prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Sptb in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Sptb
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sptb (spectrin beta, erythrocytic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament capping, hemopoiesis, modification of postsynaptic actin cytoskeleton, plasma membrane organization, porphyrin-containing compound biosynthetic process; MF: actin binding, actin filament binding, ankyrin binding, protein binding, structural constituent of cytoskeleton; CC: cell cortex, cell junction, cell projection, cell surface, cortical actin cytoskeleton, cortical cytoskeleton, cytoplasm, cytoskeleton, cytosol, glutamatergic synapse, membrane, plasma membrane, postsynapse, protein-containing complex, spectrin, spectrin-associated cytoskeleton
Pathways:
UniProt: E9Q397, Q3UGX2
Entrez ID: 20741
|
Does Knockout of Vmn2r18 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Vmn2r18
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmn2r18 (vomeronasal 2, receptor 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2W3Z9, A0A8V5KY92, A0A3B2WCD9, A0A3B2WB67, A0A3B2WDC6
Entrez ID: 632671
|
Does Knockout of Ntm in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ntm
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ntm (neurotrimin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, negative regulation of glial cell proliferation, negative regulation of neuron projection development, positive regulation of Schwann cell migration, positive regulation of neuron projection development; CC: axon, cell surface, excitatory synapse, extracellular space, hippocampal mossy fiber to CA3 synapse, membrane, perinuclear region of cytoplasm, plasma membrane, postsynaptic density membrane, presynaptic active zone membrane, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q99PJ0
Entrez ID: 235106
|
Does Knockout of Hspd1 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,545
|
Knockout
|
Hspd1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Hspd1 (heat shock protein 1 (chaperonin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell proliferation, MyD88-dependent toll-like receptor signaling pathway, T cell activation, adhesion of symbiont to host, apoptotic mitochondrial changes, biological process involved in interaction with symbiont, cellular response to interleukin-7, isotype switching to IgG isotypes, mitochondrial unfolded protein response, negative regulation of apoptotic process, negative regulation of execution phase of apoptosis, positive regulation of T cell activation, positive regulation of T cell mediated immune response to tumor cell, positive regulation of cytokine production, positive regulation of execution phase of apoptosis, positive regulation of interferon-alpha production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of macrophage activation, positive regulation of type II interferon production, protein folding, protein import into mitochondrial intermembrane space, protein refolding, protein stabilization, response to cold, response to unfolded protein; MF: ATP binding, ATP-dependent protein folding chaperone, apolipoprotein A-I binding, apolipoprotein binding, cysteine-type endopeptidase activator activity, double-stranded RNA binding, enzyme binding, high-density lipoprotein particle binding, isomerase activity, lipopolysaccharide binding, modification-dependent protein binding, nucleotide binding, p53 binding, protein-containing complex binding, protein-folding chaperone binding, ubiquitin protein ligase binding; CC: Golgi cisterna, cell surface, clathrin-coated pit, coated vesicle, cytoplasm, cytosol, early endosome, extracellular exosome, extracellular space, lipopolysaccharide receptor complex, membrane, migrasome, mitochondrial crista, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, myelin sheath, peroxisomal matrix, plasma membrane, protein-containing complex, secretory granule, sperm midpiece, sperm plasma membrane, zymogen granule
Pathways: Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial protein import, Protein localization, RNA degradation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse)
UniProt: P63038
Entrez ID: 15510
|
Does Knockout of Gtf2a1l in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Gtf2a1l
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gtf2a1l (general transcription factor IIA, 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cognition, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, protein binding; CC: cytoplasm, male germ cell nucleus, nucleus, transcription factor TFIIA complex
Pathways: Basal transcription factors - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q8R4I4
Entrez ID: 71828
|
Does Knockout of Zfp648 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Zfp648
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp648 (zinc finger protein 648)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to human ZNF648 (zinc finger protein 648). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways:
UniProt: D3Z0W3
Entrez ID: 100503355
|
Does Knockout of Vmn2r59 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Vmn2r59
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vmn2r59 (vomeronasal 2, receptor 59)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2WCU2, E9PUT5, A0A3B2WCE4
Entrez ID: 628444
|
Does Knockout of Htr3a in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Htr3a
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Htr3a (5-hydroxytryptamine (serotonin) receptor 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chemical synaptic transmission, excitatory postsynaptic potential, inorganic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of membrane potential, regulation of postsynaptic membrane potential, regulation of presynaptic membrane potential, serotonin receptor signaling pathway, serotonin-gated cation-selective signaling pathway; MF: excitatory extracellular ligand-gated monoatomic ion channel activity, extracellular ligand-gated monoatomic ion channel activity, identical protein binding, ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, monoatomic ion channel activity, serotonin binding, serotonin-gated monoatomic cation channel activity, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: axon, cleavage furrow, glutamatergic synapse, membrane, neuron projection, neuronal cell body, plasma membrane, postsynaptic membrane, presynaptic membrane, serotonin-activated cation-selective channel complex, synapse, transmembrane transporter complex
Pathways: Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Serotonergic synapse - Mus musculus (mouse), Taste transduction - Mus musculus (mouse), Transmission across Chemical Synapses
UniProt: P23979
Entrez ID: 15561
|
Does Knockout of Gnl2 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Gnl2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Gnl2 (guanine nucleotide binding protein nucleolar 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, nucleotide binding; CC: nucleolus, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q99LH1
Entrez ID: 230737
|
Does Knockout of Cyp2d26 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Cyp2d26
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cyp2d26 (cytochrome P450, family 2, subfamily d, polypeptide 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, response to xenobiotic stimulus, xenobiotic metabolic process; MF: anandamide 11,12 epoxidase activity, anandamide 14,15 epoxidase activity, anandamide 8,9 epoxidase activity, aromatase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, mitochondrion
Pathways: Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q8CIM7
Entrez ID: 76279
|
Does Knockout of Cyth3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Cyth3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cyth3 (cytohesin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi vesicle transport, establishment of epithelial cell polarity, positive regulation of cell adhesion, regulation of ARF protein signal transduction; MF: guanyl-nucleotide exchange factor activity, lipid binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding; CC: adherens junction, anchoring junction, bicellular tight junction, cytoplasm, cytosol, membrane, nucleoplasm, plasma membrane, ruffle
Pathways: Endocytosis - Mus musculus (mouse), Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Phospholipase D signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Vesicle-mediated transport
UniProt: O08967
Entrez ID: 19159
|
Does Knockout of Klrd1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Klrd1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Klrd1 (killer cell lectin-like receptor, subfamily D, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, immune system process, innate immune response, natural killer cell mediated immunity, negative regulation of T cell mediated cytotoxicity, negative regulation of natural killer cell mediated cytotoxicity, positive regulation of natural killer cell mediated cytotoxicity, regulation of natural killer cell activation, stimulatory C-type lectin receptor signaling pathway; MF: HLA-E specific inhibitory MHC class Ib receptor activity, MHC class I protein complex binding, MHC class Ib protein binding, via antigen binding groove, carbohydrate binding, protein antigen binding, transmembrane signaling receptor activity; CC: external side of plasma membrane, membrane, plasma membrane, receptor complex
Pathways: Antigen processing and presentation - Mus musculus (mouse), DAP12 interactions, DAP12 signaling, Graft-versus-host disease - Mus musculus (mouse), Immune System, Innate Immune System, Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: O54707
Entrez ID: 16643
|
Does Knockout of Tle4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Tle4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tle4 (transducin-like enhancer of split 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, cellular response to leukemia inhibitory factor, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA-binding transcription factor binding, chromatin binding, protein binding, transcription corepressor activity; CC: beta-catenin-TCF complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Formation of the beta-catenin:TCF transactivating complex, Notch signaling pathway - Mus musculus (mouse), Repression of WNT target genes, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q62441
