prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Prrc2a in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Prrc2a
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Prrc2a (proline-rich coiled-coil 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q7TSC1
Entrez ID: 53761
|
Does Knockout of Ackr1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ackr1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ackr1 (atypical chemokine receptor 1 (Duffy blood group))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, chemokine-mediated signaling pathway, inflammatory response, regulation of chemokine production, signal transduction; MF: C-C chemokine binding, G protein-coupled receptor activity, chemokine binding; CC: early endosome, endosome, membrane, recycling endosome
Pathways: Malaria - Mus musculus (mouse)
UniProt: Q9QUI6
Entrez ID: 13349
|
Does Knockout of Mmp17 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Mmp17
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Mmp17 (matrix metallopeptidase 17)
Type: protein-coding
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit dysfunctional vascular smooth muscle cells and altered extracellular matrix in the vessel wall leading to an increased susceptibility to angiotensin-II-induced thoracic aortic aneurysm. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: collagen catabolic process, drinking behavior, extracellular matrix organization, kidney development, proteolysis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular matrix, extracellular region, extracellular space, membrane, plasma membrane, side of membrane
Pathways: Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse)
UniProt: Q9R0S3
Entrez ID: 23948
|
Does Knockout of Dpep2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Dpep2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dpep2 (dipeptidase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: leukotriene D4 catabolic process, leukotriene metabolic process, lipid metabolic process, proteolysis; MF: dipeptidase activity, exopeptidase activity, hydrolase activity, metal ion binding, metallodipeptidase activity, metallopeptidase activity, peptidase activity; CC: membrane, plasma membrane, side of membrane
Pathways: Aflatoxin activation and detoxification, Arachidonate metabolism, Biological oxidations, Fatty acid metabolism, Metabolism, Metabolism of lipids, Synthesis of Leukotrienes (LT) and Eoxins (EX)
UniProt: Q8C255
Entrez ID: 319446
|
Does Knockout of Phf24 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Phf24
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Phf24 (PHD finger protein 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detection of mechanical stimulus involved in sensory perception of pain, gamma-aminobutyric acid signaling pathway, negative regulation of DNA-templated transcription, regulation of G protein-coupled receptor signaling pathway, regulation of synaptic transmission, GABAergic; MF: metal ion binding, protein binding, transcription corepressor activity, zinc ion binding; CC: cellular_component, cytoplasm, glutamatergic synapse, nucleus, synaptic vesicle membrane
Pathways:
UniProt: Q80TL4
Entrez ID: 230085
|
Does Knockout of Rbm44 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Rbm44
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rbm44 (RNA binding motif protein 44)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, mRNA 3'-UTR binding, nucleic acid binding, protein binding, protein homodimerization activity; CC: catalytic step 2 spliceosome, cytoplasm, intercellular bridge
Pathways:
UniProt: Q3V089
Entrez ID: 329207
|
Does Knockout of Moxd1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Moxd1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Moxd1 (monooxygenase, DBH-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dopamine catabolic process, norepinephrine biosynthetic process, octopamine biosynthetic process; MF: catalytic activity, copper ion binding, dopamine beta-monooxygenase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen; CC: endoplasmic reticulum, endoplasmic reticulum membrane, extracellular space, membrane, secretory granule membrane
Pathways: catecholamine biosynthesis
UniProt: Q9CXI3
Entrez ID: 59012
|
Does Knockout of D630033O11Rik in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
D630033O11Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: D630033O11Rik (RIKEN cDNA D630033O11 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Cenpt in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Cenpt
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cenpt (centromere protein T)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, chromosome organization, chromosome segregation, kinetochore assembly, mitotic cell cycle; MF: DNA binding, protein heterodimerization activity; CC: chromosome, chromosome, centromeric region, inner kinetochore, kinetochore, nuclear body, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q3TJM4
Entrez ID: 320394
|
Does Knockout of Abl1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Abl1
|
phagocytosis
|
macrophage
|
Gene: Abl1 (c-abl oncogene 1, non-receptor tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell proliferation, B cell proliferation involved in immune response, B cell receptor signaling pathway, B-1 B cell homeostasis, Bergmann glial cell differentiation, DN4 thymocyte differentiation, DNA conformation change, DNA damage response, DNA repair, T cell receptor signaling pathway, actin cytoskeleton organization, actin filament polymerization, activated T cell proliferation, alpha-beta T cell differentiation, apoptotic process, associative learning, autophagy, canonical NF-kappaB signal transduction, cardiac muscle cell proliferation, cell adhesion, cell-cell adhesion, cellular response to hydrogen peroxide, cellular response to lipopolysaccharide, cellular response to oxidative stress, cellular response to oxygen-containing compound, cellular response to stress, cellular response to transforming growth factor beta stimulus, cerebellum morphogenesis, circulatory system development, endocytosis, endothelial cell migration, ephrin receptor signaling pathway, epidermal growth factor receptor signaling pathway, establishment of localization in cell, immune effector process, immune response-activating cell surface receptor signaling pathway, integrin-mediated signaling pathway, intracellular signal transduction, learning or memory, microspike assembly, myoblast proliferation, negative regulation of BMP signaling pathway, negative regulation of ERK1 and ERK2 cascade, negative regulation of cell-cell adhesion, negative regulation of cellular senescence, negative regulation of double-strand break repair via homologous recombination, negative regulation of endothelial cell apoptotic process, negative regulation of intracellular signal transduction, negative regulation of long-term synaptic potentiation, negative regulation of mitotic cell cycle, neural tube closure, neuroepithelial cell differentiation, neuromuscular process controlling balance, neuron differentiation, neuropilin signaling pathway, peptidyl-tyrosine phosphorylation, phagocytosis, phospholipase C-inhibiting G protein-coupled receptor signaling pathway, plasma membrane bounded cell projection assembly, platelet-derived growth factor receptor signaling pathway, platelet-derived growth factor receptor-beta signaling pathway, podocyte apoptotic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of T cell migration, positive regulation of Wnt signaling pathway, planar cell polarity pathway, positive regulation of apoptotic process, positive regulation of blood vessel branching, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cytosolic calcium ion concentration, positive regulation of dendrite development, positive regulation of endothelial cell migration, positive regulation of establishment of T cell polarity, positive regulation of extracellular matrix organization, positive regulation of fibroblast proliferation, positive regulation of focal adhesion assembly, positive regulation of interleukin-2 production, positive regulation of mitotic cell cycle, positive regulation of neuron apoptotic process, positive regulation of osteoblast proliferation, positive regulation of phospholipase C/protein kinase C signal transduction, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of stress fiber assembly, positive regulation of substrate adhesion-dependent cell spreading, positive regulation of type II interferon production, positive regulation of vasoconstriction, post-embryonic development, protein localization to cytoplasmic microtubule plus-end, protein phosphorylation, regulation of Cdc42 protein signal transduction, regulation of T cell differentiation, regulation of actin cytoskeleton organization, regulation of axon extension, regulation of biological quality, regulation of cell cycle, regulation of cell differentiation, regulation of cell population proliferation, regulation of cellular senescence, regulation of extracellular matrix organization, regulation of microtubule polymerization, regulation of modification of synaptic structure, regulation of postsynaptic specialization assembly, regulation of transport, response to endoplasmic reticulum stress, response to epinephrine, response to oxidative stress, response to xenobiotic stimulus, signal transduction in response to DNA damage, spleen development, substrate adhesion-dependent cell spreading, thymus development, transitional one stage B cell differentiation; MF: ATP binding, DNA binding, SH2 domain binding, actin binding, actin filament binding, bubble DNA binding, delta-catenin binding, enzyme activator activity, enzyme binding, ephrin receptor binding, four-way junction DNA binding, kinase activity, magnesium ion binding, manganese ion binding, metal ion binding, mitogen-activated protein kinase binding, neuropilin binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, phosphotyrosine residue binding, proline-rich region binding, protein binding, protein domain specific binding, protein kinase C binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, sequence-specific double-stranded DNA binding, syntaxin binding, transferase activity; CC: actin cytoskeleton, cell leading edge, cytoplasm, cytoskeleton, cytosol, dendrite, glutamatergic synapse, growth cone, mitochondrion, neuron projection, neuronal cell body, nuclear body, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, protein-containing complex, ruffle
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Cyclin D associated events in G1, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Developmental Biology, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, ErbB signaling pathway - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, G1 Phase, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Immune System, Innate Immune System, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, MicroRNAs in cancer - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Myogenesis, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Ras signaling pathway - Mus musculus (mouse), Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of actin dynamics for phagocytic cup formation, Response of endothelial cells to shear stress, Role of ABL in ROBO-SLIT signaling, Signal Transduction, Signaling by ROBO receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by RUNX1, Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Viral myocarditis - Mus musculus (mouse)
UniProt: P00520
Entrez ID: 11350
|
Does Knockout of Ubr3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Ubr3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ubr3 (ubiquitin protein ligase E3 component n-recognin 3)
Type: protein-coding
Summary: Enables ubiquitin protein ligase activity. Involved in several processes, including sensory perception of smell; suckling behavior; and ubiquitin-dependent protein catabolic process. Acts upstream of or within in utero embryonic development and olfactory behavior. Predicted to be located in membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in cranial ganglion and dorsal root ganglion. Orthologous to human UBR3 (ubiquitin protein ligase E3 component n-recognin 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: embryo development ending in birth or egg hatching, in utero embryonic development, negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, olfactory behavior, positive regulation of protein catabolic process, protein ubiquitination, proteolysis involved in protein catabolic process, sensory perception of smell, suckling behavior, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the N-end rule pathway; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, membrane, ubiquitin ligase complex
Pathways:
UniProt: Q5U430
Entrez ID: 68795
|
Does Activation of Arl2 in Mouse cell causally result in protein/peptide accumulation?
