prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Atg7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,288
|
Knockout
|
Atg7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atg7 (autophagy related 7)
Type: protein-coding
Summary: This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: adult walking behavior, autophagosome assembly, autophagy, autophagy of mitochondrion, cardiac muscle cell development, cell population proliferation, cellular response to hyperoxia, cellular response to nitrogen starvation, cellular response to reactive oxygen species, cellular response to sodium arsenite, cellular response to starvation, cellular response to stress, central nervous system neuron axonogenesis, cerebellar Purkinje cell layer development, cerebral cortex development, chaperone-mediated autophagy, chromatin organization, defense response to virus, dendrite arborization, establishment of localization in cell, innate immune response, intracellular amino acid homeostasis, intracellular sphingolipid homeostasis, liver development, macroautophagy, membrane organization, mitochondrion organization, mitophagy, negative regulation of apoptotic process, negative regulation of cardiac muscle cell apoptotic process, negative regulation of dendrite extension, negative regulation of mitochondrial DNA replication, negative regulation of neuron apoptotic process, negative regulation of phagocytosis, negative regulation of programmed necrotic cell death, negative regulation of sphingolipid biosynthetic process, negative regulation of type B pancreatic cell apoptotic process, negative stranded viral RNA replication, nervous system process, neuron projection development, piecemeal microautophagy of the nucleus, positive regulation of apoptotic process, positive regulation of autophagosome assembly, positive regulation of autophagy, positive regulation of catabolic process, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of mitophagy, positive regulation of mucus secretion, positive regulation of programmed cell death, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein catabolic process, post-embryonic development, protein catabolic process, protein modification by small protein conjugation, protein transport, pyramidal neuron development, regulation of cell development, regulation of circadian rhythm, regulation of hemopoiesis, regulation of macromolecule metabolic process, regulation of primary metabolic process, regulation of protein ubiquitination, response to nutrient levels, response to starvation, rhythmic process, synaptic vesicle cycle; MF: Atg12 activating enzyme activity, Atg8 activating enzyme activity, protein binding, protein homodimerization activity, ubiquitin-like modifier activating enzyme activity; CC: axon, axoneme, cytoplasm, cytosol, dopaminergic synapse, membrane, perinuclear region of cytoplasm, phagophore assembly site, presynapse
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, Ferroptosis - Mus musculus (mouse), Immune System, Innate Immune System, Macroautophagy, Neutrophil degranulation, Neutrophil extracellular trap formation - Mus musculus (mouse)
UniProt: Q9D906
Entrez ID: 74244
|
Does Knockout of Nuf2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Nuf2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nuf2 (NUF2, NDC80 kinetochore complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore organization, meiotic chromosome segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization; MF: microtubule binding, protein-containing complex binding; CC: Ndc80 complex, chromosome, chromosome, centromeric region, cytosol, kinetochore, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q99P69
Entrez ID: 66977
|
Does Knockout of Ccdc170 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Ccdc170
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ccdc170 (coiled-coil domain containing 170)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in cell junction. Predicted to be active in Golgi apparatus. Orthologous to human CCDC170 (coiled-coil domain containing 170). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: microtubule cytoskeleton organization; MF: microtubule binding; CC: Golgi apparatus, cell junction, ciliary basal body
Pathways:
UniProt: F6ST92, D3YXL0, D3Z4M1
Entrez ID: 100504234
|
Does Knockout of Wipf2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Wipf2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Wipf2 (WAS/WASL interacting protein family, member 2)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Predicted to be located in cytoplasm and cytoskeleton. Orthologous to human WIPF2 (WAS/WASL interacting protein family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cytoplasm, cytoskeleton
Pathways: Endocytosis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: Q6PEV3
Entrez ID: 68524
|
Does Knockout of Mrto4 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Mrto4
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Mrto4 (mRNA turnover 4, ribosome maturation factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear-transcribed mRNA catabolic process, rRNA processing, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis; CC: cytoplasm, nucleolus, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q9D0I8
Entrez ID: 69902
|
Does Knockout of Gm973 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Gm973
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gm973 (predicted gene 973)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6GQX7, E9Q295, A0A1D5RLQ5, A0A087WRV0, A0A087WSM0
Entrez ID: 381260
|
Does Knockout of Fktn in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Fktn
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fktn (fukutin)
Type: protein-coding
Summary: Enables phosphotransferase activity, for other substituted phosphate groups. Acts upstream of or within several processes, including brain development; glycoprotein metabolic process; and skeletal muscle fiber differentiation. Located in Golgi membrane. Is expressed in several structures, including central nervous system; future brain; genitourinary system; sensory organ; and spinal ganglion. Used to study Fukuyama congenital muscular dystrophy and muscular dystrophy-dystroglycanopathy type B1. Human ortholog(s) of this gene implicated in dilated cardiomyopathy (multiple) and muscular dystrophy (multiple). Orthologous to human FKTN (fukutin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: basement membrane organization, brain development, cerebellar cortex development, cerebral cortex development, glycoprotein metabolic process, negative regulation of JNK cascade, negative regulation of cell population proliferation, neuron migration, protein O-linked glycosylation, protein O-linked glycosylation via mannose, protein glycosylation, skeletal muscle fiber differentiation; MF: phosphotransferase activity, for other substituted phosphate groups, transferase activity; CC: Golgi apparatus, Golgi membrane, cis-Golgi network, cytoplasm, endoplasmic reticulum, membrane, nucleus
Pathways: DAG1 glycosylations, Mannose type O-glycan biosynthesis - Mus musculus (mouse), Matriglycan biosynthesis on DAG1, Metabolism of proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8R507
Entrez ID: 246179
|
Does Knockout of Ube2q2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Ube2q2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Ube2q2 (ubiquitin-conjugating enzyme E2Q family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein K48-linked ubiquitination, protein ubiquitination; MF: ATP binding, nucleotide binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity; CC: cytoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8K2Z8
Entrez ID: 109161
|
Does Knockout of Plek2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Plek2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Plek2 (pleckstrin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, intracellular signal transduction, positive regulation of cell projection organization, positive regulation of plasma membrane bounded cell projection assembly; MF: phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding; CC: cell projection, cytoplasm, cytoskeleton, lamellipodium membrane, membrane, plasma membrane
Pathways:
UniProt: Q9WV52
Entrez ID: 27260
|
Does Knockout of Ptpmt1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Ptpmt1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ptpmt1 (protein tyrosine phosphatase, mitochondrial 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiolipin biosynthetic process, lipid metabolic process, negative regulation of insulin secretion involved in cellular response to glucose stimulus, phosphatidylglycerol biosynthetic process, phosphatidylinositol metabolic process, phospholipid biosynthetic process, regulation of intrinsic apoptotic signaling pathway; MF: hydrolase activity, phosphatidylglycerophosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-5-phosphate phosphatase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity; CC: cytoplasm, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q66GT5
Entrez ID: 66461
|
Does Knockout of Mindy2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Mindy2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Mindy2 (MINDY lysine 48 deubiquitinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: K11-linked polyubiquitin modification-dependent protein binding, K48-linked deubiquitinase activity, K48-linked polyubiquitin modification-dependent protein binding, K6-linked polyubiquitin modification-dependent protein binding, K63-linked polyubiquitin modification-dependent protein binding, cysteine-type carboxypeptidase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: cell periphery, nucleoplasm
Pathways:
UniProt: Q6PDI6
Entrez ID: 235461
|
Does Knockout of Irf5 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Irf5
|
phagocytosis
|
macrophage
|