Entrez ID: 21888
|
Does Knockout of Spata31d1a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Spata31d1a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Spata31d1a (spermatogenesis associated 31 subfamily D, member 1A)
Type: protein-coding
Summary: Orthologous to several human genes including SPATA31D1 (SPATA31 subfamily D member 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8CDS1, E9QA35, Q9CVY6, A0A286YCE9
Entrez ID: 72219
|
Does Knockout of Gse1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gse1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gse1 (genetic suppressor element 1, coiled-coil protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, gene expression, in utero embryonic development, placenta development
Pathways:
UniProt: Q3U3C9
Entrez ID: 382034
|
Does Knockout of Prelid3b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Prelid3b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Prelid3b (PRELI domain containing 3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermembrane lipid transfer, phospholipid transport; CC: mitochondrial intermembrane space, mitochondrion
Pathways:
UniProt: Q9CYY7
Entrez ID: 66390
|
Does Knockout of Psmc3ip in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Psmc3ip
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Psmc3ip (proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA recombination, androgen receptor signaling pathway, estrogen receptor signaling pathway, homologous chromosome pairing at meiosis, meiotic cell cycle, meiotic joint molecule formation, meiotic strand invasion involved in reciprocal meiotic recombination, positive regulation of DNA-templated transcription, positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway, progesterone receptor signaling pathway, reciprocal meiotic recombination, thyroid hormone receptor signaling pathway; MF: DNA binding, DNA binding domain binding, double-stranded DNA binding, identical protein binding, nuclear estrogen receptor binding, nuclear glucocorticoid receptor binding, nuclear retinoid X receptor binding, nuclear thyroid hormone receptor binding, recombinase activator activity, transcription coactivator activity; CC: DNA recombinase auxiliary factor complex, condensed nuclear chromosome, nucleoplasm, nucleus
Pathways:
UniProt: O35047
Entrez ID: 19183
|
Does Knockout of Dot1l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Dot1l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dot1l (DOT1 like histone lysine methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA repair, chromatin organization, gene expression, heterochromatin formation, methylation, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, regulation of cell cycle, regulation of receptor signaling pathway via JAK-STAT, sodium ion transport, subtelomeric heterochromatin formation; MF: RNA polymerase II-specific DNA-binding transcription factor binding, histone H3 methyltransferase activity, histone H3K79 methyltransferase activity, histone H3K79 trimethyltransferase activity, histone methyltransferase activity, methyltransferase activity, nucleic acid binding, transcription coactivator activity, transferase activity; CC: chromosome, telomeric region, cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Lysine degradation - Mus musculus (mouse), PKMTs methylate histone lysines, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: E9Q6I8, Q6XZL8, F6S070, F7CVL0, F6SJX8
Entrez ID: 208266
|
Does Knockout of Cpa1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Cpa1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cpa1 (carboxypeptidase A1, pancreatic)
Type: protein-coding
Summary: This gene encodes carboxypeptidase A, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme. This gene is expressed in pancreas, the encoded protein is a major component of digestive enzymes secreted by pancreas and plays an important role in the process of digestion. This gene is located in a cluster of related carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: proteolysis, proteolysis involved in protein catabolic process, response to cadmium ion; MF: carboxypeptidase activity, exopeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular region, extracellular space
Pathways: Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q7TPZ8
Entrez ID: 109697
|
Does Knockout of Ntpcr in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Ntpcr
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ntpcr (nucleoside-triphosphatase, cancer-related)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, CTPase activity, GTPase activity, hydrolase activity, molecular_function, nucleotide binding, ribonucleoside triphosphate phosphatase activity
Pathways: Purine metabolism - Mus musculus (mouse), Thiamine metabolism - Mus musculus (mouse)
UniProt: Q9CQA9
Entrez ID: 66566
|
Does Knockout of Slfn1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Slfn1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Slfn1 (schlafen 1)
Type: protein-coding
Summary: Predicted to enable RNA nuclease activity and ribosome binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of T cell proliferation; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; oviduct; and spleen. Orthologous to human SLFN12 (schlafen family member 12). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: adaptive immune response, apoptotic signaling pathway, immune system process, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell proliferation, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, rRNA catabolic process, regulation of cell cycle; MF: RNA nuclease activity, protein binding, ribosome binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q9Z0I7
Entrez ID: 20555
|
Does Knockout of Zfp93 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Zfp93
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp93 (zinc finger protein 93)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, zinc ion binding
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q61116
Entrez ID: 22755
|
Does Knockout of Ttll12 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ttll12
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ttll12 (tubulin tyrosine ligase-like family, member 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, immune system process, innate immune response, negative regulation of type I interferon-mediated signaling pathway, regulation of mitotic cell cycle; MF: ATP binding, acid-amino acid ligase activity, catalytic activity, acting on a protein, histone H4K20me2 reader activity, nucleotide binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, midbody, nucleus, plasma membrane, spindle
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: Q3UDE2
Entrez ID: 223723
|
Does Knockout of Timeless in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Timeless
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Timeless (timeless circadian clock 1)
Type: protein-coding
Summary: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication checkpoint signaling, branching involved in ureteric bud morphogenesis, branching morphogenesis of an epithelial tube, cell cycle phase transition, cell division, cellular response to bleomycin, cellular response to cisplatin, cellular response to hydroxyurea, circadian rhythm, kidney development, lung development, morphogenesis of an epithelium, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of circadian rhythm, positive regulation of double-strand break repair, positive regulation of double-strand break repair via homologous recombination, regulation of circadian rhythm, replication fork arrest, replication fork processing, rhythmic process; MF: DNA binding, enzyme activator activity, identical protein binding, protein binding; CC: chromatin, chromosome, nucleoplasm, nucleus, replication fork protection complex, site of double-strand break
Pathways: DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends
UniProt: Q9R1X4
Entrez ID: 21853
|
Does Knockout of Siae in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Siae
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Siae (sialic acid acetylesterase)
Type: protein-coding
Summary: Predicted to enable sialate O-acetylesterase activity. Predicted to be involved in carbohydrate metabolic process and regulation of immune system process. Located in lysosome. Is expressed in several structures, including abdominal fat pad; central nervous system; genitourinary system; immune system; and yolk sac. Human ortholog(s) of this gene implicated in autoimmune disease. Orthologous to human SIAE (sialic acid acetylesterase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: carbohydrate metabolic process, regulation of immune system process; MF: carboxylic ester hydrolase activity, hydrolase activity, sialate 9-O-acetylesterase activity, sialate O-acetylesterase activity; CC: cytoplasm, lysosome
Pathways:
UniProt: P70665
Entrez ID: 22619
|
Does Knockout of Copb2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Copb2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Copb2 (COPI coat complex subunit beta 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: protein kinase C binding, structural molecule activity; CC: COPI vesicle coat, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, membrane, membrane coat
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O55029
Entrez ID: 50797
|
Does Knockout of Ggt7 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Ggt7
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Ggt7 (gamma-glutamyltransferase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutathione biosynthetic process, glutathione catabolic process, glutathione metabolic process, negative regulation of response to oxidative stress; MF: acyltransferase activity, glutathione hydrolase activity, hydrolase activity, leukotriene C4 gamma-glutamyl transferase activity, transferase activity; CC: membrane, plasma membrane
Pathways: γ-glutamyl cycle, Aflatoxin activation and detoxification, Biological oxidations, Drug ADME, Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Glutathione synthesis and recycling, Metabolism, Paracetamol ADME, Phase II - Conjugation of compounds, Taurine and hypotaurine metabolism - Mus musculus (mouse)