| 1
| 690
|
Activation
|
Arl2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Arl2 (ADP-ribosylation factor-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine transport, bicellular tight junction assembly, centrosome cycle, maintenance of protein location in nucleus, negative regulation of GTPase activity, positive regulation of cell-substrate adhesion, positive regulation of microtubule polymerization, protein folding, regulation of aerobic respiration, regulation of glycolytic process, regulation of microtubule polymerization; MF: GDP binding, GTP binding, GTPase activity, nucleotide binding, protein binding; CC: centrosome, ciliary basal body, cytoplasm, cytoskeleton, lateral plasma membrane, microtubule cytoskeleton, mitochondrial intermembrane space, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, RAS processing, SLC-mediated transmembrane transport, Signal Transduction, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q9D0J4
Entrez ID: 56327
|
Does Knockout of Lrrc17 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Lrrc17
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lrrc17 (leucine rich repeat containing 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone marrow development, negative regulation of osteoclast differentiation, ossification, osteoblast differentiation, osteoblast proliferation; MF: molecular_function, signaling receptor activity; CC: extracellular region, extracellular space, plasma membrane
Pathways:
UniProt: Q9CXD9
Entrez ID: 74511
|
Does Knockout of Plch2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Plch2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Plch2 (phospholipase C, eta 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, lipid catabolic process, lipid metabolic process, phosphatidylinositol metabolic process, phosphatidylinositol-mediated signaling, phospholipase C-activating G protein-coupled receptor signaling pathway, release of sequestered calcium ion into cytosol, signal transduction; MF: calcium ion binding, hydrolase activity, metal ion binding, phosphatidylinositol-4,5-bisphosphate phospholipase C activity, phospholipase C activity, phosphoric diester hydrolase activity; CC: cytoplasm, membrane, plasma membrane
Pathways: D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, D-<i>myo</i>-inositol-5-phosphate metabolism, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, PIP metabolism, Synthesis of IP3 and IP4 in the cytosol, phospholipases
UniProt: A2AP18
Entrez ID: 269615
|
Does Knockout of Reg3d in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Reg3d
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Reg3d (regenerating islet-derived 3 delta)
Type: protein-coding
Summary: Predicted to enable oligosaccharide binding activity; peptidoglycan binding activity; and signaling receptor activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide; positive regulation of cell population proliferation; and response to peptide hormone. Predicted to be active in extracellular space. Orthologous to human REG3A (regenerating family member 3 alpha) and REG3G (regenerating family member 3 gamma). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, positive regulation of cell population proliferation, response to peptide hormone; MF: carbohydrate binding, hormone activity, identical protein binding, oligosaccharide binding, peptidoglycan binding, signaling receptor activity; CC: extracellular region, extracellular space
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: Q9QUS9, G3UWG6
Entrez ID: 30053
|
Does Knockout of Rab33b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Rab33b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rab33b (RAB33B, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rab protein signal transduction, autophagosome assembly, autophagy, intra-Golgi vesicle-mediated transport, negative regulation of constitutive secretory pathway, protein localization to Golgi apparatus, protein localization to phagophore assembly site, protein transport, regulation of Golgi organization, regulation of exocytosis, regulation of retrograde vesicle-mediated transport, Golgi to ER, skeletal system morphogenesis; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi lumen, Golgi membrane, endosome, membrane, phagophore assembly site membrane, presynapse
Pathways: Autophagy - animal - Mus musculus (mouse), Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB geranylgeranylation, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: O35963
Entrez ID: 19338
|
Does Knockout of Miga1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Miga1
|
cell cycle progression
|
breast epithelium
|
Gene: Miga1 (mitoguardin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial fusion; MF: protein heterodimerization activity, protein homodimerization activity; CC: membrane, mitochondrial outer membrane, mitochondrion, plasma membrane
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA
UniProt: Q4QQM5
Entrez ID: 215708
|
Does Knockout of Tsfm in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Tsfm
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tsfm (Ts translation elongation factor, mitochondrial)
Type: protein-coding
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation and regulation of mitochondrial translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 3. Orthologous to human TSFM (Ts translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: mitochondrial translational elongation, translation, translational elongation; MF: translation elongation factor activity; CC: intracellular organelle lumen, mitochondrion, nucleoplasm
Pathways:
UniProt: Q9CZR8
Entrez ID: 66399
|
Does Knockout of Exosc3 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Exosc3
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Exosc3 (exosome component 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CUT catabolic process, DNA deamination, DNA metabolic process, RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, U4 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), gene expression, isotype switching, mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear-transcribed mRNA catabolic process, poly(A)-dependent snoRNA 3'-end processing, positive regulation of isotype switching, rRNA processing, regulation of gene expression; MF: RNA binding, exonuclease activity, hydrolase activity, nuclease activity; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, euchromatin, exosome (RNase complex), nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q7TQK4
Entrez ID: 66362
|
Does Knockout of Usp51 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Usp51
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Usp51 (ubiquitin specific protease 51)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, protein deubiquitination, proteolysis, regulation of cell cycle process, regulation of double-strand break repair via homologous recombination, regulation of double-strand break repair via nonhomologous end joining; MF: chromatin binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2A deubiquitinase activity, histone binding, hydrolase activity, metal ion binding, peptidase activity, zinc ion binding
Pathways:
UniProt: B1AY15
Entrez ID: 635253
|
Does Knockout of Snrnp70 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Snrnp70
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Snrnp70 (small nuclear ribonucleoprotein 70 (U1))
Type: protein-coding
Summary: This gene encodes a subunit of the U1 snRNP (small nuclear ribonucleic particle), one of at least five snRNPs to comprise the spliceosome, which functions in processing of pre-mRNAs. The U1 snRNP has been shown to be important in defining the 5' splice site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, mRNA splicing, via spliceosome, negative regulation of chaperone-mediated autophagy, negative regulation of protein refolding, positive regulation of mRNA splicing, via spliceosome, regulation of RNA splicing; MF: RNA binding, U1 snRNA binding, U1 snRNP binding, mRNA binding, nucleic acid binding; CC: U1 snRNP, U2-type prespliceosome, lysosomal lumen, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q62376
Entrez ID: 20637
|
Does Knockout of Drap1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Drap1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Drap1 (DR1 associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II general transcription initiation factor binding, TBP-class protein binding, core promoter sequence-specific DNA binding, identical protein binding, protein binding, protein heterodimerization activity, transcription corepressor activity; CC: RNA polymerase II transcription regulator complex, negative cofactor 2 complex, nucleus
Pathways:
UniProt: Q9D6N5
Entrez ID: 66556
|
Does Knockout of Mgat1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Mgat1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mgat1 (mannoside acetylglucosaminyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: UDP-N-acetylglucosamine catabolic process, in utero embryonic development, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; MF: acetylglucosaminyltransferase activity, alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity, glycosyltransferase activity, manganese ion binding, metal ion binding, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, membrane, perinuclear region of cytoplasm
Pathways: Asparagine N-linked glycosylation, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), N-glycan trimming and elongation in the cis-Golgi, Post-translational protein modification, Transport to the Golgi and subsequent modification, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: P27808
Entrez ID: 17308
|
Does Knockout of Them7 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Them7
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Them7 (thioesterase superfamily member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: fatty acyl-CoA hydrolase activity, molecular_function
Pathways:
UniProt: Q9DCP4
Entrez ID: 74088
|
Does Knockout of Med23 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Med23
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Med23 (mediator complex subunit 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of T cell extravasation, positive regulation of gene expression, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, transcription regulator complex, ubiquitin ligase complex
Pathways:
UniProt: Q80YQ2
Entrez ID: 70208
|
Does Knockout of Slc17a9 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Slc17a9
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Slc17a9 (solute carrier family 17, member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ADP transport, ATP export, ATP transport, guanine nucleotide transmembrane transport, lysosomal protein catabolic process, purine nucleotide import into lysosome, purine-containing compound transmembrane transport, transmembrane transport; MF: ADP transmembrane transporter activity, ATP transmembrane transporter activity, guanine nucleotide transmembrane transporter activity, purine nucleotide uniporter activity, transmembrane transporter activity; CC: chromaffin granule membrane, cytoplasmic vesicle, lysosomal membrane, lysosome, membrane, mucin granule, secretory granule, transport vesicle membrane