Gene: Irf5 (interferon regulatory factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to muramyl dipeptide, cellular response to peptidoglycan, cellular response to virus, cytokine-mediated signaling pathway, defense response to virus, immune system process, inflammatory response, innate immune response, nucleotide-binding oligomerization domain containing 2 signaling pathway, positive regulation of apoptotic process, positive regulation of cytokine production involved in immune response, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of interleukin-12 production, positive regulation of transcription by RNA polymerase II, positive regulation of type I interferon production, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein binding, protein kinase binding, protein serine/threonine kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: cytoplasm, nucleus
Pathways: Immune System, Innate Immune System, SLC15A4:TASL-dependent IRF5 activation, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse)
UniProt: P56477
Entrez ID: 27056
|
Does Knockout of Syna in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Syna
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Syna (syncytin a)
Type: protein-coding
Summary: Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a mouse endogenous retrovirus provirus on chromosome 5 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: labyrinthine layer development, myoblast fusion, syncytium formation, syncytium formation by plasma membrane fusion; CC: membrane, plasma membrane
Pathways:
UniProt: Q5G5D5
Entrez ID: 214292
|
Does Knockout of Isca1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Isca1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Isca1 (iron-sulfur cluster assembly 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: iron-sulfur cluster assembly, protein maturation; MF: 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding; CC: cytoplasm, mitochondrial [4Fe-4S] assembly complex, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis
UniProt: Q9D924
Entrez ID: 69046
|
Does Knockout of Rin1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Rin1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rin1 (Ras and Rab interactor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: associative learning, endocytosis, memory, negative regulation of synaptic plasticity, signal transduction, vesicle-mediated transport; MF: GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding, small GTPase binding; CC: cytoplasm, cytoskeleton, cytosol, dendrite, endocytic vesicle, membrane, neuronal cell body, plasma membrane
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Ras signaling pathway - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q921Q7
Entrez ID: 225870
|
Does Knockout of Fkrp in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Fkrp
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Fkrp (fukutin related protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult walking behavior, basement membrane organization, bone mineralization, brain development, camera-type eye development, central nervous system development, connective tissue development, connective tissue replacement, creatine metabolic process, diaphragm development, extracellular matrix organization, eye development, filtration diaphragm assembly, gene expression, glial cell differentiation, glycolytic process, glycoprotein biosynthetic process, glycoprotein metabolic process, heart development, heart morphogenesis, in utero embryonic development, inflammatory response, intracellular protein localization, lipid metabolic process, localization of cell, maintenance of protein localization in endoplasmic reticulum, muscle cell differentiation, muscle contraction, muscle structure development, neuromuscular process, neuron migration, oxygen metabolic process, pentitol metabolic process, pentose metabolic process, phosphatidylinositol 3-kinase/protein kinase B signal transduction, protein O-linked glycosylation via mannose, protein glycosylation, protein import, protein processing, protein tetramerization, reelin-mediated signaling pathway, respiratory system process, response to activity, response to alcohol, response to glucocorticoid, response to xenobiotic stimulus, skeletal muscle fiber differentiation, skeletal muscle organ development, skeletal muscle tissue development, skeletal muscle tissue regeneration, striated muscle cell differentiation; MF: dystroglycan binding, identical protein binding, laminin binding, metal ion binding, phosphotransferase activity, for other substituted phosphate groups, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endoplasmic reticulum, extracellular region, extracellular space, membrane, nucleoplasm, plasma membrane, rough endoplasmic reticulum, sarcolemma, skeletal muscle myofibril
Pathways: DAG1 glycosylations, Mannose type O-glycan biosynthesis - Mus musculus (mouse), Matriglycan biosynthesis on DAG1, Metabolism of proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8CG64
Entrez ID: 243853
|
Does Knockout of Sdhaf3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Sdhaf3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sdhaf3 (succinate dehydrogenase complex assembly factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex II assembly; CC: mitochondrial intermembrane space, mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism
UniProt: Q8BQU3
Entrez ID: 71238
|
Does Knockout of Psmd4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Psmd4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Psmd4 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular adaptor activity, polyubiquitin modification-dependent protein binding; CC: cytosol, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism of proteins, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, Spinocerebellar ataxia - Mus musculus (mouse), Targeted protein degradation
UniProt: O35226
Entrez ID: 19185
|
Does Knockout of Ruvbl1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Ruvbl1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ruvbl1 (RuvB-like AAA ATPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, box C/D snoRNP assembly, cell division, chromatin organization, chromatin remodeling, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of canonical Wnt signaling pathway, positive regulation of double-strand break repair via homologous recombination, positive regulation of telomere maintenance in response to DNA damage, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of chromosome organization, regulation of double-strand break repair, regulation of embryonic development, regulation of transcription by RNA polymerase II, telomere maintenance; MF: 3'-5' DNA helicase activity, ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATPase binding, DNA helicase activity, TBP-class protein binding, TFIID-class transcription factor complex binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, transcription coactivator activity; CC: Ino80 complex, MLL1 complex, NuA4 histone acetyltransferase complex, R2TP complex, RPAP3/R2TP/prefoldin-like complex, Swr1 complex, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, dynein axonemal particle, membrane, nuclear matrix, nuclear speck, nucleoplasm, nucleosome, nucleus, protein folding chaperone complex, protein-containing complex, ribonucleoprotein complex
Pathways: Cell Cycle, Chromosome Maintenance, DNA Damage Recognition in GG-NER, DNA Repair, Deposition of new CENPA-containing nucleosomes at the centromere, Deubiquitination, Formation of the beta-catenin:TCF transactivating complex, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleosome assembly, Nucleotide Excision Repair, Post-translational protein modification, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, UCH proteinases, Ub-specific processing proteases, Wnt signaling pathway - Mus musculus (mouse)
UniProt: P60122
Entrez ID: 56505
|
Does Knockout of Mtbp in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Mtbp
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mtbp (Mdm2, transformed 3T3 cell double minute p53 binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell population proliferation, negative regulation of mitotic nuclear division, protein localization to kinetochore, regulation of cell cycle, regulation of protein ubiquitination, traversing start control point of mitotic cell cycle; CC: chromatin, kinetochore
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Degradation of CDH1, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q8BJS8
Entrez ID: 105837
|
Does Knockout of Mir367 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Mir367
|
cell cycle progression
|
breast epithelium
|
Gene: Mir367 (microRNA 367)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, lung development, miRNA-mediated post-transcriptional gene silencing
Pathways:
UniProt:
Entrez ID: 723911
|
Does Knockout of C2cd4a in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
C2cd4a
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: C2cd4a (C2 calcium-dependent domain containing 4A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of acute inflammatory response, regulation of cell adhesion, regulation of vascular permeability involved in acute inflammatory response; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: E9Q861
Entrez ID: 244911
|
Does Knockout of Kmt5a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Kmt5a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kmt5a (lysine methyltransferase 5A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, chromatin organization, chromatin remodeling, double-strand break repair via homologous recombination, methylation, negative regulation of DNA-templated transcription, negative regulation of double-strand break repair via homologous recombination, negative regulation of transcription by RNA polymerase II, peptidyl-lysine monomethylation, protein localization to chromatin, regulation of DNA damage response, signal transduction by p53 class mediator, regulation of transcription by RNA polymerase II, replication fork processing; MF: histone H4K20 methyltransferase activity, histone H4K20 monomethyltransferase activity, histone methyltransferase activity, methyltransferase activity, protein binding, protein-lysine N-methyltransferase activity, transcription corepressor activity, transferase activity; CC: chromatin, chromosome, cytosol, nucleoplasm, nucleus, polytene chromosome