UniProt: Q99JP7
Entrez ID: 207182
|
Does Knockout of Zfp831 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Zfp831
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zfp831 (zinc finger protein 831)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: A2ADM8
Entrez ID: 100043757
|
Does Knockout of Bcs1l in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Bcs1l
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Bcs1l (BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone)
Type: protein-coding
Summary: The protein encoded by this gene is a chaperone protein that is involved in the assembly of complex III (CIII), one of the five protein complexes of the mitochondrial respiratory chain, and is necessary for the insertion of the Rieske iron-sulfur (RISP) and Qcr10p proteins into the precomplex. Studies from the yeast ortholog of this protein indicate that it is targeted to the inner membrane of the mitochondria, despite the absence of an N-terminal targeting sequence. Positively charged amino acids located C-terminal to the transmembrane domain are thought to act as an internal targeting signal (PMID:8599931). Mutations in the human ortholog of this gene have been associated with GRACILE syndrome, characterized by Growth retardation, Amino aciduria, Cholestasis, Iron overload, Lactic acidosis, and Early death. Mouse models with the corresponding mutation mimic the phenotype of GRACILE syndrome and display decreased complex III activity and decreased electron transport capacity (PMID:21274865). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly, mitochondrial respiratory chain complex I assembly, mitochondrial respiratory chain complex III assembly, mitochondrion organization, protein insertion into mitochondrial inner membrane from matrix, protein transmembrane transport; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, mitochondrial protein-transporting ATPase activity, nucleotide binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CZP5
Entrez ID: 66821
|
Does Knockout of Sec61a1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Sec61a1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sec61a1 (SEC61 translocon subunit alpha 1)
Type: protein-coding
Summary: Enables ribosome binding activity and transmembrane transporter activity. Involved in pronephric nephron development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Is expressed in cerebral cortex; jaw; skeleton; and vibrissa. Human ortholog(s) of this gene implicated in autosomal dominant tubulointerstitial kidney disease; common variable immunodeficiency; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, translocation, calcium ion transmembrane transport, cotranslational protein targeting to membrane, endoplasmic reticulum organization, post-translational protein targeting to endoplasmic reticulum membrane, post-translational protein targeting to membrane, translocation, pronephric nephron development, protein insertion into ER membrane, protein transport, response to type II interferon; MF: calcium channel activity, protein transmembrane transporter activity, ribosome binding, signal sequence binding, transmembrane transporter activity; CC: Sec61 translocon complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, phagocytic vesicle membrane
Pathways: Phagosome - Mus musculus (mouse), Protein export - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: P61620
Entrez ID: 53421
|
Does Knockout of Letm1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Letm1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Letm1 (leucine zipper-EF-hand containing transmembrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium export from the mitochondrion, calcium ion transport, cristae formation, inner mitochondrial membrane organization, mitochondrial calcium ion homeostasis, mitochondrial calcium ion transmembrane transport, mitochondrial potassium ion transmembrane transport, mitochondrion organization, monoatomic ion transport, negative regulation of mitochondrial calcium ion concentration, potassium ion transport, protein hexamerization, protein homooligomerization, proton transmembrane transport, regulation of cellular hyperosmotic salinity response; MF: antiporter activity, calcium:proton antiporter activity, metal ion binding, ribosome binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: RHO GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9Z2I0
Entrez ID: 56384
|
Does Knockout of Defa22 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Defa22
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Defa22 (defensin, alpha, 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, disruption of plasma membrane integrity in another organism, innate immune response; MF: pore-forming activity, protein homodimerization activity; CC: azurophil granule, extracellular region, extracellular space, midbody, secretory granule
Pathways: Alpha-defensins, Antimicrobial peptides, Defensins, Immune System, Innate Immune System, NOD-like receptor signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Staphylococcus aureus infection - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q8C1N8
Entrez ID: 382059
|
Does Knockout of Nhp2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Nhp2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nhp2 (NHP2 ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, rRNA pseudouridine synthesis, ribosome biogenesis, snRNA pseudouridine synthesis, snoRNA guided rRNA pseudouridine synthesis, telomere maintenance via telomerase; MF: RNA binding, U3 snoRNA binding, box H/ACA snoRNA binding, mRNA 3'-UTR binding, protein binding, telomerase RNA binding; CC: Cajal body, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, nucleolus, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q9CRB2
Entrez ID: 52530
|
Does Knockout of Papola in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Papola
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Papola (poly (A) polymerase alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, cytosolic mRNA polyadenylation, mRNA 3'-end processing, mRNA processing; MF: ATP binding, RNA binding, magnesium ion binding, manganese ion binding, metal ion binding, nucleotide binding, nucleotidyltransferase activity, poly(A) RNA polymerase activity, protein binding, transferase activity; CC: nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q61183
Entrez ID: 18789
|
Does Knockout of Rps26 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Rps26
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rps26 (ribosomal protein S26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, negative regulation of RNA splicing, translation, translation at postsynapse, translation at presynapse; MF: mRNA binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, postsynapse, presynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62855
Entrez ID: 27370
|
Does Knockout of Taf1a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Taf1a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Taf1a (TATA-box binding protein associated factor, RNA polymerase I, A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transcription by RNA polymerase I; MF: DNA binding, protein binding; CC: RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, microtubule cytoskeleton, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination
UniProt: P97357
Entrez ID: 21339
|
Does Knockout of Abcc1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Abcc1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Abcc1 (ATP-binding cassette, sub-family C member 1)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: NK T cell activation, amygdala development, amyloid-beta clearance, amyloid-beta metabolic process, antigen processing and presentation of lipid antigen via MHC class Ib, astrocyte differentiation, bilirubin transport, blood vessel diameter maintenance, carboxylic acid transmembrane transport, cell chemotaxis, cell redox homeostasis, cellular response to amyloid-beta, cellular response to type II interferon, cobalamin transport, cyclic nucleotide transport, defense response to Gram-positive bacterium, endothelial cell apoptotic process, endothelium development, establishment of localization in cell, exploration behavior, export across plasma membrane, export from cell, gene expression, glial cell differentiation, glucocorticoid metabolic process, glutathione metabolic process, glutathione transmembrane transport, granuloma formation, hippocampus development, hydrogen peroxide biosynthetic process, immune response, inflammatory response, inflammatory response to antigenic stimulus, intracellular chemical homeostasis, intracellular nitrogen homeostasis, leukotriene biosynthetic process, leukotriene metabolic process, leukotriene transport, lipid transport, long-chain fatty acid import across plasma membrane, lymphocyte migration, macrophage activation, memory, multicellular organism growth, neural tissue regeneration, neurogenesis, phospholipid efflux, phospholipid translocation, pigment accumulation, positive regulation of cell migration, positive regulation of inflammatory response, protein localization to cell surface, reactive oxygen species biosynthetic process, regulation of cellular response to drug, regulation of membrane potential, response to fluid shear stress, response to glucocorticoid, response to oxidative stress, response to toxic substance, response to type II interferon, response to xenobiotic stimulus, sphingolipid translocation, superoxide anion generation, tissue homeostasis, transepithelial transport, transmembrane transport, xenobiotic detoxification by transmembrane export across the plasma membrane, xenobiotic transmembrane transport, xenobiotic transport, xenobiotic transport across blood-brain barrier; MF: ABC-type glutathione S-conjugate transporter activity, ABC-type transporter activity, ABC-type vitamin B12 transporter activity, ABC-type xenobiotic transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled carboxylic acid transmembrane transporter activity, ATPase-coupled lipid transmembrane transporter activity, amide transmembrane transporter activity, bilirubin transmembrane transporter activity, carboxylic acid transmembrane transporter activity, efflux transmembrane transporter activity, glutathione transmembrane transporter activity, hydrolase activity, long-chain fatty acid transmembrane transporter activity, nucleotide binding, transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: apical plasma membrane, basal plasma membrane, basolateral plasma membrane, lateral plasma membrane, membrane, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse), ABC-family proteins mediated transport, Arachidonate metabolism, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cobalamin (Cbl, vitamin B12) transport and metabolism, Cytoprotection by HMOX1, Drug ADME, Fatty acid metabolism, Heme degradation, Metabolism, Metabolism of lipids, Metabolism of porphyrins, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, MicroRNAs in cancer - Mus musculus (mouse), Paracetamol ADME, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid signaling pathway - Mus musculus (mouse), Synthesis of Leukotrienes (LT) and Eoxins (EX), Transport of RCbl within the body, Transport of small molecules, Vitamin digestion and absorption - Mus musculus (mouse)