Pathways:
UniProt: Q8VCL5
Entrez ID: 228993
|
Does Knockout of Vmn1r89 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Vmn1r89
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmn1r89 (vomeronasal 1 receptor 89)
Type: protein-coding
Summary: Predicted to enable pheromone binding activity and pheromone receptor activity. Predicted to act upstream of or within response to pheromone. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BQD8, Q8R256, A0A2I3BRH8, A0A2I3BQ60
Entrez ID: 171260
|
Does Knockout of Fam217b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Fam217b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fam217b (family with sequence similarity 217, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytosol, nucleoplasm
Pathways:
UniProt: A2AJW5
Entrez ID: 71532
|
Does Knockout of Ncoa6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Ncoa6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ncoa6 (nuclear receptor coactivator 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA-templated transcription initiation, brain development, chromatin organization, heart development, labyrinthine layer blood vessel development, myeloid cell differentiation, positive regulation of DNA-templated transcription, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of peptide secretion, positive regulation of transcription by RNA polymerase II, regulation of gene expression; MF: chromatin binding, chromatin-protein adaptor activity, enzyme binding, histone methyltransferase binding, identical protein binding, nuclear estrogen receptor binding, nuclear glucocorticoid receptor binding, nuclear retinoic acid receptor binding, nuclear retinoid X receptor binding, nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, peroxisome proliferator activated receptor binding, protein domain specific binding, transcription coactivator activity; CC: MLL3/4 complex, cytosol, histone methyltransferase complex, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways:
UniProt: F6M2J9, Q5XJV5, A2AQN0, A2AQM9
Entrez ID: 56406
|
Does Knockout of Mrps15 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Mrps15
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mrps15 (mitochondrial ribosomal protein S15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrial small ribosomal subunit, mitochondrion, nucleolus, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9DC71
Entrez ID: 66407
|
Does Knockout of Dynlrb1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Dynlrb1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Dynlrb1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule-based movement, visual behavior; MF: dynein intermediate chain binding, identical protein binding, protein binding; CC: centrosome, cytoplasm, cytoplasmic dynein complex, cytoskeleton, dynein complex, microtubule
Pathways: Cilium Assembly, Intraflagellar transport, Organelle biogenesis and maintenance, Salmonella infection - Mus musculus (mouse)
UniProt: P62627
Entrez ID: 67068
|
Does Knockout of Zmym6 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Zmym6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zmym6 (zinc finger, MYM-type 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoskeleton organization, regulation of cell morphogenesis
Pathways:
UniProt: A2A7U2, Q8BS54
Entrez ID: 100177
|
Does Knockout of Zc3h4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Zc3h4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Zc3h4 (zinc finger CCCH-type containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription termination, lncRNA catabolic process, negative regulation of DNA-templated transcription, negative regulation of DNA-templated transcription, elongation, negative regulation of lncRNA transcription, nuclear RNA surveillance; MF: RNA binding, chromatin binding, metal ion binding, promoter-specific chromatin binding, protein binding, zinc ion binding; CC: chromosome, cytosol, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Nuclear RNA decay
UniProt: Q6ZPZ3
Entrez ID: 330474
|
Does Knockout of Pon2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Pon2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pon2 (paraoxonase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lactone catabolic process, response to toxic substance; MF: acyl-L-homoserine-lactone lactonohydrolase activity, arylesterase activity, hydrolase activity, metal ion binding, protein homodimerization activity; CC: extracellular region, membrane, plasma membrane
Pathways: Arachidonate metabolism, Fatty acid metabolism, Metabolism, Metabolism of lipids, Synthesis of 5-eicosatetraenoic acids, parathion degradation
UniProt: Q62086
Entrez ID: 330260
|
Does Knockout of Nipsnap3b in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Nipsnap3b
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nipsnap3b (nipsnap homolog 3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, mitophagy; CC: cytoplasm, cytosol, mitochondrion
Pathways:
UniProt: Q9CQE1
Entrez ID: 66536
|
Does Knockout of Zfp750 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Zfp750
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp750 (zinc finger protein 750)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, epidermis development, establishment of skin barrier, membrane biogenesis, negative regulation of epithelial to mesenchymal transition, negative regulation of transcription by RNA polymerase II, positive regulation of ceramide biosynthetic process, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, promoter-specific chromatin binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q8BH05
Entrez ID: 319530
|
Does Knockout of Itk in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Itk
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Itk (IL2 inducible T cell kinase)
Type: protein-coding
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including T cell receptor signaling pathway; gamma-delta T cell activation; and protein phosphorylation. Acts upstream of or within NK T cell differentiation. Located in cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell receptor signaling pathway, NK T cell differentiation, T cell activation, T cell receptor signaling pathway, adaptive immune response, gamma-delta T cell activation, immune system process, intracellular signal transduction, positive regulation of cytokine production, protein phosphorylation, signal transduction; MF: ATP binding, kinase activity, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, zinc ion binding; CC: cell-cell junction, cytoplasm, cytosol, nucleus, plasma membrane
Pathways: Adaptive Immune System, Chemokine signaling pathway - Mus musculus (mouse), FCERI mediated Ca+2 mobilization, Fc epsilon receptor (FCERI) signaling, Generation of second messenger molecules, Immune System, Innate Immune System, Leukocyte transendothelial migration - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling
UniProt: Q03526
Entrez ID: 16428
|
Does Knockout of Snrnp70 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Snrnp70
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Snrnp70 (small nuclear ribonucleoprotein 70 (U1))
Type: protein-coding
Summary: This gene encodes a subunit of the U1 snRNP (small nuclear ribonucleic particle), one of at least five snRNPs to comprise the spliceosome, which functions in processing of pre-mRNAs. The U1 snRNP has been shown to be important in defining the 5' splice site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, mRNA splicing, via spliceosome, negative regulation of chaperone-mediated autophagy, negative regulation of protein refolding, positive regulation of mRNA splicing, via spliceosome, regulation of RNA splicing; MF: RNA binding, U1 snRNA binding, U1 snRNP binding, mRNA binding, nucleic acid binding; CC: U1 snRNP, U2-type prespliceosome, lysosomal lumen, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q62376
Entrez ID: 20637
|
Does Knockout of Polh in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,523
|
Knockout
|
Polh
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Polh (polymerase (DNA directed), eta (RAD 30 related))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA synthesis involved in DNA repair, cellular response to UV-C, error-prone translesion synthesis, postreplication repair, pyrimidine dimer repair, response to UV-C, response to radiation; MF: DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, damaged DNA binding, metal ion binding, nucleotidyltransferase activity, transferase activity, zinc ion binding; CC: cytosol, nucleoplasm, nucleus, replication fork, site of double-strand break
Pathways: DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Termination of translesion DNA synthesis, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9JJN0
Entrez ID: 80905
|
Does Knockout of Aamp in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Aamp
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Aamp (angio-associated migratory protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cell surface, cytoplasm, intercellular bridge, microtubule cytoskeleton, plasma membrane
Pathways: Hemostasis, Immune System, Innate Immune System, NOD1/2 Signaling Pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Platelet activation, signaling and aggregation, Signal Transduction, Signal amplification, Signaling by EGFR, Signaling by Receptor Tyrosine Kinases, Thromboxane signalling through TP receptor
UniProt: J3QN89, Q3TJ22, A0A087WR11, A0A087WNM5
Entrez ID: 227290
|
Does Knockout of Malt1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Malt1
|
phagocytosis
|
macrophage
|
Gene: Malt1 (MALT1 paracaspase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B-1 B cell differentiation, T cell proliferation, T cell receptor signaling pathway, apoptotic process, canonical NF-kappaB signal transduction, cell development, cellular response to lipopolysaccharide, immune system process, innate immune response, lipopolysaccharide-mediated signaling pathway, nuclear export, positive regulation of T cell activation, positive regulation of T cell cytokine production, positive regulation of T-helper 17 cell differentiation, positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, positive regulation of canonical NF-kappaB signal transduction, positive regulation of immune effector process, positive regulation of interleukin-1 beta production, positive regulation of interleukin-2 production, positive regulation of multicellular organismal process, proteolysis, proteolysis involved in protein catabolic process, regulation of T cell receptor signaling pathway, regulation of apoptotic process, regulation of signal transduction, response to fungus; MF: cysteine-type endopeptidase activity, endopeptidase activator activity, endopeptidase activity, hydrolase activity, identical protein binding, kinase activator activity, peptidase activity, protease binding, protein binding, small molecule binding, ubiquitin-protein transferase activity; CC: CBM complex, cytoplasm, cytosol, fibrillar center, nucleus, perinuclear region of cytoplasm, polkadots, protein-containing complex