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, Lysine degradation - Mus musculus (mouse), Negative Regulation of CDH1 Gene Transcription, PKMTs methylate histone lysines, RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Transcriptional Regulation by TP53
UniProt: Q2YDW7
Entrez ID: 67956
|
Does Knockout of Mta3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Mta3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mta3 (metastasis associated 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of granulosa cell proliferation, regulation of DNA-templated transcription, regulation of cell fate specification, regulation of stem cell differentiation; MF: DNA binding, chromatin binding, histone deacetylase binding, metal ion binding, protein binding, protein-containing complex binding, sequence-specific DNA binding, transcription coactivator activity, transcription corepressor activity, zinc ion binding; CC: NuRD complex, cytoplasm, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), HDACs deacetylate histones, Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, Regulation of PTEN gene transcription, Signal Transduction
UniProt: Q924K8
Entrez ID: 116871
|
Does Knockout of Ccdc12 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Ccdc12
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ccdc12 (coiled-coil domain containing 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: U2-type spliceosomal complex, post-mRNA release spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8R344
Entrez ID: 72654
|
Does Knockout of Svop in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Svop
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Svop (SV2 related protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasmic vesicle, membrane, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways:
UniProt: Q8BFT9
Entrez ID: 68666
|
Does Knockout of Cnbd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Cnbd1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cnbd1 (cyclic nucleotide binding domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 435772
|
Does Knockout of Wbp4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Wbp4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Wbp4 (WW domain binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, metal ion binding, nucleic acid binding, proline-rich region binding, protein binding, zinc ion binding; CC: U2-type precatalytic spliceosome, nuclear speck, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q61048
Entrez ID: 22380
|
Does Knockout of Paqr4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Paqr4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Paqr4 (progestin and adipoQ receptor family member IV)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein stabilization, regulation of ceramide biosynthetic process; MF: molecular adaptor activity; CC: Golgi apparatus, Golgi membrane, cellular_component, membrane
Pathways:
UniProt: Q9JJE4
Entrez ID: 76498
|
Does Knockout of Cacfd1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Cacfd1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cacfd1 (calcium channel flower domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane, plasma membrane, vesicle
Pathways:
UniProt: Q8BG21
Entrez ID: 381356
|
Does Knockout of Terf1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Terf1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Terf1 (telomeric repeat binding factor 1)
Type: protein-coding
Summary: This gene encodes a protein that binds to repeats in telomeres to form a nucleoprotein complex that protects against the degradation of chromosomal ends. The encoded protein regulates the length of telomeres and is an integral structural component of the functional telomere. This protein is thought to play a role in spindle formation in mitosis. Mutations in this gene are associated with bone marrow failure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013].
Gene Ontology: BP: cell division, chromosome organization, meiotic telomere clustering, negative regulation of DNA replication, negative regulation of establishment of RNA localization to telomere, negative regulation of establishment of protein localization to telomere, negative regulation of telomere maintenance via telomerase, negative regulation of telomeric D-loop disassembly, positive regulation of shelterin complex assembly, positive regulation of telomere maintenance, telomere capping, telomere maintenance, telomere maintenance via telomerase, telomeric D-loop disassembly, telomeric loop formation; MF: DNA binding, DNA binding, bending, G-rich strand telomeric DNA binding, ankyrin repeat binding, double-stranded telomeric DNA binding, identical protein binding, microtubule binding, protein binding, protein homodimerization activity, telomerase activity, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, cytoplasm, cytoskeleton, fibrillar center, nuclear body, nuclear telomere cap complex, nucleolus, nucleoplasm, nucleus, shelterin complex, spindle
Pathways: Base Excision Repair, Base-Excision Repair, AP Site Formation, Cell Cycle, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromosome Maintenance, Cleavage of the damaged purine, DNA Damage/Telomere Stress Induced Senescence, DNA Repair, Depurination, Extension of Telomeres, Inhibition of DNA recombination at telomere, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Recognition and association of DNA glycosylase with site containing an affected purine, Removal of the Flap Intermediate from the C-strand, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Extension By Telomerase, Telomere Maintenance
UniProt: P70371
Entrez ID: 21749
|
Does Knockout of Sema5b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Sema5b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sema5b (sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon extension, axon guidance, cell differentiation, detection of light stimulus involved in visual perception, negative chemotaxis, nervous system development, neural crest cell migration, neuron projection extension, neuron projection guidance, positive regulation of cell migration, semaphorin-plexin signaling pathway; MF: chemorepellent activity, semaphorin receptor binding; CC: membrane, plasma membrane
Pathways: Axon guidance - Mus musculus (mouse), Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q60519
Entrez ID: 20357
|
Does Knockout of Mbd2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Mbd2
|
phagocytosis
|
macrophage
|
Gene: Mbd2 (methyl-CpG binding domain protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cellular response to serotonin, chromatin remodeling, embryonic organ development, epigenetic regulation of gene expression, maternal behavior, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of Wnt signaling pathway, protein-containing complex assembly, regulation of cell population proliferation, regulation of transcription by RNA polymerase II, response to bisphenol A, response to estradiol, response to mechanical stimulus, response to nutrient levels, ventricular cardiac muscle tissue development; MF: C2H2 zinc finger domain binding, DNA binding, chromatin binding, identical protein binding, mRNA binding, methyl-CpG binding, molecular adaptor activity, protein binding, protein domain specific binding, siRNA binding; CC: NuRD complex, chromatin, chromosome, cytoplasm, cytosol, heterochromatin, histone deacetylase complex, nucleoplasm, nucleus
Pathways:
UniProt: Q9Z2E1
Entrez ID: 17191
|
Does Knockout of Sult6b1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Sult6b1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sult6b1 (sulfotransferase family, cytosolic, 6B, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: sulfotransferase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Biological oxidations, Cytosolic sulfonation of small molecules, Metabolism, Phase II - Conjugation of compounds
UniProt: P0CC03
Entrez ID: 73671
|
Does Knockout of Zfp746 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Zfp746
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp746 (zinc finger protein 746)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, protein heterooligomerization, protein homooligomerization, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, transcription cis-regulatory region binding, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q3U133
Entrez ID: 69228
|
Does Knockout of Pop5 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Pop5
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pop5 (processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: ribonuclease MRP activity, ribonuclease P RNA binding, ribonuclease P activity; CC: multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonuclease MRP complex, ribonuclease P complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9DB28
Entrez ID: 117109
|
Does Knockout of Atg2b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Atg2b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Atg2b (autophagy related 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, autophagy of mitochondrion, glycophagy, intermembrane lipid transfer, lipid transport, pexophagy, piecemeal microautophagy of the nucleus, reticulophagy; MF: lipid transfer activity, phosphatidylinositol-3-phosphate binding, protein binding, protein-membrane adaptor activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane, phagophore, phagophore assembly site, phagophore assembly site membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q80XK6
Entrez ID: 76559
|
Does Knockout of Rnf7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Rnf7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rnf7 (ring finger protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, apoptotic mitochondrial changes, cGAS/STING signaling pathway, cerebral cortex radially oriented cell migration, defense response to virus, endoplasmic reticulum unfolded protein response, epithelial to mesenchymal transition, erythropoietin-mediated signaling pathway, growth hormone receptor signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, innate immune response, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to oxidative stress, negative regulation of apoptotic process, negative regulation of focal adhesion assembly, negative regulation of growth hormone receptor signaling pathway, phosphocreatine biosynthetic process, positive regulation of focal adhesion assembly, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein neddylation, protein ubiquitination, radial glia guided migration of Purkinje cell, reelin-mediated signaling pathway, regulation of neuron migration, ubiquitin-dependent protein catabolic process; MF: NEDD8 ligase activity, cullin family protein binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: Cul5-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of CSF3 (G-CSF) signaling, Metabolism of proteins, Neddylation, Post-translational protein modification, Signaling by CSF3 (G-CSF), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9WTZ1
