prompt
string
hit
int64
screen_id
int64
crispr_strategy
string
gene
string
phenotype
string
cell_type
string
gene_context
string
Does Knockout of Atg7 in Mouse kidney carcinoma cell causally result in cell proliferation?
1
1,288
Knockout
Atg7
cell proliferation
Mouse kidney carcinoma cell
Gene: Atg7 (autophagy related 7) Type: protein-coding Summary: This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has ...
Does Knockout of Nuf2 in Embryonic Stem Cell Line causally result in cell proliferation?
1
579
Knockout
Nuf2
cell proliferation
Embryonic Stem Cell Line
Gene: Nuf2 (NUF2, NDC80 kinetochore complex component) Type: protein-coding Summary: No summary available. Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore organiza...
Does Knockout of Ccdc170 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
81
Knockout
Ccdc170
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Ccdc170 (coiled-coil domain containing 170) Type: protein-coding Summary: Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in cell junction. Predicted to be active in Golgi apparatus. Orthologous to human C...
Does Knockout of Wipf2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
Wipf2
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Wipf2 (WAS/WASL interacting protein family, member 2) Type: protein-coding Summary: Predicted to enable actin binding activity. Predicted to be located in cytoplasm and cytoskeleton. Orthologous to human WIPF2 (WAS/WASL interacting protein family member 2). [provided by Alliance of Genome Resource...
Does Knockout of Mrto4 in Immortal mouse chromaffin cells causally result in cell viability?
1
2,469
Knockout
Mrto4
cell viability
Immortal mouse chromaffin cells
Gene: Mrto4 (mRNA turnover 4, ribosome maturation factor) Type: protein-coding Summary: No summary available. Gene Ontology: BP: nuclear-transcribed mRNA catabolic process, rRNA processing, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis; CC: cytoplasm,...
Does Knockout of Gm973 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
82
Knockout
Gm973
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Gm973 (predicted gene 973) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q6GQX7, E9Q295, A0A1D5RLQ5, A0A087WRV0, A0A087WSM0 Entrez ID: 381260
Does Knockout of Fktn in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,289
Knockout
Fktn
cell proliferation
Mouse kidney carcinoma cell
Gene: Fktn (fukutin) Type: protein-coding Summary: Enables phosphotransferase activity, for other substituted phosphate groups. Acts upstream of or within several processes, including brain development; glycoprotein metabolic process; and skeletal muscle fiber differentiation. Located in Golgi membrane....
Does Knockout of Ube2q2 in Mouse cell causally result in protein/peptide accumulation?
0
1,047
Knockout
Ube2q2
protein/peptide accumulation
Mouse cell
Gene: Ube2q2 (ubiquitin-conjugating enzyme E2Q family member 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein K48-linked ubiquitination, protein ubiquitination; MF: ATP binding, nucleotide binding, transferase activity, ubiquitin conjugating enzyme activity, ubi...
Does Knockout of Plek2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
165
Knockout
Plek2
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Plek2 (pleckstrin 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: actin cytoskeleton organization, intracellular signal transduction, positive regulation of cell projection organization, positive regulation of plasma membrane bounded cell projection assembly; MF:...
Does Knockout of Ptpmt1 in myoblast cell line causally result in protein/peptide distribution?
0
1,679
Knockout
Ptpmt1
protein/peptide distribution
myoblast cell line
Gene: Ptpmt1 (protein tyrosine phosphatase, mitochondrial 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cardiolipin biosynthetic process, lipid metabolic process, negative regulation of insulin secretion involved in cellular response to glucose stimulus, phosphatidyl...
Does Knockout of Mindy2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
Mindy2
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Mindy2 (MINDY lysine 48 deubiquitinase 2) Type: protein-coding Summary: No summary available. Gene Ontology: MF: K11-linked polyubiquitin modification-dependent protein binding, K48-linked deubiquitinase activity, K48-linked polyubiquitin modification-dependent protein binding, K6-linked ...
Does Knockout of Irf5 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Irf5
phagocytosis
macrophage
Gene: Irf5 (interferon regulatory factor 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular response to muramyl dipeptide, cellular response to peptidoglycan, cellular response to virus, cytokine-mediated signaling pathway, defense response to virus, immune syste...