Pathways: B cell receptor signaling pathway - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q2TBA3
Entrez ID: 240354
|
Does Knockout of Mapkapk2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Mapkapk2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mapkapk2 (MAP kinase-activated protein kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, DNA damage response, MAPK cascade, cellular response to vascular endothelial growth factor stimulus, inflammatory response, inner ear development, intracellular signal transduction, mRNA stabilization, macropinocytosis, p38MAPK cascade, positive regulation of macrophage cytokine production, positive regulation of tumor necrosis factor production, protein phosphorylation, regulation of interleukin-6 production, regulation of tumor necrosis factor production, response to cytokine, response to lipopolysaccharide, toll-like receptor signaling pathway, vascular endothelial growth factor receptor signaling pathway; MF: ATP binding, calcium-dependent protein serine/threonine kinase activity, calcium/calmodulin-dependent protein kinase activity, calmodulin binding, kinase activity, mitogen-activated protein kinase binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, ciliary basal body, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Arachidonate metabolism, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, C-type lectin receptor signaling pathway - Mus musculus (mouse), CREB phosphorylation, Cellular Senescence, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Cytokine Signaling in Immune system, Death Receptor Signaling, Fatty acid metabolism, Immune System, Innate Immune System, Interleukin-17 signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), MAPK targets/ Nuclear events mediated by MAP kinases, Metabolism, Metabolism of RNA, Metabolism of lipids, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Neurotrophin signaling pathway - Mus musculus (mouse), Nuclear Events (kinase and transcription factor activation), Oxidative Stress Induced Senescence, Regulation of HSF1-mediated heat shock response, Regulation of TNFR1 signaling, Regulation of mRNA stability by proteins that bind AU-rich elements, Signal Transduction, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Signalling to ERKs, Signalling to RAS, Synthesis of Leukotrienes (LT) and Eoxins (EX), TNF signaling, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Viral carcinogenesis - Mus musculus (mouse), activated TAK1 mediates p38 MAPK activation, p38MAPK events
UniProt: P49138
Entrez ID: 17164
|
Does Knockout of Swt1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Swt1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Swt1 (SWT1 RNA endoribonuclease homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DBQ9
Entrez ID: 66875
|
Does Knockout of Sppl2b in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Sppl2b
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Sppl2b (signal peptide peptidase like 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, membrane protein proteolysis, proteolysis, regulation of immune response; MF: aspartic endopeptidase activity, intramembrane cleaving, hydrolase activity, peptidase activity, protein homodimerization activity; CC: Golgi apparatus, Golgi membrane, Golgi-associated vesicle membrane, actin cytoskeleton, centrosome, cytoplasmic side of endoplasmic reticulum membrane, endosome, endosome membrane, lumenal side of endoplasmic reticulum membrane, lysosomal membrane, lysosome, membrane, nucleoplasm, organelle membrane, plasma membrane
Pathways: Death Receptor Signaling, Regulation of TNFR1 signaling, Signal Transduction, TNF signaling
UniProt: Q3TD49
Entrez ID: 73218
|
Does Knockout of Jun in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Jun
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Jun (jun proto-oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, JNK cascade, SMAD protein signal transduction, angiogenesis, axon regeneration, cellular response to anisomycin, cellular response to calcium ion, cellular response to hypoxia, cellular response to potassium ion starvation, cellular response to prolactin, cellular response to zinc ion starvation, circadian rhythm, eyelid development in camera-type eye, host-mediated activation of viral transcription, host-mediated suppression of viral transcription, leading edge cell differentiation, learning, liver development, membrane depolarization, microglial cell activation, monocyte differentiation, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, outflow tract morphogenesis, positive regulation of DNA replication, positive regulation of DNA-templated transcription, positive regulation of DNA-templated transcription initiation, positive regulation of ERK1 and ERK2 cascade, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, positive regulation of cell population proliferation, positive regulation of endothelial cell proliferation, positive regulation of epithelial cell migration, positive regulation of fibroblast proliferation, positive regulation of miRNA transcription, positive regulation of monocyte differentiation, positive regulation of neuron apoptotic process, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell proliferation, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell population proliferation, regulation of transcription by RNA polymerase II, release from viral latency, release of cytochrome c from mitochondria, response to cAMP, response to cytokine, response to endoplasmic reticulum stress, response to ethanol, response to forskolin, response to hydrogen peroxide, response to insulin, response to lipopolysaccharide, response to mechanical stimulus, response to muscle stretch, response to steroid hormone, response to xenobiotic stimulus, transcription by RNA polymerase II, transforming growth factor beta receptor signaling pathway; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, GTPase activator activity, HMG box domain binding, R-SMAD binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding, chromatin binding, double-stranded DNA binding, enzyme binding, general transcription initiation factor binding, identical protein binding, protein binding, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, ubiquitin protein ligase binding, ubiquitin-like protein ligase binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytosol, euchromatin, nucleoplasm, nucleus, protein-containing complex, transcription factor AP-1 complex, transcription regulator complex, transcription repressor complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Activation of the AP-1 family of transcription factors, Amphetamine addiction - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), FCERI mediated MAPK activation, Fc epsilon receptor (FCERI) signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Innate Immune System, Interleukin-17 signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), MAPK targets/ Nuclear events mediated by MAP kinases, Measles - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse), MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NOD-like receptor signaling pathway - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Oxidative Stress Induced Senescence, Oxytocin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signaling by Interleukins, T cell receptor signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: P05627
Entrez ID: 16476
|
Does Knockout of Pkm in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Pkm
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pkm (pyruvate kinase, muscle)
Type: protein-coding
Summary: Enables mRNA binding activity and pyruvate kinase activity. Involved in canonical glycolysis and positive regulation of cytoplasmic translation. Located in cilium and rough endoplasmic reticulum. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: canonical glycolysis, cellular response to insulin stimulus, chromatin remodeling, glucose metabolic process, glycolytic process, positive regulation of cytoplasmic translation, positive regulation of sprouting angiogenesis, positive regulation of transcription by RNA polymerase II, programmed cell death, regulation of translation; MF: ADP binding, ATP binding, catalytic activity, histone H3T11 kinase activity, identical protein binding, kinase activity, mRNA binding, magnesium ion binding, metal ion binding, nucleotide binding, potassium ion binding, protein binding, protein dimerization activity, protein homodimerization activity, protein tyrosine kinase activity, pyruvate kinase activity, thyroid hormone binding, transcription coactivator activity, transferase activity; CC: cilium, cytoplasm, cytosol, mitochondrion, myelin sheath, nucleus, photoreceptor inner segment, pyruvate kinase complex, rough endoplasmic reticulum
Pathways: Aerobic respiration and respiratory electron transport, Central carbon metabolism in cancer - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Purine metabolism - Mus musculus (mouse), Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), Regulation of pyruvate metabolism, Type II diabetes mellitus - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), glycolysis I, glycolysis III, glycolysis V (Pyrococcus)
UniProt: P52480
Entrez ID: 18746
|
Does Knockout of Srbd1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Srbd1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Srbd1 (S1 RNA binding domain 1)
Type: protein-coding
Summary: Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Is expressed in olfactory epithelium and thymus primordium. Orthologous to human SRBD1 (S1 RNA binding domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: nucleobase-containing compound metabolic process, translation; MF: RNA binding, mRNA binding, nucleic acid binding, structural constituent of ribosome
Pathways:
UniProt: Q8CHZ0, F8WGW3, B7ZWI4, B7ZWI7
Entrez ID: 78586
|
Does Knockout of Col7a1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Col7a1
|
phagocytosis
|
macrophage
|
Gene: Col7a1 (collagen, type VII, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, collagen fibril organization; MF: extracellular matrix structural constituent conferring tensile strength, identical protein binding, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: basement membrane, collagen trimer, extracellular matrix, extracellular region
Pathways: Anchoring fibril formation, Asparagine N-linked glycosylation, Assembly of collagen fibrils and other multimeric structures, COPII-mediated vesicle transport, Cargo concentration in the ER, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, ER to Golgi Anterograde Transport, Extracellular matrix organization, Fibronectin matrix formation, Integrin cell surface interactions, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein digestion and absorption - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q63870
Entrez ID: 12836
|
Does Knockout of Vps16 in macrophage causally result in phagocytosis?