Entrez ID: 19823
|
Does Knockout of Ctrb1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Ctrb1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ctrb1 (chymotrypsinogen B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: digestion, positive regulation of apoptotic process, protein catabolic process, proteolysis, response to cytokine; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity
Pathways: Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q9CR35
Entrez ID: 66473
|
Does Knockout of Klk1b11 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Klk1b11
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Klk1b11 (kallikrein 1-related peptidase b11)
Type: protein-coding
Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: proteolysis, regulation of systemic arterial blood pressure, zymogen activation; MF: endopeptidase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: acrosomal vesicle, apical part of cell, extracellular space, nucleus, protein-containing complex, secretory granule
Pathways: Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Extracellular matrix organization, Renin-angiotensin system - Mus musculus (mouse)
UniProt: P15946
Entrez ID: 16613
|
Does Knockout of Pspn in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Pspn
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pspn (persephin)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Mice lacking a functional copy of this gene exhibit hypersensitivity to cerebral ischemia. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: branching involved in ureteric bud morphogenesis, glial cell-derived neurotrophic factor receptor signaling pathway, peripheral nervous system development, system development; MF: glial cell-derived neurotrophic factor receptor binding, growth factor activity, receptor tyrosine kinase binding, signaling receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: A1L3Q1
Entrez ID: 19197
|
Does Knockout of 9330159F19Rik in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
9330159F19Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 9330159F19Rik (RIKEN cDNA 9330159F19 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A1L1SS16, D3Z623
Entrez ID: 212448
|
Does Knockout of Cercam in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Cercam
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cercam (cerebral endothelial cell adhesion molecule)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion; MF: identical protein binding, procollagen galactosyltransferase activity; CC: cellular_component, endoplasmic reticulum, endoplasmic reticulum lumen
Pathways:
UniProt: A3KGW5
Entrez ID: 99151
|
Does Knockout of Gapdh in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Gapdh
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gapdh (glyceraldehyde-3-phosphate dehydrogenase)
Type: protein-coding
Summary: This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, apoptotic process, canonical glycolysis, cellular response to type II interferon, defense response to fungus, gluconeogenesis, glucose metabolic process, glyceraldehyde-3-phosphate biosynthetic process, glycolytic process, immune system process, innate immune response, killing by host of symbiont cells, killing of cells of another organism, microtubule cytoskeleton organization, negative regulation of translation, neuron apoptotic process, peptidyl-cysteine S-trans-nitrosylation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cytokine production, positive regulation of type I interferon production, protein stabilization, regulation of translation; MF: NAD binding, NADP binding, aspartic-type endopeptidase inhibitor activity, disordered domain specific binding, enzyme binding, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, identical protein binding, microtubule binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, peptidyl-cysteine S-nitrosylase activity, protein binding, transferase activity; CC: GAIT complex, cytoplasm, cytoskeleton, cytosol, glutamatergic synapse, late endosome lumen, lipid droplet, microtubule cytoskeleton, mitochondrion, myelin sheath, nuclear membrane, nucleus, plasma membrane, postsynaptic density, intracellular component, ribonucleoprotein complex
Pathways: Alzheimer disease - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Gluconeogenesis, Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Salmonella infection - Mus musculus (mouse), gluconeogenesis I, glycolysis I, glycolysis III
UniProt: P16858
Entrez ID: 14433
|
Does Knockout of Pcdh1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Pcdh1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pcdh1 (protocadherin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, protein binding; CC: cell junction, cell-cell junction, membrane, nucleolus, nucleoplasm, plasma membrane
Pathways:
UniProt: A0A0A6YX79, Q8CFX3, A0A0A6YY88, F7BJK1, E0CXD4
Entrez ID: 75599
|
Does Knockout of Clstn2 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Clstn2
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Clstn2 (calsyntenin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: associative learning, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, inhibitory synapse assembly, positive regulation of synapse assembly, positive regulation of synaptic transmission; CC: Golgi apparatus, Golgi membrane, cell projection, cell surface, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, synapse
Pathways:
UniProt: Q9ER65
Entrez ID: 64085
|
Does Knockout of Scaf11 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Scaf11
|
cell cycle progression
|
breast epithelium
|
Gene: Scaf11 (SR-related CTD-associated factor 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, spliceosomal complex assembly; MF: metal ion binding, zinc ion binding; CC: nuclear body, nucleolus, nucleoplasm
Pathways:
UniProt: E9PZM7, Q6ZPE9, A0A2I3BQX1, A0A2I3BQU5, A0A2I3BRQ7, A0A2I3BQ68
Entrez ID: 72193
|
Does Knockout of Tlk2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Tlk2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Tlk2 (tousled-like kinase 2 (Arabidopsis))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cell differentiation, cellular response to gamma radiation, chromatin organization, chromosome segregation, intracellular signal transduction, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, nucleus localization, peptidyl-serine phosphorylation, protein phosphorylation, regulation of chromatin organization, spermatogenesis; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, transmembrane transporter binding; CC: cytoplasm, cytoskeleton, intermediate filament, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: O55047
Entrez ID: 24086
|
Does Knockout of Adsl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Adsl
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Adsl (adenylosuccinate lyase)
Type: protein-coding
Summary: This gene encodes a protein that is involved in adenosine monophosphate (AMP) biosynthesis and maintaining AMP levels in the muscle. The encoded enzyme catalyzes the release of fumarate during AMP biosynthesis by cleaving the substrates succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide (AICA) ribotide, and adenylosuccinate to give adenylate. In humans, this gene is associated with adenylosuccinate deficiency, a rare autosomal disorder resulting in a spectrum of neurological symptoms. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, AMP biosynthetic process, AMP salvage, GMP biosynthetic process, aerobic respiration, purine nucleotide biosynthetic process, purine ribonucleotide biosynthetic process, response to hypoxia, response to muscle activity, response to nutrient, response to starvation; MF: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity, N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity, catalytic activity, identical protein binding, lyase activity; CC: cytosol, mitochondrion, protein-containing complex
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis, adenosine nucleotides <i>de novo</i> biosynthesis, inosine-5,-phosphate biosynthesis II
UniProt: P54822
Entrez ID: 11564
|
Does Knockout of Mrps18b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Mrps18b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrps18b (mitochondrial ribosomal protein S18B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: cell junction, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q99N84
Entrez ID: 66973
|
Does Knockout of Chaf1b in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Chaf1b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Chaf1b (chromatin assembly factor 1, subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin assembly, chromatin organization, nucleosome assembly; CC: CAF-1 complex, chromatin, cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q9D0N7
Entrez ID: 110749
|
Does Knockout of Tgfbrap1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Tgfbrap1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tgfbrap1 (transforming growth factor, beta receptor associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, endosomal vesicle fusion, endosome to lysosome transport, intracellular protein transport, protein transport, regulation of DNA-templated transcription, signal transduction, vesicle-mediated transport; MF: SMAD binding, transforming growth factor beta receptor binding; CC: CORVET complex, cytoplasm, early endosome, endomembrane system, endosome, membrane
Pathways:
UniProt: Q3UR70
Entrez ID: 73122
|
Does Knockout of Sdhb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Sdhb
