prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Nipa2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Nipa2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nipa2 (non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: magnesium ion transmembrane transport, magnesium ion transport, monoatomic ion transport; MF: magnesium ion transmembrane transporter activity, protein binding; CC: early endosome, endosome, membrane, plasma membrane
Pathways: Miscellaneous transport and binding events, Transport of small molecules
UniProt: Q9JJC8
Entrez ID: 93790
|
Does Knockout of Naa50 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Naa50
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Naa50 (N(alpha)-acetyltransferase 50, NatE catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-terminal protein amino acid acetylation, chromatin remodeling, establishment of mitotic sister chromatid cohesion, mitotic sister chromatid cohesion, mitotic sister chromatid cohesion, centromeric, post-translational protein modification; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, histone H4 acetyltransferase activity, protein N-terminal-methionine acetyltransferase activity, protein binding, protein-N-terminal amino-acid acetyltransferase activity, protein-lysine-acetyltransferase activity, transferase activity; CC: NatA complex, cytoplasm, cytosol, nucleolus, nucleus
Pathways:
UniProt: Q6PGB6
Entrez ID: 72117
|
Does Knockout of Psmb5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Psmb5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Psmb5 (proteasome (prosome, macropain) subunit, beta type 5)
Type: protein-coding
Summary: Enables peptidase activity. Acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process and response to oxidative stress. Part of proteasome core complex. Is expressed in embryo. Orthologous to human PSMB5 (proteasome 20S subunit beta 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, proteolysis involved in protein catabolic process, response to oxidative stress; MF: endopeptidase activity, hydrolase activity, peptidase activity, threonine-type endopeptidase activity; CC: centrosome, cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: O55234
Entrez ID: 19173
|
Does Knockout of Kif23 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Kif23
|
response to virus
|
Microglial Cell Line
|
Gene: Kif23 (kinesin family member 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule-based movement, mitotic cytokinesis, mitotic spindle midzone assembly, positive regulation of cytokinesis; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, nucleotide binding; CC: Flemming body, centralspindlin complex, centrosome, cytoplasm, cytoskeleton, intercellular bridge, kinesin complex, microtubule, midbody, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: Adaptive Immune System, COPI-dependent Golgi-to-ER retrograde traffic, Cell Cycle, Cell Cycle, Mitotic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, M Phase, MHC class II antigen presentation, Membrane Trafficking, MicroRNAs in cancer - Mus musculus (mouse), Mitotic Telophase/Cytokinesis, Vesicle-mediated transport
UniProt: E9Q5G3
Entrez ID: 71819
|
Does Knockout of Plch1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Plch1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Plch1 (phospholipase C, eta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, lipid catabolic process, lipid metabolic process, phosphatidylinositol metabolic process, phosphatidylinositol-mediated signaling, release of sequestered calcium ion into cytosol, signal transduction; MF: calcium ion binding, calcium-dependent phospholipase C activity, hydrolase activity, metal ion binding, phosphatidylinositol-4,5-bisphosphate phospholipase C activity, phosphoric diester hydrolase activity; CC: cytoplasm, cytosol, membrane
Pathways: D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, D-<i>myo</i>-inositol-5-phosphate metabolism, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, PIP metabolism, Synthesis of IP3 and IP4 in the cytosol, phospholipases
UniProt: Q4KWH5
Entrez ID: 269437
|
Does Knockout of Ssbp3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ssbp3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ssbp3 (single-stranded DNA binding protein 3)
Type: protein-coding
Summary: This gene encodes a member of the Ssdp (sequence-specific single-stranded DNA binding protein) family of proteins. The encoded protein binds specifically to single-stranded pyrimidine-rich DNA elements. The encoded protein has been shown to be important for head development and may play a role in the differentiation of spinal interneurons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cell differentiation, head development, head morphogenesis, hematopoietic progenitor cell differentiation, mesendoderm development, midbrain-hindbrain boundary initiation, positive regulation of DNA-templated transcription, positive regulation of anterior head development, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, prechordal plate formation, protein-containing complex assembly; MF: DNA binding, protein binding, single-stranded DNA binding, transcription coactivator activity; CC: nucleus, protein-containing complex, transcription regulator complex
Pathways:
UniProt: Q9D032
Entrez ID: 72475
|
Does Knockout of Ola1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Ola1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ola1 (Obg-like ATPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process; MF: ATP binding, ATP hydrolysis activity, GTP binding, hydrolase activity, metal ion binding, nucleotide binding, ribosomal large subunit binding, ribosome binding; CC: centrosome, cytoplasm, cytosol, nucleolus, nucleus
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q9CZ30
Entrez ID: 67059
|
Does Knockout of Atp6v0e in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Atp6v0e
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Atp6v0e (ATPase, H+ transporting, lysosomal V0 subunit E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, transmembrane transport; MF: proton-transporting ATPase activity, rotational mechanism; CC: membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V0 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules
UniProt: Q9CQD8
Entrez ID: 11974
|
Does Knockout of Ankrd46 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,158
|
Knockout
|
Ankrd46
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ankrd46 (ankyrin repeat domain 46)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BTZ5
Entrez ID: 68839
|
Does Knockout of Tox in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Tox
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Tox (thymocyte selection-associated high mobility group box)
Type: protein-coding
Summary: Enables chromatin DNA binding activity. Involved in several processes, including alpha-beta T cell lineage commitment; cerebral cortex neuron differentiation; and regulation of positive thymic T cell selection. Acts upstream of or within hematopoietic or lymphoid organ development; lymphocyte differentiation; and positive regulation of natural killer cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human TOX (thymocyte selection associated high mobility group box). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment, CD4-positive, alpha-beta T cell lineage commitment, CD8-positive, alpha-beta T cell lineage commitment, NK T cell lineage commitment, Peyer's patch development, cerebral cortex neuron differentiation, chromatin organization, leukocyte differentiation, lymph node development, lymphocyte differentiation, natural killer cell differentiation, nervous system development, positive regulation of natural killer cell differentiation, positive regulation of neural precursor cell proliferation, positive regulation of neuron projection development, positive regulation of transcription by RNA polymerase II, regulation of positive thymic T cell selection, regulation of transcription by RNA polymerase II; MF: DNA binding, chromatin DNA binding; CC: nucleus
Pathways:
UniProt: Q66JW3
Entrez ID: 252838
|
Does Knockout of Nvl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Nvl
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nvl (nuclear VCP-like)
Type: protein-coding
Summary: Predicted to enable ATP binding activity; ATP hydrolysis activity; and preribosome binding activity. Predicted to be involved in rRNA processing; regulation of protein localization to nucleolus; and ribosomal large subunit biogenesis. Predicted to be located in nucleoplasm. Predicted to be part of nuclear exosome (RNase complex) and telomerase holoenzyme complex. Predicted to be active in nucleus. Predicted to colocalize with nucleolus. Orthologous to human NVL (nuclear VCP like). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: positive regulation of protein binding, positive regulation of telomere maintenance, rRNA processing, regulation of protein localization to nucleolus, ribosomal large subunit biogenesis, ribosome biogenesis, telomerase holoenzyme complex assembly; MF: ATP binding, ATP hydrolysis activity, nucleotide binding, preribosome binding; CC: nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus, telomerase holoenzyme complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9DBY8
Entrez ID: 67459
|
Does Knockout of Synj2bp in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Synj2bp
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Synj2bp (synaptojanin 2 binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, cytoplasm organization, endocytosis, intracellular distribution of mitochondria, negative regulation of ERK1 and ERK2 cascade, negative regulation of activin receptor signaling pathway, negative regulation of angiogenesis, negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, negative regulation of sprouting angiogenesis, positive regulation of activin receptor signaling pathway, positive regulation of protein localization to cell surface, positive regulation of receptor internalization, protein targeting, regulation of Notch signaling pathway, regulation of endocytosis, regulation of receptor internalization; MF: protein binding, type II activin receptor binding; CC: cell surface, cytoplasm, membrane, mitochondrial outer membrane, mitochondrion, perinuclear region of cytoplasm
Pathways:
UniProt: Q9D6K5
Entrez ID: 24071
|
Does Knockout of Rangap1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Rangap1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rangap1 (RAN GTPase activating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to peptide hormone stimulus, cellular response to vasopressin, negative regulation of protein export from nucleus, nuclear export, protein sumoylation, response to axon injury, signal transduction; MF: GTPase activator activity, RNA binding, small GTPase binding, ubiquitin protein ligase binding; CC: SUMO ligase complex, aggresome, axon cytoplasm, chromosome, chromosome, centromeric region, cytoplasm, cytoplasmic periphery of the nuclear pore complex, cytoskeleton, cytosol, dendrite, kinetochore, mitotic spindle, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore cytoplasmic filaments, nucleoplasm, nucleus, perinuclear region of cytoplasm, spindle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, SUMOylation of nuclear envelope proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P46061