| 1
| 1,888
|
Knockout
|
Vps16
|
phagocytosis
|
macrophage
|
Gene: Vps16 (VSP16 CORVET/HOPS core subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, endosomal transport, endosome to lysosome transport, intracellular protein transport, protein transport, symbiont entry into host cell, vacuole fusion, non-autophagic, vacuole organization; MF: actin binding, actin filament binding, protein binding; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, actin filament, autophagosome, axon, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, early endosome, early endosome membrane, endosome, endosome membrane, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, neuronal cell body, presynapse, recycling endosome, vesicle tethering complex
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: G3X8X7, Q8BWV2, Q8C016, A2BI90
Entrez ID: 80743
|
Does Knockout of Fgd1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Fgd1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fgd1 (FYVE, RhoGEF and PH domain containing 1)
Type: protein-coding
Summary: This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as molecular switches in signaling. This protein specifically binds cell division cycle 42, a Rho (Ras homology) GTPase. Investigations in mouse suggest that this protein is important for skeletal mineralization and for regulating the actin cytoskeleton. In humans, mutations in this gene are associated with faciogenital dysplasia, also known as Aarskog-Scott syndrome. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: actin cytoskeleton organization, cytoskeleton organization, filopodium assembly, regulation of cell shape; MF: guanyl-nucleotide exchange factor activity, metal ion binding, protein binding, small GTPase binding, zinc ion binding; CC: Golgi apparatus, cell leading edge, cell projection, cytoplasm, cytoskeleton, cytosol, lamellipodium, plasma membrane, ruffle
Pathways: CDC42 GTPase cycle, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, RHO GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p75 NTR receptor-mediated signalling
UniProt: P52734
Entrez ID: 14163
|
Does Knockout of Pik3c3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,288
|
Knockout
|
Pik3c3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pik3c3 (phosphatidylinositol 3-kinase catalytic subunit type 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagosome maturation, autophagy, cell division, cellular response to glucose starvation, cellular response to starvation, early endosome to late endosome transport, endocytosis, endosome organization, host-mediated activation of viral genome replication, interleukin-6-mediated signaling pathway, lipid metabolic process, macroautophagy, pexophagy, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, positive regulation of natural killer cell mediated cytotoxicity, protein localization to phagophore assembly site, protein processing, protein targeting to lysosome, regulation of autophagy, regulation of cytokinesis, regulation of macroautophagy, response to L-leucine, synaptic vesicle endocytosis, type II interferon-mediated signaling pathway; MF: 1-phosphatidylinositol-3-kinase activity, ATP binding, kinase activity, nucleotide binding, phosphatidylinositol kinase activity, phosphotransferase activity, alcohol group as acceptor, protein binding, protein kinase activity, transferase activity; CC: GABA-ergic synapse, autolysosome, autophagosome, cytoplasm, cytoplasmic vesicle, endosome, glutamatergic synapse, late endosome, membrane, midbody, peroxisome, phagocytic vesicle, phagophore assembly site, phosphatidylinositol 3-kinase complex, class III, phosphatidylinositol 3-kinase complex, class III, type I, phosphatidylinositol 3-kinase complex, class III, type II, plasma membrane, postsynapse, postsynaptic endosome, presynaptic endosome
Pathways: 3-phosphoinositide biosynthesis, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Innate Immune System, Inositol phosphate metabolism - Mus musculus (mouse), Insulin receptor signalling cascade, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Macroautophagy, Metabolism, Metabolism of lipids, PI Metabolism, PI3K Cascade, PIP metabolism, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Spinocerebellar ataxia - Mus musculus (mouse), Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Tuberculosis - Mus musculus (mouse)
UniProt: Q6PF93
Entrez ID: 225326
|
Does Knockout of Mrps35 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,525
|
Knockout
|
Mrps35
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Mrps35 (mitochondrial ribosomal protein S35)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: cytosol, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q8BJZ4
Entrez ID: 232536
|
Does Knockout of Spc25 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Spc25
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Spc25 (SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae))
Type: protein-coding
Summary: This gene encodes a component of the kinetochore-associated NDC80 protein complex, which is required for the mitotic spindle checkpoint and for microtubule-kinetochore attachment. During meiosis in mouse, the protein localizes to the germinal vesicle and then is associated with the chromosomes following germinal vesicle breakdown. Knockdown of this gene in oocytes results in precocious polar body extrusion, chromosome misalignment and aberrant spindle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization; CC: Ndc80 complex, chromosome, chromosome, centromeric region, cytosol, kinetochore, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q3UA16
Entrez ID: 66442
|
Does Knockout of Wdr6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Wdr6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Wdr6 (WD repeat domain 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1 to G0 transition, negative regulation of autophagy, negative regulation of cell population proliferation, tRNA methylation, tRNA processing, wobble position ribose methylation; MF: enzyme regulator activity, insulin receptor substrate binding, tRNA binding; CC: COP9 signalosome, cytoplasm, cytosol, plasma membrane, protein-containing complex
Pathways: RHO GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, RND1 GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q99ME2
Entrez ID: 83669
|
Does Knockout of Adam1b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Adam1b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Adam1b (a disintegrin and metallopeptidase domain 1b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, male gonad development, proteolysis, spermatogenesis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein binding; CC: external side of plasma membrane, membrane, plasma membrane, sperm head plasma membrane
Pathways:
UniProt: Q8R534
Entrez ID: 280667
|
Does Knockout of Mecr in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Mecr
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mecr (mitochondrial trans-2-enoyl-CoA reductase)
Type: protein-coding
Summary: Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity; nuclear receptor binding activity; and signaling receptor binding activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. Is expressed in submandibular gland primordium. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ceramide biosynthetic process, fatty acid biosynthetic process, fatty acid metabolic process, intracellular iron ion homeostasis, lipid metabolic process; MF: enoyl-[acyl-carrier-protein] reductase (NADPH) activity, nuclear receptor binding, oxidoreductase activity, signaling receptor binding; CC: cytosol, membrane, mitochondrion, nucleus
Pathways: Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA, Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, mitochondrial fatty acid beta-oxidation of saturated fatty acids, very long chain fatty acid biosynthesis
UniProt: Q9DCS3
Entrez ID: 26922
|
Does Knockout of Nod2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Nod2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Nod2 (nucleotide-binding oligomerization domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of immune response, adaptive immune response, antibacterial innate immune response, autophagy, canonical NF-kappaB signal transduction, cellular response to lipopolysaccharide, cellular response to muramyl dipeptide, cellular response to peptidoglycan, defense response, defense response to Gram-positive bacterium, defense response to bacterium, detection of bacterium, detection of biotic stimulus, detection of muramyl dipeptide, establishment of localization in cell, host-mediated modulation of intestinal microbiota composition, immune system process, inflammatory response, innate immune response, innate immune response in mucosa, intestinal stem cell homeostasis, intracellular signal transduction, maintenance of gastrointestinal epithelium, negative regulation of T cell mediated immunity, negative regulation of canonical NF-kappaB signal transduction, negative regulation of inflammatory response to antigenic stimulus, negative regulation of interleukin-12 production, negative regulation of interleukin-18 production, negative regulation of interleukin-2 production, negative regulation of macrophage apoptotic process, negative regulation of macrophage cytokine production, negative regulation of toll-like receptor 2 signaling pathway, negative regulation of tumor necrosis factor production, negative regulation of type II interferon production, nucleotide-binding oligomerization domain containing 2 signaling pathway, p38MAPK cascade, pattern recognition receptor signaling pathway, positive regulation of B cell activation, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of Notch signaling pathway, positive regulation of antibacterial peptide biosynthetic process, positive regulation of autophagy, positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell population proliferation, positive regulation of cytokine production involved in immune response, positive regulation of cytokine production involved in inflammatory response, positive regulation of dendritic cell antigen processing and presentation, positive regulation of dendritic cell cytokine production, positive regulation of epithelial cell proliferation, positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of innate immune response, positive regulation of interleukin-1 beta production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-17 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of macrophage cytokine production, positive regulation of mitophagy, positive regulation of monocyte chemotactic protein-1 production, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of phagocytosis, positive regulation of protein K63-linked ubiquitination, positive regulation of protein ubiquitination, positive regulation of stress-activated MAPK cascade, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type 2 immune response, positive regulation of xenophagy, protein K63-linked ubiquitination, protein linear polyubiquitination, regulation of apoptotic process, regulation of appetite, regulation of inflammatory response, regulation of neutrophil chemotaxis, response to endoplasmic reticulum stress, response to exogenous dsRNA, response to lipopolysaccharide, response to muramyl dipeptide, response to peptidoglycan, signal transduction, temperature homeostasis; MF: ADP binding, ATP binding, CARD domain binding, Hsp70 protein binding, Hsp90 protein binding, actin binding, anion binding, carbohydrate derivative binding, enzyme binding, muramyl dipeptide binding, nucleotide binding, pattern recognition receptor activity, peptidoglycan binding, protein binding, protein kinase binding, protein-containing complex binding, ubiquitin binding; CC: Golgi apparatus, basolateral plasma membrane, cell surface, cytoplasm, cytoskeleton, cytosol, extrinsic component of plasma membrane, membrane, mitochondrion, phagocytic vesicle, plasma membrane, protein-containing complex, vesicle
Pathways: Inflammatory bowel disease - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q8K3Z0
Entrez ID: 257632
|
Does Knockout of Dspp in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,157
|
Knockout
|
Dspp
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dspp (dentin sialophosphoprotein)
Type: protein-coding