UniProt: O35379
Entrez ID: 17250
|
Does Knockout of Pigf in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Pigf
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pigf (phosphatidylinositol glycan anchor biosynthesis, class F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Synthesis of glycosylphosphatidylinositol (GPI), phosphatidylethanolamine biosynthesis II
UniProt: O09101
Entrez ID: 18701
|
Does Knockout of Mapre2 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Mapre2
|
cell proliferation
|
Regulatory T cell
|
Gene: Mapre2 (microtubule-associated protein, RP/EB family, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, positive regulation of ARF protein signal transduction, positive regulation of focal adhesion disassembly, positive regulation of keratinocyte migration, protein localization to microtubule, regulation of microtubule polymerization or depolymerization, spindle assembly; MF: identical protein binding, microtubule binding, microtubule plus-end binding, protein binding, protein kinase binding; CC: cytoplasm, cytoplasmic microtubule, cytoskeleton, focal adhesion, microtubule, microtubule cytoskeleton, microtubule organizing center, microtubule plus-end, spindle, spindle midzone
Pathways:
UniProt: Q8R001
Entrez ID: 212307
|
Does Knockout of Sfpq in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Sfpq
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sfpq (splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, RNA splicing, activation of innate immune response, alternative mRNA splicing, via spliceosome, chromatin remodeling, chromosome organization, dendritic transport of messenger ribonucleoprotein complex, double-strand break repair via homologous recombination, immune system process, innate immune response, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of circadian rhythm, negative regulation of transcription by RNA polymerase II, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of sister chromatid cohesion, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of circadian rhythm, rhythmic process; MF: DNA binding, RNA binding, chromatin binding, histone deacetylase binding, nucleic acid binding, protein binding, protein homodimerization activity, transcription cis-regulatory region binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, dendrite, nuclear matrix, nuclear speck, nucleoplasm, nucleus, paraspeckles
Pathways: PTK6 Regulates Proteins Involved in RNA Processing, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6
UniProt: Q8VIJ6
Entrez ID: 71514
|
Does Knockout of Etv2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Etv2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Etv2 (ets variant 2)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of endothelial cell differentiation; and positive regulation of mesoderm development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in limb ischemia. Orthologous to human ETV2 (ETS variant transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: BMP signaling pathway, Notch signaling pathway, Wnt signaling pathway, blastocyst development, blood vessel morphogenesis, cell differentiation, erythrocyte differentiation, hemopoiesis, in utero embryonic development, mesoderm formation, mesodermal cell fate specification, placenta development, positive regulation of endothelial cell differentiation, positive regulation of gene expression, positive regulation of mesoderm development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: P41163
Entrez ID: 14008
|
Does Knockout of Bglap2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 2,176
|
Knockout
|
Bglap2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Bglap2 (bone gamma-carboxyglutamate protein 2)
Type: protein-coding
Summary: This gene encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a hormone that is secreted by osteoblasts and may function in bone remodeling and energy metabolism. Homozygous knockout mice for this gene exhibit a gradual increase in bone size, density and strength, as well as elevated adiposity and impaired glucose tolerance. This gene is present in a gene cluster with other related genes on chromosome 3. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: biomineral tissue development, bone development, brain development, cellular response to insulin stimulus, cognition, glucose homeostasis, learning or memory, lipid catabolic process, negative regulation of bone development, osteoblast differentiation, pancreas development, positive regulation of insulin secretion, positive regulation of neurotransmitter secretion, regulation of bone mineralization, regulation of cellular response to insulin stimulus, regulation of testosterone biosynthetic process, response to vitamin K, signal transduction, system development, type B pancreatic cell proliferation; MF: calcium ion binding, hormone activity, hydroxyapatite binding, metal ion binding, structural constituent of bone; CC: cell projection, cytoplasm, dendrite, extracellular region, extracellular space, perikaryon, vesicle
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Gamma-carboxylation of protein precursors, Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Metabolism of proteins, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Post-translational protein modification, Removal of aminoterminal propeptides from gamma-carboxylated proteins, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
UniProt: P86547
Entrez ID: 12097
|
Does Knockout of Rflna in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Rflna
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rflna (refilin A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament bundle organization, negative regulation of bone mineralization involved in bone maturation, negative regulation of chondrocyte development, regulation of chondrocyte development, skeletal system morphogenesis; MF: filamin binding; CC: actin filament bundle, cytoplasm, cytoskeleton
Pathways:
UniProt: Q7TS73
Entrez ID: 73121
|
Does Knockout of Commd6 in macrophage causally result in phagocytosis?
| 1
| 1,888
|
Knockout
|
Commd6
|
phagocytosis
|
macrophage
|
Gene: Commd6 (COMM domain containing 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: NF-kappaB binding; CC: cellular_component, cytoplasm, nucleus
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q3V4B5
Entrez ID: 66200
|
Does Knockout of Slc38a2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Slc38a2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc38a2 (solute carrier family 38, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamine import across plasma membrane, L-proline import across plasma membrane, L-serine import across plasma membrane, L-serine transport, acidic amino acid transport, alanine transport, amino acid import, amino acid transmembrane transport, amino acid transport, cellular response to amino acid starvation, cellular response to arsenite(3-), cellular response to mechanical stimulus, cerebral cortex development, female pregnancy, glutamine transport, glycine betaine transport, monoatomic ion transport, neutral amino acid transport, positive regulation of RNA splicing, positive regulation of gene expression, proline transport, regulation of cellular response to stress, regulation of glutamate secretion, neurotransmission, response to muscle activity, sodium ion transmembrane transport, sodium ion transport; MF: L-glutamine transmembrane transporter activity, L-serine transmembrane transporter activity, acidic amino acid transmembrane transporter activity, alanine:sodium symporter activity, amino acid transmembrane transporter activity, amino acid:sodium symporter activity, neutral L-amino acid transmembrane transporter activity, neutral L-amino acid:sodium symporter activity, proline:sodium symporter activity, symporter activity; CC: axon, brush border, cytoplasm, dendrite, membrane, neuronal cell body, plasma membrane, sarcolemma
Pathways: Amino acid transport across the plasma membrane, GABAergic synapse - Mus musculus (mouse), Glutamate Neurotransmitter Release Cycle, Glutamatergic synapse - Mus musculus (mouse), Neuronal System, Neurotransmitter release cycle, Protein digestion and absorption - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transmission across Chemical Synapses, Transport of small molecules
UniProt: Q8CFE6
Entrez ID: 67760
|
Does Knockout of Impa2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Impa2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Impa2 (inositol monophosphatase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inositol biosynthetic process, inositol metabolic process, phosphatidylinositol phosphate biosynthetic process, response to lithium ion, signal transduction; MF: glucose-1-phosphatase activity, glycerol-2-phosphatase activity, hydrolase activity, inositol monophosphate 1-phosphatase activity, inositol monophosphate 3-phosphatase activity, inositol monophosphate 4-phosphatase activity, inositol monophosphate phosphatase activity, metal ion binding, protein homodimerization activity; CC: cytoplasm
Pathways: <i>myo</i>-inositol biosynthesis, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Synthesis of IP2, IP, and Ins in the cytosol
UniProt: Q91UZ5
Entrez ID: 114663
|
Does Knockout of Ssu72 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Ssu72