Does Knockout of Syna in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,290
Knockout
Syna
cell proliferation
Mouse kidney carcinoma cell
Gene: Syna (syncytin a) Type: protein-coding Summary: Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a mouse endogenous retrovirus provirus on ...
Does Knockout of Isca1 in myoblast cell line causally result in protein/peptide distribution?
1
1,684
Knockout
Isca1
protein/peptide distribution
myoblast cell line
Gene: Isca1 (iron-sulfur cluster assembly 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: iron-sulfur cluster assembly, protein maturation; MF: 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding; CC: cytoplasm, mitochondrial [4Fe-4S] assem...
Does Knockout of Rin1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
165
Knockout
Rin1
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Rin1 (Ras and Rab interactor 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: associative learning, endocytosis, memory, negative regulation of synaptic plasticity, signal transduction, vesicle-mediated transport; MF: GTPase activator activity, guanyl-nucleotide e...
Does Knockout of Fkrp in Colonic Cancer Cell Line causally result in cell proliferation?
1
1,275
Knockout
Fkrp
cell proliferation
Colonic Cancer Cell Line
Gene: Fkrp (fukutin related protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: adult walking behavior, basement membrane organization, bone mineralization, brain development, camera-type eye development, central nervous system development, connective tissue developm...
Does Knockout of Sdhaf3 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Sdhaf3
protein/peptide accumulation
Embryonic Cell Line
Gene: Sdhaf3 (succinate dehydrogenase complex assembly factor 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: mitochondrial respiratory chain complex II assembly; CC: mitochondrial intermembrane space, mitochondrial matrix, mitochondrion Pathways: Aerobic resp...
Does Knockout of Psmd4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Psmd4
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Psmd4 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 4) Type: protein-coding Summary: No summary available. Gene Ontology: MF: identical protein binding, molecular adaptor activity, polyubiquitin modification-dependent protein binding; CC: cytosol, nucleoplasm, nucleus, proteas...
Does Knockout of Ruvbl1 in Embryonic Cell Line causally result in protein/peptide accumulation?
1
1,152
Knockout
Ruvbl1
protein/peptide accumulation
Embryonic Cell Line
Gene: Ruvbl1 (RuvB-like AAA ATPase 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, box C/D snoRNP assembly, cell division, chromatin organization, chromatin remodeling, positive regulation of DNA repair, positive regu...
Does Knockout of Mtbp in Embryonic Stem Cell Line causally result in cell proliferation?
1
2,477
Knockout
Mtbp
cell proliferation
Embryonic Stem Cell Line
Gene: Mtbp (Mdm2, transformed 3T3 cell double minute p53 binding protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of cell population proliferation, negative regulation of mitotic nuclear division, protein localization to kinetochore, regulation...
Does Knockout of Mir367 in breast epithelium causally result in cell cycle progression?
0
1,468
Knockout
Mir367
cell cycle progression
breast epithelium
Gene: Mir367 (microRNA 367) Type: ncRNA Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I...
Does Knockout of C2cd4a in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
C2cd4a
cell viability
Immortal mouse chromaffin cells
Gene: C2cd4a (C2 calcium-dependent domain containing 4A) Type: protein-coding Summary: No summary available. Gene Ontology: BP: positive regulation of acute inflammatory response, regulation of cell adhesion, regulation of vascular permeability involved in acute inflammatory response; CC: nucle...
Does Knockout of Kmt5a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
83
Knockout
Kmt5a
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Kmt5a (lysine methyltransferase 5A) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell division, chromatin organization, chromatin remodeling, double-strand break repair via homologous recombination, methylation, negative regulation of DNA-templated transcription,...
Does Knockout of Mta3 in myoblast cell line causally result in protein/peptide distribution?
1
1,684
Knockout
Mta3
protein/peptide distribution
myoblast cell line
Gene: Mta3 (metastasis associated 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, po...
Does Knockout of Ccdc12 in Colonic Cancer Cell Line causally result in cell proliferation?