Entrez ID: 19387
|
Does Knockout of Htra3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Htra3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Htra3 (HtrA serine peptidase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of BMP signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, proteolysis; MF: endopeptidase activity, hydrolase activity, identical protein binding, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity
Pathways:
UniProt: Q9D236
Entrez ID: 78558
|
Does Knockout of Gtf2h2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Gtf2h2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gtf2h2 (general transcription factor II H, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, nucleotide-excision repair, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: RNA polymerase II general transcription initiation factor activity, metal ion binding, zinc ion binding; CC: core TFIIH complex portion of holo TFIIH complex, nuclear speck, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Mus musculus (mouse), DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral carcinogenesis - Mus musculus (mouse), mRNA Capping
UniProt: Q9JIB4
Entrez ID: 23894
|
Does Knockout of Podnl1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Podnl1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Podnl1 (podocan-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: Q6P3Y9
Entrez ID: 244550
|
Does Knockout of Prkg2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Prkg2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Prkg2 (protein kinase, cGMP-dependent, type II)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular hypotonic response, circadian regulation of gene expression, circadian rhythm, negative regulation of cell volume, negative regulation of chloride transport, positive regulation of chondrocyte differentiation, positive regulation of protein localization, positive regulation of small molecule metabolic process, protein localization to plasma membrane, signal transduction; MF: ATP binding, cGMP binding, cGMP-dependent protein kinase activity, identical protein binding, kinase activity, mitogen-activated protein kinase binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: apical plasma membrane, membrane, nuclear membrane, plasma membrane
Pathways: Circadian entrainment - Mus musculus (mouse), Gap junction - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Olfactory transduction - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q8C4R2, Q8CAH8, Q3TMJ2, E9QPH0, A0A0G2JEE8
Entrez ID: 19092
|
Does Knockout of Rdh1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Rdh1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Rdh1 (retinol dehydrogenase 1 (all trans))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: androgen biosynthetic process, positive regulation of retinoic acid biosynthetic process, retinoic acid metabolic process, retinoid metabolic process, retinol metabolic process, steroid metabolic process; MF: all-trans-retinol dehydrogenase (NAD+) activity, androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, oxidoreductase activity, steroid dehydrogenase activity; CC: endoplasmic reticulum membrane, intracellular membrane-bounded organelle, organelle membrane
Pathways: RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, The canonical retinoid cycle in rods (twilight vision), Visual phototransduction
UniProt: Q8VIJ7, Q8CGV4
Entrez ID: 107605
|
Does Knockout of Ifna12 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Ifna12
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ifna12 (interferon alpha 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways: Alcoholic liver disease - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Cytosolic DNA-sensing pathway - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of IFNA/IFNB signaling, Toll-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q80SS5
Entrez ID: 242519
|
Does Knockout of Cdh20 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Cdh20
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cdh20 (cadherin 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adherens junction organization, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, homophilic cell adhesion via plasma membrane adhesion molecules; MF: beta-catenin binding, cadherin binding, calcium ion binding, metal ion binding; CC: adherens junction, catenin complex, membrane, plasma membrane
Pathways:
UniProt: Q9Z0M3
Entrez ID: 23836
|
Does Knockout of Chd4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Chd4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Chd4 (chromodomain helicase DNA binding protein 4)
Type: protein-coding
Summary: Enables DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including double-strand break repair via homologous recombination; negative regulation of macromolecule biosynthetic process; and terminal button organization. Located in nucleus. Part of NuRD complex and protein-DNA complex. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; genitourinary system; and nervous system. Used to study left ventricular noncompaction. Human ortholog(s) of this gene implicated in Sifrim-Hitz-Weiss syndrome; colorectal cancer (multiple); lung cancer (multiple); and lymphoma. Orthologous to human CHD4 (chromodomain helicase DNA binding protein 4). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: chromatin organization, chromatin remodeling, double-strand break repair via homologous recombination, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, oxygen transport, positive regulation of DNA-templated transcription, regulation of cell fate specification, regulation of stem cell differentiation, regulation of synapse assembly, terminal button organization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent chromatin remodeler activity, DNA binding, DNA-binding transcription factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, histone binding, histone deacetylase binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding, transcription coregulator binding, transcription corepressor activity, zinc ion binding; CC: NuRD complex, RNA polymerase II transcription regulator complex, centrosome, cerebellar granule cell to Purkinje cell synapse, chromatin, chromosome, telomeric region, cytoplasm, cytoskeleton, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, site of DNA damage
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, Human papillomavirus infection - Mus musculus (mouse), Intracellular signaling by second messengers, NGF-stimulated transcription, Nuclear Events (kinase and transcription factor activation), PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Transcriptional Regulation by TP53, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q6PDQ2
Entrez ID: 107932
|
Does Knockout of Mamdc2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Mamdc2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Mamdc2 (MAM domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endoplasmic reticulum, extracellular matrix, extracellular region, interstitial matrix, membrane
Pathways:
UniProt: Q8CG85
Entrez ID: 71738
|
Does Knockout of Trnp1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Trnp1
|
phagocytosis
|
macrophage
|
Gene: Trnp1 (TMF1-regulated nuclear protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellar cortex morphogenesis, nervous system development, neural precursor cell proliferation, regulation of cell cycle, regulation of cell population proliferation; MF: DNA binding, protein binding; CC: euchromatin, nucleus
Pathways:
UniProt: Q80ZI1
Entrez ID: 69539
|
Does Knockout of Eomes in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Eomes
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Eomes (eomesodermin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, alpha-beta T cell differentiation involved in immune response, adaptive immune response, anatomical structure morphogenesis, astrocyte differentiation, blastocyst development, brain development, cardioblast differentiation, cell differentiation, cell differentiation involved in embryonic placenta development, cerebral cortex development, cerebral cortex neuron differentiation, cerebral cortex regionalization, chromatin remodeling, endoderm development, endoderm formation, endodermal cell fate specification, forebrain neuron differentiation, gastrulation, gene expression, immune system process, mesendoderm development, mesoderm formation, mesodermal to mesenchymal transition involved in gastrulation, negative regulation of transcription by RNA polymerase II, neurogenesis, neuron differentiation, neuron migration, olfactory bulb development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II, skeletal muscle cell differentiation, stem cell population maintenance, trophectodermal cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription corepressor activity; CC: chromatin, nucleoplasm, nucleus
Pathways:
UniProt: O54839
Entrez ID: 13813
|
Does Knockout of Traf3ip1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Traf3ip1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Traf3ip1 (TRAF3 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, cell projection organization, cilium assembly, dorsal/ventral neural tube patterning, embryonic camera-type eye development, embryonic digit morphogenesis, embryonic heart tube development, intraciliary anterograde transport, intraciliary transport, kidney development, morphogenesis of a polarized epithelium, negative regulation of defense response to virus, negative regulation of interferon-beta production, negative regulation of protein-containing complex assembly, negative regulation of smoothened signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of type I interferon production, neural tube patterning, post-anal tail morphogenesis, regulation of microtubule cytoskeleton organization, system development; MF: microtubule binding, protein binding, signaling receptor binding, tubulin binding; CC: axoneme, cell projection, centrosome, ciliary basal body, ciliary base, ciliary tip, ciliary transition zone, cilium, cytoplasm, cytoskeleton, cytosol, fibrillar center, intraciliary transport particle B, microtubule cytoskeleton, nuclear body, nucleoplasm
Pathways: Cilium Assembly, Intraflagellar transport, Organelle biogenesis and maintenance
UniProt: Q149C2
Entrez ID: 74019
|
Does Knockout of Cox6a1 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Cox6a1
|
cell proliferation
|
Regulatory T cell
|
Gene: Cox6a1 (cytochrome c oxidase subunit 6A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; MF: enzyme regulator activity, oxidoreductase activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, myelin sheath, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, aerobic respiration -- electron donor II
UniProt: P43024
Entrez ID: 12861
|
Does Knockout of Ctcf in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Ctcf