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ssu72 (Ssu72 RNA polymerase II CTD phosphatase homolog (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA processing, regulation of transcription by RNA polymerase II, termination of RNA polymerase II transcription; MF: RNA polymerase II CTD heptapeptide repeat phosphatase activity, hydrolase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: cytoplasm, cytosol, mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9CY97
Entrez ID: 68991
|
Does Knockout of Timm8a1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Timm8a1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Timm8a1 (translocase of inner mitochondrial membrane 8A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein insertion into mitochondrial inner membrane, protein targeting to mitochondrion, protein transport; MF: identical protein binding, metal ion binding, zinc ion binding; CC: membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial intermembrane space chaperone complex, mitochondrion
Pathways:
UniProt: Q9WVA2
Entrez ID: 30058
|
Does Knockout of Atp6ap1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Atp6ap1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Atp6ap1 (ATPase, H+ transporting, lysosomal accessory protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to increased oxygen levels, endosome to plasma membrane protein transport, intracellular iron ion homeostasis, monoatomic ion transport, osteoclast development, proton transmembrane transport, proton-transporting V-type ATPase complex assembly, regulation of cellular pH, synaptic vesicle lumen acidification; MF: ATPase activator activity, small GTPase binding, transporter activator activity; CC: bounding membrane of organelle, clathrin-coated vesicle membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, endosome membrane, membrane, proton-transporting V-type ATPase complex, synapse, synaptic vesicle membrane
Pathways: Hepatitis B - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), RHO GTPase cycle, RHOA GTPase cycle, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Mus musculus (mouse)
UniProt: Q9R1Q9
Entrez ID: 54411
|
Does Knockout of Spx in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Spx
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Spx (spexin hormone)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: long-chain fatty acid import into cell, negative regulation of appetite, negative regulation of heart rate, negative regulation of renal sodium excretion, positive regulation of gastro-intestinal system smooth muscle contraction, positive regulation of systemic arterial blood pressure, positive regulation of transcription by RNA polymerase II, regulation of sensory perception of pain, signal transduction; MF: hormone activity, neuropeptide hormone activity, type 2 galanin receptor binding, type 3 galanin receptor binding; CC: cytoplasm, cytoplasmic vesicle, dense core granule, extracellular region, extracellular space, transport vesicle
Pathways:
UniProt: D3Z752
Entrez ID: 319552
|
Does Knockout of Nccrp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Nccrp1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nccrp1 (non-specific cytotoxic cell receptor protein 1 homolog (zebrafish))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, glycoprotein catabolic process, positive regulation of cell population proliferation; CC: SCF ubiquitin ligase complex, cytoplasm, cytosol
Pathways:
UniProt: G3X9C2
Entrez ID: 233038
|
Does Knockout of Zswim7 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Zswim7
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Zswim7 (zinc finger SWIM-type containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, double-strand break repair via homologous recombination, protein stabilization; MF: metal ion binding, zinc ion binding; CC: Shu complex, nucleus
Pathways:
UniProt: Q9CWQ2
Entrez ID: 69747
|
Does Knockout of Ncor2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ncor2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ncor2 (nuclear receptor co-repressor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell proliferation in forebrain, epidermis development, establishment of skin barrier, forebrain development, gene expression, glucose homeostasis, heart morphogenesis, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of androgen receptor signaling pathway, negative regulation of miRNA transcription, negative regulation of transcription by RNA polymerase II, negative regulation of white fat cell differentiation, protein stabilization, random inactivation of X chromosome, regulation of ketone metabolic process, telencephalon development, type I pneumocyte differentiation, white fat cell differentiation; MF: DNA binding, Notch binding, chromatin binding, enzyme activator activity, histone deacetylase binding, nuclear glucocorticoid receptor binding, nuclear receptor binding, nuclear retinoic acid receptor binding, nuclear retinoid X receptor binding, protein binding, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription corepressor activity; CC: chromatin, histone deacetylase complex, nuclear body, nuclear matrix, nucleoplasm, nucleus, protein-containing complex, transcription repressor complex
Pathways: Adipogenesis, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Cytoprotection by HMOX1, Developmental Biology, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Epstein-Barr virus infection - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Notch signaling pathway - Mus musculus (mouse), Notch-HLH transcription pathway, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription, Regulation of lipid metabolism by PPARalpha, Signal Transduction, Signaling by Nuclear Receptors, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation of white adipocyte differentiation
UniProt: Q9WU42
Entrez ID: 20602
|
Does Knockout of Kif17 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Kif17
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Kif17 (kinesin family member 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde dendritic transport of neurotransmitter receptor complex, cell projection organization, intraciliary transport, microtubule-based movement, microtubule-based process, protein transport, protein-containing complex localization, vesicle-mediated transport; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein binding; CC: axoneme, cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, dendrite, dendrite cytoplasm, kinesin complex, microtubule, microtubule cytoskeleton, microtubule organizing center, neuron projection, periciliary membrane compartment, photoreceptor connecting cilium, photoreceptor inner segment, photoreceptor outer segment, postsynapse
Pathways: Cilium Assembly, Intraflagellar transport, Organelle biogenesis and maintenance
UniProt: Q99PW8
Entrez ID: 16559
|
Does Knockout of Gpr174 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Gpr174
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gpr174 (G protein-coupled receptor 174)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, T cell homeostasis, adenylate cyclase-activating G protein-coupled receptor signaling pathway, negative regulation of interleukin-2 production, signal transduction; MF: G protein-coupled receptor activity, bioactive lipid receptor activity; CC: centriolar satellite, membrane, plasma membrane
Pathways:
UniProt: Q3U507
Entrez ID: 213439
|
Does Knockout of Fam162b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Fam162b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fam162b (family with sequence similarity 162, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q9CX19
Entrez ID: 77296
|
Does Knockout of Ascc2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Ascc2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ascc2 (activating signal cointegrator 1 complex subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, regulation of DNA-templated transcription, rescue of stalled ribosome, ribosome disassembly, ribosome-associated ubiquitin-dependent protein catabolic process; MF: K63-linked polyubiquitin modification-dependent protein binding, ubiquitin binding; CC: DNA repair complex, RQC-trigger complex, cytosolic ribosome, nuclear speck, nucleus
Pathways: Metabolism of proteins, Ribosome-associated quality control, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
UniProt: Q91WR3
Entrez ID: 75452
|
Does Knockout of Pinlyp in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Pinlyp
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pinlyp (phospholipase A2 inhibitor and LY6/PLAUR domain containing)
Type: protein-coding
Summary: Predicted to enable phospholipase inhibitor activity. Predicted to be located in extracellular region. Orthologous to human PINLYP (phospholipase A2 inhibitor and LY6/PLAUR domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: molecular_function, phospholipase inhibitor activity; CC: cellular_component, extracellular region
Pathways:
UniProt: Q9CQD7
Entrez ID: 641361
|
Does Knockout of Sod3 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Sod3
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Sod3 (superoxide dismutase 3, extracellular)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel diameter maintenance, removal of superoxide radicals, response to copper ion, response to hypoxia, superoxide metabolic process; MF: antioxidant activity, copper ion binding, metal ion binding, molecular adaptor activity, oxidoreductase activity, protein binding, superoxide dismutase activity; CC: Golgi apparatus, Golgi lumen, cytoplasm, extracellular matrix, extracellular region, extracellular space, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, superoxide radicals degradation
UniProt: O09164
Entrez ID: 20657
|