1
1,264
Knockout
Ccdc12
cell proliferation
Colonic Cancer Cell Line
Gene: Ccdc12 (coiled-coil domain containing 12) Type: protein-coding Summary: No summary available. Gene Ontology: CC: U2-type spliceosomal complex, post-mRNA release spliceosomal complex Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus mu...
Does Knockout of Svop in Regulatory T cell causally result in protein/peptide accumulation?
0
1,482
Knockout
Svop
protein/peptide accumulation
Regulatory T cell
Gene: Svop (SV2 related protein) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cytoplasmic vesicle, membrane, synapse, synaptic vesicle, synaptic vesicle membrane Pathways: UniProt: Q8BFT9 Entrez ID: 68666
Does Knockout of Cnbd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,271
Knockout
Cnbd1
cell proliferation
Mouse kidney carcinoma cell
Gene: Cnbd1 (cyclic nucleotide binding domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID: 435772
Does Knockout of Wbp4 in Melanoma Cell Line causally result in cell proliferation?
1
1,270
Knockout
Wbp4
cell proliferation
Melanoma Cell Line
Gene: Wbp4 (WW domain binding protein 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA splicing, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, metal ion binding, nucleic acid binding, proline-rich region bindin...
Does Knockout of Paqr4 in Embryonic Stem Cell Line causally result in cell proliferation?
0
2,477
Knockout
Paqr4
cell proliferation
Embryonic Stem Cell Line
Gene: Paqr4 (progestin and adipoQ receptor family member IV) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein stabilization, regulation of ceramide biosynthetic process; MF: molecular adaptor activity; CC: Golgi apparatus, Golgi membrane, cellular_component, membra...
Does Knockout of Cacfd1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
1,130
Knockout
Cacfd1
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Cacfd1 (calcium channel flower domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cellular_component, membrane, plasma membrane, vesicle Pathways: UniProt: Q8BG21 Entrez ID: 381356
Does Knockout of Terf1 in Embryonic Stem Cell Line causally result in cell proliferation?
1
2,477
Knockout
Terf1
cell proliferation
Embryonic Stem Cell Line
Gene: Terf1 (telomeric repeat binding factor 1) Type: protein-coding Summary: This gene encodes a protein that binds to repeats in telomeres to form a nucleoprotein complex that protects against the degradation of chromosomal ends. The encoded protein regulates the length of telomeres and is an integral...
Does Knockout of Sema5b in myoblast cell line causally result in protein/peptide distribution?
0
1,679
Knockout
Sema5b
protein/peptide distribution
myoblast cell line
Gene: Sema5b (sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: axon extension, axon guidance, cell differentiation, detection of lig...
Does Knockout of Mbd2 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Mbd2
phagocytosis
macrophage
Gene: Mbd2 (methyl-CpG binding domain protein 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cellular response to serotonin, chromatin remodeling, embryonic organ development, epigenetic regulation of g...
Does Knockout of Sult6b1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
81
Knockout
Sult6b1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Sult6b1 (sulfotransferase family, cytosolic, 6B, member 1) Type: protein-coding Summary: No summary available. Gene Ontology: MF: sulfotransferase activity, transferase activity; CC: cytoplasm, cytosol Pathways: Biological oxidations, Cytosolic sulfonation of small molecules, Met...
Does Knockout of Zfp746 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,287
Knockout
Zfp746
cell proliferation
Mouse kidney carcinoma cell
Gene: Zfp746 (zinc finger protein 746) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, protein heteroo...
Does Knockout of Pop5 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
1
2,172
Knockout
Pop5
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Pop5 (processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: ribonuclease MRP activity, ribonuclease P RNA binding, ribonuclease P activity; ...
Does Knockout of Atg2b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
165
Knockout
Atg2b
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Atg2b (autophagy related 2B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: autophagosome assembly, autophagy, autophagy of mitochondrion, glycophagy, intermembrane lipid transfer, lipid transport, pexophagy, piecemeal microautophagy of the nucleus, reticulophagy; ...