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Ctcf (CCCTC-binding factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cardiac muscle cell development, cardiac muscle cell differentiation, chromatin looping, chromatin organization, chromosome segregation, epigenetic regulation of gene expression, gene expression, genomic imprinting, heart development, in utero embryonic development, mitochondrion organization, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of miRNA transcription, positive regulation of transcription by RNA polymerase II, protein localization to chromosome, centromeric region, random inactivation of X chromosome, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, chromatin insulator sequence binding, chromatin loop anchoring activity, cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coregulator binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, dense fibrillar component, granular component, male germ cell nucleus, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q61164
Entrez ID: 13018
|
Does Knockout of Alas2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Alas2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Alas2 (aminolevulinic acid synthase 2, erythroid)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: erythrocyte development, erythrocyte differentiation, heme B biosynthetic process, heme biosynthetic process, hemoglobin biosynthetic process, intracellular iron ion homeostasis, porphyrin-containing compound metabolic process, protoporphyrinogen IX biosynthetic process, response to hypoxia, tetrapyrrole biosynthetic process; MF: 5-aminolevulinate synthase activity, acyltransferase activity, coenzyme A binding, pyridoxal phosphate binding, transferase activity; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Glycine, serine and threonine metabolism - Mus musculus (mouse), Heme biosynthesis, Metabolism, Metabolism of porphyrins, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, tetrapyrrole biosynthesis II
UniProt: P08680
Entrez ID: 11656
|
Does Knockout of Snrpd1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Snrpd1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Snrpd1 (small nuclear ribonucleoprotein D1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity and U1 snRNP binding activity. Predicted to be involved in spliceosomal snRNP assembly. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in connective tissue disease; nephritis; proteinuria; and systemic lupus erythematosus. Orthologous to human SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal snRNP assembly; MF: RNA binding, U1 snRNP binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, commitment complex, cytoplasm, cytosol, methylosome, nucleus, pICln-Sm protein complex, precatalytic spliceosome, ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62315
Entrez ID: 20641
|
Does Knockout of Galnt12 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Galnt12
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Galnt12 (polypeptide N-acetylgalactosaminyltransferase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein O-linked glycosylation, protein O-linked glycosylation via N-acetyl-galactosamine, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, molecular_function, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism of proteins, Mucin type O-glycan biosynthesis - Mus musculus (mouse), O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification
UniProt: Q8BGT9
Entrez ID: 230145
|
Does Knockout of Tgm3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Tgm3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tgm3 (transglutaminase 3, E polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epidermis development, hair cell differentiation, keratinization, keratinocyte differentiation, peptide cross-linking, skin development; MF: acyltransferase activity, calcium ion binding, catalytic activity, metal ion binding, protein-glutamine gamma-glutamyltransferase activity, structural molecule activity, transferase activity; CC: cornified envelope, cytoplasm, extracellular matrix, extrinsic component of cytoplasmic side of plasma membrane, protein-containing complex
Pathways:
UniProt: Q08189
Entrez ID: 21818
|
Does Knockout of Vmn1r68 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Vmn1r68
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r68 (vomeronasal 1 receptor 68)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: A0A494BAG0, E9Q0V3
Entrez ID: 628580
|
Does Knockout of Atg16l1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Atg16l1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atg16l1 (autophagy related 16 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, axonal transport, corpus callosum development, defense response to virus, dendrite arborization, hippocampus development, macroautophagy, microautophagy, negative regulation of dendrite extension, negative stranded viral RNA replication, positive regulation of autophagy, protein localization to phagophore assembly site, protein transport, xenophagy; MF: GTPase binding, identical protein binding, protein binding, protein-membrane adaptor activity; CC: Atg12-Atg5-Atg16 complex, autophagosome, autophagosome membrane, axon, axoneme, cytoplasm, cytosol, endolysosome membrane, endosome, endosome membrane, glutamatergic synapse, lysosomal membrane, lysosome, membrane, phagophore assembly site membrane, sperm midpiece, synapse, vacuole-isolation membrane contact site
Pathways: Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q8C0J2
Entrez ID: 77040
|
Does Knockout of Asb10 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Asb10
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Asb10 (ankyrin repeat and SOCS box-containing 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, intracellular signal transduction, protein ubiquitination; CC: cytoplasm, cytosol, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q91ZT7
Entrez ID: 117590
|
Does Knockout of Ube2l3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ube2l3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ube2l3 (ubiquitin-conjugating enzyme E2L 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell cycle phase transition, cell population proliferation, cellular response to glucocorticoid stimulus, cellular response to steroid hormone stimulus, positive regulation of DNA-templated transcription, positive regulation of protein ubiquitination, protein K11-linked ubiquitination, protein polyubiquitination, protein ubiquitination, proteolysis involved in protein catabolic process, regulation of DNA-templated transcription, ubiquitin-dependent protein catabolic process; MF: ATP binding, nucleotide binding, protein binding, transcription coactivator activity, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin protein ligase binding, ubiquitin-like protein transferase activity, ubiquitin-protein transferase activator activity, ubiquitin-protein transferase activity; CC: cytoplasm, nucleus, presynapse
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Autophagy, Class I MHC mediated antigen processing & presentation, Death Receptor Signaling, E3 ubiquitin ligases ubiquitinate target proteins, Immune System, Macroautophagy, Metabolism of proteins, Mitophagy, PINK1-PRKN Mediated Mitophagy, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Programmed Cell Death, Protein ubiquitination, RIPK1-mediated regulated necrosis, Regulated Necrosis, Regulation of TNFR1 signaling, Regulation of necroptotic cell death, Selective autophagy, Signal Transduction, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, TNF signaling, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P68037
Entrez ID: 22195
|
Does Knockout of Lekr1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Lekr1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lekr1 (leucine, glutamate and lysine rich 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, molecular_function
Pathways:
UniProt: A0A571BF98, B2RVN1, Q3UVB4
Entrez ID: 624866
|
Does Knockout of Adamtsl1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Adamtsl1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adamtsl1 (ADAMTS-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular matrix, extracellular region
Pathways: Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8BLI0
Entrez ID: 77739
|
Does Knockout of Il18rap in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Il18rap
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Il18rap (interleukin 18 receptor accessory protein)
Type: protein-coding
Summary: Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial infection. This gene encodes a member of the interleukin-1 receptor family. The encoded protein is an accessory subunit of the receptor for interleukin-18 and mediates signaling through this cytokine. Mice lacking this gene exhibit a defective cell-mediated immune response. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: adaptive immune response, cell population proliferation, cellular response to cytokine stimulus, cellular response to hydrogen peroxide, cellular response to interleukin-18, immune system process, inflammatory response, interleukin-18-mediated signaling pathway, neutrophil activation, positive regulation of NF-kappaB transcription factor activity, positive regulation of natural killer cell mediated cytotoxicity, signal transduction; MF: NAD+ nucleosidase activity, cyclic ADP-ribose generating, coreceptor activity, hydrolase activity, interleukin-1 receptor activity, interleukin-18 receptor activity; CC: cell surface, interleukin-18 receptor complex, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-1 family signaling, Interleukin-18 signaling, Signaling by Interleukins, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q9Z2B1
Entrez ID: 16174
|
Does Knockout of Csdc2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Csdc2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Csdc2 (cold shock domain containing C2, RNA binding)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA processing, regulation of mRNA stability; MF: RNA binding, mRNA 3'-UTR binding, nucleic acid binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q91YQ3
Entrez ID: 105859
|
Does Knockout of Sobp in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Sobp
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Sobp (sine oculis binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, cochlea development, cognition, inner ear morphogenesis, locomotory behavior, sensory perception of sound; MF: SUMO polymer binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q0P5V2
Entrez ID: 109205
|
Does Knockout of Pabpc1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Pabpc1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pabpc1 (poly(A) binding protein, cytoplasmic 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CRD-mediated mRNA stabilization, RNA splicing, mRNA processing, negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of cytoplasmic translation, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, regulatory ncRNA-mediated gene silencing; MF: RNA binding, mRNA 3'-UTR binding, mRNA binding, nucleic acid binding, poly(A) binding, poly(U) RNA binding, protein binding; CC: catalytic step 2 spliceosome, cell leading edge, cell projection, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, dendrite, lamellipodium, mCRD-mediated mRNA stability complex, nucleus, protein-containing complex, ribonucleoprotein complex, spliceosomal complex, synapse
Pathways: AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Eukaryotic Translation Initiation, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Translation, Translation initiation complex formation, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: P29341
Entrez ID: 18458
|
