell division, cellular response to glucose starvation, cellular response to starvation, earl...
Does Knockout of Mrps35 in Lymphoma Cell Line causally result in response to chemicals?
0
1,525
Knockout
Mrps35
response to chemicals
Lymphoma Cell Line
Gene: Mrps35 (mitochondrial ribosomal protein S35) Type: protein-coding Summary: No summary available. Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: cytosol, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucle...
Does Knockout of Spc25 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,286
Knockout
Spc25
cell proliferation
Mouse kidney carcinoma cell
Gene: Spc25 (SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)) Type: protein-coding Summary: This gene encodes a component of the kinetochore-associated NDC80 protein complex, which is required for the mitotic spindle checkpoint and for microtubule-kinetochore attachment. During meios...
Does Knockout of Wdr6 in myoblast cell line causally result in protein/peptide distribution?
1
1,682
Knockout
Wdr6
protein/peptide distribution
myoblast cell line
Gene: Wdr6 (WD repeat domain 6) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G1 to G0 transition, negative regulation of autophagy, negative regulation of cell population proliferation, tRNA methylation, tRNA processing, wobble position ribose methylation; MF: enzyme r...
Does Knockout of Adam1b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Adam1b
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Adam1b (a disintegrin and metallopeptidase domain 1b) Type: protein-coding Summary: No summary available. Gene Ontology: BP: binding of sperm to zona pellucida, male gonad development, proteolysis, spermatogenesis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, ...
Does Knockout of Mecr in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
1
1,267
Knockout
Mecr
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Mecr (mitochondrial trans-2-enoyl-CoA reductase) Type: protein-coding Summary: Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity; nuclear receptor binding activity; and signaling receptor binding activity. Predicted to be involved in fatty acid metabolic process. Located ...
Does Knockout of Nod2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
687
Knockout
Nod2
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Nod2 (nucleotide-binding oligomerization domain containing 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: activation of immune response, adaptive immune response, antibacterial innate immune response, autophagy, canonical NF-kappaB signal transduction, cellular ...
Does Knockout of Dspp in Melanoma Cell Line causally result in cell proliferation?
1
1,157
Knockout
Dspp
cell proliferation
Melanoma Cell Line
Gene: Dspp (dentin sialophosphoprotein) Type: protein-coding Summary: This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins...
Does Knockout of Atp6v1e1 in Melanoma Cell Line causally result in cell proliferation?
1
1,270
Knockout
Atp6v1e1
cell proliferation
Melanoma Cell Line
Gene: Atp6v1e1 (ATPase, H+ transporting, lysosomal V1 subunit E1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: ATPase binding, protein binding, proton-transporting ATPas...
Does Knockout of Tktl1 in Regulatory T cell causally result in protein/peptide accumulation?
0
1,482
Knockout
Tktl1
protein/peptide accumulation
Regulatory T cell
Gene: Tktl1 (transketolase-like 1) Type: protein-coding Summary: No summary available. Gene Ontology: MF: metal ion binding, thiamine pyrophosphate binding, transferase activity, transketolase activity; CC: cytoplasm, cytosol Pathways: (deoxy)ribose phosphate degradation, Pentose phosp...
Does Knockout of Chmp4b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
1
1,265
Knockout
Chmp4b
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Chmp4b (charged multivesicular body protein 4B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: autophagosome maturation, autophagy, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, m...
Does Knockout of Tnfaip1 in Melanoma Cell Line causally result in cell proliferation?
0
1,270
Knockout
Tnfaip1
cell proliferation
Melanoma Cell Line
Gene: Tnfaip1 (tumor necrosis factor, alpha-induced protein 1 (endothelial)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell migration, immune response, negative regulation of Rho protein signal transduction, positive regulation of DNA replication, proteasome-mediate...
Does Knockout of Bcl9 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
81
Knockout
Bcl9
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Bcl9 (B cell CLL/lymphoma 9) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Wnt signaling pathway, canonical Wnt signaling pathway, myoblast differentiation, myotube differentiation involved in skeletal muscle regeneration, positive regulation of transcription by R...