Does Knockout of Rnf7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
83
Knockout
Rnf7
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Rnf7 (ring finger protein 7) Type: protein-coding Summary: No summary available. Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, apoptotic mitochondrial changes, cGAS/STING signaling pathway, cerebral cortex radially oriented cell migration, def...
Does Knockout of Ctrb1 in myoblast cell line causally result in protein/peptide distribution?
0
1,684
Knockout
Ctrb1
protein/peptide distribution
myoblast cell line
Gene: Ctrb1 (chymotrypsinogen B1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: digestion, positive regulation of apoptotic process, protein catabolic process, proteolysis, response to cytokine; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activ...
Does Knockout of Klk1b11 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
161
Knockout
Klk1b11
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Klk1b11 (kallikrein 1-related peptidase b11) Type: protein-coding Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasti...
Does Knockout of Pspn in Embryonic Stem Cell Line causally result in cell proliferation?
0
579
Knockout
Pspn
cell proliferation
Embryonic Stem Cell Line
Gene: Pspn (persephin) Type: protein-coding Summary: This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the matu...
Does Knockout of 9330159F19Rik in myoblast cell line causally result in protein/peptide distribution?
1
1,679
Knockout
9330159F19Rik
protein/peptide distribution
myoblast cell line
Gene: 9330159F19Rik (RIKEN cDNA 9330159F19 gene) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: A0A1L1SS16, D3Z623 Entrez ID: 212448
Does Knockout of Cercam in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
165
Knockout
Cercam
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Cercam (cerebral endothelial cell adhesion molecule) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell adhesion; MF: identical protein binding, procollagen galactosyltransferase activity; CC: cellular_component, endoplasmic reticulum, endoplasmic reticulum lumen ...
Does Knockout of Gapdh in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
161
Knockout
Gapdh
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Gapdh (glyceraldehyde-3-phosphate dehydrogenase) Type: protein-coding Summary: This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct funct...
Does Knockout of Pcdh1 in Embryonic Stem Cell Line causally result in cell proliferation?
0
578
Knockout
Pcdh1
cell proliferation
Embryonic Stem Cell Line
Gene: Pcdh1 (protocadherin 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell ad...
Does Knockout of Clstn2 in Pancreatic Cancer Cell Line causally result in response to chemicals?
0
2,359
Knockout
Clstn2
response to chemicals
Pancreatic Cancer Cell Line
Gene: Clstn2 (calsyntenin 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: associative learning, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, inhibitory synapse assembly, positive regulation of synapse assembly, positive regulation of ...
Does Knockout of Scaf11 in breast epithelium causally result in cell cycle progression?
0
1,468
Knockout
Scaf11
cell cycle progression
breast epithelium
Gene: Scaf11 (SR-related CTD-associated factor 11) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, spliceosomal complex assembly; MF: metal ion binding, zinc ion binding; CC: nuclear body, nucleolus, nucleopla...
Does Knockout of Tlk2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
1
2,307
Knockout
Tlk2
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Tlk2 (tousled-like kinase 2 (Arabidopsis)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, cell differentiation, cellular response to gamma radiation, chromatin organization, chromosome segregation, intracellular signal transduction, negative re...
Does Knockout of Adsl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
81
Knockout
Adsl
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Adsl (adenylosuccinate lyase) Type: protein-coding Summary: This gene encodes a protein that is involved in adenosine monophosphate (AMP) biosynthesis and maintaining AMP levels in the muscle. The encoded enzyme catalyzes the release of fumarate during AMP biosynthesis by cleaving the substrates s...
Does Knockout of Mrps18b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
83
Knockout
Mrps18b
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Mrps18b (mitochondrial ribosomal protein S18B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: cell junction, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mit...
Does Knockout of Chaf1b in Colonic Cancer Cell Line causally result in cell proliferation?
1
1,264
Knockout
Chaf1b
cell proliferation
Colonic Cancer Cell Line
Gene: Chaf1b (chromatin assembly factor 1, subunit B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin assembly, chromatin organization, nucleosome assembly; CC: CAF-1 complex, chromatin,...
Does Knockout of Tgfbrap1 in Embryonic Stem Cell Line causally result in cell proliferation?