Summary: This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mice lacking the encoded protein exhibit hypomineralization defects in dentin, similar to human dentinogenesis imperfecta. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: S-shaped body morphogenesis, ameloblast differentiation, amelogenesis, biomineral tissue development, branching involved in ureteric bud morphogenesis, cellular response to cell-matrix adhesion, connective tissue development, dentinogenesis, endochondral bone morphogenesis, gene expression involved in extracellular matrix organization, lung morphogenesis, mandibular condyle articular cartilage development, mesenchymal to epithelial transition, negative regulation of bone development, negative regulation of chondrocyte proliferation, negative regulation of growth plate cartilage chondrocyte proliferation, negative regulation of mesenchymal cell apoptotic process, odontoblast differentiation, odontogenesis, positive regulation of calcium ion import, positive regulation of chondrocyte proliferation, positive regulation of enamel mineralization, regulation of odontoblast differentiation; MF: collagen binding, protein binding; CC: cytoplasm, extracellular matrix, extracellular region, extracellular space, nucleus, plasma membrane
Pathways: ECM-receptor interaction - Mus musculus (mouse)
UniProt: E9Q9Z9
Entrez ID: 666279
|
Does Knockout of Atp6v1e1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Atp6v1e1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Atp6v1e1 (ATPase, H+ transporting, lysosomal V1 subunit E1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, endosome, extrinsic component of synaptic vesicle membrane, membrane, microvillus, mitochondrion, plasma membrane, proton-transporting two-sector ATPase complex, catalytic domain, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: P50518
Entrez ID: 11973
|
Does Knockout of Tktl1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Tktl1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Tktl1 (transketolase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, thiamine pyrophosphate binding, transferase activity, transketolase activity; CC: cytoplasm, cytosol
Pathways: (deoxy)ribose phosphate degradation, Pentose phosphate pathway - Mus musculus (mouse), pentose phosphate pathway, pentose phosphate pathway (non-oxidative branch)
UniProt: Q99MX0
Entrez ID: 83553
|
Does Knockout of Chmp4b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Chmp4b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Chmp4b (charged multivesicular body protein 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, membrane fission, midbody abscission, mitotic cytokinesis, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein transport, regulation of autophagy, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; MF: identical protein binding, protein binding, protein homodimerization activity; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endosome, endosome membrane, glutamatergic synapse, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, membrane coat, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleus, plasma membrane, postsynaptic density, vesicle
Pathways: Autophagy, Cell Cycle, Cell Cycle, Mitotic, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Mus musculus (mouse), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, Sealing of the nuclear envelope (NE) by ESCRT-III, Vesicle-mediated transport
UniProt: Q9D8B3
Entrez ID: 75608
|
Does Knockout of Tnfaip1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Tnfaip1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tnfaip1 (tumor necrosis factor, alpha-induced protein 1 (endothelial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, immune response, negative regulation of Rho protein signal transduction, positive regulation of DNA replication, proteasome-mediated ubiquitin-dependent protein catabolic process, protein homooligomerization, protein ubiquitination, stress fiber assembly; MF: cyclin binding, identical protein binding, small GTPase binding, ubiquitin-protein transferase activity; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, endosome, nucleus
Pathways: RHO GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O70479
Entrez ID: 21927
|
Does Knockout of Bcl9 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Bcl9
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Bcl9 (B cell CLL/lymphoma 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, canonical Wnt signaling pathway, myoblast differentiation, myotube differentiation involved in skeletal muscle regeneration, positive regulation of transcription by RNA polymerase II, skeletal muscle cell differentiation, somatic stem cell population maintenance; MF: beta-catenin binding, transcription coactivator activity; CC: Golgi apparatus, beta-catenin-TCF complex, cis-Golgi network, cytoplasm, nucleus, sarcoplasm
Pathways: Formation of the beta-catenin:TCF transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q9D219
Entrez ID: 77578
|
Does Knockout of Epas1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Epas1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Epas1 (endothelial PAS domain protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, blood vessel remodeling, cell differentiation, cellular response to hypoxia, embryonic placenta development, epithelial cell maturation, erythrocyte differentiation, gene expression, hemopoiesis, intracellular oxygen homeostasis, lung development, mRNA transcription by RNA polymerase II, mitochondrion organization, multicellular organismal-level iron ion homeostasis, myoblast fate commitment, negative regulation of transcription by RNA polymerase II, norepinephrine biosynthetic process, norepinephrine metabolic process, positive regulation of DNA-templated transcription, positive regulation of cold-induced thermogenesis, positive regulation of dopamine biosynthetic process, positive regulation of multicellular organismal process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of heart rate, regulation of protein neddylation, regulation of transcription by RNA polymerase II, response to hypoxia, response to oxidative stress, surfactant homeostasis, tissue remodeling, visual perception; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cis-regulatory region sequence-specific DNA binding, cobalt ion binding, protein binding, protein dimerization activity, protein heterodimerization activity, sequence-specific DNA binding, transcription coactivator binding; CC: cytoplasm, nuclear speck, nucleus, transcription regulator complex
Pathways: Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Metabolism of proteins, Neddylation, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Regulation of gene expression by Hypoxia-inducible Factor, Renal cell carcinoma - Mus musculus (mouse)
UniProt: P97481
Entrez ID: 13819
|
Does Knockout of Srpk1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Srpk1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Srpk1 (serine/arginine-rich protein specific kinase 1)
Type: protein-coding
Summary: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction; protein phosphorylation; and regulation of mRNA processing. Predicted to be located in several cellular components, including chromatin; cytosol; and nuclear speck. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SRPK1 (SRSF protein kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, cell differentiation, chromosome segregation, intracellular signal transduction, mRNA processing, negative regulation of viral genome replication, positive regulation of viral genome replication, protein phosphorylation, regulation of mRNA processing, spliceosomal complex assembly; MF: ATP binding, kinase activity, magnesium ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: chromatin, chromosome, cytoplasm, cytosol, endoplasmic reticulum, nuclear matrix, nuclear speck, nucleoplasm, nucleus, plasma membrane
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: O70551
Entrez ID: 20815
|
Does Knockout of Hip1r in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Hip1r
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hip1r (huntingtin interacting protein 1 related)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, clathrin coat assembly, digestive system development, endocytosis, intrinsic apoptotic signaling pathway, membrane organization, negative regulation of Arp2/3 complex-mediated actin nucleation, negative regulation of actin filament polymerization, negative regulation of apoptotic process, positive regulation of cellular component organization, positive regulation of clathrin coat assembly, positive regulation of clathrin-dependent endocytosis, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, positive regulation of platelet-derived growth factor receptor-beta signaling pathway, positive regulation of transport, postsynapse organization, protein stabilization, receptor-mediated endocytosis, regulation of actin cytoskeleton organization, regulation of apoptotic process, regulation of clathrin-dependent endocytosis, regulation of endocytosis, regulation of gastric acid secretion; MF: SH3 domain binding, actin binding, actin filament binding, clathrin adaptor activity, clathrin binding, clathrin light chain binding, identical protein binding, phosphatidylinositol binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-4,5-bisphosphate binding, phospholipid binding, protein binding, protein heterodimerization activity, protein homodimerization activity; CC: apical plasma membrane, cell cortex, clathrin-coated pit, clathrin-coated vesicle, clathrin-coated vesicle membrane, cortical actin cytoskeleton, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, dendrite cytoplasm, dendritic spine, endomembrane system, glutamatergic synapse, membrane, mitochondrion, neuronal cell body, perinuclear region of cytoplasm, plasma membrane, postsynapse, postsynaptic density, postsynaptic endocytic zone, ruffle membrane, synaptic membrane
Pathways: Clathrin-mediated endocytosis, Golgi Associated Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q9JKY5
Entrez ID: 29816
|
Does Knockout of Ocln in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Ocln
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ocln (occludin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicellular tight junction assembly, cell-cell junction organization, negative regulation of gene expression, positive regulation of D-glucose import, positive regulation of blood-brain barrier permeability, positive regulation of gene expression, regulation of D-glucose transmembrane transport, response to interleukin-18, tight junction organization; MF: protein binding, protein domain specific binding; CC: anchoring junction, apical plasma membrane, apicolateral plasma membrane, bicellular tight junction, cell junction, cell surface, cell-cell junction, cytoplasmic vesicle, endocytic vesicle, lateral plasma membrane, lysosomal membrane, membrane, plasma membrane, protein-containing complex, tight junction
Pathways: Cell adhesion molecules - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: Q61146
Entrez ID: 18260
|
Does Knockout of Rbm11 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Rbm11
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Rbm11 (RNA binding motif protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cell differentiation, cellular response to oxidative stress, mRNA processing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, nucleic acid binding, poly(U) RNA binding, protein homodimerization activity, single-stranded RNA binding; CC: nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q80YT9
Entrez ID: 224344
|
Does Knockout of Pcnt in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Pcnt
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pcnt (pericentrin (kendrin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain morphogenesis, camera-type eye development, cerebellar cortex morphogenesis, cilium assembly, embryonic brain development, embryonic heart tube development, head development, in utero embryonic development, kidney development, limb morphogenesis, microtubule cytoskeleton organization, microtubule nucleation, mitotic spindle organization, multicellular organism growth, negative regulation of apoptotic process, neural precursor cell proliferation, neuron migration, olfactory bulb development, positive regulation of intracellular protein transport, signal transduction, spindle organization, vasculature development; MF: calmodulin binding, molecular adaptor activity, protein binding; CC: centriolar satellite, centriole, centrosome, ciliary basal body, cilium, cis-Golgi network, cytoplasm, cytoskeleton, cytosol, intercellular bridge, microtubule, microtubule organizing center, motile cilium, pericentriolar material