Does Knockout of Traf3ip2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Traf3ip2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Traf3ip2 (TRAF3 interacting protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell affinity maturation, B cell apoptotic process, B cell homeostasis, B cell mediated immunity, CD40 signaling pathway, T cell activation, T cell differentiation, T-helper 17 type immune response, cellular response to cytokine stimulus, cellular response to interleukin-17, cytokine-mediated signaling pathway, eosinophil homeostasis, eosinophil mediated immunity, establishment of T cell polarity, gene expression, heart development, humoral immune response, immune response, inflammatory response, interleukin-17-mediated signaling pathway, interleukin-17A-mediated signaling pathway, kidney development, leukocyte activation involved in inflammatory response, lymph node development, mRNA stabilization, mucus secretion, negative regulation of interleukin-17-mediated signaling pathway, neutrophil activation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of defense response to virus by host, protein K63-linked ubiquitination, protein import into nucleus, protein localization to P-body, protein localization to nucleus, protein polyubiquitination, protein ubiquitination, response to cytokine, response to xenobiotic stimulus, signal transduction involved in regulation of gene expression, skin development, spleen development, transitional two stage B cell differentiation, tumor necrosis factor-mediated signaling pathway, type 2 immune response; MF: protein binding, signaling receptor binding, transferase activity, ubiquitin protein ligase activity; CC: cytoplasm, cytoplasmic vesicle, nucleus
Pathways: Cellular senescence - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse)
UniProt: Q8N7N6
Entrez ID: 103213
|
Does Knockout of Hsbp1l1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Hsbp1l1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Hsbp1l1 (heat shock factor binding protein 1-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular heat acclimation, negative regulation of DNA-templated transcription; MF: molecular_function, transcription corepressor activity; CC: cytosol, nucleus
Pathways:
UniProt: B2RXB2
Entrez ID: 66255
|
Does Knockout of Slc25a17 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Slc25a17
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Slc25a17 (solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ADP transport, AMP transport, ATP transport, FAD transmembrane transport, NAD transmembrane transport, NAD transport, coenzyme A transmembrane transport, fatty acid beta-oxidation, fatty acid transport, nucleotide transmembrane transport, transmembrane transport; MF: ADP transmembrane transporter activity, AMP transmembrane transporter activity, ATP transmembrane transporter activity, FAD transmembrane transporter activity, FMN transmembrane transporter activity, NAD transmembrane transporter activity, antiporter activity, coenzyme A transmembrane transporter activity, protein-folding chaperone binding; CC: cytoplasm, membrane, mitochondrion, peroxisomal membrane, peroxisome
Pathways: Alpha-oxidation of phytanate, Class I peroxisomal membrane protein import, Fatty acid metabolism, Metabolism, Metabolism of lipids, Peroxisomal lipid metabolism, Peroxisome - Mus musculus (mouse), Protein localization
UniProt: O70579
Entrez ID: 20524
|
Does Knockout of Esp6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Esp6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Esp6 (exocrine gland secreted peptide 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, signal transduction; MF: pheromone activity; CC: extracellular space, membrane
Pathways:
UniProt: A0A3B2WD20, A8R0U0
Entrez ID: 433107
|
Does Knockout of Wdr62 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Wdr62
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Wdr62 (WD repeat domain 62)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, cerebral cortex development, mitotic spindle organization, neurogenesis, neuronal stem cell population maintenance, positive regulation of neuroblast proliferation, positive regulation of neuron migration, regulation of centrosome cycle, regulation of neuron differentiation; CC: centriolar satellite, centriole, centrosome, cytoplasm, cytoskeleton, cytosol, nucleus, spindle pole
Pathways:
UniProt: E9PUI7, E9QK36, F6R9F0
Entrez ID: 233064
|
Does Knockout of Nav1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Nav1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nav1 (neuron navigator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, microtubule bundle formation, nervous system development, neurogenesis, neuron migration; CC: axon initial segment, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton
Pathways:
UniProt: Q8CH77
Entrez ID: 215690
|
Does Knockout of Grcc10 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Grcc10
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Grcc10 (gene rich cluster, C10 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye morphogenesis, cognition, corpus callosum morphogenesis, post-embryonic development, psychomotor behavior, regulation of skeletal muscle contraction, third ventricle development; CC: cytoplasm, nuclear speck
Pathways:
UniProt: O35127
Entrez ID: 14790
|
Does Knockout of Supv3l1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Supv3l1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Supv3l1 (suppressor of var1, 3-like 1 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA recombination, RNA catabolic process, mitochondrial RNA 3'-end processing, mitochondrial RNA surveillance, mitochondrial mRNA catabolic process, mitochondrial mRNA surveillance, mitochondrial ncRNA surveillance, mitochondrion organization, negative regulation of apoptotic process, positive regulation of cell growth, positive regulation of mitochondrial RNA catabolic process; MF: 3'-5' RNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, nucleotide binding, protein homodimerization activity; CC: mitochondrial degradosome, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleus
Pathways:
UniProt: Q80YD1
Entrez ID: 338359
|
Does Knockout of Kctd5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Kctd5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kctd5 (potassium channel tetramerisation domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein homooligomerization; MF: cullin family protein binding, identical protein binding, protein binding, protein-containing complex binding; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8VC57
Entrez ID: 69259
|
Does Knockout of Ddx49 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Ddx49
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ddx49 (DEAD box helicase 49)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in positive regulation of cell growth; rRNA processing; and regulation of rRNA stability. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DDX49 (DEAD-box helicase 49). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: positive regulation of cell growth, rRNA processing, regulation of rRNA stability; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q4FZF3
Entrez ID: 234374
|
Does Knockout of Junb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Junb
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Junb (jun B proto-oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to calcium ion, decidualization, embryonic process involved in female pregnancy, in utero embryonic development, labyrinthine layer blood vessel development, osteoblast differentiation, osteoblast proliferation, osteoclast differentiation, osteoclast proliferation, positive regulation of cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell population proliferation, response to steroid hormone, transcription by RNA polymerase II, trophectodermal cell differentiation, vasculogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, nucleoplasm, nucleus, transcription factor AP-1 complex, transcription regulator complex
Pathways: Growth hormone synthesis, secretion and action - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: P09450
Entrez ID: 16477
|
Does Knockout of Acss2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Acss2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Acss2 (acyl-CoA synthetase short-chain family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetate biosynthetic process, acetyl-CoA biosynthetic process, lipid biosynthetic process, lipid metabolic process, long-term memory, positive regulation of DNA-templated transcription, propionate biosynthetic process, small molecule metabolic process; MF: ATP binding, acetate-CoA ligase activity, chromatin binding, ligase activity, nucleotide binding, propionate-CoA ligase activity, protein binding, transcription coactivator activity; CC: cytoplasm, cytosol, nucleus
Pathways: Biological oxidations, Ethanol oxidation, Glycolysis / Gluconeogenesis - Mus musculus (mouse), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Metabolism, Mitochondrial biogenesis, Organelle biogenesis and maintenance, Phase I - Functionalization of compounds, Propanoate metabolism - Mus musculus (mouse), Pyruvate metabolism - Mus musculus (mouse), Transcriptional activation of mitochondrial biogenesis, acetate conversion to acetyl-CoA, ethanol degradation II (cytosol)
UniProt: Q9QXG4
Entrez ID: 60525
|
Does Knockout of Tax1bp3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Tax1bp3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tax1bp3 (Tax1 (human T cell leukemia virus type I) binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, Wnt signaling pathway, negative regulation of Wnt signaling pathway, negative regulation of cell population proliferation, negative regulation of protein localization to cell surface, regulation of Cdc42 protein signal transduction; MF: beta-catenin binding, protein binding; CC: actin cytoskeleton, cytoplasm, fibrillar center, membrane, nucleus, plasma membrane
Pathways: RHO GTPase Effectors, RHO GTPases Activate Rhotekin and Rhophilins, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9DBG9
Entrez ID: 76281
|
Does Knockout of Zfp330 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Zfp330
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zfp330 (zinc finger protein 330)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be located in chromosome, centromeric region; midbody; and nuclear lumen. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human ZNF330 (zinc finger protein 330). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: MF: metal ion binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, ciliary basal body, cilium, cytosol, midbody, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q922H9
Entrez ID: 30932
|
Does Knockout of Cdc73 in Regulatory T cell causally result in protein/peptide accumulation?