Does Knockout of Epas1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
Epas1
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Epas1 (endothelial PAS domain protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: angiogenesis, blood vessel remodeling, cell differentiation, cellular response to hypoxia, embryonic placenta development, epithelial cell maturation, erythrocyte differentiatio...
Does Knockout of Srpk1 in Colonic Cancer Cell Line causally result in cell proliferation?
1
1,264
Knockout
Srpk1
cell proliferation
Colonic Cancer Cell Line
Gene: Srpk1 (serine/arginine-rich protein specific kinase 1) Type: protein-coding Summary: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction; protein phosphorylation; and regulation of mRNA processing...
Does Knockout of Hip1r in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,287
Knockout
Hip1r
cell proliferation
Mouse kidney carcinoma cell
Gene: Hip1r (huntingtin interacting protein 1 related) Type: protein-coding Summary: No summary available. Gene Ontology: BP: actin filament organization, clathrin coat assembly, digestive system development, endocytosis, intrinsic apoptotic signaling pathway, membrane organization, negative re...
Does Knockout of Ocln in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,264
Knockout
Ocln
cell proliferation
Colonic Cancer Cell Line
Gene: Ocln (occludin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: bicellular tight junction assembly, cell-cell junction organization, negative regulation of gene expression, positive regulation of D-glucose import, positive regulation of blood-brain barrier permeabil...
Does Knockout of Rbm11 in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
Rbm11
cell viability
Immortal mouse chromaffin cells
Gene: Rbm11 (RNA binding motif protein 11) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA splicing, cell differentiation, cellular response to oxidative stress, mRNA processing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, nucleic acid b...
Does Knockout of Pcnt in myoblast cell line causally result in protein/peptide distribution?
1
1,679
Knockout
Pcnt
protein/peptide distribution
myoblast cell line
Gene: Pcnt (pericentrin (kendrin)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: brain morphogenesis, camera-type eye development, cerebellar cortex morphogenesis, cilium assembly, embryonic brain development, embryonic heart tube development, head development, in utero...
Does Knockout of Tmem132c in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Tmem132c
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Tmem132c (transmembrane protein 132C) Type: protein-coding Summary: No summary available. Gene Ontology: BP: biological_process, negative regulation of phosphatase activity Pathways: UniProt: Q8CEF9 Entrez ID: 208213
Does Knockout of Qser1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,267
Knockout
Qser1
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Qser1 (glutamine and serine rich 1) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cellular_component, chromosome Pathways: UniProt: A0A338P6K9 Entrez ID: 99003
Does Knockout of Ttyh2 in Embryonic Stem Cell Line causally result in cell proliferation?
0
2,477
Knockout
Ttyh2
cell proliferation
Embryonic Stem Cell Line
Gene: Ttyh2 (tweety family member 2) Type: protein-coding Summary: Enables calcium ion binding activity and volume-sensitive chloride channel activity. Involved in L-glutamate transmembrane transport. Located in plasma membrane. Is expressed in several structures, including adrenal gland; central nervou...
Does Knockout of Kdelr1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
81
Knockout
Kdelr1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Kdelr1 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: T cell apoptotic process, T cell differentiation, protein retention in ER lumen, protein transport, retrograde vesicle-mediated transpo...
Does Knockout of Evpl in myoblast cell line causally result in protein/peptide distribution?
1
1,679
Knockout
Evpl
protein/peptide distribution
myoblast cell line
Gene: Evpl (envoplakin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: intermediate filament cytoskeleton organization, keratinization, keratinocyte differentiation, regulation of antibacterial peptide production, wound healing; CC: anchoring junction, cornified envelope...
Does Knockout of Retnlg in myoblast cell line causally result in protein/peptide distribution?
1
1,679
Knockout
Retnlg
protein/peptide distribution
myoblast cell line
Gene: Retnlg (resistin like gamma) Type: protein-coding Summary: No summary available. Gene Ontology: BP: myeloid dendritic cell chemotaxis, signal transduction; CC: extracellular region, extracellular space Pathways: UniProt: Q8K426 Entrez ID: 245195
Does Knockout of Zfp397 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
2,403
Knockout
Zfp397
protein/peptide accumulation
Embryonic Cell Line
Gene: Zfp397 (zinc finger protein 397) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-speci...