Pathways: AURKA Activation by TPX2, Aggrephagy, Anchoring of the basal body to the plasma membrane, Autophagy, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Macroautophagy, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Selective autophagy
UniProt: P48725
Entrez ID: 18541
|
Does Knockout of Tmem132c in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Tmem132c
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmem132c (transmembrane protein 132C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of phosphatase activity
Pathways:
UniProt: Q8CEF9
Entrez ID: 208213
|
Does Knockout of Qser1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Qser1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Qser1 (glutamine and serine rich 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, chromosome
Pathways:
UniProt: A0A338P6K9
Entrez ID: 99003
|
Does Knockout of Ttyh2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Ttyh2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ttyh2 (tweety family member 2)
Type: protein-coding
Summary: Enables calcium ion binding activity and volume-sensitive chloride channel activity. Involved in L-glutamate transmembrane transport. Located in plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; olfactory epithelium; retina layer; and submandibular gland primordium mesenchyme. Orthologous to human TTYH2 (tweety family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: L-glutamate transmembrane transport, chloride transmembrane transport, chloride transport, monoatomic ion transmembrane transport, monoatomic ion transport; MF: calcium ion binding, chloride channel activity, intracellularly calcium-gated chloride channel activity, volume-sensitive anion channel activity, volume-sensitive chloride channel activity; CC: chloride channel complex, membrane, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q3TH73
Entrez ID: 117160
|
Does Knockout of Kdelr1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Kdelr1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kdelr1 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell apoptotic process, T cell differentiation, protein retention in ER lumen, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: ER retention sequence binding, KDEL sequence binding; CC: COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cis-Golgi network, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q99JH8
Entrez ID: 68137
|
Does Knockout of Evpl in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Evpl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Evpl (envoplakin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermediate filament cytoskeleton organization, keratinization, keratinocyte differentiation, regulation of antibacterial peptide production, wound healing; CC: anchoring junction, cornified envelope, cytoplasm, cytoskeleton, cytosol, desmosome, intermediate filament, intermediate filament cytoskeleton, membrane
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q9D952
Entrez ID: 14027
|
Does Knockout of Retnlg in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Retnlg
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Retnlg (resistin like gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: myeloid dendritic cell chemotaxis, signal transduction; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8K426
Entrez ID: 245195
|
Does Knockout of Zfp397 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Zfp397
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Zfp397 (zinc finger protein 397)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein heterodimerization activity, protein homodimerization activity, zinc ion binding; CC: cytoplasm, cytosol, microtubule cytoskeleton, nucleolus, nucleus, plasma membrane
Pathways:
UniProt: A0A286YCD9, Q7TNK4
Entrez ID: 69256
|
Does Knockout of Nt5c3 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Nt5c3
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Nt5c3 (5'-nucleotidase, cytosolic III)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP catabolic process, UMP catabolic process, adenosine metabolic process, dCMP catabolic process, dTMP catabolic process, dUMP catabolic process, defense response to virus, nucleotide metabolic process; MF: 5'-nucleotidase activity, hydrolase activity, magnesium ion binding, metal ion binding, nucleotide binding, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, mitochondrion, nuclear body, nucleoplasm
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Purine metabolism - Mus musculus (mouse), Pyrimidine catabolism, Pyrimidine metabolism - Mus musculus (mouse)
UniProt: Q9D020
Entrez ID: 107569
|
Does Knockout of Ckap5 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ckap5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ckap5 (cytoskeleton associated protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA transport, cell division, central nervous system myelin formation, centrosome cycle, centrosome duplication, cytoplasmic translation, dendritic spine maintenance, establishment or maintenance of microtubule cytoskeleton polarity, excitatory postsynaptic potential, habituation, locomotory behavior, long-term synaptic potentiation, mRNA localization resulting in post-transcriptional regulation of gene expression, microtubule polymerization, mitotic spindle organization, positive regulation of endocytosis, positive regulation of microtubule nucleation, protein-RNA complex assembly, protein-containing complex organization, spindle organization, visual learning; MF: microtubule binding, microtubule plus end polymerase, microtubule plus-end binding, ribonucleoprotein complex binding, tubulin binding; CC: centrosome, chromosome, chromosome, centromeric region, ciliary basal body, cilium, cytoplasm, cytoskeleton, dendrite, kinetochore, microtubule cytoskeleton, microtubule plus-end, mitotic spindle, neuronal ribonucleoprotein granule, nucleolus, perikaryon, plasma membrane, postsynapse, protein-containing complex, spindle, spindle pole
Pathways: AURKA Activation by TPX2, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, EML4 and NUDC in mitotic spindle formation, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Organelle biogenesis and maintenance, RHO GTPase Effectors, RHO GTPases Activate Formins, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: A2AGT5
Entrez ID: 75786
|
Does Knockout of Erbin in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Erbin
|
cell cycle progression
|
breast epithelium
|
Gene: Erbin (Erbb2 interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to tumor necrosis factor, intracellular signal transduction, negative regulation of monocyte chemotactic protein-1 production, negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, protein targeting, regulation of gene expression, regulation of postsynaptic membrane neurotransmitter receptor levels, response to lipopolysaccharide, response to muramyl dipeptide; MF: protein binding, signaling receptor binding; CC: anchoring junction, basolateral plasma membrane, cell junction, cytoplasm, glutamatergic synapse, hemidesmosome, membrane, neuromuscular junction, nuclear membrane, nuclear speck, nucleus, plasma membrane, postsynapse, postsynaptic specialization
Pathways: Downregulation of ERBB2 signaling, Drug-mediated inhibition of ERBB2 signaling, NOD-like receptor signaling pathway - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by ERBB2, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q80TH2
Entrez ID: 59079
|
Does Knockout of Flad1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Flad1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Flad1 (flavin adenine dinucleotide synthetase 1)
Type: protein-coding
Summary: Enables FMN adenylyltransferase activity. Involved in flavin adenine dinucleotide biosynthetic process and riboflavin metabolic process. Is active in cytosol. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: FAD biosynthetic process, flavin adenine dinucleotide biosynthetic process, riboflavin metabolic process; MF: ATP binding, FAD diphosphatase activity, FMN adenylyltransferase activity, catalytic activity, identical protein binding, nucleotide binding, nucleotidyltransferase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrial matrix, nucleus, plasma membrane
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Riboflavin metabolism - Mus musculus (mouse), Vitamin B2 (riboflavin) metabolism, flavin biosynthesis IV (mammalian), riboflavin, FMN and FAD transformations
UniProt: Q8R123
Entrez ID: 319945
|
Does Knockout of Nuak1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Nuak1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nuak1 (NUAK family, SNF1-like kinase, 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cell adhesion, protein phosphorylation, regulation of cell adhesion, regulation of cellular senescence; MF: ATP binding, kinase activity, nucleotide binding, p53 binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, fibrillar center, microtubule cytoskeleton, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q641K5
Entrez ID: 77976
|
Does Knockout of Lyl1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Lyl1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Lyl1 (lymphoblastomic leukemia 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, blood vessel maturation, definitive hemopoiesis, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein dimerization activity
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P27792
Entrez ID: 17095
|
Does Knockout of Scgb2b2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Scgb2b2
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Scgb2b2 (secretoglobin, family 2B, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region, extracellular space
Pathways:
UniProt: A0A0U1RPN9, G5E8B4
Entrez ID: 381970
|
Does Knockout of Fanci in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,525
|
Knockout
|
Fanci
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Fanci (Fanconi anemia, complementation group I)
Type: protein-coding
Summary: Predicted to enable DNA polymerase binding activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within positive regulation of protein ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of DNA repair complex and Fanconi anaemia nuclear complex. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group I; and female breast cancer. Orthologous to human FANCI (FA complementation group I). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, positive regulation of protein ubiquitination; MF: DNA polymerase binding; CC: DNA repair complex, Fanconi anaemia nuclear complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse)
UniProt: Q8K368
Entrez ID: 208836
|
Does Knockout of Hpse2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Hpse2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hpse2 (heparanase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extracellular matrix organization, positive regulation of cell population proliferation; MF: heparan sulfate proteoglycan binding, hydrolase activity, acting on glycosyl bonds; CC: extracellular matrix, extracellular region, extracellular space, membrane
Pathways: Glycosaminoglycan degradation - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG degradation, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Proteoglycans in cancer - Mus musculus (mouse)
UniProt: B2RY83
Entrez ID: 545291
|
Does Knockout of Fam193b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Fam193b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fam193b (family with sequence similarity 193, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q3U2K0
Entrez ID: 212483
|
Does Knockout of Tssk4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Tssk4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tssk4 (testis-specific serine kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, fertilization, flagellated sperm motility, peptidyl-serine phosphorylation, peptidyl-threonine autophosphorylation, positive regulation of CREB transcription factor activity, protein phosphorylation, spermatid development, spermatogenesis; MF: ATP binding, identical protein binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: acrosomal vesicle, cell projection, cilium, cytoplasmic vesicle, motile cilium, sperm flagellum
Pathways:
UniProt: Q9D411
Entrez ID: 71099
|
Does Knockout of Fyn in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Fyn