| 1
| 1,482
|
Knockout
|
Cdc73
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Cdc73 (cell division cycle 73, Paf1/RNA polymerase II complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, cellular response to lipopolysaccharide, endodermal cell fate commitment, mRNA 3'-end processing, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation, negative regulation of fibroblast proliferation, negative regulation of myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of Wnt signaling pathway, positive regulation of cell cycle G1/S phase transition, positive regulation of mRNA 3'-end processing, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, protein destabilization, regulation of cell growth, regulation of transcription by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, protein binding; CC: Cdc73/Paf1 complex, cytosol, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Formation of RNA Pol II elongation complex , Formation of the beta-catenin:TCF transactivating complex, Gene expression (Transcription), Hedgehog 'on' state, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Signal Transduction, Signaling by Hedgehog, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q8JZM7
Entrez ID: 214498
|
Does Knockout of Cyp4a12b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Cyp4a12b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cyp4a12b (cytochrome P450, family 4, subfamily a, polypeptide 12B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, fatty acid metabolic process, icosanoid biosynthetic process, kidney development, lauric acid metabolic process, linoleic acid metabolic process, omega-hydroxylase P450 pathway; MF: 16-hydroxypalmitate dehydrogenase activity, alkane 1-monooxygenase activity, arachidonate epoxygenase activity, arachidonate monooxygenase activity, arachidonate omega-hydroxylase activity, fatty acid omega-hydroxylase activity, heme binding, iron ion binding, leukotriene-B4 20-monooxygenase activity, long-chain fatty acid omega-hydroxylase activity, medium-chain fatty acid omega-hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: apical plasma membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular space, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Fatty acids, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Metabolism, Metabolism of lipids, Miscellaneous substrates, PPAR signaling pathway - Mus musculus (mouse), Phase I - Functionalization of compounds, Retinol metabolism - Mus musculus (mouse), Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE), Synthesis of Leukotrienes (LT) and Eoxins (EX), Vascular smooth muscle contraction - Mus musculus (mouse)
UniProt: A2A974
Entrez ID: 13118
|
Does Knockout of Cep72 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Cep72
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cep72 (centrosomal protein 72)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, gamma-tubulin complex localization, regulation of protein localization to centrosome, spindle organization; CC: centriolar satellite, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9D3R3
Entrez ID: 74470
|
Does Knockout of Fpr-rs3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Fpr-rs3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Fpr-rs3 (formyl peptide receptor, related sequence 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, chemotaxis, complement receptor mediated signaling pathway, inflammatory response, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, signal transduction; MF: G protein-coupled receptor activity, N-formyl peptide receptor activity, complement receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Formyl peptide receptors bind formyl peptides and many other ligands, G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: O88537
Entrez ID: 14290
|
Does Knockout of Farsa in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Farsa
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Farsa (phenylalanyl-tRNA synthetase, alpha subunit)
Type: protein-coding
Summary: Predicted to enable magnesium ion binding activity and phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Predicted to be part of phenylalanine-tRNA ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and respiratory system. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: phenylalanyl-tRNA aminoacylation, protein heterotetramerization, tRNA aminoacylation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, magnesium ion binding, metal ion binding, nucleotide binding, phenylalanine-tRNA ligase activity, tRNA binding; CC: cytoplasm, phenylalanine-tRNA ligase complex
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8C0C7
Entrez ID: 66590
|
Does Knockout of Invs in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Invs
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Invs (inversin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, animal organ development, embryonic heart tube left/right pattern formation, epithelial cilium movement involved in determination of left/right asymmetry, kidney development, negative regulation of canonical Wnt signaling pathway, pancreas development, post-embryonic development, protein localization to ciliary inversin compartment; MF: calmodulin binding, protein binding; CC: ciliary base, ciliary inversin compartment, cilium, cytoplasm, cytoskeleton, extracellular region, membrane, microtubule, nucleus, perinuclear region of cytoplasm, spindle
Pathways: Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q3TYB3, A2AM57, A0JNT0, S4R2B7
Entrez ID: 16348
|
Does Knockout of Defb18 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Defb18
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Defb18 (defensin beta 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, defense response, defense response to bacterium, innate immune response; CC: cellular_component, extracellular region
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q30KP5
Entrez ID: 654460
|
Does Knockout of Bicc1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Bicc1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Bicc1 (BicC family RNA binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: determination of left/right symmetry, heart development, kidney development, mRNA catabolic process, negative regulation of canonical Wnt signaling pathway; MF: RNA binding, nucleic acid binding, protein binding; CC: cytoplasm
Pathways:
UniProt: Q99MQ1
Entrez ID: 83675
|
Does Knockout of C1qtnf3 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
C1qtnf3
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: C1qtnf3 (C1q and tumor necrosis factor related protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chemical homeostasis, glucose homeostasis, intracellular triglyceride homeostasis, negative regulation of gene expression, negative regulation of gluconeogenesis, negative regulation of inflammatory response, negative regulation of interleukin-6 production, negative regulation of monocyte chemotactic protein-1 production, negative regulation of non-canonical NF-kappaB signal transduction, positive regulation of ERK1 and ERK2 cascade, positive regulation of adiponectin secretion, positive regulation of cytokine production, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of intracellular signal transduction; MF: identical protein binding; CC: collagen trimer, extracellular region, extracellular space, protein-containing complex
Pathways:
UniProt: Q9ES30
Entrez ID: 81799
|
Does Knockout of Snupn in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Snupn
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Snupn (snurportin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA import into nucleus, cytoskeleton organization, protein complex oligomerization, protein import into nucleus, protein tetramerization, snRNA import into nucleus; MF: RNA binding, RNA cap binding, molecular_function, nuclear import signal receptor activity; CC: NLS-dependent protein nuclear import complex, cytoplasm, cytosol, nuclear pore, nucleoplasm, nucleus, plasma membrane
Pathways: Metabolism of RNA, Metabolism of non-coding RNA, Nucleocytoplasmic transport - Mus musculus (mouse), snRNP Assembly
UniProt: Q80W37
Entrez ID: 66069
|
Does Knockout of Dap3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Dap3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dap3 (death associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic mitochondrial changes, apoptotic process, mitochondrial translation; MF: GTPase activity, hydrolase activity, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrial small ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9ER88
Entrez ID: 65111
|
Does Knockout of Kcnk5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Kcnk5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kcnk5 (potassium channel, subfamily K, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion export across plasma membrane, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of resting membrane potential; MF: outward rectifier potassium channel activity, potassium channel activity, potassium ion leak channel activity, protein heterodimerization activity, voltage-gated potassium channel activity; CC: membrane, plasma membrane
Pathways: Cardiac conduction, Muscle contraction, Phase 4 - resting membrane potential, Protein digestion and absorption - Mus musculus (mouse), Taste transduction - Mus musculus (mouse)
UniProt: Q9JK62
Entrez ID: 16529
|
Does Knockout of Tnxb in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Tnxb
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tnxb (tenascin XB)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion, cell-matrix adhesion, collagen fibril organization, collagen metabolic process, elastic fiber assembly, extracellular matrix organization, fatty acid metabolic process, lipid metabolic process, neuron projection development, positive regulation of collagen fibril organization, regulation of JNK cascade, regulation of cell adhesion, triglyceride metabolic process; MF: collagen binding, collagen fibril binding, heparin binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways: ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse)
UniProt: A0A5F8MPH8, A0A571BG59, E9Q2T3, O35452
Entrez ID: 81877
|
Does Knockout of Scfd1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Scfd1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Scfd1 (Sec1 family domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, negative regulation of autophagosome assembly, post-Golgi vesicle-mediated transport, protein transport, regulation of ER to Golgi vesicle-mediated transport, regulation of protein transport, response to toxic substance, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: protein-containing complex binding, syntaxin binding; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, Golgi-associated vesicle, cis-Golgi network, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q8BRF7
Entrez ID: 76983
|
Does Knockout of Cdkn1a in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,491
|
Knockout
|
Cdkn1a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cdkn1a (cyclin dependent kinase inhibitor 1A)
Type: protein-coding