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Sdhb (succinate dehydrogenase complex, subunit B, iron sulfur (Ip))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, respiratory electron transport chain, succinate metabolic process, tricarboxylic acid cycle; MF: 2 iron, 2 sulfur cluster binding, 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, electron transfer activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, succinate dehydrogenase (quinone) activity, ubiquinone binding; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleoplasm, plasma membrane, respiratory chain complex II (succinate dehydrogenase)
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II, aerobic respiration -- electron donors reaction list
UniProt: Q9CQA3
Entrez ID: 67680
|
Does Knockout of Dsn1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Dsn1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dsn1 (DSN1 homolog, MIS12 kinetochore complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, skeletal muscle satellite cell proliferation; CC: MIS12/MIND type complex, chromosome, chromosome, centromeric region, cytosol, fibrillar center, kinetochore, nuclear body, nucleolus, nucleoplasm, nucleus, outer kinetochore, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, Immune System, Innate Immune System, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Neutrophil degranulation, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CYC5
Entrez ID: 66934
|
Does Knockout of Sncaip in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Sncaip
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sncaip (synuclein, alpha interacting protein (synphilin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dopamine metabolic process, regulation of inclusion body assembly, regulation of neurotransmitter secretion; MF: identical protein binding, ubiquitin protein ligase binding; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, nucleoplasm
Pathways: Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse)
UniProt: Q99ME3
Entrez ID: 67847
|
Does Knockout of Kcnk9 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Kcnk9
|
cell cycle progression
|
breast epithelium
|
Gene: Kcnk9 (potassium channel, subfamily K, member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to acidic pH, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of aldosterone secretion, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of action potential firing rate, regulation of resting membrane potential, sodium ion transmembrane transport, sodium ion transport, visual perception; MF: identical protein binding, metal ion binding, outward rectifier potassium channel activity, potassium channel activity, potassium ion leak channel activity, protein binding, protein heterodimerization activity, sodium channel activity, voltage-gated potassium channel activity; CC: cell projection, dendrite, membrane, mitochondrial inner membrane, mitochondrion, plasma membrane, synaptic vesicle
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Cardiac conduction, Muscle contraction, Neuronal System, Phase 4 - resting membrane potential, Potassium Channels, TWIK-releated acid-sensitive K+ channel (TASK), Tandem pore domain potassium channels
UniProt: Q3LS21
Entrez ID: 223604
|
Does Knockout of Pgrmc2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Pgrmc2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pgrmc2 (progesterone receptor membrane component 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, heme transport; MF: heme binding, heme transmembrane transporter activity, lipid binding, protein binding, steroid binding; CC: endomembrane system, endoplasmic reticulum, extracellular region, glutamatergic synapse, membrane, nuclear envelope, nucleus, synapse
Pathways: Cellular responses to stimuli, Cellular responses to stress, Heme signaling, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOD GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q80UU9
Entrez ID: 70804
|
Does Knockout of Cstf3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Cstf3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cstf3 (cleavage stimulation factor, 3' pre-RNA, subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, RNA processing, co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA processing; CC: mRNA cleavage stimulating factor complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q99LI7
Entrez ID: 228410
|
Does Knockout of Zswim1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Zswim1
|
phagocytosis
|
macrophage
|
Gene: Zswim1 (zinc finger SWIM-type containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q9CWV7
Entrez ID: 71971
|
Does Knockout of Polr3f in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Polr3f
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Polr3f (polymerase (RNA) III (DNA directed) polypeptide F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta production, transcription by RNA polymerase III; MF: 4 iron, 4 sulfur cluster binding, double-stranded DNA binding, iron-sulfur cluster binding, metal ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, cytoplasm, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: Q921X6
Entrez ID: 70408
|
Does Knockout of Cdh24 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Cdh24
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cdh24 (cadherin-like 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adherens junction organization, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, homophilic cell adhesion via plasma membrane adhesion molecules; MF: alpha-catenin binding, beta-catenin binding, cadherin binding, calcium ion binding, delta-catenin binding, metal ion binding; CC: adherens junction, catenin complex, cell-cell junction, membrane, plasma membrane
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization
UniProt: Q6PFX6
Entrez ID: 239096
|
Does Knockout of Ciapin1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Ciapin1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ciapin1 (cytokine induced apoptosis inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, hemopoiesis, iron-sulfur cluster assembly, negative regulation of apoptotic process; MF: 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, electron transfer activity, iron ion binding, iron-sulfur cluster binding, metal ion binding, protein binding; CC: cytoplasm, mitochondrial intermembrane space, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8WTY4
Entrez ID: 109006
|
Does Knockout of Emc4 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Emc4
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Emc4 (ER membrane protein complex subunit 4)
Type: protein-coding
Summary: Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Is expressed in lung. Orthologous to human EMC4 (ER membrane protein complex subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, protein insertion into ER membrane by stop-transfer membrane-anchor sequence, tail-anchored membrane protein insertion into ER membrane; MF: membrane insertase activity; CC: EMC complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9CZX9
Entrez ID: 68032
|
Does Knockout of Aasdhppt in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Aasdhppt
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Aasdhppt (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 10-formyltetrahydrofolate catabolic process, lysine biosynthetic process via aminoadipic acid, protein maturation; MF: holo-[acyl-carrier-protein] synthase activity, magnesium ion binding, metal ion binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Vitamin B5 (pantothenate) metabolism
UniProt: Q9CQF6
Entrez ID: 67618
|
Does Knockout of Sgk1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Sgk1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Sgk1 (serum/glucocorticoid regulated kinase 1)
Type: protein-coding
Summary: This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: DNA damage response, apoptotic process, cellular response to aldosterone, cellular response to insulin stimulus, intracellular signal transduction, intracellular sodium ion homeostasis, long-term memory, microtubule depolymerization, negative regulation of apoptotic process, negative regulation of microtubule polymerization, neuron projection morphogenesis, positive regulation of cell growth, positive regulation of dendrite morphogenesis, positive regulation of sodium ion transport, regulation of protein localization, sodium ion transport, visual learning; MF: 3-phosphoinositide-dependent protein kinase binding, ATP binding, kinase activity, nucleotide binding, potassium channel regulator activity, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, tau protein binding, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion, nuclear speck, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, Ion channel transport, NGF-stimulated transcription, Nuclear Events (kinase and transcription factor activation), PI3K-Akt signaling pathway - Mus musculus (mouse), PIP3 activates AKT signaling, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Stimuli-sensing channels, Transcriptional Regulation by TP53, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9WVC6
Entrez ID: 20393
|
Does Knockout of Adgrg2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Adgrg2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Adgrg2 (adhesion G protein-coupled receptor G2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, signal transduction, spermatid development; MF: G protein-coupled receptor activity, transmembrane signaling receptor activity; CC: apical plasma membrane, cytosol, membrane, plasma membrane
Pathways:
UniProt: Q8CJ12
Entrez ID: 237175
|
Does Knockout of Mrgprb2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Mrgprb2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mrgprb2 (MAS-related GPR, member B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, mast cell activation, mast cell degranulation, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of cytokinesis, positive regulation of neutrophil migration, response to pain, signal transduction; MF: G protein-coupled receptor activity, mast cell secretagogue receptor activity, neuropeptide binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q3KNA1