Does Knockout of Nt5c3 in Embryonic Fibroblast Cell Line causally result in autophagy?
1
1,044
Knockout
Nt5c3
autophagy
Embryonic Fibroblast Cell Line
Gene: Nt5c3 (5'-nucleotidase, cytosolic III) Type: protein-coding Summary: No summary available. Gene Ontology: BP: CMP catabolic process, UMP catabolic process, adenosine metabolic process, dCMP catabolic process, dTMP catabolic process, dUMP catabolic process, defense response to virus, nucle...
Does Knockout of Ckap5 in Melanoma Cell Line causally result in cell proliferation?
1
1,270
Knockout
Ckap5
cell proliferation
Melanoma Cell Line
Gene: Ckap5 (cytoskeleton associated protein 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA transport, cell division, central nervous system myelin formation, centrosome cycle, centrosome duplication, cytoplasmic translation, dendritic spine maintenance, establish...
Does Knockout of Erbin in breast epithelium causally result in cell cycle progression?
0
1,470
Knockout
Erbin
cell cycle progression
breast epithelium
Gene: Erbin (Erbb2 interacting protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular response to tumor necrosis factor, intracellular signal transduction, negative regulation of monocyte chemotactic protein-1 production, negative regulation of nucleotide-bindi...
Does Knockout of Flad1 in Mouse kidney carcinoma cell causally result in cell proliferation?
1
1,289
Knockout
Flad1
cell proliferation
Mouse kidney carcinoma cell
Gene: Flad1 (flavin adenine dinucleotide synthetase 1) Type: protein-coding Summary: Enables FMN adenylyltransferase activity. Involved in flavin adenine dinucleotide biosynthetic process and riboflavin metabolic process. Is active in cytosol. Orthologous to human FLAD1 (flavin adenine dinucleotide synt...
Does Knockout of Nuak1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
82
Knockout
Nuak1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Nuak1 (NUAK family, SNF1-like kinase, 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, cell adhesion, protein phosphorylation, regulation of cell adhesion, regulation of cellular senescence; MF: ATP binding, kinase activity, nucleotide binding...
Does Knockout of Lyl1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,262
Knockout
Lyl1
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Lyl1 (lymphoblastomic leukemia 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: B cell differentiation, blood vessel maturation, definitive hemopoiesis, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of tr...
Does Knockout of Scgb2b2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
1
684
Knockout
Scgb2b2
cell proliferation
Acute Myeloid Leukemia Cell Line
Gene: Scgb2b2 (secretoglobin, family 2B, member 2) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cellular_component, extracellular region, extracellular space Pathways: UniProt: A0A0U1RPN9, G5E8B4 Entrez ID: 381970
Does Knockout of Fanci in Lymphoma Cell Line causally result in response to chemicals?
1
1,525
Knockout
Fanci
response to chemicals
Lymphoma Cell Line
Gene: Fanci (Fanconi anemia, complementation group I) Type: protein-coding Summary: Predicted to enable DNA polymerase binding activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within positive regulation of protein ubiquitination. Predicted to be located in cytosol and nu...
Does Knockout of Hpse2 in myoblast cell line causally result in protein/peptide distribution?
0
1,684
Knockout
Hpse2
protein/peptide distribution
myoblast cell line
Gene: Hpse2 (heparanase 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: extracellular matrix organization, positive regulation of cell population proliferation; MF: heparan sulfate proteoglycan binding, hydrolase activity, acting on glycosyl bonds; CC: extracellular ma...
Does Knockout of Fam193b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Fam193b
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Fam193b (family with sequence similarity 193, member B) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cytoplasm, nuclear speck, nucleolus, nucleoplasm, nucleus Pathways: UniProt: Q3U2K0 Entrez ID: 212483
Does Knockout of Tssk4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Tssk4
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Tssk4 (testis-specific serine kinase 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, fertilization, flagellated sperm motility, peptidyl-serine phosphorylation, peptidyl-threonine autophosphorylation, positive regulation of CREB transcriptio...