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fyn (Fyn proto-oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled glutamate receptor signaling pathway, T cell receptor signaling pathway, activated T cell proliferation, adaptive immune response, cell differentiation, cell surface receptor protein tyrosine kinase signaling pathway, cell surface receptor signaling pathway, cellular response to L-glutamate, cellular response to amyloid-beta, cellular response to glycine, cellular response to growth factor stimulus, cellular response to hydrogen peroxide, cellular response to peptide hormone stimulus, cellular response to platelet-derived growth factor stimulus, cellular response to transforming growth factor beta stimulus, dendrite morphogenesis, detection of mechanical stimulus involved in sensory perception of pain, forebrain development, gene expression, heart process, immune system process, intracellular signal transduction, modulation of chemical synaptic transmission, myelination, natural killer cell activation, negative regulation of angiogenesis, negative regulation of dendritic spine maintenance, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of gene expression, negative regulation of hydrogen peroxide biosynthetic process, negative regulation of neuron apoptotic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of protein catabolic process, negative regulation of protein ubiquitination, neuron migration, peptidyl-tyrosine phosphorylation, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to nucleus, positive regulation of protein targeting to membrane, positive regulation of tyrosine phosphorylation of STAT protein, reelin-mediated signaling pathway, regulation of calcium ion import across plasma membrane, regulation of cell shape, regulation of glutamate receptor signaling pathway, response to amyloid-beta, response to cocaine, response to ethanol, response to singlet oxygen, response to xenobiotic stimulus; MF: ATP binding, CD4 receptor binding, CD8 receptor binding, G protein-coupled receptor binding, T cell receptor binding, alpha-tubulin binding, disordered domain specific binding, enzyme binding, ephrin receptor binding, growth factor receptor binding, identical protein binding, kinase activity, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, peptide hormone receptor binding, phosphatidylinositol 3-kinase binding, phospholipase activator activity, phospholipase binding, protein binding, protein kinase activity, protein tyrosine kinase activity, protein-containing complex binding, scaffold protein binding, signaling receptor binding, tau protein binding, transferase activity, transmembrane transporter binding, tubulin binding, type 5 metabotropic glutamate receptor binding; CC: Schaffer collateral - CA1 synapse, actin filament, cell body, cell periphery, cytoplasm, cytosol, dendrite, endosome, glial cell projection, glutamatergic synapse, membrane, membrane raft, mitochondrion, nucleus, perikaryon, perinuclear endoplasmic reticulum, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, postsynaptic density, intracellular component
Pathways: Activated NTRK2 signals through FYN, Adaptive Immune System, Adherens junction - Mus musculus (mouse), Adherens junctions interactions, Axon guidance, Axon guidance - Mus musculus (mouse), C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, CD28 dependent PI3K/Akt signaling, CD28 dependent Vav1 pathway, CRMPs in Sema3A signaling, Cell junction organization, Cell surface interactions at the vascular wall, Cell-Cell communication, Cell-cell junction organization, Cholinergic synapse - Mus musculus (mouse), Co-inhibition by CTLA4, Co-stimulation by CD28, Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, DCC mediated attractive signaling, Dectin-2 family, Degradation of CDH1, Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA-mediated growth cone collapse, EPHB-mediated forward signaling, Ephrin signaling, FCGR activation, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Focal adhesion - Mus musculus (mouse), GPVI-mediated activation cascade, Hemostasis, Immune System, Innate Immune System, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK1/MAPK3 signaling, NCAM signaling for neurite out-growth, NTRK2 activates RAC1, Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Nephrin family interactions, Nervous system development, Netrin-1 signaling, Osteoclast differentiation - Mus musculus (mouse), PECAM1 interactions, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Phospholipase D signaling pathway - Mus musculus (mouse), Platelet Adhesion to exposed collagen, Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Prion disease - Mus musculus (mouse), RAF/MAP kinase cascade, Reelin signalling pathway, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of KIT signaling, Regulation of T cell activation by CD28 family, Regulation of signaling by CBL, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, Sema3A PAK dependent Axon repulsion, Semaphorin interactions, Signal Transduction, Signaling by ERBB2, Signaling by Interleukins, Signaling by NTRK2 (TRKB), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling by VEGF, Sphingolipid signaling pathway - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Viral myocarditis - Mus musculus (mouse)
UniProt: P39688
Entrez ID: 14360
|
Does Knockout of Lrif1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Lrif1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Lrif1 (ligand dependent nuclear receptor interacting factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dosage compensation by inactivation of X chromosome, regulation of DNA-templated transcription; MF: nuclear retinoic acid receptor binding, protein binding; CC: Barr body, centriolar satellite, chromosome, chromosome, telomeric region, nuclear matrix, nucleoplasm, nucleus
Pathways:
UniProt: Q8CDD9
Entrez ID: 321000
|
Does Knockout of Atp6v1b1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Atp6v1b1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Atp6v1b1 (ATPase, H+ transporting, lysosomal V1 subunit B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, adult behavior, calcium ion homeostasis, chloride ion homeostasis, inner ear morphogenesis, monoatomic ion transport, olfactory behavior, ossification, pH reduction, potassium ion homeostasis, prostaglandin metabolic process, proton transmembrane transport, regulation of gene expression, regulation of pH, renal sodium excretion, renal sodium ion transport, renal tubular secretion, renal water homeostasis, sensory perception of sound, synaptic vesicle lumen acidification, vacuolar acidification, vacuolar proton-transporting V-type ATPase complex assembly; MF: ATP binding, nucleotide binding, protein-containing complex binding, proton transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, basolateral plasma membrane, cytoplasm, cytosol, extrinsic component of synaptic vesicle membrane, lateral plasma membrane, membrane, microvillus, plasma membrane, proton-transporting V-type ATPase, V1 domain, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q91YH6
Entrez ID: 110935
|
Does Knockout of Gm4491 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Gm4491
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gm4491 (predicted gene 4491)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Ctbs in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Ctbs
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ctbs (chitobiase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, chitin catabolic process, oligosaccharide catabolic process; MF: chitin binding, chitinase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds
Pathways:
UniProt: Q8R242
Entrez ID: 74245
|
Does Knockout of Mir669c in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mir669c
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mir669c (microRNA 669c)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 735273
|
Does Knockout of Supt3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Supt3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Supt3 (SPT3, SAGA and STAGA complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: protein heterodimerization activity, transcription coactivator activity; CC: SAGA complex, nucleoplasm, nucleus, transcription factor TFTC complex
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: B0QZW4, Q8BVY4, B0QZW5
Entrez ID: 109115
|
Does Knockout of Sptlc1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Sptlc1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sptlc1 (serine palmitoyltransferase, long chain base subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, lipid metabolic process, positive regulation of lipophagy, regulation of fat cell apoptotic process, sphinganine biosynthetic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingomyelin biosynthetic process, sphingosine biosynthetic process; MF: acyltransferase activity, protein binding, pyridoxal phosphate binding, serine C-palmitoyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, serine palmitoyltransferase complex
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), ceramide biosynthesis
UniProt: O35704
Entrez ID: 268656
|
Does Knockout of Arpc4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Arpc4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Arpc4 (actin related protein 2/3 complex, subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin filament polymerization; MF: actin binding, actin filament binding, enzyme binding, protein-macromolecule adaptor activity, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, actin cytoskeleton, cell projection, cytoplasm, cytoskeleton, nucleus, site of double-strand break
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Membrane Trafficking, Nervous system development, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: P59999
Entrez ID: 68089
|
Does Knockout of Isca2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Isca2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Isca2 (iron-sulfur cluster assembly 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: iron-sulfur cluster assembly, protein maturation; MF: 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, identical protein binding, iron ion binding, iron-sulfur cluster binding, metal ion binding; CC: mitochondrial [4Fe-4S] assembly complex, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis
UniProt: Q9DCB8
Entrez ID: 74316
|
Does Knockout of Pak1ip1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Pak1ip1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pak1ip1 (PAK1 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of signal transduction, regulation of signal transduction by p53 class mediator, ribosomal large subunit biogenesis, ribosome biogenesis, roof of mouth development; MF: protein binding, protein kinase inhibitor activity; CC: nucleolus, nucleus
Pathways:
UniProt: Q9DCE5
Entrez ID: 68083
|
Does Knockout of Rbm5 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Rbm5
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Rbm5 (RNA binding motif protein 5)
Type: protein-coding
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of apoptotic process; regulation of alternative mRNA splicing, via spliceosome; and spliceosomal complex assembly. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Is expressed in central nervous system; lung; sensory organ; and testis. Orthologous to human RBM5 (RNA binding motif protein 5). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: RNA splicing, apoptotic process, mRNA processing, mRNA splicing, via spliceosome, positive regulation of apoptotic process, regulation of alternative mRNA splicing, via spliceosome, spliceosomal complex assembly; MF: RNA binding, mRNA binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q91YE7
Entrez ID: 83486
|
Does Knockout of E2f2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
E2f2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: E2f2 (E2F transcription factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intrinsic apoptotic signaling pathway by p53 class mediator, lens fiber cell apoptotic process, negative regulation of sprouting angiogenesis, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, Rb-E2F complex, nucleus, transcription regulator complex
Pathways: Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cyclin D associated events in G1, Epstein-Barr virus infection - Mus musculus (mouse), G1 Phase, Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Non-small cell lung cancer - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse)
UniProt: P56931
Entrez ID: 242705
|
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