Does Knockout of Chfr in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Chfr
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Chfr (checkpoint with forkhead and ring finger domains)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, meiotic spindle checkpoint signaling, mitotic G2/M transition checkpoint, mitotic cell cycle, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein ubiquitination, protein destabilization, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, nucleotide binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: PML body, nucleus
Pathways:
UniProt: Q810L3
Entrez ID: 231600
|
Does Knockout of Dcaf7 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Dcaf7
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Dcaf7 (DDB1 and CUL4 associated factor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Cul4-RING E3 ubiquitin ligase complex, cytoplasm, cytosol, nuclear body, nuclear matrix, nucleoplasm, nucleus, protein-containing complex
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: P61963
Entrez ID: 71833
|
Does Knockout of Tbx4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Tbx4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tbx4 (T-box 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell fate specification, developmental process, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, embryonic lung development, limb morphogenesis, lung development, morphogenesis of an epithelium, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal system morphogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding; CC: chromatin, nucleus
Pathways:
UniProt: P70325
Entrez ID: 21387
|
Does Knockout of Samt4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Samt4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Samt4 (spermatogenesis associated multipass transmembrane protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicellular tight junction assembly, cell adhesion; MF: molecular_function, structural molecule activity; CC: anchoring junction, bicellular tight junction, membrane, plasma membrane
Pathways:
UniProt: Q9D4X6
Entrez ID: 75185
|
Does Knockout of Crem in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Crem
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Crem (cAMP responsive element modulator)
Type: protein-coding
Summary: This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). Different protein isoforms encoded by this gene may function as either activators or repressors of transcription. Activity of this gene is important in multiple developmental processes, including spermatogenesis. Mutation of this gene causes male infertility. Alternative splicing and promoter usage result in multiple transcript variants for this gene. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: cAMP/PKA signal transduction, circadian regulation of gene expression, circadian rhythm, glycosphingolipid metabolic process, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to cAMP, rhythmic process, spermatogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: ATF4-CREB1 transcription factor complex, cytoplasm, membrane, nucleus, transcription regulator complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse)
UniProt: P27699
Entrez ID: 12916
|
Does Knockout of Mob3c in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Mob3c
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Mob3c (MOB kinase activator 3C)
Type: protein-coding
Summary: Predicted to enable protein kinase activator activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB3C (MOB kinase activator 3C). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: metal ion binding, protein kinase activator activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8BJG4
Entrez ID: 100465
|
Does Knockout of Ddx42 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ddx42
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ddx42 (DEAD box helicase 42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: U2-type prespliceosome assembly, intracellular protein localization, regulation of apoptotic process; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: U2-type prespliceosome, cytoplasm, cytosol, nuclear speck, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q810A7
Entrez ID: 72047
|
Does Knockout of Cep78 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Cep78
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cep78 (centrosomal protein 78)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium organization, flagellated sperm motility, negative regulation of protein ubiquitination, protein localization to centrosome, protein localization to cilium; CC: cell projection, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q6IRU7
Entrez ID: 208518
|
Does Knockout of Card11 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Card11
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Card11 (caspase recruitment domain family, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, B cell proliferation, T cell activation, T cell costimulation, TORC1 signaling, canonical NF-kappaB signal transduction, homeostasis of number of cells, immune system process, lymphocyte activation, positive regulation of B cell proliferation, positive regulation of CD4-positive, alpha-beta T cell proliferation, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell activation, positive regulation of T cell receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of interleukin-2 production, protein homooligomerization, regulation of B cell differentiation, regulation of T cell differentiation, regulation of apoptotic process, regulation of immune response, signal transduction, thymic T cell selection; MF: CARD domain binding, protein binding; CC: CBM complex, cytoplasm, immunological synapse, membrane, membrane raft, plasma membrane
Pathways: Activation of NF-kappaB in B cells, Adaptive Immune System, B cell receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Immune System, Innate Immune System, NF-kappa B signaling pathway - Mus musculus (mouse), Signaling by the B Cell Receptor (BCR), T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling
UniProt: Q8CIS0
Entrez ID: 108723
|
Does Knockout of Ndufaf3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ndufaf3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ndufaf3 (NADH:ubiquinone oxidoreductase complex assembly factor 3)
Type: protein-coding
Summary: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 18. Orthologous to human NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleus
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9JKL4
Entrez ID: 66706
|
Does Knockout of Ubald1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Ubald1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ubald1 (UBA-like domain containing 1)
Type: protein-coding
Summary: Is expressed in central nervous system; embryo; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human UBALD1 (UBA like domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q6P3B2
Entrez ID: 207740
|
Does Knockout of Eras in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Eras
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Eras (ES cell-expressed Ras)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, signal transduction; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q7TN89
Entrez ID: 353283
|
Does Knockout of Tdpoz4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Tdpoz4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tdpoz4 (TD and POZ domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein catabolic process, protein polyubiquitination, regulation of proteolysis; MF: identical protein binding, molecular function inhibitor activity, ubiquitin protein ligase binding; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, nucleus
Pathways: Hedgehog signaling pathway - Mus musculus (mouse)
UniProt: Q6YCH2
Entrez ID: 399675
|
Does Knockout of Nle1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Nle1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Nle1 (notchless homolog 1)
Type: protein-coding
Summary: Acts upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and positive regulation of canonical Wnt signaling pathway. Located in nucleolus. Is expressed in several structures, including 2-cell stage embryo; gonad; hemolymphoid system gland; inner cell mass; and liver. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Notch signaling pathway, hematopoietic stem cell homeostasis, inner cell mass cell differentiation, kidney development, negative regulation of mitotic cell cycle, positive regulation of canonical Wnt signaling pathway, regulation of Notch signaling pathway, ribosomal large subunit biogenesis, skeletal system morphogenesis, somitogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8VEJ4
Entrez ID: 217011
|
Does Knockout of Pcna in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,536
|
Knockout
|
Pcna
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Pcna (proliferating cell nuclear antigen)
Type: protein-coding
Summary: Enables enzyme binding activity. Involved in mitotic telomere maintenance via semi-conservative replication and replication fork processing. Acts upstream of or within base-excision repair, gap-filling; cellular response to xenobiotic stimulus; and negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus; nuclear lamina; and replication fork. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including brain; genitourinary system; jaw; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in ataxia-telangiectasia-like disorder-2. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, base-excision repair, gap-filling, cellular response to UV, cellular response to hydrogen peroxide, cellular response to xenobiotic stimulus, chromatin organization, epithelial cell differentiation, estrous cycle, heart development, leading strand elongation, liver regeneration, mismatch repair, mitotic telomere maintenance via semi-conservative replication, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regulation of DNA replication, positive regulation of deoxyribonuclease activity, regulation of DNA replication, replication fork processing, response to L-glutamate, response to cadmium ion, response to dexamethasone, response to estradiol, response to lipid, response to oxidative stress, translesion synthesis; MF: DNA binding, DNA polymerase binding, DNA polymerase processivity factor activity, MutLalpha complex binding, chromatin binding, damaged DNA binding, dinucleotide insertion or deletion binding, enzyme binding, histone acetyltransferase binding, identical protein binding, nuclear estrogen receptor binding, protein binding, protein-containing complex binding, purine-specific mismatch base pair DNA N-glycosylase activity, receptor tyrosine kinase binding; CC: PCNA complex, PCNA-p21 complex, centrosome, chromatin, cyclin-dependent protein kinase holoenzyme complex, male germ cell nucleus, nuclear body, nuclear lamina, nuclear replication fork, nucleoplasm, nucleus, replication fork
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatitis B - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Metabolism of proteins, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Post-translational protein modification, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Protein ubiquitination, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Synthesis of DNA, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Tight junction - Mus musculus (mouse), Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P17918