Entrez ID: 243979
|
Does Knockout of Adcy1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Adcy1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Adcy1 (adenylate cyclase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenylate cyclase-activating G protein-coupled receptor signaling pathway, axonogenesis, cAMP biosynthetic process, cellular response to calcium ion, cellular response to forskolin, cyclic nucleotide biosynthetic process, intracellular signal transduction, long-term memory, modulation of chemical synaptic transmission, neuroinflammatory response, positive regulation of CREB transcription factor activity, positive regulation of long-term synaptic potentiation, presynaptic modulation of chemical synaptic transmission, regulation of circadian rhythm, rhythmic process; MF: ATP binding, adenylate cyclase activity, calcium- and calmodulin-responsive adenylate cyclase activity, calmodulin binding, lyase activity, metal ion binding, nucleotide binding, phosphorus-oxygen lyase activity; CC: Schaffer collateral - CA1 synapse, axon hillock, cytoplasm, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane, membrane raft, nucleus, plasma membrane, postsynaptic density, postsynaptic density membrane, presynapse
Pathways: Activation of GABAB receptors, Adenylate cyclase activating pathway, Adenylate cyclase inhibitory pathway, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Bile secretion - Mus musculus (mouse), Ca-dependent events, CaM pathway, Calcium signaling pathway - Mus musculus (mouse), Calmodulin induced events, Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), DAG and IP3 signaling, Dilated cardiomyopathy - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), G alpha (i) signalling events, G alpha (z) signalling events, G-protein mediated events, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Mus musculus (mouse), GPCR downstream signalling, Gap junction - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hedgehog 'off' state, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Intracellular signaling by second messengers, Long-term potentiation - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Oocyte meiosis - Mus musculus (mouse), Opioid Signalling, Ovarian steroidogenesis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PKA activation, PKA-mediated phosphorylation of CREB, PLC beta mediated events, Pancreatic secretion - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Signaling by Hedgehog, Thermogenesis - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Transmission across Chemical Synapses, Vascular smooth muscle contraction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), cyclic AMP biosynthesis
UniProt: O88444
Entrez ID: 432530
|
Does Knockout of Syt2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Syt2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Syt2 (synaptotagmin II)
Type: protein-coding
Summary: This gene encodes a member of the synaptotagmin protein family. Synaptotagmin proteins are involved in membrane trafficking and are characterized by an N-terminal transmembrane region as well as tandem calcium binding domains. The encoded protein is able to bind inositol polyphosphate and is thought to be involved in synaptic function and neurotransmitter release. [provided by RefSeq, Sep 2017].
Gene Ontology: BP: calcium-dependent activation of synaptic vesicle fusion, cell differentiation, positive regulation of dendrite extension, regulation of calcium ion-dependent exocytosis, regulation of synaptic vesicle exocytosis, vesicle-mediated transport; MF: SNARE binding, calcium ion binding, calcium ion sensor activity, calcium-dependent phospholipid binding, inositol 1,3,4,5 tetrakisphosphate binding, metal ion binding, phosphatidylserine binding, protein binding, syntaxin binding; CC: axon, chromaffin granule membrane, cytoplasm, cytoplasmic vesicle, dense core granule, exocytic vesicle, membrane, neuromuscular junction, plasma membrane, synapse, synaptic vesicle membrane
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: P46097
Entrez ID: 20980
|
Does Knockout of Igll1 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Igll1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Igll1 (immunoglobulin lambda-like polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: antigen binding, protein binding; CC: IgG immunoglobulin complex, endoplasmic reticulum, extracellular region
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Binding and Uptake of Ligands by Scavenger Receptors, CD22 mediated BCR regulation, Cell surface interactions at the vascular wall, Classical antibody-mediated complement activation, Complement cascade, Creation of C4 and C2 activators, FCERI mediated Ca+2 mobilization, FCERI mediated MAPK activation, FCERI mediated NF-kB activation, FCGR activation, Fc epsilon receptor (FCERI) signaling, Fcgamma receptor (FCGR) dependent phagocytosis, Hemostasis, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Initial triggering of complement, Innate Immune System, Primary immunodeficiency - Mus musculus (mouse), Regulation of Complement cascade, Regulation of actin dynamics for phagocytic cup formation, Role of LAT2/NTAL/LAB on calcium mobilization, Role of phospholipids in phagocytosis, Scavenging of heme from plasma, Signaling by the B Cell Receptor (BCR), Vesicle-mediated transport
UniProt: P20764
Entrez ID: 16136
|
Does Knockout of Csf3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Csf3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Csf3 (colony stimulating factor 3 (granulocyte))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to cytokine stimulus, granulocyte colony-stimulating factor signaling pathway, granulocyte differentiation, immune response, positive regulation of actin filament polymerization, positive regulation of cell population proliferation, positive regulation of myeloid cell differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of transcription by RNA polymerase II, regulation of actin filament organization; MF: cytokine activity, enzyme binding, granulocyte colony-stimulating factor receptor binding, growth factor activity, signaling receptor binding; CC: endocytic vesicle lumen, extracellular region, extracellular space
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inactivation of CSF3 (G-CSF) signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Malaria - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Signaling by CSF3 (G-CSF)
UniProt: P09920
Entrez ID: 12985
|
Does Knockout of Fzr1 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,530
|
Knockout
|
Fzr1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Fzr1 (fizzy and cell division cycle 20 related 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA synthesis involved in mitotic DNA replication, anaphase-promoting complex-dependent catabolic process, cell division, lens fiber cell differentiation, mitotic G2 DNA damage checkpoint signaling, negative regulation of cellular senescence, positive regulation of anaphase-promoting complex-dependent catabolic process, positive regulation of cell population proliferation, positive regulation of ubiquitin protein ligase activity, protein ubiquitination, proteolysis involved in protein catabolic process, regulation of meiotic nuclear division, thymidine biosynthetic process; MF: anaphase-promoting complex binding, protein binding, ubiquitin ligase activator activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activator activity; CC: anaphase-promoting complex, nuclear membrane, nucleoplasm, nucleus
Pathways: APC/C-mediated degradation of cell cycle proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, DNA Replication, DNA Replication Pre-Initiation, G2/M Transition, Immune System, Mitotic G2-G2/M phases, Phosphorylation of Emi1, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, SCF-beta-TrCP mediated degradation of Emi1, Senescence-Associated Secretory Phenotype (SASP), Switching of origins to a post-replicative state, Synthesis of DNA, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9R1K5
Entrez ID: 56371
|
Does Knockout of Ppp1r7 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ppp1r7
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ppp1r7 (protein phosphatase 1, regulatory subunit 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein binding, protein phosphatase regulator activity; CC: chromosome, nucleus
Pathways:
UniProt: Q3UM45
Entrez ID: 66385
|
Does Knockout of Vmn1r237 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Vmn1r237
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vmn1r237 (vomeronasal 1 receptor 237)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R296
Entrez ID: 171234
|
Does Knockout of Rab29 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Rab29
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rab29 (RAB29, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, T cell activation, cell differentiation, cellular detoxification, cilium assembly, host-mediated perturbation of viral process, intracellular protein transport, melanosome organization, mitochondrion organization, negative regulation of neuron projection development, positive regulation of T cell receptor signaling pathway, positive regulation of intracellular protein transport, positive regulation of receptor recycling, protein localization to ciliary membrane, protein localization to membrane, protein transport, regulation of retrograde transport, endosome to Golgi, response to bacterium, retrograde transport, endosome to Golgi, synapse assembly, vesicle-mediated transport; MF: G protein activity, GDP binding, GTP binding, GTPase activity, dynein complex binding, kinesin binding, nucleotide binding, protein binding, small GTPase binding; CC: Golgi apparatus, Golgi membrane, cis-Golgi network, cytoplasm, cytoskeleton, cytosol, early endosome, endomembrane system, intracellular vesicle, melanosome, membrane, mitochondrion, nuclear membrane, nucleoplasm, perinuclear region of cytoplasm, plasma membrane, recycling endosome, trans-Golgi network, vacuole, vesicle
Pathways:
UniProt: M0QW55, E9QLQ7
Entrez ID: 226422
|
Does Knockout of Nelfa in Microglial Cell Line causally result in protein/peptide distribution?