0
578
Knockout
Tgfbrap1
cell proliferation
Embryonic Stem Cell Line
Gene: Tgfbrap1 (transforming growth factor, beta receptor associated protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: autophagy, endosomal vesicle fusion, endosome to lysosome transport, intracellular protein transport, protein transport, regulation of DNA-templ...
Does Knockout of Sdhb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
161
Knockout
Sdhb
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Sdhb (succinate dehydrogenase complex, subunit B, iron sulfur (Ip)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, respiratory el...
Does Knockout of Dsn1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Dsn1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Dsn1 (DSN1 homolog, MIS12 kinetochore complex component) Type: protein-coding Summary: No summary available. Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, skeletal muscle satellite cell proliferation; CC: MIS12/MIND type compl...
Does Knockout of Sncaip in myoblast cell line causally result in protein/peptide distribution?
0
1,682
Knockout
Sncaip
protein/peptide distribution
myoblast cell line
Gene: Sncaip (synuclein, alpha interacting protein (synphilin)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: dopamine metabolic process, regulation of inclusion body assembly, regulation of neurotransmitter secretion; MF: identical protein binding, ubiquitin protein li...
Does Knockout of Kcnk9 in breast epithelium causally result in cell cycle progression?
0
1,468
Knockout
Kcnk9
cell cycle progression
breast epithelium
Gene: Kcnk9 (potassium channel, subfamily K, member 9) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular response to acidic pH, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of aldosterone secretion, potassium ion import acro...
Does Knockout of Pgrmc2 in Colonic Cancer Cell Line causally result in cell proliferation?
1
1,275
Knockout
Pgrmc2
cell proliferation
Colonic Cancer Cell Line
Gene: Pgrmc2 (progesterone receptor membrane component 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: adipose tissue development, heme transport; MF: heme binding, heme transmembrane transporter activity, lipid binding, protein binding, steroid binding; CC: endomembra...
Does Knockout of Cstf3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
1
1,262
Knockout
Cstf3
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Cstf3 (cleavage stimulation factor, 3' pre-RNA, subunit 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA 3'-end processing, RNA processing, co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA processing...
Does Knockout of Zswim1 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Zswim1
phagocytosis
macrophage
Gene: Zswim1 (zinc finger SWIM-type containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding Pathways: UniProt: Q9CWV7 Entrez ID: 71971
Does Knockout of Polr3f in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
81
Knockout
Polr3f
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Polr3f (polymerase (RNA) III (DNA directed) polypeptide F) Type: protein-coding Summary: No summary available. Gene Ontology: BP: defense response to virus, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta...
Does Knockout of Cdh24 in myoblast cell line causally result in protein/peptide distribution?
1
1,681
Knockout
Cdh24
protein/peptide distribution
myoblast cell line
Gene: Cdh24 (cadherin-like 24) Type: protein-coding Summary: No summary available. Gene Ontology: BP: adherens junction organization, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cel...
Does Knockout of Ciapin1 in Embryonic Stem Cell Line causally result in cell proliferation?
0
2,477
Knockout
Ciapin1
cell proliferation
Embryonic Stem Cell Line
Gene: Ciapin1 (cytokine induced apoptosis inhibitor 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic process, hemopoiesis, iron-sulfur cluster assembly, negative regulation of apoptotic process; MF: 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster bi...
Does Knockout of Emc4 in Embryonic Fibroblast Cell Line causally result in response to virus?
1
1,133
Knockout
Emc4
response to virus
Embryonic Fibroblast Cell Line
Gene: Emc4 (ER membrane protein complex subunit 4) Type: protein-coding Summary: Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane....
Does Knockout of Aasdhppt in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Aasdhppt
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Aasdhppt (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: 10-formyltetrahydrofolate catabolic process, lysine biosynthetic process via aminoadipic acid, protein maturation; MF: holo-[acyl-carri...
Does Knockout of Sgk1 in Regulatory T cell causally result in protein/peptide accumulation?
0
1,482
Knockout
Sgk1
protein/peptide accumulation
Regulatory T cell
Gene: Sgk1 (serum/glucocorticoid regulated kinase 1) Type: protein-coding Summary: This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regula...