Entrez ID: 18538
|
Does Knockout of Jpt1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Jpt1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Jpt1 (Jupiter microtubule associated homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, intercellular bridge, microtubule cytoskeleton, nucleoplasm, nucleus
Pathways:
UniProt: P97825
Entrez ID: 15374
|
Does Knockout of Idh1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Idh1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Idh1 (isocitrate dehydrogenase 1 (NADP+), soluble)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate metabolic process, NADP+ metabolic process, NADPH regeneration, female gonad development, glutathione metabolic process, glyoxylate cycle, isocitrate metabolic process, regulation of phospholipid biosynthetic process, regulation of phospholipid catabolic process, response to oxidative stress, response to steroid hormone, tricarboxylic acid cycle; MF: NAD binding, NADP binding, identical protein binding, isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein homodimerization activity; CC: cytoplasm, cytosol, mitochondrion, peroxisomal matrix, peroxisome
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Glutathione metabolism - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, NADPH regeneration, Neutrophil degranulation, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Protein localization
UniProt: O88844
Entrez ID: 15926
|
Does Knockout of Gm5591 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gm5591
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gm5591 (predicted gene 5591)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8CDK1
Entrez ID: 434171
|
Does Knockout of Fstl3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Fstl3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fstl3 (follistatin-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, hematopoietic progenitor cell differentiation, negative regulation of BMP signaling pathway, negative regulation of activin receptor signaling pathway, negative regulation of osteoclast differentiation, negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway, ossification, positive regulation of cell-cell adhesion, positive regulation of transcription by RNA polymerase II, regulation of BMP signaling pathway, regulation of transcription by RNA polymerase II; MF: activin binding, fibronectin binding; CC: extracellular region, extracellular space, neuron projection terminus, nucleoplasm, nucleus, secretory granule
Pathways: Antagonism of Activin by Follistatin, Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Signal Transduction, Signaling by Activin, Signaling by TGFB family members
UniProt: Q9EQC7
Entrez ID: 83554
|
Does Knockout of Tas1r3 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Tas1r3
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Tas1r3 (taste receptor, type 1, member 3)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor activity and taste receptor activity. Predicted to contribute to sweet taste receptor activity. Acts upstream of or within sensory perception of sweet taste. Predicted to be located in Golgi apparatus. Predicted to be part of sweet taste receptor complex. Predicted to be active in plasma membrane. Is expressed in circumvallate papillae and tongue anterior part. Orthologous to human TAS1R3 (taste 1 receptor member 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of sweet taste, sensory perception of sweet taste, sensory perception of taste, sensory perception of umami taste, signal transduction; MF: G protein-coupled receptor activity, protein binding, sweet taste receptor activity, taste receptor activity, transmembrane signaling receptor activity; CC: Golgi apparatus, membrane, plasma membrane, sweet taste receptor complex
Pathways: Carbohydrate digestion and absorption - Mus musculus (mouse), Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse)
UniProt: Q925D8
Entrez ID: 83771
|
Does Knockout of Vezf1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Vezf1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Vezf1 (vascular endothelial zinc finger 1)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within angiogenesis and endothelial cell development. Located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and liver. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human VEZF1 (vascular endothelial zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: angiogenesis, endothelial cell development, positive regulation of DNA-templated transcription, positive regulation of endothelial cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q5SXC3, Q5SXC4
Entrez ID: 22344
|
Does Knockout of Rps6kb1 in Melanoma Cell Line causally result in tumorigenicity?
| 1
| 615
|
Knockout
|
Rps6kb1
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Rps6kb1 (ribosomal protein S6 kinase, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, TOR signaling, TORC1 signaling, TORC2 signaling, apoptotic process, autophagosome assembly, behavioral fear response, cellular response to dexamethasone stimulus, cellular response to growth factor stimulus, cellular response to hormone stimulus, cellular response to insulin stimulus, cellular response to nutrient, cellular response to nutrient levels, cellular response to type II interferon, cytoplasmic translation, germ cell development, insulin receptor signaling pathway, long-chain fatty acid import into cell, modulation of chemical synaptic transmission, negative regulation of TORC1 signaling, negative regulation of TORC2 signaling, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of insulin receptor signaling pathway, peptidyl-serine phosphorylation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of mitotic cell cycle, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of skeletal muscle tissue growth, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of translation, positive regulation of translational initiation, regulation of D-glucose import, regulation of translation, response to glucocorticoid, response to insulin, response to ketone, response to nutrient levels, response to other organism, response to tumor necrosis factor, signal transduction, ubiquitin-dependent protein catabolic process; MF: ATP binding, PDZ domain binding, identical protein binding, kinase activity, nucleotide binding, peptide binding, protein binding, protein kinase activity, protein phosphatase 2A binding, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, ribosomal protein S6 kinase activity, transferase activity; CC: cell surface, cytoplasm, glutamatergic synapse, membrane, mitochondrial outer membrane, mitochondrion, neuron projection, nucleoplasm, nucleus, perinuclear region of cytoplasm, postsynapse, synapse
Pathways: AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MTOR signalling, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Signal Transduction, TGF-beta signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q8BSK8
Entrez ID: 72508
|
Does Knockout of Sh3rf2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Sh3rf2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sh3rf2 (SH3 domain containing ring finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of JNK cascade, negative regulation of apoptotic process, negative regulation of protein ubiquitination, positive regulation of JNK cascade, positive regulation of cell migration, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein autoubiquitination, protein ubiquitination, regulation of JNK cascade; MF: metal ion binding, phosphatase binding, protein phosphatase 1 binding, protein phosphatase inhibitor activity, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q8BZT2
Entrez ID: 269016
|
Does Knockout of Dkc1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Dkc1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dkc1 (dyskeratosis congenita 1, dyskerin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, RNA processing, box H/ACA sno(s)RNA 3'-end processing, box H/ACA sno(s)RNA metabolic process, enzyme-directed rRNA pseudouridine synthesis, mRNA pseudouridine synthesis, positive regulation of cell population proliferation, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, pseudouridine synthesis, rRNA processing, rRNA pseudouridine synthesis, regulation of telomerase RNA localization to Cajal body, ribosome biogenesis, scaRNA localization to Cajal body, snRNA pseudouridine synthesis, snoRNA guided rRNA pseudouridine synthesis, telomerase RNA stabilization, telomerase holoenzyme complex assembly, telomere maintenance via telomerase; MF: RNA binding, box H/ACA snoRNA binding, isomerase activity, protein binding, pseudouridine synthase activity, telomerase RNA binding, telomerase activity; CC: Cajal body, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, fibrillar center, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q9ESX5
Entrez ID: 245474
|
Does Knockout of H2-Q7 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
H2-Q7
|
cell cycle progression
|
breast epithelium
|
Gene: H2-Q7 (histocompatibility 2, Q region locus 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, antigen processing and presentation of peptide antigen via MHC class I, cellular response to type II interferon, embryo implantation, immune response, immune system process, positive regulation of T cell mediated cytotoxicity; MF: 14-3-3 protein binding, CD8 receptor binding, MHC class I protein binding, T cell receptor binding, TAP binding, TAP complex binding, TAP1 binding, TAP2 binding, beta-2-microglobulin binding, identical protein binding, natural killer cell lectin-like receptor binding, peptide antigen binding, peptide binding, protein homodimerization activity, protein-containing complex binding, protein-folding chaperone binding, receptor ligand activity, signaling receptor binding; CC: Golgi apparatus, Golgi medial cisterna, Golgi membrane, MHC class I peptide loading complex, MHC class I protein complex, MHC class Ib protein complex, cell surface, cis-Golgi network membrane, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum exit site, external side of plasma membrane, extracellular space, lumenal side of endoplasmic reticulum membrane, lysosomal membrane, membrane, phagocytic vesicle membrane, plasma membrane
Pathways: Adaptive Immune System, Allograft rejection - Mus musculus (mouse), Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, DAP12 interactions, ER-Phagosome pathway, Endocytosis - Mus musculus (mouse), Endosomal/Vacuolar pathway, Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Neutrophil degranulation, Phagosome - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: P14429
Entrez ID: 15018
|