Does Knockout of Fyn in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,262
Knockout
Fyn
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Fyn (Fyn proto-oncogene) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled glutamate receptor signaling pathway, T cell receptor signaling pathway, activated T cell proliferation, adaptive immune response, cell differentiation, cell surface receptor ...
Does Knockout of Lrif1 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,264
Knockout
Lrif1
cell proliferation
Colonic Cancer Cell Line
Gene: Lrif1 (ligand dependent nuclear receptor interacting factor 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: dosage compensation by inactivation of X chromosome, regulation of DNA-templated transcription; MF: nuclear retinoic acid receptor binding, protein binding...
Does Knockout of Atp6v1b1 in myoblast cell line causally result in protein/peptide distribution?
0
1,684
Knockout
Atp6v1b1
protein/peptide distribution
myoblast cell line
Gene: Atp6v1b1 (ATPase, H+ transporting, lysosomal V1 subunit B1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ATP metabolic process, adult behavior, calcium ion homeostasis, chloride ion homeostasis, inner ear morphogenesis, monoatomic ion transport, olfactory behavio...
Does Knockout of Gm4491 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,262
Knockout
Gm4491
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Gm4491 (predicted gene 4491) Type: Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID:
Does Knockout of Ctbs in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,271
Knockout
Ctbs
cell proliferation
Mouse kidney carcinoma cell
Gene: Ctbs (chitobiase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: carbohydrate metabolic process, chitin catabolic process, oligosaccharide catabolic process; MF: chitin binding, chitinase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, h...
Does Knockout of Mir669c in Pancreatic Cancer Cell Line causally result in response to chemicals?
0
2,359
Knockout
Mir669c
response to chemicals
Pancreatic Cancer Cell Line
Gene: Mir669c (microRNA 669c) Type: ncRNA Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase...
Does Knockout of Supt3 in Embryonic Stem Cell Line causally result in cell proliferation?
1
2,477
Knockout
Supt3
cell proliferation
Embryonic Stem Cell Line
Gene: Supt3 (SPT3, SAGA and STAGA complex component) Type: protein-coding Summary: No summary available. Gene Ontology: BP: positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: protein heterodimerization ac...
Does Knockout of Sptlc1 in Embryonic Cell Line causally result in protein/peptide accumulation?
1
1,440
Knockout
Sptlc1
protein/peptide accumulation
Embryonic Cell Line
Gene: Sptlc1 (serine palmitoyltransferase, long chain base subunit 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ceramide biosynthetic process, lipid metabolic process, positive regulation of lipophagy, regulation of fat cell apoptotic process, sphinganine biosynthet...
Does Knockout of Arpc4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
83
Knockout
Arpc4
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Arpc4 (actin related protein 2/3 complex, subunit 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin filament polymerization; MF: actin binding, actin filament binding, enzyme binding, protein-macromolecule adaptor act...
Does Knockout of Isca2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Isca2
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Isca2 (iron-sulfur cluster assembly 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: iron-sulfur cluster assembly, protein maturation; MF: 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, identical protein binding, iron ion binding, iron-sulfur ...
Does Knockout of Pak1ip1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
1
2,307
Knockout
Pak1ip1
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Pak1ip1 (PAK1 interacting protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell population proliferation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of signal transduction, regulation of si...
Does Knockout of Rbm5 in Regulatory T cell causally result in protein/peptide accumulation?
0
1,482
Knockout
Rbm5
protein/peptide accumulation
Regulatory T cell
Gene: Rbm5 (RNA binding motif protein 5) Type: protein-coding Summary: Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of apoptotic process; regulation of alternative mRNA splicing, via spliceosome; and spliceosomal complex assembly. Predicted to be located in ...
Does Knockout of E2f2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
83
Knockout
E2f2
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: E2f2 (E2F transcription factor 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: intrinsic apoptotic signaling pathway by p53 class mediator, lens fiber cell apoptotic process, negative regulation of sprouting angiogenesis, positive regulation of transcription by R...