Does Knockout of Adgrg2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,287
Knockout
Adgrg2
cell proliferation
Mouse kidney carcinoma cell
Gene: Adgrg2 (adhesion G protein-coupled receptor G2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, phosphol...
Does Knockout of Mrgprb2 in myoblast cell line causally result in protein/peptide distribution?
1
1,684
Knockout
Mrgprb2
protein/peptide distribution
myoblast cell line
Gene: Mrgprb2 (MAS-related GPR, member B2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, mast cell activation, mast cell degranulation, positive regulation of chemokine production, positive regulation of cytokine production,...
Does Knockout of Adcy1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,174
Knockout
Adcy1
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Adcy1 (adenylate cyclase 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: adenylate cyclase-activating G protein-coupled receptor signaling pathway, axonogenesis, cAMP biosynthetic process, cellular response to calcium ion, cellular response to forskolin, cyclic n...
Does Knockout of Syt2 in Melanoma Cell Line causally result in cell proliferation?
0
2,492
Knockout
Syt2
cell proliferation
Melanoma Cell Line
Gene: Syt2 (synaptotagmin II) Type: protein-coding Summary: This gene encodes a member of the synaptotagmin protein family. Synaptotagmin proteins are involved in membrane trafficking and are characterized by an N-terminal transmembrane region as well as tandem calcium binding domains. The encoded prote...
Does Knockout of Igll1 in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
Igll1
cell viability
Immortal mouse chromaffin cells
Gene: Igll1 (immunoglobulin lambda-like polypeptide 1) Type: protein-coding Summary: No summary available. Gene Ontology: MF: antigen binding, protein binding; CC: IgG immunoglobulin complex, endoplasmic reticulum, extracellular region Pathways: Adaptive Immune System, Antigen activate...
Does Knockout of Csf3 in Melanoma Cell Line causally result in cell proliferation?
0
1,270
Knockout
Csf3
cell proliferation
Melanoma Cell Line
Gene: Csf3 (colony stimulating factor 3 (granulocyte)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular response to cytokine stimulus, granulocyte colony-stimulating factor signaling pathway, granulocyte differentiation, immune response, positive regulation of act...
Does Knockout of Fzr1 in Lymphoma Cell Line causally result in response to chemicals?
1
1,530
Knockout
Fzr1
response to chemicals
Lymphoma Cell Line
Gene: Fzr1 (fizzy and cell division cycle 20 related 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, DNA synthesis involved in mitotic DNA replication, anaphase-promoting complex-dependent catabolic process, cell division, lens fiber ce...
Does Knockout of Ppp1r7 in Melanoma Cell Line causally result in cell proliferation?
1
1,270
Knockout
Ppp1r7
cell proliferation
Melanoma Cell Line
Gene: Ppp1r7 (protein phosphatase 1, regulatory subunit 7) Type: protein-coding Summary: No summary available. Gene Ontology: MF: protein binding, protein phosphatase regulator activity; CC: chromosome, nucleus Pathways: UniProt: Q3UM45 Entrez ID: 66385
Does Knockout of Vmn1r237 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
161
Knockout
Vmn1r237
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Vmn1r237 (vomeronasal 1 receptor 237) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromon...
Does Knockout of Rab29 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
161
Knockout
Rab29
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Rab29 (RAB29, member RAS oncogene family) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Golgi organization, T cell activation, cell differentiation, cellular detoxification, cilium assembly, host-mediated perturbation of viral process, intracellular protein transp...
Does Knockout of Nelfa in Microglial Cell Line causally result in protein/peptide distribution?
1
1,585
Knockout
Nelfa
protein/peptide distribution
Microglial Cell Line
Gene: Nelfa (negative elongation factor complex member A, Whsc2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of transcription elongation by RNA polymerase II, positive regulation of transcription by RNA polymerase II; MF: chromatin binding, molecul...