Does Knockout of Axin2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Axin2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Axin2 (axin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, aortic valve morphogenesis, bone mineralization, canonical Wnt signaling pathway, cell development, cellular response to dexamethasone stimulus, chondrocyte differentiation involved in endochondral bone morphogenesis, dorsal/ventral axis specification, intracellular protein localization, intramembranous ossification, mRNA stabilization, maintenance of DNA repeat elements, mitral valve morphogenesis, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cell population proliferation, negative regulation of osteoblast differentiation, negative regulation of osteoblast proliferation, odontogenesis, positive regulation of epithelial to mesenchymal transition, positive regulation of fat cell differentiation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of Wnt signaling pathway, regulation of centromeric sister chromatid cohesion, regulation of chondrocyte development, regulation of extracellular matrix organization, regulation of mismatch repair, response to steroid hormone, secondary heart field specification, somitogenesis, stem cell proliferation; MF: I-SMAD binding, beta-catenin binding, enzyme binding, molecular adaptor activity, protein binding, protein kinase binding, ubiquitin protein ligase binding; CC: beta-catenin destruction complex, centrosome, cytoplasm, nucleus, plasma membrane, protein-containing complex
Pathways: Alzheimer disease - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Degradation of AXIN, Deubiquitination, Endometrial cancer - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Metabolism of proteins, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TCF dependent signaling in response to WNT, Ub-specific processing proteases, Wnt signaling pathway - Mus musculus (mouse)
UniProt: O88566
Entrez ID: 12006
|
Does Knockout of Tmcc3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Tmcc3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tmcc3 (transmembrane and coiled coil domains 3)
Type: protein-coding
Summary: Predicted to enable 14-3-3 protein binding activity and identical protein binding activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in endomembrane system. Is expressed in several structures, including embryo mesenchyme; epithelium; forebrain; genitourinary system; and trigeminal ganglion. Orthologous to human TMCC3 (transmembrane and coiled-coil domain family 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: 14-3-3 protein binding, identical protein binding; CC: endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q8R310
Entrez ID: 319880
|
Does Knockout of Parl in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,287
|
Knockout
|
Parl
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Parl (presenilin associated, rhomboid-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: membrane protein proteolysis, mitochondrial fusion, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of release of cytochrome c from mitochondria, protein processing, proteolysis, regulation of mitochondrion organization, regulation of mitophagy, regulation of protein targeting to mitochondrion, regulation of proteolysis, regulation of reactive oxygen species metabolic process, signal peptide processing; MF: endopeptidase activity, hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleus
Pathways: Mitochondrial calcium ion transport, Processing of SMDT1, Transport of small molecules
UniProt: Q5XJY4
Entrez ID: 381038
|
Does Knockout of Acsl4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Acsl4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Acsl4 (acyl-CoA synthetase long-chain family member 4)
Type: protein-coding
Summary: Enables long-chain fatty acid-CoA ligase activity. Involved in fatty acid derivative biosynthetic process and fatty acid metabolic process. Acts upstream of or within embryonic process involved in female pregnancy. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; limb mesenchyme; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: alpha-linolenic acid metabolic process, dendritic spine development, embryonic process involved in female pregnancy, fatty acid derivative biosynthetic process, fatty acid metabolic process, fatty acid transport, lipid biosynthetic process, lipid metabolic process, long-chain fatty acid biosynthetic process, long-chain fatty acid metabolic process, long-chain fatty-acyl-CoA biosynthetic process, long-chain fatty-acyl-CoA metabolic process, negative regulation of prostaglandin secretion, neuron differentiation, positive regulation of cell growth, positive regulation of ferroptosis, positive regulation of insulin secretion, regulation of fatty acid metabolic process, small molecule metabolic process, triglyceride biosynthetic process, unsaturated fatty acid biosynthetic process; MF: ATP binding, arachidonate-CoA ligase activity, ligase activity, long-chain fatty acid-CoA ligase activity, nucleotide binding, very long-chain fatty acid-CoA ligase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, neuronal cell body, peroxisomal membrane, peroxisome, plasma membrane
Pathways: Adipocytokine signaling pathway - Mus musculus (mouse), Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Ferroptosis - Mus musculus (mouse), Free fatty acids regulate insulin secretion, Integration of energy metabolism, Intracellular metabolism of fatty acids regulates insulin secretion, Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), Peroxisome - Mus musculus (mouse), Regulation of insulin secretion, Synthesis of very long-chain fatty acyl-CoAs, Thermogenesis - Mus musculus (mouse), fatty acid β-oxidation I, fatty acid β-oxidation II (core pathway), fatty acid activation
UniProt: Q9QUJ7
Entrez ID: 50790
|
Does Knockout of Epn1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Epn1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Epn1 (epsin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, clathrin coat assembly, embryonic organ development, endocytosis, female pregnancy, in utero embryonic development, membrane fission, negative regulation of sprouting angiogenesis, positive regulation of clathrin coat assembly; MF: clathrin adaptor activity, clathrin binding, lipid binding, molecular sequestering activity, phospholipid binding, transmembrane transporter binding; CC: Schaffer collateral - CA1 synapse, clathrin vesicle coat, clathrin-coated pit, cytoplasm, cytosol, endosome, membrane, nucleus, plasma membrane, postsynapse, postsynaptic membrane, presynaptic membrane
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, EGFR downregulation, Endocytosis - Mus musculus (mouse), Membrane Trafficking, Signal Transduction, Signaling by EGFR, Signaling by Receptor Tyrosine Kinases, Vesicle-mediated transport
UniProt: Q80VP1
Entrez ID: 13854
|
Does Knockout of Ciart in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Ciart
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ciart (circadian associated repressor of transcription)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian regulation of gene expression, locomotor rhythm, negative regulation of DNA-templated transcription, rhythmic process; MF: E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, transcription cis-regulatory region binding; CC: PML body, nucleus
Pathways:
UniProt: Q3TQ03
Entrez ID: 229599
|
Does Knockout of Il20 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Il20
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Il20 (interleukin 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hemopoiesis, immune response, positive regulation of osteoclast differentiation, signal transduction; MF: cytokine activity, interleukin-20 receptor binding, interleukin-22 receptor binding, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-20 family signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Signaling by Interleukins, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q9JKV9
Entrez ID: 58181
|
Does Knockout of Fxn in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Fxn
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fxn (frataxin)
Type: protein-coding
Summary: Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; ferroxidase activity; and iron ion binding activity. Involved in [4Fe-4S] cluster assembly. Acts upstream of or within several processes, including adult walking behavior; muscle cell cellular homeostasis; and negative regulation of organ growth. Located in mitochondrion. Part of mitochondrial [2Fe-2S] assembly complex. Is expressed in several structures, including brain; cartilage condensation; heart; hemolymphoid system; and lower jaw incisor. Used to study Friedreich ataxia. Human ortholog(s) of this gene implicated in Friedreich ataxia; Friedreich ataxia 1; glioblastoma; and type 2 diabetes mellitus. Orthologous to human FXN (frataxin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: [2Fe-2S] cluster assembly, [4Fe-4S] cluster assembly, adult walking behavior, aerobic respiration, cellular response to hydrogen peroxide, embryo development ending in birth or egg hatching, heme biosynthetic process, inorganic ion homeostasis, intracellular iron ion homeostasis, intracellular monoatomic cation homeostasis, iron import into the mitochondrion, iron ion transport, iron-sulfur cluster assembly, mitochondrion organization, monoatomic ion transport, muscle cell cellular homeostasis, negative regulation of apoptotic process, negative regulation of lipid storage, negative regulation of multicellular organism growth, negative regulation of neuron apoptotic process, negative regulation of organ growth, negative regulation of release of cytochrome c from mitochondria, oxidative phosphorylation, positive regulation of axon extension, positive regulation of mitochondrial membrane permeability, proprioception, protein autoprocessing, protein maturation, regulation of cytosolic calcium ion concentration, regulation of growth, response to iron ion; MF: 2 iron, 2 sulfur cluster binding, enzyme activator activity, enzyme binding, ferric iron binding, ferrous iron binding, ferroxidase activity, iron chaperone activity, metal ion binding, oxidoreductase activity; CC: cytoplasm, cytosol, iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Complex III assembly, Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Mitochondrial protein import, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), Protein localization, Respiratory electron transport
UniProt: O35943
Entrez ID: 14297
|
Does Knockout of Tcaim in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Tcaim
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tcaim (T cell activation inhibitor, mitochondrial)
Type: protein-coding
Summary: Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human TCAIM (T cell activation inhibitor, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: mitochondrion
Pathways:
UniProt: Q66JZ4
Entrez ID: 382117
|
Does Knockout of Zfyve26 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Zfyve26
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfyve26 (zinc finger, FYVE domain containing 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, autophagosome organization, cell division, double-strand break repair via homologous recombination, lysosome organization, mitotic cytokinesis, regulation of cytokinesis; MF: lipid binding, metal ion binding, phosphatidylinositol-3-phosphate binding, protein binding, protein kinase binding, zinc ion binding; CC: centrosome, cytoplasm, cytoskeleton, early endosome, late endosome, lysosome, midbody
Pathways:
UniProt: Q5DU37
Entrez ID: 211978
|
Does Knockout of Chmp6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,287
|
Knockout
|
Chmp6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Chmp6 (charged multivesicular body protein 6)
Type: protein-coding