| 1
| 1,585
|
Knockout
|
Nelfa
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Nelfa (negative elongation factor complex member A, Whsc2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription elongation by RNA polymerase II, positive regulation of transcription by RNA polymerase II; MF: chromatin binding, molecular adaptor activity, protein binding; CC: NELF complex, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q8BG30
Entrez ID: 24116
|
Does Knockout of Rrp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Rrp1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rrp1 (ribosomal RNA processing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: chromosome, nucleolus, nucleus, preribosome, small subunit precursor
Pathways:
UniProt: P56183
Entrez ID: 18114
|
Does Knockout of Pop1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Pop1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Pop1 (processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA 5'-leader removal, tRNA decay, tRNA processing; MF: ribonuclease P RNA binding, ribonuclease P activity; CC: multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonuclease MRP complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9D4G5, Q8K205
Entrez ID: 67724
|
Does Knockout of Abt1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Abt1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Abt1 (activator of basal transcription 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, small-subunit processome assembly, spinal cord motor neuron differentiation; MF: DNA binding, RNA binding, nucleic acid binding; CC: nucleolus, nucleus, transcription regulator complex
Pathways:
UniProt: Q9QYL7
Entrez ID: 30946
|
Does Knockout of Cks1brt in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Cks1brt
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Cks1brt (CDC28 protein kinase 1b, retrogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, fibroblast proliferation, mitotic cell cycle phase transition, regulation of mitotic cell cycle; MF: cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase regulator activity, histone binding, protein kinase binding, ubiquitin binding; CC: SCF ubiquitin ligase complex, cyclin-dependent protein kinase holoenzyme complex
Pathways: Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse)
UniProt: Q3UNC9
Entrez ID: 624855
|
Does Knockout of Nyx in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Nyx
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nyx (nyctalopin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: visual perception; MF: protein binding, signaling receptor activity; CC: dendrite, extracellular matrix, extracellular region, postsynapse
Pathways:
UniProt: P83503
Entrez ID: 236690
|
Does Knockout of Nmnat3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Nmnat3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nmnat3 (nicotinamide nucleotide adenylyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NAD+ biosynthetic process, NAD+ biosynthetic process via the salvage pathway, nicotinamide metabolic process, nucleotide biosynthetic process, pyridine nucleotide biosynthetic process, response to tumor necrosis factor, response to wounding; MF: ATP binding, adenylyltransferase activity, catalytic activity, nicotinamide-nucleotide adenylyltransferase activity, nicotinate-nucleotide adenylyltransferase activity, nucleotide binding, nucleotidyltransferase activity, transferase activity; CC: axon, mitochondrial matrix, mitochondrion, neuronal cell body
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, NAD biosynthesis III, NAD salvage pathway II, NAD salvage pathway III, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Nicotinate metabolism
UniProt: Q99JR6
Entrez ID: 74080
|
Does Knockout of Osbpl11 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 1
| 1,522
|
Knockout
|
Osbpl11
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Osbpl11 (oxysterol binding protein-like 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fat cell differentiation, lipid transport, triglyceride homeostasis; MF: lipid binding, sterol binding; CC: Golgi apparatus, cytosol, endosome, late endosome membrane, membrane, nucleoplasm
Pathways:
UniProt: A0A338P6F2, G5E8A0
Entrez ID: 106326
|
Does Knockout of Tbx18 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Tbx18
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tbx18 (T-box18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure formation involved in morphogenesis, anterior/posterior axis specification, cell differentiation, cell fate specification, cochlea morphogenesis, morphogenesis of embryonic epithelium, negative regulation of canonical Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, neural plate anterior/posterior regionalization, positive regulation of DNA-templated transcription, positive regulation of cell-cell adhesion, positive regulation of epithelial cell proliferation, positive regulation of mesenchymal cell proliferation, positive regulation of mesenchymal cell proliferation involved in ureter development, positive regulation of myoblast proliferation, positive regulation of stem cell proliferation, regulation of DNA-templated transcription, regulation of SA node cell action potential, regulation of transcription by RNA polymerase II, sensory perception of sound, sinoatrial node cell development, sinoatrial node cell fate commitment, sinoatrial node development, smooth muscle cell differentiation, somitogenesis, stem cell differentiation, ureter development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, protein homodimerization activity, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription repressor complex, chromatin, nucleoplasm, nucleus
Pathways:
UniProt: Q9EPZ6
Entrez ID: 76365
|
Does Knockout of Ubtd2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Ubtd2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ubtd2 (ubiquitin domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6PGH0
Entrez ID: 327900
|
Does Knockout of Spdl1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Spdl1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Spdl1 (spindle apparatus coiled-coil protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cell migration, establishment of mitotic spindle orientation, mitotic metaphase chromosome alignment, mitotic spindle assembly checkpoint signaling, protein localization to kinetochore; MF: enzyme binding, kinetochore binding; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, kinetochore, nucleus, outer kinetochore, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q923A2
Entrez ID: 70385
|
Does Knockout of Rpl13 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Rpl13
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rpl13 (ribosomal protein L13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, bone development, cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, nucleolus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P47963
Entrez ID: 270106
|
Does Knockout of Mtbp in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Mtbp
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Mtbp (Mdm2, transformed 3T3 cell double minute p53 binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell population proliferation, negative regulation of mitotic nuclear division, protein localization to kinetochore, regulation of cell cycle, regulation of protein ubiquitination, traversing start control point of mitotic cell cycle; CC: chromatin, kinetochore
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Degradation of CDH1, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q8BJS8
Entrez ID: 105837
|
Does Knockout of Rassf8 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Rassf8
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Rassf8 (Ras association (RalGDS/AF-6) domain family (N-terminal) member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8CJ96
Entrez ID: 71323
|
Does Knockout of Fbl in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Fbl