Does Knockout of Rrp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
81
Knockout
Rrp1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Rrp1 (ribosomal RNA processing 1) Type: protein-coding Summary: No summary available. Gene Ontology: CC: chromosome, nucleolus, nucleus, preribosome, small subunit precursor Pathways: UniProt: P56183 Entrez ID: 18114
Does Knockout of Pop1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
1
684
Knockout
Pop1
cell proliferation
Acute Myeloid Leukemia Cell Line
Gene: Pop1 (processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: tRNA 5'-leader removal, tRNA decay, tRNA processing; MF: ribonuclease P RNA binding, ribonuclease P activity; CC: multimeric ribonuclease P c...
Does Knockout of Abt1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
1
1,267
Knockout
Abt1
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Abt1 (activator of basal transcription 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU...
Does Knockout of Cks1brt in Mouse cell causally result in protein/peptide accumulation?
0
1,047
Knockout
Cks1brt
protein/peptide accumulation
Mouse cell
Gene: Cks1brt (CDC28 protein kinase 1b, retrogene) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell division, fibroblast proliferation, mitotic cell cycle phase transition, regulation of mitotic cell cycle; MF: cyclin-dependent protein serine/threonine kinase activato...
Does Knockout of Nyx in myoblast cell line causally result in protein/peptide distribution?
0
1,681
Knockout
Nyx
protein/peptide distribution
myoblast cell line
Gene: Nyx (nyctalopin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: visual perception; MF: protein binding, signaling receptor activity; CC: dendrite, extracellular matrix, extracellular region, postsynapse Pathways: UniProt: P83503 Entrez ID...
Does Knockout of Nmnat3 in myoblast cell line causally result in protein/peptide distribution?
1
1,684
Knockout
Nmnat3
protein/peptide distribution
myoblast cell line
Gene: Nmnat3 (nicotinamide nucleotide adenylyltransferase 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: NAD+ biosynthetic process, NAD+ biosynthetic process via the salvage pathway, nicotinamide metabolic process, nucleotide biosynthetic process, pyridine nucleotide ...
Does Knockout of Osbpl11 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
1
1,522
Knockout
Osbpl11
protein/peptide accumulation
Embryonic Fibroblast Cell Line
Gene: Osbpl11 (oxysterol binding protein-like 11) Type: protein-coding Summary: No summary available. Gene Ontology: BP: fat cell differentiation, lipid transport, triglyceride homeostasis; MF: lipid binding, sterol binding; CC: Golgi apparatus, cytosol, endosome, late endosome membrane, membra...
Does Knockout of Tbx18 in Embryonic Cell Line causally result in protein/peptide accumulation?
1
1,440
Knockout
Tbx18
protein/peptide accumulation
Embryonic Cell Line
Gene: Tbx18 (T-box18) Type: protein-coding Summary: No summary available. Gene Ontology: BP: anatomical structure formation involved in morphogenesis, anterior/posterior axis specification, cell differentiation, cell fate specification, cochlea morphogenesis, morphogenesis of embryonic epitheli...
Does Knockout of Ubtd2 in Melanoma Cell Line causally result in cell proliferation?
1
2,492
Knockout
Ubtd2
cell proliferation
Melanoma Cell Line
Gene: Ubtd2 (ubiquitin domain containing 2) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q6PGH0 Entrez ID: 327900
Does Knockout of Spdl1 in Embryonic Stem Cell Line causally result in cell proliferation?
1
579
Knockout
Spdl1
cell proliferation
Embryonic Stem Cell Line
Gene: Spdl1 (spindle apparatus coiled-coil protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell division, cell migration, establishment of mitotic spindle orientation, mitotic metaphase chromosome alignment, mitotic spindle assembly checkpoint signaling, protei...
Does Knockout of Rpl13 in Embryonic Stem Cell Line causally result in cell proliferation?
1
578
Knockout
Rpl13
cell proliferation
Embryonic Stem Cell Line
Gene: Rpl13 (ribosomal protein L13) Type: protein-coding Summary: No summary available. Gene Ontology: BP: blastocyst development, bone development, cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome; ...
Does Knockout of Mtbp in Microglial Cell Line causally result in protein/peptide distribution?