Summary: Predicted to be involved in several processes, including midbody abscission; regulation of protein metabolic process; and vacuolar transport. Predicted to be located in several cellular components, including bounding membrane of organelle; kinetochore microtubule; and midbody. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in multivesicular body. Is expressed in several structures, including branchial arch; facial prominence; heart; limb bud; and neural fold. Orthologous to human CHMP6 (charged multivesicular body protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: autophagosome maturation, autophagy, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, membrane fission, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein transport, regulation of mitotic spindle assembly, regulation of protein catabolic process, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; MF: protein-containing complex binding; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, endomembrane system, endosome, endosome membrane, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, midbody, multivesicular body, multivesicular body membrane, nuclear pore, plasma membrane
Pathways: Autophagy, Cell Cycle, Cell Cycle, Mitotic, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Mus musculus (mouse), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, Sealing of the nuclear envelope (NE) by ESCRT-III, Vesicle-mediated transport
UniProt: P0C0A3
Entrez ID: 208092
|
Does Knockout of Ube2r2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Ube2r2
|
phagocytosis
|
macrophage
|
Gene: Ube2r2 (ubiquitin-conjugating enzyme E2R 2)
Type: protein-coding
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination; protein monoubiquitination; and ubiquitin-dependent protein catabolic process. Orthologous to human UBE2R2 (ubiquitin conjugating enzyme E2 R2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: protein K48-linked ubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, nucleotide binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q6ZWZ2
Entrez ID: 67615
|
Does Knockout of Ifne in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Ifne
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ifne (interferon epsilon)
Type: protein-coding
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Involved in defense response to bacterium and defense response to virus. Predicted to be active in extracellular space. Is expressed in diencephalon floor plate and midbrain floor plate. Orthologous to human IFNE (interferon epsilon). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to bacterium, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q80ZF2
Entrez ID: 230405
|
Does Knockout of Cog7 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Cog7
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Cog7 (component of oligomeric golgi complex 7)
Type: protein-coding
Summary: Predicted to be involved in several processes, including Golgi vesicle transport; protein localization to Golgi apparatus; and protein stabilization. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be part of Golgi transport complex. Is expressed in lung; metanephros; pancreas; submandibular gland; and testis. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIe. Orthologous to human COG7 (component of oligomeric golgi complex 7). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi organization, glycosylation, intracellular protein transport, protein glycosylation, protein localization to Golgi apparatus, protein stabilization, protein transport, retrograde transport, vesicle recycling within Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; CC: Golgi apparatus, Golgi membrane, Golgi transport complex, membrane, nucleolus
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q3UM29
Entrez ID: 233824
|
Does Knockout of Polr3k in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Polr3k
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Polr3k (polymerase (RNA) III (DNA directed) polypeptide K)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, defense response to virus, immune system process, innate immune response, termination of RNA polymerase III transcription, transcription by RNA polymerase III; MF: DNA-directed RNA polymerase activity, metal ion binding, nucleic acid binding, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: Q9CQZ7
Entrez ID: 67005
|
Does Knockout of Btbd8 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Btbd8
|
cell proliferation
|
Regulatory T cell
|
Gene: Btbd8 (BTB domain containing 8)
Type: protein-coding
Summary: Involved in synaptic vesicle budding from endosome and synaptic vesicle endocytosis. Is extrinsic component of synaptic vesicle membrane. Is expressed in several structures, including adrenal gland; genitourinary system; liver; nervous system; and retina. Orthologous to human BTBD8 (BTB domain containing 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: synaptic vesicle budding from endosome, synaptic vesicle endocytosis; CC: AP-2 adaptor complex, axon, cell projection, clathrin-coated vesicle, cytoplasmic vesicle, extrinsic component of synaptic vesicle membrane, neuron projection terminus, nucleoplasm, nucleus, presynapse, synapse, synaptic vesicle
Pathways:
UniProt: D3YUB6
Entrez ID: 100503185
|
Does Knockout of Pop7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Pop7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pop7 (processing of precursor 7, ribonuclease P family, (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: nucleic acid binding, ribonuclease P RNA binding, ribonuclease P activity; CC: cytoplasm, multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonuclease MRP complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9DCH2
Entrez ID: 74097
|
Does Knockout of Srsf2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Srsf2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Srsf2 (serine and arginine-rich splicing factor 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: RNA splicing, mRNA processing, regulation of alternative mRNA splicing, via spliceosome, response to vitamin E; MF: RNA binding, mRNA binding, nucleic acid binding, pre-mRNA binding, protein binding, protein kinase C binding; CC: cytosol, interchromatin granule, nuclear speck, nucleoplasm, nucleus, perichromatin fibrils, spliceosomal complex
Pathways: Gene expression (Transcription), Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q62093
Entrez ID: 20382
|
Does Knockout of Trpc6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Trpc6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Trpc6 (transient receptor potential cation channel, subfamily C, member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, cellular response to hydrogen peroxide, cellular response to hypoxia, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of dendrite morphogenesis, neuron differentiation, positive regulation of calcium ion transport, positive regulation of cytosolic calcium ion concentration, positive regulation of neuron differentiation, regulation of cytosolic calcium ion concentration, single fertilization, transmembrane transport; MF: ATPase binding, actin binding, actinin binding, calcium channel activity, clathrin binding, inositol 1,4,5 trisphosphate binding, monoatomic cation channel activity, monoatomic ion channel activity, protein binding, protein homodimerization activity, store-operated calcium channel activity; CC: cation channel complex, cytoplasm, membrane, plasma membrane, slit diaphragm
Pathways: Axon guidance - Mus musculus (mouse), Effects of PIP2 hydrolysis, Elevation of cytosolic Ca2+ levels, G alpha (q) signalling events, GPCR downstream signalling, Hemostasis, Ion channel transport, Platelet activation, signaling and aggregation, Platelet calcium homeostasis, Platelet homeostasis, Signal Transduction, Signaling by GPCR, Stimuli-sensing channels, TRP channels, Transport of small molecules, cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q61143
Entrez ID: 22068
|
Does Knockout of Wrap53 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Wrap53
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Wrap53 (WD repeat containing, antisense to Trp53)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Cajal body organization, DNA damage response, DNA repair, RNA folding, positive regulation of DNA repair, positive regulation of double-strand break repair, positive regulation of double-strand break repair via homologous recombination, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of establishment of protein localization to telomere, positive regulation of telomere maintenance via telomerase, protein localization to Cajal body, scaRNA localization to Cajal body, telomerase RNA localization to Cajal body, telomere formation via telomerase, telomere maintenance via telomerase; MF: RNA binding, RNA folding chaperone, histone binding, identical protein binding, protein carrier chaperone, protein-containing complex binding, protein-folding chaperone binding, telomerase RNA binding, ubiquitin protein ligase binding; CC: Cajal body, chromosome, chromosome, telomeric region, cytosol, nuclear body, nucleoplasm, nucleus, site of double-strand break, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q8VC51
Entrez ID: 216853
|
Does Knockout of Dennd6a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Dennd6a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Dennd6a (DENN domain containing 6A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell-cell adhesion mediated by cadherin; MF: guanyl-nucleotide exchange factor activity; CC: cytoplasm, endosome, recycling endosome
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q8BH65
Entrez ID: 211922
|
Does Knockout of Trp53i11 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Trp53i11
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trp53i11 (transformation related protein 53 inducible protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q4QQM4
Entrez ID: 277414
|
Does Knockout of Rps25 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Rps25
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rps25 (ribosomal protein S25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, rRNA processing, ribosomal small subunit biogenesis; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62852
Entrez ID: 75617
|
Does Knockout of Slitrk6 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Slitrk6
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Slitrk6 (SLIT and NTRK-like family, member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult locomotory behavior, auditory behavior, auditory receptor cell morphogenesis, axonogenesis, camera-type eye development, cochlea development, inner ear morphogenesis, innervation, lens development in camera-type eye, linear vestibuloocular reflex, multicellular organism growth, neuron projection morphogenesis, positive regulation of synapse assembly, sensory perception of sound, startle response, synapse assembly, vestibular reflex, vestibulocochlear nerve development, visual perception; CC: cell periphery, cell surface, membrane, plasma membrane
Pathways: Neuronal System, Protein-protein interactions at synapses, Receptor-type tyrosine-protein phosphatases
UniProt: Q8C110
Entrez ID: 239250
|
Does Knockout of Vps13a in Malignant Peripheral Nerve Sheath Tumor (MPNST) cancer cell causally result in cell proliferation?