Summary: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at the G1 pahse. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, Ras protein signal transduction, cellular response to UV-B, cellular response to amino acid starvation, cellular response to cell-matrix adhesion, cellular response to gamma radiation, cellular response to ionizing radiation, cellular senescence, epidermis development, fibroblast proliferation, heart development, import into nucleus, in utero embryonic development, intrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, keratinocyte differentiation, keratinocyte proliferation, mitotic G1 DNA damage checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, negative regulation of DNA biosynthetic process, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of apoptotic process, negative regulation of cardiac muscle tissue regeneration, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of growth, negative regulation of macromolecule biosynthetic process, negative regulation of vascular associated smooth muscle cell proliferation, oncogene-induced cell senescence, positive regulation of B cell proliferation, positive regulation of cell population proliferation, positive regulation of fibroblast proliferation, positive regulation of programmed cell death, positive regulation of reactive oxygen species metabolic process, protein import into nucleus, regulation of DNA biosynthetic process, regulation of G1/S transition of mitotic cell cycle, regulation of G2/M transition of mitotic cell cycle, regulation of cell cycle, regulation of cell cycle G1/S phase transition, regulation of mitotic cell cycle, response to UV, signal transduction by p53 class mediator, signal transduction in response to DNA damage, tissue regeneration, wound healing; MF: cyclin binding, cyclin-dependent protein serine/threonine kinase inhibitor activity, metal ion binding, molecular function activator activity, molecular function inhibitor activity, protein binding, protein kinase binding, protein kinase inhibitor activity, protein sequestering activity, protein serine/threonine kinase binding, protein-containing complex binding, ubiquitin protein ligase binding, zinc ion binding; CC: PCNA-p21 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, nuclear body, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: AKT phosphorylates targets in the cytosol, Basal cell carcinoma - Mus musculus (mouse), Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA Damage/Telomere Stress Induced Senescence, Developmental Biology, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G1 Phase, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Transition, Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glioma - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Non-small cell lung cancer - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PIP3 activates AKT signaling, Pancreatic cancer - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Renal cell carcinoma - Mus musculus (mouse), S Phase, SCF(Skp2)-mediated degradation of p27/p21, Senescence-Associated Secretory Phenotype (SASP), Signal Transduction, Small cell lung cancer - Mus musculus (mouse), TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, The role of GTSE1 in G2/M progression after G2 checkpoint, Thyroid cancer - Mus musculus (mouse), Transcriptional Regulation by TP53, Transcriptional misregulation in cancer - Mus musculus (mouse), Transcriptional regulation of granulopoiesis, Viral carcinogenesis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint
UniProt: P39689
Entrez ID: 12575
|
Does Knockout of Tas2r110 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Tas2r110
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tas2r110 (taste receptor, type 2, member 110)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: Q7M712
Entrez ID: 387344
|
Does Knockout of Mcm8 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Mcm8
|
cell cycle progression
|
breast epithelium
|
Gene: Mcm8 (minichromosome maintenance 8 homologous recombination repair factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, double-strand break repair via homologous recombination, female gamete generation, male gamete generation, protein localization to chromatin, protein stabilization, recombinational interstrand cross-link repair; MF: ATP binding, ATP hydrolysis activity, DNA binding, MutLbeta complex binding, MutSalpha complex binding, MutSbeta complex binding, chromatin binding, enzyme binding, helicase activity, hydrolase activity, nucleotide binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: MCM complex, MCM8-MCM9 complex, chromosome, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, CDC6 association with the ORC:origin complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: Q9CWV1
Entrez ID: 66634
|
Does Knockout of Heatr1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Heatr1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Heatr1 (HEAT repeat containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), neural precursor cell proliferation, positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, protein localization to nucleolus, rRNA metabolic process, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; CC: 90S preribosome, fibrillar center, mitochondrion, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome, t-UTP complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: A0A1Y7VNI1, G3X9B1, A0A1Y7VNG8
Entrez ID: 217995
|
Does Knockout of Tamm41 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Tamm41
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Tamm41 (TAM41 mitochondrial translocator assembly and maintenance homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, cardiolipin biosynthetic process, lipid metabolic process, phospholipid biosynthetic process; MF: nucleotidyltransferase activity, phosphatidate cytidylyltransferase activity, transferase activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: G3UWL8, G5E881, G3UYJ1, D6RGT1
Entrez ID: 68971
|
Does Knockout of Bsx in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Bsx
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Bsx (brain specific homeobox)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cell differentiation, eating behavior, locomotory behavior, mammary gland involution, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, stem cell population maintenance; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q810B3
Entrez ID: 244813
|
Does Knockout of Defb47 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Defb47
|
phagocytosis
|
macrophage
|
Gene: Defb47 (defensin beta 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, defense response to bacterium, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity; CC: cytosol, extracellular region, extracellular space
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q30KN1
Entrez ID: 654465
|
Does Knockout of Ifrd2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Ifrd2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Ifrd2 (interferon-related developmental regulator 2)
Type: protein-coding
Summary: Predicted to enable ribosome binding activity and translation repressor activity. Acts upstream of or within several processes, including Wnt signaling pathway; adipose tissue development; and fat cell differentiation. Is expressed in several structures, including alimentary system; blood; embryo mesenchyme; extraembryonic component; and neural ectoderm. Orthologous to human IFRD2 (interferon related developmental regulator 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Wnt signaling pathway, adipose tissue development, biological_process, fat cell differentiation, negative regulation of translation, regulation of translation; MF: molecular_function, ribosome binding, translation repressor activity
Pathways:
UniProt: Q9D8U0
Entrez ID: 15983
|
Does Knockout of Agpat2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Agpat2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Agpat2 (1-acylglycerol-3-phosphate O-acyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, epidermis development, lipid metabolic process, phosphatidic acid biosynthetic process, phospholipid biosynthetic process, positive regulation of cytokine production, response to xenobiotic stimulus, triglyceride biosynthetic process; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, Fat digestion and absorption - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of lipids, Neutrophil degranulation, Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Synthesis of PA, phosphatidylglycerol biosynthesis I (plastidic), phosphatidylglycerol biosynthesis II (non-plastidic), phospholipid biosynthesis I, triacylglycerol biosynthesis
UniProt: Q8K3K7
Entrez ID: 67512
|
Does Knockout of Epb42 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Epb42
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Epb42 (erythrocyte membrane protein band 4.2)
Type: protein-coding
Summary: The protein encoded by this gene is the key component of a macromolecular complex involved in the structure of erythrocytes. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: cell morphogenesis, erythrocyte maturation, hemoglobin metabolic process, monoatomic ion homeostasis, multicellular organismal-level iron ion homeostasis, regulation of cell shape, spleen development; MF: protein-glutamine gamma-glutamyltransferase activity; CC: ankyrin-1 complex, cell periphery, cortical cytoskeleton, cytoplasm, cytoskeleton, membrane, plasma membrane
Pathways:
UniProt: P49222
Entrez ID: 13828
|
Does Knockout of Prokr1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Prokr1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Prokr1 (prokineticin receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to hormone stimulus, circadian rhythm, coronary vasculature development, negative regulation of apoptotic process, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled receptor activity, neuropeptide Y receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q9JKL1
Entrez ID: 58182
|
Does Knockout of Mrps18a in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Mrps18a
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Mrps18a (mitochondrial ribosomal protein S18A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q99N85
Entrez ID: 68565
|
Does Knockout of Spast in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Spast
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Spast (spastin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal transport, axonal transport of mitochondrion, axonogenesis, cell differentiation, cell division, central nervous system neuron axonogenesis, cytokinetic process, endoplasmic reticulum to Golgi vesicle-mediated transport, exit from mitosis, membrane fission, microtubule bundle formation, microtubule severing, mitotic cytokinesis, mitotic spindle disassembly, nervous system development, nuclear membrane reassembly, positive regulation of cytokinesis, positive regulation of microtubule depolymerization, protein hexamerization, protein homooligomerization; MF: ATP binding, ATP hydrolysis activity, alpha-tubulin binding, beta-tubulin binding, catalytic activity, isomerase activity, microtubule binding, microtubule severing ATPase activity, nucleotide binding; CC: axon, axon cytoplasm, cell projection, centrosome, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, endosome, lipid droplet, membrane, microtubule, microtubule cytoskeleton, midbody, nuclear membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, spindle, spindle pole
Pathways: Cell Cycle, Cell Cycle, Mitotic, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Nuclear Envelope (NE) Reassembly, Sealing of the nuclear envelope (NE) by ESCRT-III
UniProt: Q9QYY8
Entrez ID: 50850
|
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