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Fbl (fibrillarin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: box C/D sno(s)RNA 3'-end processing, chromatin remodeling, methylation, rRNA methylation, rRNA processing, ribosomal small subunit biogenesis, sno(s)RNA metabolic process, snoRNA localization; MF: ATPase binding, RNA binding, TFIID-class transcription factor complex binding, U6 snRNA 2'-O-ribose methyltransferase activity, histone H2AQ104 methyltransferase activity, methyltransferase activity, rRNA methyltransferase activity, transferase activity; CC: Cajal body, box C/D methylation guide snoRNP complex, chromosome, dense fibrillar component, fibrillar center, granular component, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P35550
Entrez ID: 14113
|
Does Knockout of Ctcf in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Ctcf
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Ctcf (CCCTC-binding factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cardiac muscle cell development, cardiac muscle cell differentiation, chromatin looping, chromatin organization, chromosome segregation, epigenetic regulation of gene expression, gene expression, genomic imprinting, heart development, in utero embryonic development, mitochondrion organization, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of miRNA transcription, positive regulation of transcription by RNA polymerase II, protein localization to chromosome, centromeric region, random inactivation of X chromosome, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, chromatin insulator sequence binding, chromatin loop anchoring activity, cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coregulator binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, dense fibrillar component, granular component, male germ cell nucleus, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q61164
Entrez ID: 13018
|
Does Knockout of Pdxk in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Pdxk
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pdxk (pyridoxal (pyridoxine, vitamin B6) kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: pyridoxal 5'-phosphate salvage, pyridoxal metabolic process, pyridoxal phosphate metabolic process, pyridoxamine metabolic process, pyridoxine metabolic process; MF: ATP binding, kinase activity, lithium ion binding, magnesium ion binding, metal ion binding, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, potassium ion binding, protein homodimerization activity, pyridoxal binding, pyridoxal kinase activity, pyridoxal phosphate binding, sodium ion binding, transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Immune System, Innate Immune System, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Neutrophil degranulation, Vitamin B6 activation to pyridoxal phosphate, Vitamin B6 metabolism - Mus musculus (mouse), pyridoxal 5,-phosphate salvage pathway
UniProt: Q8K183
Entrez ID: 216134
|
Does Knockout of Abraxas1 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Abraxas1
|
response to virus
|
Microglial Cell Line
|
Gene: Abraxas1 (BRCA1 A complex subunit)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; nuclear chromosome segregation; and positive regulation of DNA repair. Predicted to be located in nuclear body. Predicted to be part of BRCA1-A complex. Predicted to be active in nucleus. Orthologous to human ABRAXAS1 (abraxas 1, BRCA1 A complex subunit). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, attachment of spindle microtubules to kinetochore, chromatin organization, double-strand break repair, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, mitotic spindle assembly, positive regulation of DNA repair, regulation of DNA repair, response to ionizing radiation; MF: microtubule binding, polyubiquitin modification-dependent protein binding; CC: BRCA1-A complex, nuclear body, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, G2/M DNA damage checkpoint, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Processing of DNA double-strand break ends, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q8BPZ8
Entrez ID: 70681
|
Does Knockout of Ppa1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Ppa1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ppa1 (pyrophosphatase (inorganic) 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phosphate-containing compound metabolic process; MF: hydrolase activity, inorganic diphosphate phosphatase activity, magnesium ion binding, metal ion binding, pyrophosphatase activity
Pathways: Cytosolic tRNA aminoacylation, Metabolism, Metabolism of proteins, Oxidative phosphorylation - Mus musculus (mouse), Pyrophosphate hydrolysis, Translation, tRNA Aminoacylation
UniProt: Q9D819
Entrez ID: 67895
|
Does Knockout of Pon3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Pon3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pon3 (paraoxonase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carboxylic acid catabolic process, coumarin catabolic process, establishment of localization in cell, lactone catabolic process, negative regulation of superoxide anion generation, phenylacetate catabolic process, regulation of cellular response to drug, renal sodium ion transport, response to toxic substance; MF: acyl-L-homoserine-lactone lactonohydrolase activity, aryldialkylphosphatase activity, arylesterase activity, dihydrocoumarin hydrolase activity, hydrolase activity, metal ion binding, protein homodimerization activity; CC: extracellular region, extracellular space
Pathways: Arachidonate metabolism, Atorvastatin ADME, Drug ADME, Fatty acid metabolism, Metabolism, Metabolism of lipids, Synthesis of 5-eicosatetraenoic acids
UniProt: Q62087
Entrez ID: 269823
|
Does Knockout of Mccc2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Mccc2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mccc2 (methylcrotonoyl-Coenzyme A carboxylase 2 (beta))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-leucine catabolic process, coenzyme A metabolic process; MF: ATP binding, ligase activity, methylcrotonoyl-CoA carboxylase activity, nucleotide binding; CC: methylcrotonoyl-CoA carboxylase complex, mitochondrial matrix, mitochondrion
Pathways: Biotin transport and metabolism, Branched-chain amino acid catabolism, Leucine Catabolism, Metabolism, Metabolism of amino acids and derivatives, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Valine, leucine and isoleucine degradation - Mus musculus (mouse), leucine degradation I
UniProt: Q3ULD5
Entrez ID: 78038
|
Does Knockout of Npat in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Npat
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Npat (nuclear protein in the AT region)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell cycle G1/S phase transition, in utero embryonic development, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II; MF: transcription coactivator activity, transcription coregulator activity, transcription corepressor activity; CC: Cajal body, Gemini of Cajal bodies, cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q8BMA5
Entrez ID: 244879
|
Does Knockout of Lipt2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,171
|
Knockout
|
Lipt2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Lipt2 (lipoyl(octanoyl) transferase 2 (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of oxygen metabolic process, protein lipoylation; MF: acyltransferase activity, ligase activity, lipoyl(octanoyl) transferase activity, protein binding, transferase activity; CC: mitochondrion
Pathways: Lipoic acid metabolism - Mus musculus (mouse), Metabolism of proteins, Post-translational protein modification, Protein lipoylation
UniProt: Q9D009
Entrez ID: 67164
|
Does Knockout of 4930544D05Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
4930544D05Rik
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: 4930544D05Rik (RIKEN cDNA 4930544D05 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: J3QJW4, J3QK56, J3KMM3
Entrez ID: 668433
|
Does Knockout of Cers3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Cers3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cers3 (ceramide synthase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, cornification, epidermis development, keratinocyte differentiation, lipid metabolic process, sphingolipid biosynthetic process, sphingolipid metabolic process; MF: DNA binding, sphingosine N-acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), ceramide biosynthesis
UniProt: Q1A3B0
Entrez ID: 545975
|
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