| 1
| 2,182
|
Knockout
|
Vps13a
|
cell proliferation
|
Malignant Peripheral Nerve Sheath Tumor (MPNST) cancer cell
|
Gene: Vps13a (vacuolar protein sorting 13A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult locomotory behavior, autophagy, brain-derived neurotrophic factor receptor signaling pathway, cell morphogenesis, cellular response to osmotic stress, erythrocyte differentiation, exploration behavior, flagellated sperm motility, gene expression, lipid transport, locomotory behavior, long-term synaptic depression, lysosomal protein catabolic process, microglia differentiation, motor behavior, multicellular organism growth, nervous system development, neuroinflammatory response, neuromuscular process, neuromuscular process controlling balance, neuron projection arborization, protein retention in Golgi apparatus, protein secretion, protein targeting to vacuole, regulation of synaptic plasticity, response to environmental enrichment, social behavior, sperm mitochondrion organization; CC: Golgi apparatus, cytoplasmic vesicle, dense core granule, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, lipid droplet, lysosomal membrane, lysosome, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, neuron projection, neuronal cell body, neuronal dense core vesicle, neuronal dense core vesicle lumen, sperm midpiece
Pathways:
UniProt: Q5H8C4
Entrez ID: 271564
|
Does Knockout of Ncbp1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ncbp1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ncbp1 (nuclear cap binding protein subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 7-methylguanosine mRNA capping, RNA catabolic process, RNA metabolic process, RNA splicing, alternative mRNA splicing, via spliceosome, cap-dependent translational initiation, defense response to virus, histone mRNA metabolic process, mRNA 3'-end processing, mRNA export from nucleus, mRNA metabolic process, mRNA processing, mRNA splicing, via spliceosome, mRNA transcription by RNA polymerase II, mRNA transport, miRNA-mediated post-transcriptional gene silencing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of cell growth, positive regulation of mRNA 3'-end processing, positive regulation of mRNA splicing, via spliceosome, positive regulation of transcription elongation by RNA polymerase II, primary miRNA processing, regulation of mRNA processing, regulation of translation, regulation of translational initiation, regulatory ncRNA-mediated gene silencing, regulatory ncRNA-mediated post-transcriptional gene silencing, snRNA export from nucleus, spliceosomal complex assembly; MF: RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, mRNA binding, molecular adaptor activity, protein binding; CC: RNA cap binding complex, cytoplasm, cytosol, mitochondrion, nuclear cap binding complex, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), FGFR2 alternative splicing, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear RNA decay, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Termination, RNA polymerase II transcribes snRNA genes, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Receptor Tyrosine Kinases, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mRNA 3'-end processing, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q3UYV9
Entrez ID: 433702
|
Does Knockout of Znhit1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Znhit1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Znhit1 (zinc finger, HIT domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion homeostasis, chromatin organization, chromatin remodeling, heart process, hematopoietic stem cell homeostasis, intestinal stem cell homeostasis, muscle cell differentiation, negative regulation of G0 to G1 transition, negative regulation of transcription by RNA polymerase II, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of lymphoid progenitor cell differentiation, positive regulation of transcription initiation by RNA polymerase II, regulation of DNA-templated transcription, regulation of T cell proliferation, transcription initiation-coupled chromatin remodeling; MF: chromatin binding, histone binding, histone deacetylase binding, metal ion binding, nucleosome binding, protein binding, zinc ion binding; CC: Swr1 complex, nucleoplasm, nucleosome, nucleus
Pathways:
UniProt: Q8R331
Entrez ID: 70103
|
Does Knockout of Pold1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Pold1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pold1 (polymerase (DNA directed), delta 1, catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA replication proofreading, DNA synthesis involved in DNA repair, DNA-templated DNA replication, base-excision repair, gap-filling, cellular response to UV, error-free translesion synthesis, fatty acid homeostasis, nucleotide-excision repair, DNA gap filling; MF: 3'-5' exonuclease activity, 3'-5'-DNA exonuclease activity, 4 iron, 4 sulfur cluster binding, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, catalytic activity, acting on a nucleic acid, chromatin binding, damaged DNA binding, enzyme binding, exonuclease activity, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, transferase activity, zinc ion binding; CC: aggresome, chromosome, telomeric region, cytosol, delta DNA polymerase complex, nucleoplasm, nucleotide-excision repair complex, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P52431
Entrez ID: 18971
|
Does Knockout of Trp53rkb in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Trp53rkb
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Trp53rkb (transformation related protein 53 regulating kinase B)
Type: protein-coding
Summary: Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and tRNA threonylcarbamoyladenosine metabolic process. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system; forelimb bud; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: tRNA processing, tRNA threonylcarbamoyladenosine metabolic process; MF: ATP binding, catalytic activity, hydrolase activity, kinase activity, nucleotide binding, p53 binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: EKC/KEOPS complex, cytoplasm, cytosol, nucleus
Pathways:
UniProt: A2A5R0, Q543M9
Entrez ID: 76367
|
Does Knockout of Parp16 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Parp16
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Parp16 (poly (ADP-ribose) polymerase family, member 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRE1-mediated unfolded protein response, cellular response to leukemia inhibitory factor, cytoplasmic translation, endoplasmic reticulum unfolded protein response, negative regulation of cytoplasmic translation, protein auto-ADP-ribosylation, response to unfolded protein; MF: NAD+ poly-ADP-ribosyltransferase activity, NAD+-protein mono-ADP-ribosyltransferase activity, NAD+-protein-aspartate ADP-ribosyltransferase activity, NAD+-protein-glutamate ADP-ribosyltransferase activity, NAD+-protein-lysine ADP-ribosyltransferase activity, glycosyltransferase activity, kinase binding, nucleotidyltransferase activity, protein serine/threonine kinase activator activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, membrane, nuclear envelope
Pathways:
UniProt: Q7TMM8
Entrez ID: 214424
|
Does Knockout of Tyrp1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Tyrp1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tyrp1 (tyrosinase-related protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetoacetic acid metabolic process, melanin biosynthetic process, melanin biosynthetic process from tyrosine, melanin metabolic process, melanocyte differentiation, melanosome organization, pigmentation, positive regulation of melanin biosynthetic process; MF: identical protein binding, metal ion binding, monooxygenase activity, oxidoreductase activity, protein binding, protein homodimerization activity, tyrosinase activity; CC: bounding membrane of organelle, clathrin-coated endocytic vesicle membrane, cytoplasm, cytoplasmic vesicle membrane, endosome membrane, intracellular vesicle, melanosome, melanosome membrane, membrane
Pathways: Melanin biosynthesis, Melanogenesis - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Tyrosine metabolism - Mus musculus (mouse)
UniProt: P07147
Entrez ID: 22178
|
Does Knockout of Vmn2r90 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Vmn2r90
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Vmn2r90 (vomeronasal 2, receptor 90)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A338P6K0, E9PXJ8, A0A338P772, A0A338P698
Entrez ID: 626942
|
Does Knockout of Otol1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Otol1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Otol1 (otolin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: otolith mineralization, protein homooligomerization; MF: calcium ion binding, metal ion binding, protein binding; CC: collagen trimer, extracellular region
Pathways:
UniProt: Q4ZJM7
Entrez ID: 229389
|
Does Knockout of Bap1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Bap1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Bap1 (Brca1 associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell population proliferation, chromatin organization, common myeloid progenitor cell proliferation, erythrocyte differentiation, erythrocyte maturation, gene expression, granulocyte differentiation, hematopoietic stem cell homeostasis, heterochromatin formation, in utero embryonic development, leukocyte proliferation, macrophage homeostasis, mitotic cell cycle, monoubiquitinated protein deubiquitination, myeloid cell apoptotic process, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, neuron cellular homeostasis, neutrophil differentiation, nucleate erythrocyte differentiation, platelet morphogenesis, protein K48-linked deubiquitination, protein deubiquitination, proteolysis, regulation of cell cycle, regulation of cell growth, regulation of cytokine production involved in inflammatory response, regulation of gene expression, regulation of inflammatory response, thrombocyte differentiation, tissue homeostasis, ubiquitin-dependent protein catabolic process; MF: chromatin DNA binding, chromatin binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2A deubiquitinase activity, hydrolase activity, peptidase activity, protein binding; CC: PR-DUB complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, Metabolism of proteins, Post-translational protein modification, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, UCH proteinases
UniProt: Q99PU7
Entrez ID: 104416
|
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