0
1,585
Knockout
Mtbp
protein/peptide distribution
Microglial Cell Line
Gene: Mtbp (Mdm2, transformed 3T3 cell double minute p53 binding protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of cell population proliferation, negative regulation of mitotic nuclear division, protein localization to kinetochore, regulation...
Does Knockout of Rassf8 in Embryonic Fibroblast Cell Line causally result in autophagy?
1
1,043
Knockout
Rassf8
autophagy
Embryonic Fibroblast Cell Line
Gene: Rassf8 (Ras association (RalGDS/AF-6) domain family (N-terminal) member 8) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q8CJ96 Entrez ID: 71323
Does Knockout of Fbl in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,275
Knockout
Fbl
cell proliferation
Colonic Cancer Cell Line
Gene: Fbl (fibrillarin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: box C/D sno(s)RNA 3'-end processing, chromatin remodeling, methylation, rRNA methylation, rRNA processing, ribosomal small subunit biogenesis, sno(s)RNA metabolic process, snoRNA localization; MF: ATP...
Does Knockout of Ctcf in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
1
684
Knockout
Ctcf
cell proliferation
Acute Myeloid Leukemia Cell Line
Gene: Ctcf (CCCTC-binding factor) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cardiac muscle cell development, cardiac muscle cell differentiation, chromatin looping, chromatin organization, chromosome ...
Does Knockout of Pdxk in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
83
Knockout
Pdxk
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Pdxk (pyridoxal (pyridoxine, vitamin B6) kinase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: pyridoxal 5'-phosphate salvage, pyridoxal metabolic process, pyridoxal phosphate metabolic process, pyridoxamine metabolic process, pyridoxine metabolic process; MF: ATP...
Does Knockout of Abraxas1 in Microglial Cell Line causally result in response to virus?
0
1,438
Knockout
Abraxas1
response to virus
Microglial Cell Line
Gene: Abraxas1 (BRCA1 A complex subunit) Type: protein-coding Summary: Predicted to enable microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; nuclear chromoso...
Does Knockout of Ppa1 in Melanoma Cell Line causally result in cell proliferation?
0
2,492
Knockout
Ppa1
cell proliferation
Melanoma Cell Line
Gene: Ppa1 (pyrophosphatase (inorganic) 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: phosphate-containing compound metabolic process; MF: hydrolase activity, inorganic diphosphate phosphatase activity, magnesium ion binding, metal ion binding, pyrophosphatase activi...
Does Knockout of Pon3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,280
Knockout
Pon3
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Pon3 (paraoxonase 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: carboxylic acid catabolic process, coumarin catabolic process, establishment of localization in cell, lactone catabolic process, negative regulation of superoxide anion generation, phenylacetate ca...
Does Knockout of Mccc2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,273
Knockout
Mccc2
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Mccc2 (methylcrotonoyl-Coenzyme A carboxylase 2 (beta)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: L-leucine catabolic process, coenzyme A metabolic process; MF: ATP binding, ligase activity, methylcrotonoyl-CoA carboxylase activity, nucleotide binding; CC: met...
Does Knockout of Npat in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
1
1,262
Knockout
Npat
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Npat (nuclear protein in the AT region) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell cycle G1/S phase transition, in utero embryonic development, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive...
Does Knockout of Lipt2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
1
2,171
Knockout
Lipt2
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Lipt2 (lipoyl(octanoyl) transferase 2 (putative)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: positive regulation of oxygen metabolic process, protein lipoylation; MF: acyltransferase activity, ligase activity, lipoyl(octanoyl) transferase activity, protein bind...
Does Knockout of 4930544D05Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
81
Knockout
4930544D05Rik
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: 4930544D05Rik (RIKEN cDNA 4930544D05 gene) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: J3QJW4, J3QK56, J3KMM3 Entrez ID: 668433
Does Knockout of Cers3 in Embryonic Fibroblast Cell Line causally result in response to virus?
0
1,133
Knockout
Cers3
response to virus
Embryonic Fibroblast Cell Line
Gene: Cers3 (ceramide synthase 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ceramide biosynthetic process, cornification, epidermis development, keratinocyte differentiation, lipid metabolic process, sphingolipid biosynthetic process, sphingolipid metabolic process;...